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Enterprise Resource Planning (ERP) system customization is often necessary because companies have unique processes that provide their competitive advantage. Despite new technological advances such as cloud computing or model-driven development, technical ERP customization options are either outdated or ambiguously formulated in the scientific literature. Using a systematic literature review (SLR) that analyzes 137 definitions from 26 papers, the result is an analysis and aggregation of technical customization types by providing clearance and aligning with future organizational needs. The results show a shift from ERP code modification in on-premises systems to interface and integration customization in cloud ERP systems, as well as emerging technological opportunities as a way for customers and key users to perform system customization. The study contributes by providing a clear understanding of given customization types and assisting ERP users and vendors in making customization decisions.
Increasingly, research attention is being afforded to various forms of problematic media use. Despite ongoing conceptual, theoretical, and empirical debates, a large number of retrospective self-report scales have been produced to ostensibly measure various classes of such behaviour. These scales are typically based on a variety of theoretical and diagnostic frameworks. Given current conceptual ambiguities, building on previous studies, we evaluated the dimensional structure of 50 scales targeting the assessment of supposedly problematic behaviours in relation to four technologies: Internet, smartphones, video games, and social network sites. We find that two dimensions (‘compulsive use’ and ‘negative outcomes’) account for over 50% of all scale-items analysed. With a median of five dimensions, on average, scales have considered fewer dimensions than various proposed diagnostic criteria and models. No relationships were found between the number of items in a scale and the number of dimensions, or the technology category and the dimensional structure. The findings indicate, firstly, that a majority of scales place an inordinate emphasis on some dimensions over others and, secondly, that despite differences in the items presented, at a dimensional level, there exists a high degree of similarity between scales. These findings highlight shortcomings in existing scales and underscore the need to develop more sophisticated conceptions and empirical tools to understand possible problematic interactions with various digital technologies.
Does a smile open all doors?
(2020)
Online photographs govern an individual’s choices across a variety of contexts. In sharing arrangements, facial appearance has been shown to affect the desire to collaborate, interest to explore a listing, and even willingness to pay for a stay. Because of the ubiquity of online images and their influence on social attitudes, it seems crucial to be able to control these aspects. The present study examines the effect of different photographic self-disclosures on the provider’s perceptions and willingness to accept a potential co-sharer. The findings from our experiment in the accommodation-sharing context suggest social attraction mediates the effect of photographic self-disclosures on willingness to host. Implications of the results for IS research and practitioners are discussed.
During a crisis event, social media enables two-way communication and many-to-many information broadcasting, browsing others’ posts, publishing own content, and public commenting. These records can deliver valuable insights to approach problematic situations effectively. Our study explores how social media communication can be analyzed to understand the responses to health crises better. Results based on nearly 800 K tweets indicate that the coping and regulation foci framework holds good explanatory power, with four clusters salient in public reactions: 1) “Understanding” (problem-promotion); 2) “Action planning” (problem-prevention); 3) “Hope” (emotion-promotion) and 4) “Reassurance” (emotion-prevention). Second, the inter-temporal analysis shows high volatility of topic proportions and a shift from self-centered to community-centered topics during the course of the event. The insights are beneficial for research on crisis management and practicians who are interested in large-scale monitoring of their audience for well-informed decision-making.
Helping overcome distance, the use of videoconferencing tools has surged during the pandemic. To shed light on the consequences of videoconferencing at work, this study takes a granular look at the implications of the self-view feature for meeting outcomes. Building on self-awareness research and self-regulation theory, we argue that by heightening the state of self-awareness, self-view engagement depletes participants’ mental resources and thereby can undermine online meeting outcomes. Evaluation of our theoretical model on a sample of 179 employees reveals a nuanced picture. Self-view engagement while speaking and while listening is positively associated with self-awareness, which, in turn, is negatively associated with satisfaction with meeting process, perceived productivity, and meeting enjoyment. The criticality of the communication role is put forward: looking at self while listening to other attendees has a negative direct and indirect effect on meeting outcomes; however, looking at self while speaking produces equivocal effects.
