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Negative affect is related to reduced differential neural responses to social and non-social stimuli in 5-to-8-month-old infants (2018)

van der Kant, Anne ; Biro, Szilvia ; Levelt, Claartje ; Huijbregts, Stephan

Both social perception and temperament in young infants have been related to social functioning later in life. Previous functional Near-Infrared Spectroscopy (fNIRS) data (Lloyd-Fox et al., 2009) showed larger blood-oxygenation changes for social compared to non-social stimuli in the posterior temporal cortex of five-month-old infants. We sought to replicate and extend these findings by using fNIRS to study the neural basis of social perception in relation to infant temperament (Negative Affect) in 37 five-to-eight-month-old infants. Infants watched short videos displaying either hand and facial movements of female actors (social dynamic condition) or moving toys and machinery (non-social dynamic condition), while fNIRS data were collected over temporal brain regions. Negative Affect was measured using the Infant Behavior Questionnaire. Results showed significantly larger blood-oxygenation changes in the right posterior-temporal region in the social compared to the non-social condition. Furthermore, this differential activation was smaller in infants showing higher Negative Affect. Our results replicate those of Lloyd-Fox et al. and confirmed that five-to-eight-month-old infants show cortical specialization for social perception. Furthermore, the decreased cortical sensitivity to social stimuli in infants showing high Negative Affect may be an early biomarker for later difficulties in social interaction.

Regulation of the organokines FGF21 and chemerin by diet (2020)

Seebeck, Nicole

The hepatokine FGF21 and the adipokine chemerin have been implicated as metabolic regulators and mediators of inter-tissue crosstalk. While FGF21 is associated with beneficial metabolic effects and is currently being tested as an emerging therapeutic for obesity and diabetes, chemerin is linked to inflammation-mediated insulin resistance. However, dietary regulation of both organokines and their role in tissue interaction needs further investigation. The LEMBAS nutritional intervention study investigated the effects of two diets differing in their protein content in obese human subjects with non-alcoholic fatty liver disease (NAFLD). The study participants consumed hypocaloric diets containing either low (LP: 10 EN%, n = 10) or high (HP: 30 EN%, n = 9) dietary protein 3 weeks prior to bariatric surgery. Before and after the intervention the participants were anthropometrically assessed, blood samples were drawn, and hepatic fat content was determined by MRS. During bariatric surgery, paired subcutaneous and visceral adipose tissue biopsies as well as liver biopsies were collected. The aim of this thesis was to investigate circulating levels and tissue-specific regulation of (1) FGF21 and (2) chemerin in the LEMBAS cohort. The results were compared to data obtained in 92 metabolically healthy subjects with normal glucose tolerance and normal liver fat content. (1) Serum FGF21 concentrations were elevated in the obese subjects, and strongly associated with intrahepatic lipids (IHL). In accordance, FGF21 serum concentrations increased with severity of NAFLD as determined histologically in the liver biopsies. Though both diets were successful in reducing IHL, the effect was more pronounced in the HP group. FGF21 serum concentrations and mRNA expression were bi-directionally regulated by dietary protein, independent from metabolic improvements. In accordance, in the healthy study subjects, serum FGF21 concentrations dropped by more than 60% in response to the HP diet. A short-term HP intervention confirmed the acute downregulation of FGF21 within 24 hours. Lastly, experiments in HepG2 cell cultures and primary murine hepatocytes identified nitrogen metabolites (NH4Cl and glutamine) to dose-dependently suppress FGF21 expression. (2) Circulating chemerin concentrations were considerably elevated in the obese versus lean study participants and differently associated with markers of obesity and NAFLD in the two cohorts. The adipokine decreased in response to the hypocaloric interventions while an unhealthy high-fat diet induced a rise in chemerin serum levels. In the lean subjects, mRNA expression of RARRES2, encoding chemerin, was strongly and positively correlated with expression of several cytokines, including MCP1, TNFα, and IL6, as well as markers of macrophage infiltration in the subcutaneous fat depot. However, RARRES2 was not associated with any cytokine assessed in the obese subjects and the data indicated an involvement of chemerin not only in the onset but also resolution of inflammation. Analyses of the tissue biopsies and experiments in human primary adipocytes point towards a role of chemerin in adipogenesis while discrepancies between the in vivo and in vitro data were detected. Taken together, the results of this thesis demonstrate that circulating FGF21 and chemerin levels are considerably elevated in obesity and responsive to dietary interventions. FGF21 was acutely and bi-directionally regulated by dietary protein in a hepatocyte-autonomous manner. Given that both, a lack in essential amino acids and excessive nitrogen intake, exert metabolic stress, FGF21 may serve as an endocrine signal for dietary protein balance. Lastly, the data revealed that chemerin is derailed in obesity and associated with obesity-related inflammation. However, future studies on chemerin should consider functional and regulatory differences between secreted and tissue-specific isoforms.

Nervous allies (2018)

Grötzner, Björn

Diese Dissertation untersucht die Entwicklung der diplomatischen Beziehungen zwischen Frankreich, den USA und der Bundesrepublik Deutschland im Zeitraum von 1969-1980. Auf breiter multiarchivarischer Quellengrundlage rekonstruiert sie die interdependente Außenpolitik dieser drei Staaten im Kontext zentraler Themenkomplexe der 1970er Jahre: des Aufstiegs und Verfalls der Entspannungspolitik, des Streits um den Status quo in Europa, die Deutsche Frage und die Zukunft Berlins, der internationalen Wirtschafts- und Währungskrise, der Debatte um Sicherheit und Zukunft des westlichen Bündnisses und des NATO-Doppelbeschlusses. Ebenso betrachtet werden eine Reihe von regionalen Ereignissen und Konflikten mit weitreichenden Auswirkungen wie der Jom-Kippur-Krieg, die Portugiesische Revolution oder die sowjetische Invasion Afghanistans. Die Untersuchung folgt der zentralen, theoretisch motivierten Fragestellung, in welchem Maß staatliche Außenpolitik und diplomatische Beziehungen von individuellen Akteuren an der Spitze der Regierungen, ihren Agenden, Sichtweisen und persönlichen Beziehungen zu internationalen Partnern geprägt wurden oder in welchem Maß deren Entscheidungsfindung andererseits durch strukturelle Faktoren geopolitischer, ökonomischer oder politischer Natur definiert und limitiert wurde. Um diese Frage zu beantworten, fokussiert sich die Dissertation auf die Analyse von Regierungswechseln und deren Auswirkungen auf Kontinuität und Wandel der Außenpolitik. Die Narrative umfasst sieben solcher Regierungswechsel: von Bundeskanzler Kurt Georg Kiesinger zu Willy Brandt (1969) und von Brandt zu Helmut Schmidt (1974) in Bonn, von Präsident Charles de Gaulle zu Georges Pompidou (1969) und von Pompidou zu Valéry Giscard d’Estaing (1974) in Paris sowie von Lyndon B. Johnson zu Richard M. Nixon (1969), von Nixon zu Gerald R. Ford (1974) und von Ford zu Jimmy Carter (1977) in Washington. Abseits eines Spektrums empirisch fundierter Erkenntnisse über die Geschichte der internationalen Beziehungen der 1970er Jahre belegt diese Arbeit vor allem hochgradig personalisierte und exklusive außenpolitische Entscheidungsstrukturen und eine deutliche Abhängigkeit der Qualität intergouvernementaler Beziehungen von den persönlichen Beziehungen außenpolitischer Führungspersönlichkeiten. Zugleich werden jedoch strukturelle Grenzen ihres Handlungsspielraums im internationalen System deutlich, die von Faktoren wie militärischer Sicherheit und geopolitischer Lage, Zugang zu Ressourcen und ökonomischer Leistungsfähigkeit sowie politischem Druck aus dem In- und Ausland abhängen. Die Dissertation kommt zu dem zentralen Ergebnis, dass Regierungswechsel zwar bisweilen drastische Einschnitte in Inhalt und Stil der auswärtigen Beziehungen nach sich zogen und Bonn, Paris und Washington im Laufe der Dekade mit vielerlei neuen Herausforderungen konfrontiert wurden, dass in der Gesamtschau jedoch pfadabhängige strukturelle Druckszenarien zu höherer politischer Kontinuität im internationalen System führten, als oft mit den für tiefgreifenden historischen Wandel bekannten 1970er Jahren assoziiert wird.

p53 as a dichotomous regulator of liver disease (2018)

Krstic, Jelena ; Galhuber, Markus ; Schulz, Tim J. ; Schupp, Michael ; Prokesch, Andreas

Lifestyle-related disorders, such as the metabolic syndrome, have become a primary risk factor for the development of liver pathologies that can progress from hepatic steatosis, hepatic insulin resistance, steatohepatitis, fibrosis and cirrhosis, to the most severe condition of hepatocellular carcinoma (HCC). While the prevalence of liver pathologies is steadily increasing in modern societies, there are currently no approved drugs other than chemotherapeutic intervention in late stage HCC. Hence, there is a pressing need to identify and investigate causative molecular pathways that can yield new therapeutic avenues. The transcription factor p53 is well established as a tumor suppressor and has recently been described as a central metabolic player both in physiological and pathological settings. Given that liver is a dynamic tissue with direct exposition to ingested nutrients, hepatic p53, by integrating cellular stress response, metabolism and cell cycle regulation, has emerged as an important regulator of liver homeostasis and dysfunction. The underlying evidence is reviewed herein, with a focus on clinical data and animal studies that highlight a direct influence of p53 activity on different stages of liver diseases. Based on current literature showing that activation of p53 signaling can either attenuate or fuel liver disease, we herein discuss the hypothesis that, while hyper-activation or loss of function can cause disease, moderate induction of hepatic p53 within physiological margins could be beneficial in the prevention and treatment of liver pathologies. Hence, stimuli that lead to a moderate and temporary p53 activation could present new therapeutic approaches through several entry points in the cascade from hepatic steatosis to HCC.

