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Background: In probable Alzheimer’s disease (AD), different memory systems, executive functioning, visuospatial recognition, and language are impaired. Regarding the latter, only a few studies have investigated morphosyntactic production thus far.
Aims: This study, which is a follow-up on Fyndanis, V., Manouilidou, C., Koufou, E., Karampekios, S., and Tsapakis, E. M. (2013). Agrammatic patterns in Alzheimer's disease: Evidence from tense, agreement, and aspect. Aphasiology, 27, 178–200. doi:10.1080/02687038.2012.705814, investigates whether verb-related morphosyntactic production is (selectively) impaired in AD focusing on two highly inflected languages, Greek and Italian. The morphosyntactic phenomena explored are subject–verb Agreement, Tense/Time Reference, and Mood. Focusing on these phenomena allows us to investigate if recent hypotheses, originally developed in aphasia research, can also capture results related to AD. We tested the hypotheses discussed in Fyndanis, V., Manouilidou, C., Koufou, E., Karampekios, S., and Tsapakis, E. M. (2013). Agrammatic patterns in Alzheimer's disease: Evidence from tense, agreement, and aspect. Aphasiology, 27, 178–200. doi:10.1080/02687038.2012.705814, that is, the Interpretable Features’ Impairment Hypothesis (IFIH) (e.g., Fyndanis, V., Varlokosta, S., & Tsapkini, K. 2012. Agrammatic production: Interpretable features and selective impairment in verb inflection. Lingua, 122, 1134–1147. doi:10.1016/j.lingua.2012.05.004) and the PAst DIscourse LInking Hypothesis (PADILIH; Bastiaanse, R., Bamyaci, E., Hsu, C., Lee, J., Yarbay Duman, T., & Thompson, C. K. 2011. Time reference in agrammatic aphasia: A cross-linguistic study. Journal of Neurolinguistics, 24, 652–673. doi:10.1016/j.jneuroling.2011.07.001).
Methods & Procedures: Two sentence completion tasks testing the production of subject-verb Agreement, Tense/Time Reference, and Mood were administered to 16 Greek-speaking and 10 Italian-speaking individuals with mild-to-moderate AD, as well as to 16 Greek-speaking and 11 Italian-speaking neurologically intact individuals who were matched with the participants with AD on age and education. Mixed-effects models were fitted to the data.
Outcomes & Results: At the group level, both the Greek and Italian participants with AD performed worse than the controls. Both AD groups revealed selective patterns of morphosyntactic production (Greek: Agreement/Mood > Time Reference; Italian: Agreement > Time Reference > Mood). Past Reference and Future Reference did not dissociate in either of the two AD groups. Nevertheless, in all four participants with AD who showed dissociations, Past Reference was more impaired than Future Reference.
Conclusions: The results indicate that the production of verb-related morphosyntactic categories can be impaired in mild-to-moderate AD. The different patterns observed in the two languages are partly attributable to the different way these languages encode Mood. The group results (of both the Greek-and Italian-speaking participants with AD) do not lend support to the PADILIH, whereas only the results of the Italian AD group are fully consistent with the IFIH. However, the individual data are consistent with the PADILIH, and the IFIH is informed by the present data and modified accordingly so that it can capture cross-linguistic patterns of morphosyntactic impairment.
In connected speech, many words are produced with a pronunciation that differs from the canonical form. How the speech recognition system deals with this variation is a fundamental issue in the language processing literature. The present study examines the roles of variant type, variant frequency, and context in the processing of French words with a canonical (schwa variant, e.g. semaine “week”) and a non-canonical pronunciation (no-schwa variant, s’maine). It asks whether the processing of canonical pronunciations is faster than the processing of non-canonical ones. Results of three lexical decision experiments reveal that more frequent variants are recognised more quickly, and that there is no advantage for canonical forms once variant frequency is accounted for. Two of these experiments further failed to find evidence that the context in which the words are presented modulate the effect of variant type. These findings are discussed in the light of spoken word recognition models.
Manifolds with corners in the present investigation are non-smooth configurations - specific stratified spaces - with an incomplete metric such as cones, manifolds with edges, or corners of piecewise smooth domains in Euclidean space. We focus here on operators on such "corner manifolds" of singularity order <= 2, acting in weighted corner Sobolev spaces. The corresponding corner degenerate pseudo-differential operators are formulated via Mellin quantizations, and they also make sense on infinite singular cones.
Previous research informs us about facilitators of employees’ promotive voice. Yet little is known about what determines whether a specific idea for constructive change brought up by an employee will be approved or rejected by a supervisor. Drawing on interactionist theories of motivation and personality, we propose that a supervisor will be least likely to support an idea when it threatens the supervisor’s power motive, and when it is perceived to serve the employee’s own striving for power. The prosocial versus egoistic intentions attributed to the idea presenter are proposed to mediate the latter effect. We conducted three scenario-based studies in which supervisors evaluated fictitious ideas voiced by employees that – if implemented – would have power-related consequences for them as a supervisor. Results show that the higher a supervisors’ explicit power motive was, the less likely they were to support a power-threatening idea (Study 1, N = 60). Moreover, idea support was less likely when this idea was proposed by an employee that was described as high (rather than low) on power motivation (Study 2, N = 79); attributed prosocial intentions mediated this effect. Study 3 (N = 260) replicates these results.
