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Institute
- Institut für Biochemie und Biologie (85)
- Hasso-Plattner-Institut für Digital Engineering GmbH (83)
- Institut für Physik und Astronomie (83)
- Institut für Geowissenschaften (61)
- Institut für Mathematik (46)
- Department Psychologie (44)
- Department Sport- und Gesundheitswissenschaften (44)
- Hasso-Plattner-Institut für Digital Engineering gGmbH (31)
- Institut für Chemie (30)
- Institut für Ernährungswissenschaft (30)
Von Koscher bis Frutarismus
(2024)
Kochbücher à la religion
(2024)
Werner Krause and Christina Gahn argue that we need to pay more attention to how the media communicates the results of opinion polls to the public. Reporting methodological details, such as margins of error, can alter citizens’ vote choices on election day. This has important implications for elections around the world
The US perennially has a far higher poverty rate than peer-rich democracies.1 This high poverty rate in the US presents an enormous challenge to population health given that considerable research demonstrates that being in poverty is bad for one’s health.2 Despite valuable contributions of prior research on income and mortality, the quantity of mortality associated with poverty in the US remains uknown. In this cohort study, we estimated the association between poverty and mortality and quantified the proportion and number of deaths associated with poverty.
Das Projekt beschäftigt sich mit der visuellen Wirkungsdimension von Lyrik und der Möglichkeit ihrer analytischen Beschreibung. Dafür werden die Anordnung von Versen und Wörtern, Auszeichnungen und andere typographische Strukturen von nicht experimentellen Gedichten seit Ende des 18. Jahrhunderts im Rahmen von Modellanalysen untersucht.
Factory Innovation Award
(2023)
Einmal mehr brachte die Hannover Messe die Spitzen der Industrie zusammen, um die wegweisenden Innovationen des Jahres mit dem begehrten Factory Innovation Award 2023 zu ehren. Dieser renommierte Preis, der erstmals auf der Industrial Transformation Stage verliehen wurde, markierte den Höhepunkt einer spannungsgeladenen Veranstaltung.
1. Der Staat ist nach dem Krankenhausfinanzierungsgesetz und dem Grundgesetz zur funktionsgerechten Finanzierung der in den Krankenhausplan eines Landes aufgenommenen (Plan-)Krankenhäuser verpflichtet. Um die Versorgung der Bevölkerung mit Krankenhausbehandlung sicherzustellen, müssen die Länder sämtliche bei wirtschaftlicher Betriebsführung notwendigen Investitionskosten der Plankrankenhäuser decken (§ 1 Abs. 1, § 4 Nr. 1, § 9 Abs. 5 KHG, Art. 12 Abs. 1 GG). Es gilt das Kostendeckungsprinzip. Die Sozialleistungsträger müssen Krankenhäuser durch leistungsgerechte Erlöse aus den Pflegesätzen wirtschaftlich sichern (§ 1 Abs. 1, § 4 Nr. 2 KHG, Art. 12 Abs. 1 GG).
2. Die Vergütung der Krankenhäuser durch die Sozialleistungsträger ist unzureichend. Die Fallpauschalen des DRG-Systems bleiben hinter dem zur Betriebskostenfinanzierung erforderlichen Maß zurück, weil die anhaltenden Preissteigerungen in den Landesbasisfallwerten nicht ausreichend berücksichtigt sind.
3. Die Länder kommen ihrer gesetzlichen und verfassungsrechtlichen Verpflichtung zur Übernahme der notwendigen Investitionskosten der Plankrankenhäuser seit vielen Jahren ungenügend nach.
4. Vor allem Kommunen, aber auch Länder gewähren staatlichen Krankenhäusern Ausgleichsleistungen wie Jahresfehlbetragsdeckungen, Investitions- und Betriebskostenzuschüsse, Eigenkapitalerhöhungen, zinsvergünstigte Darlehen, kostenfreie Bürgschaften und Liquiditätshilfen (sog. Defizitausgleich). Eine weitere Form des selektiven Defizitausgleichs ist die Übernahme der Kosten von Entlastungstarifverträgen staatlicher Kliniken durch Länder. Freigemeinnützige und private Krankenhäuser erhalten bislang keinen solchen Defizitausgleich.
5. Der selektive Defizitausgleich eines Landes nur für staatliche Krankenhäuser verstößt gegen das gesetzliche (§ 1 Abs. 2 S. 1 und 2 KHG) und verfassungsrechtliche (Art. 12 Abs. 1 i.V.m. Art. 3 Abs. 1 GG) Gebot der Gleichbehandlung der Plankrankenhäuser (Prinzip der Trägervielfalt). Er ist des halb rechts- und verfassungswidrig.
6. Ein selektiver Defizitausgleich von Kommunen nur für eigene (kommunale) Krankenhäuser verstößt gegen das landesgesetzliche Prinzip der Trägervielfalt und das Gleichbehandlungsgebot des Art. 3 Abs. 1 GG und ist somit unzulässig.
