Extern
Refine
Year of publication
Document Type
- Article (193) (remove)
Is part of the Bibliography
- yes (193) (remove)
Keywords
- football (5)
- Reflexion (4)
- exercise (4)
- Lehrkräftebildung (3)
- kinetics (3)
- obesity (3)
- stunting (3)
- COVID-19 (2)
- Feedback (2)
- Physical activity (2)
- SEPE (2)
- SNARC (2)
- Summer Schools (2)
- achilles tendinopathy (2)
- attention (2)
- body height (2)
- climate change (2)
- diabetes (2)
- diffusion (2)
- electromyography (2)
- handgrip strength (2)
- health care (2)
- language acquisition (2)
- literature review (2)
- longitudinal (2)
- machine learning (2)
- malnutrition (2)
- maturation (2)
- pre-school (2)
- reflexion (2)
- school mathematics (2)
- skills (2)
- virtual reality (2)
- wheat (2)
- 3D thermal model (1)
- 5-methoxycarbonylmethyl-2-thiouridine (1)
- ACWR (1)
- AFLP (1)
- ALOS World 3D (1)
- APP (1)
- ASTER GDEM (1)
- Adipose tissue (1)
- Adolescents (1)
- Adult-child interaction (1)
- Advection and convection (1)
- Aftercare (1)
- Aging (1)
- Akan (1)
- Akt pathway (1)
- Animal personality (1)
- Anthropologie (1)
- Arabica coffee (1)
- Arabidopsis thaliana (1)
- Bacteria (1)
- Barriers (1)
- Bayesian modelling (1)
- Biomarker (1)
- Brandenburg (1)
- CDOM (1)
- COVID-19 pandemic (1)
- CRISPR editing validation (1)
- Central European Basin System (1)
- Chew Bahir (1)
- Chlamydomonas (1)
- Chronic conditions (1)
- Chronic low back pain (1)
- Cognitive fatigue (1)
- Conversation Analysis (1)
- Copernicus DEM (1)
- Coping (1)
- Cross-frequency PLV (1)
- Cystic fibrosis (1)
- Cytochrome b (1)
- DEM noise (1)
- Damage assessment (1)
- Data pooling (1)
- Delphi study (1)
- Developmental hyperscanning (1)
- Digital Health (1)
- Digital intervention (1)
- Digitalisierung (1)
- Disturbance impacts (1)
- Disturbance indicator (1)
- Dual EEG analysis (1)
- Dynamometry (1)
- EEG (1)
- Eating behavior (1)
- Eccentric muscle action (1)
- Electronic Health (1)
- Elephant disturbance (1)
- Embodied cognition (1)
- Energy expenditure (1)
- Erkenntnisgewinnung (1)
- European hare (1)
- Exertion (1)
- Feature selection (1)
- FieldTrip (1)
- Fluorescence (1)
- Forschungsmethodik (1)
- Forschungsorientierung (1)
- Fortbildung (1)
- Fourier analysis (1)
- Fresh water fish (1)
- GPS (1)
- Gait (1)
- Gene expression (1)
- Genetics (1)
- Geothermal field (1)
- Germany (1)
- Glucose homeostasis (1)
- Governance (1)
- Grip force (1)
- H2S biosynthesis (1)
- HDL (1)
- HIV (1)
- Hamstring-quadriceps ratio (1)
- Handlungsempfehlungen (1)
- Health insurance (1)
- Heat transport by conduction (1)
- Hippo signaling (1)
- Human physical conditioning (1)
- ICDP (1)
- Individualized therapy (1)
- Injury (1)
- Injury risk (1)
- Inklusion (1)
- Insulin resistance (1)
- Inter-individual differences (1)
- Interactional Linguistics (1)
- Internet of Things (1)
- Interoception (1)
- Intuitive eating (1)
- Iron Age (1)
- Irradiation (1)
- Island biogeography (1)
- Jurkat cells (1)
- Just so stories (1)
- Juvenile idiopathic arthritis (1)
- KI-Anwendung (1)
- Klimapolitik (1)
- Kommune (1)
- Künstliche Intelligenz (1)
- K−12 teachers (1)
- LC-MS/MS (1)
- LC/HRMS (1)
- LCSM (1)
- LC–MS/MS (1)
- LDL (1)
- Lake Holzmaar (1)
- Lake Malawi (1)
- Lehramtsstudium Biologie (1)
- Levy walks (1)
- Locally structured correlation (1)
- Locally structured standard deviation (1)
- M1/M2 differentiation (1)
- MALDI-TOF-MS (1)
- MCI (1)
- MSAP (1)
- Mandarin-English bilinguals (1)
- Martial arts (1)
- Maschinelles Lernen (1)
- Matthew effect (1)
- Mental number line (1)
- Metabolic syndrome (1)
- MiSpEx (1)
- MiSpEx-network (1)
- Microtus arvalis (1)
- Mindfulness (1)
- Mitochondria (1)