Schomburgk’s Chook
(2018)
Focusing on the politics of museums, collections and the untold stories of the scientific ‘specimens’ that travelled between Germany and Australia, this article reconstructs the historical, interpersonal and geopolitical contexts that made it possible for the stuffed skin of an Australian malleefowl to become part of the collections of Berlin’s Museum für Naturkunde. The author enquires into the kinds of contexts that are habitually considered irrelevant when a specimen of natural history is treated as an object of taxonomic information only. In case of this particular specimen human and non-human history become entangled in ways that link the fate of this one small Australian bird to the German revolutionary generation of 1848, to Germany’s nineteenth-century colonial aspirations, to settler–Indigenous relations, to the cruel realities that underpinned the production of scientific knowledge in colonial Australia, and to a present-day interest in reconstructing Indigenous knowledges.
Recollecting bones
(2018)
This article critically engages with the different politics of memory involved in debates over the restitution of Indigenous Australian ancestral remains stolen by colonial actors in the nineteenth and early twentieth centuries and brought to Berlin in the name of science. The debates crystallise how deeply divided German scientific discourses still are over the question of whether the historical and moral obligations of colonial injustice should be accepted or whether researchers should continue to profess scientific ‘disinterest’. The debates also reveal an almost unanimous disavowal of Indigenous Australian knowledges and mnemonic conceptions across all camps. The bitter ironies of this disavowal become evident when Indigenous Australian quests for the remains of their ancestral dead lost in the limbo of German scientific collections are juxtaposed with white Australian (fictional) quests for the remains of Ludwig Leichhardt, lost in the Australian interior.
For Charles Goodwin, Chuck
(2018)
This appreciation will not be a testimonial to Chuck’s numerous publications and research achievements – I am sure that others will have a lot to say about those. Instead, I will say something about how I personally experienced and think of him, as a researcher personality, based on the limited time and the few occasions that we have had together.
BACKGROUND: Work capacity demands are a concept to describe which psychological capacities are required in a job. Assessing psychological work capacity demands is of specific importance when mental health problems at work endanger work ability. Exploring psychological work capacity demands is the basis for mental hazard analysis or rehabilitative action, e.g. in terms of work adjustment. OBJECTIVE: This is the first study investigating psychological work capacity demands in rehabilitation patients with and without mental disorders. METHODS: A structured interview on psychological work capacity demands (Mini-ICF-Work; Muschalla, 2015; Linden et al., 2015) was done with 166 rehabilitation patients of working age. All interviews were done by a state-licensed socio-medically trained psychotherapist. Inter-rater-reliability was assessed by determining agreement in independent co-rating in 65 interviews. For discriminant validity purposes, participants filled in the Short Questionnaire for Work Analysis (KFZA, Prumper et al., 1994). RESULTS: In different professional fields, different psychological work capacity demands were of importance. The Mini-ICF-Work capacity dimensions reflect different aspects than the KFZA. Patients with mental disorders were longer on sick leave and had worse work ability prognosis than patients without mental disorders, although both groups reported similar work capacity demands. CONCLUSIONS: Psychological work demands - which are highly relevant for work ability prognosis and work adjustment processes - can be explored and differentiated in terms of psychological capacity demands.
The article responds to four commentaries on the concept of semi-parliamentary government and its application to Australian bicameralism. It highlights four main points: (1) Our preferred typology is not more ‘normative’ than existing approaches, but applies the criterion of ‘direct election’ equally to executive and legislature; (2) While the evolution of semi-parliamentary government had contingent elements, it plausibly also reflects the ‘equilibrium’ nature of certain institutional configurations; (3) The idea that a pure parliamentary system with pure proportional representation has absolute normative priority over ‘instrumentalist’ concerns about cabinet stability, identifiability and responsibility is questionable; and (4) The reforms we discuss may be unlikely to occur in Australia, but deserve consideration by scholars and institutional reformers in other democratic systems.
The article analyses the type of bicameralism we find in Australia as a distinct executive-legislative system – a hybrid between parliamentary and presidential government – which we call ‘semi-parliamentary government’. We argue that this hybrid presents an important and underappreciated alternative to pure parliamentary government as well as presidential forms of the power-separation, and that it can achieve a certain balance between competing models or visions of democracy. We specify theoretically how the semi-parliamentary separation of powers contributes to the balancing of democratic visions and propose a conceptual framework for comparing democratic visions. We use this framework to locate the Australian Commonwealth, all Australian states and 22 advanced democratic nation-states on a two-dimensional empirical map of democratic patterns for the period from 1995 to 2015.
