Open Access
Refine
Year of publication
Document Type
- Article (1886)
- Postprint (1262)
- Review (70)
- Doctoral Thesis (38)
- Monograph/Edited Volume (23)
- Other (23)
- Preprint (18)
- Part of Periodical (7)
- Conference Proceeding (5)
- Master's Thesis (4)
Language
Keywords
- anomalous diffusion (28)
- Patholinguistik (22)
- Sprachtherapie (22)
- patholinguistics (22)
- embodied cognition (20)
- geistige Behinderung (20)
- mental deficiency (20)
- primary progessive aphasia (20)
- primär progessive Aphasie (20)
- speech therapy (20)
Institute
- Mathematisch-Naturwissenschaftliche Fakultät (476)
- Institut für Biochemie und Biologie (408)
- Institut für Physik und Astronomie (293)
- Institut für Geowissenschaften (252)
- Institut für Chemie (240)
- Humanwissenschaftliche Fakultät (229)
- Strukturbereich Kognitionswissenschaften (164)
- Department Psychologie (142)
- Institut für Romanistik (135)
- Department Linguistik (124)
Die Sportpsychiatrie und -psychotherapie ist ein relativ junges Arbeitsgebiet, das sich insbesondere mit zwei Schwerpunkten befasst: zum einen mit den Besonderheiten in Diagnostik und Therapie psychischer Erkrankungen bei Leistungssportler:innen sowie Bewegung und Sport in der Entstehung und Behandlung psychischer Erkrankungen. Während alle psychischen Erkrankungen prinzipiell auch bei (Leistungs‑)Sportler:innen auftreten können, gibt es darüber hinaus sport(art)spezifische psychische Erkrankungen, wie z. B. die Anorexia athletica und andere Essstörungen, die chronisch traumatische Enzephalopathie, Missbrauch und Abhängigkeit von leistungssteigernden Substanzen (Doping) oder die Muskeldysmorphie. In qualitativ hochwertigen klinischen Studien konnte die therapeutische Wirksamkeit von Bewegung und Sport bei verschiedenen psychischen Erkrankungen belegt werden. Ein sportpsychiatrisches Basiswissen sollten alle in Psychiatrie und Psychotherapie klinisch Tätigen besitzen.
In recent years, all over the globe we have seen intensifying economic exploitation, political disenfranchisement, social marginalization and cultural repression in all kinds of political regimes, from liberal democratic to authoritarian and dictatorial. Although the strategies vary with regard to regime and context, in all of them we observe that while a growing number of social groups are speaking out and rising against them, a presumably much higher number of groups do not. In this article, I argue that all these processes can be conceived as aspects of ongoing closure struggles in social life. However, in order to understand why some social groups are able to fight against closure strategies while others are not, closure theory in its current state of elaboration is not of any help. While it operates with the term solidarization, it does not offer any explanation of how such acting in solidarity may become possible in closure struggles. The article is a mainly theoretical contribution of how to solve this problem.
Trying as hard as i can
(2022)
The housing crisis represents a liminal experience: a loss of the taken-for-granted and the suspension of ontological security has put individuals in a situation of potentiality in which both conceptions of home and of personal identity are open to transformation. Empirically assessing this liminal transition allows us to understand the refiguration processes of both home and subjectivities. This has both conceptual and political implications: with ongoing individualization of responsibility in virtually all spheres of social life, it is no longer possible to assume that the private sphere of home is an arena in which individuals are free and secured from societal forces, pressures, and compulsions. Instead, we might find ourselves in a transient liminal period in which the very meaning and psycho-social foundation of home are being transformed. To understand these processes is not only an epistemological but also a political endeavor, for only by understanding the psycho-social implications of the housing crisis can we acknowledge its embeddedness in and relation to processes of societal individualization, as well as the potential to open up pathways to the emergence of a liminal communitas.