Despite the phenomenal growth of Big Data Analytics in the last few years, little research is done to explicate the relationship between Big Data Analytics Capability (BDAC) and indirect strategic value derived from such digital capabilities. We attempt to address this gap by proposing a conceptual model of the BDAC - Innovation relationship using dynamic capability theory. The work expands on BDAC business value research and extends the nominal research done on BDAC – innovation. We focus on BDAC's relationship with different innovation objects, namely product, business process, and business model innovation, impacting all value chain activities. The insights gained will stimulate academic and practitioner interest in explicating strategic value generated from BDAC and serve as a framework for future research on the subject
Since the beginning of the recent global refugee crisis, researchers have been tackling many of its associated aspects, investigating how we can help to alleviate this crisis, in particular, using ICTs capabilities. In our research, we investigated the use of ICT solutions by refugees to foster the social inclusion process in the host community. To tackle this topic, we conducted thirteen interviews with Syrian refugees in Germany. Our findings reveal different ICT usages by refugees and how these contribute to feeling empowered. Moreover, we show the sources of empowerment for refugees that are gained by ICT use. Finally, we identified the two types of social inclusion benefits that were derived from empowerment sources. Our results provide practical implications to different stakeholders and decision-makers on how ICT usage can empower refugees, which can foster the social inclusion of refugees, and what should be considered to support them in their integration effort.
Background:
Childhood and adolescence are critical stages of life for mental health and well-being. Schools are a key setting for mental health promotion and illness prevention. One in five children and adolescents have a mental disorder, about half of mental disorders beginning before the age of 14. Beneficial and explainable artificial intelligence can replace current paper- based and online approaches to school mental health surveys. This can enhance data acquisition, interoperability, data driven analysis, trust and compliance. This paper presents a model for using chatbots for non-obtrusive data collection and supervised machine learning models for data analysis; and discusses ethical considerations pertaining to the use of these models.
Methods:
For data acquisition, the proposed model uses chatbots which interact with students. The conversation log acts as the source of raw data for the machine learning. Pre-processing of the data is automated by filtering for keywords and phrases.
Existing survey results, obtained through current paper-based data collection methods, are evaluated by domain experts (health professionals). These can be used to create a test dataset to validate the machine learning models. Supervised learning
can then be deployed to classify specific behaviour and mental health patterns.
Results:
We present a model that can be used to improve upon current paper-based data collection and manual data analysis methods. An open-source GitHub repository contains necessary tools and components of this model. Privacy is respected through
rigorous observance of confidentiality and data protection requirements. Critical reflection on these ethics and law aspects is included in the project.
Conclusions:
This model strengthens mental health surveillance in schools. The same tools and components could be applied to other public health data. Future extensions of this model could also incorporate unsupervised learning to find clusters and patterns
of unknown effects.
This article provides some insights into the complex relationships between thinking and behavioral patterns, bio graphical aspects and teaching style. The data was analyzed in the Grounded Theory tradition and with the help of ATLAS.ti. The results presented here offer preliminary findings only since the research is still ongoing. The focus is on the ways teachers deal with mistakes. Based on two case examples, it will be shown how the fear of making mistakes can lead to teacher-centered lessons, and thereby limiting pupils' possibilities to learn autonomously.
The “output-orientation” is omnipresent in teacher education. In order to evaluate teachers' and students' performances, a wide range of different quantitative questionnaires exist worldwide. One important goal of teaching evaluation is to increase the quality of teaching and learning. The author argues, that standard evaluations which are typically made at the end of the semester are problematic due to two reasons. The first one is that some of the questions are too general and don`t offer concrete ideas as to what kind of actions can be taken to make the courses better. The second problem is that the evaluation is mostly made when the course is already over. Because of this criticism, Apelojg invented the Felix-App which offers the possibility to give feedback in real-time by asking for the emotions and needs that occur during different learning situations. The idea is very simple: positive emotions and satisfied needs are helpful for the learning process. Negative emotions and unsatisfied needs have negative effects on the learning process. First descriptive results show, that “managing emotions” during classes can have positive effects on both motivation and emotions.