The CH2Cl2/MeOH (1:1) extract of the aerial parts of Tephrosia subtriflora afforded a new flavanonol, named subtriflavanonol (1), along with the known flavanone spinoflavanone B, and the known flavanonols MS-II (2) and mundulinol. The structures were elucidated by the use of NMR spectroscopy and mass spectrometry. The absolute configuration of the flavanonols was determined based on quantum chemical ECD calculations. In the antiplasmodial assay, compound 2 showed the highest activity against chloroquine-sensitive Plasmodiumfalciparum reference clones (D6 and 3D7), artemisinin-sensitive isolate (F32-TEM) as well as field isolate (KSM 009) with IC50 values 1.4-4.6M without significant cytotoxicity against Vero and HEp2 cell lines (IC50>100M). The new compound (1) showed weak antiplasmodial activity, IC50 12.5-24.2M, but also showed selective anticancer activity against HEp2 cell line (CC50 16.9M). [GRAPHICS] .
Sensitivity to salience
(2018)
Sentence comprehension is optimised by indicating entities as salient through linguistic (i.e., information-structural) or visual means. We compare how salience of a depicted referent due to a linguistic (i.e., topic status) or visual cue (i.e., a virtual person's gaze shift) modulates sentence comprehension in German. We investigated processing of sentences with varying word order and pronoun resolution by means of self-paced reading and an antecedent choice task, respectively. Our results show that linguistic as well as visual salience cues immediately speeded up reading times of sentences mentioning the salient referent first. In contrast, for pronoun resolution, linguistic and visual cues modulated antecedent choice preferences less congruently. In sum, our findings speak in favour of a significant impact of linguistic and visual salience cues on sentence comprehension, substantiating that salient information delivered via language as well as the visual environment is integrated in the current mental representation of the discourse.
Although the detection of metastases radically changes prognosis of and treatment decisions for a cancer patient, clinically undetectable micrometastases hamper a consistent classification into localized or metastatic disease. This chapter discusses mathematical modeling efforts that could help to estimate the metastatic risk in such a situation. We focus on two approaches: (1) a stochastic framework describing metastatic emission events at random times, formalized via Poisson processes, and (2) a deterministic framework describing the micrometastatic state through a size-structured density function in a partial differential equation model. Three aspects are addressed in this chapter. First, a motivation for the Poisson process framework is presented and modeling hypotheses and mechanisms are introduced. Second, we extend the Poisson model to account for secondary metastatic emission. Third, we highlight an inherent crosslink between the stochastic and deterministic frameworks and discuss its implications. For increased accessibility the chapter is split into an informal presentation of the results using a minimum of mathematical formalism and a rigorous mathematical treatment for more theoretically interested readers.
The classification of vulnerabilities is a fundamental step to derive formal attributes that allow a deeper analysis. Therefore, it is required that this classification has to be performed timely and accurate. Since the current situation demands a manual interaction in the classification process, the timely processing becomes a serious issue. Thus, we propose an automated alternative to the manual classification, because the amount of identified vulnerabilities per day cannot be processed manually anymore. We implemented two different approaches that are able to automatically classify vulnerabilities based on the vulnerability description. We evaluated our approaches, which use Neural Networks and the Naive Bayes methods respectively, on the base of publicly known vulnerabilities.
Preface
(2018)
This book aims at understanding the diversity of planetary and lunar magnetic fields and their interaction with the solar wind. A synergistic interdisciplinary approach combines newly developed tools for data acquisition and analysis, computer simulations of planetary interiors and dynamos, models of solar wind interaction, measurement of terrestrial rocks and meteorites, and laboratory investigations. The following chapters represent a selection of some of the scientific findings derived by the 22 projects within the DFG Priority Program Planetary Magnetism" (PlanetMag). This introductory chapter gives an overview of the individual following chapters, highlighting their role in the overall goals of the PlanetMag framework. The diversity of the different contributions reflects the wide range of magnetic phenomena in our solar system. From the program we have excluded magnetism of the sun, which is an independent broad research discipline, but include the interaction of the solar wind with planets and moons. Within the subsequent 13 chapters of this book, the authors review the field centered on their research topic within PlanetMag. Here we shortly introduce the content of all the subsequent chapters and outline the context in which they should be seen.
Sub-municipal units (SMUs) in Germany differ in German Länder. In Berlin, Hamburg and München Metropole Districts fulfill a number of quasi-municipal self-government rights and functions. They have their own budget and strong councils, as well as mayors. In all other Länder, most sub-municipal councils were subordinated under the municipal council and directly elected mayor heading the administration. SMUs were introduced as a kind of compensation with different territorial reforms in the 1970s. Although directly elected, sub-municipal councilors are weak, and their advisory role competes with other newly established advisory boards. Here the focus remains on traffic and town planning. Some sub-municipal councils fulfill smaller administrative functions and become more relevant and important in recent decentralization strategies of neighborhood development.
Foreword
(2018)
In Europe, different countries developed a rich variety of sub-municipal institutions. Out of the plethora of intra- and sub-municipal decentralization forms (reaching from local outposts of city administration to “quasi-federal” structures), this book focuses on territorial sub-municipal units (SMUs) which combine multipurpose territorial responsibility with democratic legitimacy and can be seen as institutions promoting the articulation and realization of collective choices at a sub-municipal level.
Country chapters follow a common pattern that is facilitating systematic comparisons, while at the same time leaving enough space for national peculiarities and priorities chosen and highlighted by the authors, who also take advantage of the eventually existing empirical surveys and case studies.
