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Herzen, Aleksandr
(2001)
In soils of the Rustenbug Minig Area microorganism concentration and activity of several enzymes (dehydrogenase, phosphatase, protease, amylase, cellulase, xylanase) were determined. First results indicate an increase of heavy metal resistant Microorganisms and a possible inhibition of carbohydrate degrading enzymes.
Breton and Irish, two Celtic and strongly endangered European minority languages, enjoy (or suffer) different fates of official recognition. While France does not officially recognise Breton as an independent language and has no even signed the European Charter of Minority Languages as most other EU countries did, Irish is by its constitution the first national language of the Republic of Ireland and therefore enjoys a very high official prestige. It is an obligatory subject in the schools and all EU documents need to be translated both into Irish and English. In spite of this difference of status and prestige, both languages have suffered, during the past 50 years, from a dramatic loss of speakers, as the young generation sees no need to preserve a regionalised minority heritage in a world of globalised communication and exchange. While both inherited languages were, traditionally and sociologically speaking, the medium of communication of the rural population, albeit with a long and venerable written tradition reaching back to the middle ages, the language of the future is that of the urban middle classes learnt as a second language (L2) und for all intents and purposes not used as a community language in the home. Middle class Breton and Irish are token languages, serving its users as identity markers in order to set themselves off from the English and French, most of whom only speak English and French and have no additional regional language. The linguistic gap between the inherited rural and the new urban varieties is great, so that older native rural speakers do not understand school Breton and school Irish. It is predictable that only the urban varieties will survive for still quite a while, whereas the rural varietes are unlikely to escape language death due to the ongoing change of living conditions in the rural areas and the absence of localised language engineering.
Der Beitrag stellt Teilergebnisse zu Prozessen der Selbstregulation von Schülern mit geistiger Behinderung in den Mittelpunkt. Die Einzelfallanlyse erfolgt unter Kenntnis physiologischer Parameter der Selbstregulation im pädagogischen Kontext. Aspekte der chronopsychobiologischen Regulationsdiagnostik finden Einbindung in den Beitrag.
Krimi und Gesellschaft
(2001)
The factors that determine the efficiency of energy transfer in aquatic food webs have been investigated for many decades. The plant-animal interface is the most variable and least predictable of all levels in the food web. In order to study determinants of food quality in a large lake and to test the recently proposed central importance of the long-chained eicosapentaenoic acid (EPA) at the pelagic producer-grazer interface, we tested the importance of polyunsaturated fatty acids (PUFAs) at the pelagic producer-consumer interface by correlating sestonic food parameters with somatic growth rates of a clone of Daphnia galeata. Daphnia growth rates were obtained from standardized laboratory experiments spanning one season with Daphnia feeding on natural seston from Lake Constance, a large pre-alpine lake. Somatic growth rates were fitted to sestonic parameters by using a saturation function. A moderate amount of variation was explained when the model included the elemental parameters carbon (r2 = 0.6) and nitrogen (r2 = 0.71). A tighter fit was obtained when sestonic phosphorus was incorporated (r2 = 0.86). The nonlinear regression with EPA was relatively weak (r2 = 0.77), whereas the highest degree of variance was explained by three C18-PUFAs. The best (r2 = 0.95), and only significant, correlation of Daphnia's growth was found with the C18-PUFA a-linolenic acid (a-LA; C18:3n-3). This correlation was weakest in late August when C:P values increased to 300, suggesting that mineral and PUFA- limitation of Daphnia's growth changed seasonally. Sestonic phosphorus and some PUFAs showed not only tight correlations with growth, but also with sestonic alpha-LA content. We computed Monte Carlo simulations to test whether the observed effects of alpha-LA on growth could be accounted for by EPA, phosphorus, or one of the two C18-PUFAs, stearidonic acid (C18:4n-3) and linoleic acid (C18:2n-6). With >99% probability, the correlation of growth with alpha-LA could not be explained by any of these parameters. In order to test for EPA limitation of Daphnia's growth, in parallel with experiments on pure seston, growth was determined on seston supplemented with chemostat-grown, Plimited Stephanodiscus hantzschii, which is rich in EPA. Although supplementation increased the EPA content 80-800x, no significant changes in the nonlinear regression of the growth rates with alpha-LA were found, indicating that growth of Daphnia on pure seston was not EPA limited. This indicates that the two fatty acids, EPA and alpha-LA, were not mutually substitutable biochemical resources and points to different physiological functions of these two PUFAs. These results support the PUFA-limitation hypothesis for sestonic C:P < 300 but are contrary to the hypothesis of a general importance of EPA, since no evidence for EPA limitation was found. It is suggested that the resource ratios of EPA and alpha-LA rather than the absolute concentrations determine which of the two resources is limiting growth.
