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Institute
- Institut für Biochemie und Biologie (85)
- Hasso-Plattner-Institut für Digital Engineering GmbH (83)
- Institut für Physik und Astronomie (83)
- Institut für Geowissenschaften (61)
- Institut für Mathematik (46)
- Department Psychologie (44)
- Department Sport- und Gesundheitswissenschaften (44)
- Hasso-Plattner-Institut für Digital Engineering gGmbH (31)
- Institut für Chemie (30)
- Institut für Ernährungswissenschaft (30)
New Public Governance (NPG) as a paradigm for collaborative forms of public service delivery and Blockchain governance are trending topics for researchers and practitioners alike. Thus far, each topic has, on the whole, been discussed separately. This paper presents the preliminary results of ongoing research which aims to shed light on the more concrete benefits of Blockchain for the purpose of NPG. For the first time, a conceptual analysis is conducted on process level to spot benefits and limitations of Blockchain-based governance. Per process element, Blockchain key characteristics are mapped to functional aspects of NPG from a governance perspective. The preliminary results show that Blockchain offers valuable support for governments seeking methods to effectively coordinate co-producing networks. However, the extent of benefits of Blockchain varies across the process elements. It becomes evident that there is a need for off-chain processes. It is, therefore, argued in favour of intensifying research on off-chain governance processes to better understand the implications for and influences on on-chain governance.
Tailed bacteriophages specific for Gram‐negative bacteria encounter lipopolysaccharide (LPS) during the first infection steps. Yet, it is not well understood how biochemistry of these initial interactions relates to subsequent events that orchestrate phage adsorption and tail rearrangements to initiate cell entry. For many phages, long O‐antigen chains found on the LPS of smooth bacterial strains serve as essential receptor recognized by their tailspike proteins (TSP). Many TSP are depolymerases and O‐antigen cleavage was described as necessary step for subsequent orientation towards a secondary receptor. However, O‐antigen specific host attachment must not always come along with O‐antigen degradation. In this issue of Molecular Microbiology Prokhorov et al. report that coliphage G7C carries a TSP that deacetylates O‐antigen but does not degrade it, whereas rough strains or strains lacking O‐antigen acetylation remain unaffected. Bacteriophage G7C specifically functionalizes its tail by attaching the deacetylase TSP directly to a second TSP that is nonfunctional on the host's O‐antigen. This challenges the view that bacteriophages use their TSP only to clear their way to a secondary receptor. Rather, O‐antigen specific phages may employ enzymatically active TSP as a tool for irreversible LPS membrane binding to initiate subsequent infection steps.
1. Der Staat ist nach dem Krankenhausfinanzierungsgesetz und dem Grundgesetz zur funktionsgerechten Finanzierung der in den Krankenhausplan eines Landes aufgenommenen (Plan-)Krankenhäuser verpflichtet. Um die Versorgung der Bevölkerung mit Krankenhausbehandlung sicherzustellen, müssen die Länder sämtliche bei wirtschaftlicher Betriebsführung notwendigen Investitionskosten der Plankrankenhäuser decken (§ 1 Abs. 1, § 4 Nr. 1, § 9 Abs. 5 KHG, Art. 12 Abs. 1 GG). Es gilt das Kostendeckungsprinzip. Die Sozialleistungsträger müssen Krankenhäuser durch leistungsgerechte Erlöse aus den Pflegesätzen wirtschaftlich sichern (§ 1 Abs. 1, § 4 Nr. 2 KHG, Art. 12 Abs. 1 GG).
2. Die Vergütung der Krankenhäuser durch die Sozialleistungsträger ist unzureichend. Die Fallpauschalen des DRG-Systems bleiben hinter dem zur Betriebskostenfinanzierung erforderlichen Maß zurück, weil die anhaltenden Preissteigerungen in den Landesbasisfallwerten nicht ausreichend berücksichtigt sind.
3. Die Länder kommen ihrer gesetzlichen und verfassungsrechtlichen Verpflichtung zur Übernahme der notwendigen Investitionskosten der Plankrankenhäuser seit vielen Jahren ungenügend nach.
4. Vor allem Kommunen, aber auch Länder gewähren staatlichen Krankenhäusern Ausgleichsleistungen wie Jahresfehlbetragsdeckungen, Investitions- und Betriebskostenzuschüsse, Eigenkapitalerhöhungen, zinsvergünstigte Darlehen, kostenfreie Bürgschaften und Liquiditätshilfen (sog. Defizitausgleich). Eine weitere Form des selektiven Defizitausgleichs ist die Übernahme der Kosten von Entlastungstarifverträgen staatlicher Kliniken durch Länder. Freigemeinnützige und private Krankenhäuser erhalten bislang keinen solchen Defizitausgleich.
5. Der selektive Defizitausgleich eines Landes nur für staatliche Krankenhäuser verstößt gegen das gesetzliche (§ 1 Abs. 2 S. 1 und 2 KHG) und verfassungsrechtliche (Art. 12 Abs. 1 i.V.m. Art. 3 Abs. 1 GG) Gebot der Gleichbehandlung der Plankrankenhäuser (Prinzip der Trägervielfalt). Er ist des halb rechts- und verfassungswidrig.
