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- quasars: general (8)
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- recombination (8)
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- risk perception (8)
- rotation (8)
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- selection (8)
- site effects (8)
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- tracking (8)
- transition (8)
- trends (8)
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- von Humboldts Hand (8)
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- öffentliche Verwaltung (8)
- Anisotropy (7)
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- Weltbegriff (7)
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- aggregation (7)
- algorithms (7)
- alignment (7)
- allostatic load (7)
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- binaries: eclipsing (7)
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- coherence (7)
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- complexity (7)
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- developmental dyscalculia (7)
- diet (7)
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- digitale Medien (7)
- discrepancy principle (7)
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- disturbance (7)
- duplicate detection (7)
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- ecosystem functioning (7)
- effectiveness (7)
- energy policy (7)
- energy storage (7)
- ensemble Kalman filter (7)
- enzyme (7)
- enzyme catalysis (7)
- ethics (7)
- ethnicity (7)
- exercise therapy (7)
- extinction (7)
- extraction (7)
- extreme rainfall (7)
- fiction (7)
- films (7)
- first passage time (7)
- fiscal policy (7)
- flood (7)
- floodplain (7)
- flow (7)
- fluorescence correlation spectroscopy (7)
- food webs (7)
- function (7)
- functional magnetic resonance imaging (7)
- galaxies (7)
- galaxies: dwarf (7)
- galaxies: starburst (7)
- gene flow (7)
- global warming (7)
- graphene (7)
- gravity (7)
- heart (7)
- heterogeneous catalysis (7)
- home range (7)
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- hydrolysis (7)
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- imaging (7)
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- infrared: stars (7)
- insula (7)
- interoceptive awareness (7)
- isotopes (7)
- jumping (7)
- kardiologische Rehabilitation (7)
- kinematics (7)
- land-use change (7)
- language contact (7)
- last glacial maximum (7)
- lipid metabolism (7)
- low-energy electrons (7)
- magnetism (7)
- meaning (7)
- mechanisms (7)
- media violence (7)
- memory retrieval (7)
- metaanalysis (7)
- metaphor (7)
- microbial ecology (7)
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- minerals (7)
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- music (7)
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- neu gelesen (7)
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- orthography (7)
- oscillations (7)
- pH (7)
- pain (7)
- palaeoecology (7)
- paleoecology (7)
- pandemic (7)
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- parameter estimation (7)
- parliamentary government (7)
- pathogens (7)
- perceptual span (7)
- phonological awareness (7)
- planetary nebulae: general (7)
- planets and satellites: rings (7)
- plant diversity (7)
- plasmonics (7)
- plyometric training (7)
- polyelectrolytes (7)
- porous materials (7)
- predator-prey dynamics (7)
- preview benefit (7)
- production (7)
- pronoun resolution (7)
- propensity score matching (7)
- prosodic boundary cues (7)
- proteasome (7)
- pulsars: general (7)
- quality (7)
- quantification (7)
- reduction (7)
- repair (7)
- retinol (7)
- rheology (7)
- roughness (7)
- screening (7)
- secular trend (7)
- sediment transport (7)
- seismic hazard (7)
- serotonin (7)
- shape-memory effect (7)
- silicon (7)
- size (7)
- soccer (7)
- social inclusion (7)
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- social support (7)
- socioeconomic status (7)
- software engineering (7)
- soil erosion (7)
- solar cells (7)
- solar wind (7)
- sorption (7)
- spelling (7)
- stabile Isotope (7)
- stars: late-type (7)
- sunspots (7)
- surfactants (7)
- tVNS (7)
- taste (7)
- taxonomy (7)
- terrorism (7)
- thermokarst (7)
- thermoresponsiv (7)
- thermoresponsive polymers (7)
- time series (7)
- tomato (7)
- treeline (7)
- trunk (7)
- trust (7)
- ultrasound (7)
- uplift (7)
- urbanization (7)
- vesicles (7)
- wh-in-situ (7)
- working memory capacity (7)
- world literature (7)
- youth sports (7)
- Ästhetik (7)
- Öffentliche Verwaltung (7)
- 3D visualization (6)
- AFM (6)
- Adhäsion (6)
- Ageing (6)
- Agency (6)
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- Algeria (6)
- Alps (6)
- Anisotropy effect (6)
- Antibiotikaresistenz (6)
- Antikörper (6)
