Nonscanning large-area Raman imaging for ex vivo/in vivo skin cancer discrimination
- Imaging Raman spectroscopy can be used to identify cancerous tissue. Traditionally, a step-by-step scanning of the sample is applied to generate a Raman image, which, however, is too slow for routine examination of patients. By transferring the technique of integral field spectroscopy (IFS) from astronomy to Raman imaging, it becomes possible to record entire Raman images quickly within a single exposure, without the need for a tedious scanning procedure. An IFS-based Raman imaging setup is presented, which is capable of measuring skin ex vivo or in vivo. It is demonstrated how Raman images of healthy and cancerous skin biopsies were recorded and analyzed. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
| Author details: | Elmar Gerd SchmälzlinGND, Benito Moralejo, Ingo Gersonde, Johannes SchleusenerGND, Maxim E. Darvin, Gisela ThiedeGND, Martin M. RothORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1117/1.JBO.23.10.105001 |
| ISSN: | 1083-3668 |
| ISSN: | 1560-2281 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30288965 |
| Title of parent work (English): | Journal of biomedical optics |
| Publisher: | SPIE |
| Place of publishing: | Bellingham |
| Publication type: | Article |
| Language: | English |
| Date of first publication: | 2018/10/04 |
| Publication year: | 2018 |
| Release date: | 2021/09/17 |
| Tag: | Raman imaging; Raman spectroscopy; astronomy; cancer diagnosis; dermis; epidermis; multichannel |
| Volume: | 23 |
| Issue: | 10 |
| Number of pages: | 11 |
| Funding institution: | German Federal Ministry of Education and Research (BMBF) VIP program, "Multiplex-Raman-Spektroskopie" (MRS) [03V0843] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik und Astronomie |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik |
| Peer review: | Referiert |
| Publishing method: | Open Access / Gold Open-Access |
| DOAJ gelistet | |
| License (English): |  Creative Commons - Namensnennung 3.0 Unported |
