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Der Band versammelt verschiedenen Beiträge, die sich mit dem Leben und Werk von Peter Weiss auseinandersetzen. Die Beiträge wurden auf der Konferenz "Peter Weiss - 100" anläßlich des hundertsten Geburtstages des Autors im Jahre 2016 in Potsdam gehalten. Dabei wirkten unterschiedliche Einrichtungen und Institutionen erstmals gemeinsam im Geburtsort des Künstlers.
Aus dem Inhalt dieser Ausgabe: BEITRAG: Brigitte Rath: Zur Repräsentation von Gewalt MUSEEN: Gerhard Bauer: Das Militärwesen der frühen Neuzeit und seine Darstellung in der Dauerausstellung des Militärhistorischen Museums der Bundeswehr in Dresden Gerhard Quaas: Militaria-Sammlung 1: Alte Waffen und Rüstungen Manfried Rauchensteiner: Das Heeresgeschichtliche Museum als Gedächtnisort Christoph Rehm: Das Wehrgeschichtliche Museum Rastatt PROJEKTE: Uwe Tresp: Söldner aus Böhmen. Entstehung und Organisation böhmischer Södnerheere im Dienst deutscher Fürsten des 15. Jahrhunderts Matthias Franz: Die Rekrutierung der sächsischen Regimenter in der Niederlausitz 1726-1781 Olaf Gründel: Zum Verhältnis von Militär- und Zivilbevölkerung in brandenburgischen Städten des 18. Jahrhunderts. Das Beispiel Prenzlau Stephan Huck: Soldaten in Amerika. Sozialgeschichtliche Studie Braunschweiger Truppen im amerikanischen Unabhängigkeitskrieg Marc Schweska: Figuren der Vorstellung. Problematisierung von Macht und Moral in der Frühen Neuzeit Alexander Schunka: Fremde in Sachsen - ein Teilprojekt des Sonderforschungsbereichs "Pluralisierung und Autorität in der Frühen Neuzeit" Olaf Simons: Pierre Marteau's Verlagshaus sucht Kooperationspartner, Beiträge, Ideen für eine Web-Site zum Thema Europas Kriege 1670-1730 REZENSIONEN: Ulrike Ludwig: Rezensionen im Bulletin Militär und Gesellschaft in der Frühen Neuzeit Thomas Fuchs: Militär und ländliche Gesellschaft in der frühen Neuzeit, hrsg. von Stefan Kroll und Kersten Krüger, Hamburg 2000 Daniel Krebs: Stephan Brumwell, Redcoats. The British Soldier and War in the Americas, 1755-1763, Cambridge 2002 Heiner Lang: Claudia Brink, Arte et Marte, München 2000
Dielectric elastomer transducers consist of thin electrically insulating elastomeric membranes coated on both sides with compliant electrodes. They are a promising electromechanically active polymer technology that may be used for actuators, strain sensors, and electrical generators that harvest mechanical energy. The rapid development of this field calls for the first standards, collecting guidelines on how to assess and compare the performance of materials and devices. This paper addresses this need, presenting standardized methods for material characterisation, device testing and performance measurement. These proposed standards are intended to have a general scope and a broad applicability to different material types and device configurations. Nevertheless, they also intentionally exclude some aspects where knowledge and/or consensus in the literature were deemed to be insufficient. This is a sign of a young and vital field, whose research development is expected to benefit from this effort towards standardisation.
Computational drug sensitivity models have the potential to improve therapeutic outcomes by identifying targeted drug components that are likely to achieve the highest efficacy for a cancer cell line at hand at a therapeutic dose. State of the art drug sensitivity models use regression techniques to predict the inhibitory concentration of a drug for a tumor cell line. This regression objective is not directly aligned with either of these principal goals of drug sensitivity models: We argue that drug sensitivity modeling should be seen as a ranking problem with an optimization criterion that quantifies a drug's inhibitory capacity for the cancer cell line at hand relative to its toxicity for healthy cells. We derive an extension to the well-established drug sensitivity regression model PaccMann that employs a ranking loss and focuses on the ratio of inhibitory concentration and therapeutic dosage range. We find that the ranking extension significantly enhances the model's capability to identify the most effective anticancer drugs for unseen tumor cell profiles based in on in-vitro data.
Large-scale literature mining to assess the relation between anti-cancer drugs and cancer types
(2021)
Background:
There is a huge body of scientific literature describing the relation between tumor types and anti-cancer drugs. The vast amount of scientific literature makes it impossible for researchers and physicians to extract all relevant information manually.
Methods:
In order to cope with the large amount of literature we applied an automated text mining approach to assess the relations between 30 most frequent cancer types and 270 anti-cancer drugs. We applied two different approaches, a classical text mining based on named entity recognition and an AI-based approach employing word embeddings. The consistency of literature mining results was validated with 3 independent methods: first, using data from FDA approvals, second, using experimentally measured IC-50 cell line data and third, using clinical patient survival data.
Results:
We demonstrated that the automated text mining was able to successfully assess the relation between cancer types and anti-cancer drugs. All validation methods showed a good correspondence between the results from literature mining and independent confirmatory approaches. The relation between most frequent cancer types and drugs employed for their treatment were visualized in a large heatmap. All results are accessible in an interactive web-based knowledge base using the following link: .