- Antwortmengenprogrammierung (6)
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- Aufmerksamkeit (6)
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- Bakterien (6)
- Bayesian data analysis (6)
- Berühren (6)
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- Blockcopolymer (6)
- Briefe (6)
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- Centrosom (6)
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- Click chemistry (6)
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- Copper (6)
- Data assimilation (6)
- Deep learning (6)
- Dielektrophorese (6)
- Digitale Plattformen (6)
- Diskriminierung (6)
- Diskursanalyse (6)
- Dynamic NMR (6)
- Dynamik (6)
- EEG/ERP (6)
- Eastern Europe (6)
- Ellenberg indicator values (6)
- Emotions (6)
- Energy (6)
- Entzündung (6)
- Ethik (6)
- Fachdidaktik Latein (6)
- Fachwissen (6)
- Flood risk (6)
- Fluorescence spectroscopy (6)
- Forschendes Lernen (6)
- Gammastrahlungsastronomie (6)
- Gene-environment interaction (6)
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- Geschmack (6)
- Gesundheit (6)
- H II regions (6)
- HIREC (6)
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- Pyrenees (6)
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- RAFT polymerization (6)
- Raman (6)
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- Reliability (6)
- Rezeption (6)
- Rheology (6)
- Ring current effect (6)
- Romania (6)
- Ruthenium (6)
- SDS-PAGE (6)
- Schadensmodellierung (6)
- School (6)
- Seesedimente (6)
- Selenium (6)
- Self-efficacy (6)
- Semantic Web (6)
- Sensorimotor training (6)
- Sentinel-1 (6)
- Sexual scripts (6)
- Sexual selection (6)
- Sexualität (6)
- Software (6)
- Soil erosion (6)
- Solanum tuberosum (6)
- Speech perception (6)
- Sphingosine 1-phosphate (6)
- Stable isotopes (6)
- Starkregen (6)
- Sternentwicklung (6)
- Steuerung (6)
- Storytelling (6)
- Stretch-shortening cycle (6)
- Subduction zone processes (6)
- Svalbard (6)
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- architecture (6)
- assembly (6)
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- bias (6)
- biodegradable polymers (6)
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- black holes (6)
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- capitalism (6)
- change detection (6)
- chloroplast (6)
- cluster analysis (6)
- co-limitation (6)
- collective memory (6)
- community effect (6)
- competence (6)
- conversation analysis (6)
- copolymers (6)
- corpus study (6)
- costs (6)
- crown compounds (6)
- crystal-structure (6)
- cultural diversity (6)
- cyber victimization (6)
- cyber-physical systems (6)
- cytoskeleton (6)
- databases (6)
- design (6)
- development cooperation (6)
- diabetic nephropathy (6)
- dialogue (6)
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- diffuse radiation (6)
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- dust (6)
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- early warning (6)
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- expertise (6)
- extension (6)
- fNIRS (6)
- fabrication (6)
- facilitation (6)
- federalism (6)
- fertilization (6)
- first passage (6)
- flooding (6)
- fluorescent dyes (6)
- foreland basin (6)
- formal semantics (6)
- galaxies: abundances (6)
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- gamma-rays: general (6)
- gas (6)
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- global (6)
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- heat (6)
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- hydrogen (6)
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- impacts (6)
- implicit (6)
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- knowledge (6)
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- melt inclusions (6)
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- metabolites (6)
- methods: analytical (6)
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- microarray (6)
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- nanoparticle (6)
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- narration (6)
- negation (6)
- network analysis (6)
- neurodegeneration (6)
- neuromuscular control (6)
- nonergodicity (6)
- nucleation (6)
- numerical development (6)
- optimization (6)
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- oxygen (6)
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- respiration (6)
- restoration (6)
- retinol-binding protein 4 (6)
- return to work (6)
- risk assessment (6)
- risk factor (6)
- saccades (6)
- salinity gradient (6)
- scale development (6)
- scattering (6)
- scrambling (6)
- sedaDNA (6)
- self-concept (6)
- self-healing (6)
- sensors (6)
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- social comparison (6)
- sodium (6)
- software (6)
- soil organic carbon (6)
