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Wealth and income distributions are known to feature country-specific Pareto exponents for their long power-law tails. To propose a rationale for this, we introduce an agent-based dynamic model and use Monte Carlo simulations to unveil the wealth distributions in closed and open economical systems. The standard money-exchange scenario is supplemented with the position-exchange agent dynamics that vitally affects the Pareto law. Specifically, in closed systems with position-exchange dynamics the power law changes to an exponential shape, while for open systems with traps the Pareto law remains valid.
Optical flow models as an open benchmark for radar-based precipitation nowcasting (rainymotion v0.1)
(2019)
Quantitative precipitation nowcasting (QPN) has become an essential technique in various application contexts, such as early warning or urban sewage control. A common heuristic prediction approach is to track the motion of precipitation features from a sequence of weather radar images and then to displace the precipitation field to the imminent future (minutes to hours) based on that motion, assuming that the intensity of the features remains constant (“Lagrangian persistence”). In that context, “optical flow” has become one of the most popular tracking techniques. Yet the present landscape of computational QPN models still struggles with producing open software implementations. Focusing on this gap, we have developed and extensively benchmarked a stack of models based on different optical flow algorithms for the tracking step and a set of parsimonious extrapolation procedures based on image warping and advection. We demonstrate that these models provide skillful predictions comparable with or even superior to state-of-the-art operational software. Our software library (“rainymotion”) for precipitation nowcasting is written in the Python programming language and openly available at GitHub (https://github.com/hydrogo/rainymotion, Ayzel et al., 2019). That way, the library may serve as a tool for providing fast, free, and transparent solutions that could serve as a benchmark for further model development and hypothesis testing – a benchmark that is far more advanced than the conventional benchmark of Eulerian persistence commonly used in QPN verification experiments.
During the last few decades, the rapid separation of the Small Aral Sea from the isolated basin has changed its hydrological and ecological conditions tremendously. In the present study, we developed and validated the hybrid model for the Syr Darya River basin based on a combination of state-of-the-art hydrological and machine learning models. Climate change impact on freshwater inflow into the Small Aral Sea for the projection period 2007-2099 has been quantified based on the developed hybrid model and bias corrected and downscaled meteorological projections simulated by four General Circulation Models (GCM) for each of three Representative Concentration Pathway scenarios (RCP). The developed hybrid model reliably simulates freshwater inflow for the historical period with a Nash-Sutcliffe efficiency of 0.72 and a Kling-Gupta efficiency of 0.77. Results of the climate change impact assessment showed that the freshwater inflow projections produced by different GCMs are misleading by providing contradictory results for the projection period. However, we identified that the relative runoff changes are expected to be more pronounced in the case of more aggressive RCP scenarios. The simulated projections of freshwater inflow provide a basis for further assessment of climate change impacts on hydrological and ecological conditions of the Small Aral Sea in the 21st Century.
OpenForecast
(2019)
The development and deployment of new operational runoff forecasting systems are a strong focus of the scientific community due to the crucial importance of reliable and timely runoff predictions for early warnings of floods and flashfloods for local businesses and communities. OpenForecast, the first operational runoff forecasting system in Russia, open for public use, is presented in this study. We developed OpenForecast based only on open-source software and data-GR4J hydrological model, ERA-Interim meteorological reanalysis, and ICON deterministic short-range meteorological forecasts. Daily forecasts were generated for two basins in the European part of Russia. Simulation results showed a limited efficiency in reproducing the spring flood of 2019. Although the simulations managed to capture the timing of flood peaks, they failed in estimating flood volume. However, further implementation of the parsimonious data assimilation technique significantly alleviates simulation errors. The revealed limitations of the proposed operational runoff forecasting system provided a foundation to outline its further development and improvement.
We construct eta- and rho-invariants for Dirac operators, on the universal covering of a closed manifold, that are invariant under the projective action associated to a 2-cocycle of the fundamental group. We prove an Atiyah-Patodi-Singer index theorem in this setting, as well as its higher generalisation. Applications concern the classification of positive scalar curvature metrics on closed spin manifolds. We also investigate the properties of these twisted invariants for the signature operator and the relation to the higher invariants.
We analyse the top tail of the wealth distribution in France, Germany, and Spain using the first and second waves of the Household Finance and Consumption Survey (HFCS). Since top wealth is likely to be under-represented in household surveys, we integrate big fortunes from rich lists, estimate a Pareto distribution, and impute the missing rich. In addition to the Forbes list, we rely on national rich lists since they represent a broader base of the big fortunes in those countries. As a result, the top 1% wealth share increases notably for the three selected countries after imputing the top wealth. We find that national rich lists can improve the estimation of the Pareto coefficient in particular when the list of national USD billionaires is short.
Double Jeopardy
(2019)
The present study investigates whether secondary traumatization (i.e., family history of Holocaust survival and secondary exposure to captivity) is implicated in subjective age. Women exposed to different levels of secondary traumatization (N = 177) were assessed. Analyses of variance (ANOVAs) revealed that a Holocaust background and husband's captivity had a marginally significant positive effect on age appearance. Women with a Holocaust background whose husbands were held captive reported older interest age, indicating double jeopardy for older subjective age when two sources of secondary traumatization are present. A similar trend existed for behavior age. Possible explanations for these complex findings of risk and resilience are discussed.
While the underlying mechanisms of Parkinson’s disease (PD) are still insufficiently studied, a complex interaction between genetic and environmental factors is emphasized. Nevertheless, the role of the essential trace element zinc (Zn) in this regard remains controversial. In this study we altered Zn balance within PD models of the versatile model organism Caenorhabditis elegans (C. elegans) in order to examine whether a genetic predisposition in selected genes with relevance for PD affects Zn homeostasis. Protein-bound and labile Zn species act in various areas, such as enzymatic catalysis, protein stabilization pathways and cell signaling. Therefore, total Zn and labile Zn were quantitatively determined in living nematodes as individual biomarkers of Zn uptake and bioavailability with inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) or a multi-well method using the fluorescent probe ZinPyr-1. Young and middle-aged deletion mutants of catp-6 and pdr-1, which are orthologues of mammalian ATP13A2 (PARK9) and parkin (PARK2), showed altered Zn homeostasis following Zn exposure compared to wildtype worms. Furthermore, age-specific differences in Zn uptake were observed in wildtype worms for total as well as labile Zn species. These data emphasize the importance of differentiation between Zn species as meaningful biomarkers of Zn uptake as well as the need for further studies investigating the role of dysregulated Zn homeostasis in the etiology of PD.
Hot-electron-induced reactions are more and more recognized as a critical and ubiquitous reaction in heterogeneous catalysis. However, the kinetics of these reactions is still poorly understood, which is also due to the complexity of plasmonic nanostructures. We determined the reaction rates of the hot-electron-mediated reaction of 4-nitrothiophenol (NTP) on gold nanoparticles (AuNPs) using fractal kinetics as a function of the laser wavelength and compared them with the plasmonic enhancement of the system. The reaction rates can be only partially explained by the plasmonic response of the NPs. Hence, synchrotron X-ray photoelectron spectroscopy (XPS) measurements of isolated NTP-capped AuNP clusters have been performed for the first time. In this way, it was possible to determine the work function and the accessible valence band states of the NP systems. The results show that besides the plasmonic enhancement, the reaction rates are strongly influenced by the local density of the available electronic states of the system.
Sensors composed of a porous silicon monolayer covered with a film of nanostructured gold layer, which provide two optical signal transduction methods, are fabricated and thoroughly characterized concerning their sensing performance. For this purpose, silicon substrates were electrochemically etched in order to obtain porous silicon monolayers, which were subsequently immersed in gold salt solution facilitating the formation of a porous gold nanoparticle layer on top of the porous silicon. The deposition process was monitored by reflectance spectroscopy, and the appearance of a dip in the interference pattern of the porous silicon layer was observed. This dip can be assigned to the absorption of light by the deposited gold nanostructures leading to localized surface plasmon resonance. The bulk sensitivity of these sensors was determined by recording reflectance spectra in media having different refractive indices and compared to sensors exclusively based on porous silicon or gold nanostructures. A thorough analysis of resulting shifts of the different optical signals in the reflectance spectra on the wavelength scale indicated that the optical response of the porous silicon sensor is not influenced by the presence of a gold nanostructure on top. Moreover, the adsorption of thiol-terminated polystyrene to the sensor surface was solely detected by changes in the position of the dip in the reflectance spectrum, which is assigned to localized surface plasmon resonance in the gold nanostructures. The interference pattern resulting from the porous silicon layer is not shifted to longer wavelengths by the adsorption indicating the independence of the optical response of the two nanostructures, namely porous silicon and nanostructured gold layer, to refractive index changes and pointing to the successful realization of two sensors in one spot.
This study investigates the effect of different anticonsumption constructs on consumer wellbeing. The study assumes that people will only lower their level of consumption if doing so does not also lower personal wellbeing. More precisely, this research investigates how specific subtypes of sustainable anticonsumption (e.g., voluntary simplicity, collaborative consumption, and debt-free living) relate to different states of consumer's wellbeing (e.g., financial, psychosocial, and subjective wellbeing). This work also examines whether consumer empowerment can improve personal wellbeing and strengthen the anticonsumption wellbeing relationship. The results show that voluntarily foregoing consumption does not reduce wellbeing and consumer empowerment plays a significant role in supporting sustainable pathways to consumer wellbeing. This study reasons that empowerment improves consumer sovereignty, but may be detrimental for consumers heavily concerned about debt-free living. The present investigation concludes by proposing implications for public and consumer policymakers wishing to promote appropriate sustainable (anticonsumption) pathways to consumer wellbeing.
Quadruple-shape hydrogels
(2019)
The capability of directed movements by two subsequent shape changes could be implemented in shape-memory hydrogels by incorporation of two types of crystallizable side chains While in non-swollen polymer networks even more directed movements could be realized, the creation of multi-shape hydrogels is still a challenge. We hypothesize that a quadruple-shape effect in hydrogels can be realized, when a swelling capacity almost independent of temperature is generated, whereby directed movements could be enabled, which are not related to swelling. In this case, entropy elastic recovery could be realized by hydrophilic segments and the fixation of different macroscopic shapes by means of three semi-crystalline side chains generating temporary crosslinks. Monomethacrylated semi-crystalline oligomers were connected as side chains in a hydrophilic polymer network via radical copolymerization. Computer assisted modelling was utilized to design a demonstrator capable of complex shape shifts by creating a casting mold via 3D printing from polyvinyl alcohol. The demonstrator was obtained after copolymerization of polymer network forming components within the mold, which was subsequently dissolved in water. A thermally-induced quadruple-shape effect was realized after equilibrium swelling of the polymer network in water. Three directed movements were successfully obtained when the temperature was continuously increased from 5 degrees C to 90 degrees C with a recovery ratio of the original shape above 90%. Hence, a thermally-induced quadruple-shape effect as new record for hydrogels was realized. Here, the temperature range for the multi-shape effect was limited by water as swelling media (0 degrees C-100 degrees C), simultaneously distinctly separated thermal transitions were required, and the overall elasticity indispensable for successive deformations was reduced as result of partially chain segment orientation induced by swelling in water. Conclusively the challenges for penta- or hexa-shape gels are the design of systems enabling higher elastic deformability and covering a larger temperature range by switching to a different solvent.