6. Ein selektiver Defizitausgleich von Kommunen nur für eigene (kommunale) Krankenhäuser verstößt gegen das landesgesetzliche Prinzip der Trägervielfalt und das Gleichbehandlungsgebot des Art. 3 Abs. 1 GG und ist somit unzulässig.
7. Auf eigene Krankenhäuser beschränkte Ausgleichsleistungen von Kommunen oder Ländern sind eine unzulässige Beihilfe i.S.d. Art. 107 Abs. 1 AEUV und deshalb unvereinbar mit dem EU-Beihilferecht. Das gilt sowohl, wenn staatliche Krankenhäuser Ausgleichsleistungen für die Versorgung der Bevölkerung mit Krankenhausbehandlung (s. § 109 Abs. 1 S. 1 und 2, Abs. 4 S. 2 SGB V) erhalten, als auch, wenn der Ausgleich „Gegenleistung“ für eine hoheitlich auferlegte Betriebspflicht ist. Eine wirksame Durchsetzung des EU-Beihilferechts und effektiver Rechtsschutz für nicht begünstigte freigemeinnützige und private Krankenhäuser erfordern Transparenz und eine entsprechende Veröffentlichung der Betrauungsakte der Länder und Kommunen.
8. Ein Defizitausgleich für alle in den Krankenhausplan eines Landes aufgenommenen (Plan-)Krankenhäuser ist beihilferechtlich zulässig. Da sämtliche Plankrankenhäuser Dienstleistungen von allgemeinem wirtschaftlichen Interesse (DAWI) erbringen (gesetzliche Pflicht zur Versorgung der Bevölkerung mit Krankenhausbehandlung), müssen sie nach dem EU-Beihilferecht bei staatlichen Ausgleichsleistungen für die Erfüllung der Versorgungspflicht gleichbehandelt werden. Art. 107 Abs. 1 AEUV ist entsprochen, wenn entweder ein selektiver Defizitausgleich für staatliche Plankrankenhäuser unterbleibt bzw. aufgehoben und rückabgewickelt wird oder alle – staatlichen, freigemeinnützigen und privaten Plankrankenhäuser – gleichgefördert werden.
9. Diese nach dem EU-Beihilferecht bestehende Wahlmöglichkeit kann den Ländern nach nationalem Recht verschlossen sein. Ein Ausgleich der Länder für Investitionskosten ist prinzipiell erforderlich, um der gesetzlichen Verpflichtung aus § 1 Abs. 1, § 4 Nr. 1, § 9 Abs. 5 KHG nachzukommen und die notwendigen Investitionskosten der Plankrankenhäuser unter Beachtung betriebswirtschaftlicher Grundsätze zu decken. Freigemeinnützige und private Krankenhäuser haben Anspruch auf Ausgleichsleistungen zur Investitionskostendeckung bereits wegen des gesetzlichen Gebots funktionsgerechter Finanzierung (§ 8 Abs. 1 S. 1 KHG) und aus ihrem Grundrecht der Berufsfreiheit (Art. 12 Abs. 1 GG). Ihnen kann dieser Anspruch aber auch wegen des gesetzlichen und verfassungsrechtlichen Gebots der Gleichbehandlung zustehen. Gewähren die Länder staatlichen Plankrankenhäusern bei wirtschaftlicher Betriebsführung Ausgleichsleistungen, um ihrer Verpflichtung zur Übernahme notwendiger Investitionskosten nachzukommen, müssen sie freigemeinnützigen und privaten Plankrankenhäusern nach dem Gleichbehandlungsgebot einen entsprechenden Ausgleich zahlen (§ 8 Abs. 1 S. 1 i.V.m. § 1 Abs. 2 S. 1 und 2 KHG, Art. 12 Abs. 1 i.V.m. Art. 3 Abs. 1 GG). Einer nach nationalem Recht gebotenen, gleichen Förderung aller Plankrankenhäuser steht das EU-Beihilferecht nicht entgegen.
10. Die Kommunen sind dagegen nach nationalem Recht (über die Krankenhausumlage hinaus) nicht zur Krankenhausfinanzierung verpflichtet. Sie entscheiden gem. Art. 28 Abs. 2 S. 1 GG (Gemeinden) bzw. gem. Art. 28 Abs. 2 S. 2 GG i.V.m. Landeskrankenhausrecht (Gemeindeverbände) eigenverantwortlich, ob und in welchem Umfang sie Plankrankenhäuser unter Beachtung des Wirtschaftlichkeitsgebots finanziell unterstützen (Investitions- und Betriebskosten). Dementsprechend engt das nationale Recht die nach EU-Beihilferecht bestehende Wahlmöglichkeit für Kommunen nicht ein, selektive Ausgleichsleistungen für kommunale Krankenhäuser zu unterlassen bzw. aufzuheben und rückabzuwickeln oder sie so umzugestalten, dass freigemeinnützige und private Plankrankenhäuser die gleiche Förderung erhalten. Scheidet allerdings eine Rückzahlung der von Kommunen an ihre Krankenhäuser gezahlten Finanzmittel wegen tatsächlicher Unmöglichkeit aus, wird dem EU-Beihilferecht nur entsprochen, wenn die Kommunen freigemeinnützige und private Plankrankenhäuser gleichermaßen fördern.