- speed (6)
- standardization (6)
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- stars: magnetic fields (6)
- stimuli-sensitive polymers (6)
- stroke (6)
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- structure elucidation (6)
- sulfite oxidase (6)
- support vector machine (6)
- synchrotron radiation (6)
- systematic literature review (6)
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- teachers (6)
- techniques: image processing (6)
- tendinopathy (6)
- thaliana (6)
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- therapy (6)
- tomography (6)
- tools (6)
- topography (6)
- trade-offs (6)
- training adaptation (6)
- traits (6)
- transcription (6)
- transcriptional memory (6)
- typology (6)
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- uncertainty analysis (6)
- unemployment (6)
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- variation (6)
- vesicle (6)
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- zebrafish (6)
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- Christian Gottfried Ehrenberg (5)
- Classification (5)
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- Community assembly (5)
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- Cultural diversity (5)
- Cyanobakterien (5)
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- DNS (5)
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- Data profiling (5)
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- Digital platforms (5)
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- Holding isometric muscle action (5)
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- cytosine methylation (5)
- definite pseudoclefts (5)
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- duration (5)
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- electropolymerization (5)
- elevated CO2 (5)
- ellipsis processing (5)
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- emulsion (5)
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- energy metabolism (5)
- entity resolution (5)
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- environmental DNA (5)
- equality (5)
- equatorial electrojet (5)
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- event coincidence analysis (5)
- expectation (5)
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- eye-movement control (5)
- ferroelectret (5)
- field (5)
- filaments (5)
- film (5)
- financial markets (5)
- first-passage time (5)
- fish (5)
- flood risk management (5)
- fluctuations (5)
- foraging (5)
- fragmentation (5)
- frailty (5)
- freedom (5)
- fruit (5)
- functionalization (5)
- galaxies: haloes (5)
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- gene regulation (5)
- geometric Brownian motion (5)
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- herbivory (5)
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- heterosis (5)
- heuristics (5)
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- homeostasis (5)
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- hydrological modelling (5)
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- hyporheic zone (5)
- ice-sheet (5)
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- infection (5)
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- integral field spectroscopy (5)
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- interest (5)
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- intersectionality (5)
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- intraspecific trait variation (5)
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- island biogeography (5)
- komplexe Netzwerke (5)
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- mapping (5)
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- maturation (5)
- maturity (5)
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- metabolic network (5)
- metacognition (5)
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- mineralization (5)
- minimum wage (5)
- mitochondrial genome (5)
- mixed methods (5)
- molekulare Motoren (5)
- morphologically complex words (5)
- multiblock copolymer (5)
- multicore architectures (5)
- multiplicative noise (5)
- musicality (5)
- natural hazard (5)
- neovascularization (5)
- neuromuscular (5)
- neutron diffraction (5)
- new public management (5)
- next-generation sequencing (5)
- non-fullerene acceptors (5)
- nonlinear (5)
- nonlinear time series analysis (5)
- norepinephrine (5)
- oncology (5)
- online (5)
- online hate (5)
- ontology (5)
- opposition (5)
- outcome (5)
- oxidation (5)
- paleomagnetism (5)
- palladium (5)
- parental mediation (5)
- partial melting (5)
- participatory research (5)
- particle-in-cell simulations (5)
- pathways (5)
- perceptual reorganization (5)
- periodization (5)
- permafrost degradation (5)