Scenarios have become a key tool for supporting sustainability research on regional and global change. In this study we evaluate four regional scenario assessments: first, to explore a number of research challenges related to sustainability science and, second, to contribute to sustainability research in the specific case studies. The four case studies used commonly applied scenario approaches that are (i) a story and simulation approach with stakeholder participation in the Oum Zessar watershed, Tunisia, (ii) a participatory scenario exploration in the Rwenzori region, Uganda, (iii) a model-based prepolicy study in the Inner Niger Delta, Mali, and (iv) a model coupling-based scenario analysis in upper Thukela basin, South Africa. The scenario assessments are evaluated against a set of known challenges in sustainability science, with each challenge represented by two indicators, complemented by a survey carried out on the perception of the scenario assessments within the case study regions. The results show that all types of scenario assessments address many sustainability challenges, but that the more complex ones based on story and simulation and model coupling are the most comprehensive. The study highlights the need to investigate abrupt system changes as well as governmental and political factors as important sources of uncertainty. For an in-depth analysis of these issues, the use of qualitative approaches and an active engagement of local stakeholders are suggested. Studying ecological thresholds for the regional scale is recommended to support research on regional sustainability. The evaluation of the scenario processes and outcomes by local researchers indicates the most transparent scenario assessments as the most useful. Focused, straightforward, yet iterative scenario assessments can be very relevant by contributing information to selected sustainability problems.
This paper investigates the transferability of calibrated HBV model parameters under stable and contrasting conditions in terms of flood seasonality and flood generating processes (FGP) in five Norwegian catchments with mixed snowmelt/rainfall regimes. We apply a series of generalized (differential) split-sample tests using a 6-year moving window over (i) the entire runoff observation periods, and (ii) two subsets of runoff observations distinguished by the seasonal occurrence of annual maximum floods during either spring or autumn. The results indicate a general model performance loss due to the transfer of calibrated parameters to independent validation periods of -5 to -17%, on average. However, there is no indication that contrasting flood seasonality exacerbates performance losses, which contradicts the assumption that optimized parameter sets for snowmelt-dominated floods (during spring) perform particularly poorly on validation periods with rainfall-dominated floods (during autumn) and vice versa.
The newly collected Potsdam Grievance Statistics File (PGSF) holds data on the number and topics of grievances (Eingaben) that were addressed to local authorities of the German Democratic Republic (GDR) in the years 1970 to 1989. The PGSF allows quantitative analyses on topics such as participation, quality of life, and value change in the German Democratic Republic. This paper introduces the concepts of the data set and discusses the validity of its contents.
Hot localised charge carriers on the Si(111)-7x7 surface are modelled by small charged clusters. Such resonances induce non-local desorption, i.e. more than 10 nm away from the injection site, of chlorobenzene in scanning tunnelling microscope experiments. We used such a cluster model to characterise resonance localisation and vibrational activation for positive and negative resonances recently. In this work, we investigate to which extent the model depends on details of the used cluster or quantum chemistry methods and try to identify the smallest possible cluster suitable for a description of the neutral surface and the ion resonances. Furthermore, a detailed analysis for different chemisorption orientations is performed. While some properties, as estimates of the resonance energy or absolute values for atomic changes, show such a dependency, the main findings are very robust with respect to changes in the model and/or the chemisorption geometry. [GRAPHICS] .
Business process simulation is an important means for quantitative analysis of a business process and to compare different process alternatives. With the Business Process Model and Notation (BPMN) being the state-of-the-art language for the graphical representation of business processes, many existing process simulators support already the simulation of BPMN diagrams. However, they do not provide well-defined interfaces to integrate new concepts in the simulation environment. In this work, we present the design and architecture of a proof-of-concept implementation of an open and extensible BPMN process simulator. It also supports the simulation of multiple BPMN processes at a time and relies on the building blocks of the well-founded discrete event simulation. The extensibility is assured by a plug-in concept. Its feasibility is demonstrated by extensions supporting new BPMN concepts, such as the simulation of business rule activities referencing decision models and batch activities.
In university teaching today, it is common practice to record regular lectures and special events such as conferences and speeches. With these recordings, a large fundus of video teaching material can be created quickly and easily. Typically, lectures have a length of about one and a half hours and usually take place once or twice a week based on the credit hours. Depending on the number of lectures and other events recorded, the number of recordings available is increasing rapidly, which means that an appropriate form of provisioning is essential for the students. This is usually done in the form of lecture video platforms. In this work, we have investigated how lecture video platforms and the contained knowledge can be improved and accessed more easily by an increasing number of students. We came up with a multistep process we have applied to our own lecture video web portal that can be applied to other solutions as well.