11. Ohne eine Nachzahlung der in den letzten Jahren unterbliebenen Förderung durch die Sozialleistungsträger und die Länder ist die anstehende Krankenhausreform für die Krankenhäuser nicht zu bewältigen. Um die geplante Umstellung auf neue Versorgungslevel und Leistungsgruppen vornehmen und die hiermit verbundenen kostenintensiven Umstrukturierungsprozesse leisten zu können, muss die infolge unzureichender Krankenhausfinanzierung entstandene Unterfinanzierung der Krankenhäuser vor der Reform behoben werden. Die Forderungen nach „Vorschaltgesetzen“ sind daher berechtigt.
We investigate how the technology acceptance and learning experience of the digital education platform HPI Schul-Cloud (HPI School Cloud) for German secondary school teachers can be improved by proposing a user-centered research and development framework. We highlight the importance of developing digital learning technologies in a user-centered way to take differences in the requirements of educators and students into account. We suggest applying qualitative and quantitative methods to build a solid understanding of a learning platform's users, their needs, requirements, and their context of use. After concept development and idea generation of features and areas of opportunity based on the user research, we emphasize on the application of a multi-attribute utility analysis decision-making framework to prioritize ideas rationally, taking results of user research into account. Afterward, we recommend applying the principle build-learn-iterate to build prototypes in different resolutions while learning from user tests and improving the selected opportunities. Last but not least, we propose an approach for continuous short- and long-term user experience controlling and monitoring, extending existing web- and learning analytics metrics.
Editorial
(2019)
For a singularly perturbed parabolic - ODE system we construct the asymptotic expansion in the small parameter in the case, when the degenerate equation has a double root. Such systems, which are called partly dissipative reaction-diffusion systems, are used to model various natural processes, including the signal transmission along axons, solid combustion and the kinetics of some chemical reactions. It turns out that the algorithm of the construction of the boundary layer functions and the behavior of the solution in the boundary layers essentially differ from that ones in case of a simple root. The multizonal initial and boundary layers behaviour was stated.
We present a project combining lidar, photometer and particle counter data with a regularization software tool for a closure study of aerosol microphysical property retrieval. In a first step only lidar data are used to retrieve the particle size distribution (PSD). Secondly, photometer data are added, which results in a good consistency of the retrieved PSDs. Finally, those retrieved PSDs may be compared with the measured PSD from a particle counter. The data here were taken in Ny Alesund, Svalbard, as an example.
Learning how to prove
(2018)
We have developed an alternative approach to teaching computer science students how to prove. First, students are taught how to prove theorems with the Coq proof assistant. In a second, more difficult, step students will transfer their acquired skills to the area of textbook proofs. In this article we present a realisation of the second step. Proofs in Coq have a high degree of formality while textbook proofs have only a medium one. Therefore our key idea is to reduce the degree of formality from the level of Coq to textbook proofs in several small steps. For that purpose we introduce three proof styles between Coq and textbook proofs, called line by line comments, weakened line by line comments, and structure faithful proofs. While this article is mostly conceptional we also report on experiences with putting our approach into practise.
Adsorption of amino acids on the magnetite-(111)-surface: a force field study (vol 19, 851, 2013)
(2016)
Several overlapping crises which affected the EU during the past ten years have recently aggravated. Especially the progressing refugee crisis, the persisting financial crisis and geopolitical turmoil in the EU's neighbourhood contributed to the rise of anti-EU movements and diverse articulations of Euroscepticism. Although public opinion and mainstream political analysis have easily identified right-wing populism as one of the most important drivers, it is still doubtful if it can be equated with Euroscepticism without further ado. To date it is by no means clear how and where Euroscepticism exactly originates.
A distinguishing feature of Answer Set Programming is that all atoms belonging to a stable model must be founded. That is, an atom must not only be true but provably true. This can be made precise by means of the constructive logic of Here-and-There, whose equilibrium models correspond to stable models. One way of looking at foundedness is to regard Boolean truth values as ordered by letting true be greater than false. Then, each Boolean variable takes the smallest truth value that can be proven for it. This idea was generalized by Aziz to ordered domains and applied to constraint satisfaction problems. As before, the idea is that a, say integer, variable gets only assigned to the smallest integer that can be justified. In this paper, we present a logical reconstruction of Aziz’ idea in the setting of the logic of Here-and-There. More precisely, we start by defining the logic of Here-and-There with lower bound founded variables along with its equilibrium models and elaborate upon its formal properties. Finally, we compare our approach with related ones and sketch future work.
Reinhard Hujer
(2020)
Playful Classics
(2021)
Kim et al. recently measured the structure factor of deeply supercooled water droplets (Reports, 22 December 2017, p. 1589). We raise several concerns about their data analysis and interpretation. In our opinion, the reported data do not lead to clear conclusions about the origins of water’s anomalies.