To date, sex and gender differences play only a minor role in medical research and practice, thereby putting individuals’ health at risk. Gender-specific medicine, or the practice of taking these differences into account when conducting research and treating patients so far is being discussed primarily by experts. With people increasingly using social media such as Twitter for sharing and searching for health-related information online, Twitter can potentially educate about gender-specific medicine. However, little is known about the information circulation and the structure of interactions on the Twitter network discussing this topic. Results of a network analysis show that the network exhibits a community-structure, with information exchange being limited and concentrated in silos. This indicates that there is untapped potential for acquiring new information by users through interacting with individuals outside their community. Public health officials may benefit from this insight and tailor online campaigns to enhance awareness on gender-specific medicine.
Living in a world of plenty?
(2020)
Inequality in the distribution of economic wealth within populations has been rising steadily over the past century, having reached unprecedented highs in many Western societies. However, this development is not reflected in people’s perceptions of wealth inequality, as the public tends to underestimate it. Research suggests that inequality estimates are derived from personal reference groups, which, as we propose, are expanded by social network site (SNS) use. As content on SNSs frequently revolves around events of consumption, signaling enhanced overall population wealth, this study tests the hypothesis that SNS use distorts inequality perceptions downward, i.e., increases the perception of societal equality. Responses of 534 survey participants in the United States confirm that SNS use negatively predicts perceived inequality. The relationship is stronger the more SNS users perceive the content they encounter online as real, supporting the assumption that observing other people’s behavior online lowers estimates of nationwide wealth inequality. These findings provide novel insights on inequality misperceptions by suggesting individuals’ SNS use as a new predictor of perceived wealth inequality.
Future ERP Systems
(2021)
This paper presents a research agenda on the current generation of ERP systems which was developed based on a literature review on current problems of ERP systems. The problems are presented following the ERP life cycle. In the next step, the identified problems are mapped on a reference architecture model of ERP systems that is an extension of the three-tier architecture model that is widely used in practice. The research agenda is structured according to the reference architecture model and addresses the problems identified regarding data, infrastructure, adaptation, processes, and user interface layer.
This systematic literature review highlights the gap in demand forecasting in the manufacturing sector, which is challenged by complex supply chains and rapid market change. Traditional methods fall short in this dynamic environment, highlighting the need for an approach that combines advanced forecasting techniques, high-quality data, and industry-specific insights. Our research contributes by evaluating advanced forecasting methods, the effectiveness of AI and data strategies to improve accuracy. Our analysis reveals a shift towards machine learning and deep learning to improve accuracy and highlights the untapped potential of external data sources. Key findings provide both researchers and practitioners with guidance on effective forecasting strategies and key data types and offer an integrated framework for improving forecasting accuracy and strategic decision-making in manufacturing. This work fills a critical research gap and provides stakeholders with actionable insights to manage the complexity of modern manufacturing, representing a significant advance in forecasting practice.
Track and Treat
(2018)
E-Mail tracking mechanisms gather information on individual recipients’ reading behavior. Previous studies show that e-mail newsletters commonly include tracking elements. However, prior work does not examine the degree to which e-mail senders actually employ gathered user information. The paper closes this research gap by means of an experimental study to clarify the use of tracking-based infor- mation. To that end, twelve mail accounts are created, each of which subscribes to a pre-defined set of newsletters from companies based in Germany, the UK, and the USA. Systematically varying e-mail reading patterns across accounts, each account simulates a different type of user with individual read- ing behavior. Assuming senders to track e-mail reading habits, we expect changes in mailer behavior. The analysis confirms the prominence of tracking in that over 92% of the newsletter e-mails contain tracking images. For 13 out of 44 senders an adjustment of communication policy in response to user reading behavior is observed. Observed effects include sending newsletters at different times, adapting advertised products to match the users’ IT environment, increased or decreased mailing frequency, and mobile-specific adjustments. Regarding legal issues, not all companies that adapt the mail-sending behavior state the usage of such mechanisms in their privacy policy.