Embedded smart home — remote lab MOOC with optional real hardware experience for over 4000 students
(2018)
MOOCs (Massive Open Online Courses) become more and more popular for learners of all ages to study further or to learn new subjects of interest. The purpose of this paper is to introduce a different MOOC course style. Typically, video content is shown teaching the student new information. After watching a video, self-test questions can be answered. Finally, the student answers weekly exams and final exams like the self test questions. Out of the points that have been scored for weekly and final exams a certificate can be issued. Our approach extends the possibility to receive points for the final score with practical programming exercises on real hardware. It allows the student to do embedded programming by communicating over GPIO pins to control LEDs and measure sensor values. Additionally, they can visualize values on an embedded display using web technologies, which are an essential part of embedded and smart home devices to communicate with common APIs. Students have the opportunity to solve all tasks within the online remote lab and at home on the same kind of hardware. The evaluation of this MOOCs indicates the interesting design for students to learn an engineering technique with new technology approaches in an appropriate, modern, supporting and motivating way of teaching.
When students watch learning videos online, they usually need to watch several hours of video content. In the end, not every minute of a video is relevant for the exam. Additionally, students need to add notes to clarify issues of a lecture. There are several possibilities to enhance the metadata of a video, e.g. a typical way to add user-specific information to an online video is a comment functionality, which allows users to share their thoughts and questions with the public. In contrast to common video material which can be found online, lecture videos are used for exam preparation. Due to this difference, the idea comes up to annotate lecture videos with markers and personal notes for a better understanding of the taught content. Especially, students learning for an exam use their notes to refresh their memories. To ease this learning method with lecture videos, we introduce the annotation feature in our video lecture archive. This functionality supports the students with keeping track of their thoughts by providing an intuitive interface to easily add, modify or remove their ideas. This annotation function is integrated in the video player. Hence, scrolling to a separate annotation area on the website is not necessary. Furthermore, the annotated notes can be exported together with the slide content to a PDF file, which can then be printed easily. Lecture video annotations support and motivate students to learn and watch videos from an E-Learning video archive.
An efficient Design Space Exploration (DSE) is imperative for the design of modern, highly complex embedded systems in order to steer the development towards optimal design points. The early evaluation of design decisions at system-level abstraction layer helps to find promising regions for subsequent development steps in lower abstraction levels by diminishing the complexity of the search problem. In recent works, symbolic techniques, especially Answer Set Programming (ASP) modulo Theories (ASPmT), have been shown to find feasible solutions of highly complex system-level synthesis problems with non-linear constraints very efficiently. In this paper, we present a novel approach to a holistic system-level DSE based on ASPmT. To this end, we include additional background theories that concurrently guarantee compliance with hard constraints and perform the simultaneous optimization of several design objectives. We implement and compare our approach with a state-of-the-art preference handling framework for ASP. Experimental results indicate that our proposed method produces better solutions with respect to both diversity and convergence to the true Pareto front.
Operational decisions in business processes can be modeled by using the Decision Model and Notation (DMN). The complementary use of DMN for decision modeling and of the Business Process Model and Notation (BPMN) for process design realizes the separation of concerns principle. For supporting separation of concerns during the design phase, it is crucial to understand which aspects of decision-making enclosed in a process model should be captured by a dedicated decision model. Whereas existing work focuses on the extraction of decision models from process control flow, the connection of process-related data and decision models is still unexplored. In this paper, we investigate how process-related data used for making decisions can be represented in process models and we distinguish a set of BPMN patterns capturing such information. Then, we provide a formal mapping of the identified BPMN patterns to corresponding DMN models and apply our approach to a real-world healthcare process.
Leaf senescence is an essential developmental process that involves diverse metabolic changes associated with degradation of macromolecules allowing nutrient recycling and remobilization. In contrast to the significant progress in transcriptomic analysis of leaf senescence, metabolomics analyses have been relatively limited. A broad overview of metabolic changes during leaf senescence including the interactions between various metabolic pathways is required to gain a better understanding of the leaf senescence allowing to link transcriptomics with metabolomics and physiology. In this chapter, we describe how to obtain comprehensive metabolite profiles and how to dissect metabolic shifts during leaf senescence in the model plant Arabidopsis thaliana. Unlike nucleic acid analysis for transcriptomics, a comprehensive metabolite profile can only be achieved by combining a suite of analytic tools. Here, information is provided for measurements of the contents of chlorophyll, soluble proteins, and starch by spectrophotometric methods, ions by ion chromatography, thiols and amino acids by HPLC, primary metabolites by GC/TOF-MS, and secondary metabolites and lipophilic metabolites by LC/ESI-MS. These metabolite profiles provide a rich catalogue of metabolic changes during leaf senescence, which is a helpful database and blueprint to be correlated to future studies such as transcriptome and proteome analyses, forward and reverse genetic studies, or stress-induced senescence studies.
The ensemble Kalman filter has become a popular data assimilation technique in the geosciences. However, little is known theoretically about its long term stability and accuracy. In this paper, we investigate the behavior of an ensemble Kalman-Bucy filter applied to continuous-time filtering problems. We derive mean field limiting equations as the ensemble size goes to infinity as well as uniform-in-time accuracy and stability results for finite ensemble sizes. The later results require that the process is fully observed and that the measurement noise is small. We also demonstrate that our ensemble Kalman-Bucy filter is consistent with the classic Kalman-Bucy filter for linear systems and Gaussian processes. We finally verify our theoretical findings for the Lorenz-63 system.