7. Auf eigene Krankenhäuser beschränkte Ausgleichsleistungen von Kommunen oder Ländern sind eine unzulässige Beihilfe i.S.d. Art. 107 Abs. 1 AEUV und deshalb unvereinbar mit dem EU-Beihilferecht. Das gilt sowohl, wenn staatliche Krankenhäuser Ausgleichsleistungen für die Versorgung der Bevölkerung mit Krankenhausbehandlung (s. § 109 Abs. 1 S. 1 und 2, Abs. 4 S. 2 SGB V) erhalten, als auch, wenn der Ausgleich „Gegenleistung“ für eine hoheitlich auferlegte Betriebspflicht ist. Eine wirksame Durchsetzung des EU-Beihilferechts und effektiver Rechtsschutz für nicht begünstigte freigemeinnützige und private Krankenhäuser erfordern Transparenz und eine entsprechende Veröffentlichung der Betrauungsakte der Länder und Kommunen.
8. Ein Defizitausgleich für alle in den Krankenhausplan eines Landes aufgenommenen (Plan-)Krankenhäuser ist beihilferechtlich zulässig. Da sämtliche Plankrankenhäuser Dienstleistungen von allgemeinem wirtschaftlichen Interesse (DAWI) erbringen (gesetzliche Pflicht zur Versorgung der Bevölkerung mit Krankenhausbehandlung), müssen sie nach dem EU-Beihilferecht bei staatlichen Ausgleichsleistungen für die Erfüllung der Versorgungspflicht gleichbehandelt werden. Art. 107 Abs. 1 AEUV ist entsprochen, wenn entweder ein selektiver Defizitausgleich für staatliche Plankrankenhäuser unterbleibt bzw. aufgehoben und rückabgewickelt wird oder alle – staatlichen, freigemeinnützigen und privaten Plankrankenhäuser – gleichgefördert werden.
9. Diese nach dem EU-Beihilferecht bestehende Wahlmöglichkeit kann den Ländern nach nationalem Recht verschlossen sein. Ein Ausgleich der Länder für Investitionskosten ist prinzipiell erforderlich, um der gesetzlichen Verpflichtung aus § 1 Abs. 1, § 4 Nr. 1, § 9 Abs. 5 KHG nachzukommen und die notwendigen Investitionskosten der Plankrankenhäuser unter Beachtung betriebswirtschaftlicher Grundsätze zu decken. Freigemeinnützige und private Krankenhäuser haben Anspruch auf Ausgleichsleistungen zur Investitionskostendeckung bereits wegen des gesetzlichen Gebots funktionsgerechter Finanzierung (§ 8 Abs. 1 S. 1 KHG) und aus ihrem Grundrecht der Berufsfreiheit (Art. 12 Abs. 1 GG). Ihnen kann dieser Anspruch aber auch wegen des gesetzlichen und verfassungsrechtlichen Gebots der Gleichbehandlung zustehen. Gewähren die Länder staatlichen Plankrankenhäusern bei wirtschaftlicher Betriebsführung Ausgleichsleistungen, um ihrer Verpflichtung zur Übernahme notwendiger Investitionskosten nachzukommen, müssen sie freigemeinnützigen und privaten Plankrankenhäusern nach dem Gleichbehandlungsgebot einen entsprechenden Ausgleich zahlen (§ 8 Abs. 1 S. 1 i.V.m. § 1 Abs. 2 S. 1 und 2 KHG, Art. 12 Abs. 1 i.V.m. Art. 3 Abs. 1 GG). Einer nach nationalem Recht gebotenen, gleichen Förderung aller Plankrankenhäuser steht das EU-Beihilferecht nicht entgegen.
10. Die Kommunen sind dagegen nach nationalem Recht (über die Krankenhausumlage hinaus) nicht zur Krankenhausfinanzierung verpflichtet. Sie entscheiden gem. Art. 28 Abs. 2 S. 1 GG (Gemeinden) bzw. gem. Art. 28 Abs. 2 S. 2 GG i.V.m. Landeskrankenhausrecht (Gemeindeverbände) eigenverantwortlich, ob und in welchem Umfang sie Plankrankenhäuser unter Beachtung des Wirtschaftlichkeitsgebots finanziell unterstützen (Investitions- und Betriebskosten). Dementsprechend engt das nationale Recht die nach EU-Beihilferecht bestehende Wahlmöglichkeit für Kommunen nicht ein, selektive Ausgleichsleistungen für kommunale Krankenhäuser zu unterlassen bzw. aufzuheben und rückabzuwickeln oder sie so umzugestalten, dass freigemeinnützige und private Plankrankenhäuser die gleiche Förderung erhalten. Scheidet allerdings eine Rückzahlung der von Kommunen an ihre Krankenhäuser gezahlten Finanzmittel wegen tatsächlicher Unmöglichkeit aus, wird dem EU-Beihilferecht nur entsprochen, wenn die Kommunen freigemeinnützige und private Plankrankenhäuser gleichermaßen fördern.