Mobile operating systems, such as Google's Android, have become a fixed part of our daily lives and are entrusted with a plethora of private information. Congruously, their data protection mechanisms have been improved steadily over the last decade and, in particular, for Android, the research community has explored various enhancements and extensions to the access control model. However, the vast majority of those solutions has been concerned with controlling the access to data, but equally important is the question of how to control the flow of data once released. Ignoring control over the dissemination of data between applications or between components of the same app, opens the door for attacks, such as permission re-delegation or privacy-violating third-party libraries. Controlling information flows is a long-standing problem, and one of the most recent and practical-oriented approaches to information flow control is secure multi-execution.
In this paper, we present Ariel, the design and implementation of an IFC architecture for Android based on the secure multi-execution of apps. Ariel demonstrably extends Android's system with support for executing multiple instances of apps, and it is equipped with a policy lattice derived from the protection levels of Android's permissions as well as an I/O scheduler to achieve control over data flows between application instances. We demonstrate how secure multi-execution with Ariel can help to mitigate two prominent attacks on Android, permission re-delegations and malicious advertisement libraries.
Nitrogen transformations in flowpaths leading from soils to streams in Amazon forest and pasture
(2009)
The present work is part of a collaborative H2020 European funded research project called SENSKIN, that aims to improve Structural Health Monitoring (SHM) for transport infrastructure through the development of an innovative monitoring and management system for bridges based on a novel, inexpensive, skin-like sensor. The integrated SENSKIN technology will be implemented in the case of steel and concrete bridges, and tested, field-evaluated and benchmarked on actual bridge environment against a conventional health monitoring solution developed by Mistras Group Hellas. The main objective of the present work is to implement the autonomous, fully functional strain monitoring system based on commercially available off-the-shelf components, that will be used to accomplish direct comparison between the performance of the innovative SENSKIN sensors and the conventional strain sensors commonly used for structural monitoring of bridges. For this purpose, the mini Structural Monitoring System (mini SMS) of Physical Acoustics Corporation, a comprehensive data acquisition unit designed specifically for long-term unattended operation in outdoor environments, was selected. For the completion of the conventional system, appropriate foil-type strain sensors were selected, driven by special conditioners manufactured by Mistras Group. A comprehensive description of the strain monitoring system and its peripheral components is provided in this paper. For the evaluation of the integrated system’s performance and the effect of various parameters on the long-term behavior of sensors, several test steel pieces instrumented with different strain sensors configurations were prepared and tested in both laboratory and field ambient conditions. Furthermore, loading tests were performed aiming to validate the response of the system in monitoring the strains developed in steel beam elements subject to bending regimes. Representative results obtained from the above experimental tests have been included in this paper as well.
Since the Shallow Structure Hypothesis (SSH) was first put forward in 2006, it has inspired a growing body of research on grammatical processing in nonnative (L2) speakers. More than 10 years later, we think it is time for the SSH to be reconsidered in the light of new empirical findings and current theoretical assumptions about human language processing. The purpose of our critical commentary is twofold: to clarify some issues regarding the SSH and to sketch possible ways in which this hypothesis might be refined and improved to better account for L1 and L2 speakers’ performance patterns.
Business processes constantly generate, manipulate, and consume data that are managed by organizational databases. Despite being central to process modeling and execution, the link between processes and data is often handled by developers when the process is implemented, thus leaving the connection unexplored during the conceptual design. In this paper, we introduce, formalize, and evaluate a novel conceptual view that bridges the gap between process and data models, and show some kinds of interesting insights that can be derived from this novel proposal.
Planstadt Doberlug
(2020)
Various techniques are utilized by the seismological community, extractive industries, energy and geoengineering companies to identify earthquake nucleation processes in close proximity to engineering operation points. These operations may comprise fluid extraction or injections, artificial water reservoir impoundments, open pit and deep mining, deep geothermal power generations or carbon sequestration. In this letter to the editor, we outline several lines of investigation that we suggest to follow to address the discrimination problem between natural seismicity and seismic events induced or triggered by geoengineering activities. These suggestions have been developed by a group of experts during several meetings and workshops, and we feel that their publication as a summary report is helpful for the geoscientific community. Specific investigation procedures and discrimination approaches, on which our recommendations are based, are also published in this Special Issue (SI) of Journal of Seismology.