Extreme HBL behavior of Markarian 501 during 2012 (2018)

Ahnen, M. L. ; Ansoldi, S. ; Antonelli, L. A. ; Arcaro, C. ; Babic, A. ; Banerjee, B. ; Bangale, P. ; Barres de Almeida, U. ; Barrio, J. A. ; Gonzalez, J. Becerra ; Bednarek, W. ; Bernardini, E. ; Berti, A. ; Bhattacharyya, W. ; Blanch, O. ; Bonnoli, G. ; Carosi, R. ; Carosi, A. ; Chatterjee, A. ; Colak, S. M. ; Colin, P. ; Colombo, E. ; Contreras, J. L. ; Cortina, J. ; Covino, S. ; Cumani, P. ; Da Vela, P. ; Dazzi, F. ; De Angelis, A. ; De Lotto, B. ; Delfino, M. ; Delgado, J. ; Di Pierro, F. ; Doert, M. ; Dominguez, A. ; Prester, D. Dominis ; Doro, M. ; Glawion, D. Eisenacher ; Engelkemeier, M. ; Ramazani, V. Fallah ; Fernandez-Barral, A. ; Fidalgo, D. ; Fonseca, M. V. ; Font, L. ; Fruck, C. ; Galindo, D. ; Lopez, R. J. Garcia ; Garczarczyk, M. ; Gaug, M. ; Giammaria, P. ; Godinovic, N. ; Gora, D. ; Guberman, D. ; Hadasch, D. ; Hahn, A. ; Hassan, T. ; Hayashida, M. ; Herrera, J. ; Hose, J. ; Hrupec, D. ; Ishio, K. ; Konno, Y. ; Kubo, H. ; Kushida, J. ; Kuvezdic, D. ; Lelas, D. ; Lindfors, E. ; Lombardi, S. ; Longo, F. ; Lopez, M. ; Maggio, C. ; Majumdar, P. ; Makariev, M. ; Maneva, G. ; Manganaro, M. ; Maraschi, L. ; Mariotti, M. ; Martinez, M. ; Mazin, D. ; Menzel, U. ; Minev, M. ; Miranda, J. M. ; Mirzoyan, R. ; Moralejo, A. ; Moreno, V. ; Moretti, E. ; Nagayoshi, T. ; Neustroev, V. ; Niedzwiecki, A. ; Nievas Rosillo, M. ; Nigro, C. ; Nilsson, K. ; Ninci, D. ; Nishijima, K. ; Noda, K. ; Nogues, L. ; Paiano, S. ; Palacio, J. ; Paneque, D. ; Paoletti, R. ; Paredes, J. M. ; Pedaletti, G. ; Peresano, M. ; Perri, L. ; Persic, M. ; Moroni, P. G. Prada ; Prandini, E. ; Puljak, I. ; Garcia, J. R. ; Reichardt, I. ; Ribo, M. ; Rico, J. ; Righi, C. ; Rugliancich, A. ; Saito, T. ; Satalecka, K. ; Schroeder, S. ; Schweizer, T. ; Shore, S. N. ; Sitarek, J. ; Snidaric, I. ; Sobczynska, D. ; Stamerra, A. ; Strzys, M. ; Suric, T. ; Takalo, L. ; Tavecchio, F. ; Temnikov, P. ; Terzic, T. ; Teshima, M. ; Torres-Alba, N. ; Treves, A. ; Tsujimoto, S. ; Vanzo, G. ; Vazquez Acosta, M. ; Vovk, I. ; Ward, J. E. ; Will, M. ; Zaric, D. ; Arbet-Engels, A. ; Baack, D. ; Balbo, M. ; Biland, A. ; Blank, M. ; Bretz, T. ; Bruegge, K. ; Bulinski, M. ; Buss, J. ; Dmytriiev, A. ; Dorner, D. ; Einecke, S. ; Elsaesser, D. ; Herbst, T. ; Hildebrand, D. ; Kortmann, L. ; Linhoff, L. ; Mahlke, M. ; Mannheim, K. ; Mueller, S. A. ; Neise, D. ; Neronov, A. ; Noethe, M. ; Oberkirch, J. ; Paravac, A. ; Rhode, W. ; Schleicher, B. ; Schulz, F. ; Sedlaczek, K. ; Shukla, A. ; Sliusar, V. ; Walter, R. ; Archer, A. ; Benbow, W. ; Bird, R. ; Brose, Robert ; Buckley, J. H. ; Bugaev, V. ; Christiansen, J. L. ; Cui, W. ; Daniel, M. K. ; Falcone, A. ; Feng, Q. ; Finley, J. P. ; Gillanders, G. H. ; Gueta, O. ; Hanna, D. ; Hervet, O. ; Holder, J. ; Hughes, G. ; Huetten, M. ; Humensky, T. B. ; Johnson, C. A. ; Kaaret, P. ; Kar, P. ; Kelley-Hoskins, N. ; Kertzman, M. ; Kieda, D. ; Krause, M. ; Krennrich, F. ; Kumar, S. ; Lang, M. J. ; Lin, T. T. Y. ; Maier, G. ; McArthur, S. ; Moriarty, P. ; Mukherjee, R. ; Ong, R. A. ; Otte, A. N. ; Park, N. ; Petrashyk, A. ; Pichel, A. ; Pohl, Martin ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Richards, G. T. ; Roache, E. ; Rovero, A. C. ; Rulten, C. ; Sadeh, I. ; Santander, M. ; Sembroski, G. H. ; Shahinyan, K. ; Sushch, I. ; Tyler, J. ; Wakely, S. P. ; Weinstein, A. ; Wells, R. M. ; Wilcox, P. ; Wilhel, A. ; Williams, D. A. ; Williamson, T. J. ; Zitzer, B. ; Perri, M. ; Verrecchia, F. ; Leto, C. ; Villata, M. ; Raiteri, C. M. ; Jorstad, S. G. ; Larionov, V. M. ; Blinov, D. A. ; Grishina, T. S. ; Kopatskaya, E. N. ; Larionova, E. G. ; Nikiforova, A. A. ; Morozova, D. A. ; Troitskaya, Yu. V. ; Troitsky, I. S. ; Kurtanidze, O. M. ; Nikolashvili, M. G. ; Kurtanidze, S. O. ; Kimeridze, G. N. ; Chigladze, R. A. ; Strigachev, A. ; Sadun, A. C.

Aims. We aim to characterize the multiwavelength emission from Markarian 501 (Mrk 501), quantify the energy-dependent variability, study the potential multiband correlations, and describe the temporal evolution of the broadband emission within leptonic theoretical scenarios. Methods. We organized a multiwavelength campaign to take place between March and July of 2012. Excellent temporal coverage was obtained with more than 25 instruments, including the MAGIC, FACT and VERITAS Cherenkov telescopes, the instruments on board the Swift and Fermi spacecraft, and the telescopes operated by the GASP-WEBT collaboration. Results. Mrk 501 showed a very high energy (VHE) gamma-ray flux above 0.2 TeV of similar to 0.5 times the Crab Nebula flux (CU) for most of the campaign. The highest activity occurred on 2012 June 9, when the VHE flux was similar to 3 CU, and the peak of the high-energy spectral component was found to be at similar to 2 TeV. Both the X-ray and VHE gamma-ray spectral slopes were measured to be extremely hard, with spectral indices <2 during most of the observing campaign, regardless of the X-ray and VHE flux. This study reports the hardest Mrk 501 VHE spectra measured to date. The fractional variability was found to increase with energy, with the highest variability occurring at VHE. Using the complete data set, we found correlation between the X-ray and VHE bands; however, if the June 9 flare is excluded, the correlation disappears (significance <3 sigma) despite the existence of substantial variability in the X-ray and VHE bands throughout the campaign. Conclusions. The unprecedentedly hard X-ray and VHE spectra measured imply that their low- and high-energy components peaked above 5 keV and 0.5 TeV, respectively, during a large fraction of the observing campaign, and hence that Mrk 501 behaved like an extreme high-frequency-peaked blazar (EHBL) throughout the 2012 observing season. This suggests that being an EHBL may not be a permanent characteristic of a blazar, but rather a state which may change over time. The data set acquired shows that the broadband spectral energy distribution (SED) of Mrk 501, and its transient evolution, is very complex, requiring, within the framework of synchrotron self-Compton (SSC) models, various emission regions for a satisfactory description. Nevertheless the one-zone SSC scenario can successfully describe the segments of the SED where most energy is emitted, with a significant correlation between the electron energy density and the VHE gamma-ray activity, suggesting that most of the variability may be explained by the injection of high-energy electrons. The one-zone SSC scenario used reproduces the behavior seen between the measured X-ray and VHE gamma-ray fluxes, and predicts that the correlation becomes stronger with increasing energy of the X-rays.

Control of transversal instabilities in reaction-diffusion systems (2018)

Totz, Sonja ; Löber, Jakob ; Totz, Jan Frederik ; Engel, Harald

In two-dimensional reaction-diffusion systems, local curvature perturbations on traveling waves are typically damped out and vanish. However, if the inhibitor diffuses much faster than the activator, transversal instabilities can arise, leading from flat to folded, spatio-temporally modulated waves and to spreading spiral turbulence. Here, we propose a scheme to induce or inhibit these instabilities via a spatio-temporal feedback loop. In a piecewise-linear version of the FitzHugh-Nagumo model, transversal instabilities and spiral turbulence in the uncontrolled system are shown to be suppressed in the presence of control, thereby stabilizing plane wave propagation. Conversely, in numerical simulations with the modified Oregonator model for the photosensitive Belousov-Zhabotinsky reaction, which does not exhibit transversal instabilities on its own, we demonstrate the feasibility of inducing transversal instabilities and study the emerging wave patterns in a well-controlled manner.

The effect of Polycations on the Formation of Magnetite Nanoparticles

Kuhrts, Lucas

Nanoparticles of magnetite (Fe3O4) are envisioned to ﬁnd used in diverse applications, ranging from magnetic data storage, inks, ferroﬂuids as well as in magnetic resonance imaging, drug delivery, and hyperthermia cancer treatment. Their magnetic properties strongly depend on their size and morphology, two properties that can be synthetically controlled. Achieving appropriate control under soft chemical conditions has so far remained a challenging endeavor. One proven way of exerting this desired control has been using a biomimetic approach that emulates the proteome of magnetotactic bacteria by adding poly-L-arginine in the co- precipitation of ferrous and ferric chloride. The objective of the work presented here is to understand the impact of this polycation on the formation mechanism of magnetite and, through rational design, to enhance the control we can exert on magnetite nanoparticle size and morphology. We developed a SAXS setup to temporally and structurally resolve the formation of magnetite in the presence of poly-L-arginine in situ. Using analytical scattering models, we were able to separate the scattering contribution of a low-density 5 nm iron structure from the contribution of the growing nanoparticles. We identiﬁed that the low-density iron structure is a metastable precursor to the magnetite particles and that it is electrostatically stabilized by poly-L-arginine. In a process analogous to biomineralization, the presence of the charged macromolecule thus shifts the reaction mechanism from a thermodynamically controlled one to a kinetically controlled one. We identify this shift in reactions mechanism as the cornerstone of the proposed mechanism and as the crucial step in the paradigm of this extraordinary nanoparticle morphology and size control. Based on SAXS data, theoretical considerations suggest that an observed morphological transition between spherical, solid, and sub-structured mesocrystalline magnetite nanoparticles is induced through a pH-driven change in the wettability of the nanoparticle surface. With these results, we further demonstrate that SAXS can be an invaluable tool for investigating nanoparticle formation. We were able to change particle morphology from spherically solid particles to sub-structured mesocrystals merely by changing the precipitation pH. Improving the synthesis sustainability by substituting poly-L-arginine with renewable, polysaccharide-based polycations produced at the metric ton scale, we demonstrated that the ability to alter the reaction mechanism of magnetite can be generically attributed to the presence of polycations. Through meticulous analysis and the understanding of the formation mechanism, we were able to exert precise control over particle size and morphology, by adapting crucial synthesis parameters. We were thus able to grow mesocrystals up to 200 nm and solid nanocrystals of 100 nm by adding virtually any strong polycation. We further found a way to produce stable single domain magnetite at only slightly increased alkalinity, as magnetotactic bacteria do it. Thus through the understanding of the biological system, the consecutive biomimetic synthesis of magnetite and the following understanding of the mechanism involved in the in vitro synthesis, we managed to improve the synthetic control over the co-precipitation of magnetite, coming close biomineralization of magnetite in magnetotactic bacteria. Polyanions, in both natural as well as in synthetic systems, have been in the spotlight of recent research, yet our work shows the pivotal inﬂuence polycations have on the nucleation of magnetite. This work will contribute signiﬁcantly to our ability to tailor magnetite nanoparticle size and morphology; in addition, we presume it will provide us with a model system for studying biomineralization of magnetite in vitro, putting the spotlight on the important inﬂuence of polycations, which have not had the scientiﬁc attention they deserve.