- Mixed methods (1)
- Mobile Health (1)
- Mobile diagnostics (1)
- Moco biosynthesis (1)
- Monte Carlo method (1)
- Monte-Carlo simulation (1)
- Motor system (1)
- Movement (1)
- Movement ecology (1)
- Muscle strength (1)
- Musculoskeletal and neural physiological phenomena (1)
- N400 (1)
- NAFLD/MAFLD (1)
- Natural Language Processing (1)
- Non-invasive vagus nerve stimulation (1)
- Noradrenaline (1)
- Number processing (1)
- NutriAct Family Study (1)
- Nutrition (1)
- ODBA (1)
- Obesity (1)
- Older adults (1)
- Omicron (1)
- Ontologie (1)
- Overhead athletes (1)
- PLV (1)
- Partial Little Square (1)
- Partnership (1)
- Phase Locking Value (1)
- Philosophie (1)
- Photodynamics (1)
- Phylogeny (1)
- Physical training (1)
- Pipistrellus nathusii (1)
- Plyometric exercise (1)
- Postural control (1)
- Potsdam (1)
- Prevention (1)
- Prior knowledge (1)
- Professionalisierung (1)
- Professionswissen (1)
- Prospective (1)
- Protective factors (1)
- Quality of life (1)
- Quantitative Trait Locus (1)
- Quantitative Trait Locus analysis (1)
- Randomized controlled trial (1)
- Randomized-controlled trial (1)
- Referendariat (1)
- Reflexivität (1)
- Rehabilitation (1)
- Repetition (1)
- Reproducible benchmarking (1)
- Resiliency (1)
- Resistance training (1)
- Rotifera (1)
- Rural health (1)
- SARS-CoV-2 (1)
- SEPE Factors (1)
- SEPS factors (1)
- SFON (1)
- SRT (1)
- SRTM (1)
- Sammelband (1)
- Sedimentary basin (1)
- Selbstreflexion (1)
- Seminarkonzept (1)
- Shire River (1)
- Shoulder (1)
- Social-Economic-Political-Emotional (SEPE) factors (1)
- South-Eastern Africa (1)
- Soziale Medien (1)
- Specific wood density (1)
- Sport-specific performance (1)
- St. Nicolas House Analysis (1)
- Stadt (1)
- Standard deviation (1)
- Statistical Exercise (1)
- Stress response (1)
- Studienabbruch (1)
- Studieneingang (1)
- Studienerfolg (1)
- Sway (1)
- TAVI (1)
- TLR signaling (1)
- TMAO reductase (1)
- TMS (1)
- Tagung (1)
- TanDEM-X (1)
- Telehealth (1)
- Telemedicine (1)
- Theodor W. Adorno (1)
- Tiredness (1)
- Transformation (1)
- Tree allometry (1)
- Twitter (1)
- Type 1 diabetes (1)
- Ulmener Maar Tephra (1)
- Ulrich Sonnemann (1)
- Union (1)
- Unterrichtsanalyse (1)
- Unterrichtsmethoden (1)
- VR (1)
- Variance (1)
- Vignetten (1)
- Wearable electronic device (1)
- Wearable technology (1)
- Wirkungsforschung (1)
- Wood specific gravity (1)
- Woody aboveground biomass (1)
- WorldDEM (1)
- X-ray (1)
- Yamal (1)
- Yap1/Wwtr1 (Taz) (1)
- accelerometer (1)
- acclimation (1)
- acid mine drainage (1)
- acoustic communication (1)
- acyclic diene metathesis (ADMET) polymerization (1)
- adaptive management (1)
- addition (1)
- adipose tissue (1)
- adolescents (1)
- advanced dynamic flow (1)
- aerobic power (1)
- aggression (1)
- aging (1)
- agricultural landscape (1)
- allocation policies (1)
- alpha-2 (1)
- amino acids (1)
- animal migration (1)
- animal personality (1)
- anomalous diffusion (1)
- anterior PNP (1)
- anterior cruciate ligament (1)
- anthropology (1)
- anthropometry (1)
- anti-cancer drugs (1)
- antibody (1)
- antidepressants (1)
- apoptosis (1)
- application of artificial intelligence (1)
- approximate methods (1)
- arable weeds (1)
- artificial intelligence (1)
- asymptotic method (1)
- athletes (1)
- athletic performance (1)
- augmented reality (1)
- automated radio telemetry (1)
- balance (1)
- baroclinicity (1)
- basic need satisfaction and frustration (1)
- bats (1)
- behavior problems (1)
- behavioral and self-report measures (1)
- behavioral type (1)
- behaviour (1)
- bibliometric analysis (1)
- biodiversity conservation (1)
- biological age (1)
- biology (1)
- biomechanics (1)
- birth weight (1)