Design thinking is acknowledged as a thriving innovation practice plus something more, something in the line of a deep understanding of innovation processes. At the same time, quite how and why design thinking works-in scientific terms-appeared an open question at first. Over recent years, empirical research has achieved great progress in illuminating the principles that make design thinking successful. Lately, the community began to explore an additional approach. Rather than setting up novel studies, investigations into the history of design thinking hold the promise of adding systematically to our comprehension of basic principles. This chapter makes a start in revisiting design thinking history with the aim of explicating scientific understandings that inform design thinking practices today. It offers a summary of creative thinking theories that were brought to Stanford Engineering in the 1950s by John E. Arnold.
We applied coarse spectral analysis to more than 2 decades of daily near-surface water temperature (WT) measurements from Muggelsee, a shallow polymictic lake in Germany, to systematically characterize patterns in WT variability from daily to yearly temporal scales. Comparison of WT with local air temperature indicates that the WT variability patterns are likely attributable to both meteorological forcing and internal lake dynamics. We identified seasonal patterns of WT variability and showed that WT variability increases with increasing Schmidt stability, decreasing Lake number and decreasing ice cover duration, and is higher near the shore than in open water. We introduced the slope of WT spectra as an indicator for the degree of lake mixing to help explain the identified temporal and spatial scales of WT variability. The explanatory power of this indicator in other lakes with different mixing regimes remains to be established.
The endothelialization of synthetic surfaces applied as cardiovascular implant materials is an important issue to ensure the anti-thrombotic quality of a biomaterial. However, the rapid and constant development of a functionallycon-fluent endothelial cell monolayer is challenging. In order to investigate the compatibility of potential implant materials with endothelial cells several in vitro studies are performed. Here, glass and tissue culture plates (TCP) are often used as reference materials for in vitro pre-testing. However, a direct comparison of both substrates is lacking. Therefore, a comparison of study results is difficult, since results are often related to various reference materials. In this study, the endothelialization of glass and TCP was investigated in terms of adherence, morphology, integrity, viability and function using human umbilical vein endothelial cells (HUVEC). On both substrates an almost functionally confluent HUVEC monolayer was developed after nine days of cell seeding with clearly visible cell rims, decreased stress fiber formation and a pronounced marginal filament band. The viability of HUVEC was comparable for both substrates nine days after cell seeding with only a few dead cells. According to that, the cell membrane integrity as well as the metabolic activity showed no differences between TCP and glass. However, a significant difference was observed for the secretion of IL-6 and IL-8. The concentration of both cytokines, which are associated with migratory activity, was increased in the supernatant of HUVEC seeded on TCP. This result matches well with the slightly increased number of adherent HUVEC on TCP. In conclusion, these findings indicate that both reference materials are almost comparable and can be used equivalently as control materials in in vitro endothelialization studies.
BACKGROUND: Physical and chemical characteristics of implant materials determine the fate of long-term cardiovascular devices. However, there is still a lack of fundamental understanding of the molecular mechanisms occurring in the material-tissue interphase. In a previous study, soft covalently crosslinked poly(n-butyl acrylate) networks (cPnBA) were introduced as sterilizable, non-toxic and immuno-compatible biomaterials with mechanical properties adjustable to blood vessels. Here we study the influence of different surface treatments in particular oxygen plasma modification and fibrinogen deposition as well as a combinatorial approach on the adhesion and viability of fibroblasts. RESULTS: Compared to non-treated cPnBAs the advancing water-contact angles were found to be reduced after all surface modifications (p<0.05, each), while lowest values were observed after the combined surface treatment (OPT+FIB). The latter differed significantly from the single OPT and FIB. The number of adherent fibroblasts and their adherence behavior differed on both pristine cPnBA networks. The fibroblast density on cPnBA04 was 743 +/- 434 cells. mm(-2), was about 6.5 times higher than on cPnBA73 with 115 +/- 73 cells. mm(-2). On cPnBA04 about 20% of the cells were visible as very small, round and buckled cells while all other cells were in a migrating status. On cPnBA73, nearly 50% of fibroblasts were visible as very small, round and buckled cells. The surface functionalization either using oxygen plasma treatment or fibrinogen coating led to a significant increase of adherent fibroblasts, particularly the combination of both techniques, for both cPnBA networks. It is noteworthy to mention that the fibrinogen coating overruled the characteristics of the pristine surfaces; here, the fibroblast densities after seeding were identical for both cPnBAnetworks. Thus, the binding rather depended on the fibrinogen coating than on the substrate characteristics anymore. While the integrity of the fibroblasts membrane was comparable for both polymers, the MTS tests showed a decreased metabolic activity of the fibroblasts on cPnBA. CONCLUSION: The applied surface treatments of cPnBA successfully improved the adhesion of viable fibroblasts. Under resting conditions as well as after shearing the highest fibroblast densities were found on surfaces with combined post-treatment.