Optimierung der Leistungsdiagnostik und Entwicklung von effektiven Trainingsprogrammen in der Zweikampfsportart Judo unter Verwendung des Mess- und Informationssystems JERGo für judospezifische Anrissbewegungen (2020)

Helm, Norman

Eine sportartspezifische Anforderungsanalyse ist die Grundlage für die Leistungsdiagnostik und eine wichtige Voraussetzung für die Trainingssteuerung im Spitzensport. Im Rahmen der Leistungsdiagnostik in der Zweikampfsportart Judo besitzen judospezifische Anrissleistungen bei Anrissbewegungen ein hohes Potenzial, um Defizite im Kraft-Weg-Verlauf bzw. in den kinetischen Parametern (z. B. mechanische Arbeit, dynamische Maximalkraft) zu identifizieren und ableitend daraus entsprechende trainingsmethodische Anpassungen zur Verbesserung vorzunehmen. Die Rumpfstabilität und die Rumpfkraft stellen wichtige Leistungsvoraussetzungen für sportliche Bewegungen dar, um den optimalen Transfer von Kräften und Drehmomenten von den unteren Extremitäten über den stabilen Rumpf hin zu den oberen Extremitäten zu ermöglichen. Im Trainingsprozess der Judoka erfährt das spezifische Krafttraining immer mehr Aufmerksamkeit, um die sportartrelevanten Muskelgruppen zu entwickeln und somit die finale Effektivität einer Wurftechnik zu verbessern. Die wesentliche Zielstellung dieser Arbeit bestand darin, die Leistungsdiagnostik im Judo zu optimieren und effektive Trainingsprogramme zur Verbesserung von judospezifischen Anrissbewegungen zu entwickeln. Im Einzelnen wurde dafür eine systematische Anforderungsanalyse für die Sportart Judo erarbeitet. Basierend auf dieser Analyse wurden die Validität und die Reliabilität von kinetischen Parametern während Anrissbewegungen mit einem judospezifischen Ergometer-System (JERGo) untersucht. Zudem wurden die Zusammenhänge zwischen der Rumpfkraft und kinetischen Parametern bei judospezifischen Anrissbewegungen analysiert. Schließlich wurde die Wirksamkeit eines spezifischen Anrisstrainings am JERGo-System gegenüber einem Anrisstraining mit Partner auf kinetische Parameter und Muskelaktivität überprüft. Die sportartspezifische Anforderungsanalyse wurde unter Berücksichtigung der metabolischen und muskulären Anforderungen sowie sportartspezifischen Verletzungsrisiken erarbeitet. An den zwei Querstudien bzw. einer Längsschnittstudie nahmen gesunde männliche Judoka mit unterschiedlichem Expertiseniveau teil. Die kinetischen Parameter bei judospezifischen Anrissbewegungen wurden mit dem JERGo-System in allen Experimentalstudien erfasst. Die Rumpfkraft wurde mit einem isokinetischen Dynamometer gemessen, um Assoziationen zwischen der Rumpfkraft und judospezifischen Anrissleistungen zu bestimmen. Zudem wurde die Aktivität ausgewählter Rumpf-/Schultermuskeln bei der Anrissbewegung im Standfür die Validierung des JERGo-Systems und für die Überprüfung der Effekte eines Anrisstrainings erfasst. Die Ermittlung von sportmotorischen Leistungen erfolgte durch die Übungen Liegend-Anreißen und Klimmziehen, um die Wirkungen eines judospezifischen Anrisstrainings auf sportartunspezifische Kraftleistungen zu untersuchen. Unter Berücksichtigung der muskulären Anforderungen im Judo wird die Ausführung einer explosiven Anrissbewegung bzw. Wurftechnik durch die koordinierte Aktivität vieler Muskelgruppen und vor allem durch die unteren Extremitäten sowie den Rumpf realisiert. Aus trainingswissenschaftlicher Sicht ist das JERGo-System ein valides und reliables Messinstrument für die Diagnostik von kinetischen Parametern während judospezifischer Anrissbewegungen. Die Rumpfkraft, insbesondere bei der Rumpfrotation, ist mit kinetischen Parametern bei judospezifischen Anrissbewegungen assoziiert. Ein Anrisstraining am JERGo-System zeigt in den kinetischen Parametern und Muskelaktivierungen vor allem bei der Anrissbewegung im Stand signifikant größere Zuwachsraten im Vergleich zu einem Anrisstraining mit Partner. Die Ergebnisse dieser Arbeit zeigen, dass die Verbesserung der muskulären Leistungsfähigkeit (z. B. Explosivkraft) in den unteren Extremitäten und der Rumpfmuskulatur eine wichtige Basis für judospezifische Anrissleistungen bei Anrissbewegungen und Wurftechniken darstellt. Zudem empfiehlt es sich, dass JERGo-System zur Diagnostik von kinetischen Parametern bei judospezifischen Anrissbewegungen in die judospezifische Testbatterie einzubinden. Weiterhin kann davon ausgegangen werden, dass durch rumpfextensions- und vor allem durch rumpfrotationskräftigende Übungen unter maximal schellkräftigender Muskelaktivierung Einfluss auf kinetische Parameter bei judospezifischen Anrissbewegungen genommen wird. Letztendlich empfiehlt es sich, ein Antrisstraining am JERGo-System in den judospezifischen Trainingsprozess zu integrieren.

From dawn till dusk (2020)

Brose, Robert

Supernova remnants are believed to be the source of cosmic rays with energies up to 10^15 eV that are produced within our Galaxy. The acceleration mechanism associated with the collision-less shocks in supernova remnants - diffusive shock acceleration - predicts a spectral index of the accelerated non-thermal particles of s = 2. However, measurements of non-thermal emission in radio, X-rays and gamma-rays reveal significant deviations of the particles spectral index from the canonical value of s = 2. The youngest Galactic supernova remnant G1.9+0.3 is an interesting target for next-generation gamma-ray observatories. So far, the remnant is only detected in the radio and the X-ray bands, but its young age of ≈100 yrs and inferred shock speed of ≈ 14, 000 km/s could make it an efficient particle accelerator. I performed spherical symmetric 1D simulations with the RATPaC code, in which I simultaneously solved the transport equation for cosmic rays, the transport equation for magnetic turbulence, and the hydro-dynamical equations for the gas flow. Separately computed distributions of the particles accelerated at the forward and the reverse shock were then used to calculate the spectra of synchrotron, inverse Compton, and Pion-decay radiation from the source. The emission from G1.9+0.3 can be self-consistently explained within the test-particle limit. I find that the X-ray flux is dominated by emission from the forward shock while most of the radio emission originates near the reverse shock, which makes G1.9+0.3 the first remnant with non-thermal radiation detected from the reverse shock. The flux of very-high-energy gamma-ray emission from G1.9+0.3 is expected to be close to the sensitivity threshold of the Cherenkov Telescope Array. The limited time available to grow large-scale turbulence limits the maximum energy of particles to values below 100 TeV, hence G1.9+0.3 is not a PeVatron. Although there are many models for the acceleration of cosmic rays in Supernova remnants, the escape of cosmic rays from these sources is yet understudied. I use our time-dependent acceleration code RATPaC to study the acceleration of cosmic rays and their escape in post-adiabatic Supernova remnants and calculate the subsequent gamma-ray emission from inverse-Compton scattering and Pion decay. My simulations span 100,000 years, thus covering the free-expansion, the Sedov-Taylor, and the beginning of the post-adiabatic phase of the remnant’s evolution. At later stages of the evolution cosmic rays over a wide range of energy can reside outside of the remnant, creating spectra that are softer than predicted by standard diffusive shock acceleration and feature breaks in the 10 - 100 GeV-range. The total spectrum of cosmic rays released into the interstellar medium has a spectral index of s ≈ 2.4 above roughly 10 GeV which is close to that required by Galactic propagation models. I further find the gamma-ray luminosity to peak around an age of 4,000 years for inverse-Compton-dominated high-energy emission. Remnants expanding in low-density media emit generally more inverse-Compton radiation matching the fact that the brightest known supernova remnants - RCW86, Vela Jr, HESSJ1721-347 and RXJ1713.7-3946 - are all expanding in low density environments. The importance of feedback from the cosmic-rays on the hydrodynamical evolution of the remnants is debated as a possibility to obtain soft cosmic-ray spectra at low energies. I performed spherically symmetric 1-D simulations with a modified version of the RATPaC code, in which I simultaneously solve the transport equation for cosmic rays and the hydrodynamical equations, including the back-reaction of the cosmic-ray pressure on the flow profiles. Besides the known modification of the flow profiles and the consequently curved cosmic-ray spectra, steady-state models for non-linear diffusive shock acceleration overpredict the total compression ratio that can be reached with cosmic-ray feedback, as there is limited time for building these modifications. Further, I find modifications to the downstream flow structure that change the evolutionary behavior of the remnant and trigger a cosmic-ray-induced instability close to the contact discontinuity, if and when the cosmic-ray pressure becomes dominant there.

Portal = Bioökonomie (2020)

Kampe, Heike ; Zimmermann, Matthias ; Horn-Conrad, Antje ; Scholz, Jana ; Pchalek, Magda ; Szameitat, Ulrike ; Engel, Silke ; Eckardt, Barbara

Ein bisschen sperrig ist es schon, dieses Wort: Bioökonomie. Noch ist es vielleicht nicht in aller Munde, aber das könnte sich dieses Jahr ändern. Immerhin ist es das Thema des Wissenschaftsjahres 2020. Und selbst wenn „Bioökonomie“ dem einen oder anderen schwer über die Lippen geht – sie umgibt uns bereits. Das lässt sich auch an den zahlreichen Projekten erkennen, die sich an der Universität Potsdam mit der nachhaltigen Nutzung nachwachsender Ressourcen beschäftigen. In dieser Ausgabe des Unimagazins Portal stellen wir Ihnen Menschen vor, die Bausteine erarbeiten für eine moderne, biobasierte Wirtschaft, die biologische Materialien, Pflanzen, Tiere und Mikroorganismen umweltschonend und effizient nutzt. Eine brandenburgische Initiative zum Beispiel bringt Landwirte und Lehrer, Vertreter aus Verwaltung, Einzelhandel oder Umweltorganisationen zur bioökonomischen Wende ins Gespräch. Eine Informatikerin und eine Agrarwissenschaftlerin erklären, was die Digitalisierung in der Landwirtschaft leisten kann, und wir erfahren, wie die Universität weiter Treibhausgase einsparen wird. Ernährungswissenschaftler kultivieren Algen und Salzpflanzen, um unseren Gaumen an veränderte (land-)wirtschaftliche Bedingungen zu gewöhnen. Ob schon Alexander von Humboldt die Welt durch die Bioökonomie- Brille gesehen hat? Wie entwickeln Chemiker abbaubare Polymere? Und wie können Heilpflanzen Tropenkrankheiten bekämpfen? All dies in unserer Titelgeschichte. Wie immer haben wir uns auch auf dem Campus umgesehen und und dabei interessante Geschichten aufgespürt. Wie studiert es sich eigentlich mit Mitte 60 – und wie ist es, als Schüler Uni-Luft zu schnuppern? Sie erfahren, wer außer Studierenden und Beschäftigten noch in den Hallen des Hochschulsports boxt und warum es so wichtig ist, sich für die Belange ausländischer Studierender einzusetzen. Botaniker zeigen uns die Flora Sansibars und zwei junge Gärtner nehmen uns mit in die Potsdamer Pflanzenwelt; wir erfahren, warum botanisches Wissen gar nicht altmodisch ist und Ernten auch Studierenden Spaß macht. Ein Spitzensportler mit Aussichten auf Olympia erklärt, warum fünf Sportarten besser sind als eine. Wir haben uns über die Gender Studies informiert und über neue Lernroboter an Schulen. Lesen Sie, wie die Universitätsschule aussehen kann und ob der Amerikanische Traum wahr geworden ist! Ob Vitamin C in der Krebstherapie eingesetzt werden könnte, warum sich ein Besuch in deutschen Geoparks lohnt und wie sich Rechtsextremismus in Deutschland entwickelt – wir haben uns schlau gemacht. 15 unverblümte Fragen hat uns ein Ernährungswissenschaftler beantwortet. Und wir wollten noch mehr wissen: Wie das Wetter eigentlich bei Shakespeare ist, warum das Lehramt der tollste Beruf der Welt ist, wie die Potsdamer Konferenz die Welt veränderte und welche optischen Schätze sich im Fotoarchiv der Uni Potsdam verbergen. Zuletzt erfreuen Sie sich doch an einigen verbalen Schätzen, die hier und da an der Universität gehoben werden.