Conclusions:
Our approach is able to assess the relations between compounds and cancer types in an automated manner. Both, cancer types and compounds could be grouped into different clusters. Researchers can use the interactive knowledge base to inspect the presented results and follow their own research questions, for example the identification of novel indication areas for known drugs.
Genossenschaften wirken auf manche wie ein angestaubtes Relikt aus der Vergangenheit. Das eingetrübte Image überrascht. Denn Genossenschaften haben sich immer wieder als besonders krisenfest erwiesen und längst auch als erfolgreiches Zukunftsmodell entpuppt. Der stetige Zuwachs an Neugründungen, die steigenden Mitgliederzahlen und die ständige Ausweitung der Aktionsfelder bestätigen die hohe Attraktivität. Dem entspricht eine enorme Einsatzbreite der Genossenschaftsidee. Sie reicht von Agrargenossenschaften über Produktionsgenossenschaften in Handel, Handwerk und Gewerbe bis hin zu sehr modernen Bereichen etwa der neuen Informations- und Kommunikationstechnologien. In all diesen und vielen anderen Segmenten finden sich variantenreiche genossenschaftliche Gestaltungsoptionen nach Maximen wie Selbsthilfe, Solidarität, Bürgerengagement, Partizipation, Mitglieder- und Gemeinwohlorientierung. Inzwischen lockt die hohe Anziehungskraft der Genossenschaftsidee auch die Kommunen. Angestoßen durch gesetzgeberische Impulse erleben die Genossenschaften auf der kommunalen Ebene derzeit bundesweit einen richtigen Aufschwung. Die Aufwertung erweitert die Überlegungen zur Gewährleistung und Optimierung kommunaler Leistungserbringung um eine wichtige Gestaltungsvariante, nimmt aber den Kommunen die Auswahlentscheidung nicht ab. Denn wie bei allen Organisationsentscheidungen ist vor dem Rückgriff auf genossenschaftliche Organisationsformen in jedem Einzelfall eine nüchterne aufgaben-, sach- und situationsbezogene Vergleichsanalyse geboten, die den Entscheidungsträgern spezifische Kenntnisse und detaillierte Fachkompetenz abverlangt. Die 19. Fachtagung des KWI diskutiert rechtliche Rahmenbedingungen und normative Direktiven, praktische Erfahrungen, Einsatzfelder, Erfolgsbedingungen und Fallstricke in der Praxis.
Despite increasing empirical evidence of strong links between climate and economic growth, there is no established model to describe the dynamics of how different types of climate shocks affect growth patterns. Here we present the first comprehensive, comparative analysis of the long-term dynamics of one-time, temporary climate shocks on production factors, and factor productivity, respectively, in a Ramsey-type growth model. Damages acting directly on production factors allow us to study dynamic effects on factor allocation, savings and economic growth. We find that the persistence of impacts on economic activity is smallest for climate shocks directly impacting output, and successively increases for direct damages on capital, loss of labor and productivity shocks, related to different responses in savings rates and factor-specific growth. Recurring shocks lead to large welfare effects and long-term growth effects, directly linked to the persistence of individual shocks. Endogenous savings and shock anticipation both have adaptive effects but do not eliminate differences between impact channels or significantly lower the dissipation time. Accounting for endogenous growth mechanisms increases the effects. We also find strong effects on income shares, important for distributional implications. This work fosters conceptual understanding of impact dynamics in growth models, opening options for links to empirics.
Ambitious climate policies, as well as economic development, education, technological progress and less resource-intensive lifestyles, are crucial elements for progress towards the UN Sustainable Development Goals (SDGs). However, using an integrated modelling framework covering 56 indicators or proxies across all 17 SDGs, we show that they are insufficient to reach the targets. An additional sustainable development package, including international climate finance, progressive redistribution of carbon pricing revenues, sufficient and healthy nutrition and improved access to modern energy, enables a more comprehensive sustainable development pathway. We quantify climate and SDG outcomes, showing that these interventions substantially boost progress towards many aspects of the UN Agenda 2030 and simultaneously facilitate reaching ambitious climate targets. Nonetheless, several important gaps remain; for example, with respect to the eradication of extreme poverty (180 million people remaining in 2030). These gaps can be closed by 2050 for many SDGs while also respecting the 1.5 °C target and several other planetary boundaries.
Many universities record the lectures being held in their facilities to preserve knowledge and to make it available to their students and, at least for some universities and classes, to the broad public. The way with the least effort is to record the whole lecture, which in our case usually is 90 min long. This saves the labor and time of cutting and rearranging lectures scenes to provide short learning videos as known from Massive Open Online Courses (MOOCs), etc. Many lecturers fear that recording their lectures and providing them via an online platform might lead to less participation in the actual lecture. Also, many teachers fear that the lecture recordings are not used with the same focus and dedication as lectures in a lecture hall. In this work, we show that in our experience, full lectures have an average watching duration of just a few minutes and explain the reasons for that and why, in most cases, teachers do not have to worry about that.