- bis-MGD (1)
- blockchain (1)
- body mass index (1)
- body proportions (1)
- bound phenolic compounds (1)
- brain health (1)
- breastfeeding (1)
- buffer zones (1)
- burnout (1)
- business process management (1)
- business processes (1)
- cTBS (1)
- callous-unemotional traits (1)
- callousness (1)
- camelid antibody (1)
- camelid heavy-chain-only antibodies (1)
- capabilities (1)
- carbon cycling (1)
- cardiac catheterization (CC) (1)
- cardiac development (1)
- cardiology (1)
- cardiomyopathy (1)
- cardiovascular diseases (1)
- catch-up-growth (1)
- cellular bioenergetics (1)
- cellulose polymeric organic matter (1)
- central and peripheral vision (1)
- cereal leaf beetle (1)
- change of direction speed (1)
- changepoint analysis (1)
- changepoint detection (1)
- chaperone (1)
- child growth (1)
- children and adolescents (1)
- chimera (1)
- cholesterol (1)
- chronic health condition (1)
- chronic undernutrition (1)
- citation analysis (1)
- climate change adaptation (1)
- climate policy (1)
- clinical sample (1)
- coffee processing (1)
- cognitive bias (1)
- cognitive/muscular fatigue (1)
- collegial casework (1)
- color (1)
- community model (1)
- composition (1)
- constraint (1)
- consultation (1)
- content knowledge (1)
- continuing education activities (1)
- copy number analyses (1)
- corpus dataset (1)
- cost optimisation (1)
- counting (1)
- creativity (1)
- cross-species capture (1)
- cyberaggression (1)
- cytosine methylation (1)
- cytosolic tRNA thiolation (1)
- daily home-made measurements (1)
- deep neural networks (1)
- deferred choice (1)
- dental eruption (1)
- depressive disorder (1)
- depressive symptoms (1)
- derivational complexity (1)
- design of experiment (1)
- design thinking (1)
- development (1)
- diabetes mellitus (1)
- diabetic (1)
- digital technologies (1)
- digital transformation (1)
- digitalization (1)
- diketopiperazine (1)
- disaster risk reduction (1)
- discrepancy principle (1)
- disorder recognition (1)
- distress (1)
- drought events (1)
- drought intensity (1)
- drought projections (1)
- drug delivery (1)
- drug-sensitivity prediction (1)
- eavesdropping (1)
- eccentric-plyometric (1)
- echolocation (1)
- economy (1)
- ecophysiology (1)
- ecosystem restoration (1)
- education (1)
- eicosanoids (1)
- elderly (1)
- electrochemistry (1)
- elevated plus-maze (1)
- elf-determination theory (1)
- embodied cognition (1)
- emergency management (1)
- emotional regulation (1)
- emotional stress (1)
- endocardium (1)
- endophytes (1)
- energy expenditure (1)
- energy policy (1)
- enhancement (1)
- entropy (1)
- environmental pollution (1)
- erythropoiesis (1)
- europe (1)
- european (1)
- everyday life (1)
- exercise cognition (1)
- exercise test (1)
- exercise training (1)
- external load (1)
- extracellular enzymes (1)
- extremophiles (1)
- eye movements (1)
- fear (1)
- feature selection (1)
- federated learning (1)
- feedback (1)
- feeling of presence (1)
- fence ecology (1)
- fiction (1)
- finite-size effects (1)
- first-passage time (1)
- first-reaction time (1)
- fitness (1)
- flexibility (1)
- floods (1)
- food access (1)
- food web (1)
- formal semantics (1)
- fractionation (1)
- frailty tool (1)
- frame index (1)
- frames of reference (1)
- freshwater (1)
- frustration (1)
- functional performance (1)
- functional traits (1)
- fungal pathogens (1)
- fungi (1)
- gait (1)
- games (1)
- genome scan (1)
- global change (1)
- governance (1)
- graphs (1)
- ground reaction forces (1)
- growth references (1)
- growth standards (1)
- growth tempo (1)
- guideline (1)
- happiness (1)
- healthcare (1)
- heart rate (1)
- heavy-chain-only antibody (1)
- height in history (1)