Lösungen und Leitfäden für das institutionelle Forschungsdatenmanagement (2019)

Hartmann, Niklas K. ; Helbig, Kerstin ; Biernacka, Katarzyna ; Buchholz, Petra ; Dolzycka, Dominika ; Hartmann, Thomas ; Hiemenz, Bea ; Jacob, Boris ; Kuberek, Monika ; Weiß, Nadin ; Dreyer, Malte

Hochschulen und deren Zentraleinrichtungen beschäftigen sich zunehmend mit dem Thema Forschungsdatenmanagement (FDM), um ihre Forschenden adäquat zu unterstützen. Nicht zuletzt aufgrund neuer Verlags- und Förderanforderungen wünschen sich Forschende Beratung und Orientierung, wie sie mit ihren Forschungsdaten umgehen sollen. Damit Hochschulen schnell und nachhaltig Lösungen zum institutionellen FDM etablieren können, haben fünf Berliner und Brandenburger Universitäten im gemeinsamen Verbundvorhaben FDMentor mit Förderung des Bundesministeriums für Bildung und Forschung (BMBF) entsprechende Leitfäden und Werkzeuge erarbeitet. Die innerhalb von zwei Jahren (2017–2019) entstandenen Ergebnisse in den Bereichen Strategieentwicklung, Forschungsdaten-Policy, rechtliche Aspekte und Kompetenzausbau finden über das Verbundprojekt hinaus ihre Anwendung.

Purposiveness of nature in Kant's third critique (2020)

Menting, Thijs

This dissertation aims to deliver a transcendental interpretation of Immanuel Kant's Kritik der Urteilskraft, considering both its coherence with other critical works as well as the internal coherence of the work itself. This interpretation is called transcendental insofar as special emphasis is placed on the newly introduced cognitive power, namely the reflective power of judgement, guided by the a priori principle of purposiveness. In this way the seeming manifold of themes, varying from judgements of taste through culture to teleological judgements about natural purposes, are discussed exclusively in regard of their dependence on this faculty and its transcendental principle. In contrast, in contemporary scholarship the book is often treated as a fragmented work, consisting of different independent parts, while my focus lies on the continuity comprised primarily of the activity of the power of judgement. Going back to certain central yet silently presupposed concepts, adopted from previous critical works, the main contribution of this study is to integrate the KU within the overarching critical project. More specifically, I have argue how the need for the presupposition by the reflective power of judgement follows from the peculiar character of our sense-dependent discursive mind. Because we are sense-dependent discursive minds, we do not and cannot have immediate insight into all of nature's features. The particular constitution of our mind rather demands conceptually informed representations which mediately refer to objects. Having said that, the principle of purposiveness, namely the presupposition that nature is organized in concert with the particular constitution of our mind, is a necessary condition for the possibility of reflection on nature's empirical features. Reflection refers on my account to a process of selecting features in order to allow a classification, including reflection on the method, means and selection criteria. Rather than directly contributing to cognition, like the categories, reflective judgements thus express our ignorance when it comes to the motivation behind nature's design, and this is most forcefully expressed by judgements of taste and teleological judgements about organized matter. In this way, reflection, regardless whether it is manifested in concept acquisition, scientific systematization, judgements of taste or judgements about organized matter, relies on a principle of the power of judgement which is revealed and justified in this transcendental inquiry.

Energy transfer between tm-doped upconverting nanoparticles and a small organic dye with large stokes shift (2019)

López de Guereñu, Anna ; Bastian, Philipp ; Wessig, Pablo ; John, Leonard ; Kumke, Michael U.

Lanthanide-doped upconverting nanoparticles (UCNP) are being extensively studied for bioapplications due to their unique photoluminescence properties and low toxicity. Interest in RET applications involving UCNP is also increasing, but due to factors such as large sizes, ion emission distributions within the particles, and complicated energy transfer processes within the UCNP, there are still many questions to be answered. In this study, four types of core and core-shell NaYF4-based UCNP co-doped with Yb3+ and Tm3+ as sensitizer and activator, respectively, were investigated as donors for the Methyl 5-(8-decanoylbenzo[1,2-d:4,5-d ']bis([1,3]dioxole)-4-yl)-5-oxopentanoate (DBD-6) dye. The possibility of resonance energy transfer (RET) between UCNP and the DBD-6 attached to their surface was demonstrated based on the comparison of luminescence intensities, band ratios, and decay kinetics. The architecture of UCNP influenced both the luminescence properties and the energy transfer to the dye: UCNP with an inert shell were the brightest, but their RET efficiency was the lowest (17%). Nanoparticles with Tm3+ only in the shell have revealed the highest RET efficiencies (up to 51%) despite the compromised luminescence due to surface quenching.

Hasidic myth-activism (2019)

Hadad, Yemima

Since the 1970s, Buber has often been suspected of being a Volkish thinker. This essay reconsiders the affinity of Buber's late writings with Volkish ideology. It examines the allegations against Buber's Volkish thought in light of his later biblical and Hasidic writings. By illuminating the ideological affinity between these two modes of thought, the essay explains how Buber aims to depart from the dangers of myth without rejecting myth as such. I argue that Buber's relationship to myth can help us to explain his critique of nationalism. My basic argument is that in his struggle with hyper-nationalism, Buber follows the Baal Shem Tov and his struggle against Sabbateanism. Like the Besht, Buber does not reject myth, but seeks instead to repair it from within. Whereas hyper-nationalism uses myth to advance its political goals, Buber seeks to reposition ethics within a mythic framework. I view Buber's exegesis and commentaries on biblical and Hasidic myths as myth-activism.

From structural fluctuations to vibrational spectroscopy of adsorbates on surfaces (2019)

Melani, Giacomo

Aluminum oxide is an Earth-abundant geological material, and its interaction with water is of crucial importance for geochemical and environmental processes. Some aluminum oxide surfaces are also known to be useful in heterogeneous catalysis, while the surface chemistry of aqueous oxide interfaces determines the corrosion, growth and dissolution of such materials. In this doctoral work, we looked mainly at the (0001) surface of α-Al 2 O 3 and its reactivity towards water. In particular, a great focus of this work is dedicated to simulate and address the vibrational spectra of water adsorbed on the α-alumina(0001) surface in various conditions and at different coverages. In fact, the main source of comparison and inspiration for this work comes from the collaboration with the “Interfacial Molecular Spectroscopy” group led by Dr. R. Kramer Campen at the Fritz-Haber Institute of the MPG in Berlin. The expertise of our project partners in surface-sensitive Vibrational Sum Frequency (VSF) generation spectroscopy was crucial to develop and adapt specific simulation schemes used in this work. Methodologically, the main approach employed in this thesis is Ab Initio Molecular Dynamics (AIMD) based on periodic Density Functional Theory (DFT) using the PBE functional with D2 dispersion correction. The analysis of vibrational frequencies from both a static and a dynamic, finite-temperature perspective offers the ability to investigate the water / aluminum oxide interface in close connection to experiment. The first project presented in this work considers the characterization of dissociatively adsorbed deuterated water on the Al-terminated (0001) surface. This particular structure is known from both experiment and theory to be the thermodynamically most stable surface termination of α-alumina in Ultra-High Vacuum (UHV) conditions. Based on experiments performed by our colleagues at FHI, different adsorption sites and products have been proposed and identified for D 2 O. While previous theoretical investigations only looked at vibrational frequencies of dissociated OD groups by staticNormal Modes Analysis (NMA), we rather employed a more sophisticated approach to directly assess vibrational spectra (like IR and VSF) at finite temperature from AIMD. In this work, we have employed a recent implementation which makes use of velocity-velocity autocorrelation functions to simulate such spectral responses of O-H(D) bonds. This approach allows for an efficient and qualitatively accurate estimation of Vibrational Densities of States (VDOS) as well as IR and VSF spectra, which are then tested against experimental spectra from our collaborators. In order to extend previous work on unimolecularly dissociated water on α-Al 2 O 3 , we then considered a different system, namely, a fully hydroxylated (0001) surface, which results from the reconstruction of the UHV-stable Al-terminated surface at high water contents. This model is then further extended by considering a hydroxylated surface with additional water molecules, forming a two-dimensional layer which serves as a potential template to simulate an aqueous interface in environmental conditions. Again, employing finite-temperature AIMD trajectories at the PBE+D2 level, we investigated the behaviour of both hydroxylated surface (HS) and the water-covered structure derived from it (known as HS+2ML). A full range of spectra, from VDOS to IR and VSF, is then calculated using the same methodology, as described above. This is the main focus of the second project, reported in Chapter 5. In this case, comparison between theoretical spectra and experimental data is definitely good. In particular, we underline the nature of high-frequency resonances observed above 3700 cm −1 in VSF experiments to be associated with surface OH-groups, known as “aluminols” which are a key fingerprint of the fully hydroxylated surface. In the third and last project, which is presented in Chapter 6, the extension of VSF spectroscopy experiments to the time-resolved regime offered us the opportunity to investigate vibrational energy relaxation at the α-alumina / water interface. Specifically, using again DFT-based AIMD simulations, we simulated vibrational lifetimes for surface aluminols as experimentally detected via pump-probe VSF. We considered the water-covered HS model as a potential candidate to address this problem. The vibrational (IR) excitation and subsequent relaxation is performed by means of a non-equilibrium molecular dynamics scheme. In such a scheme, we specifically looked at the O-H stretching mode of surface aluminols. Afterwards, the analysis of non-equilibrium trajectories allows for an estimation of relaxation times in the order of 2-4 ps which are in overall agreement with measured ones. The aim of this work has been to provide, within a consistent theoretical framework, a better understanding of vibrational spectroscopy and dynamics for water on the α-alumina(0001) surface,ranging from very low water coverage (similar to the UHV case) up to medium-high coverages, resembling the hydroxylated oxide in environmental moist conditions.

HiN : Alexander von Humboldt im Netz (2020)

Knobloch, Eberhard ; Päßler, Ulrich ; García Cruz, Cándido Manuel ; Krumpel, Sebastian ; Männl, Ingrid ; Pinsdorf, Christina ; Schladebach, Marcus

-Eberhard Knobloch, Ulrich Päßler: Ein unbekannter Brief Alexander von Humboldts an Friedrich August Wolf (1817) -Cándido Manuel García Cruz: Alexander von Humboldt y los fósiles inorgánicos de las islas canarias -Sebastian Krumpel: Zur quantitativen Auswertung der intertextuellen Bezüge Humboldts in seinem Essai politique sur le royaume de la Nouvelle-Espagne -Ingrid Männl: „… durch die Bereisung der dargestellten Gegenden der Wissenschaft und ihrer Nation ein so schönes Denkmal gesetzt …“. Zu Friedrich Georg Weitschs Gemälde, das Alexander von Humboldt und Aimé Bonpland vor dem Chimborazo zeigt -Christina Pinsdorf: Romantischer Empirismus im Anthropozän. A. v. Humboldts und F. W. J. Schellings Ideen für die Environmental Humanities -Marcus Schladebach: Alexander von Humboldt als Völkerrechtler

Globalisierung à la carte (2017)

Dieter, Heribert

Reconstructing democracy (2020)

Taylor, Charles ; Nanz, Patrizia ; Taylor, Madeleine Beaubien

Across the world, democracies are suffering from a disconnect between the people and political elites. In communities where jobs and industry are scarce, many feel the government is incapable of understanding their needs or addressing their problems. The resulting frustration has fueled the success of destabilizing demagogues. To reverse this pattern and restore responsible government, we need to reinvigorate democracy at the local level. But what does that mean? Drawing on examples of successful community building in cities large and small, from a shrinking village in rural Austria to a neglected section of San Diego, Reconstructing Democracy makes a powerful case for re-engaging citizens. It highlights innovative grassroots projects and shows how local activists can form alliances and discover their own power to solve problems.