Datenanalyse mit Stata
(2016)
Dieses Buch bietet eine Einführung in das Datenanalysepaket Stata und ist zugleich das einzige Buch über Stata, das auch Anfängern eine ausreichende Erklärung statistischer Verfahren liefert. „Datenanalyse mit Stata' ist kein Befehls-Handbuch sondern erläutert alle Schritte einer Datenanalyse an praktischen Beispielen. Die Beispiele beziehen sich auf Themen der öffentlichen Diskussion oder der direkten Umgebung der meisten Leser. Damit eignet sich diese Buch als Einstieg in Data Analytics in allen Disziplinen.
Die neue Auflage bietet einen systematischeren Zugang zum Datenmanagement in Gegenwart von „Missing Values' und behandelt die in der Stata-Programmversion 14 implementierte Unicode-Codierung.
Ulrich Päßler konnte im September 2019 den verschollen geglaubten Brief von Carl Friedrich Gauß an Alexander von Humboldt vom 17. August 1832 wiederfinden. Dieser Brief stammt aus der Anfangsphase von Gauß’ erdmagnetischen Forschungen. Gauß gibt an, sich erst vor einem halben Jahr in dieses Gebiet gewagt zu haben, das bislang Humboldt vorbehalten war. Die wichtigsten Themen des Briefes sind der Einfluss der Temperatur auf die magnetischen Eigenschaften sowie die Methoden der Magnetisierung von Nadeln und Stäben. Der Brief füllt eine wichtige Lücke in der Korrespondenz zwischen Gauß und Humboldt und ergänzt unsere Kenntnisse über bisher kaum wahrgenommene Forschungsfelder von Gauß. Es wird eine kritische kommentierte Edition des Briefes vorgestellt.
Wenn ein Bürgschaftsgläubiger vertragsschlussbezogene Aufklärungspflichten gegenüber dem Bürgen verletzt, kann der Bürge sich von der Bürgschaft lossagen, sei es durch Arglistanfechtung (§§ 123, 142 Abs. 1 BGB) oder im Wege des Naturalschadensersatzes aus culpa in contrahendo (§§ 311 Abs. 2, 241 Abs. 2, 280 Abs. 1, 249 Abs. 1 BGB). Inwieweit vertragsschlussbezogene Aufklärungspflichten des Bürgschaftsgläubigers bestehen, ist allerdings alles andere als klar. Es gibt hierzu interessante Rechtsprechung, aber oberhalb der Einzelfallebene sind die Begründungszusammenhänge dünn.
We consider rough metrics on smooth manifolds and corresponding Laplacians induced by such metrics. We demonstrate that globally continuous heat kernels exist and are Holder continuous locally in space and time. This is done via local parabolic Harnack estimates for weak solutions of operators in divergence form with bounded measurable coefficients in weighted Sobolev spaces.
Background: The role of fatty acid (FA) intake and metabolism in type 2 diabetes (T2D) incidence is controversial. Some FAs are not synthesised endogenously and, therefore, these circulating FAs reflect dietary intake, for example, the trans fatty acids (TFAs), saturated odd chain fatty acids (OCFAs), and linoleic acid, an n-6 polyunsaturated fatty acids (PUFA). It remains unclear if intake of TFA influence T2D risk and whether industrial TFAs (iTFAs) and ruminant TFAs (rTFAs) exert the same effect. Unlike even chain saturated FAs, the OCFAs have been inversely associated with T2D risk, but this association is poorly understood. Furthermore, the associations of n-6 PUFAs intake with T2D risk are still debated, while delta-5 desaturase (D5D), a key enzyme in the metabolism of PUFAs, has been consistently related to T2D risk. To better understand these relationships, the FA composition in circulating lipid fractions can be used as biomarkers of dietary intake and metabolism. The exploration of TFAs subtypes in plasma phospholipids and OCFAs and n-6 PUFAs within a wide range of lipid classes may give insights into the pathophysiology of T2D.
Aim: This thesis aimed mainly to analyse the association of TFAs, OCFAs and n-6 PUFAs with self-reported dietary intake and prospective T2D risk, using seven types of TFAs in plasma phospholipids and deep lipidomics profiling data from fifteen lipid classes.