Shape-memory polymer actuators often contain crystallizable polyester segments. Here, the influence of accelerated hydrolytic degradation on the actuation performance in copolymer networks based on oligo(epsilon-caprolactone) dimethacrylate (OCL) and n-butyl acrylate is studied The semi-crystalline OCL was utilized as crosslinker with molecular weights of 2.3 and 15.2 kg.mol(-1) (ratio: 1:1 wt%) and n-butyl acrylate (25 wt% relative to OCL content) acted as softening agent creating the polymer main chain segments within the network architecture. The copolymer networks were programmed by 50% elongation and were degraded by means of alkaline hydrolysis utilizing sodium hydroxide solution (pH = 13). Experiments were performed in the range of the broad melting range of the actuators at 40 degrees C. The degradation of test specimen was monitored by the sample mass, which was reduced by 25 wt% within 105 d .45 degradation products, fragments of OCL with molecular masses ranging from 400 to 50.000 g.mol(-1) could be detected by NMR spectroscopy and GPC measurements. The cleavage of ester groups included in OCL segments resulted in a decrease of the melting temperature (T-m) related to the actuator domains (amorphous at the temperature of degradation) and simultaneously, the T-m associated to the skeleton domain was increased (semi-crystalline at the temperature of degradation). The alkaline hydrolysis decreased the polymer chain orientation of OCL domains until a random alignment of crystalline domains was obtained. This result was confirmed by cyclic thermomechanical actuation tests. The performance of directed movements decreased almost linearly as function of degradation time resulting in the loss of functionality when the orientation of polymer chains disappeared. Here, actuators were able to provide reversible movements until 91 d when the accelerated bulk degradation procedure using alkaline hydrolysis (pH = 13) was applied. Accordingly, a lifetime of more than one year can be guaranteed under physiological conditions (pH = 7.4) when, e.g., artificial muscles for biomimetic robots as potential application for these kind of shape-memory polymer actuators will be addressed.
The removal, redistribution, and transient storage of sediments in tectonically active mountain belts is thought to exert a first-order control on shallow crustal stresses, fault activity, and hence on the spatiotemporal pattern of regional deformation processes. Accordingly, sediment loading and unloading cycles in intermontane sedimentary basins may inhibit or promote intrabasinal faulting, respectively, but unambiguous evidence for this potential link has been elusive so far. Here we combine 2D numerical experiments that simulate contractional deformation in a broken-foreland setting (i.e., a foreland where shortening is diachronously absorbed by spatially disparate, reverse faults uplifting basement blocks) with field data from intermontane basins in the NW Argentine Andes. Our modeling results suggest that thicker sedimentary fills (>0.7-1.0 km) may suppress basinal faulting processes, while thinner fills (<0.7 km) tend to delay faulting. Conversely, the removal of sedimentary loads via fluvial incision and basin excavation promotes renewed intrabasinal faulting. These results help to better understand the tectono-sedimentary history of intermontane basins that straddle the eastern border of the Andean Plateau in northwestern Argentina. For example, the Santa Maria and the Humahuaca basins record intrabasinal deformation during or after sediment unloading, while the Quebrada del Toro Basin reflects the suppression of intrabasinal faulting due to loading by coarse conglomerates. We conclude that sedimentary loading and unloading cycles may exert a fundamental control on spatiotemporal deformation patterns in intermontane basins of tectonically active broken forelands. (C) 2018 Elsevier B.V. All rights reserved.
On a smooth complete Riemannian spin manifold with smooth compact boundary, we demonstrate that Atiyah-Singer Dirac operator in depends Riesz continuously on perturbations of local boundary conditions The Lipschitz bound for the map depends on Lipschitz smoothness and ellipticity of and bounds on Ricci curvature and its first derivatives as well as a lower bound on injectivity radius away from a compact neighbourhood of the boundary. More generally, we prove perturbation estimates for functional calculi of elliptic operators on manifolds with local boundary conditions.
Recent years have seen a considerable broadening of the ambitions in urban sustainability policy-making. With its Sustainable Development Goal (SDG) 11 Making cities and human settlements inclusive, safe, resilient and sustainable, the 2030 Agenda stresses the critical role of cities in achieving sustainable development. In the context of SDG17 on partnerships, emphasis is also placed on the role of researchers and other scientific actors as change agents in the sustainability transformation. Against this backdrop, this article sheds light on different pathways through which science can contribute to urban sustainability. In particular, we discern four forms of science-policy-society interactions as key vectors: 1. sharing knowledge and providing scientific input to urban sustainability policy-making; 2. implementing transformative research projects; 3. contributing to local capacity building; and 4. self-governing towards sustainability. The pathways of influence are illustrated with empirical examples, and their interlinkages and limitations are discussed. We contend that there are numerous opportunities for actors from the field of sustainability science to engage with political and societal actors to enhance sustainable development at the local level.
We present an analysis of two pulsating subdwarf B stars PHL 457 and EQ Psc observed during the K2 mission. The K2 light curves of both stars show variation consistent with irradiation of a cooler companion by the hot subdwarf. They also show higher frequency oscillations consistent with pulsation. Using new spectroscopic data, we measured the radial velocity, effective temperature, surface gravity, and helium abundance of both hot subdwarfs as a function of orbital phase. We confirm the previously published spectroscopic orbit of PHL 457, and present the first spectroscopic orbit of EQ Psc. The orbital periods are 0.313 and 0.801 d, respectively. For EQPsc, we find a strong correlation between T-eff and orbital phase, due to contribution of light from the irradiated companion. We calculated amplitude spectra, identified significant pulsation frequencies, and searched for multiplets and asymptotic period spacings. By means of multiplets and period spacing, we identified the degrees of several pulsation modes in each star. The g-mode multiplets indicate subsynchronous core rotation with periods of 4.6 d (PHL 457) and 9.4 d (EQ Psc). We made spectral energy disctribution (SED) fits of PHL 457 and EQ Psc using available broad-band photometry and Gaia data. While the SED of PHL 457 shows no evidence of a cool companion, the SED for EQPsc clearly shows an infrared (IR) access consistent with a secondary with a temperature of about 6800K and a radius of 0.23 R-circle dot. This is the first detection of an IR access in any sdB + dM binary.
Above and underground hydrological processes depend on soil moisture (SM) variability, driven by different environmental factors that seldom are well-monitored, leading to a misunderstanding of soil water temporal patterns. This study investigated the stability of the SM temporal dynamics to different monitoring temporal resolutions around the border between two soil types in a tropical watershed. Four locations were instrumented in a small-scale watershed (5.84 km(2)) within the tropical coast of Northeast Brazil, encompassing different soil types (Espodossolo Humiluvico or Carbic Podzol, and Argissolo Vermelho-Amarelo or Haplic Acrisol), land covers (Atlantic Forest, bush vegetation, and grassland) and topographies (flat and moderate slope). The SM was monitored at a temporal resolution of one hour along the 2013-2014 hydrological year and then resampled a resolutions of 6 h, 12 h, 1 day, 2 days, 4 days, 7 days, and 15 days. Descriptive statistics, temporal variability, time-stability ranking, and hierarchical clustering revealed uneven associations among SM time components. The results show that the time-invariant component ruled SM temporal variability over the time-varying parcel, either at high or low temporal resolutions. Time-steps longer than 2 days affected the mean statistical metrics of the SM time-variant parcel. Additionally, SM at downstream and upstream sites behaved differently, suggesting that the temporal mean was regulated by steady soil properties (slope, restrictive layer, and soil texture), whereas their temporal anomalies were driven by climate (rainfall) and hydrogeological (groundwater level) factors. Therefore, it is concluded that around the border between tropical soil types, the distinct behaviour of time-variant and time-invariant components of SM time series reflects different combinations of their soil properties.
The frequent production of the hepatotoxin microcystin (MC) and its impact on the lifestyle of bloom-forming cyanobacteria are poorly understood. Here, we report that MC interferes with the assembly and the subcellular localization of RubisCO, in Microcystis aeruginosa PCC7806. Immunofluorescence, electron microscopic and cellular fractionation studies revealed a pronounced heterogeneity in the subcellular localization of RubisCO. At high cell density, RubisCO particles are largely separate from carboxysomes in M. aeruginosa and relocate to the cytoplasmic membrane under high-light conditions. We hypothesize that the binding of MC to RubisCO promotes its membrane association and enables an extreme versatility of the enzyme. Steady-state levels of the RubisCO CO2 fixation product 3-phosphoglycerate are significantly higher in the MC-producing wild type. We also detected noticeable amounts of the RubisCO oxygenase reaction product secreted into the medium that may support the mutual interaction of M. aeruginosa with its heterotrophic microbial community.
The Value of Empirical Data for Estimating the Parameters of a Sociohydrological Flood Risk Model
(2019)
In this paper, empirical data are used to estimate the parameters of a sociohydrological flood risk model. The proposed model, which describes the interactions between floods, settlement density, awareness, preparedness, and flood loss, is based on the literature. Data for the case study of Dresden, Germany, over a period of 200years, are used to estimate the model parameters through Bayesian inference. The credibility bounds of their estimates are small, even though the data are rather uncertain. A sensitivity analysis is performed to examine the value of the different data sources in estimating the model parameters. In general, the estimated parameters are less biased when using data at the end of the modeled period. Data about flood awareness are the most important to correctly estimate the parameters of this model and to correctly model the system dynamics. Using more data for other variables cannot compensate for the absence of awareness data. More generally, the absence of data mostly affects the estimation of the parameters that are directly related to the variable for which data are missing. This paper demonstrates that combining sociohydrological modeling and empirical data gives additional insights into the sociohydrological system, such as quantifying the forgetfulness of the society, which would otherwise not be easily achieved by sociohydrological models without data or by standard statistical analysis of empirical data.
In Germany, the irrigation sector accounts for only 1% of water use. In recent years, however, this sector has attracted more attention due to the occurrence of severe drought periods. Irrigation scheduling systems could support adaptation strategies but little is known about current providers, performance and users. In this study we aimed to depict the current situation of the existence and functioning of irrigation scheduling systems available in Germany. Six methods were identified and assessed based on direct interviews with end-users and a comparative analysis. The results showed a positive feedback from the users. However, the recommendations were rarely implemented, while only the seasonal irrigation requirement was considered to support actual water abstraction. These results were corroborated by the comparative analysis. Five of the six irrigation scheduling systems estimated the seasonal irrigation amount consistently, while wider differences were found by looking at the irrigation season and at the number of irrigations. Overall, it is found that irrigation support systems are valuable tools for supporting adaptation strategies to fast changes in agro-environmental conditions. However, specific assessments based on real measurements should be considered in order to improve the performance of the systems and provide more consistent support to end-users. (c) 2019 John Wiley & Sons, Ltd.
The improvement of process representations in hydrological models is often only driven by the modelers' knowledge and data availability. We present a comprehensive comparison between two hydrological models of different complexity that is developed to support (1) the understanding of the differences between model structures and (2) the identification of the observations needed for model assessment and improvement. The comparison is conducted on both space and time and by aggregating the outputs at different spatiotemporal scales. In the present study, mHM, a process‐based hydrological model, and ParFlow‐CLM, an integrated subsurface‐surface hydrological model, are used. The models are applied in a mesoscale catchment in Germany. Both models agree in the simulated river discharge at the outlet and the surface soil moisture dynamics, lending their supports for some model applications (drought monitoring). Different model sensitivities are, however, found when comparing evapotranspiration and soil moisture at different soil depths. The analysis supports the need of observations within the catchment for model assessment, but it indicates that different strategies should be considered for the different variables. Evapotranspiration measurements are needed at daily resolution across several locations, while highly resolved spatially distributed observations with lower temporal frequency are required for soil moisture. Finally, the results show the impact of the shallow groundwater system simulated by ParFlow‐CLM and the need to account for the related soil moisture redistribution. Our comparison strategy can be applied to other models types and environmental conditions to strengthen the dialog between modelers and experimentalists for improving process representations in Earth system models.