Structural kinetic modeling of metabolic networks (2006)

Steuer, Ralf ; Gross, Thilo ; Selbig, Joachim ; Blasius, Bernd

To develop and investigate detailed mathematical models of metabolic processes is one of the primary challenges in systems biology. However, despite considerable advance in the topological analysis of metabolic networks, kinetic modeling is still often severely hampered by inadequate knowledge of the enzyme-kinetic rate laws and their associated parameter values. Here we propose a method that aims to give a quantitative account of the dynamical capabilities of a metabolic system, without requiring any explicit information about the functional form of the rate equations. Our approach is based on constructing a local linear model at each point in parameter space, such that each element of the model is either directly experimentally accessible or amenable to a straightforward biochemical interpretation. This ensemble of local linear models, encompassing all possible explicit kinetic models, then allows for a statistical exploration of the comprehensive parameter space. The method is exemplified on two paradigmatic metabolic systems: the glycolytic pathway of yeast and a realistic-scale representation of the photosynthetic Calvin cycle.

Proceedings of the XI international conference stochastic and analytic methods in mathematical physics (2020)

Zass, Alexander ; Zagrebnov, Valentin ; Sukiasyan, Hayk ; Melkonyan, Tatev ; Rafler, Mathias ; Poghosyan, Suren ; Zessin, Hans ; Piatnitski, Andrey ; Zhizhina, Elena ; Pechersky, Eugeny ; Pirogov, Sergei ; Yambartsev, Anatoly ; Mazzonetto, Sara ; Lykov, Alexander ; Malyshev, Vadim ; Khachatryan, Linda ; Nahapetian, Boris ; Jursenas, Rytis ; Jansen, Sabine ; Tsagkarogiannis, Dimitrios ; Kuna, Tobias ; Kolesnikov, Leonid ; Hryniv, Ostap ; Wallace, Clare ; Houdebert, Pierre ; Figari, Rodolfo ; Teta, Alessandro ; Boldrighini, Carlo ; Frigio, Sandro ; Maponi, Pierluigi ; Pellegrinotti, Alessandro ; Sinai, Yakov G.

The XI international conference Stochastic and Analytic Methods in Mathematical Physics was held in Yerevan 2 – 7 September 2019 and was dedicated to the memory of the great mathematician Robert Adol’fovich Minlos, who passed away in January 2018. The present volume collects a large majority of the contributions presented at the conference on the following domains of contemporary interest: classical and quantum statistical physics, mathematical methods in quantum mechanics, stochastic analysis, applications of point processes in statistical mechanics. The authors are specialists from Armenia, Czech Republic, Denmark, France, Germany, Italy, Japan, Lithuania, Russia, UK and Uzbekistan. A particular aim of this volume is to offer young scientists basic material in order to inspire their future research in the wide fields presented here.

Three empirical essays in health economics (2019)

Wozny, Florian

Modern health care systems are characterized by pronounced prevention and cost-optimized treatments. This dissertation offers novel empirical evidence on how useful such measures can be. The first chapter analyzes how radiation, a main pollutant in health care, can negatively affect cognitive health. The second chapter focuses on the effect of Low Emission Zones on public heath, as air quality is the major external source of health problems. Both chapters point out potentials for preventive measures. Finally, chapter three studies how changes in treatment prices affect the reallocation of hospital resources. In the following, I briefly summarize each chapter and discuss implications for health care systems as well as other policy areas. Based on the National Educational Panel Study that is linked to data on radiation, chapter one shows that radiation can have negative long-term effects on cognitive skills, even at subclinical doses. Exploiting arguably exogenous variation in soil contamination in Germany due to the Chernobyl disaster in 1986, the findings show that people exposed to higher radiation perform significantly worse in cognitive tests 25 years later. Identification is ensured by abnormal rainfall within a critical period of ten days. The results show that the effect is stronger among older cohorts than younger cohorts, which is consistent with radiation accelerating cognitive decline as people get older. On average, a one-standarddeviation increase in the initial level of CS137 (around 30 chest x-rays) is associated with a decrease in the cognitive skills by 4.1 percent of a standard deviation (around 0.05 school years). Chapter one shows that sub-clinical levels of radiation can have negative consequences even after early childhood. This is of particular importance because most of the literature focuses on exposure very early in life, often during pregnancy. However, population exposed after birth is over 100 times larger. These results point to substantial external human capital costs of radiation which can be reduced by choices of medical procedures. There is a large potential for reductions because about one-third of all CT scans are assumed to be not medically justified (Brenner and Hall, 2007). If people receive unnecessary CT scans because of economic incentives, this chapter points to additional external costs of health care policies. Furthermore, the results can inform the cost-benefit trade-off for medically indicated procedures. Chapter two provides evidence about the effectiveness of Low Emission Zones. Low Emission Zones are typically justified by improvements in population health. However, there is little evidence about the potential health benefits from policy interventions aiming at improving air quality in inner-cities. The chapter ask how the coverage of Low Emission Zones air pollution and hospitalization, by exploiting variation in the roll out of Low Emission Zones in Germany. It combines information on the geographic coverage of Low Emission Zones with rich panel data on the universe of German hospitals over the period from 2006 to 2016 with precise information on hospital locations and the annual frequency of detailed diagnoses. In order to establish that our estimates of Low Emission Zones’ health impacts can indeed be attributed to improvements in local air quality, we use data from Germany’s official air pollution monitoring system and assign monitor locations to Low Emission Zones and test whether measures of air pollution are affected by the coverage of a Low Emission Zone. Results in chapter two confirm former results showing that the introduction of Low Emission Zones improved air quality significantly by reducing NO2 and PM10 concentrations. Furthermore, the chapter shows that hospitals which catchment areas are covered by a Low Emission Zone, diagnose significantly less air pollution related diseases, in particular by reducing the incidents of chronic diseases of the circulatory and the respiratory system. The effect is stronger before 2012, which is consistent with a general improvement in the vehicle fleet’s emission standards. Depending on the disease, a one-standard-deviation increase in the coverage of a hospitals catchment area covered by a Low Emission Zone reduces the yearly number of diagnoses up to 5 percent. These findings have strong implications for policy makers. In 2015, overall costs for health care in Germany were around 340 billion euros, of which 46 billion euros for diseases of the circulatory system, making it the most expensive type of disease caused by 2.9 million cases (Statistisches Bundesamt, 2017b). Hence, reductions in the incidence of diseases of the circulatory system may directly reduce society’s health care costs. Whereas chapter one and two study the demand-side in health care markets and thus preventive potential, chapter three analyzes the supply-side. By exploiting the same hospital panel data set as in chapter two, chapter three studies the effect of treatment price shocks on the reallocation of hospital resources in Germany. Starting in 2005, the implementation of the German-DRG-System led to general idiosyncratic treatment price shocks for individual hospitals. Thus far there is little evidence of the impact of general price shocks on the reallocation of hospital resources. Additionally, I add to the exiting literature by showing that price shocks can have persistent effects on hospital resources even when these shocks vanish. However, simple OLS regressions would underestimate the true effect, due to endogenous treatment price shocks. I implement a novel instrument variable strategy that exploits the exogenous variation in the number of days of snow in hospital catchment areas. A peculiarity of the reform allowed variation in days of snow to have a persistent impact on treatment prices. I find that treatment price increases lead to increases in input factors such as nursing staff, physicians and the range of treatments offered but to decreases in the treatment volume. This indicates supplier-induced demand. Furthermore, the probability of hospital mergers and privatization decreases. Structural differences in pre-treatment characteristics between hospitals enhance these effects. For instance, private and larger hospitals are more affected. IV estimates reveal that OLS results are biased towards zero in almost all dimensions because structural hospital differences are correlated with the reallocation of hospital resources. These results are important for several reasons. The G-DRG-Reform led to a persistent polarization of hospital resources, as some hospitals were exposed to treatment price increases, while others experienced reductions. If hospitals increase the treatment volume as a response to price reductions by offering unnecessary therapies, it has a negative impact on population wellbeing and public spending. However, results show a decrease in the range of treatments if prices decrease. Hospitals might specialize more, thus attracting more patients. From a policy perspective it is important to evaluate if such changes in the range of treatments jeopardize an adequate nationwide provision of treatments. Furthermore, the results show a decrease in the number of nurses and physicians if prices decrease. This could partly explain the nursing crisis in German hospitals. However, since hospitals specialize more they might be able to realize efficiency gains which justify reductions in input factors without loses in quality. Further research is necessary to provide evidence for the impact of the G-DRG-Reform on health care quality. Another important aspect are changes in the organizational structure. Many public hospitals have been privatized or merged. The findings show that this is at least partly driven by the G-DRG-Reform. This can again lead to a lack in services offered in some regions if merged hospitals specialize more or if hospitals are taken over by ecclesiastical organizations which do not provide all treatments due to moral conviction. Overall, this dissertation reveals large potential for preventive health care measures and helps to explain reallocation processes in the hospital sector if treatment prices change. Furthermore, its findings have potentially relevant implications for other areas of public policy. Chapter one identifies an effect of low dose radiation on cognitive health. As mankind is searching for new energy sources, nuclear power is becoming popular again. However, results of chapter one point to substantial costs of nuclear energy which have not been accounted yet. Chapter two finds strong evidence that air quality improvements by Low Emission Zones translate into health improvements, even at relatively low levels of air pollution. These findings may, for instance, be of relevance to design further policies targeted at air pollution such as diesel bans. As pointed out in chapter three, the implementation of DRG-Systems may have unintended side-effects on the reallocation of hospital resources. This may also apply to other providers in the health care sector such as resident doctors.

A'-movement dependencies and their reflexes in Igbo (2020)

Amaechi, Mary

In this thesis, I examine different A-bar movement dependencies in Igbo, a Benue-Congo language spoken in southern Nigeria. Movement dependencies are found in constructions where an element is moved to the left edge of the clause to express information-structural categories such as in questions, relativization and focus. I show that these constructions in Igbo are very uniform from a syntactic point of view. The constructions are built on two basic fronting operations: relativization and focus movement, and are biclausal. I further investigate several morphophonological effects that are found in these A-bar constructions. I propose that these effects are reflexes of movement that are triggered when an element is moved overtly in relativization or focus. This proposal helps to explain the tone patterns that have previously been assumed to be a property of relative clauses. The thesis adds to the growing body of tonal reflexes of A-bar movement reported for a few African languages. The thesis also provides an insight into the complementizer domain (C-domain) of Igbo.

How reliable is the electrochemical readout of MIP-sensors? (2020)

Yarman, Aysu ; Scheller, Frieder W.