- heliozoa (1)
- herbivory (1)
- high density lipoprotein cholesterol (1)
- high-sodium (1)
- hippocampal-prefrontal network (1)
- historical growth (1)
- home range (1)
- homologous recombination deficiency (1)
- homology-directed repair (1)
- hospitalization (1)
- human excised skin (1)
- human physical conditioning (1)
- hybridization capture (1)
- hydrolysis (1)
- iPhone (1)
- imaginary world (1)
- implicit learning (1)
- in-service training (1)
- inclusive education (1)
- injury risk (1)
- innovation laboratories (1)
- inquiry (1)
- insulin (1)
- insulin resistance (1)
- integration (1)
- intellectual ability (1)
- intelligence (1)
- intergroup contacts (1)
- internal load (1)
- intonation units (1)
- intra-organ-communication (1)
- intraguild predation (1)
- ion-exchange chromatography (1)
- kelp (1)
- kinematics (1)
- knots (1)
- kollegiale Fallbesprechung (1)
- lake catchments (1)
- lakes (1)
- landscape transience (1)
- language courses (1)
- linear enamel hypoplasia (1)
- linear sprint (1)
- lipid peroxidation (1)
- lipids (1)
- local governance (1)
- locus coeruleus (1)
- lokale Governance (1)
- long-term effects (1)
- low back pain (1)
- low density lipoprotein cholesterol (1)
- low-back-pain (1)
- macrostructure (1)
- magnitude estimation (1)
- major depressive disorder (1)
- math (1)
- mathematical development (1)
- mathematical precursor (1)
- mcgraph (1)
- measurement (1)
- mechanobiology (1)
- mental health (1)
- mental imagery (1)
- mental number line (1)
- mental simulation (1)
- meta-science (1)
- metabolic disease (1)
- metathesis (1)
- meteorological drought (1)
- methods (1)
- miRNA (1)
- miRNAs (1)
- microfacies (1)
- microplastics (1)
- microstructure (1)
- migrants (1)
- migration (1)
- mild cognitive impairment (1)
- mindfulness-based stress reduction (1)
- mini growth spurt (1)
- mining lakes (1)
- mitochondrial adaptation (1)
- molecular species identification (1)
- molecular weaving (1)
- molybdenum cofactor (1)
- monensin (1)
- mortality (1)
- motor-control-exercise (1)
- movement (1)
- multidisciplinary intervention (1)
- multidisciplinary-therapy (1)
- multiple modalities (1)
- muscle metabolism (1)
- muscle strength (1)
- musculoskeletal and neural physiological phenomena (1)
- museum specimens (1)
- myocardium (1)
- nanobodies (1)
- nanogels (1)
- narrative (1)
- narrative skills (1)
- natural language processing (1)
- natural particle (1)
- nature of science (1)
- need profiles (1)
- neovascularization (1)
- network reconstruction (1)
- networks (1)
- neurological disorders (1)
- neuromuscular (1)
- neutralization (1)
- non-adjacent dependencies (1)
- nonlinear operator (1)
- novel biomarkers (1)
- nucleic acids (1)
- number knowledge (1)
- numerical development (1)
- numerical skills (1)
- nutrition (1)
- nutritional status (1)
- object search (1)
- older patients (1)
- oncology (1)
- ontology (1)
- open-field (1)
- optimal rate (1)
- oracles (1)
- oxidative stress (1)
- oxygen consumption (1)
- pace of life (1)
- paleoclimate (1)
- pandemic (1)
- parentage (1)
- past biosphere (1)
- peak height velocity (1)
- pedagogical content knowledge (PCK) (1)
- pedagogical reasoning (1)
- peptide biomarkers (1)
- performance (1)
- performance evaluation (1)
- periodic entanglement (1)
- permafrost (1)
- philosophy (1)
- phonetics (1)
- phonotaxis (1)
- photoresponse (1)
- photosynthesis (1)
- physical fitness (1)
- physical time (1)
- physiology (1)
- playback (1)
- plyometric exercise (1)
- policy recommendations (1)
- political ideology (1)
- polyenoic fatty acids (1)
- post-natal (1)
- posterior P600 (1)
- pre-natal (1)
- pre-service teacher (1)
- precaution (1)