In this paper, we examine the influence of the 27 October 2012, M-w 7.8 earthquake on landslide occurrence in the southern half of Haida Gwaii (formerly Queen Charlotte Islands), British Columbia, Canada. Our 1350 km(2) study area is undisturbed, primarily forested terrain that has not experienced road building or timber harvesting. Our inventory of landslide polygons is based on optical airborne and spaceborne images acquired between 2007 and 2018, from which we extracted and mapped 446 individual landslides (an average of 33 landslides per 100 km(2)). The landslide rate in years without major earthquakes averages 19.4 per year, or 1.4/100 km(2)/year, and the annual average area covered by non-seismically triggered landslides is 35 ha/year. The number of landslides identified in imagery closely following the 2012 earthquake, and probably triggered by it, is 244 or an average of about 18 landslides per 100 km(2). These landslides cover a total area of 461 ha. In the following years-2013-2016 and 2016-2018-the number of landslides fell, respectively, to 26 and 13.5 landslides per year. In non-earthquake years, most landslides happen on south-facing slopes, facing the prevailing winds. In contrast, during or immediately after the earthquake, up to 32% of the landslides occurred on north and northwest-facing slopes. Although we could not find imagery from the day after the earthquake, overview reconnaissance flights 10 and 16 days later showed that most of the landslides were recent, suggesting they were co-seismic.
Children born preterm are at higher risk to develop language deficits. Auditory speech discrimination deficits may be early signs for language developmental problems. The present study used functional near-infrared spectroscopy to investigate neural speech discrimination in 15 preterm infants at term-equivalent age compared to 15 full term neonates. The full term group revealed a significantly greater hemodynamic response to forward compared to backward speech within the left hemisphere extending from superior temporal to inferior parietal and middle and inferior frontal areas. In contrast, the preterm group did not show differences in their hemodynamic responses during forward versus backward speech, thus, they did not discriminate speech from nonspeech. Groups differed significantly in their responses to forward speech, whereas they did not differ in their responses to backward speech. The significant differences between groups point to an altered development of the functional network underlying language acquisition in preterm infants as early as in term-equivalent age.
Verbraucherbildung ist bundesweit vielfältig in curricularen Vorgaben verankert. Fachfremde Lehrpersonen benötigen Professionalisierungsangebote, um die Verbraucherbildung
als Querschnittsaufgabe in ihren Fächern implementieren zu können. Erkenntnisse aus der Professionalisierungsforschung werden daher im Beitrag in Bezug auf das cLEVER-Projekt
zusammengetragen, um sie für Fortbildungsangebote nutzbar zu machen.
Industrial production and use of boron compounds have increased during the last decades, especially for the manufacture of borosilicate glass, fiberglass, metal alloys and flame retardants. This study was conducted in two districts of Balikesir; Bandirma and Bigadic, which geographically belong to the Marmara Region of Turkey. Bandirma is the production and exportation zone for the produced boric acid and some borates and Bigadic has the largest B deposits in Turkey. 102 male workers who were occupationally exposed to boron from Bandirma and 110 workers who were occupationally and environmentally exposed to boron from Bigadic participated to our study. In this study the DNA damage in the sperm, blood and buccal cells of 212 males was evaluated by comet and micronucleus assays. No significant increase in the DNA damage in blood, sperm and buccal cells was observed in the residents exposed to boron both occupationally and environmentally (p = 0.861) for Comet test in the sperm samples, p = 0.116 for Comet test in the lymphocyte samples, p = 0.042 for micronucleus (MN) test, p = 0.955 for binucleated cells (BN), p = 1.486 for condensed chromatin (CC), p = 0.455 for karyorrhectic cells (KHC), p = 0.541 for karyolitic cells (KLY), p = 1.057 for pyknotic cells (PHC), p = 0.331 for nuclear bud (NBUD)). No correlations were seen between blood boron levels and tail intensity values of the sperm samples, lymphocyte samples, frequencies of MN, BN, KHC, KYL, PHC and NBUD. The results of this study came to the same conclusions of the previous studies that boron does not induce DNA damage even under extreme exposure conditions.
The endosperm is an ephemeral tissue that nourishes the developing embryo, similar to the placenta in mammals. In most angiosperms, endosperm development starts as a syncytium, in which nuclear divisions are not followed by cytokinesis. The timing of endosperm cellularization largely varies between species, and the event triggering this transition remains unknown. Here we show that increased auxin biosynthesis in the endosperm prevents its cellularization, leading to seed arrest. Auxin-overproducing seeds phenocopy paternal-excess triploid seeds derived from hybridizations of diploid maternal plants with tetraploid fathers. Concurrently, auxin-related genes are strongly overexpressed in triploid seeds, correlating with increased auxin activity. Reducing auxin biosynthesis and signaling reestablishes endosperm cellularization in triploid seeds and restores their viability, highlighting a causal role of increased auxin in preventing endosperm cellularization. We propose that auxin determines the time of endosperm cellularization, and thereby uncovered a central role of auxin in establishing hybridization barriers in plants.
MADS-box transcription factors (TFs) are ubiquitous in eukaryotic organisms and play major roles during plant development. Nevertheless, their function in seed development remains largely unknown. Here, we show that the imprinted Arabidopsis thaliana MADS-box TF PHERES1 (PHE1) is a master regulator of paternally expressed imprinted genes, as well as of non-imprinted key regulators of endosperm development. PHE1 binding sites show distinct epigenetic modifications on maternal and paternal alleles, correlating with parental-specific transcriptional activity. Importantly, we show that the CArG-box-like DNA-binding motifs that are bound by PHE1 have been distributed by RC/Helitron transposable elements. Our data provide an example of the molecular domestication of these elements which, by distributing PHE1 binding sites throughout the genome, have facilitated the recruitment of crucial endosperm regulators into a single transcriptional network.
The nuclear envelope consists of the outer and the inner nuclear membrane, the nuclear lamina and the nuclear pore complexes, which regulate nuclear import and export.The major constituent of the nuclear lamina of Dictyostelium is the lamin NE81. It can form filaments like B-type lamins and it interacts with Sun 1, as well as with the LEM/HeH-family protein Src1. Sun 1 and Src1 are nuclear envelope transmembrane proteins involved in the centrosome-nucleus connection and nuclear envelope stability at the nucleolar regions, respectively. In conjunction with a KASH-domain protein, Sun 1 usually forms a so-called LINC complex.Two proteins with functions reminiscent of KASH-domain proteins at the outer nuclear membrane of Dictyostelium are known; interaptin which serves as an actin connector and the kinesin Kif9 which plays a role in the microtubule-centrosome connector. However, both of these lack the conserved KASH-domain. The link of the centrosome to the nuclear envelope is essential for the insertion of the centrosome into the nuclear envelope and the appropriate spindle formation. Moreover, centrosome insertion is involved in perm eabilization of the mitotic nucleus, which ensures access of tubulin dimers and spindle assembly factors. Our recent progress in identifying key molecular players at the nuclear envelope of Dictyostelium promises further insights into the mechanisms of nuclear envelope dynamics.
The highly conserved enzyme arginyl-tRNA-protein transferase (Ate1) mediates arginylation, a posttranslational modification that is only incompletely understood at its molecular level. To investigate whether arginylation affects actin-dependent processes in a simple model organism, Dictyostelium discoideum, we knocked out the gene encoding Ate1 and characterized the phenotype of ate1-null cells. Visualization of actin cytoskeleton dynamics by live-cell microscopy indicated significant changes in comparison to wild-type cells. Ate1-null cells were almost completely lacking focal actin adhesion sites at the substrate-attached surface and were only weakly adhesive. In two-dimensional chemotaxis assays toward folate or cAMP, the motility of ate1-null cells was increased. However, in three-dimensional chemotaxis involving more confined conditions, the motility of ate1-null cells was significantly reduced. Live-cell imaging showed that GFP-tagged Ate1 rapidly relocates to sites of newly formed actin-rich protrusions. By mass spectrometric analysis, we identified four arginylation sites in the most abundant actin isoform of Dictyostelium, in addition to arginylation sites in other actin isoforms and several actin-binding proteins. In vitro polymerization assays with actin purified from ate1-null cells revealed a diminished polymerization capacity in comparison to wild-type actin. Our data indicate that arginylation plays a crucial role in the regulation of cytoskeletal activities.
Kyub
(2019)
We present an interactive editing system for laser cutting called kyub. Kyub allows users to create models efficiently in 3D, which it then unfolds into the 2D plates laser cutters expect. Unlike earlier systems, such as FlatFitFab, kyub affords construction based on closed box structures, which allows users to turn very thin material, such as 4mm plywood, into objects capable of withstanding large forces, such as chairs users can actually sit on. To afford such sturdy construction, every kyub project begins with a simple finger-joint "boxel"-a structure we found to be capable of withstanding over 500kg of load. Users then extend their model by attaching additional boxels. Boxels merge automatically, resulting in larger, yet equally strong structures. While the concept of stacking boxels allows kyub to offer the strong affordance and ease of use of a voxel-based editor, boxels are not confined to a grid and readily combine with kuyb's various geometry deformation tools. In our technical evaluation, objects built with kyub withstood hundreds of kilograms of loads. In our user study, non-engineers rated the learnability of kyub 6.1/7.
While public–private partnerships (PPPs) have surged worldwide since the 1990s, they have been met with growing skepticism during the last years. A recent revision of Germany’s constitutional rules on motorway construction and observations on the use of PPPs published by both the German and the European Courts of Auditors illustrate this new caution. These two examples fit into a general trend towards a revival of the public sector, which can be summarized under the cross-level umbrella term “publicization.” It would, however, be remiss to replace the uncritical euphoria that once surrounded privatization with a similarly undifferentiated euphoria regarding publicization. Rather, it is crucial to identify the most appropriate solution for the fulfilment of each public task from the “toolbox” of publicization on the one hand and privatization on the other hand in order to ensure the most effective completion of public functions.
The Seismic Hazard Inferred from Tectonics based on the Global Strain Rate Map (SHIFT_GSRM) earthquake forecast was designed to provide high-resolution estimates of global shallow seismicity to be used in seismic hazard assessment. This model combines geodetic strain rates with global earthquake parameters to characterize long-term rates of seismic moment and earthquake activity. Although SHIFT_GSRM properly computes seismicity rates in seismically active continental regions, it underestimates earthquake rates in subduction zones by an average factor of approximately 3. We present a complementary method to SHIFT_GSRM to more accurately forecast earthquake rates in 37 subduction segments, based on the conservation of moment principle and the use of regional interface seismicity parameters, such as subduction dip angles, corner magnitudes, and coupled seismogenic thicknesses. In seven progressive steps, we find that SHIFT_GSRM earthquake-rate underpredictions are mainly due to the utilization of a global probability function of seismic moment release that poorly captures the great variability among subduction megathrust interfaces. Retrospective test results show that the forecast is consistent with the observations during the 1 January 1977 to 31 December 2014 period. Moreover, successful pseudoprospective evaluations for the 1 January 2015 to 31 December 2018 period demonstrate the power of the regionalized earthquake model to properly estimate subduction-zone seismicity.
The interplay between process and decision models plays a crucial role in business process management, as decisions may be based on running processes and affect process outcomes. Often process models include decisions that are encoded through process control flow structures and data flow elements, thus reducing process model maintainability. The Decision Model and Notation (DMN) was proposed to achieve separation of concerns and to possibly complement the Business Process Model and Notation (BPMN) for designing decisions related to process models. Nevertheless, deriving decision models from process models remains challenging, especially when the same data underlie both process and decision models. In this paper, we explore how and to which extent the data modeled in BPMN processes and used for decision-making may be represented in the corresponding DMN decision models. To this end, we identify a set of patterns that capture possible representations of data in BPMN processes and that can be used to guide the derivation of decision models related to existing process models. Throughout the paper we refer to real-world healthcare processes to show the applicability of the proposed approach. (C) 2019 Elsevier Ltd. All rights reserved.
Boron (B) compounds are essential for plants and animals and beneficial for humans in nutritional amounts. I animals and humans increasing evidence have shown beneficial effects on B compounds on nutrition and on antioxidant status. The genotoxic effects of environmental B exposure in women living in boron-rich and boronpoor areas was examined in this study. For this purpose, the DNA damage in the lymphocytes and buccal cells of females were assessed by Comet and micronucleus (MN) assays respectively. No significant difference was observed in the DNA damage of the lymphocytes of B exposed groups of female volunteers in Comet assay. Even buccal micronucleus (MN) frequency observed in the high exposure group was significantly lower than the low exposure group (p < 0.05). The results of this study came to the same conclusions of the previous studies that boron does not induce DNA damage even under extreme exposure conditions.