Electrochemical methods offer the simple characterization of the synthesis of molecularly imprinted polymers (MIPs) and the readouts of target binding. The binding of electroinactive analytes can be detected indirectly by their modulating effect on the diffusional permeability of a redox marker through thin MIP films. However, this process generates an overall signal, which may include nonspecific interactions with the nonimprinted surface and adsorption at the electrode surface in addition to (specific) binding to the cavities. Redox-active low-molecular-weight targets and metalloproteins enable a more specific direct quantification of their binding to MIPs by measuring the faradaic current. The in situ characterization of enzymes, MIP-based mimics of redox enzymes or enzyme-labeled targets, is based on the indication of an electroactive product. This approach allows the determination of both the activity of the bio(mimetic) catalyst and of the substrate concentration.

Psychosocial health risk factors and resources of medical students and physicians (2008)

Voltmer, Edgar ; Kieschke, Ulf ; Schwappach, David L.B. ; Wirsching, Michael ; Spahn, Claudia

Background Epidemiological data indicate elevated psychosocial health risks for physicians, e.g., burnout, depression, marital disturbances, alcohol and substance abuse, and suicide. The purpose of this study was to identify psychosocial health resources and risk factors in profession-related behaviour and experience patterns of medical students and physicians that may serve as a basis for appropriate health promoting interventions. Methods The questionnaire -Related Behaviour and Experience "Work administered in cross-sectional surveys to students in the first (n = 475) and in the fifth year of studies (n = 355) in required courses at three German universities and to physicians in early professional life in the vicinity of these universities (n = 381). Results Scores reflecting a healthy behaviour pattern were less likely in physicians (16.7%) compared to 5th year (26.0%) and 1st year students (35.1%) while scores representing unambitious and resigned patterns were more common among physicians (43.4% vs. 24.4% vs. 41.0% and 27.3% vs. 17.2% vs. 23.3 respectively). Female and male responders differed in the domains professional commitment, resistance to stress and emotional well-being. Female physicians on average scored higher in the dimensions resignation tendencies, satisfaction with life and experience of social support, and lower in career ambition. Conclusion The results show distinct psychosocial stress patterns among medical students and physicians. Health promotion and prevention of psychosocial symptoms and impairments should be integrated as a required part of the medical curriculum and be considered an important issue during the further training of physicians.

"Lomonosov" satellite-space observatory to study extreme phenomena in space (2017)

Sadovnichii, V. A. ; Panasyuk, M. I. ; Amelyushkin, A. M. ; Benghin, V. V. ; Garipov, G. K. ; Kalegaev, V. V. ; Klimov, P. A. ; Khrenov, B. A. ; Petrov, V. L. ; Sharakin, S. A. ; Shirokov, A. V. ; Svertilov, S. I. ; Zotov, M. Y. ; Yashin, I. V. ; Gorbovskoy, E. S. ; Lipunov, V. M. ; Park, I. H. ; Lee, J. ; Jeong, S. ; Kim, M. B. ; Jeong, H. M. ; Shprits, Yuri Y. ; Angelopoulos, V. ; Russell, C. T. ; Runov, A. ; Turner, D. ; Strangeway, R. J. ; Caron, R. ; Biktemerova, S. ; Grinyuk, A. ; Lavrova, M. ; Tkachev, L. ; Tkachenko, A. ; Martinez, O. ; Salazar, H. ; Ponce, E.

The "Lomonosov" space project is lead by Lomonosov Moscow State University in collaboration with the following key partners: Joint Institute for Nuclear Research, Russia, University of California, Los Angeles (USA), University of Pueblo (Mexico), Sungkyunkwan University (Republic of Korea) and with Russian space industry organi-zations to study some of extreme phenomena in space related to astrophysics, astroparticle physics, space physics, and space biology. The primary goals of this experiment are to study: -Ultra-high energy cosmic rays (UHECR) in the energy range of the Greizen-ZatsepinKuzmin (GZK) cutoff; -Ultraviolet (UV) transient luminous events in the upper atmosphere; -Multi-wavelength study of gamma-ray bursts in visible, UV, gamma, and X-rays; -Energetic trapped and precipitated radiation (electrons and protons) at low-Earth orbit (LEO) in connection with global geomagnetic disturbances; -Multicomponent radiation doses along the orbit of spacecraft under different geomagnetic conditions and testing of space segments of optical observations of space-debris and other space objects; -Instrumental vestibular-sensor conflict of zero-gravity phenomena during space flight. This paper is directed towards the general description of both scientific goals of the project and scientific equipment on board the satellite. The following papers of this issue are devoted to detailed descriptions of scientific instruments.

Automatic affective reactions to exercise-related stimuli (2020)

Schinkoeth, Michaela

Even though the majority of individuals know that exercising is healthy, a high percentage struggle to achieve the recommended amount of exercise. The (social-cognitive) theories that are commonly applied to explain exercise motivation refer to the assumption that people base their decisions mainly on rational reasoning. However, behavior is not only bound to reflection. In recent years, the role of automaticity and affect for exercise motivation has been increasingly discussed. In this dissertation, central assumptions of the affective–reflective theory of physical inactivity and exercise (ART; Brand & Ekkekakis, 2018), an exercise-specific dual-process theory that emphasizes the role of a momentary automatic affective reaction for exercise-decisions, were examined. The central aim of this dissertation was to investigate exercisers and non-exercisers automatic affective reactions to exercise-related stimuli (i.e., type-1 process). In particular, the two components of the ART’s type-1 process, that are, automatic associations with exercise and the automatic affective valuation to exercise, were under study. In the first publication (Schinkoeth & Antoniewicz, 2017), research on automatic (evaluative) associations with exercise was summarized and evaluated in a systematic review. The results indicated that automatic associations with exercise appeared to be relevant predictors for exercise behavior and other exercise-related variables, providing evidence for a central assumption of the ART’s type-1 process. Furthermore, indirect methods seem to be suitable to assess automatic associations. The aim of the second publication (Schinkoeth, Weymar, & Brand, 2019) was to approach the somato-affective core of the automatic valuation of exercise using analysis of reactivity in vagal HRV while viewing exercise-related pictures. Results revealed that differences in exercise volume could be regressed on HRV reactivity. In light of the ART, these findings were interpreted as evidence of an inter-individual affective reaction elicited at the thought of exercise and triggered by exercise-stimuli. In the third publication (Schinkoeth & Brand, 2019, subm.), it was sought to disentangle and relate to each other the ART’s type-1 process components—automatic associations and the affective valuation of exercise. Automatic associations to exercise were assessed with a recoding-free variant of an implicit association test (IAT). Analysis of HRV reactivity was applied to approach a somatic component of the affective valuation, and facial reactions in a facial expression (FE) task served as indicators of the automatic affective reaction’s valence. Exercise behavior was assessed via self-report. The measurement of the affective valuation’s valence with the FE task did not work well in this study. HRV reactivity was predicted by the IAT score and did also statistically predict exercise behavior. These results thus confirm and expand upon the results of publication two and provide empirical evidence for the type-1 process, as defined in the ART. This dissertation advances the field of exercise psychology concerning the influence of automaticity and affect on exercise motivation. Moreover, both methodical implications and theoretical extensions for the ART can be derived from the results.

Dating of alluvial fans from NW Argentina using cosmogenic nuclides and optically stimulated luminescence technique (2018)

Reger, Carolin

Alluvial fans are important geomorphic markers and sedimentary archives of tectonic and climatic changes. Hence, basins providing perfect studying conditions can often be found in arid regions due to the low weathering impact and thus well preservation of sedimentary features. Twelve samples for optically/infrared stimulated luminescence (OSL/IRSL) dating and one depth profile for cosmogenic radionuclide dating (10Be) were collected in the Santa Maria Valley in NW Argentina, where the exceptional preservation of several generations of alluvial fans allow exploring the external forcing conditions that led to repeated cycles of incision and aggradation. The results of the OSL/IRSL dating yielded ages ranging between 0.4 ± 0.1 ka and 271.8 ± 24.5 ka. Previous studies next to the study area indicate a depositional age of 1.5-2 Mio years for the oldest generation of alluvial fans, which might still be supported by our ongoing 10Be dating. Due to field observations, sediment provenance, stratigraphic characteristics and the geomorphic pattern of erosion, seven (/eight) generations of alluvial fan deposits were recognized. Comparing my ages with global glaciation cycles as well as linking them to temperature proxies retrieved from a lake on the Altiplano Plateau, a good fit between alluvial fan accumulation phases and global glacial periods (corresponding to cold/wet phases within the central Andes) is observed. This suggests that aggradation occurs during the early stages of glacial periods, while incision is expected at the end of glacial phases. This pattern might be linked to variations in the vegetational cover (controlled by water availability), which will decrease/increase during hot and dry/cold and wet interglacial/glacial phases favoring/limiting sediment production and will increase/decrease during cold and wet/hot and dry glacial/interglacial phases. Even though the eastern Andean margin is showing neotectonic activities and is assumed to be active up to recent times, deformation and seismicity might most probably have played only a minor role in relation to the rather short timescale reflected by the data.

La carte de Tupaia, maître d'astres et de navigation polynésienne (2019)

Eckstein, Lars ; Schwarz, Anja

La carte de Tupaia constitue l’un des artéfacts les plus célèbres et les plus énigmatiques à émerger des toutes premières rencontres entre Européens et îliens du Pacifique. Elle a été élaborée entre août 1769 et février 1770 par Tupaia, prêtre ’arioi, conseiller royal et maître de navigation originaire de Ra’iātea, aux Îles Sous-le-Vent de la Société. En collaboration avec divers membres d’équipage de l’Endeavour de James Cook, en deux temps distincts de cartographie et trois ébauches. L’identité de bien des îles qui y figurent et la logique de leur agencement demeuraient jusqu’à présent des énigmes. En se fiant en partie à des pièces d’archives restées ignorées, nous proposons, dans ce long essai, une nouvelle compréhension de sa logique cartographique, une reconstitution détaillée de sa genèse et donc, pour la toute première fois, une lecture exhaustive. La carte de Tupaia n’illustre pas seulement la magnitude et la maîtrise de la navigation polynésienne, elle réalise aussi une remarquable synthèse représentationnelle de deux systèmes d’orientation très différents.

MenschenRechtsMagazin : Informationen | Meinungen | Analysen (2020)

Figari Layús, Rosario ; Mauer, Victor ; Petrossian, Gurgen ; Safferling, Christoph ; Semizoglu, Azim ; Switala, Leon Holger ; Wagner, Marlene ; Wolfsteller, René

Aus dem Inhalt: • Herausforderungen staatlicher Schutzprogramme für Menschenrechtsverteidiger*innen in Lateinamerika • Kopftuchverbote im privatrechtlichen Arbeitsverhältnis im Lichte des unionsrechtlichen Diskriminierungsschutzes • Bericht über die Tätigkeit des Menschenrechtsausschusses der Vereinten Nationen im Jahre 2019 – Teil I: Staatenberichte

Tanakh Ram: Translating the Hebrew Bible into Israeli (2019)

Holzman, Gitit ; Zuckermann, Ghil‘ad

The Ram Bible (Tanakh Ram) is a recently-published Bible edition printed in two columns: the right-hand column features the original biblical Hebrew text and the lefthand column features the translation of the Bible into a high-register literary Israeli (Reclaimed Hebrew). The Ram Bible edition has gained impressive academic and popular attention. This paper looks at differences between academics, teachers, students, media personalities and senior officials in the education system, regarding their attitude to the Ram Bible. Our study reveals that Bible teachers and students who make frequent use of this edition understand its contribution to comprehending the biblical language, stories, and ideas. Opponents of Ram Bible are typically administrators and theoretician scholars who advocate the importance of teaching the Bible but do not actually teach it themselves. We argue that the fundamental difference between biblical Hebrew and Israeli makes the Hebrew Bible incomprehensible to native Israeli speakers. We explain the advantages of employing tools such as the Ram Bible.