- precuneus (1)
- predictability (1)
- predictive models (1)
- preschool children (1)
- preschoolers (1)
- prevention (1)
- priming (1)
- privacy and security (1)
- privacy attack (1)
- probabilistic processing (1)
- problem solving (1)
- professional development (1)
- professional knowledge (1)
- professionalization (1)
- prosocial (1)
- prosody (1)
- protein modification (1)
- psycho-oncology (1)
- psychoeducation (1)
- psychopathology (1)
- psychophysiological (1)
- psychotherapy process (1)
- pubertal timing (1)
- public health (1)
- pupil diameter (1)
- purification (1)
- quality (1)
- questioning solutions (1)
- random sampling (1)
- recombinant inbred line (1)
- redox state (1)
- refined consensus model (RCM) (1)
- refugees (1)
- regularization (1)
- regulation of growth (1)
- remote sensing data (1)
- remote teaching (1)
- renewable energy (1)
- repetition (1)
- reproductive success (1)
- research design (1)
- resistance training (1)
- resource-tracking (1)
- response inhibition (1)
- response styles theory (1)
- response time (1)
- resting-state fMRI (1)
- return-to-sport (1)
- reversed-phase chromatography (1)
- review (1)
- rheumatic diseases (1)
- risk management (1)
- role-play (1)
- rotifer (1)
- rule learning (1)
- rumination (1)
- runners (1)
- running mechanics (1)
- rural (1)
- sAA (1)
- scene memorization (1)
- scene viewing (1)
- science teaching (1)
- secular changes (1)
- sedaDNA (1)
- sedentary (1)
- sediment core (1)
- selenite (1)
- self-control (1)
- seminar concept (1)
- sensitivity (1)
- serial reaction time (SRT) task (1)
- shared leadership (1)
- shell-like geometries (1)
- short-term growth (1)
- signal propagation (1)
- single case analysis (1)
- single domain antibodies (1)
- single-case design (1)
- single-case experimental design (1)
- skeletal age (1)
- skin penetration (1)
- smart contracts (1)
- social class (1)
- social environment (1)
- social network (1)
- social status insecurity (1)
- socioeconomy (1)
- solitary bees (1)
- soliton (1)
- sonography (1)
- source-to-sink (1)
- spatial autocorrelation (1)
- spatial frequencies (1)
- spatial language (1)
- spatial updating (1)
- spatially explicit (1)
- special education (1)
- speech (1)
- speed (1)
- sport-specific performance (1)
- sports (1)
- stability (1)
- standardized patient (1)
- standardized patient information (1)
- standards (1)
- standing long jump (1)
- starch granule (1)
- starch granule morphology (1)
- starch granule size (1)
- starch metabolism (1)
- step-growth polymerization (1)
- stochastic resetting (1)
- storm tracks (1)
- stratigraphy (1)
- stress (1)
- stress intervention (1)
- stress management (1)
- striking combat sports (1)
- structural equation model (1)
- study designs (1)
- study protocol (1)
- subtraction (1)
- sulfite oxidase (1)
- sustainability (1)
- syntax (1)
- tVNS (1)
- tacrolimus formulation (1)
- taekwondo electronic scoring system (1)
- taekwondo-specific testing (1)
- talk-in-interaction (1)
- tangles (1)
- target capture (1)
- teacher learning (1)
- teacher quality (1)
- teacher training (1)
- teaching education (1)
- teaching practice (1)
- tendinosis (1)
- therapist competence (1)
- theta (1)
- time-efficient exercise (1)
- toxicity (1)
- training (1)
- training adaptation (1)
- transformation (1)
- transformation products (1)
- translation (1)
- treatment integrity (1)
- triglycerides (1)
- type 2 diabetes (1)
- type specimens (1)
- ultrasound (1)
- uncaring (1)
- unemotional (1)
- ungulate (1)
- usability (1)
- varves (1)
- veterinary cordon fence (1)
- veterinary drugs (1)
- vicious cycle (1)
- vignettes (1)
- virus infection (1)
- voice (1)
- water sports (1)