Bildung und Medien
(2001)
Deutsche reden Deutsch
(2001)
Brandt, K. (Hrsg.), Vor der Auslöschung : Fotografien gefunden in Auschwitz; München, Kehayoff, 2001
(2001)
DIW-Wochenbericht
(2001)
Kaddisch für das Röslein auf der Heide : über die Tragik der jüdisch-deutschen Volksliedseligkeit
(2001)
BACKGROUND: Dendritic cells (DC) as antigen presenting cells play an important role in immunotherapy of cancer. Mucin, encoded by the gene MUC1, is a human tumor antigen expressed in breast, pancreatic and ovarian cancers. Therefore, MUC1-transfected DC would be an attractive tool in constructing cancer vaccines. MATERIALS AND METHODS: Using two different cationic liposome preparations and, for comparison, a recombinant adenovirus expressing mucin, we tested the efficiency of mucin gene transfer into DC by flow cytometry. We investigated if these transfected DC were able to specifically stimulate autologous peripheral blood lymphocytes (PBL) from healthy donors. RESULTS: Flow cytometry revealed that 5-20% of DC transfected with liposomes Lipofectin and 20-40% of DC transduced with adenovirus expressed the relevant mucin epitopes. The expression of mucin on DC was similar to the expression of mucin found on carcinoma cells. After antigen uptake, DC specifically stimulated autologous PBL. CONCLUSION: We have shown that cationic liposomal gene transfer into human DC was feasible. We could obtain antigen specific stimulation of PBL at a similar rate as with adenoviral MUC1-transduced DC.
Tumor antigen-specific T cell clones represent a useful tool in tumor immunology; however, their long-term culture is limited. To generate an immortalized cytotoxic T cell clone against the human tumor antigen mucin, we exposed a previously generated T cell culture to Herpesvirus saimiri. We obtained an immortalized human CD4+ T cell clone, termed SITAM. Clonality of these cells was shown by analysis of the alpha/beta-T cell receptor (TCR) repertoire. Cytolytic activity was demonstrated against several mucin-expressing tumor cell lines and could not be detected against non-mucin-expressing cells. SITAM cells maintained their features stably for 2 years. Furthermore, growth of the tumor cell line Capan-2 in NOD/SCID mice was inhibited when SITAM cells were coinjected subcutaneously with tumor cells. SITAM cells provide an unlimited source of clonal T cells for analysis of tumor recognition and may be of help in TCR-targeted immunotherapy.
Over the last decade the modeling and the storage of biological data has been a topic of wide interest for scientists dealing with biological and biomedical research. Currently most data is still stored in text files which leads to data redundancies and file chaos. In this paper we show how to use relational modeling techniques and relational database technology for modeling and storing biological sequence data, i.e. for data maintained in collections like EMBL or SWISS-PROT to better serve the needs for these application domains. For this reason we propose a two step approach. First, we model the structure (and therefore the meaning of the) data using an Entity-Relationship approach. The ER model leads to a clean design of a relational database schema for storing and retrieving the DNA and protein data extracted from various sources. Our approach provides the clean basis for building complex biological applications that are more amenable to changes and software ports than their file-base counterparts.
Der Nationalsozialismus
(2001)
Diszipliniertes Geschlecht : Konturen von Disziplinarität un der Frauen- und Geschlechterforschung
(2001)
Zahlen, die Geschichte machen : die Zahl als Orientierungshilfe in der jüdischen Historiosophie
(2001)
Jüdische Mystik
(2001)
Klaus von Dohnanyi
(2001)
Hans Leussink
(2001)