- permeability (5)
- perovskite (5)
- peroxides (5)
- phase separation (5)
- phenomenology (5)
- philosophy (5)
- phonology (5)
- photophysics (5)
- photovoltaics (5)
- physical performance (5)
- physics (5)
- physics education (5)
- planet-star interactions (5)
- plant community (5)
- plant functional trait (5)
- plant functional traits (5)
- plateau (5)
- plyometric exercise (5)
- politeness (5)
- political education (5)
- pollution (5)
- poly(lactic acid) (5)
- polyethylene (5)
- polymer chemistry (5)
- polymer degradation (5)
- polymorphism (5)
- polypeptide (5)
- population genomics (5)
- populations (5)
- pornography (5)
- positive selection (5)
- postural sway (5)
- poverty (5)
- predictability (5)
- preferences (5)
- preferential flow (5)
- pressure (5)
- presupposition (5)
- private households (5)
- probabilistic (5)
- probiotics (5)
- problem solving (5)
- process mining (5)
- production control (5)
- professional knowledge (5)
- professionalization (5)
- prosocial behavior (5)
- protection (5)
- protein modification (5)
- protein-protein interactions (5)
- psychometric properties (5)
- psychotherapy process (5)
- pupillometry (5)
- purification (5)
- qualitative analysis (5)
- quantitative Analyse (5)
- quantitative analysis (5)
- quantum field theory (5)
- race (5)
- racism (5)
- radiocarbon (5)
- random diffusivity (5)
- random-walks (5)
- range shifts (5)
- rare earth elements (5)
- reading comprehension (5)
- real-time rendering (5)
- reconstruction (5)
- record (5)
- reflexives (5)
- regional development (5)
- rejection sensitivity (5)
- relational aggression (5)
- relativistic jets (5)
- repetition (5)
- reproductive success (5)
- research projects (5)
- resonance energy transfer (5)
- resource competition (5)
- rhythmic grouping (5)
- rice (5)
- risk communication (5)
- risk management (5)
- risk-factors (5)
- rotifers (5)
- running (5)
- rural (5)
- salicylic acid (5)
- salt stress (5)
- savanna (5)
- scaling (5)
- scenario (5)
- scenarios (5)
- school shooting (5)
- sedimentary ancient DNA (5)
- seed bank (5)
- seismic noise (5)
- seismicity (5)
- selectivity (5)
- self-employment (5)
- self-evaluation (5)
- semi-arid (5)
- sensitivity analysis (5)
- sentence production (5)
- sentiment analysis (5)
- service-oriented systems engineering (5)
- sex (5)
- shape-memory polymers (5)
- shotgun sequencing (5)
- silica (5)
- single-case experimental design (5)
- single-particle tracking (5)
- smart contracts (5)
- social (5)
- social acceptance (5)
- social networking sites (5)
- software development (5)
- sol-gel (5)
- spatial autocorrelation (5)
- spatial cognition (5)
- spatial-distribution (5)
- species coexistence (5)
- species distribution models (5)
- spectra (5)
- speech motor control (5)
- sphingosine-1-phosphate (5)
- sport-specific performance (5)
- sports (5)
- standards (5)
- starch phosphorylation (5)
- stars: mass loss (5)
- statistical physics (5)
- stellar activity (5)
- stellar evolution (5)
- stochastic differential equations (5)
- stochastic models (5)
- strategic growth adjustments (5)
- strategy (5)
- streamflow (5)
- striking combat sports (5)
- students (5)
- stunting (5)
- sucrose (5)
- sulfate reduction (5)
- supergiants (5)
- superstatistics (5)
- surface processes (5)
- surface relief grating (5)
- surfaces (5)
- surveillance (5)
- survey (5)
- tRNA (5)
- tax reform (5)
- teacher (5)
- tectonic geomorphology (5)
- theory of mind (5)
- thermal modeling (5)
- thermodynamic stability (5)
- thermodynamics (5)
- tiefes Lernen (5)
- top-down control (5)
- tourism (5)
- trajectories (5)
- transcriptome (5)
- trend analysis (5)
- tunneling (5)
- type 2 diabetes mellitus (5)
- tyramine (5)
- ultraviolet: ISM (5)
- uncertainties (5)
- uncertainty quantification (5)
- upconversion (5)
- urban (5)
- validation study (5)
- vegetation change (5)
- victim blame (5)
- virus (5)
- visual culture (5)
- vocational training (5)
- walking (5)
- water resources (5)
- weight (5)
- welfare (5)
- wetland (5)
- wetlands (5)
- words (5)
- workplace (5)
- xanthine dehydrogenase (5)
- öffentlicher Sektor (5)
- ökologische Modellierung (5)
- 1814-1831 (4)
- 2nd-language (4)
- 3D-Visualisierung (4)
- 4 (4)
- ABC transporter (4)
- ARPES (4)
- ASIC (4)
- ATRP (4)
- Academic achievement (4)
- Academic self-concept (4)
- Achilles tendon (4)
- Actin cytoskeleton (4)
- Adipose tissue (4)
- Adolescent (4)
- Aerosol (4)
- Aerosols (4)
- Affordances (4)
- Age of acquisition (4)
- Agrammatism (4)
- Aimé Bonpland (4)
- Akzeptanz (4)
- Alexithymia (4)
- Alignment (4)
- Allometry (4)
- Alter (4)
- Alzheimer (4)
- Amino acids (4)
- Andreas Gryphius (4)
- Anisotropie (4)
- Ankle sprain (4)
- Anthropogene Klimaänderung (4)
- Antiplasmodial (4)
- Arabidopsis-thaliana (4)
- Arbeit (4)