Veni, vidi, falsi nuntii
(2019)
By adapting the Cheeger-Simons approach to differential cohomology, we establish a notion of differential cohomology with compact support. We show that it is functorial with respect to open embeddings and that it fits into a natural diagram of exact sequences which compare it to compactly supported singular cohomology and differential forms with compact support, in full analogy to ordinary differential cohomology. We prove an excision theorem for differential cohomology using a suitable relative version. Furthermore, we use our model to give an independent proof of Pontryagin duality for differential cohomology recovering a result of [Harvey, Lawson, Zweck - Amer. J. Math. 125 (2003), 791]: On any oriented manifold, ordinary differential cohomology is isomorphic to the smooth Pontryagin dual of compactly supported differential cohomology. For manifolds of finite-type, a similar result is obtained interchanging ordinary with compactly supported differential cohomology.
We present a survey for metal absorption systems traced by neutral oxygen over 3.2 < z < 6.5. Our survey uses Keck/ESI and VLT/X-Shooter spectra of 199 QSOs with redshifts up to 6.6. In total, we detect 74 OI absorbers, of which 57 are separated from the background QSO by more than 5000 km s(-1). We use a maximum likelihood approach to fit the distribution of OI lambda 1302 equivalent widths in bins of redshift and from this determine the evolution in number density of absorbers with W-1302 > 0.05 angstrom, of which there are 49 nonproximate systems in our sample. We find that the number density does not monotonically increase with decreasing redshift, as would naively be expected from the buildup of metal-enriched circumgalactic gas with time. The number density over 4.9 < z < 5.7 is a factor of 1.7-4.1 lower (68% confidence) than that over 5.7 < z < 6.5, with a lower value at z < 5.7 favored with 99% confidence. This decrease suggests that the fraction of metals in a low-ionization phase is larger at z similar to 6 than at lower redshifts. Absorption from highly ionized metals traced by CIV is also weaker in higher-redshift OI systems, supporting this picture. The evolution of OI absorbers implies that metal-enriched circumgalactic gas at z similar to 6 is undergoing an ionization transition driven by a strengthening ultraviolet background. This in turn suggests that the reionization of the diffuse intergalactic medium may still be ongoing at or only recently ended by this epoch.
Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan. We have recently reported a novel acid ceramidase deficiency model that mirrors the human disease closely. Acid sphingomyelinase is the enzyme that generates ceramide upstream of acid ceramidase in the lysosomes. Using our acid ceramidase deficiency model, we tested if acid sphingomyelinase could be a potential novel therapeutic target for the treatment of Farber disease. A number of functional acid sphingomyelinase inhibitors are clinically available and have been used for decades to treat major depression. Using these as a therapeutic for Farber disease, thus, has the potential to improve central nervous symptoms of the disease as well, something all other treatment options for Farber disease can’t achieve so far. As a proof-of-concept study, we first cross-bred acid ceramidase deficient mice with acid sphingomyelinase deficient mice in order to prevent ceramide accumulation. Double-deficient mice had reduced ceramide accumulation, fewer disease manifestations, and prolonged survival. We next targeted acid sphingomyelinase pharmacologically, to test if these findings would translate to a setting with clinical applicability. Surprisingly, the treatment of acid ceramidase deficient mice with the acid sphingomyelinase inhibitor amitriptyline was toxic to acid ceramidase deficient mice and killed them within a few days of treatment. In conclusion, our study provides the first proof-of-concept that acid sphingomyelinase could be a potential new therapeutic target for Farber disease to reduce disease manifestations and prolong survival. However, we also identified previously unknown toxicity of the functional acid sphingomyelinase inhibitor amitriptyline in the context of Farber disease, strongly cautioning against the use of this substance class for Farber disease patients.
We study the spectral location of a strongly pattern equivariant Hamiltonians arising through configurations on a colored lattice. Roughly speaking, two configurations are "close to each other" if, up to a translation, they "almost coincide" on a large fixed ball. The larger this ball, the more similar they are, and this induces a metric on the space of the corresponding dynamical systems. Our main result states that the map which sends a given configuration into the spectrum of its associated Hamiltonian, is Holder (even Lipschitz) continuous in the usual Hausdorff metric. Specifically, the spectral distance of two Hamiltonians is estimated by the distance of the corresponding dynamical systems.
High Harmonic Generation (HHG) is a nonlinear optical process that provides a tunable source for high-energy photons and ultrashort laser pulses. Recent experiments demonstrated that HHG spectroscopy may also be used as an analytical tool to discriminate between randomly oriented configurational isomers of polyatomic organic molecules, namely, between the cis- and trans-forms of 1,2-dichloroethene (DCE) [M. C. H. Wong et al., Phys. Rev. A 84, 051403 (2011)]. Here, we suggest as an economic and at the same time a reasonably accurate method to compute HHG spectra for polyatomic species, Time-Dependent Configuration Interaction Singles (TD-CIS) theory in combination with extended atomic orbital bases and different models to account for ionization losses. The HHG spectra are computed for aligned and unaligned cis- and trans-DCE. For the unaligned case, a coherent averaging over possible rotational orientations is introduced. Furthermore, using TD-CIS, possible differences between the HHG spectra of cis- and trans-DCE are studied. For aligned molecules, spectral differences between cis and trans emerge, which can be related to their different point group symmetries. For unaligned, randomly oriented molecules, we also find distinct HHG spectra in partial agreement with experiment. In addition to HHG response in the frequency space, we compute time-frequency HHG spectra to gain insight into which harmonics are emitted at which time. Further differences between the two isomers emerge, suggesting time-frequency HHG as another tool to discriminate configurational isomers.
Cystine was used as a platform chemical to prepare cyclic and acyclic monomers for entropy-driven ringopening polymerization (ED-ROMP) via olefin or disulfide metathesis and for step-growth polymerization. The olefin ED-ROMP of an olefin/disulfide containing 16-atom macrocycle using the 3rd generation Grubbs catalyst was examined in greater detail. Kinetic studies revealed that the catalyst turned inactive during the polymerization, which limited the achievable (apparent) polymer molar mass to similar to 70 kg mol(-1). Such limitation could be overcome with the disulfide ED-ROMP of the same macrocycle to yield polymers with molar masses of up to 180 kg mol(-1). The step-growth polymerizations of acyclic diene and dithiol monomers via olefin metathesis or oxidation were far less effective and yielded just low molar mass polymers or oligomers; photopolymerization of a thiol-ene monomer produced a polyester with a molar mass of 35 kg mol(-1).
The sedimentary record of the Dead Sea provides an exceptional high-resolution archive of past climate changes in the drought-sensitive eastern Mediterranean-Levant, a key region for the development of humankind at the boundary of global climate belts. Moreover, it is the only deep hypersaline lake known to have deposited long sequences of finely laminated, annually deposited sediments (i.e. varves) of varied compositions, including aragonite, gypsum, halite and clastic sediments. Vast efforts have been made over the years to decipher the environmental information stored in these evaporitic-clastic sequences spanning from the Pleistocene Lake Amora to the Holocene Dead Sea. A general characterisation of sediment facies has been derived from exposed sediment sections, as well as from shallow- and deep-water sediment cores. During high lake stands and episodes of positive water budget, mostly during glacial times, alternating aragonite and detritus laminae (‘aad’ facies) were accumulated, whereas during low lake stands and droughts, prevailing during interglacials, laminated detritus (‘ld’ facies) and laminated halite (‘lh’ facies) dominate the sequence. In this paper, we (i) review the three types of laminated sediments of the Dead Sea sedimentary record (‘aad’, ‘ld’ and ‘lh’ facies), (ii) discuss their modes of formation, deposition and accumulation, and their interpretation as varves, and (iii) illustrate how Dead Sea varves are utilized for palaeoclimate reconstructions and for establishing floating chronologies.
Cross-education has been extensively investigated with adults. Adult studies report asymmetrical cross-education adaptations predominately after dominant limb training. The objective of the study was to examine unilateral leg press (LP) training of the dominant or nondominant leg on contralateral and ipsilateral strength and balance measures. Forty-two youth (10-13 years) were placed (random allocation) into a dominant (n = 15) or nondominant (n = 14) leg press training group or nontraining control (n = 13). Experimental groups trained 3 times per week for 8 weeks and were tested pre-/post-training for ipsilateral and contralateral 1-repetition maximum (RM) horizontal LP, maximum voluntary isometric contraction (MVIC) of knee extensors (KE) and flexors (KF), countermovement jump (CMJ), triple hop test (THT), MVIC strength of elbow flexors (EF) and handgrip, as well as the stork and Y balance tests. Both dominant and nondominant LP training significantly (p < 0.05) increased both ipsilateral and contralateral lower body strength (LP 1RM (dominant: 59.6%-81.8%; nondominant: 59.5%-96.3%), KE MVIC (dominant: 12.4%-18.3%; nondominant: 8.6%-18.6%), KF MVIC (dominant: 7.9%-22.3%; nondominant: nonsignificant-3.8%), and power (CMJ: dominant: 11.1%-18.1%; nondominant: 7.7%-16.6%)). The exception was that nondominant LP training demonstrated a nonsignificant change with the contralateral KF MVIC. Other significant improvements were with nondominant LP training on ipsilateral EF 1RM (6.2%) and THT (9.6%). There were no significant changes with EF and handgrip MVIC. The contralateral leg stork balance test was impaired following dominant LP training. KF MVIC exhibited the only significant relative post-training to pretraining (post-test/pre-test) ratio differences between dominant versus nondominant LP cross-education training effects. In conclusion, children exhibit symmetrical cross-education or global training adaptations with unilateral training of dominant or nondominant upper leg.
The angular size of a star is a critical factor in determining its basic properties1. Direct measurement of stellar angular diameters is difficult: at interstellar distances stars are generally too small to resolve by any individual imaging telescope. This fundamental limitation can be overcome by studying the diffraction pattern in the shadow cast when an asteroid occults a star2, but only when the photometric uncertainty is smaller than the noise added by atmospheric scintillation3. Atmospheric Cherenkov telescopes used for particle astrophysics observations have not generally been exploited for optical astronomy due to the modest optical quality of the mirror surface. However, their large mirror area makes them well suited for such high-time-resolution precision photometry measurements4. Here we report two occultations of stars observed by the Very Energetic Radiation Imaging Telescope Array System (VERITAS)5 Cherenkov telescopes with millisecond sampling, from which we are able to provide a direct measurement of the occulted stars’ angular diameter at the ≤0.1 mas scale. This is a resolution never achieved before with optical measurements and represents an order of magnitude improvement over the equivalent lunar occultation method6. We compare the resulting stellar radius with empirically derived estimates from temperature and brightness measurements, confirming the latter can be biased for stars with ambiguous stellar classifications.
Preparatory mechanisms accompanying or leading to nucleation of larger earthquakes have been observed at both laboratory and field scales, but conditions favoring the occurrence of observable preparatory processes are still largely unknown. In particular, it remains a matter of debate why some earthquakes occur spontaneously without noticeable precursors as opposed to events that are preceded by an extended failure process. In this study, we have generated new high-resolution seismicity catalogs framing the occurrence of 20 M-L > 2.5 earthquakes at The Geysers geothermal field in California. To this end, a seismicity catalog of the 11 days framing each large event was created. We selected 20 sequences sampling different hypocentral depths and hydraulic conditions within the field. Seismic activity and magnitude frequency distributions displayed by the different earthquake sequences are correlated with their location within the reservoir. Sequences located in the northwestern part of the reservoir show overall increased seismic activity and low b values, while the southeastern part is dominated by decreased seismic activity and higher b values. Periods of high injection coincide with high b values and vice versa. These observations potentially reflect varying differential and mean stresses and damage of the reservoir rocks across the field. About 50% of analyzed sequences exhibit no change in seismicity rate in response to the large main event. However, we find complex waveforms at the onset of the main earthquake, suggesting that small ruptures spontaneously grow into or trigger larger events.
