Strong as a hippo’s heart
- The heart is comprised of multiple tissues that contribute to its physiological functions. During development, the growth of myocardium and endocardium is coupled and morphogenetic processes within these separate tissue layers are integrated. Here, we discuss the roles of mechanosensitive Hippo signaling in growth and morphogenesis of the zebrafish heart. Hippo signaling is involved in defining numbers of cardiac progenitor cells derived from the secondary heart field, in restricting the growth of the epicardium, and in guiding trabeculation and outflow tract formation. Recent work also shows that myocardial chamber dimensions serve as a blueprint for Hippo signaling-dependent growth of the endocardium. Evidently, Hippo pathway components act at the crossroads of various signaling pathways involved in embryonic zebrafish heart development. Elucidating how biomechanical Hippo signaling guides heart morphogenesis has direct implications for our understanding of cardiac physiology and pathophysiology.
Author details: | Dorothee BornhorstORCiDGND, Salim SeyfriedORCiDGND |
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DOI: | https://doi.org/10.3389/fcell.2021.731101 |
ISSN: | 2296-634X |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/34422841 |
Title of parent work (English): | Frontiers in cell and developmental biology |
Subtitle (English): | Biomechanical hippo signaling during zebrafish cardiac development |
Publisher: | Frontiers Media |
Place of publishing: | Lausanne, Schweiz |
Further contributing person(s): | Andrea Erika Münsterberg, Katherine Yutzey, Thomas Brand |
Publication type: | Article |
Language: | English |
Date of first publication: | 2021/08/05 |
Publication year: | 2021 |
Release date: | 2022/04/28 |
Tag: | Hippo signaling; Yap1/Wwtr1 (Taz); cardiac development; endocardium; intra-organ-communication; mechanobiology; myocardium; zebrafish |
Volume: | 9 |
Article number: | 731101 |
Number of pages: | 10 |
First page: | 1 |
Last Page: | 10 |
Funding institution: | German National Academy of Sciences Leopoldina project LPDS |
Funding institution: | Deutsche Forschungsgemeinschaft (DFG) German Research Foundation (DFG) |
Funding institution: | Open Access Publishing Fund of University of Potsdam |
Funding number: | 2021-01 |
Funding number: | SFB958, SE2016/13-1 |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
Extern / Extern | |
DDC classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Peer review: | Referiert |
Grantor: | Publikationsfonds der Universität Potsdam |
Publishing method: | Open Access / Gold Open-Access |
DOAJ gelistet | |
License (German): | CC-BY - Namensnennung 4.0 International |
External remark: | Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe ; 1236 |