- Arbeitsmarktpolitik (4)
- Arctic lakes (4)
- Aridity (4)
- Arsenic-containing fatty acids (4)
- Astroteilchenphysik (4)
- Atlantic meridional overturning circulation (4)
- Atlantic studies (4)
- Atmosphere (4)
- Attrition (4)
- Augenbewegungen (4)
- Augmented reality (4)
- Ausbreitung (4)
- Auxin (4)
- Averroes (4)
- Azobenzene (4)
- Bakteriophagen (4)
- Bayesian analysis (4)
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- Beratung (4)
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- Body size (4)
- Botanik (4)
- Brachypodium hybridum (4)
- Bragg peak (4)
- Business Process Management (4)
- CCM (4)
- COVID-19 pandemic (4)
- CPS (4)
- Ca2+ (4)
- Calciumphosphat (4)
- Carotenoids (4)
- Catalysis (4)
- Cellulose (4)
- Cenozoic (4)
- Chemotaxis (4)
- Childhood adversity (4)
- Chinese loess (4)
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- Cholesterol (4)
- Chronic back pain (4)
- Chronic conditions (4)
- Climate variability (4)
- Closure Positive Shift (CPS) (4)
- Clustering (4)
- Coexistence (4)
- Collatz (4)
- Communion (4)
- Computational seismology (4)
- Computerlinguistik (4)
- Controlled source seismology (4)
- Correlation (4)
- Coupled oscillators (4)
- Cross-coupling (4)
- Cryo-SEM (4)
- Crystal lattices (4)
- Crystal structure (4)
- Cytochrome P450 (4)
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- DNA Origami (4)
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- DNA strand breaks (4)
- Daniel Kehlmann (4)
- Data Profiling (4)
- Dead Sea Transform (4)
- Debugging (4)
- Dementia (4)
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- Density functional calculations (4)
- Denudation (4)
- Depressive symptoms (4)
- Determinants (4)
- Diagnostik (4)
- Digitale Medien (4)
- Digitale Transformation (4)
- Digitalization (4)
- Dissertation (4)
- Dopamine (4)
- Dormancy (4)
- Drehbuch (4)
- Dual-process (4)
- Duration (4)
- Dynamic pricing (4)
- Dynamical systems (4)
- Dynamics (4)
- Dysphagie (4)
- E-Mail Tracking (4)
- ENSO (4)
- EPR spectroscopy (4)
- Earthquake dynamics (4)
- Earthquake interaction (4)
- Earthquakes (4)
- East African Rift (4)
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- Eastern Cordillera (4)
- Eclogite (4)
- Economics (4)
- Ecuador (4)
- Einkommen (4)
- Eisen (4)
- Electrets (4)
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- Electron transfer (4)
- Elektrokatalyse (4)
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- EnMAP (4)
- Enceladus (4)
- Endothelin (4)
- Energiespeicher (4)
- Englisch (4)
- Enterprise-Resource-Planning (4)
- Enzyme (4)
- Eocene (4)
- Erdmantel (4)
- Erdrutsch (4)
- Europäische Integration (4)
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- Event synchronization (4)
- Event-related potential (4)
- Examen critique (4)
- Exercise therapy (4)
- Expertenbefragung (4)
- Extreme rainfall (4)
- Eye-Tracking (4)
- Eye-movement monitoring (4)
- FLASH (4)
- FTIR spectroscopy (4)
- Fatigue (4)
- Ferroelectrets (4)
- Ferroelektrete (4)
- Fertilization (4)
- Fettsäuren (4)
- Flooding (4)
- Floods (4)
- Flow-Erleben (4)
- Flower buds (4)
- Fluid-rock interaction (4)
- Fokker-Planck equation (4)
- Forecasting (4)
- Foreign Policy (4)
- Forest management (4)
- Forstwirtschaft (4)
- Fourier analysis (4)
- Fragmentierung (4)
- Französisch (4)
- Frauenliteratur (4)
- Fredholm complexes (4)
- Friedrich Wilhelm III. (4)
- Functional diversity (4)
- Fuzzy logic (4)
- Föderalismus (4)
- GC-MS (4)
- GDF15 (4)
- GRACE (4)
- Galaxy: structure (4)
- Gamification (4)
- Gas (4)
- Gaussian processes (4)
- Gelatin (4)
- Genexpression (4)
- Genomik (4)
- Geochronologie (4)
- Geographieunterricht (4)
- Geothermie (4)
- Geowissenschaften (4)
- Geschichte der Poetik (4)
- Geschichtsschreibung (4)
- Gestational diabetes (4)
- Givenness (4)
- Glaciation (4)
- Gleichstellung (4)
- Glucosinolates (4)
- Gondwana (4)
- Graph theory (4)
- Graphtransformationen (4)
- Ground-penetrating radar (4)
- Growth (4)
- Grundwasser (4)
- H.E.S.S. (4)
- HRTEM (4)
- Hermeneutik (4)
- Heterostructures (4)
- Himalaja (4)
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- Hochdruck (4)
- Hochschulen (4)
- Hochschullehre (4)
- Hodge theory (4)
- Home range (4)
- Human (4)
- Human Rights (4)
- Human evolution (4)
- Human impact (4)
- Hydrogele (4)
- Hypoxia (4)
- ICA (4)
- ICSS (4)
- ISM: molecules (4)
- IT-Infrastruktur (4)
- Identity (4)
- Ideologie (4)
- Immobilization (4)
- Implementation (4)
- In-Memory technology (4)
- Income (4)
- India-Asia collision (4)
- Indian Monsoon (4)
- Influenza (4)
- Injury (4)
- Interference (4)
- Internationale Politik (4)
- Interspecific interactions (4)
- Intuitive eating (4)
- IoT (4)
- Ionenmobilitätsspektrometrie (4)
- Ionic liquid (4)
- Irradiation (4)
- Isoflavone (4)
- JUB1 (4)
- Java (4)
- Johann Gottfried Herder (4)