11. Ohne eine Nachzahlung der in den letzten Jahren unterbliebenen Förderung durch die Sozialleistungsträger und die Länder ist die anstehende Krankenhausreform für die Krankenhäuser nicht zu bewältigen. Um die geplante Umstellung auf neue Versorgungslevel und Leistungsgruppen vornehmen und die hiermit verbundenen kostenintensiven Umstrukturierungsprozesse leisten zu können, muss die infolge unzureichender Krankenhausfinanzierung entstandene Unterfinanzierung der Krankenhäuser vor der Reform behoben werden. Die Forderungen nach „Vorschaltgesetzen“ sind daher berechtigt.
Rechts nur noch die Wand?
(2023)
Die DDR im Plural
(2023)
Die Macht der Sonntagsfrage
(2023)
Für das Jahr 2024 sind entscheidende Wahlen geplant – unter ihnen die
US-Präsidentschaftswahl und die Wahlen zum Europäischen Parlament. In
Deutschland werden in Brandenburg, Sachsen und Thüringen die Landtage
gewählt. Wahlumfragen, insbesondere die Sonntagsfrage, sind zu einem
integralen Bestandteil von Wahlkämpfen geworden; gleichzeitig steht auch
deren Zuverlässigkeit im Zentrum medialer Aufmerksamkeit. Eine Debatte über
die Kommunikation und Darstellung von Meinungsumfragen ist in Deutschland
dringend notwendig. Eine bindende Selbstverpflichtung der Umfrageinstitute und
Medienhäuser wäre eine vielversprechende Lösung.
Künstliche Intelligenz (KI) gewinnt in zahlreichen Branchen rasant an Bedeutung und wird zunehmend auch in Enterprise Resource Planning (ERP)-Systemen als Anwendungsbereich erschlossen. Die Idee, dass Maschinen die kognitiven Fähigkeiten des Menschen imitieren können, indem Wissen durch Lernen auf Basis von Beispielen in Daten, Informationen und Erfahrungen generiert wird, ist heute ein Schlüsselelement der digitalen Transformation. Jedoch charakterisiert der Einsatz von KI in ERP-System einen hohen Komplexitätsgrad, da die KI als Querschnittstechnologie zu verstehen ist, welche in unterschiedlichen Unternehmensbereichen zum Einsatz kommen kann. Auch die Anwendungsgrade können sich dabei erheblich voneinander unterscheiden. Um trotz dieser Komplexität den Einsatz der KI in ERP-Systemen erfassen und systembezogen vergleichen zu können, wurde im Rahmen dieser Studie ein Reifegradmodell entwickelt. Dieses bildet die Ausgangsbasis zur Ermittlung der KI-Reife in ERP-Systemen und grenzt dabei die folgenden vier KI- bzw. systembezogenen Ebenen voneinander ab: 1) Technische Möglichkeiten, 2) Datenreife, 3) Funktionsreife und 4) Erklärfähigkeit des Systems.
So richtig schlüssig finden die Medienrechtler Marcus Schladebach und Hans-Christian Gräfe den Vorschlag der EU-Kommission für den Europäischen Media Freedom Act nicht. Unter einer überpathetischen Überschrift regelt er fiktive Fragen, die eigentlich keiner Regelung bedürfen. Zudem ohne Kompetenz auf dem Gebiet der Medienpolitik.
The sky is not the limit
(2022)
Most flowering plants are hermaphrodites, with flowers having both male and female reproductive organs. One widespread adaptation to limit self-fertilization is self-incompatibility (SI), where self-pollen fails to fertilize ovules.(1,2) In homomorphic SI, many morphologically indistinguishable mating types are found, although in heteromorphic SI, the two or three mating types are associated with different floral morphologies.(3-6) In heterostylous Primula, a hemizygous supergene determines a short-styled S-morph and a long-styled L-morph, corresponding to two different mating types, and full seed set only results from inter morph crosses.(7-9) Style length is controlled by the brassinosteroid (BR)-inactivating cytochrome P450 CYP734A50,(10) yet it remains unclear what defines the male and female incompatibility types. Here, we show that CYP734A50 also determines the female incompatibility type. Inactivating CYP734A50 converts short S-morph styles into long styles with the same incompatibility behavior as L-morph styles, and this effect can be mimicked by exogenous BR treatment. In vitro responses of S-and L-morph pollen grains and pollen tubes to increasing BR levels could only partly explain their different in vivo behavior, suggesting both direct and indirect effects of the different BR levels in S-versus L-morph stigmas and styles in controlling pollen performance. This BR-mediated SI provides a novel mechanism for preventing self-fertilization. The joint control of morphology and SI by CYP734A50 has important implications for the evolutionary buildup of the heterostylous syndrome and provides a straightforward explanation for why essentially all of the derived self-compatible homostylous Primula species are long homostyles.(11)
À partir des travaux des ethnologues qui ont décrit le fonctionnement des sociétés paysannes de l’Ancien Régime, nous montrons dans cet article comment le récit de l’enfance bretonne de Chateaubriand dans les ‚Mémoires d’outre-tombe‘ obéit à une logique initiatique qui donne à l’animal un rôle de premier plan. Transformée en véritable „aventure“, la capture des oiseaux devient pour l’enfant l’occasion de forger son caractère et de découvrir le sens de l’honneur, tandis que la contemplation de leur envol éveille en lui le goût des voyages qu’il n’a pas encore la possibilité d’assouvir. À Combourg, chouettes et chat noir peuplent les nuits de l’enfant et l’obligent à dompter ses peurs. Quant au cheval, que Chateaubriand a mal appris à maîtriser, il devient sous sa plume l’emblème d’une époque révolue dominée par les privilèges de l’aristocratie et le signe de l’inadaptation des derniers rois de France. Il restera à l’écrivain à s’emparer de cette familiarité avec le monde animal pour nourrir son imaginaire et sa sensibilité de plus en plus grande au sort que lui réserve la société.