Remaining uremic toxins in the blood of chronic renal failure patients represent one central challenge in hemodialysis therapies. Highly porous poly(ether imide) (PEI) microparticles have been recently introduced as candidate absorber materials, which show a high absorption capacity for uremic toxins and allow hydrophilic surface modification suitable for minimization of serum protein absorption. In this work, the effects of extracts prepared from PEI microparticles modified by nucleophilic reaction with low molecular weight polyethylene imine (Pei) or potassium hydroxide (KOH), on human monocytic (THP-1) cells are studied. The obtained results suggested that the extracts of Pei and KOH modified PEI absorbers have no negative effect on THP-1 cell viability and do not initiate the critical differentiation towards macrophages. The extracts did not enhance transcript or protein levels of investigated proinflammatory markers in THP-1 cells, namely, TNF alpha, MCP1, IL6 and IL8. Based on these findings such modified PEI microparticles should be qualified for further pre-clinical evaluation i.e. in an in vivo animal experiment.
We study the Ollivier-Ricci curvature of graphs as a function of the chosen idleness. We show that this idleness function is concave and piecewise linear with at most three linear parts, and at most two linear parts in the case of a regular graph. We then apply our result to show that the idleness function of the Cartesian product of two regular graphs is completely determined by the idleness functions of the factors.
Based on new Chandra X-ray telescope data, we present empirical evidence of plasma Compton cooling during a flare in the non-pulsating massive X-ray binary 4U1700-37. This behaviour might be explained by quasi-spherical accretion on to a slowly rotating magnetized neutron star (NS). In quiescence, the NS in 4U1700-37 is surrounded by a hot radiatively cooling shell. Its presence is supported by the detection of mHz quasi-periodic oscillations likely produced by its convection cells. The high plasma temperature and the relatively low X-ray luminosity observed during the quiescence, point to a small emitting area similar to 1 km, compatible with a hotspot on an NS surface. The sudden transition from a radiative to a significantly more efficient Compton cooling regime triggers an episode of enhanced accretion resulting in a flare. During the flare, the plasma temperature drops quickly. The predicted luminosity for such transitions, similar to 3 x 10(35) erg s(-1), is very close to the luminosity of 4U1700-37 during quiescence. The transition may be caused by the accretion of a clump in the stellar wind of the donor star. Thus, a magnetized NS nature of the compact object is strongly favoured.
Is there an ideal time window for language acquisition after which nativelike representation and processing are unattainable? Although this question has been heavily debated, no consensus has been reached. Here, we present evidence for a sensitive period in language development and show that it is specific to grammar. We conducted a masked priming task with a group of Turkish-German bilinguals and examined age of acquisition (AoA) effects on the processing of complex words. We compared a subtle but meaningful linguistic contrast, that between grammatical inflection and lexical-based derivation. The results showed a highly selective AoA effect on inflectional (but not derivational) priming. In addition, the effect displayed a discontinuity indicative of a sensitive period: Priming from inflected forms was nativelike when acquisition started before the age of 5 but declined with increasing AoA. We conclude that the acquisition of morphological rules expressing morphosyntactic properties is constrained by maturational factors.
This essay sets out to theorize the "new" Arctic Ocean as a pivot from which our standard map of the world is currently being reconceptualized. Drawing on theories from the fields of Atlantic and Pacific studies, I argue that the changing Arctic, characterized by melting ice and increased accessibility, must be understood both as a space of transit that connects Atlantic and Pacific worlds in unprecedented ways, and as an oceanic world and contact zone in its own right. I examine both functions of the Arctic via a reading of the dispute over the Northwest Passage (which emphasizes the Arctic as a space of transit) and the contemporary assessment of new models of sovereignty in the Arctic region (which concentrates on the circumpolar Arctic as an oceanic world). However, both of these debates frequently exclude indigenous positions on the Arctic. By reading Canadian Inuit theories on the Arctic alongside the more prominent debates, I argue for a decolonizing reading of the Arctic inspired by Inuit articulations of the "Inuit Sea." In such a reading, Inuit conceptions provide crucial interventions into theorizing the Arctic. They also, in turn, contribute to discussions on indigeneity, sovereignty, and archipelagic theory in Atlantic and Pacific studies.
Background/Aims: Angiogenesis plays a key role during embryonic development. The vascular endothelin (ET) system is involved in the regulation of angiogenesis. Lipopolysaccharides (LPS) could induce angiogenesis. The effects of ET blockers on baseline and LPS-stimulated angiogenesis during embryonic development remain unknown so far. Methods: The blood vessel density (BVD) of chorioallantoic membranes (CAMs), which were treated with saline (control), LPS, and/or BQ123 and the ETB blocker BQ788, were quantified and analyzed using an IPP 6.0 image analysis program. Moreover, the expressions of ET-1, ET-2, ET3, ET receptor A (ETRA), ET receptor B (ETRB) and VEGFR2 mRNA during embryogenesis were analyzed by semi-quantitative RT-PCR. Results: All components of the ET system are detectable during chicken embryogenesis. LPS increased angiogenesis substantially. This process was completely blocked by the treatment of a combination of the ETA receptor blockers-BQ123 and the ETB receptor blocker BQ788. This effect was accompanied by a decrease in ETRA, ETRB, and VEGFR2 gene expression. However, the baseline angiogenesis was not affected by combined ETA/ETB receptor blockade. Conclusion: During chicken embryogenesis, the LPS-stimulated angiogenesis, but not baseline angiogenesis, is sensitive to combined ETA/ETB receptor blockade.
