- Intra-organ communication guides morphogenetic processes that are essential for an organ to carry out complex physiological functions. In the heart, the growth of the myocardium is tightly coupled to that of the endocardium, a specialized endothelial tissue that lines its interior. Several molecular pathways have been implicated in the communication between these tissues including secreted factors, components of the extracellular matrix, or proteins involved in cell-cell communication. Yet, it is unknown how the growth of the endocardium is coordinated with that of the myocardium. Here, we show that an increased expansion of the myocardial atrial chamber volume generates higher junctional forces within endocardial cells. This leads to biomechanical signaling involving VE-cadherin, triggering nuclear localization of the Hippo pathway transcriptional regulator Yap1 and endocardial proliferation. Our work suggests that the growth of the endocardium results from myocardial chamber volume expansion and ends when the tension on the tissueIntra-organ communication guides morphogenetic processes that are essential for an organ to carry out complex physiological functions. In the heart, the growth of the myocardium is tightly coupled to that of the endocardium, a specialized endothelial tissue that lines its interior. Several molecular pathways have been implicated in the communication between these tissues including secreted factors, components of the extracellular matrix, or proteins involved in cell-cell communication. Yet, it is unknown how the growth of the endocardium is coordinated with that of the myocardium. Here, we show that an increased expansion of the myocardial atrial chamber volume generates higher junctional forces within endocardial cells. This leads to biomechanical signaling involving VE-cadherin, triggering nuclear localization of the Hippo pathway transcriptional regulator Yap1 and endocardial proliferation. Our work suggests that the growth of the endocardium results from myocardial chamber volume expansion and ends when the tension on the tissue is relaxed.…
MetadatenVerfasserangaben: | Dorothee BornhorstORCiDGND, Peng XiaORCiDGND, Hiroyuki NakajimaORCiD, Chaitanya DingareORCiD, Wiebke HerzogORCiD, Virginie LecaudeyORCiDGND, Naoki MochizukiORCiD, Carl-Philipp HeisenbergORCiDGND, Deborah YelonORCiD, Salim Abdelilah-SeyfriedORCiDGND |
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DOI: | https://doi.org/10.1038/s41467-019-12068-x |
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ISSN: | 2041-1723 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/31511517 |
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Titel des übergeordneten Werks (Englisch): | Nature Communications |
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Verlag: | Nature Publ. Group |
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Verlagsort: | London |
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Publikationstyp: | Wissenschaftlicher Artikel |
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Sprache: | Englisch |
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Datum der Erstveröffentlichung: | 11.09.2019 |
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Erscheinungsjahr: | 2019 |
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Datum der Freischaltung: | 24.11.2020 |
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Band: | 10 |
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Seitenanzahl: | 10 |
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Fördernde Institution: | Excellence cluster REBIRTH; Deutsche Forschungsgemeinschaft (DFG)German Research Foundation (DFG) [SE2016/7-2, SE2016/10-1]; DZHK; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 HL069594, R01 HL108599]; Excellence cluster REBIRTH [SFB958] |
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Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
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DDC-Klassifikation: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
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Peer Review: | Referiert |
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Publikationsweg: | Open Access |
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| Open Access / Gold Open-Access |
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| DOAJ gelistet |
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