- KMU (4)
- Kalahari (4)
- Kampfsport (4)
- Kardinal Franz Ehrle (4)
- Katalyse (4)
- Kenia (4)
- Kenya Rift (4)
- Kettle holes (4)
- KiK-net (4)
- Kind (4)
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- Knees (4)
- Koexistenz (4)
- Kohlenhydrate (4)
- Kolloid (4)
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- Kompetenzen (4)
- Kompetenzentwicklung (4)
- Korrespondenz (4)
- Kosmopolit (4)
- Kreisgebietsreform (4)
- Kyrgyzstan (4)
- LGM (4)
- Lake (4)
- Landkreise (4)
- Landnutzungsänderung (4)
- Landschaftsentwicklung (4)
- Late Holocene (4)
- Lefschetz number (4)
- Legs (4)
- Lehramtsstudium (4)
- Lehrevaluation (4)
- Lehrkräfte (4)
- Lernmotivation (4)
- Lernstrategien (4)
- Lernumgebung (4)
- Levy walk (4)
- Lexical tone (4)
- Limnology (4)
- Linear mixed model (4)
- Lively Kernel (4)
- Livestock (4)
- Luftverschmutzung (4)
- Lumineszenz (4)
- Lyrik (4)
- MALDI-TOF-MS (4)
- MATLAB (4)
- MCMC (4)
- MRI (4)
- Magnetic properties (4)
- Magnetism (4)
- Magnetotellurics (4)
- Malnutrition (4)
- Martial arts (4)
- Maschinen- und Anlagenbau (4)
- Mathematical model (4)
- Mathematikdidaktik (4)
- Maule earthquake (4)
- Media (4)
- Mediterranean (4)
- Mediterranean Sea (4)
- Membrane (4)
- Metabolisches Syndrom (4)
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- Metaphysik (4)
- Methylmercury (4)
- Microcystis (4)
- Microplastics (4)
- Middle childhood (4)
- Mikrotubuli (4)
- Militärgeschichte (4)
- Mind wandering (4)
- Mixed methods (4)
- Modalität (4)
- Model-Driven Engineering (4)
- Molecular modeling (4)
- Molybdenum (4)
- Mongolei (4)
- Monoclonal antibody (4)
- Monte Carlo method (4)
- Monte-Carlo simulations (4)
- Morphological processing (4)
- Motor control (4)
- Multifunctionality (4)
- Museum (4)
- Mycotoxins (4)
- Mythos (4)
- NEXAFS (4)
- NGS (4)
- NZO (4)
- Nachhaltige Entwicklung (4)
- Naher Osten (4)
- Nanoparticle (4)
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- Nationalsozialismus (4)
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- Neotethys (4)
- Neu-Spanien (4)
- Neue Ökonomische Geographie (4)
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- New-Zealand (4)
- Nitrate (4)
- Nonlinear Dynamics (4)
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- Northern Asia (4)
- Nrf2 (4)
- Number processing (4)
- NutriAct Family Study (4)
- Nährstoffe (4)
- Older patients (4)
- Oman (4)
- Online-Lernen (4)
- Open Source (4)
- Operational momentum (4)
- Organic matter (4)
- Organisation (4)
- Organisationen (4)
- Othering (4)
- Output-Analyse (4)
- Overland flow (4)
- Ozon (4)
- PCR (4)
- PLFA (4)
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- Palestine (4)
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- Palästina (4)
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- Parafoveal processing (4)
- Parsing (4)
- Participation (4)
- Pavlovian-to-instrumental transfer (4)
- Perovskites (4)
- Persistence (4)
- Personalization (4)
- Pesticides (4)
- Pflanzen (4)
- Phase (4)
- Phasenübergang (4)
- Philosophische Anthropologie (4)
- Philosophy (4)
- Phonologie (4)
- Photoelektronenspektroskopie (4)
- Photon Density Wave spectroscopy (4)
- Phylogenetics (4)
- Pinus sylvestris (4)
- Placenta (4)
- Planetary rings (4)
- Plasmodium falciparum (4)
- Political Science (4)
- Politikunterricht (4)
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- Prototyping (4)
- Pseudo-differential operators (4)
- Psychometric properties (4)
- Psychotherapy research (4)
- Quality management (4)
- Qualitätsmanagement (4)
- Quantenpunkte (4)
- Quantitative Trait Locus (4)
- Quantitative Trait Locus analysis (4)
- RAFT-Polymerisation (4)
- Radiation belts (4)
- Random Forests (4)
- Rassendiskriminierung (4)
- Rauschen (4)
- Reachability (4)
- Reading development (4)
- Reading strategies (4)
- Rechtspopulismus (4)
- Recovery (4)
- Recurrence plot (4)
- Refugees (4)
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- Reisetagebücher (4)
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- Röntgenspektroskopie (4)
- Rückenschmerzen (4)
- SDS PAGE (4)
- Saccharomyces cerevisiae (4)
- Salivary gland (4)
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- Scale development (4)
- Schweden (4)
- Schwefel (4)
- Schülermaterial (4)
- Scrum (4)
- Second World War (4)
- Sediment connectivity (4)
- Seismic attenuation (4)
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- Self-control (4)
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- Self-esteem (4)
- Self-paced reading (4)
- Self-regulated learning (4)
- Self-regulation (4)
- Senescence (4)
- Sexual victimization (4)
- Sick leave (4)
- Simulated patients (4)
- Simulationen (4)
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- Speichel (4)
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- Start-Up Subsidies (4)