Pace-of-life syndromes
(2018)
This introduction to the topical collection on Pace-of-life syndromes: a framework for the adaptive integration of behaviour, physiology, and life history provides an overview of conceptual, theoretical, methodological, and empirical progress in research on pace-of-life syndromes (POLSs) over the last decade. The topical collection has two main goals. First, we briefly describe the history of POLS research and provide a refined definition of POLS that is applicable to various key levels of variation (genetic, individual, population, species). Second, we summarise the main lessons learned from current POLS research included in this topical collection. Based on an assessment of the current state of the theoretical foundations and the empirical support of the POLS hypothesis, we propose (i) conceptual refinements of theory, particularly with respect to the role of ecology in the evolution of (sexual dimorphism in) POLS, and (ii) methodological and statistical approaches to the study of POLS at all major levels of variation. This topical collection further holds (iii) key empirical examples demonstrating how POLS structures may be studied in wild populations of (non) human animals, and (iv) a modelling paper predicting POLS under various ecological conditions. Future POLS research will profit from the development of more explicit theoretical models and stringent empirical tests of model assumptions and predictions, increased focus on how ecology shapes (sex-specific) POLS structures at multiple hierarchical levels, and the usage of appropriate statistical tests and study designs. Significance statement As an introduction to the topical collection, we summarise current conceptual, theoretical, methodological and empirical progress in research on pace-of-life syndromes (POLSs), a framework for the adaptive integration of behaviour, physiology and life history at multiple hierarchical levels of variation (genetic, individual, population, species). Mixed empirical support of POLSs, particularly at the within-species level, calls for an evaluation and refinement of the hypothesis. We provide a refined definition of POLSs facilitating testable predictions. Future research on POLSs will profit from the development of more explicit theoretical models and stringent empirical tests of model assumptions and predictions, increased focus on how ecology shapes (sex-specific) POLSs structures at multiple hierarchical levels and the usage of appropriate statistical tests and study designs.
Stable covalently photo-cross-linked porous poly(ionic liquid) membrane with gradient pore size
(2018)
Porous polyelectrolyte membranes stable in a highly ionic environment are obtained by covalent crosslinking of an imidazolium-based poly(ionic liquid). The crosslinking reaction involves the UV light-induced thiol-ene (click) chemistry, and the phase separation, occurring during the crosslinking step, generates a fully interconnected porous structure in the membrane. The porosity is on the order of the micrometer scale and the membrane shows a gradient of pore size across the membrane cross-section. The membrane can separate polystyrene latex particles of different size and undergoes actuation in contact with acetone due to the asymmetric porous structure.
BIOMEX (BIOlogy and Mars EXperiment) is an ESA/Roscosmos space exposure experiment housed within the exposure facility EXPOSE-R2 outside the Zvezda module on the International Space Station (ISS). The design of the multiuser facility supports-among others-the BIOMEX investigations into the stability and level of degradation of space-exposed biosignatures such as pigments, secondary metabolites, and cell surfaces in contact with a terrestrial and Mars analog mineral environment. In parallel, analysis on the viability of the investigated organisms has provided relevant data for evaluation of the habitability of Mars, for the limits of life, and for the likelihood of an interplanetary transfer of life (theory of lithopanspermia). In this project, lichens, archaea, bacteria, cyanobacteria, snow/permafrost algae, meristematic black fungi, and bryophytes from alpine and polar habitats were embedded, grown, and cultured on a mixture of martian and lunar regolith analogs or other terrestrial minerals. The organisms and regolith analogs and terrestrial mineral mixtures were then exposed to space and to simulated Mars-like conditions by way of the EXPOSE-R2 facility. In this special issue, we present the first set of data obtained in reference to our investigation into the habitability of Mars and limits of life. This project was initiated and implemented by the BIOMEX group, an international and interdisciplinary consortium of 30 institutes in 12 countries on 3 continents. Preflight tests for sample selection, results from ground-based simulation experiments, and the space experiments themselves are presented and include a complete overview of the scientific processes required for this space experiment and postflight analysis. The presented BIOMEX concept could be scaled up to future exposure experiments on the Moon and will serve as a pretest in low Earth orbit.
Immune to COVID?
(2021)
Das Projekt beschäftigt sich mit der visuellen Wirkungsdimension von Lyrik und der Möglichkeit ihrer analytischen Beschreibung. Dafür werden die Anordnung von Versen und Wörtern, Auszeichnungen und andere typographische Strukturen von nicht experimentellen Gedichten seit Ende des 18. Jahrhunderts im Rahmen von Modellanalysen untersucht.
Communicative Reason Juergen Habermas, interviewed by Christoph Demmerling and Hans-Peter Krueger
(2016)
Jurgen Habermas explicates the concept of communicative reason. He explains the key assumptions of the philosophy of language and social theory associated with this concept. Also discussed is the category of life-world and the role of the body-mind difference for the consciousness of exclusivity in our access to subjective experience. as well as the role of emotions and perceptions in the context of a theory of communicative action. The question of the redemption of the various validity claims as they are associated with the performance of speech acts is related to processes of social learning and to the role of negative experiences. Finally the interview deals with the relationship between religion and reason and the importance of religion in modern, post-secular societies. Questions about the philosophical culture of our present times are discussed at the end of the conversation.
