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Interplay between myosin II and actin dynamics in chemotactic amoeba
- The actin cytoskeleton and its response to external chemical stimuli is fundamental to the mechano-biology of eukaryotic cells and their functions. One of the key players that governs the dynamics of the actin network is the motor protein myosin II. Based on a phase space embedding we have identified from experiments three phases in the cytoskeletal dynamics of starved Dictyostelium discoideum in response to a precisely controlled chemotactic stimulation. In the first two phases the dynamics of actin and myosin II in the cortex is uncoupled, while in the third phase the time scale for the recovery of cortical actin is determined by the myosin II dynamics. We report a theoretical model that captures the experimental observations quantitatively. The model predicts an increase in the optimal response time of actin with decreasing myosin II-actin coupling strength highlighting the role of myosin II in the robust control of cell contraction.
Author details: | H. F. Hsu, Andrey KrekhovORCiDGND, Marco TarantolaORCiDGND, Carsten BetaORCiDGND, Eberhardt BodenschatzORCiDGND |
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DOI: | https://doi.org/10.1088/1367-2630/ab5822 |
ISSN: | 1367-2630 |
Title of parent work (English): | New journal of physics : the open-access journal for physics |
Publisher: | IOP Publ. Ltd. |
Place of publishing: | Bristol |
Publication type: | Article |
Language: | English |
Date of first publication: | 2019/11/28 |
Publication year: | 2019 |
Release date: | 2020/10/06 |
Tag: | actin; chemotaxis; contraction; coupling; delay differential equation; myosin II; oscillations |
Volume: | 21 |
Issue: | 11 |
Number of pages: | 15 |
Funding institution: | Max Planck SocietyMax Planck SocietyFoundation CELLEX; German Research Foundation (DFG)German Research Foundation (DFG) [SFB.937] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik und Astronomie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik |
Peer review: | Referiert |
Publishing method: | Open Access |
Open Access / Gold Open-Access | |
DOAJ gelistet |