Nonscanning large-area Raman imaging for ex vivo/in vivo skin cancer discrimination
- Imaging Raman spectroscopy can be used to identify cancerous tissue. Traditionally, a step-by-step scanning of the sample is applied to generate a Raman image, which, however, is too slow for routine examination of patients. By transferring the technique of integral field spectroscopy (IFS) from astronomy to Raman imaging, it becomes possible to record entire Raman images quickly within a single exposure, without the need for a tedious scanning procedure. An IFS-based Raman imaging setup is presented, which is capable of measuring skin ex vivo or in vivo. It is demonstrated how Raman images of healthy and cancerous skin biopsies were recorded and analyzed. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
| Verfasserangaben: | Elmar Gerd SchmälzlinGND, Benito Moralejo, Ingo Gersonde, Johannes SchleusenerGND, Maxim E. Darvin, Gisela ThiedeGND, Martin M. RothORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1117/1.JBO.23.10.105001 |
| ISSN: | 1083-3668 |
| ISSN: | 1560-2281 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30288965 |
| Titel des übergeordneten Werks (Englisch): | Journal of biomedical optics |
| Verlag: | SPIE |
| Verlagsort: | Bellingham |
| Publikationstyp: | Wissenschaftlicher Artikel |
| Sprache: | Englisch |
| Datum der Erstveröffentlichung: | 04.10.2018 |
| Erscheinungsjahr: | 2018 |
| Datum der Freischaltung: | 17.09.2021 |
| Freies Schlagwort / Tag: | Raman imaging; Raman spectroscopy; astronomy; cancer diagnosis; dermis; epidermis; multichannel |
| Band: | 23 |
| Ausgabe: | 10 |
| Seitenanzahl: | 11 |
| Fördernde Institution: | German Federal Ministry of Education and Research (BMBF) VIP program, "Multiplex-Raman-Spektroskopie" (MRS) [03V0843] |
| Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik und Astronomie |
| DDC-Klassifikation: | 5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik |
| Peer Review: | Referiert |
| Publikationsweg: | Open Access / Gold Open-Access |
| DOAJ gelistet | |
| Lizenz (Englisch): |  Creative Commons - Namensnennung 3.0 Unported |