The contribution summarises the scientific discussion and research activities of the EGPA Permanent Study Group 4 (PSG 4) “Local Governance and Local Democracy”, founded in 2005. The impetus for proposing this specific PSG was the growing importance of the local level within the multi-level governance system in the European Union and most of its member states. The PSG 4 acts as a European network of research activities inside and outside EGPA, producing joint publications and organising scientific debates on many problems of the development of municipalities and local authorities. Our focus was on discussing both how to improve democracy by increased participation and deliberation, and how to secure provision of services in an efficient way in developed welfare societies. This includes analysing several forms of administrative changes and reforms at the local level and research of representative, direct and cooperative democracy at local level in a cross-European comparison.
X-ray free-electron lasers have, over the past decade, opened up the possibility of understanding the ultrafast response of matter to intense X-ray pulses. In earlier research on atoms and small molecules, new aspects of this response were uncovered, such as rapid sequences of inner-shell photoionization and Auger ionization. Here, we studied a larger molecule, buckminsterfullerene (C-60), exposed to 640 eV X-rays, and examined the role of chemical effects, such as chemical bonds and charge transfer, on the fragmentation following multiple ionization of the molecule. To provide time resolution, we performed femtosecond-resolved X-ray pump/X-ray probe measurements, which were accompanied by advanced simulations. The simulations and experiment reveal that despite substantial ionization induced by the ultrashort (20 fs) X-ray pump pulse, the fragmentation of C-60 is considerably delayed. This work uncovers the persistence of the molecular structure of C-60, which hinders fragmentation over a timescale of hundreds of femtoseconds. Furthermore, we demonstrate that a substantial fraction of the ejected fragments are neutral carbon atoms. These findings provide insights into X-ray free-electron laser-induced radiation damage in large molecules, including biomolecules.
In addition to (bacterio)chlorophylls, (B)Chls, light-harvesting complexes (LHCs) bind carotenoids, and/or their oxygen derivatives, xanthophylls. Xanthophylls/carotenoids have pivotal functions in LHCs: in stabilization of the structure, as accessory light-harvesting pigments and, probably most importantly, in photoprotection. Xanthophylls are assumed to be involved in the not yet fully understood mechanism of energy-dependent (qE) non-photochemical quenching of Chl fluorescence (NPQ) in higher plants and algae. The so called "xanthophyll cycle" appears to be crucial in this regard. The molecular mechanism(s) of xanthophyll involvement in qE/NPQ have not been established, yet. Moreover, excitation energy transfer (EET) processes involving carotenoids are also difficult to study, due to the fact that transitions between the ground state (S-0, 1(1)A(g)(-)) and the lowest excited singlet state (S-1, 2(1)A(g)(-)) of carotenoids are optically one-photon forbidden ("dark"). Two-photon excitation spectroscopic techniques have been used for more than two decades to study one-photon forbidden states of carotenoids. In the current study, two-photon excitation profiles of LHCII samples containing different xanthophyll complements were measured in the presumed 1(1)A(g)(-) -> 2(1)A(g)(-) (S-0 -> S-1) transition spectral region of the xanthophylls, as well as for isolated chlorophylls a and b in solution. The results indicate that direct two-photon excitation of Chls in this spectral region is dominant over that by xanthophylls. Implications of the results for proposed mechanism(s) of qE/NPQ will be discussed.
In biomaterial development, the design of material surfaces that mimic the extra-cellular matrix (ECM) in order to achieve favorable cellular instruction is rather challenging. Collagen-type IV (Col-IV), the major scaffolding component of Basement Membranes (BM), a specialized ECM with multiple biological functions, has the propensity to form networks by self-assembly and supports adhesion of cells such as endothelial cells or stem cells. The preparation of biomimetic Col-IV network-like layers to direct cell responses is difficult. We hypothesize that the morphology of the layer, and especially the density of the available adhesion sites, regulates the cellular adhesion to the layer. The Langmuir monolayer technique allows for preparation of thin layers with precisely controlled packing density at the air-water (A-W) interface. Transferring these layers onto cell culture substrates using the Langmuir-Schafer (LS) technique should therefore provide a pathway for preparation of BM mimicking layers with controlled cell adherence properties. In situ characterization using ellipsometry and polarization modulation-infrared reflection absorption spectroscopy of Col-IV layer during compression at the A-W interface reveal that there is linear increase of surface molecule concentration with negligible orientational changes up to a surface pressure of 25 mN m(-1). Smooth and homogeneous Col-IV network-like layers are successfully transferred by LS method at 15 mN m(-1) onto poly(ethylene terephthalate) (PET), which is a common substrate for cell culture. In contrast, the organization of Col-IV on PET prepared by the traditionally employed solution deposition method results in rather inhomogeneous layers with the appearance of aggregates and multilayers. Progressive increase in the number of early adherent mesenchymal stem cells (MSCs) after 24 h by controlling the areal Col-IV density by LS transfer at 10, 15 and 20 mN m(-1) on PET is shown. The LS method offers the possibility to control protein characteristics on biomaterial surfaces such as molecular density and thereby, modulate cell responses.
Movement ecology aims to provide common terminology and an integrative framework of movement research across all groups of organisms. Yet such work has focused on unitary organisms so far, and thus the important group of filamentous fungi has not been considered in this context. With the exception of spore dispersal, movement in filamentous fungi has not been integrated into the movement ecology field. At the same time, the field of fungal ecology has been advancing research on topics like informed growth, mycelial translocations, or fungal highways using its own terminology and frameworks, overlooking the theoretical developments within movement ecology. We provide a conceptual and terminological framework for interdisciplinary collaboration between these two disciplines, and show how both can benefit from closer links: We show how placing the knowledge from fungal biology and ecology into the framework of movement ecology can inspire both theoretical and empirical developments, eventually leading towards a better understanding of fungal ecology and community assembly. Conversely, by a greater focus on movement specificities of filamentous fungi, movement ecology stands to benefit from the challenge to evolve its concepts and terminology towards even greater universality. We show how our concept can be applied for other modular organisms (such as clonal plants and slime molds), and how this can lead towards comparative studies with the relationship between organismal movement and ecosystems in the focus.
Selfish Network Creation focuses on modeling real world networks from a game-theoretic point of view. One of the classic models by Fabrikant et al. (2003) is the network creation game, where agents correspond to nodes in a network which buy incident edges for the price of alpha per edge to minimize their total distance to all other nodes. The model is well-studied but still has intriguing open problems. The most famous conjectures state that the price of anarchy is constant for all alpha and that for alpha >= n all equilibrium networks are trees. We introduce a novel technique for analyzing stable networks for high edge-price alpha and employ it to improve on the best known bound for the latter conjecture. In particular we show that for alpha > 4n - 13 all equilibrium networks must be trees, which implies a constant price of anarchy for this range of alpha. Moreover, we also improve the constant upper bound on the price of anarchy for equilibrium trees.
We derive a set of regional ground-motion prediction equations (GMPEs) in the Fourier amplitude spectra (FAS-GMPE) and in the spectral acceleration (SA-GMPE) domains for the purpose of interpreting the between-event residuals in terms of source parameter variability. We analyze a dataset of about 65,000 recordings generated by 1400 earthquakes (moment magnitude 2: 5 <= M-w <= 6: 5, hypocentral distance R-hypo <= 150 km) that occurred in central Italy between January 2008 and October 2017. In a companion article (Bindi, Spallarossa, et al., 2018), the nonparametric acceleration source spectra were interpreted in terms of omega-square models modified to account for deviations from a high-frequency flat plateau through a parameter named k(source). Here, the GMPEs are derived considering the moment (M-w), the local (M-L), and the energy (M-e) magnitude scales, and the between-event residuals are computed as random effects. We show that the between-event residuals for the FAS-GMPE implementing M-w are correlated with stress drop, with correlation coefficients increasing with increasing frequency up to about 10 Hz. Contrariwise, the correlation is weak for the FAS-GMPEs implementing M-L and M-e, in particular between 2 and 5 Hz, where most of the corner frequencies lie. At higher frequencies, all models show a strong correlation with k(source). The correlation with the source parameters reflects in a different behavior of the standard deviation tau of the between-event residuals with frequency. Although tau is smaller for the FAS-GMPE using M-w below 1.5 Hz, at higher frequencies, the model implementing either M-L or M-e shows smaller values, with a reduction of about 30% at 3 Hz (i.e., from 0.3 for M-w to 0.1 for M-L). We conclude that considering magnitude scales informative for the stress-drop variability allows to reduce the between-event variability with a significant impact on the hazard assessment, in particular for studies in which the ergodic assumption on site is removed.
Rapidly changing climate in the Northern Hemisphere and associated socio-economic impacts require reliable understanding of lake systems as important freshwater resources and sensitive sentinels of environmental change. To better understand time-series data in lake sediment cores, it is necessary to gain information on within-lake spatial variabilities of environmental indicator data. Therefore, we retrieved a set of 38 samples from the sediment surface along spatial habitat gradients in the boreal, deep, and yet pristine Lake Bolshoe Toko in southern Yakutia, Russia. Our methods comprise laboratory analyses of the sediments for multiple proxy parameters, including diatom and chironomid taxonomy, oxygen isotopes from diatom silica, grain-size distributions, elemental compositions (XRF), organic carbon content, and mineralogy (XRD). We analysed the lake water for cations, anions, and isotopes. Our results show that the diatom assemblages are strongly influenced by water depth and dominated by planktonic species, i.e. Pliocaenicus bolshetokoensis. Species richness and diversity are higher in the northern part of the lake basin, associated with the availability of benthic, i.e. periphytic, niches in shallower waters. delta O-18(diatom) values are higher in the deeper south-western part of the lake, probably related to water temperature differences. The highest amount of the chironomid taxa underrepresented in the training set used for palaeoclimate inference was found close to the Utuk River and at southern littoral and profundal sites. Abiotic sediment components are not symmetrically distributed in the lake basin, but vary along restricted areas of differential environmental forcing. Grain size and organic matter are mainly controlled by both river input and water depth. Mineral (XRD) data distributions are influenced by the methamorphic lithology of the Stanovoy mountain range, while elements (XRF) are intermingled due to catchment and diagenetic differences. We conclude that the lake represents a valuable archive for multiproxy environmental reconstruction based on diatoms (including oxygen isotopes), chironomids, and sediment-geochemical parameters. Our analyses suggest multiple coring locations preferably at intermediate depth in the northern basin and the deep part in the central basin, to account for representative bioindicator distributions and higher temporal resolution, respectively.
Permafrost warming has the potential to amplify global climate change, because when frozen sediments thaw it unlocks soil organic carbon. Yet to date, no globally consistent assessment of permafrost temperature change has been compiled. Here we use a global data set of permafrost temperature time series from the Global Terrestrial Network for Permafrost to evaluate temperature change across permafrost regions for the period since the International Polar Year (2007-2009). During the reference decade between 2007 and 2016, ground temperature near the depth of zero annual amplitude in the continuous permafrost zone increased by 0.39 +/- 0.15 degrees C. Over the same period, discontinuous permafrost warmed by 0.20 +/- 0.10 degrees C. Permafrost in mountains warmed by 0.19 +/- 0.05 degrees C and in Antarctica by 0.37 +/- 0.10 degrees C. Globally, permafrost temperature increased by 0.29 +/- 0.12 degrees C. The observed trend follows the Arctic amplification of air temperature increase in the Northern Hemisphere. In the discontinuous zone, however, ground warming occurred due to increased snow thickness while air temperature remained statistically unchanged.