- web-based (1)
- wh-ex-situ (1)
- wh-in-situ (1)
- wh-questions (1)
- wildlife and habitat management (1)
- workflow patterns (1)
- working memory (1)
- yellow flags (1)
- youth soccer (1)
- youth sport (1)
- youth sports (1)
- zebrafish (1)
- zweite Ausbildungsphase (1)
- α-amylase/trypsin inhibitors (1)
- „Natur der Naturwissenschaften“ (1)
- social network analysis (1)
- team creativity (1)
- intrapreneurship (1)
Institute
- Extern (193) (remove)
Intelligence, as well as working memory and attention, affect the acquisition of mathematical competencies. This paper aimed to examine the influence of working memory and attention when taking different mathematical skills into account as a function of children’s intellectual ability. Overall, intelligence, working memory, attention and numerical skills were assessed twice in 1868 German pre-school children (t1, t2) and again at 2nd grade (t3). We defined three intellectual ability groups based on the results of intellectual assessment at t1 and t2. Group comparisons revealed significant differences between the three intellectual ability groups. Over time, children with low intellectual ability showed the lowest achievement in domain-general and numerical and mathematical skills compared to children of average intellectual ability. The highest achievement on the aforementioned variables was found for children of high intellectual ability. Additionally, path modelling revealed that, depending on the intellectual ability, different models of varying complexity could be generated. These models differed with regard to the relevance of the predictors (t2) and the future mathematical skills (t3). Causes and conclusions of these findings are discussed.
In this paper we examine the effect of uncertainty on readers’ predictions about meaning. In particular, we were interested in how uncertainty might influence the likelihood of committing to a specific sentence meaning. We conducted two event-related potential (ERP) experiments using particle verbs such as turn down and manipulated uncertainty by constraining the context such that readers could be either highly certain about the identity of a distant verb particle, such as turn the bed […] down, or less certain due to competing particles, such as turn the music […] up/down. The study was conducted in German, where verb particles appear clause-finally and may be separated from the verb by a large amount of material. We hypothesised that this separation would encourage readers to predict the particle, and that high certainty would make prediction of a specific particle more likely than lower certainty. If a specific particle was predicted, this would reflect a strong commitment to sentence meaning that should incur a higher processing cost if the prediction is wrong. If a specific particle was less likely to be predicted, commitment should be weaker and the processing cost of a wrong prediction lower. If true, this could suggest that uncertainty discourages predictions via an unacceptable cost-benefit ratio. However, given the clear predictions made by the literature, it was surprisingly unclear whether the uncertainty manipulation affected the two ERP components studied, the N400 and the PNP. Bayes factor analyses showed that evidence for our a priori hypothesised effect sizes was inconclusive, although there was decisive evidence against a priori hypothesised effect sizes larger than 1μV for the N400 and larger than 3μV for the PNP. We attribute the inconclusive finding to the properties of verb-particle dependencies that differ from the verb-noun dependencies in which the N400 and PNP are often studied.
