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Genetic divergence is impacted by many factors, including phylogenetic history, gene flow, genetic drift, and divergent selection. Rotifers are an important component of aquatic ecosystems, and genetic variation is essential to their ongoing adaptive diversification and local adaptation. In addition to coding sequence divergence, variation in gene expression may relate to variable heat tolerance, and can impose ecological barriers within species. Temperature plays a significant role in aquatic ecosystems by affecting species abundance, spatio-temporal distribution, and habitat colonization. Recently described (formerly cryptic) species of the Brachionus calyciflorus complex exhibit different temperature tolerance both in natural and in laboratory studies, and show that B. calyciflorus sensu stricto (s.s.) is a thermotolerant species. Even within B. calyciflorus s.s., there is a tendency for further temperature specializations. Comparison of expressed genes allows us to assess the impact of stressors on both expression and sequence divergence among disparate populations within a single species. Here, we have used RNA-seq to explore expressed genetic diversity in B. calyciflorus s.s. in two mitochondrial DNA lineages with different phylogenetic histories and differences in thermotolerance. We identify a suite of candidate genes that may underlie local adaptation, with a particular focus on the response to sustained high or low temperatures. We do not find adaptive divergence in established candidate genes for thermal adaptation. Rather, we detect divergent selection among our two lineages in genes related to metabolism (lipid metabolism, metabolism of xenobiotics).
Regulatory focus is a motivational construct that describes humans’ motivational orientation during goal pursuit. It is conceptualized as a chronic, trait-like, as well as a momentary, state-like orientation. Whereas there is a large number of measures to capture chronic regulatory focus, measures for its momentary assessment are only just emerging. This paper presents the development and validation of a measure of Momentary–Chronic Regulatory Focus. Our development incorporates the distinction between self-guide and reference-point definitions of regulatory focus. Ideals and ought striving are the promotion and prevention dimension in the self-guide system; gain and non-loss regulatory focus are the respective dimensions within the reference-point system. Three-survey-based studies test the structure, psychometric properties, and validity of the measure in its version to assess chronic regulatory focus (two samples of working participants, N = 389, N = 672; one student sample [time 1, N = 105; time 2, n = 91]). In two further studies, an experience sampling study with students (N = 84, k = 1649) and a daily-diary study with working individuals (N = 129, k = 1766), the measure was applied to assess momentary regulatory focus. Multilevel analyses test the momentary measure’s factorial structure, provide support for its sensitivity to capture within-person fluctuations, and provide evidence for concurrent construct validity.
The interactions between atmosphere and steep topography in the eastern south–central Andes result in complex relations with inhomogenous rainfall distributions. The atmospheric conditions leading to deep convection and extreme rainfall and their spatial patterns—both at the valley and mountain-belt scales—are not well understood. In this study, we aim to identify the dominant atmospheric conditions and their spatial variability by analyzing the convective available potential energy (CAPE) and dew-point temperature (Td). We explain the crucial effect of temperature on extreme rainfall generation along the steep climatic and topographic gradients in the NW Argentine Andes stretching from the low-elevation eastern foreland to the high-elevation central Andean Plateau in the west. Our analysis relies on version 2.0 of the ECMWF’s (European Centre for Medium-RangeWeather Forecasts) Re-Analysis (ERA-interim) data and TRMM (Tropical Rainfall Measuring Mission) data. We make the following key observations: First, we observe distinctive gradients along and across strike of the Andes in dew-point temperature and CAPE that both control rainfall distributions. Second, we identify a nonlinear correlation between rainfall and a combination of dew-point temperature and CAPE through a multivariable regression analysis. The correlation changes in space along the climatic and topographic gradients and helps to explain controlling factors for extreme-rainfall generation. Third, we observe more contribution (or higher importance) of Td in the tropical low-elevation foreland and intermediate-elevation areas as compared to the high-elevation central Andean Plateau for 90th percentile rainfall. In contrast, we observe a higher contribution of CAPE in the intermediate-elevation area between low and high elevation, especially in the transition zone between the tropical and subtropical areas for the 90th percentile rainfall. Fourth, we find that the parameters of the multivariable regression using CAPE and Td can explain rainfall with higher statistical significance for the 90th percentile compared to lower rainfall percentiles. Based on our results, the spatial pattern of rainfall-extreme events during the past ∼16 years can be described by a combination of dew-point temperature and CAPE in the south–central Andes.