The problem of constructing and maintaining a tree topology in a distributed manner is a challenging task in WSNs. This is because the nodes have limited computational and memory resources and the network changes over time. We propose the Dynamic Gallager-Humblet-Spira (D-GHS) algorithm that builds and maintains a minimum spanning tree. To do so, we divide D-GHS into four phases, namely neighbor discovery, tree construction, data collection, and tree maintenance. In the neighbor discovery phase, the nodes collect information about their neighbors and the link quality. In the tree construction, D-GHS finds the minimum spanning tree by executing the Gallager-Humblet-Spira algorithm. In the data collection phase, the sink roots the minimum spanning tree at itself, and each node sends data packets. In the tree maintenance phase, the nodes repair the tree when communication failures occur. The emulation results show that D-GHS reduces the number of control messages and the energy consumption, at the cost of a slight increase in memory size and convergence time.
Vorwort
(2019)
3D point cloud technology facilitates the automated and highly detailed digital acquisition of real-world environments such as assets, sites, cities, and countries; the acquired 3D point clouds represent an essential category of geodata used in a variety of geoinformation applications and systems. In this paper, we present a web-based system for the interactive and collaborative exploration and inspection of arbitrary large 3D point clouds. Our approach is based on standard WebGL on the client side and is able to render 3D point clouds with billions of points. It uses spatial data structures and level-of-detail representations to manage the 3D point cloud data and to deploy out-of-core and web-based rendering concepts. By providing functionality for both, thin-client and thick-client applications, the system scales for client devices that are vastly different in computing capabilities. Different 3D point-based rendering techniques and post-processing effects are provided to enable task-specific and data-specific filtering and highlighting, e.g., based on per-point surface categories or temporal information. A set of interaction techniques allows users to collaboratively work with the data, e.g., by measuring distances and areas, by annotating, or by selecting and extracting data subsets. Additional value is provided by the system's ability to display additional, context-providing geodata alongside 3D point clouds and to integrate task-specific processing and analysis operations. We have evaluated the presented techniques and the prototype system with different data sets from aerial, mobile, and terrestrial acquisition campaigns with up to 120 billion points to show their practicality and feasibility.
Vorwort
(1994)
The Amyloid-precursor-like protein 1 (APLP1) is a neuronal type I transmembrane protein which plays a role in synaptic adhesion and synaptogenesis. Past investigations indicated that APLP1 is involved in the formation of protein-protein complexes that bridge the junctions between neighboring cells. Nevertheless, APLP1-APLP1 trans interactions have never been directly observed in higher eukaryotic cells. Here, we investigate APLP1 interactions and dynamics directly in living human embryonic kidney (HEK) cells, using fluorescence fluctuation spectroscopy techniques, namely cross-correlation scanning fluorescence correlation spectroscopy (sFCS) and Number&Brightness (N&B). Our results show that APLP1 forms homotypic trans complexes at cell-cell contacts. In the presence of zinc ions, the protein forms macroscopic clusters, exhibiting an even higher degree of trans binding and strongly reduced dynamics. Further evidence from Giant Plasma Membrane Vesicles and live cell actin staining suggests that the presence of an intact cortical cytoskeleton is required for zinc-induced cis multimerization. Subsequently, large adhesion platforms bridging interacting cells are formed through APLP1-APLP1 direct trans interactions. Taken together, our results provide direct evidence that APLP1 functions as a neuronal zinc-dependent adhesion protein and provide a more detailed understanding of the molecular mechanisms driving the formation of APLP1 adhesion platforms. Further, they show that fluorescence fluctuation spectroscopy techniques are useful tools for the investigation of protein-protein interactions at cell-cell adhesion sites.
Direct visualization of APLP1 cell-cell adhesion platforms via fluorescence fluctuation spectroscopy
(2017)
Preclinical assessment of penetration not only in intact, but also in barrier‐disrupted skin is important to explore the surplus value of novel drug delivery systems, which can be specifically designed for diseased skin. Here, we characterized physical and chemical barrier disruption protocols for short‐term ex vivo skin cultures with regard to structural integrity, physiological and biological parameters. Further, we compared the penetration of dexamethasone (Dex) in different nanoparticle‐based formulations in stratum corneum, epidermis and dermis extracts of intact vs. barrier‐disrupted skin as well as by dermal microdialysis at 6, 12 and 24 hours after topical application. Dex was quantified by liquid‐chromatography ‐ tandem‐mass spectrometry (LC‐MS/MS). Simultaneously, we investigated the Dex efficacy by interleukin (IL) analysis. Tape‐stripping (TS) and 4 hours sodium lauryl sulfate 5 % (SLS) exposure were identified as highly effective barrier disruption methods assessed by reproducible transepidermal water loss (TEWL) changes and IL‐6/8 increase which was more pronounced in SLS‐treated skin. The barrier state has also a significant impact on the Dex penetration kinetics: for all formulations, TS highly increased dermal Dex concentration despite the fact that nanocrystals quickly and effectively penetrated both, intact and barrier‐disrupted skin reaching significantly higher dermal Dex concentration after 6 hours compared to Dex cream. The surplus value of encapsulation in ethyl cellulose nanocarriers could mostly be observed when applied on intact skin, in general showing a delayed Dex penetration. Estimation of cytokines was limited due to the trauma caused by probe insertion. In summary, ex vivo human skin is a highly interesting short‐term preclinical model for the analysis of penetration and efficacy of novel drug delivery systems.