Translating Jewish Cemeteries in Morocco (2019)

Driver, Cory

This paper addresses issues of translating both words and rituals as Muslim cemetery keepers care for Jewish graves and recite traditional prayers for the dead in Morocco. Several issues of translation must be dealt with while considering these rare and disappearing practices. The first issue to be discussed is the translation of Hebrew inscriptions into French by cemetery keepers. One cemetery keeper in Meknes has tried to compile an exhaustive index of the names and dates represented on the gravestones under her care. The Muslim guard of the Jewish cemetery in Sefrou, on the other hand, has somewhat famously told visitors differing stories about his ability and willingness to pray the Kaddish over the graves of emigrated relatives who cannot return to mark an anniversary death. These practices provide the context for considering how the act of Muslims caring for Jewish graves creates linguistic and ritual translations of traditional Jewish ancestor care.

Radical Translation as Transvaluation (2019)

Schramm, Netta

Scholars of modern Jewish thought explore the hermeneutics of “translation” to describe the transference of concepts between discourses. I suggest a more radical approach – translation as transvaluation – is required. Eschewing modern tests of truth such as “the author would have accepted it” and “the author should have accepted it,” this radical form of translation is intentionally unfaithful to original meanings. However, it is not a reductionist reading or a liberating text. Instead, it is a persistent squabble depending on both source and translation for sustenance. Exploring this paradigm entails a review of three expositions of the Korah biblical narrative; three readings dedicated to keeping an eye on current events: (1) Tsene-rene (Prague, 1622), biblical prose; (2) Yaldei Yisrael Kodesh, (Tel Aviv, 1973), a secular Zionist reworking of Tsene-rene; and (3) The Jews are Coming (Israel, 2014–2017) a satirical television show.

Tewje in Deutschland (2019)

Coors, Maria

Drawing on the example of Sholem Aleichem’s Tevye the Dairyman, this article covers the history of Yiddish translation and publication in Germany in the 20th century.Following the paradigm of translation as a cultural practice, I demonstrate how the translation reflects aspects of Jewish-German cultural history, focussing on a mainly inner-Jewish identity discourse before the Shoah and a remembrance context after it. Whereas decisive differences and changes characterize 20th-century history in diachronic as well as synchronic respect, the article reflects also on continuities and parallels.

A Translator against Translation (2019)

Drori, Danielle

The Melits Yosher and the Audience for Early Modern Yiddish Literature (2019)

Faierstein, Morris M.

Benjamin, Rosenzweig, and the Babel Fish (2019)

Krah, Markus ; Thulin, Mirjam

Predicting the F(ab)-mediated effect of monoclonal antibodies in vivo by combining cell-level kinetic and pharmacokinetic modelling (2012)

Krippendorff, Ben-Fillippo ; Oyarzún, Diego A. ; Huisinga, Wilhelm

Cell-level kinetic models for therapeutically relevant processes increasingly benefit the early stages of drug development. Later stages of the drug development processes, however, rely on pharmacokinetic compartment models while cell-level dynamics are typically neglected. We here present a systematic approach to integrate cell-level kinetic models and pharmacokinetic compartment models. Incorporating target dynamics into pharmacokinetic models is especially useful for the development of therapeutic antibodies because their effect and pharmacokinetics are inherently interdependent. The approach is illustrated by analysing the F(ab)-mediated inhibitory effect of therapeutic antibodies targeting the epidermal growth factor receptor. We build a multi-level model for anti-EGFR antibodies by combining a systems biology model with in vitro determined parameters and a pharmacokinetic model based on in vivo pharmacokinetic data. Using this model, we investigated in silico the impact of biochemical properties of anti-EGFR antibodies on their F(ab)-mediated inhibitory effect. The multi-level model suggests that the F(ab)-mediated inhibitory effect saturates with increasing drug-receptor affinity, thereby limiting the impact of increasing antibody affinity on improving the effect. This indicates that observed differences in the therapeutic effects of high affinity antibodies in the market and in clinical development may result mainly from Fc-mediated indirect mechanisms such as antibody-dependent cell cytotoxicity.

Puumala hantavirus infections in bank vole populations (2017)

Reil, Daniela ; Rosenfeld, Ulrike M. ; Imholt, Christian ; Schmidt, Sabrina ; Ulrich, Rainer G. ; Eccard, Jana A. ; Jacob, Jens

Background In Europe, bank voles (Myodes glareolus) are widely distributed and can transmit Puumala virus (PUUV) to humans, which causes a mild to moderate form of haemorrhagic fever with renal syndrome, called nephropathia epidemica. Uncovering the link between host and virus dynamics can help to prevent human PUUV infections in the future. Bank voles were live trapped three times a year in 2010–2013 in three woodland plots in each of four regions in Germany. Bank vole population density was estimated and blood samples collected to detect PUUV specific antibodies. Results We demonstrated that fluctuation of PUUV seroprevalence is dependent not only on multi-annual but also on seasonal dynamics of rodent host abundance. Moreover, PUUV infection might affect host fitness, because seropositive individuals survived better from spring to summer than uninfected bank voles. Individual space use was independent of PUUV infections. Conclusions Our study provides robust estimations of relevant patterns and processes of the dynamics of PUUV and its rodent host in Central Europe, which are highly important for the future development of predictive models for human hantavirus infection risk.

Rolle von mPGES1-abhängig gebildetem Prostaglandin E2 bei der Ausbildung von Insulinresistenz und nicht-alkoholischer Fettlebererkrankung durch die Modulation der Funktion von Lebermakrophagen

Coleman Mac Gregor of Inneregny, Charles Dominic

Eine Störung des Leberstoffwechsels durch die Ausbildung einer Insulinresistenz kann zu Folgeerkrankungen wie der nicht alkoholischen Fettlebererkrankung (NAFLD) bis hin zur Steatohepatitis (NASH) und zur Entwicklung eines Diabetes Typ II führen. Am Krankheitsverlauf sind residente (Kupfferzellen) sowie infiltrierende Makrophagen beteiligt, die durch inflammatorische Stimuli aktiviert werden und zur Progression von Lebererkrankungen führen können. Im Rahmen dieser Arbeit wurde die Rolle von mPGES1-abhängig gebildetem Prostaglandin E2 (PGE2) an der Modulation von aktivierten Lebermakrophagen untersucht. Dazu wurden Kupfferzellen und Peritonealmakrophagen (als Modell für infiltrierende Makrophagen) aus Wildtyp und mPGES1-defizienten Mäusen isoliert. Beide Makrophagenpopulationen wurden in Zellkulturversuchen mit Lipopolysacchariden (LPS) aktiviert und auf ihre PGE2-Synthese, Genexpression und Sekretion von verschiedenen Cytokinen hin untersucht. Die beiden Makrophagenpopulationen unterschieden sich hinsichtlich der PGE2-Synthese bei mPGSE1-Defizienz. Während bei Peritonealmakrophagen die LPS-abhängige PGE2-Synthese bei Abwesenheit der mPGES1 fast vollständig reprimiert war, war bei Kupfferzellen nur eine 25%ige Abnahme zu verzeichnen. Die postulierte selbstverstärkende Rückkopplungsschleife von PGE2 im Hinblick auf seine eigene Synthese konnte in isolierten Peritonealmakrophagen, nicht jedoch in Kupfferzellen, bestätigt werden. In Kupfferzellen führte exogenes PGE2 ferner zu einer Repression von den pro-inflammatorischen Cytokinen TNFα und IL-1β und für endogenes PGE2 konnte in diesem Zelltyp kein Effekt festgestellt werden. In Peritonealmakrophagen konnte hingegen auch für endogenes PGE2 eine reprimierende Wirkung auf die Expression von TNFα beobachtet werden. Das ist eventuell auf eine höhere Sensitivität gegenüber PGE2 von Peritonealmakrophagen im Vergleich zu Kupfferzellen zurückzuführen. PGE2 wirkte unter den gewählten Versuchsbedingungen in vitro somit eher anti-inflammatorisch. Cholesterolkristalle induzierten in Kupfferzellen die Expression der PGE2-synthetisierenden Enzyme und verschiedener pro-inflammatorische Cytokine. Sie könnten somit zu einer Progression von NAFL zu NASH beitragen. Die Daten aus dieser Arbeit deuten darauf hin, dass PGE2 im Rahmen von entzündlichen Leberveränderungen eine eher protektive Wirkung im Hinblick auf die Progression von NAFLD und Insulinresistenz haben könnte.

Unter Verschluss (2020)

von den Driesch, Ellen

Knowledge Modeling and Description Language 3.0 (2020)

Gronau, Norbert

Electret properties of polypropylene with surface chemical modification and crystalline reconstruction (2020)

Wang, Jingwen

As one of the most-produced commodity polymers, polypropylene draws considerable scientific and commercial interest as an electret material. In the present thesis, the influence of the surface chemical modification and crystalline reconstruction on the electret properties of the polypropylene thin films will be discussed. The chemical treatment with orthophosphoric acid can significantly improve the surface charge stability of the polypropylene electrets by introducing phosphorus- and oxygen-containing structures onto the modified surface. The thermally stimulated discharge measurement and charge profiling by means of piezoelectrically generated pressure steps are used to investigate the electret behaviour. It is concluded that deep traps of limited number density are created during the treatment with inorganic chemicals. Hence, the improvement dramatically decreases when the surface-charge density is substantially higher than ±1.2×10^(-3) C·m^(-2). The newly formed traps also show a higher trapping energy for negative charges. The energetic distributions of the traps in the non-treated and chemically treated samples offer an insight regarding the surface and foreign-chemical dominance on the charge storage and transport in the polypropylene electrets. Additionally, different electret properties are observed on the polypropylene films with the spherulitic and transcrystalline structures. It indicates the dependence of the charge storage and transport on the crystallite and molecular orientations in the crystalline phase. In general, a more diverse crystalline growth in the spherulitic samples can result in a more complex energetic trap distribution, in comparison to that in a transcrystalline polypropylene. The double-layer transcrystalline polypropylene film with a crystalline interface in the middle can be obtained by crystallising the film in contact with rough moulding surfaces on both sides. A layer of heterocharges appears on each side of the interface in the double-layer transcrystalline polypropylene electrets after the thermal poling. However, there is no charge captured within the transcrystalline layers. The phenomenon reveals the importance of the crystalline interface in terms of creating traps with the higher activation energy in polypropylene. The present studies highlight the fact that even slight variations in the polypropylene film may lead to dramatic differences in its electret properties.

Städtebauliche Verträge zur Baulandbereitstellung (2019)

Grötz, Vera Katharina

The in vivo mechanics of the magnetotactic backbone as revealed by correlative FLIM-FRET and STED microscopy (2019)

Günther, Erika ; Klauß, André ; Toro-Nahuelpan, Mauricio ; Schüler, Dirk ; Hille, Carsten ; Faivre, Damien

Protein interaction and protein imaging strongly benefit from the advancements in time-resolved and superresolution fluorescence microscopic techniques. However, the techniques were typically applied separately and ex vivo because of technical challenges and the absence of suitable fluorescent protein pairs. Here, we show correlative in vivo fluorescence lifetime imaging microscopy Forster resonance energy transfer (FLIM-FRET) and stimulated emission depletion (STED) microscopy to unravel protein mechanics and structure in living cells. We use magnetotactic bacteria as a model system where two proteins, MamJ and MamK, are used to assemble magnetic particles called magnetosomes. The filament polymerizes out of MamK and the magnetosomes are connected via the linker MamJ. Our system reveals that bacterial filamentous structures are more fragile than the connection of biomineralized particles to this filament. More importantly, we anticipate the technique to find wide applicability for the study and quantification of biological processes in living cells and at high resolution.