Filbert, Alfred
(2022)
Bibliographie-Eintrag: Der Jurist Alfred Filbert gehörte von 1935 bis 1945 zu den Funktionseliten im Hauptamt des Sicherheitsdienstes des Reichsführers-SS und im Reichssicherheitshauptamt. 1941 verantwortete er als Leiter des SS-Einsatzkommandos 9 die Ermordung von rund 18 000 Juden. 1945 untergetaucht, wurde er 1959 verhaftet, 1962 zu lebenslanger Haft verurteilt und 1975 vorzeitig entlassen.
From victims to activists
(2022)
The politics of fear
(2022)
Steigende Mieten?
(2022)
Vor dem Hintergrund rasant steigender Mieten in deutschen Großstädten untersuchen wir in einer neuen Studie die Auswirkungen von Gentrifizierung sowie von politischen Gegenmaßnahmen auf unterschiedliche Einkommensgruppen anhand eines quantitativen Modells für Berlin. Wir finden, dass eine Mietpreisbindung (wie der „Mietendeckel“) allen Haushalten, vor allem aber den ärmeren Haushalten, schadet. Andere Maßnahmen wie Neubau oder direkte Subventionen schneiden besser ab.
This special issue, "Concrete constraints of abstract concepts", addresses the role of concrete determinants, both external and internal to the human body, in acquisition, processing and use of abstract concepts while at the same time presenting to the readers an overview of methods used to assess their representation.
Care work 4.0
(2022)
Care-Berufe verändern sich durch demographische, technologische und wirtschaftliche Entwicklungen. Zuletzt erhöhen auch gesundheitspolitische Herausforderungen und die COVID-19 Maßnahmenpolitik den Druck auf das Sozial- und Gesundheitssystem. Dadurch befindet sich die bezahlte Care-Arbeit im berufsstrukturellen Wandel, d. h. es entstehen neue Bedingungen für und Anforderungen an diese Tätigkeiten, die in Österreich mehrheitlich von Frauen ausgeübt werden.
Background and Aims: Ostarek et al. (2019) claimed a conclusive
demonstration that language comprehension relies profoundly on
visual simulations. They presented participants with visual noise during sentence-picture verification (SPV) and measured lateralized button response speed. The authors selectively eliminated the classical congruency effect (faster yes decisions when pictures match the objects implied by the sentences) with ‘‘high level’’ noise made from images of other objects. However, that visual noise included tool pictures, known to activate lateralized motor affordances. Moreover, some of their sentences described motor actions. This raises the question whether motor simulation may have contaminated their results.
Methods: Replicating Ostarek et al. (2019), 33 right-handed
participants performed SPV but either without visual noise or while viewing (a) only left-handled or (b) only right-handled or (c) alternatingly left- and right-handled tools. Accuracy and reaction times of manual yes responses were analyzed. Additionally, hand-relatedness of sentences was rated.
Results: Replicating Ostarek et al. (2019), the classical SPV congruency effect appeared without noise and vanished when alternatingly handled tools were presented. Crucially, it reappeared when noise objects were consistently either left- or righthandled. Higher hand-relatedness of sentence content reduced SPV performance and accuracy was lower with right-handled noise.
Conclusion: First, we demonstrated an interaction between motor-
related language, visual affordances and motor responses in SPV.
This result supports the embodied view of language processing.
Second, we identified a motor process not previously known in SPV. This extends our understanding of mental simulation and calls for methodological controls in future studies.
Playful Classics
(2021)
Teen dating violence
(2021)
Editorial
(2021)
Berufsbildung für nachhaltige Entwicklung (BBNE) ist (nicht nur) für die Berufs- und Wirtschaftspädagogik ein komplexes, anregendes Forschungsfeld. Zugleich stellt sie für die Lehrer:innenbildung eine herausfordernde Orientierungsaufgabe dar. Dabei kann eine Transdisziplinarität als Basis gemeinsamer Forschungs- und Erkenntnisprozesse der Berufs- und Wirtschaftspädagogik und der Praxis als unumgängliche Voraussetzung zur Annäherung an eine BBNE angesehen werden. Ein Weg, der zukünftigen Berufsschullehrkräften einen praxisorientierten Zugang zur BBNE eröffnen kann, wird in dieser Ausgabe der bwp-Schriften aus unterschiedlichen Perspektiven beschrieben.