Development of a tool to identify intensive care patients at risk of meropenem therapy failure
(2018)
The problem of atmospheric emission from OH molecules is a long standing problem for near-infrared astronomy. PRAXIS is a unique spectrograph which is fed by fibres that remove the OH background and is optimised specifically to benefit from OH-Suppression. The OH suppression is achieved with fibre Bragg gratings, which were tested successfully on the GNOSIS instrument. PRAXIS uses the same fibre Bragg gratings as GNOSIS in its first implementation, and will exploit new, cheaper and more efficient, multicore fibre Bragg gratings in the second implementation. The OH lines are suppressed by a factor of similar to 1000, and the expected increase in the signal-to-noise in the interline regions compared to GNOSIS is a factor of similar to 9 with the GNOSIS gratings and a factor of similar to 17 with the new gratings. PRAXIS will enable the full exploitation of OH suppression for the first time, which was not achieved by GNOSIS (a retrofit to an existing instrument that was not OH-Suppression optimised) due to high thermal emission, low spectrograph transmission and detector noise. PRAXIS has extremely low thermal emission, through the cooling of all significantly emitting parts, including the fore-optics, the fibre Bragg gratings, a long length of fibre, and the fibre slit, and an optical design that minimises leaks of thermal emission from outside the spectrograph. PRAXIS has low detector noise through the use of a Hawaii-2RG detector, and a high throughput through a efficient VPH based spectrograph. PRAXIS will determine the absolute level of the interline continuum and enable observations of individual objects via an IFU. In this paper we give a status update and report on acceptance tests.
Live migration is an important feature in modern software-defined datacenters and cloud computing environments. Dynamic resource management, load balance, power saving and fault tolerance are all dependent on the live migration feature. Despite the importance of live migration, the cost of live migration cannot be ignored and may result in service availability degradation. Live migration cost includes the migration time, downtime, CPU overhead, network and power consumption. There are many research articles that discuss the problem of live migration cost with different scopes like analyzing the cost and relate it to the parameters that control it, proposing new migration algorithms that minimize the cost and also predicting the migration cost. For the best of our knowledge, most of the papers that discuss the migration cost problem focus on open source hypervisors. For the research articles focus on VMware environments, none of the published articles proposed migration time, network overhead and power consumption modeling for single and multiple VMs live migration. In this paper, we propose empirical models for the live migration time, network overhead and power consumption for single and multiple VMs migration. The proposed models are obtained using a VMware based testbed.
No other means of communication determines through its seemingly unrestricted possibilities our everyday life more than the internet. From the mid-90s onwards, more and more technical advancements in the field of communication appear on the market, which in turn call for new terminology. In the first place, it is the internet (essentially based on the interaction between users and experts), which requires effective nomenclature in order to mediate between lay users and their restricted knowledge on the one, and experts and their sophisticated terminology on the other hand. At the interface between the new and complex realities and the need for simple linguistic access, a huge quantity of metaphoric denominations is used, making abstract innovations more comprehensible. Metaphor in the internet discourse serves to "reduce verticality" (Stenschke 2006) between specialized terminology and common language. The paper deals with metaphors based on spatial concepts. Space and spatiality play a key role in cognitive theories of metaphor as these theories themselves (according to Lakoff/Johnson 1980) are often based on the application of spatial concepts to non-spatial relations. After describing spatial concepts in general (referring to the internet), the paper explores which kind of metaphor takes advantage of the complexity present in the internet and how the medial space is linguistically recaptured in terms of spatial perception.
Conclusion
(2016)
This chapter revisits the role of the new modes of governance in areas of limited statehood. First, it states that there is no linear relationship between degrees of statehood and the overall effectiveness of new modes of sustainability governance. Second, the chapter states that, in most of the cases, national governments are hesitant or even actively hamper the development of new modes of governance. Third, it shows that the absence of the shadow of hierarchy can indeed lead to ineffective new modes of governance. However, the shadow of hierarchy does not necessarily need to be cast by states. Finally, the author reviews the complexities involved in participatory practices, stressing the importance of institutional structures and knowledgeable brokers. The chapter concludes by outlining fields for future research.
This chapter investigates the trajectory of establishing the Forest Stewardship Council (FSC) in the early 1990s as the first private transnational certification organization with an antagonistic stakeholder body. Its main contribution is a micro-analysis of the founding assembly in 1993. By investigating the role of brokers within the negotiation as one institutional scope condition for ‘arguing’ having occurred, the chapter adopts a dramaturgical approach. It contends that the authority of brokers is not necessarily institutionally given, but needs to be gained: brokers have to prove situationally that their knowledge is relevant and that they are speaking impartially in the interest of progress rather than their own. The chapter stresses the importance of procedural knowledge which brokers provide in contrast to policy knowledge.