E-Mail Tracking
(2016)
E-mail advertisement, as one instrument in the marketing mix, allows companies to collect fine-grained behavioural data about individual users’ e-mail reading habits realised through sophisticated tracking mechanisms. Such tracking can be harmful for user privacy and security. This problem is especially severe since e-mail tracking techniques gather data without user consent. Striving to increase privacy and security in e-mail communication, the paper makes three contributions. First, a large database of newsletter e-mails is developed. This data facilitates investigating the prevalence of e- mail tracking among 300 global enterprises from Germany, the United Kingdom and the United States. Second, countermeasures are developed for automatically identifying and blocking e-mail tracking mechanisms without impeding the user experience. The approach consists of identifying important tracking descriptors and creating a neural network-based detection model. Last, the effectiveness of the proposed approach is established by means of empirical experimentation. The results suggest a classification accuracy of 99.99%.
Coring on Digital Platforms
(2017)
Today’s mobile devices are part of powerful business ecosystems, which usually involve digital platforms. To better understand the complex phenomenon of coring and related dynamics, this paper presents a case study comparing iMessage as part of Apple’s iOS and WhatsApp. Specifically, it investigates activities regarding platform coring, as the integration of several functionalities provided by third-party applications in the platform core. The paper makes three contributions. First, a systematization of coring activities is developed. Coring modes are differentiated by the amount of coring and application maintenance. Second, the case study revealed that the phenomenon of platform coring is present on digital platforms for mobile devices. Third, the fundamentals of coring are discussed as a first step towards theoretical development. Even though coring constitutes a potential threat for third-party developers regarding their functional differentiation, an idea of what a beneficial partnership incorporating coring activities could look like is developed here.
Enterprise systems have long played an important role in businesses of various sizes. With the increasing complexity of today’s business relationships, specialized application systems are being used more and more. Moreover, emerging technologies such as artificial intelligence are becoming accessible for enterprise systems. This raises the question of the future role of enterprise systems. This minitrack covers novel ideas that contribute to and shape the future role of enterprise systems with five contributions.
While Information Systems (IS) Research on the individual and workgroup level of analysis is omnipresent, research on the enterprise-level IS is less frequent. Even though research on Enterprise Systems and their management is established in academic associations and conference programs, enterprise-level phenomena are underrepresented. This minitrack provides a forum to integrate existing research streams that traditionally needed to be attached to other topics (such as IS management or IS governance). The minitrack received broad attention. The three selected papers address different facets of the future role of enterprise-wide IS including aspects such as carbonization, ecosystem integration, and technology-organization fit.
The idea of the continuous improvement process (CIP) helps companies to continuously improve their operation and thereby contributes to their competitiveness. Through digi tization, new potentials emerge to solve known CIP issues. This contribution specifically addresses the individual motivation of employees to contribute to the CIP. Typically, related initiatives lack contributions over time. The use of gamification is a promising way to achieve continuous participation by addressing the individual needs of participants. While the use of extrinsic motivation elements is common in practice, the idea of this approach is to specifically address intrinsic motivations which serve as a long-term motivator. This article contributes to a gam-ification concept for the continuous improvement process. The main results include an adapted CIP, a gamification concept, and a market mechanism. Furthermore, the concept is implemented and demonstrated as a prototype in an online platform.
Die optimale Dimensionierung von IT-Hardware stellt Entscheider aufgrund der stetigen Weiterentwicklung zunehmend vor Herausforderungen. Dies gilt im Speziellen auch für Analytics-Infrastrukturen, die zunehmend auch neue Software zur Analyse von Daten einsetzen, welche in den Ressourcenanforderungen stark variieren. Damit eine flexible und gleichzeitig effiziente Gestaltung von Analytics-Infrastrukturen erreicht werden kann, wird ein dynamisch arbeitendes Architekturkonzept vorgeschlagen, das Aufgaben auf Basis einer systemspezifischen Entscheidungsmaxime mit Hilfe einer Eskalationsmatrix verteilt und hierfür Aufgabencharakteristiken sowie verfügbare Hardwareausstattungen entsprechend ihrer Auslastung berücksichtigt.
Software platforms allow for the extension of features by third-party contributors. Thereby, platform innovation is an important aspects of platforms attractiveness for users and complementors. While previous research focused the introduction of new features, the aspect of feature removal and discontinued features on software platforms has been disregarded. To explore the phenomenon and motivations for feature removal on software platforms, a review of recent literature is provided. To illustrate the existence of and motivations for feature removal, a case study of the browser platform Mozilla Firefox is presented. The results reveal feature removal to regularly occur on browser platforms for user- and developer-related features. Frequent reasons for feature removal involve unused features, security concerns, and bugs. Related motivations for feature removal are discussed from the platform owner's perspective. Implications for complementors and users are highlighted.