Don’t settle for less
(2021)
Immune to COVID?
(2021)
History without borders
(2020)
Planstadt Doberlug
(2020)
Eccentric exercises (ECC) induce reversible muscle damage, delayed-onset muscle soreness and an inflammatory reaction that is often followed by a systemic anti-inflammatory response. Thus, ECC might be beneficial for treatment of metabolic disorders which are frequently accompanied by a low-grade systemic inflammation. However, extent and time course of a systemic immune response after repeated ECC bouts are poorly characterized.
PURPOSE: To analyze the (anti-)inflammatory response after repeated ECC loading of the trunk.
METHODS: Ten healthy participants (33 ± 6 y; 173 ± 14 cm; 74 ± 16 kg) performed three isokinetic strength measurements of the trunk (concentric (CON), ECC1, ECC2, each 2 wks apart; flexion/extension, velocity 60°/s, 120s MVC). Pre- and 4, 24, 48, 72, 168h post-exercise, muscle soreness (numeric rating scale, NRS) was assessed and blood samples were taken and analyzed [Creatine kinase (CK), C-reactive protein (CRP), Interleukin-6 (IL-6), IL-10, Tumor necrosis factor-α (TNF-α)]. Statistics were done by Friedman‘s test with Dunn‘s post hoc test (α=.05).
RESULTS: Mean peak torque was higher during ECC1 (319 ± 142 Nm) than during CON (268 ± 108 Nm; p<.05) and not different between ECC1 and ECC2 (297 ± 126 Nm; p>.05). Markers of muscle damage (peaks post-ECC1: NRS 48h, 4.4±2.9; CK 72h, 14407 ± 19991 U/l) were higher after ECC1 than after CON and ECC2 (p<.05). The responses over 72h (stated as Area under the Curve, AUC) were abolished after ECC2 compared to ECC1 (p<.05) indicating the presence of the repeated bout effect. CRP levels were not changed. IL-6 levels increased 2-fold post-ECC1 (pre: 0.5 ± 0.4 vs. 72h: 1.0 ± 0.8 pg/ml). The IL-6 response was enhanced after ECC1 (AUC 61 ± 37 pg/ml*72h) compared to CON (AUC 33 ± 31 pg/ml*72h; p<.05). After ECC2, the IL-6 response (AUC 43 ± 25 pg/ml*72h) remained lower than post-ECC1, but the difference was not statistically significant. Serum levels of TNF-α and of the anti-inflammatory cytokine IL-10 were below detection limits. Overall, markers of muscle damage and immune response showed high inter-individual variability.
CONCLUSION: Despite maximal ECC loading of a large muscle group, no anti-inflammatory and just weak inflammatory responses were detected in healthy adults. Whether ECC elicits a different reaction in inflammatory clinical conditions is unclear.
Eccentric (ECC) exercises might cause muscle damage, characterized by delayed-onset muscle soreness, elevated creatine kinase (CK) levels and local muscle oedema, shown by elevated T2 times in magnet resonance imaging (MRI) scans. Previous research suggests a high inter-individual difference regarding these systemic and local responses to eccentric workload. PURPOSE: To analyze ECC exercise-induced muscle damage in lumbar paraspinal muscles assessed via MRI. METHODS: Ten participants (3f/7m; 33±6y; 174±8cm; 71±12kg) were included in the study. Quantitative paraspinal muscle constitution of M. erector spinae and M. multifidius were assessed in supine position before and 72h after an intense eccentric trunk exercise bout in a mobile 1.5 tesla MRI device. MRI scans were recorded on spinal level L3 (T2-weighted TSE echo sequences, 11 slices, 2mm slice thickness, 3mm gap, echo times: 20, 40, 60, 80, 100ms, TR time: 2500ms). Muscle T2 times were calculated for manually traced regions of interest of the respective muscles with an imaging software. The exercise protocol was performed in an isokinetic device and consisted of 120sec alternating ECC trunk flexion-extension with maximal effort. Venous blood samples were taken before and 72h after the ECC exercise. Descriptive statistics (mean±SD) and t-testing for pre-post ECC exercises were performed. RESULTS: T2 times increased from pre- to post-ECC MRI measurements from 55±3ms to 79±28ms in M. erector spinae and from 62±5ms to 78±24ms in M. multifidius (p<0.001). CK increased from 126±97 U/L to 1447±20579 U/L. High SDs of T2 time and CK in post-ECC measures could be due to inter-individual reactions to ECC exercises. 3 participants showed high local and systemic reactions (HR) with T2 time increases of 120±24% (M. erector spinae) and 73±50% (M. multifidius). In comparison, the remaining 7 participants showed increases of 11±12% (M. erector spinae) and 7±9% (M. multifidius) in T2 time. Mean CK increased 9.5-fold in the 3 HR subjects compared with the remaining 7 subjects. CONCLUSIONS: The 120sec maximal ECC trunk flexion-extension protocol induced high amounts of muscle damage in 3 participants. Moderate to low responses were found in the remaining 7 subjects, assuming that inter-individual predictors play a role regarding physiological responses to ECC workload.