Methods: A prospective case-cohort study was designed within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study, including all the participants who developed T2D (median follow-up 6.5 years) and a random subsample of the full cohort (subcohort: n=1248; T2D cases: n=820). The main analyses included two lipid profiles. The first was an assessment of seven TFA in plasma phospholipids, with a modified method for analysis of FA with very low abundances. The second lipid profile was derived from a high-throughout lipid profiling technology, which identified 940 distinct molecular species and allowed to quantify OCFAs and PUFAs composition across 15 lipid classes. Delta-5 desaturase (D5D) activity was estimated as 20:4/20:3-ratio. Using multivariable Cox regression models, we examined the associations of TFA subtypes with incident T2D and class-specific associations of OCFA and n-6 PUFAs with T2D risk.
Results: 16:1n-7t, 18:1n-7t, and c9t11-CLA were positively correlated with the intake of fat-rich dairy foods. iTFA 18:1 isomers were positively correlated with margarine. After adjustment for confounders and other TFAs, higher plasma phospholipid concentrations of two rTFAs were associated with a lower incidence of T2D: 18:1n-7t and t10c12-CLA. In contrast, the rTFA c9t11-CLA was associated with a higher incidence of T2D. rTFA 16:1n-7t and iTFAs (18:1n-6t, 18:1n-9t, 18:2n-6,9t) were not statistically significantly associated with T2D risk.
We observed heterogeneous integration of OCFA in different lipid classes, and the contribution of 15:0 versus 17:0 to the total OCFA abundance differed across lipid classes. Consumption of fat-rich dairy and fiber-rich foods were positively and red meat inversely correlated to OCFA abundance in plasma phospholipid classes. In women only, higher abundances of 15:0 in phosphatidylcholines (PC) and diacylglycerols (DG), and 17:0 in PC, lysophosphatidylcholines (LPC), and cholesterol esters (CE) were inversely associated with T2D risk. In men and women, a higher abundance of 15:0 in monoacylglycerols (MG) was also inversely associated with T2D. Conversely, a higher 15:0 concentration in LPC and triacylglycerols (TG) was associated with higher T2D risk in men. Women with a higher concentration of 17:0 as free fatty acids (FFA) also had higher T2D incidence.
The integration of n-6 PUFAs in lipid classes was also heterogeneous. 18:2 was highly abundant in phospholipids (particularly PC), CE, and TG; 20:3 represented a small fraction of FA in most lipid classes, and 20:4 accounted for a large proportion of circulating phosphatidylinositol (PI) and phosphatidylethanolamines (PE). Higher concentrations of 18:2 were inversely associated with T2D risk, especially within DG, TG, and LPC. However, 18:2 as part of MG was positively associated with T2D risk. Higher concentrations of 20:3 in phospholipids (PC, PE, PI), FFA, CE, and MG were linked to higher T2D incidence. 20:4 was unrelated to risk in most lipid classes, except positive associations were observed for 20:4 enriched in FFA and PE. The estimated D5D activities in PC, PE, PI, LPC, and CE were inversely associated with T2D and explained variance of estimated D5D activity by genomic variation in the FADS locus was only substantial in those lipid classes.
Conclusion: The TFAs' conformation is essential in their relationship to diabetes risk, as indicated by plasma rTFA subtypes concentrations having opposite directions of associations with diabetes risk. Plasma OCFA concentration is linked to T2D risk in a lipid class and sex-specific manner. Plasma n-6 PUFA concentrations are associated differently with T2D incidence depending on the specific FA and the lipid class. Overall, these results highlight the complexity of circulating FAs and their heterogeneous association with T2D risk depending on the specific FA structure, lipid class, and sex. My results extend the evidence of the relationship between diet, lipid metabolism, and subsequent T2D risk. In addition, my work generated several potential new biomarkers of dietary intake and prospective T2D risk.