Junzhong Liu, Lili Feng, Xueting Gu, Xian Deng, Qi Qiu, Qun Li, Yingying Zhang, Muyang Wang, Yiwen Deng, Ertao Wang, Yuke He, Isabel Bäurle, Jianming Li, Xiaofeng Cao, Zuhua He
- Global warming has profound effects on plant growth and fitness. Plants have evolved sophisticated epigenetic machinery to respond quickly to heat, and exhibit transgenerational memory of the heat-induced release of post-transcriptional gene silencing (PTGS). However, how thermomemory is transmitted to progeny and the physiological relevance are elusive. Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2 (HSFA2) directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6 (REF6), which in turn derepresses HSFA2. REF6 and HSFA2 establish a heritable feedback loop, and activate an E3 ubiquitin ligase, SUPPRESSOR OF GENE SILENCING 3 (SGS3)-INTERACTING PROTEIN 1 (SGIP1). SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA (tasiRNA). The REF6-HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5 (HTT5), which drives early flowering but attenuates immunity. Thus, heat induces transmitted phenotypes via a coordinated epigenetic network involving histoneGlobal warming has profound effects on plant growth and fitness. Plants have evolved sophisticated epigenetic machinery to respond quickly to heat, and exhibit transgenerational memory of the heat-induced release of post-transcriptional gene silencing (PTGS). However, how thermomemory is transmitted to progeny and the physiological relevance are elusive. Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2 (HSFA2) directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6 (REF6), which in turn derepresses HSFA2. REF6 and HSFA2 establish a heritable feedback loop, and activate an E3 ubiquitin ligase, SUPPRESSOR OF GENE SILENCING 3 (SGS3)-INTERACTING PROTEIN 1 (SGIP1). SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA (tasiRNA). The REF6-HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5 (HTT5), which drives early flowering but attenuates immunity. Thus, heat induces transmitted phenotypes via a coordinated epigenetic network involving histone demethylases, transcription factors, and tasiRNAs, ensuring reproductive success and transgenerational stress adaptation.…
MetadatenAuthor details: | Junzhong Liu, Lili Feng, Xueting Gu, Xian Deng, Qi Qiu, Qun Li, Yingying Zhang, Muyang WangORCiD, Yiwen Deng, Ertao WangORCiD, Yuke HeORCiD, Isabel BäurleORCiDGND, Jianming LiORCiD, Xiaofeng Cao, Zuhua He |
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DOI: | https://doi.org/10.1038/s41422-019-0145-8 |
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ISSN: | 1001-0602 |
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ISSN: | 1748-7838 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30778176 |
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Title of parent work (English): | Cell research |
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Publisher: | Nature Publ. Group |
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Place of publishing: | London |
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Publication type: | Article |
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Language: | English |
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Date of first publication: | 2019/02/18 |
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Publication year: | 2019 |
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Release date: | 2021/02/26 |
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Tag: | Chromatin; Epigenetic memory; Epigenetics; Innate immunity; Plant signalling |
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Volume: | 29 |
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Issue: | 5 |
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Number of pages: | 12 |
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First page: | 379 |
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Last Page: | 390 |
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Funding institution: | National Natural Science Foundation of ChinaNational Natural Science Foundation of China [91640114, 31330061, 31788103, 91540203, 31600207, 31770323]; Chinese Academy of SciencesChinese Academy of Sciences [XDB27040201, QYZDY-SSW-SMC022]; National Key Laboratory of Plant Molecular Genetics, the China Postdoctoral Science Foundation [2016M590386]; State Key Laboratory of Plant Genomics, the China Postdoctoral Science Foundation [2016M590386]; Youth Innovation Promotion Association of CAS [2018131] |
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Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
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DDC classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
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Peer review: | Referiert |
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Publishing method: | Open Access / Hybrid Open-Access |
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License (German): | CC-BY - Namensnennung 4.0 International |
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