We obtain a Bernstein-type inequality for sums of Banach-valued random variables satisfying a weak dependence assumption of general type and under certain smoothness assumptions of the underlying Banach norm. We use this inequality in order to investigate in the asymptotical regime the error upper bounds for the broad family of spectral regularization methods for reproducing kernel decision rules, when trained on a sample coming from a tau-mixing process.
Predator-prey cycles rank among the most fundamental concepts in ecology, are predicted by the simplest ecological models and enable, theoretically, the indefinite persistence of predator and prey(1-4). However, it remains an open question for how long cyclic dynamics can be self-sustained in real communities. Field observations have been restricted to a few cycle periods(5-8) and experimental studies indicate that oscillations may be short-lived without external stabilizing factors(9-19). Here we performed microcosm experiments with a planktonic predator-prey system and repeatedly observed oscillatory time series of unprecedented length that persisted for up to around 50 cycles or approximately 300 predator generations. The dominant type of dynamics was characterized by regular, coherent oscillations with a nearly constant predator-prey phase difference. Despite constant experimental conditions, we also observed shorter episodes of irregular, non-coherent oscillations without any significant phase relationship. However, the predator-prey system showed a strong tendency to return to the dominant dynamical regime with a defined phase relationship. A mathematical model suggests that stochasticity is probably responsible for the reversible shift from coherent to non-coherent oscillations, a notion that was supported by experiments with external forcing by pulsed nutrient supply. Our findings empirically demonstrate the potential for infinite persistence of predator and prey populations in a cyclic dynamic regime that shows resilience in the presence of stochastic events.
The northward indentation of the Pamir salient into the Tarim basin at the western syntaxis of the India-Asia collision zone is the focus of controversial models linking lithospheric to surface and atmospheric processes. Here we report on tectonic events recorded in the most complete and best-dated sedimentary sequences from the western Tarim basin flanking the eastern Pamir (the Aertashi section), based on sedimentologic, provenance, and magnetostratigraphic analyses. Increased tectonic subsidence and a shift from marine to continental fluvio-deltaic deposition at 41Ma indicate that far-field deformation from the south started to affect the Tarim region. A sediment accumulation hiatus from 24.3 to 21.6Ma followed by deposition of proximal conglomerates is linked to fault propagation into the Tarim basin. From 21.6 to 15.0Ma, increasing accumulation rates of fining upward clastics is interpreted as the expression of a major dextral transtensional system linking the Kunlun to the Tian Shan ahead of the northward Pamir indentation. At 15.0Ma, the appearance of North Pamir-sourced conglomerates followed at 11Ma by Central Pamir-sourced volcanics coincides with a shift to E-W compression, clockwise vertical-axis rotations and the onset of growth strata associated with the activation of the local east vergent Qimugen thrust wedge. Together, this enables us to interpret that Pamir indentation into Tarim had started by 24.3Ma, reached the study location by 15.0Ma and had passed it by 11Ma, providing kinematic constraints on proposed tectonic models involving intracontinental subduction and delamination.
More than Walls
(2019)
If Germany and Europe turned their attention to Latin America, they could extend the transatlantic partnership by adding new partners and focussing on new issues without breaking ties with Washington. However, the countries of the region have differing views of Europe. Mexico is a special case in Latin America because of its close ties with the US, and the economic, political, and strategic interests that it shares with Europe. There is a need for Europe and the US to work together more closely in order to counterbalance China’s growing influence.
We investigate an intermittent stochastic process in which the diffusive motion with time-dependent diffusion coefficient D(t)∼tα−1 with α>0 (scaled Brownian motion) is stochastically reset to its initial position, and starts anew. In the present work we discuss the situation in which the memory on the value of the diffusion coefficient at a resetting time is erased, so that the whole process is a fully renewal one. The situation when the resetting of the coordinate does not affect the diffusion coefficient's time dependence is considered in the other work of this series [A. S. Bodrova et al., Phys. Rev. E 100, 012119 (2019)]. We show that the properties of the probability densities in such processes (erasing or retaining the memory on the diffusion coefficient) are vastly different. In addition we discuss the first-passage properties of the scaled Brownian motion with renewal resetting and consider the dependence of the efficiency of search on the parameters of the process.
We investigate an intermittent stochastic process in which diffusive motion with a time-dependent diffusion coefficient, D(t)∼tα−1, α>0 (scaled Brownian motion), is stochastically reset to its initial position and starts anew. The resetting follows a renewal process with either an exponential or a power-law distribution of the waiting times between successive renewals. The resetting events, however, do not affect the time dependence of the diffusion coefficient, so that the whole process appears to be a nonrenewal one. We discuss the mean squared displacement of a particle and the probability density function of its positions in this process. We show that scaled Brownian motion with resetting demonstrates rich behavior whose properties essentially depend on the interplay of the parameters of the resetting process and the particle's displacement infree motion. The motion of particles can remain almost unaffected by resetting but can also get slowed down or even be completely suppressed. Especially interesting are the nonstationary situations in which the mean squared displacement stagnates but the distribution of positions does not tend to any steady state. This behavior is compared to the situation [discussed in the companion paper; A. S. Bodrova et al., Phys. Rev. E 100, 012120 (2019)] in which the memory of the value of the diffusion coefficient at a resetting time is erased, so that the whole process is a fully renewal one. We show that the properties of the probability densities in such processes (erasing or retaining the memory on the diffusion coefficient) are vastly different.
Climatic observables are often correlated across long spatial distances, and extreme events, such as heatwaves or floods, are typically assumed to be related to such teleconnections(1,2). Revealing atmospheric teleconnection patterns and understanding their underlying mechanisms is of great importance for weather forecasting in general and extreme-event prediction in particular(3,4), especially considering that the characteristics of extreme events have been suggested to change under ongoing anthropogenic climate change(5-8). Here we reveal the global coupling pattern of extreme-rainfall events by applying complex-network methodology to high-resolution satellite data and introducing a technique that corrects for multiple-comparison bias in functional networks. We find that the distance distribution of significant connections (P < 0.005) around the globe decays according to a power law up to distances of about 2,500 kilometres. For longer distances, the probability of significant connections is much higher than expected from the scaling of the power law. We attribute the shorter, power-law-distributed connections to regional weather systems. The longer, super-power-law-distributed connections form a global rainfall teleconnection pattern that is probably controlled by upper-level Rossby waves. We show that extreme-rainfall events in the monsoon systems of south-central Asia, east Asia and Africa are significantly synchronized. Moreover, we uncover concise links between south-central Asia and the European and North American extratropics, as well as the Southern Hemisphere extratropics. Analysis of the atmospheric conditions that lead to these teleconnections confirms Rossby waves as the physical mechanism underlying these global teleconnection patterns and emphasizes their crucial role in dynamical tropical-extratropical couplings. Our results provide insights into the function of Rossby waves in creating stable, global-scale dependencies of extreme-rainfall events, and into the potential predictability of associated natural hazards.
Academic Achievement in Math and Foreign Language: Individual Characteristics and Gender Stereotypes
(2019)
The study aims to investigate the contribution of individual characteristics and gender stereotypes of secondary school pupils in academic achievement in math and foreign language. A sample of pupils reported in 6th and 7th grades (three waves) their self-perceived ability and motivation for math and foreign language learning, math and foreign language gender stereotypes, implicit theories of intelligence; academic achievement (grades) in math in foreign language is also included in the analysis. Regression analysis and Mann Whitney U Test demonstrated that self-perceived ability in math and incremental theory of intelligence are significant predictors for academic achievement in maths. Boys are characterised by higher level of self-perceived abilities and motivation for learning math. However, academic achievement of girls in maths and foreign languages are higher as compared to boys. Pupils learning two foreign languages demonstrate higher level of self-perceived abilities for motivation and learning math and less expressed gender stereotypes about success in learning math and foreign languages. Study findings can be used for designing educational programmes for mathematics and foreign languages, professional development and finding solutions for individualized approach in school education.
We explore electron preacceleration at high-Mach-number nonrelativistic perpendicular shocks at, e.g., young supernova remnants, which are a prerequisite of further acceleration to very high energies via diffusive shock acceleration. Using fully kinetic particle-in-cell simulations of shocks and electron dynamics in them, we investigate the influence of shock-surfing acceleration (SSA) at the shock foot on the nonthermal population of electrons downstream of the shock. The SSA is followed by further energization at the shock ramp where the Weibel instability spawns a type of second-order Fermi acceleration. The combination of these two processes leads to the formation of a nonthermal electron population, but the importance of SSA becomes smaller for larger ion-to-electron mass ratios in the simulation. We discuss the resulting electron spectra and the relevance of our results to the physics of systems with real ion-to-electron mass ratios and fully three-dimensional behavior.
Electron injection at high Mach number nonrelativistic perpendicular shocks is studied here for parameters that are applicable to young SNR shocks. Using high-resolution large-scale two-dimensional fully kinetic particle-in-cell simulations and tracing individual particles, we in detail analyze the shock-surfing acceleration (SSA) of electrons at the leading edge of the shock foot. The central question is to what degree the process can be captured in 2D3V simulations. We find that the energy gain in SSA always arises from the electrostatic field of a Buneman wave. Electron energization is more efficient in the out-of-plane orientation of the large-scale magnetic field because both the phase speed and the amplitude of the waves are higher than for the in-plane scenario. Also, a larger number of electrons is trapped by the waves compared to the in-plane configuration. We conclude that significant modifications of the simulation parameters are needed to reach the same level of SSA efficiency as in simulations with out-of-plane magnetic field or 3D simulations.
The concurrent performance of cognitive and postural tasks is particularly impaired in old adults and associated with an increased risk of falls. Biological aging of the cognitive and postural control system appears to be responsible for increased cognitive-motor interference effects. We examined neural and behavioral markers of motor-cognitive dual-task performance in young and old adults performing spatial one-back working memory single and dual tasks during semitandem stance. On the neural level, we used EEG to test for age-related modulations in the frequency domain related to cognitive-postural task load. Twenty-eight healthy young and 30 old adults participated in this study. The tasks included a postural single task, a cognitive-postural dual task, and a cognitive-postural triple task (cognitive dual-task with postural demands). Postural sway (i.e., total center of pressure displacements) was recorded in semistance position on an unstable surface that was placed on top of a force plate while performing cognitive tasks. Neural activation was recorded using a 64-channel mobile EEG system. EEG frequencies were attenuated by the baseline postural single-task condition and demarcated in nine Regions-of-Interest (ROIs), i.e., anterior, central, posterior, over the cortical midline, and both hemispheres. Our findings revealed impaired cognitive dual-task performance in old compared to young participants in the form of significantly lower cognitive performance in the triple-task condition. Furthermore, old adults compared with young adults showed significantly larger postural sway, especially in cognitive-postural task conditions. With respect to EEG frequencies, young compared to old participants showed significantly lower alpha-band activity in cognitive-cognitive-postural triple-task conditions compared with cognitive-postural dual tasks. In addition, with increasing task difficulty, we observed synchronized theta and delta frequencies, irrespective of age. Taskdependent alterations of the alpha frequency band were most pronounced over frontal and central ROIs, while alterations of the theta and delta frequency bands were found in frontal, central, and posterior ROIs. Theta and delta synchronization exhibited a decrease from anterior to posterior regions. For old adults, task difficulty was reflected by theta synchronization in the posterior ROI. For young adults, it was reflected by alpha desynchronization in bilateral anterior ROIs. In addition, we could not identify any effects of task difficulty and age on the beta frequency band. Our results shed light on age-related cognitive and postural declines and how they interact. Modulated alpha frequencies during high cognitive-postural task demands in young but not old adults might be reflective of a constrained neural adaptive potential in old adults. Future studies are needed to elucidate associations between the identified age-related performance decrements with task difficulty and changes in brain activity.