Many educational technology proponents support the Technological Pedagogical Content Knowledge (TPACK) model as a way to conceptualize teaching with technology, but recent TPACK research shows a need for empirical studies regarding the development of this knowledge. This proof-of-concept study applies mixed-methods to investigate the meta-cognitive awareness produced by teachers who participate in the Graphic Assessment of TPACK Instrument (GATI). This process involves creating graphical representations (circles of differing sizes and the degree of their overlap) that represent what teachers understand to be their current and aspired TPACK. This study documented teachers’ explanations during a think-aloud procedure as they created their GATI figures. The in-depth data from two German teachers who participated in the process captured the details of their experience and demonstrated the potential of the GATI to support teachers in reflecting about their professional knowledge and in determining their own professional development activities. These findings will be informative to future pilot studies involving the larger design of the GATI process, to better understand the role of teachers’ meta-conceptual awareness, and to better ascertain how the GATI might be used to support professional development on a larger scale.
This paper analyses the interaction of domestic political elites and external donors against the backdrop of Mozambique’s decentralisation process. The empirical research at national and local levels supports the hypothesis that informal power structures influence the dynamics of this interaction. Consequently, this contributes to an outcome of externally induced democratisation different to what was intended by external actors. The decentralisation process has been utilised by ruling domestic elites for political purposes. Donors have rather focused on the technical side and ignored this informal dimension. By analysing the diverging objectives and perceptions of external and internal actors, as well as the instrumentalisation of formal democratic structures, it becomes clear, that the ‘informal has to be seen as normal’. At a theoretical level, the analysis contributes to elite-oriented approaches of post-conflict democratisation by adding ‘the informal’ as an additional factor for the dynamics of external-internal interaction. At a policy level, external actors need to take more into account informal power structures and their ambivalence for state-building and democratisation.
Involvement of disadvantaged individuals into entrepreneurship facilitates their social integration into mainstream societies. The present study addresses the drivers of social entrepreneurial appraisal among hearing-impaired individuals within a unique social minority environment. In prior research, social appraisal was empirically shown to determine social entrepreneurial intention. Adopting the theory of planned behaviour, this study investigates the impact of entrepreneurial self-efficacy, general social support and perceived barriers on social entrepreneurial appraisal. Based on a survey with 221 respondents, our results demonstrate that social entrepreneurial appraisal of hearing-impaired individuals result from their entrepreneurial self-efficacy and general social support. In terms of taking advantage of social opportunities, importance should be given to the role of entrepreneurial education and heterogeneous networks across minorities.
Background: The association between stature and social dominance is known. Dominance within social groups and current politics are related issues. We therefore aimed to compare estimates of the opinion of a population about their current political issues, with physical growth. Material and methods: We used data on the 2012 and the 2014 elections for the Japanese House of Representatives and the percent proportion of votes of the 47 prefectures of Japan, and regional data on body height of 17.5 year old men and women. Information on capita income, possession of mobile phones, urban/rural population ratio, and age distribution were added to capture socioeconomic factors. Four political parties were present in most of the 47 prefectures: the Liberal Democratic Party (LDP), the Democratic Party of Japan (DPJ), the New Komeito Party (Kom) that is known for their social network community, and the Japanese Communist Party (JCP). Results: A dense network of associations exists between height, age distribution, per capita income, number of smartphones, and voting results. Male and female body height was inversely related with the proportion of votes for New Komeito Party. Average stature decreases by one mm per percent votes for this political party. Medium strong positive associations were found for male body height and voting results of the DPJ and for female body height with the JCP election results. Conclusion: In modern Japan, popular preferences for conservative political structures coincide with shorter stature.
Introduction: Body height is influenced by biological factors such as genetics, nutrition and health, but also by the social network, and environmental and economical factors. During centuries, the Japanese society has developed on islands. This setting provides ideal natural conditions for studying the influence of social networks on human height. Material and methods: We investigated body height of male Japanese students aged 17.5 years obtained in 47 prefectures, from the Japanese school health survey of the years 1955, 1975, 1995, and 2015. Results: Japanese students increased in height from 163.23 cm in 1955 to 170.84 cm in 1995, with no further increase thereafter (170.63 cm in 2015). Students living in neighboring prefectures were similar in height. The correlation of height between neighboring prefectures ranged between r = 0.79 and r = 0.49 among first degree neighbors, between r = 0.49 and r = 0.21 among second degree neighbors and dropped to insignificance among third degree neighbors indicating psychosocial effects of the community on body height. Tall stature and short stature prefectures did not remain tall or short throughout history. Autocorrelations of height within the same prefectures decreased from the 20 years periods of 1955-1975, 1975-1995 and 1995-2015 (r = 0.52, r = 0.61, r = 0.63, respectively) to the 40 years periods of 1955-1995 and 1975-2015 (r = 0.49, r = 0.52), down to the 60 years period of 1955-2015 (r = 0.27), indicating significant volatility of height. Conclusion: Body height of 17.5 years old Japanese students increased since 1955. Body height depended on height of the neighboring prefecture, but was volatile with decreasing autocorrelation during a period of 60 years.