Injuries in professional soccer are a significant concern for teams, and they are caused amongst others by high training load. This cohort study describes the relationship between workload parameters and the occurrence of non-contact injuries, during weeks with high and low workload in professional soccer players throughout the season. Twenty-one professional soccer players aged 28.3 ± 3.9 yrs. who competed in the Iranian Persian Gulf Pro League participated in this 48-week study. The external load was monitored using global positioning system (GPS, GPSPORTS Systems Pty Ltd) and the type of injury was documented daily by the team's medical staff. Odds ratio (OR) and relative risk (RR) were calculated for non-contact injuries for high- and low-load weeks according to acute (AW), chronic (CW), acute to chronic workload ratio (ACWR), and AW variation (Δ-Acute) values. By using Poisson distribution, the interval between previous and new injuries were estimated. Overall, 12 non-contact injuries occurred during high load and 9 during low load weeks. Based on the variables ACWR and Δ-AW, there was a significantly increased risk of sustaining non-contact injuries (p < 0.05) during high-load weeks for ACWR (OR: 4.67), and Δ-AW (OR: 4.07). Finally, the expected time between injuries was significantly shorter in high load weeks for ACWR [1.25 vs. 3.33, rate ratio time (RRT)] and Δ-AW (1.33 vs. 3.45, RRT) respectively, compared to low load weeks. The risk of sustaining injuries was significantly larger during high workload weeks for ACWR, and Δ-AW compared with low workload weeks. The observed high OR in high load weeks indicate that there is a significant relationship between workload and occurrence of non-contact injuries. The predicted time to new injuries is shorter in high load weeks compared to low load weeks. Therefore, the frequency of injuries is higher during high load weeks for ACWR and Δ-AW. ACWR and Δ-AW appear to be good indicators for estimating the injury risk, and the time interval between injuries.
In order to improve a recently established cell-based assay to assess the potency of botulinum neurotoxin, neuroblastoma-derived SiMa cells and induced pluripotent stem-cells (iPSC) were modified to incorporate the coding sequence of a reporter luciferase into a genetic safe harbor utilizing CRISPR/Cas9. A novel method, the double-control quantitative copy number PCR (dc-qcnPCR), was developed to detect off-target integrations of donor DNA. The donor DNA insertion success rate and targeted insertion success rate were analyzed in clones of each cell type. The dc-qcnPCR reliably quantified the copy number in both cell lines. The probability of incorrect donor DNA integration was significantly increased in SiMa cells in comparison to the iPSCs. This can possibly be explained by the lower bundled relative gene expression of a number of double-strand repair genes (BRCA1, DNA2, EXO1, MCPH1, MRE11, and RAD51) in SiMa clones than in iPSC clones. The dc-qcnPCR offers an efficient and cost-effective method to detect off-target CRISPR/Cas9-induced donor DNA integrations.
The role of the GMP nucleotides of the bis-molybdopterin guanine dinucleotide (bis-MGD) cofactor of the DMSO reductase family has long been a subject of discussion. The recent characterization of the bis-molybdopterin (bis-Mo-MPT) cofactor present in the E. coli YdhV protein, which differs from bis-MGD solely by the absence of the nucleotides, now enables studying the role of the nucleotides of bis-MGD and bis-MPT cofactors in Moco insertion and the activity of molybdoenzymes in direct comparison. Using the well-known E. coli TMAO reductase TorA as a model enzyme for cofactor insertion, we were able to show that the GMP nucleotides of bis-MGD are crucial for the insertion of the bis-MGD cofactor into apo-TorA.