PURPOSE: To determine the feasibility of upright compared to supine MRI measurements to determine characteristics of the lumbar spine in AA with spondylolisthesis.
METHODS: Ten AA (n=10; m/f: 4/6; 14.5±1.7y; 163±7cm; 52±8kg) from various sports, diagnosed with spondylolisthesis grade I-II Meyerding confirmed by x-ray in standing lateral view, were included. Open low-field MRI images (0.25 Tesla) in upright (82°) and supine (0°) position were evaluated by two observers. Medical imaging software was used to measure the anterior translation (AT, mm), lumbosacral joint angle (LSJA, °) and lordosis angle (LA, °). Reliability was analyzed by the intra-rater correlation coefficient (ICC) and standard error of measurements (SEM).
RESULTS: Due to motion artifacts during upright position, measures of three participants had to be excluded. Between observers, AT ranged from 4.2±2.7mm to 5.5±1.9mm (ICC=0.94, SEM=0.6mm) in upright and from 4.9±2.4mm to 5.9±3.0mm (ICC=0.89, SEM=0.9mm) in supine position. LSJA varied from 5.1±2.2° to 7.3±1.5° (ICC=0.54, SEM=1.5°) in upright and from 9.8±2.5° to 10±2.4° (ICC=0.73, SEM=1.1°) in supine position. LA differed from 58.8±14.6° to 61.9±6° (ICC=0.94, SEM=1.19°) in upright and from 51.9±11.7° to 52.6±11.1° (ICC=0.98, SEM=1.59°) in supine position.
CONCLUSIONS: Determination of AT and LA showed good to excellent reliability in both, upright and supine position. In contrast, reliability of LSJA had only moderate to good correlation
between observers and should therefore be interpreted with caution. However, motion artifacts should be taken into consideration during upright imaging procedures.
Climate change entails an intensification of extreme weather events that can potentially trigger socioeconomic and energy system disruptions. As we approach 1 degrees C of global warming we should start learning from historical extremes and explicitly incorporate such events in integrated climate-economy and energy systems models.
Der Potsdam Grievance Statistics File (PGSF) ist eine historische Datensammlung von Beschwerden, sog. Eingaben, die in der DDR von deren Bürgern eingereicht wurden. Die Eingaben wurden schriftlich oder mündlich gestellt und waren an staatliche Institutionen gerichtet. Der Staat zählte diese Eingaben und kategorisierte sie in Eingabenstatistiken.
Der PGSF enthält Eingabenstatistiken des Zeitraums 1970–1989 einer Wahrscheinlichkeitsstichprobe von im Jahr 1990 existierenden Kreisen. Zusätzlich finden sich Eingabenstatistiken eines Convenience-Samples von Kreisen aus dem Zeitraum 1970–1989.
Der Potsdam Grievance Statistics File (PGSF) ist eine historische Datensammlung von Beschwerden, sog. Eingaben, die in der DDR von deren Bürgern eingereicht wurden. Die Eingaben wurden schriftlich oder mündlich gestellt und waren an staatliche Institutionen gerichtet. Der Staat zählte diese Eingaben und kategorisierte sie in Eingabenstatistiken.
Der PGSF enthält Eingabenstatistiken des Zeitraums 1970–1989 einer Wahrscheinlichkeitsstichprobe von im Jahr 1990 existierenden Kreisen. Zusätzlich finden sich Eingabenstatistiken eines Convenience-Samples von Kreisen aus dem Zeitraum 1970–1989.
Leben in der ehemaligen DDR
(2020)
Xenikoudakis et al. report a partial mitochondrial genome of the extinct giant beaver Castoroides and estimate the origin of aquatic behavior in beavers to approximately 20 million years. This time estimate coincides with the extinction of terrestrial beavers and raises the question whether the two events had a common cause.