Deutsch-jüdische Bibelwissenschaft

Die ,,Europäisch-jüdischen Studien" repräsentieren die interdisziplinär vernetzte Kompetenz des neuen ,,Zentrums Jüdische Studien Berlin-Brandenburg" (ZJS). Das Zentrum versammelt die wichtigsten Institutionen dieser Region, die sich mit Jüdischen Studien befassen - darunter die einschlägigen Universitäten und Einrichtungen in Berlin und Potsdam. Der interdisziplinäre Charakter der Reihe zielt insbesondere auf geschichts-, geistes- und kulturwissenschaftliche Ansätze sowie auf intellektuelle, politische und religiöse Grundfragen, die jüdisches Leben und Denken heute inspirieren und in der Vergangenheit beeinflusst haben. In den BEITRÄGEN werden exzellente Monographien und Sammelbändezum gesamten Themenspektrum Jüdischer Studien veröffentlicht. Die Reihe ist peer-reviewed. In den KONTROVERSEN werden grundlegende Debatten aufgenommen, die von zeitgenössischer und publizistischer Relevanz sind. Die Reihe ist peer-reviewed. In den EDITIONEN werden Werke herausragender jüdischer Autoren neu aufgelegt.

Semantics-based composition of EMBOSS services (2011)

Lamprecht, Anna-Lena ; Naujokat, Stefan ; Margaria, Tiziana ; Steffen, Bernhard

Background More than in other domains the heterogeneous services world in bioinformatics demands for a methodology to classify and relate resources in a both human and machine accessible manner. The Semantic Web, which is meant to address exactly this challenge, is currently one of the most ambitious projects in computer science. Collective efforts within the community have already led to a basis of standards for semantic service descriptions and meta-information. In combination with process synthesis and planning methods, such knowledge about types and services can facilitate the automatic composition of workflows for particular research questions. Results In this study we apply the synthesis methodology that is available in the Bio-jETI workflow management framework for the semantics-based composition of EMBOSS services. EMBOSS (European Molecular Biology Open Software Suite) is a collection of 350 tools (March 2010) for various sequence analysis tasks, and thus a rich source of services and types that imply comprehensive domain models for planning and synthesis approaches. We use and compare two different setups of our EMBOSS synthesis domain: 1) a manually defined domain setup where an intuitive, high-level, semantically meaningful nomenclature is applied to describe the input/output behavior of the single EMBOSS tools and their classifications, and 2) a domain setup where this information has been automatically derived from the EMBOSS Ajax Command Definition (ACD) files and the EMBRACE Data and Methods ontology (EDAM). Our experiments demonstrate that these domain models in combination with our synthesis methodology greatly simplify working with the large, heterogeneous, and hence manually intractable EMBOSS collection. However, they also show that with the information that can be derived from the (current) ACD files and EDAM ontology alone, some essential connections between services can not be recognized. Conclusions Our results show that adequate domain modeling requires to incorporate as much domain knowledge as possible, far beyond the mere technical aspects of the different types and services. Finding or defining semantically appropriate service and type descriptions is a difficult task, but the bioinformatics community appears to be on the right track towards a Life Science Semantic Web, which will eventually allow automatic service composition methods to unfold their full potential.

Kernresonanz-Strukturuntersuchungen an alternativen Precursoren und deren Zwischenprodukten für die Herstellung von Carbonfasern für den Massenmarkt (2019)

Bartel, Melanie

Carbonfasern haben sich in der Luft- und Raumfahrt etabliert und gewinnen in Alltagsanwendungen wie dem Automobilbereich, Windkraft- und Sportbereich durch ihre hohen Zugfestigkeiten, insbesondere ihrer hohen E-Moduli, und ihrer geringen Dichte immer mehr an Bedeutung. Auf Grund ihrer hohen Kosten, welche sich zur Hälfte aus der Precursorherstellung, inklusive seiner Synthese und seinem Verspinnprozess, dem Lösungsspinnverfahren, ergeben, erhalten zunehmend alternative und schmelzspinnbare Precursoren Interesse. Für die Carbonfaserherstellung wird fast ausschließlich Polyacrylnitril (PAN) verwendet, das vor dem Schmelzen irreversible exotherme Zyklisierungsreaktionen aufweist, welchen sich seine Zersetzung anschließt. Eine Möglichkeit der Reduzierung der Schmelztemperatur von Polymeren ist die Einbringung von Comonomeren zur Erhöhung des freien Volumens und die Reduzierung der intermolekularen Wechselwirkungen als interne Weichmacher. Wie am Fraunhofer IAP gezeigt wurde, kann mittels 2-Methoxyethylacrylat (MEA) die Schmelztemperatur zu neuartigen PAN-basierten Precursoren verringert werden. Um den PAN-co-MEA-Precursor für die nachfolgenden Prozessschritte der Carbonfaserherstellung zu verwenden, müssen die thermoplastischen Fasern in thermisch stabile Fasern ohne thermoplastisches Verhalten überführt werden. Es wurde ein neuer Prozessschritt (Prästabilisierung) eingeführt, welcher unter alkalischen Bedingungen zur Abspaltung der Comonomerseitenkette führt. Neben der Esterhydrolyse finden Reaktionen statt, welche an diesem Material noch nicht hinreichend untersucht wurden. Weiterhin stellt sich die Frage nach der Kinetik der Prästabilisierung und der Ermittlung einer geeigneten Prozessführung. Hierzu wurde die Prästabilisierung in den Labormaßstab überführt und die möglichen Zusammensetzungen des aus DMSO und einer KOH-Lösung bestehenden Reaktionsmediums evaluiert. Weiterhin wurde die Behandlung bei verschiedenen Prästabilisierungszeiten von maximal 30 min und Temperaturen von 40, 50 und 60 °C durchgeführt, um primär mittels NMR-Spektroskopie die chemischen Strukturänderungen aufzuklären. Die Esterhydrolyse des Comonomers, welche zur Abspaltung des 2-Methoxyethanols führt, wurde mittels 1H-NMR-spektroskopischer Untersuchungen detektiert. Es wurde ein Modell aufgestellt, das die chemisch-physikalischen Strukturänderungen während der Prästabilisierung aufzeigt. Die zuerst ablaufende Reaktion ist die Esterhydrolyse am Comonomer, welche vom Faserrand nach innen verläuft und durch die Präsenz des DMSO in Kombination mit der KOH-Lösung (Superbase) initiiert wird. Der zeitliche Reaktionsverlauf der Esterhydrolyse kann in drei Bereiche eingeteilt werden. Der erste Bereich ab dem Prästabilisierungsbeginn wird durch die Diffusion der basischen Anionen in die Faser, der zweite Bereich durch die Reaktion an der Estergruppe des Comonomers und der dritte Bereich durch letzte Reaktionen im Faserinneren und diffusiven Prozessen der Produkte und Edukte charakterisiert. Der zweite Bereich kann mit einer Reaktion pseudo 1. Ordnung abgebildet werden, da in diesem Bereich bereits eine ausreichende Diffusion der Edukte in die Faser stattgefunden hat. Bei 50 °C spielt die Diffusion im ersten Bereich im Vergleich zur Reaktion eine untergeordnete Rolle. Mit Erhöhung der Temperatur auf 60 °C kann eine im Verhältnis geringere Diffusions- als Reaktionsgeschwindigkeit beobachtet werden. Die Nebenreaktionen wurden mittels 13C-CP/MAS-NMR-spektroskopischen, elementaranlaytischen Untersuchungen sowie Doppelbrechungsmessungen charakterisiert. Während der alkalischen Esterhydrolyse beginnt die Reduzierung der Nitrilgruppen unter der Bildung von primären Carbonsäureamiden und Carbonsäuren. Zur Beschreibung dieser Umsetzung wurde eine Methode entwickelt, welche die Addition von 13C-CP/MAS-NMR-Spektren der Modellsubstanzen PAN, PAM und PAA beinhaltet. Weitere stattfindende Reaktionen sind die Bildung von konjugierten Doppelbindungen, welche insbesondere auf eine Zyklisierung der Nitrile hinweisen. Die nasschemisch initiierte Zyklisierung der Nitrilgruppen kann zu kürzeren Stabilisierungszeiten und einem besser kontrollierbaren Stabilisierungsprozess durch geringere Wärmefreisetzung und schlussendlich zu einer Kostenersparnis des gesamten Verfahrens führen. Die Umsetzung der Nitrilgruppen konnte mit einer Reaktion pseudo 1. Ordnung gut abgebildet werden. DMSO initiiert die Esterhydrolyse, wobei die KOH-Konzentration einen höheren Einfluss auf die Reaktionsgeschwindigkeit der Ester- und Nitrilhydrolyse als die DMSO-Konzentration besitzt. Beide Reaktionen zeigen eine vergleichbare Abhängigkeit von der Temperatur. Die Erhöhung der Prästabilisierungszeit und der KOH- bzw. DMSO-Konzentration führt zur Migration niedermolekularer Bestandteile des Fasermaterials an die Oberfläche und der Bildung punktueller Ablagerungen bis hin zu miteinander verbundenen Einzelfasern. Eine weitere Erhöhung der Prästabilisierungszeit bzw. der Konzentration führt zu einem steigenden Carbonsäureanteil und zur Quellung des Fasermaterials, wodurch die Ablagerungen in das Reaktionsmedium diffundieren. Die Ablagerungen enthalten Chlor, welches durch den Waschvorgang mit HCl in das Materialsystem gelangt ist und durch Parameteranpassungen reduziert wurde. Die schmelzbaren Fasern konnten durch die Prästabilisierung erfolgreich über eine Kern-Mantel-Struktur in nicht-thermoplastische Fasern überführt werden. Zur Ermittlung eines geeigneten Prozessfensters für nachfolgende thermische Beanspruchungen der prästabilisierten Fasern wurden drei Kriterien identifiziert, anhand welcher die Evaluation erfolgte. Das erste Kriterium beinhaltet die Notwendigkeit der vollständigen Aufhebung der thermoplastischen Eigenschaft der Fasern. Als zweites Kriterium diente die Fasermorphologie. Anhand von REM-Aufnahmen wurden Faserbündel mit separierten Einzelfasern ohne Ablagerungen für die nachfolgende Stabilisierung ausgewählt. Das dritte Kriterium bezieht sich auf eine möglichst geringe Umsetzung der Nitrilgruppen, um Prästabilisierungsbedingungen mit Nebenreaktionen zu vermeiden. Aus den Untersuchungen konnte eine Prästabilisierungstemperatur von 60 °C als geeignet identifiziert werden. Weiterhin führen hoch alkalische Zusammensetzungen des Reaktionsmediums mit KOH-Konzentrationen von 1, 1,5 und 2 M, vorzugsweise 1,5 M und 50 vol% DMSO mit Reaktionszeiten von unter 10 min zu geeigneten Fasern. Ein MEA-Anteil unterhalb von 2 mol% bewirkt eine Überführung in die Unschmelzbarkeit. Thermisch stabile und für die nachfolgende Stabilisierung geeignete Fasern besitzen weiterhin 68 – 80 mol% Nitrilgruppen, 20 – 25 mol% Carbonsäuren, bis zu 15 mol% primäre Carbonsäureamide und zyklisierte Strukturen.

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Fuchs, Stefanie

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