The MADS-box transcription factor PHERES1 controls imprinting in the endosperm by binding to domesticated transposons
- MADS-box transcription factors (TFs) are ubiquitous in eukaryotic organisms and play major roles during plant development. Nevertheless, their function in seed development remains largely unknown. Here, we show that the imprinted Arabidopsis thaliana MADS-box TF PHERES1 (PHE1) is a master regulator of paternally expressed imprinted genes, as well as of non-imprinted key regulators of endosperm development. PHE1 binding sites show distinct epigenetic modifications on maternal and paternal alleles, correlating with parental-specific transcriptional activity. Importantly, we show that the CArG-box-like DNA-binding motifs that are bound by PHE1 have been distributed by RC/Helitron transposable elements. Our data provide an example of the molecular domestication of these elements which, by distributing PHE1 binding sites throughout the genome, have facilitated the recruitment of crucial endosperm regulators into a single transcriptional network.
Verfasserangaben: | Rita A. Batista, Jordi Moreno-RomeroORCiD, Yichun Qiu, Joram van Boven, Juan Santos-Gonzalez, Duarte Dionisio FigueiredoORCiDGND, Claudia KöhlerORCiD |
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DOI: | https://doi.org/10.7554/eLife.50541 |
ISSN: | 2050-084X |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/31789592 |
Titel des übergeordneten Werks (Englisch): | eLife |
Verlag: | eLife Sciences Publications |
Verlagsort: | Cambridge |
Publikationstyp: | Wissenschaftlicher Artikel |
Sprache: | Englisch |
Jahr der Erstveröffentlichung: | 2019 |
Erscheinungsjahr: | 2019 |
Datum der Freischaltung: | 18.09.2020 |
Band: | 8 |
Seitenanzahl: | 29 |
Fördernde Institution: | Vetenskapsrdet; Knut och Alice Wallenbergs StiftelseKnut & Alice Medical Research |
Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
Peer Review: | Referiert |
Publikationsweg: | Open Access |
Open Access / Gold Open-Access | |
DOAJ gelistet |