Reinhard Hujer
(2020)
Chronic ankle instability (CAI) is not only an ankle issue, but also affects sensorimotor system. People with CAI show altered muscle activation in proximal joints such as hip and knee. However, evidence is limited as controversial results have been presented regarding changes in activation of hip muscles in CAI population. PURPOSE: To investigate the effect of CAI on activity of hip muscles during normal walking and walking with perturbations. METHODS: 8 subjects with CAI (23 ± 2 years, 171 ± 7 cm and 65 ± 4 kg) and 8 controls (CON) matched by age, height, weight and dominant leg (25 ± 3 years, 172 ± 7 cm and 65 ± 6 kg) walked shoed on a split-belt treadmill (1 m/s). Subjects performed 5 minutes of baseline walking and 6 minutes walking with 10 perturbations (at 200 ms after heel contact with 42 m/s2 deceleration impulse) on each side. Electromyography signals from gluteus medius (Gmed) and gluteus maximus (Gmax) were recorded while walking. Muscle amplitudes (Root Mean Square normalized to maximum voluntary isometric contraction) were calculated at 200 ms before heel contact (Pre200), 100 ms after heel contact (Post100) during normal walking and 200 ms after perturbations (Pert200). Differences between groups were examined using Mann Whitney U test and Bonferroni correction to account for multiple testing (adjust α level p≤ 0.0125). RESULT: In Gmed, CAI group showed lower muscle amplitude than CON group after heel contact (Post100: 18±7 % and 47±21 %, p< .01) and after walking perturbations ( 31±13 % and 62±26 %, p< .01), but not before heel contact (Pre200: 5±2 % and 11±10 %, p= 0.195). In Gmax, no difference was found between CAI and CON groups in all three time points (Pre200: 12±5 % and 17±12 %, p= 0.574; Post100: 41±21 % and 41±13 %, p= 1.00; Pert200: 79±46 % and 62±35 %, p= 0.505). CONCLUSION: People with CAI activated Gmed less than healthy control in feedback mechanism (after heel contact and walking with perturbations), but not in feedforward mechanism (before heel contact). Less activation on Gmed may affect the balance in frontal plane and increase the risk of recurrent ankle sprain, giving way or feeling ankle instability in patients with CAI during walking. Future studies should investigate the effect of Gmed strengthening or neuromuscular training on CAI rehabilitation.
Acute ankle sprain leads in 40% of all cases to chronic ankle instability (CAI). CAI is related to a variety of motor adaptations at the lower extremities. Previous investigations identified increased muscle activities while landing in CAI compared to healthy control participants. However, it remains unclear whether muscular alterations at the knee muscles are limited to the involved (unstable) ankle or are also present at the uninvolved leg. The latter might potentially indicate a risk of ankle sprain or future injury on the uninvolved leg. Purpose: To assess if there is a difference of knee muscle activities between the involved and uninvolved leg in participants with CAI during perturbed walking. Method: 10 participants (6 females; 4 males; 26±4 years; 169±9 cm; 65±7 kg) with unilateral CAI walked on a split-belt treadmill (1m/s) for 5 minutes of baseline walking and 6 minutes of perturbed walking (left and right side, each 10 perturbations). Electromyography (EMG) measurements were performed at biceps femoris (BF) and rectus femoris (RF). EMG amplitude (RMS; normalized to MVIC) were analyzed for 200ms pre-heel contact (Pre200), 100ms post heel contact (Post100) and 200ms after perturbation (Pert200). Data was analyzed by paired t-test/Wilcoxon test based on presence or absence of normal distribution (Bonferroni adjusted α level p≤ 0.0125). Results: No statistical difference was found between involved and uninvolved leg for RF (Pre200: 4±2% and 11± 22%, respectively, p= 0.878; Post100: 10± 5 and 18±31%, p=0.959; Pert200: 6±3% and 13±24%, p=0.721) as well as for BF (Pre200: 12±7% and 11±6, p=0.576; Post100: 10±7% and 9±7%, p=0.732; Pert200: 7±4 and 7±7%, p=0.386). Discussion: No side differences in muscle activity could be revealed for assessed feedforward and feedback responses (perturbed and unperturbed) in unilateral CAI. Reduced inter-individual variability of muscular activities at the involved leg might indicate a rather stereotypical response pattern. It remains to be investigated, whether muscular control at the knee is not affected by CAI, or whether both sides adapted in a similar style to the chronic condition at the ankle.
Several overlapping crises which affected the EU during the past ten years have recently aggravated. Especially the progressing refugee crisis, the persisting financial crisis and geopolitical turmoil in the EU's neighbourhood contributed to the rise of anti-EU movements and diverse articulations of Euroscepticism. Although public opinion and mainstream political analysis have easily identified right-wing populism as one of the most important drivers, it is still doubtful if it can be equated with Euroscepticism without further ado. To date it is by no means clear how and where Euroscepticism exactly originates.
Editorial
(2020)
Background:
Inflammatory bowel disease (IBD) represents a dysregulation of the mucosal immune system. The pathogenesis of Crohn’s disease (CD) and ulcerative colitis (UC) is linked to the loss of intestinal tolerance and barrier function. The healthy mucosal immune system has previously been shown to be inert against food antigens. Since the small intestine is the main contact surface for antigens and therefore the immunological response, the present study served to analyse food-antigen-specific T cells in the peripheral blood of IBD patients.
Methods:
Peripheral blood mononuclear cells of CD, with an affected small intestine, and UC (colitis) patients, either active or in remission, were stimulated with the following food antigens: gluten, soybean, peanut and ovalbumin. Healthy controls and celiac disease patients were included as controls. Antigen-activated CD4+ T cells in the peripheral blood were analysed by a magnetic enrichment of CD154+ effector T cells and a cytometric antigen-reactive T-cell analysis (‘ARTE’ technology) followed by characterisation of the ef- fector response.