Measuring (dis)similarity between ecosystem states is a key theme in ecology. Much of community and ecosystem ecology is devoted to searching for patterns in ecosystem similarity from an external observer's viewpoint, using variables such as species abundances, measures of diversity and complexity. However, from the point of view of organisms in the ecosystem, proportional population growth rates are the only relevant aspect of ecosystem state, because natural selection acts on groups of organisms with different proportional population growth rates. We therefore argue that two ecosystem states are equivalent if and only if, for each species they contain, the proportional population growth rate does not differ between the states. Based on this result, we develop species-level and aggregated summary measures of ecosystem state and discuss their ecological meaning. We illustrate our approach using a long-term dataset on the plankton community from the Central European Lake Constance. We show that the first three principal components of proportional population growth rates describe most of the variation in ecosystem state in Lake Constance. We strongly recommend using proportional population growth rates and the derived equivalence classes for comparative ecosystem studies. This opens up new perspectives on important existing topics such as alternative stable ecosystem states, community assembly, and the processes generating regularities in ecosystems.
We study the dynamics of the ring of identical phase oscillators with nonlinear nonlocal coupling. Using the Ott - Antonsen approach, the problem is formulated as a system of partial derivative equations for the local complex order parameter. In this framework, we investigate the existence and stability of twisted states. Both fully coherent and partially coherent stable twisted states were found (the latter ones for the first time for identical oscillators). We show that twisted states can be stable starting from a certain critical value of the medium length, or on a length segment. The analytical results are confirmed with direct numerical simulations in finite ensembles.
Although there is ample evidence linking insecure attachment styles and intimate partner violence (IPV), little is known about the psychological processes underlying this association, especially from the victim’s perspective. The present study examined how attachment styles relate to the experience of sexual and psychological abuse, directly or indirectly through destructive conflict resolution strategies, both self-reported and attributed to their opposite-sex romantic partner. In an online survey, 216 Spanish undergraduates completed measures of adult attachment style, engagement and withdrawal conflict resolution styles shown by self and partner, and victimization by an intimate partner in the form of sexual coercion and psychological abuse. As predicted, anxious and avoidant attachment styles were directly related to both forms of victimization. Also, an indirect path from anxious attachment to IPV victimization was detected via destructive conflict resolution strategies. Specifically, anxiously attached participants reported a higher use of conflict engagement by themselves and by their partners. In addition, engagement reported by the self and perceived in the partner was linked to an increased probability of experiencing sexual coercion and psychological abuse. Avoidant attachment was linked to higher withdrawal in conflict situations, but the paths from withdrawal to perceived partner engagement, sexual coercion, and psychological abuse were non-significant. No gender differences in the associations were found. The discussion highlights the role of anxious attachment in understanding escalating patterns of destructive conflict resolution strategies, which may increase the vulnerability to IPV victimization.
The relationships between sedentary lifestyle, sitting behaviour, and low back pain (LBP) remain controversial. In this study, we investigated the relationship between back pain and occupational sitting habits in 64 call-centre employees. A textile pressure mat was used to evaluate and parameterise sitting behaviour over a total of 400 h, while pain questionnaires evaluated acute and chronic LBP. Seventy-five percent of the participants reported some level of either chronic or acute back pain. Individuals with chronic LBP demonstrated a possible trend (t-test not significant) towards more static sitting behaviour compared to their pain-free counterparts. Furthermore, a greater association was found between sitting behaviour and chronic LBP than for acute pain/disability, which is plausibly due to a greater awareness of pain-free sitting positions in individuals with chronic pain compared to those affected by acute pain.
Adjustment of median ground motion prediction equations (GMPEs) from one region to another region is one of the major challenges within the current practice of seismic hazard analysis. In our approach of generating response spectra, we derive two separate empirical models for a) Fourier amplitude spectrum (FAS) and b) duration of ground motion. To calculate response spectra, the two models are combined within the random vibration theory (RVT) framework. The models are calibrated on recordings obtained from shallow crustal earthquakes in active tectonic regions. We use a subset of NGA-West2 database with M3.2-7.9 earthquakes at distances 0-300 km. The NGA-West2 database expanded over a wide magnitude and distance range facilitates a better constraint over derived models. A frequency-dependent duration model is derived to obtain adjustable response spectral ordinates. Excellent comparison of our approach with other NGA-West2 models implies that it can also be used as a stand-alone model.
This paper studies the effect of public transport policies on urban pollution. It uses a quantitative equilibrium model with residential choice and mode choice. Pollution comes from commuting and residential energy use. The model parameters are calibrated to replicate key variables for American metropolitan areas. In the counterfactual, I study how free public transport coupled with increasing transit speed affects the equilibrium. In the baseline simulation, total pollution falls by 0.4%, as decreasing emissions from transport are partly offset by rising residential emissions. A second counterfactual compares a city with and without public transit. This large investment decreases pollution by 1.7%. When jobs are decentralized, emissions fall by 0.5% in the first and by 3% in the second counterfactual.
Is urbanization good for the environment? This paper establishes a simple core-periphery model with monocentric cities, which comprises key forces that shape the structure and interrelation of cities to study the impact of the urban evolution on the environment. We focus on global warming and the potential of unfettered market forces to economize on emissions. The model parameters are chosen to match the dichotomy between average "large" and "small" cities in the urban geography of the United States, and the sectoral greenhouse gas emissions recorded for the United States. Based on numerical analyzes we find that a forced switch to a system with equally sized cities reduces total emissions. Second, any city driver which pronounces the asymmetry between the core and the periphery drives up emissions in the total city system, too, and the endogenous adjustment of the urban system accounts for the bulk of the change in emissions. Third, none of the city drivers gives rise to an urban environmental Kuznets curve according to our numerical simulations. Finally, the welfare-maximizing allocation tends to involve dispersion of cities and the more so the higher is the marginal damage from pollution.
We study optimal and equilibrium sizes of cities in a city system model with pollution. Pollution is a function of population size. If pollution is local or per-capita pollution increases with population, equilibrium cities are too large under symmetry; with asymmetric cities, the largest cities are too large and the smallest too small. When pollution is global and per-capita pollution declines with city size, cities may be too small under symmetry; with asymmetric cities, the largest cities are too small and the smallest too large if the marginal damage of pollution is large enough. We calibrate the model to US cities and find that the largest cities may be undersized by 3-4%.
Garnet of eclogite (formerly termed garnet clinopyroxenite) hosted in lenses of orogenic garnet peridotite from the Granulitgebirge, NW Bohemian Massif, contains unique inclusions of granitic melt, now either glassy or crystallized. Analysed glasses and re‐homogenized inclusions are hydrous, peraluminous, and enriched in highly incompatible elements characteristic of the continental crust such as Cs, Li, B, Pb, Rb, Th, and U. The original melt thus represents a pristine, chemically evolved metasomatic agent, which infiltrated the mantle via deep continental subduction during the Variscan orogeny. The bulk chemical composition of the studied eclogites is similar to that of Fe‐rich basalt and the enrichment in LILE and U suggest a subduction‐related component. All these geochemical features confirm metasomatism. In comparison with many other garnet+clinopyroxene‐bearing lenses in peridotites of the Bohemian Massif, the studied samples from Rubinberg and Klatschmühle are more akin to eclogite than pyroxenites, as reflected in high jadeite content in clinopyroxene, relatively low Mg, Cr, and Ni but relatively high Ti. However, trace elements of both bulk rock and individual mineral phases show also important differences making these samples rather unique. Metasomatism involving a melt requiring a trace element pattern very similar to the composition reported here has been suggested for the source region of rocks of the so‐called durbachite suite, that is, ultrapotassic melanosyenites, which are found throughout the high‐grade Variscan basement. Moreover, the Th, U, Pb, Nb, Ta, and Ti patterns of these newly studied melt inclusions (MI) strongly resemble those observed for peridotite and its enclosed pyroxenite from the T‐7 borehole (Staré, České Středhoři Mountains) in N Bohemia. This suggests that a similar kind of crustal‐derived melt also occurred here. This study of granitic MI in eclogites from peridotites has provided the first direct characterization of a preserved metasomatic melt, possibly responsible for the metasomatism of several parts of the mantle in the Variscides.
Intra-organ communication guides morphogenetic processes that are essential for an organ to carry out complex physiological functions. In the heart, the growth of the myocardium is tightly coupled to that of the endocardium, a specialized endothelial tissue that lines its interior. Several molecular pathways have been implicated in the communication between these tissues including secreted factors, components of the extracellular matrix, or proteins involved in cell-cell communication. Yet, it is unknown how the growth of the endocardium is coordinated with that of the myocardium. Here, we show that an increased expansion of the myocardial atrial chamber volume generates higher junctional forces within endocardial cells. This leads to biomechanical signaling involving VE-cadherin, triggering nuclear localization of the Hippo pathway transcriptional regulator Yap1 and endocardial proliferation. Our work suggests that the growth of the endocardium results from myocardial chamber volume expansion and ends when the tension on the tissue is relaxed.
The nematode Caenorhabditis elegans (C. elegans) is often used as an alternative animal model due to several advantages such as morphological changes that can be seen directly under a microscope. Limitations of the model include the usage of expensive and cumbersome microscopes, and restrictions of the comprehensive use of C. elegans for toxicological trials. With the general applicability of the detection of C. elegans from microscope images via machine learning, as well as of smartphone-based microscopes, this article investigates the suitability of smartphone-based microscopy to detect C. elegans in a complete Petri dish. Thereby, the article introduces a smartphone-based microscope (including optics, lighting, and housing) for monitoring C. elegans and the corresponding classification via a trained Histogram of Oriented Gradients (HOG) feature-based Support Vector Machine for the automatic detection of C. elegans. Evaluation showed classification sensitivity of 0.90 and specificity of 0.85, and thereby confirms the general practicability of the chosen approach.
This study addresses the question of how age of acquisition (AoA) affects grammatical processing, specifically with respect to inflectional morphology, in bilinguals. We examined experimental data of more than 100 participants from the Russian/German community in Berlin, all of whom acquired Russian from birth and German at different ages. Using the cross-modal lexical priming technique, we investigated stem allomorphs of German verbs that encode multiple morphosyntactic features. The results revealed a striking AoA modulation of observed priming patterns, indicating efficient access to morphosyntactic features for early AoAs and a gradual decline with increasing AoAs. In addition, we found a discontinuity in the function relating AoA to morphosyntactic feature access, suggesting a sensitive period for the development of morphosyntax.
We present a quantum-mechanical tier model for vibrational relaxation of low-lying excited states of an adsorbate vibrational mode (system), coupled to surface phonons (bath), at zero temperature. The tier model, widely used in studies of intramolecular vibrational energy redistribution in polyatomics, is adapted here to adsorbate-surface systems with the help of an embedded cluster approach, using orthogonal coordinates for the system and bath modes, and a phononic expansion of their interaction. The key idea of the model is to organize the system-bath zeroth-order vibrational space into a hierarchical structure of vibrational tiers and keep therein only vibrational states that are sequentially generated from the system-bath initial vibrational state. Each tier is generated from the previous one by means of a successor operator, derived from the system-bath interaction Hamiltonian. This sequential procedure leads to a drastic reduction of the dimension of the system-bath vibrational space. We notably show that for harmonic vibrational motion of the system and linear system-bath couplings in the system coordinate, the dimension of the tier-model vibrational basis scales as similar to N-lxv. Here, N is the number of bath modes, l is the highest-order of the phononic expansion, and l is the size of the system vibrational basis. This polynomial scaling is computationally far superior to the exponential scaling of the original zeroth-order vibrational basis, similar to M-N, with M being the number of basis functions per bath mode. In addition, since each tier is coupled only to its adjacent neighbors, the matrix representation of the system-bath Hamiltonian in this new vibrational basis has a symmetric block-tridiagonal form, with each block being very sparse. This favors the combination of the tier-model with iterative Krylov techniques, such as the Lanczos algorithm, to solve the time-dependent Schrodinger equation for the full Hamiltonian. To illustrate the method, we study vibrational relaxation of a D-Si bending mode, coupled via two-and (mainly) one-phonon interactions to a fully D-covered Si(100)-(2 x 1) surface, using a recent first-principles system-bath Hamiltonian. The results of the tier model are compared with those obtained by the Lindblad formalism of the reduced density matrix. We find that the tier model provides much more information and insight into mechanisms of vibration-phonon couplings at surfaces, and gives more reliable estimates of the adsorbate vibrational lifetimes. Moreover, the tier model might also serve as a benchmark for other approximate quantum-dynamics methods, such as multiconfiguration wavefunction approaches. Published under license by AIP Publishing.