Modern web browsers are digital software platforms, as they allow third-parties to extend functionality by providing extensions. Given the intense competition, differentiation through provided functionality is a key factor for browser platforms. As browsers progress, they constantly release new features. Browsers might thereby enter complementary markets if they add functionality formerly provided by third-party extensions, which is referred to as ‘platform coring’. Previous studies missed the perspective of the involved parties. To address this gap, we conduct interviews with third-party and core developers in the security and privacy domain from Firefox and Chrome. In essence, the study provides three contributions. First, insights into stakeholder-specific issues concerning coring. Second, measures to prevent coring. Third, strategical guidance for developers and owners. Third-parties experienced and core developers acknowledged coring to occur on browser platforms. While developers with extrinsic motivations assess coring negatively, developers with intrinsic motivations perceive coring positively.
While Information Systems Research exists at the individual and workgroup levels, research on IS at the enterprise level is less common. The potential synergies between the study of enterprise systems (ES) and related fields have been underexplored and often treated as separate entities. The ongoing challenge is to seamlessly integrate technological advances and align business processes across organizations. While systems integration within an organization is common, changes occur when industry and ecosystem perspectives come into play. The four selected papers address different facets of the future role of enterprise ecosystems, including implementation challenges, ecosystem boundaries, and B2B platform specifics.
Missing out on life
(2020)
Mobile devices have become an integral part of everyday life due to
their portability. As literature shows, technology use is not only beneficial but also has dark sides, such as addiction. Parents face the need to balance perceived benefits and risks of children’s exposure to mobile technologies. However, no study has uncovered what kind of benefits and concerns parents consider when implementing technology-related rules. We built on qualitative responses of 300
parents of children aged two to thirteen to explore concerns about, and perceived benefits of children’s smartphone and tablet usage, as well as the rules parents have developed regarding technology use. Findings point to concerns regarding children’s development, as well as benefits for both children and parents, and ultimately to new insights about mobile technology mediation. These results provide practical guidance for parents, physicians and mobile industry
stakeholders, trying to ensure that children are acting responsibly with mobile technology.
The rise of open source models for software and hardware development has catalyzed the debate regarding sustainable business models. Open Source Software has already become a dominant part in the software industry, whereas Open Source Hardware is still a little-researched phenomenon but has the potential to do the same to manufacturing in a wide range of products. This article addresses this potential by introducing a research design to analyze the prototyping phase of six different Open Source Hardware projects tackling ecological, social, and economical challenges. Using a design science research methodology, a process model is developed to concretise the prototype development steps. The prototype phase is important because it is where fundamental decisions are made that affect the openness of the final product. This paper aims to advance the discourse on open production as a concept that enables companies to apply the aspect of openness towards collaboration-oriented and sustainable business models.
Looking for participation
(2022)
A stronger learner orientation through participatory learning increases learning motivation and results. But what does participatory learning mean? Where do learning factories and fabrication laboratories (FabLabs) stand in this context, and how can didactic implementation be improved in this respect? Using a newly developed analytical framework, which contains elements of the stage model of participation and general media didactics, we compare a FabLab and a learning factory example concerning the degree of participation. From this, we derive guidelines for designing participative teaching and learning processes in learning factories. We explain how FabLabs can be an inspiration for the didactic design of learning factories.
Halide perovskites
(2021)
Power relations within the area of blockchain governance are complex by definition and a comprehensive analysis that links technological and institutional elements is missing to date. The research that is presented with this article focuses on the visualization of the shifting power relations with the introduction of blockchain. For this purpose, the analysis leverages an adjusted version of the multi-stakeholder influence mapping tool. The analysis considers the various stakeholders within the multi-layered blockchain technology stack and compares three fundamental blockchain scenarios, including public and private blockchain settings. The findings show that public administrations face indeed less power with the introduction of blockchain, while new stakeholders come into play who wield influence rather uncontrolled. Nonetheless, public administrations are not powerless overall and remain influential stakeholders. This paper concludes that blockchain governance is not as democratic as blockchain enthusiasts tend to argue and derives corresponding opportunities for further research.