The intake of high-fat diets (HFDs) containing large amounts of saturated long-chain fatty acids leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium, as a crucial part of antioxidative selenoproteins, can protect against the development of diet-induced insulin resistance in white adipose tissue (WAT) by increasing glutathione peroxidase 3 (GPx3) and insulin receptor (IR) expression. Whether selenite (Se) can attenuate insulin resistance in established lipotoxic and obese conditions is unclear. We confirm that GPX3 mRNA expression in adipose tissue correlates with BMI in humans. Cultivating 3T3-L1 pre-adipocytes in palmitate-containing medium followed by Se treatment attenuates insulin resistance with enhanced GPx3 and IR expression and adipocyte differentiation. However, feeding obese mice a selenium-enriched high-fat diet (SRHFD) only resulted in a modest increase in overall selenoprotein gene expression in WAT in mice with unaltered body weight development, glucose tolerance, and insulin resistance. While Se supplementation improved adipocyte morphology, it did not alter WAT insulin sensitivity. However, mice fed a SRHFD exhibited increased insulin content in the pancreas. Overall, while selenite protects against palmitate-induced insulin resistance in vitro, obesity impedes the effect of selenite on insulin action and adipose tissue metabolism in vivo.
The Covid-19 pandemic imposed new constraints on empirical research and forced researchers to transfer from traditional laboratory research to the online environment. This study tested the validity of a web-based episodic memory paradigm by comparing participants’ memory performance for trustworthy and untrustworthy facial stimuli in a supervised laboratory setting and an unsupervised web setting. Consistent with previous results, we observed enhanced episodic memory for untrustworthy compared to trustworthy faces. Most importantly, this memory bias was comparable in the online and the laboratory experiment, suggesting that web-based procedures are a promising tool for memory research.
Cognitive resources contribute to balance control. There is evidence that mental fatigue reduces cognitive resources and impairs balance performance, particularly in older adults and when balance tasks are complex, for example when trying to walk or stand while concurrently performing a secondary cognitive task.
We conducted a systematic literature search in PubMed (MEDLINE), Web of Science and Google Scholar to identify eligible studies and performed a random effects meta-analysis to quantify the effects of experimentally induced mental fatigue on balance performance in healthy adults. Subgroup analyses were computed for age (healthy young vs. healthy older adults) and balance task complexity (balance tasks with high complexity vs. balance tasks with low complexity) to examine the moderating effects of these factors on fatigue-mediated balance performance.
We identified 7 eligible studies with 9 study groups and 206 participants. Analysis revealed that performing a prolonged cognitive task had a small but significant effect (SMDwm = −0.38) on subsequent balance performance in healthy young and older adults. However, age- and task-related differences in balance responses to fatigue could not be confirmed statistically.
Overall, aggregation of the available literature indicates that mental fatigue generally reduces balance in healthy adults. However, interactions between cognitive resource reduction, aging and balance task complexity remain elusive.
How do different reset protocols affect ergodicity of a diffusion process in single-particle-tracking experiments? We here address the problem of resetting of an arbitrary stochastic anomalous-diffusion process (ADP) from the general mathematical points of view and assess ergodicity of such reset ADPs for an arbitrary resetting protocol. The process of stochastic resetting describes the events of the instantaneous restart of a particle’s motion via randomly distributed returns to a preset initial position (or a set of those). The waiting times of such resetting events obey the Poissonian, Gamma, or more generic distributions with specified conditions regarding the existence of moments. Within these general approaches, we derive general analytical results and support them by computer simulations for the behavior of the reset mean-squared displacement (MSD), the new reset increment-MSD (iMSD), and the mean reset time-averaged MSD (TAMSD). For parental nonreset ADPs with the MSD(t)∝ tμ we find a generic behavior and a switch of the short-time growth of the reset iMSD and mean reset TAMSDs from ∝ _μ for subdiffusive to ∝ _1 for superdiffusive reset ADPs. The critical condition for a reset ADP that recovers its ergodicity is found to be more general than that for the nonequilibrium stationary state, where obviously the iMSD and the mean TAMSD are equal. The consideration of the new statistical quantifier, the iMSD—as compared to the standard MSD—restores the ergodicity of an arbitrary reset ADP in all situations when the μth moment of the waiting-time distribution of resetting events is finite. Potential applications of these new resetting results are, inter alia, in the area of biophysical and soft-matter systems.