As structural membrane components and signaling effector molecules sphingolipids influence a plethora of host cell functions, and by doing so also the replication of viruses. Investigating the effects of various inhibitors of sphingolipid metabolism in primary human peripheral blood lymphocytes (PBL) and the human B cell line BJAB we found that not only the sphingosine kinase (SphK) inhibitor SKI-II, but also the acid ceramidase inhibitor ceranib-2 efficiently inhibited measles virus (MV) replication. Virus uptake into the target cells was not grossly altered by the two inhibitors, while titers of newly synthesized MV were reduced by approximately 1 log (90%) in PBL and 70-80% in BJAB cells. Lipidomic analyses revealed that in PBL SKI-II led to increased ceramide levels, whereas in BJAB cells ceranib-2 increased ceramides. SKI-II treatment decreased sphingosine-1-phosphate (S1P) levels in PBL and BJAB cells. Furthermore, we found that MV infection of lymphocytes induced a transient (0.5-6 h) increase in S1P, which was prevented by SKI-II. Investigating the effect of the inhibitors on the metabolic (mTORC1) activity we found that ceranib-2 reduced the phosphorylation of p70 S6K in PBL, and that both inhibitors, ceranib-2 and SKI-II, reduced the phosphorylation of p70 S6K in BJAB cells. As mTORC1 activity is required for efficient MV replication, this effect of the inhibitors is one possible antiviral mechanism. In addition, reduced intracellular S1P levels affect a number of signaling pathways and functions including Hsp90 activity, which was reported to be required for MV replication. Accordingly, we found that pharmacological inhibition of Hsp90 with the inhibitor 17-AAG strongly impaired MV replication in primary PBL. Thus, our data suggest that treatment of lymphocytes with both, acid ceramidase and SphK inhibitors, impair MV replication by affecting a number of cellular activities including mTORC1 and Hsp90, which alter the metabolic state of the cells causing a hostile environment for the virus.
Undisclosed desires
(2019)
Following decades of quality management featuring in higher education settings, questions regarding its implementation, impact and outcomes remain. Indeed, leaving aside anecdotal case studies and value-laden documentaries of best practice, current research still knows very little about the implementation of quality management in teaching and learning within higher education institutions. Referring to data collected from German higher education institutions in which a quality management department or functional equivalent was present, this article theorises and provides evidence for the supposition that the implementation of quality management follows two implicit logics. Specifically, it tends either towards the logic of appropriateness or, contrastingly, towards the logic of consequentialism. This study’s results also suggest that quality managers’ socialisation is related to these logics and that it influences their views on quality management in teaching and learning.
We construct eta- and rho-invariants for Dirac operators, on the universal covering of a closed manifold, that are invariant under the projective action associated to a 2-cocycle of the fundamental group. We prove an Atiyah-Patodi-Singer index theorem in this setting, as well as its higher generalisation. Applications concern the classification of positive scalar curvature metrics on closed spin manifolds. We also investigate the properties of these twisted invariants for the signature operator and the relation to the higher invariants.
We analyze trends in compound flooding resulting from high coastal water levels (HCWLs) and peak river discharge over northwestern Europe during 1901-2014. Compound peak discharge associated with 37 stream gauges with at least 70 years of record availability near the North and Baltic Sea coasts is used. Compound flooding is assessed using a newly developed index, compound hazard ratio, that compares the severity of river flooding associated with HCWL with the at-site, T-year (a flood with 1/T chance of being exceeded in any given year) fluvial peak discharge. Our findings suggest a spatially coherent pattern in the dependence between HCWL and river peaks and in compound flood magnitudes and frequency. For higher return levels, we find upward trends in compound hazard ratio frequency at midlatitudes (gauges from 47 degrees N to 60 degrees N) and downward trends along the high latitude (>60 degrees N) regions of northwestern Europe. Plain Language Summary Compound floods in delta areas, that is, the co-occurrence of high coastal water levels (HCWLs) and high river discharge, are a particular challenge for disaster management. Such events are caused by two distinct mechanisms: (1) HCWLs may affect river flows and water levels by backwater effects or by reversing the seaward flow of rivers, particularly in regions with elevation less than 10 m in northwestern Europe. (2) The correlation between HCWL and river flow peaks may also stem from a common meteorological driver. Severe storm periods may be associated with high winds leading to storm surges, and at the same time with high precipitation followed by inland flooding. Understanding the historical trends in compound flooding, owing to changes in relative sea levels, in river flooding and in the dependence between these two drivers, is essential for projecting future changes and disaster management. The risk assessment frameworks are often limited to assessing flood risk from a single driver only. We present a new approach to assess compound flood severity resulting from extreme coastal water level and peak river discharge. We find upward trends in compound flooding for midlatitude regions and downward trends for high latitudes in northwestern Europe.