Enterprise Resource Planning (ERP) systems are critical to the success of enterprises, facilitating business operations through standardized digital processes. However, existing ERP systems are unsuitable for startups and small and medium-sized enterprises that grow quickly and require adaptable solutions with low barriers to entry. Drawing upon 15 explorative interviews with industry experts, we examine the challenges of current ERP systems using the task technology fit theory across companies of varying sizes. We describe high entry barriers, high costs of implementing implicit processes, and insufficient interoperability of already employed tools. We present a vision of a future business process platform based on three enablers: Business processes as first-class entities, semantic data and processes, and cloud-native elasticity and high availability. We discuss how these enablers address current ERP systems' challenges and how they may be used for research on the next generation of business software for tomorrow's enterprises.
Artificial intelligence (AI)-based technologies can increasingly perform knowledge work tasks, such as medical diagnosis. Thereby, it is expected that humans will not be replaced by AI but work closely with AI-based technology (“augmentation”). Augmentation has ethical implications for humans (e.g., impact on autonomy, opportunities to flourish through work), thus, developers and managers of AI-based technology have a responsibility to anticipate and mitigate risks to human workers. However, doing so can be difficult as AI encompasses a wide range of technologies, some of which enable fundamentally new forms of interaction. In this research-in-progress paper, we propose the development of a taxonomy to categorize unique characteristics of AI-based technology that influence the interaction and have ethical implications for human workers. The completed taxonomy will support researchers in forming cumulative knowledge on the ethical implications of augmentation and assist practitioners in the ethical design and management of AI-based technology in knowledge work.
Due to changing customer behavior in digitalization, banks urge to change their traditional value creation in order to improve interaction with customers. New digital technologies such as core banking solutions change organizational structures to provide organizational and individual affordances in IT-supported personal advisory. Based on adaptive structuration theory and with qualitative data from 24 German banks, we identify first, second and third order issues of organizational change in value creation, which are connected with a set of affordances and constraints as the outcomes for customer interaction.
The usage of data to improve or create business models has become vital for companies in the 21st century. However, to extract value from data it is important to understand the business model. Taxonomies for data-driven business models (DDBM) aim to provide guidance for the development and ideation of new business models relying on data. In IS research, however, different taxonomies have emerged in recent years, partly redundant, partly contradictory. Thus, there is a need to synthesize the common ground of these taxonomies within IS research. Based on 26 IS-related taxonomies and 30 cases, we derive and define 14 generic building blocks of DDBM to develop a consolidated taxonomy that represents the current state-of-the-art. Thus, we integrate existing research on DDBM and provide avenues for further exploration of data-induced potentials for business models as well as for the development and analysis of general or industry-specific DDBM.
A key problem in automatic annotation of historical corpora is inconsistent spelling. Because the spelling of some word forms can differ between texts, a language model trained on already annotated treebanks may fail to recognize known word forms due to differences in spelling. In the present work, we explore the feasibility of an unsupervised method for spelling-adjustment for the purpose of improved part of speech (POS) tagging. To this end, we present a method for spelling normalization based on weighted edit distances, which exploits within-text spelling variation. We then evaluate the improvement in taging accuracy resulting from between-texts spelling normalization in two tagging experiments on several Early New High German (ENHG) texts.
Physiological and genomic variation among cryptic species of a marsh snail (Melampus bidentatus)
(2021)
During the outbreak of the COVID-19 pandemic, many people shared their symptoms across Online Social Networks (OSNs) like Twitter, hoping for others’ advice or moral support. Prior studies have shown that those who disclose health-related information across OSNs often tend to regret it and delete their publications afterwards. Hence, deleted posts containing sensitive data can be seen as manifestations of online regrets. In this work, we present an analysis of deleted content on Twitter during the outbreak of the COVID-19 pandemic. For this, we collected more than 3.67 million tweets describing COVID-19 symptoms (e.g., fever, cough, and fatigue) posted between January and April 2020. We observed that around 24% of the tweets containing personal pronouns were deleted either by their authors or by the platform after one year.