Suboptimal post-operative improvements in functional capacity are often observed after minimally invasive aortic valve replacement (mini-AVR). It remains to be studied how AVR affects the cardiopulmonary and skeletal muscle function during exercise to explain these clinical observations and to provide a basis for improved/tailored post-operative rehabilitation. Twenty two patients with severe aortic stenosis (AS) (aortic valve area (AVA) < 1.0 cm(2)) were preoperatively compared to 22 healthy controls during submaximal constant-workload endurance-type exercise for oxygen uptake (V-O2), carbon dioxide output (V-CO2), respiratory gas exchange ratio, expiratory volume (V-E), ventilatory equivalents for O-2 (V-E/V-O2) and CO2 (V-E/V-CO2), respiratory rate (RR), tidal volume (V-t), heart rate (HR), oxygen pulse (V-O2/HR), blood lactate, Borg ratings of perceived exertion (RPE) and exercise-onset V-O2 kinetics. These exercise tests were repeated at 5 and 21 days after AVR surgery (n = 14), along with echocardiographic examinations. Respiratory exchange ratio and ventilatory equivalents (V-E/V-O2 and V-E/V-CO2) were significantly elevated, V-O2 and V-O2/HR were significantly lowered, and exercise-onset V-O2 kinetics were significantly slower in AS patients vs. healthy controls (P < 0.05). Although the AVA was restored by mini-AVR in AS patients, V-E/V-O2 and V-E/V-CO2 further worsened significantly within 5 days after surgery, accompanied by elevations in Borg RPE, V-E and RR, and lowered V-t. At 21 days after mini-AVR, exercise-onset V-O2 kinetics further slowed significantly (P < 0.05). A decline in pulmonary function was observed early aftermini-AVRsurgery, which was followed by a decline in skeletal muscle function in the subsequent weeks of recovery. Therefore, a tailored rehabilitation programmeshould include training modalities for the respiratory and peripheral muscular system.
Aims. We investigated the ionisation conditions and distances of Galactic high-velocity clouds (HVCs) in the Galactic halo and beyond in the direction of the Local Group (LG) barycentre and anti-barycentre, by studying spectral data of 29 extragalactic background sources obtained with the Cosmic Origins Spectropgraph (COS) installed on the Hubble Space Telescope (HST). Methods. We model column-densities of low, intermediate, and high ions such as Si ii, C ii, Si iii, Si vi, and C iv, and use these data to construct a set of Cloudy ionisation models. Results. In total, we found 69 high-velocity absorption components along the 29 lines of sight. The components in the direction of the LG barycentre span the entire range of studied velocities, 100 less than or similar to vertical bar nu(LSR)vertical bar less than or similar to 400 km s(-1), while those in the anti-barycentre sample have velocities up to about 300 km s(-1). For 49 components, we infer the gas densities. In the direction of the LG barycentre, the gas densities exhibit a wide range from log nH = -3.96 to -2.55, while in the anti-barycentre direction the densities are systematically higher, log nH > -3.25. The barycentre absorbers can be split into two groups based on their density: a high-density group with log nH > -3.54, which can be affected by the Milky Way radiation field, and a low-density group (log nH <= -3.54). The latter has very low thermal pressures of P/k < 7.3 Kcm(-3). Conclusions. Our study shows that part of the absorbers in the LG barycentre direction trace gas at very low gas densities and thermal pressures. These properties indicate that the absorbers are located beyond the virial radius of the Milky Way. Our study also confirms results from earlier, single-sightline studies, suggesting the presence of a metal-enriched intragroup medium filling the LG near its barycentre.
From waste to resource
(2019)
Reservoir networks have been established worldwide to ensure water supply, but water availability is endangered quantitatively and qualitatively by sedimentation. Reuse of sediment silted in reservoirs as fertilizer has been proposed, thus transforming nutrient-enriched sediments from waste into resource. The aim of this study is to assess the potential of reusing sediment as a nutrient source for agriculture a semiarid basin in Brazil. where 1029 reservoirs were identified. Sedimentation was modelled for the entire reservoir network, accounting for 7 x 10(5) tons of y(-1)sediment deposition. Nutrients contents in reservoir sediments was analysed and com- pared to nutrients contents of agricultural soils in the catchment. The potential of reusing sediment as fertilizer was assessed for maize crops (Zea mays L) and the sediment mass required to fertilize the soil was computed considering that the crop nitrogen requirement would be fully provided by the sediment. Economic feasibility was analysed by comparing the costs of the proposed practice to those obtained if the area was fertilized by traditional means. Results showed that, where reservoirs fall dry frequently and sediments can be removed by excavation, soil fertilization with sediment presents lower costs than those observed for application of commercial chemical fertilizers. Compared to conventional fertilization, when using sediments with high nutrient content, 25% of costs could be saved, while when using sediments with low nutrient content costs are 9% higher. According to the local conditions, sediments with nitrogen content above 1.5 g kg(-1) are cost efficient as nitrogen source. However, physical and chemical analyses are recommended to define the sediment mass to be used and to identify any constraint to the application of the practice, like the high sodium adsorption ratio observed in one of the studied reservoirs, which can contribute to soil salinization. (C) 2019 Elsevier B.V. All rights reserved.
I Can See It in Your Face.
(2019)
The purpose of this study was to illustrate that people’s affective valuation of exercise can be identified in their faces. The study was conducted with a software for automatic facial expression analysis and it involved testing the hypothesis that positive or negative affective valuation occurs spontaneously when people are reminded of exercise. We created a task similar to an emotional Stroop task, in which participants responded to exercise-related and control stimuli with a positive or negative facial expression (smile or frown) depending on whether the photo was presented upright or tilted. We further asked participants how much time they would normally spend for physical exercise, because we assumed that the affective valuation of those who exercise more would be more positive. Based on the data of 86 participants, regression analysis revealed that those who reported less exercise and a more negative reflective evaluation of exercise initiated negative facial expressions on exercise-related stimuli significantly faster than those who reported exercising more often. No significant effect was observed for smile responses. We suspect that responding with a smile to exercise-related stimuli was the congruent response for the majority of our participants, so that for them no Stroop interference occurred in the exercise-related condition. This study suggests that immediate negative affective reactions to exercise-related stimuli result from a postconscious automatic process and can be detected in the study participants’ faces. It furthermore illustrates how methodological paradigms from social–cognition research (here: the emotional Stroop paradigm) can be adapted to collect and analyze biometric data for the investigation of exercisers’ and non-exercisers’ automatic valuations of exercise.
The human intestinal anaerobe Eubacterium ramulus is known for its ability to degrade various dietary flavonoids. In the present study, we demonstrate the cleavage of the heterocyclic C-ring of flavanones and flavanonols by an oxygen-sensitive NADH-dependent reductase, previously described as enoate reductase, from E. ramulus. This flavanone- and flavanonol-cleaving reductase (Fcr) was purified following its heterologous expression in Escherichia coli and further characterized. Fcr cleaved the flavanones naringenin, eriodictyol, liquiritigenin, and homoeriodictyol. Moreover, the flavanonols taxifolin and dihydrokaempferol served as substrates. The catalyzed reactions were stereospecific for the (2R)-enantiomers of the flavanone substrates and for the (25,35)-configured flavanonols. The enantioenrichment of the nonconverted stereoisomers allowed for the determination of hitherto unknown flavanone racemization rates. Fcr formed the corresponding dihydrochalcones and hydroxydihydrochalcones in the course of an unusual reductive cleavage of cyclic ether bonds. Fcr did not convert members of other flavonoid subclasses, including flavones, flavonols, and chalcones, the latter indicating that the reaction does not involve a chalcone intermediate. This view is strongly supported by the observed enantiospecificity of Fcr. Cinnamic acids, which are typical substrates of bacterial enoate reductases, were also not reduced by Fcr. Based on the presence of binding motifs for dinucleotide cofactors and a 4Fe-4S cluster in the amino acid sequence of Fcr, a cofactor-mediated hydride transfer from NADH onto C-2 of the respective substrate is proposed. IMPORTANCE Gut bacteria play a crucial role in the metabolism of dietary flavonoids, thereby contributing to their activation or inactivation after ingestion by the human host. Thus, bacterial activities in the intestine may influence the beneficial health effects of these polyphenolic plant compounds. While an increasing number of flavonoid-converting gut bacterial species have been identified, knowledge of the responsible enzymes is still limited. Here, we characterized Fcr as a key enzyme involved in the conversion of flavonoids of several subclasses by Eubacterium ramulus, a prevalent human gut bacterium. Sequence similarity of this enzyme to hypothetical proteins from other flavonoid-degrading intestinal bacteria in databases suggests a more widespread occurrence of this enzyme. Functional characterization of gene products of human intestinal microbiota enables the assignment of metagenomic sequences to specific bacteria and, more importantly, to certain activities, which is a prerequisite for targeted modulation of gut microbial functionality.
70 Jahre Israel
(2019)
Schon kurz nach dem Zweiten Weltkrieg wurde die These vertreten, die Shoah sei ein wichtiger, wenn nicht gar entscheidender Faktor für die Gründung des Staates Israel gewesen. Der Essay arbeitet heraus, dass der nationalsozialistische Judenmord sicherlich eine moralisch-legitimatorische Funktion gehabt hat, ein unmittelbarer kausaler Zusammenhang mit der Staatsgründung aber nicht nachzuweisen ist.
Katholizismus
(2019)
Detection of Incorporation of p-Coumaric Acid into Photoactive Yellow Protein Variants in Vivo
(2019)
We report the design and characterization of photoactive yellow protein (PYP)-blue fluorescent protein (mTagBFP) fusion constructs that permit the direct assay of reconstitution and function of the PYP domain. These constructs allow for in vivo testing of co-expression systems for enzymatic production of the p-coumaric acid-based PYP chromophore, via the action of tyrosine ammonia lyase and p-coumaroyl-CoA ligase (pCL or 4CL). We find that different 4CL enzymes can function to reconstitute PYP, including 4CL from Arabidopsis thaliana that can produce similar to 100% holo-PYP protein under optimal conditions. mTagBFP fusion constructs additionally enable rapid analysis of effects of mutations on PYP photocycles. We use this mTagBFP fusion strategy to demonstrate in vivo reconstitution of several PYP-based optogenetic tools in Escherichia coli via a biosynthesized chromophore, an important step for the use of these optogenetic tools in vivo in diverse hosts.
Infanticide, the killing of unrelated young, is widespread and frequently driven by sexual conflict. especially in mammals with exclusive maternal care, infanticide by males is common and females suffer fitness costs. Recognizing infanticide risk and adjusting offspring protection accordingly should therefore be adaptive in female mammals. Using a small mammal (Myodes glareolus) in outdoor enclosures, we investigated whether lactating mothers adjust offspring protection, and potential mate search behaviour, in response to different infanticide risk levels. We presented the scent of the litter’s sire or of a stranger male near the female’s nest, and observed female nest presence and movement by radiotracking. While both scents simulated a mating opportunity, they represented lower (sire) and higher (stranger) infanticide risk. compared to the sire treatment, females in the stranger treatment left their nest more often, showed increased activity and stayed closer to the nest, suggesting offspring protection from outside the nest through elevated alertness and vigilance. females with larger litters spent more time investigating scents and used more space in the sire but not in the stranger treatment. Thus, current investment size affected odour inspection and resource acquisition under higher risk. Adjusting nest protection and resource acquisition to infanticide risk could allow mothers to elicit appropriate (fitness-saving) counterstrategies, and thus, may be widespread.