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- ToF-SIMS (4)
- Toeplitz operators (4)
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- Transdisziplinarität (4)
- Transfer function (4)
- Transkriptom (4)
- Transkriptomik (4)
- Triassic (4)
- Tropical forest (4)
- Tso Moriri Lake (4)
- Turkish-German bilingualism (4)
- Typ-2-Diabetes (4)
- Type 2 diabetes (4)
- Typologie (4)
- Tyramin (4)
- UAV (4)
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- University of Potsdam (4)
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- VIIRS DNB (4)
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- Vertrauen (4)
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- Videoanalyse (4)
- Virtualisierung (4)
- WA-PLS (4)
- Wasserhaushalt (4)
- Weight (4)
- Weight bias internalization (4)
- Weiterbildung (4)
- Wellenleiter (4)
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- Wissenstransfer (4)
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- Work ability (4)
- X-ray emission spectroscopy (4)
- X-ray scattering (4)
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- Xanthomonas (4)
- Zivilgesellschaft (4)
- absorption (4)
- accretion, accretion disks (4)
- accuracy (4)
- achilles tendinopathy (4)
- actin (4)
- action language (4)
- action processing (4)
- action words (4)
- actuation (4)
- adaptive force (4)
- additive particles (4)
- adherence (4)
- adipogenesis (4)
- adjectives (4)
- advanced dynamic flow (4)
- aerosol (4)
- affective (4)
- agency (4)
- agent-based model (4)
- agility (4)
- agreement attraction (4)
- aldehyde oxidase (4)
- allelopathy (4)
- alternatives (4)
- amerikanische Reisetagebücher (4)
- anaphors (4)
- anisotropy (4)
- antifouling (4)
- antilocality (4)
- aphids (4)
- app (4)
- aquatic ecosystems (4)
- aqueous-solution (4)
- arabidopsis (4)
- arabidopsis-thaliana (4)
- argumentation (4)
- arsenolipids present (4)
- association (4)
- astronomy (4)
- astrophysical plasmas (4)
- attachment (4)
- authenticity (4)
- authority (4)
- automatic evaluation (4)
- automatic evaluations (4)
- automation (4)
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- biogenic amine (4)
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- biological age (4)
- biological invasions (4)
- biomarkers (4)
- bis-MGD (4)
- black hole physics (4)
- body image (4)
- body waves (4)
- brushes (4)
- brushite (4)
- buildings (4)
- bulimia nervosa (4)
- bulk heterojunction (4)
- business (4)
- business models (4)
- calcium carbonate (4)
- carbon isotopes (4)
- carbon nitrides (4)
- cartography (4)
- catchments (4)
- categories (4)
- cell cycle (4)
- cell migration (4)
- cell wall (4)
- cellular signalling (4)
- change management (4)
- characteristics (4)
- chronic pain (4)
- circular dichroism (4)
- citizenship (4)
- civil society (4)
- climate adaptation (4)
- climate change impacts (4)
- climate extremes (4)
- climate mitigation (4)
- clinical sample (4)
- clone (4)
- co-occurrence analysis (4)
- coating (4)
- cod-liver (4)
- coefficient (4)
- coercion (4)
- coevolution (4)
- cognitive enhancement (4)
- cognitive modeling (4)
- collaboration (4)
- collaborative consumption (4)
- collagen (4)
- colonization (4)
- color (4)
- combat sports (4)
- common vole (4)
- community structure (4)
- competencies (4)
- compliance (4)
- computer-based training (4)
- conceptualization (4)
- concrete (4)
- conduct problems (4)
- conductivity (4)
- confocal microscopy (4)
- content areas (4)
- content knowledge (4)
- content-addressable memory (4)
- context (4)
- conversational agents (4)
- conversion (4)
- convolutional neural network (4)
- copper(II) (4)
- core (4)
- corpus linguistics (4)
- cosmology (4)
- covariance (4)
- creep (4)
- critical theory (4)
- crop (4)
- crop production (4)
- cross-cultural comparison (4)
- cross-curriculum (4)
- crosslinking (4)
- crust (4)
- cultural identity (4)
- cultural pluralism (4)
- cyberbullying victimization (4)
- cyberhate (4)
- cylindrospermopsin (4)
- cystic fibrosis (4)
- cytochrome c (4)
- data mining (4)
- data preparation (4)
- data quality (4)
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- decarbonization (4)
- definition (4)
- deformation (4)
- degenerative disc disease (4)
- democratic theory (4)
- demography (4)
- deposition (4)
- diachrony (4)
- diagnostic competence (4)
- diagnostics (4)
- dictator game (4)
- dictyostelium (4)
- digital (4)
- digital sovereignty (4)
- digitization (4)
- disability (4)
- discourse production (4)
- diversification (4)
- dog (4)
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- drugs (4)
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- dye (4)
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- dynamic capabilities (4)
- dynamical models (4)