As a practical application of the resulting dataset, we explored its suitability for the automatic classification of regrettable content on Twitter.
Spectral detection enables multi-color fluorescence fluctuation spectroscopy studies in living cells
(2021)
Background:
Anti-TNFα monoclonal antibodies (mAbs) are a well-established treatment for patients with Crohn’s disease (CD). However, subtherapeutic concentrations of mAbs have been related to a loss of response during the first year of therapy1. Therefore, an appropriate dosing strategy is crucial to prevent the underexposure of mAbs for those patients. The aim of our study was to assess the impact of different dosing strategies (fixed dose or body size descriptor adapted) on drug exposure and the target concentration attainment for two different anti-TNFα mAbs: infliximab (IFX, body weight (BW)-based dosing) and certolizumab pegol (CZP, fixed dosing). For this purpose, a comprehensive pharmacokinetic (PK) simulation study was performed.
Methods:
A virtual population of 1000 clinically representative CD patients was generated based on the distribution of CD patient characteristics from an in-house clinical database (n = 116). Seven dosing regimens were investigated: fixed dose and per BW, lean BW (LBW), body surface area, height, body mass index and fat-free mass. The individual body size-adjusted doses were calculated from patient generated body size descriptor values. Then, using published PK models for IFX and CZP in CD patients2,3, for each patient, 1000 concentration–time profiles were simulated to consider the typical profile of a specific patient as well as the range of possible individual profiles due to unexplained PK variability across patients. For each dosing strategy, the variability in maximum and minimum mAb concentrations (Cmax and Cmin, respectively), area under the concentration-time curve (AUC) and the per cent of patients reaching target concentration were assessed during maintenance therapy.
Results:
For IFX and CZP, Cmin showed the highest variability between patients (CV ≈110% and CV ≈80%, respectively) with a similar extent across all dosing strategies. For IFX, the per cent of patients reaching the target (Cmin = 5 µg/ml) was similar across all dosing strategies (~15%). For CZP, the per cent of patients reaching the target average concentration of 17 µg/ml ranged substantially (52–71%), being the highest for LBW-adjusted dosing.
Conclusion:
By using a PK simulation approach, different dosing regimen of IFX and CZP revealed the highest variability for Cmin, the most commonly used PK parameter guiding treatment decisions, independent upon dosing regimen. Our results demonstrate similar target attainment with fixed dosing of IFX compared with currently recommended BW-based dosing. For CZP, the current fixed dosing strategy leads to comparable percentage of patients reaching target as the best performing body size-adjusted dosing (66% vs. 71%, respectively).
Public blockchain
(2020)
Blockchain has the potential to change business transactions to a major extent. Thereby, underlying consensus algorithms are the core mechanism to achieve consistency in distributed infrastructures. Their application aims for transparency and accountability in societal transactions. As a result of missing reviews holistically covering consensus algorithms, we aim to (1) identify prevalent consensus algorithms for public blockchains, and (2) address the resource perspective with a sustainability consideration (whereby we address the three spheres of sustainability). Our systematic literature review identified 33 different consensus algorithms for public blockchains. Our contribution is twofold: first, we provide a systematic summary of consensus algorithms for public blockchains derived from the scientific literature as well as real-world applications and systemize them according to their research focus; second, we assess the sustainability of consensus algorithms using a representative sample and thereby highlight the gaps in literature to address the holistic sustainability of consensus algorithms.
Web Tracking
(2018)
Web tracking seems to become ubiquitous in online business and leads to increased privacy concerns of users. This paper provides an overview over the current state of the art of web-tracking research, aiming to reveal the relevance and methodologies of this research area and creates a foundation for future work. In particular, this study addresses the following research questions: What methods are followed? What results have been achieved so far? What are potential future research areas? For these goals, a structured literature review based upon an established methodological framework is conducted. The identified articles are investigated with respect to the applied research methodologies and the aspects of web tracking they emphasize.