Introduction
(2016)
The Paris Agreement for Climate Change or the Sustainable Development Goals (SDGs) rely on new modes of governance for implementation. Indeed, new modes of governance such as market-based instruments, public-private partnerships or multi-stakeholder initiatives have been praised for playing a pivotal role in effective and legitimate sustainability governance. Yet, do they also deliver in areas of limited statehood? States such as Malaysia or the Dominican Republic partly lack the ability to implement and enforce rules; their statehood is limited. This introduction provides the analytical framework of this volume and critically examines the performance of new modes of governance in areas of limited statehood, drawing on the book’s in-depth case studies on issues of climate change, biodiversity, and health.
Basándose en el conjunto de la obra humboldtiana, desde sus comienzos hasta el Cosmos, este dossier trata de destacar la orientación cosmopolita del sabio prusiano así como, sobre todo, el fundamento americano de sus enfoques. El continente americano, para Humboldt, representa la diversidad de lo pensable y la multirrelacionalidad de lo imaginable: la llave para entender su cosmovisión.
The Internet can be considered as the most important infrastructure for modern society and businesses. A loss of Internet connectivity has strong negative financial impacts for businesses and economies. Therefore, assessing Internet connectivity, in particular beyond their own premises and area of direct control, is of growing importance in the face of potential failures, accidents, and malicious attacks. This paper presents CORIA, a software framework for an easy analysis of connectivity risks based on large network graphs. It provides researchers, risk analysts, network managers and security consultants with a tool to assess an organization's connectivity and paths options through the Internet backbone, including a user-friendly and insightful visual representation of results. CORIA is flexibly extensible in terms of novel data sets, graph metrics, and risk scores that enable further use cases. The performance of CORIA is evaluated by several experiments on the Internet graph and further randomly generated networks.
Skeletal muscle alterations during aging lead to dysfunctional metabolism, correlating with frailty and early mortality. The loss of proteostasis is a hallmark of aging. Whether proteostasis loss plays a role in muscle aging remains elusive. To address this question we collected muscles, Soleus (SOL, type I) and Extensor digitorum longus (EDL, type II), from young (4 months) and old (25 months) C57BL/6 mice and evaluated the proteasomal system. Initial work showed decreased 26 S activity in old SOL. EDL displayed lower proteasomal activity in both ages compared to any of the SOL ages. Moreover, in order to understand if during aging there is the so-called “fiber switch from fast-to-slow”, we performed western blots against sMHC and fMHC (slow and fast myosin heavy chain, respectively). Preliminary results suggest that young SOL is composed by slow twitch fibers but also contains fast twitch fibers, while young EDL seems to be mostly composed by fast twitch fibers that level down during aging, suggesting the switch. As a conclusion, EDL seems to have less proteasomal activity, however, if this is a contributor or a consequence to the muscle fiber switch during aging still needs further investigation.
In this paper, we consider counting and projected model counting of extensions in abstract argumentation for various semantics. When asking for projected counts we are interested in counting the number of extensions of a given argumentation framework while multiple extensions that are identical when restricted to the projected arguments count as only one projected extension. We establish classical complexity results and parameterized complexity results when the problems are parameterized by treewidth of the undirected argumentation graph. To obtain upper bounds for counting projected extensions, we introduce novel algorithms that exploit small treewidth of the undirected argumentation graph of the input instance by dynamic programming (DP). Our algorithms run in time double or triple exponential in the treewidth depending on the considered semantics. Finally, we take the exponential time hypothesis (ETH) into account and establish lower bounds of bounded treewidth algorithms for counting extensions and projected extension.
Short period double degenerate white dwarf (WD) binaries with periods of less than similar to 1 day are considered to be one of the likely progenitors of type Ia supernovae. These binaries have undergone a period of common envelope evolution. If the core ignites helium before the envelope is ejected, then a hot subdwarf remains prior to contracting into a WD. Here we present a comparison of two very rare systems that contain two hot subdwarfs in short period orbits. We provide a quantitative spectroscopic analysis of the systems using synthetic spectra from state-of-the-art non-LTE models to constrain the atmospheric parameters of the stars. We also use these models to determine the radial velocities, and thus calculate dynamical masses for the stars in each system.
Prof. Fink wird zum einen auf die industriell schon lange genutzten natürlichen Polymere wie Cellulose, Stärke und Lignin eingehen, zum anderen auf neue Entwicklungen bei biobasierten Kunststoffen. Von besonderer Bedeutung ist dabei die Aufklärung von Zusammenhängen zwischen Prozessparametern, Strukturen und Eigenschaften.
Vorwort
(2019)
The interview offers a reconstruction of the German reception of Durkheim since the middle of the 1970s. Hans Joas, who was one of its major protagonists, discusses the backdrop that finally permitted a scholarly examination of Durkheim’s sociology in Germany. Focussing on his personal reception Joas then gives an account of the Durkheimian themes that inspire his work.
Just after the publication of the Theory of Communicative Action in 1981, a new generation of interpreters started a different reception of Durkheim in Germany. Hans-Peter Müller, sociologist and editor of the German translation of Leçons de sociologie, reconstructs the history of the German Durkheim’s Reception and illuminates the reasons for his interest in the French sociologist. He delivers different insights into the background which permitted the post-Habermasian generation to reach a new understanding of Durkheim’s work by enlightening the scientific and political conditions from which this new sensibility emerged.