Results:
The effector T-cell response of antigen-specific T cells were compared between CD with small intestinal inflammation and UC where inflammation was restricted to the colon. Among all tested food antigens, the highest frequency of antigen-specific T cells (CD4+CD154+) was found for gluten. Celiac disease patients were included as control, since gluten has been identified as the disease- causing antigen. The highest frequency of gluten antigen-specific T cells was revealed in active CD when compared with UC, celiac disease on a gluten-free diet (GFD) and healthy controls. Ovalbuminspecific T cells were almost undetectable, whereas the reaction to soybean and peanut was slightly higher. But again, the strong- est reaction was observed in CD with small intestinal involvement compared with UC. Remarkably, in celiac disease on a GFD only
antigen-specific cells for gluten were detected. These gluten-specific T cells were characterised by up-regulation of the pro-inflammatory cytokines IFN-γ, IL-17A and TNF-α. IFN-g was exclusively elevated in CD patients with active disease. Gluten-specific T-cells expressing IL-17A were increased in all IBD patients. Furthermore, T cells of CD patients, independent of disease activity, revealed a high expression of the pro-inflammatory cytokine TNF-α.
Conclusion:
The ‘ARTE’-technique allows to analyse and quantify food antigen specific T cells in the peripheral blood of IBD patients indicating a potential therapeutic insight. These data provide evidence that small intestinal inflammation in CD is key for the development of a systemic pro-inflammatory effector T-cell response driven by food antigens.
Gomperz, Ephraim, Itzig
(2020)
Corona-Lage
(2020)
Frauenfeind, aber kein Incel
(2020)
Der Attentater von Hanau war, das verrät sein Manifest, ein Frauenfeind – aber kein Incel. Warum die Einschätzung als Incel bequem und gefährlich ist, erläutert dieser Gastbeitrag der Wissenschaftlerinnen Megan Kelly, Ann-Kathrin Rothermel und Greta Jasser, Fellows am Institute for Research on Male Supremacism (IRMS).
Based on the notion that time, space, and number are part of a generalized magnitude system, we assume that the dual-systems approach to temporal cognition also applies to numerical cognition. Referring to theoretical models of the development of numerical concepts, we propose that children's early skills in processing numbers can be described analogously to temporal updating and temporal reasoning.
Bridging the Gap
(2019)
The recent restructuring of the electricity grid (i.e., smart grid) introduces a number of challenges for today's large-scale computing systems. To operate reliable and efficient, computing systems must adhere not only to technical limits (i.e., thermal constraints) but they must also reduce operating costs, for example, by increasing their energy efficiency. Efforts to improve the energy efficiency, however, are often hampered by inflexible software components that hardly adapt to underlying hardware characteristics. In this paper, we propose an approach to bridge the gap between inflexible software and heterogeneous hardware architectures. Our proposal introduces adaptive software components that dynamically adapt to heterogeneous processing units (i.e., accelerators) during runtime to improve the energy efficiency of computing systems.
Mise-Unseen
(2019)
Creating or arranging objects at runtime is needed in many virtual reality applications, but such changes are noticed when they occur inside the user's field of view. We present Mise-Unseen, a software system that applies such scene changes covertly inside the user's field of view. Mise-Unseen leverages gaze tracking to create models of user attention, intention, and spatial memory to determine if and when to inject a change. We present seven applications of Mise-Unseen to unnoticeably modify the scene within view (i) to hide that task difficulty is adapted to the user, (ii) to adapt the experience to the user's preferences, (iii) to time the use of low fidelity effects, (iv) to detect user choice for passive haptics even when lacking physical props, (v) to sustain physical locomotion despite a lack of physical space, (vi) to reduce motion sickness during virtual locomotion, and (vii) to verify user understanding during story progression. We evaluated Mise-Unseen and our applications in a user study with 15 participants and find that while gaze data indeed supports obfuscating changes inside the field of view, a change is rendered unnoticeably by using gaze in combination with common masking techniques.
Vorwort
(2019)
Diffusion of cosmic rays (CRs) is the key process for understanding their propagation and acceleration. We employ the description of spatial separation of magnetic field lines in magnetohydrodynamic turbulence in Lazarian & Vishniac to quantify the divergence of the magnetic field on scales less than the injection scale of turbulence and show that this divergence induces superdiffusion of CR in the direction perpendicular to the mean magnetic field. The perpendicular displacement squared increases, not as the distance x along the magnetic field, which is the case for a regular diffusion, but as the x 3 for freely streaming CRs. The dependence changes to x 3/2 for the CRs propagating diffusively along the magnetic field. In the latter case, we show that it is important to distinguish the perpendicular displacement with respect to the mean field and to the local magnetic field. We consider how superdiffusion changes the acceleration of CRs in shocks and show how it decreases efficiency of the CRs acceleration in perpendicular shocks. We also demonstrate that in the case when the small-scale magnetic field is generated in the pre-shock region, an efficient acceleration can take place for the CRs streaming without collisions along the magnetic loops.
Editorial
(2019)