E-Mail tracking uses personalized links and pictures for gathering information on user behavior, for example, where, when, on what kind of device, and how often an e-mail has been read. This information can be very useful for marketing purposes. On the other hand, privacy and security requirements of customers could be violated by tracking. This paper examines how e-mail tracking works, how it can be detected automatically, and to what extent it is used in German e-commerce. We develop a detection model and software tool in order to collect and analyze more than 600 newsletter e-mails from companies of several different industries. The results show that the usage of e-mail tracking in Germany is prevalent but also varies depending on the industry.
Plant invasions, resilience, economics, and restoration - can fynbos pay for alien management?
(2012)
This study aims to bring together scattered research findings on user satisfaction with mobile government apps into a unified framework. The researchers analyzed 70 high-quality papers from leading journals and conferences and systematically integrated different frameworks and case studies to reflect the importance of the field over time while also highlighting methodological and geographical research gaps. The study achieved a significant methodological advance by developing codebooks for empirical analysis utilizing the App Store. This approach validated the framework’s dimensions on 8,524 reviews, demonstrating the framework’s applicability to platform-based apps and identifying critical areas for future research. Combining academic insights with practical findings, this research provides comprehensive guidance for developing and evaluating user-centered mobile government apps, facilitating improved service delivery and alignment with user expectations.
In times of digitalization, the collection and modeling of business processes is still a challenge for companies. The demand for trustworthy process models that reflect the actual execution steps therefore increases. The respective kinds of processes significantly determine both, business process analysis and the conception of future target processes and they are the starting point for any kind of change initiatives. Existing approaches to model as-is processes, like process mining, are exclusively focused on reconstruction. Therefore, transactional protocols and limited data from a single application system are used. Heterogeneous application landscapes and business processes that are executed across multiple application systems, on the contrary, are one of the main challenges in process mining research. Using RFID technology is hence one approach to close the existing gap between different application systems. This paper focuses on methods for data collection from real world objects via RFID technology and possible combinations with application data (process mining) in order to realize a cross system mining approach.
The increasing prevalence and ubiquity of digital technologies is changing the needs and expectations of patients towards healthcare services. As a result, a plethora of patient-centered services edges into the healthcare market. Since digital technologies bear the potential to surmount barriers in time and space, patients increasingly demand real-time or near-time healthcare services. Amongst a cloud of related concepts in the context of digital health, one term increasingly typifies this impulse: on-demand healthcare. While this term can be noticeably found in practice, there is hardly some theoretical foundation so far. Against this background, the aim of this paper is to address this research gap and to explore the phenomenon of on-demand healthcare. Based on a design-science approach including a literature review and analysis of in-depth interviews and empirical cases, the outcome of this paper is twofold: (1) a conceptual framework and (2) a proposal for a definition of on-demand healthcare.
The variability of bone strength and skeletal robustness of young men - how it can be influenced
(2011)
Virtual reality can have advantages for education and learning. However, it must be adequately designed so that the learner benefits from the technological possibilities. Understanding the underlying effects of the virtual learning environment and the learner’s prior experience with virtual reality or prior knowledge of the content is necessary to design a proper virtual learning environment. This article presents a pre-study testing the design of a virtual learning environment for engineering vocational training courses. In the pre-study, 12 employees of two companies joined the training course in one of the two degrees of immersion (desktop VR and VR HMD). Quantitative results on learning success, cognitive load, usability, and motivation and qualitative learning process data were presented. The qualitative data assessment shows that overall, the employees were satisfied with the learning environment regardless of the level of immersion and that the participants asked for more guidance and structure accompanying the learning process. Further research is needed to test for solid group differences.
Learning in virtual, immersive environments must be well-designed to foster learning instead of overwhelming and distracting the learner. So far, learning instructions based on cognitive load theory recommend keeping the learning instructions clean and simple to reduce the extraneous cognitive load of the learner to foster learning performance. The advantages of immersive learning, such as multiple options for realistic simulation, movement and feedback, raise questions about the tension between an increase of excitement and flow with highly realistic environments on the one hand and a reduction of cognitive load by developing clean and simple surroundings on the other hand. This study aims to gain insights into learners' cognitive responses during the learning process by continuously assessing cognitive load through eye-tracking. The experiment compares two distinct immersive learning environments and varying methods of content presentation.