- dynamical systems (4)
- e-government (4)
- eating disorders (4)
- eco-evolutionary experience (4)
- edge effect (4)
- effect (4)
- electron microscopy (4)
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- electron-transfer (4)
- electrostatics (4)
- emissions (4)
- emotional expression (4)
- emotional intelligence (4)
- empowerment (4)
- emulsion polymerization (4)
- endophytes (4)
- endurance exercise (4)
- enhancement (4)
- entanglement (4)
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- errata, addenda (4)
- ethnic differences (4)
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- evaluative study (4)
- evaporites (4)
- event-related brain potentials (4)
- everyday life (4)
- evolutionary history (4)
- exchange (4)
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- expectations (4)
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- family (4)
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- fault (4)
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- feature selection (4)
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- financial crisis (4)
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- finger counting (4)
- firm performance (4)
- first language acquisition (4)
- first-passage (4)
- fiscal federalism (4)
- floral scent (4)
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- fluctuating light (4)
- fluid inclusions (4)
- focal adhesion (4)
- food choice (4)
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- formal verification (4)
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- framework (4)
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- frustration (4)
- functional response (4)
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- galaxies: star formation (4)
- garden-path effect (4)
- gaze-contingent displays (4)
- gene regulatory networks (4)
- genealogy (4)
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- geothermal (4)
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- glutathione (4)
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- government (4)
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- heterostyly (4)
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- hormones (4)
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- hybrid (4)
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- imitation (4)
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- implicit attitude (4)
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- in-service teacher training (4)
- in-situ (4)
- industry 4.0 (4)
- inertial measurement unit (4)
- infinite-dimensional Brownian diffusion (4)
- infrastructure (4)
- inorganic perovskites (4)
- institutional reform (4)
- insulin signaling (4)
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- komplexe Systeme (4)
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- lactate (4)
- land-use intensity (4)
- language change (4)
- large-scale structure of Universe (4)
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- lexical access (4)
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- lichens (4)
- life satisfaction (4)
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- line: identification (4)
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- loading rate (4)
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- locomotion (4)
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- low-back-pain (4)
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- meadow (4)
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- mouse (4)
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- muscle oxygen saturation (4)
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- part 1 (4)
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- receptor (4)
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- relatedness (4)
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- iterative regularization (3)
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- junge Erwachsene (3)
- just transition (3)
- kana (3)
- kanji (3)
- keratinocytes (3)
- kernel density estimation (3)
- kernel methods (3)
- kettle hole (3)
- kinetic instabilities (3)
- knowledge sharing (3)
- kognitive Modellierung (3)
- kollektives Gedächtnis (3)
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- komplexes Netzwerk (3)
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- l-cysteine desulfurase (3)
- labeling (3)
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- land cover change (3)
- land-use (3)
- landscape diversity (3)
- landscape homogenization (3)
- langevin equation (3)
- language attitudes (3)
- language courses (3)
- languages (3)
- large-scale (3)
- large-scale assessment (3)
- last glacial period (3)
- late Holocene (3)
- latitude (3)
- latitudinal gradient (3)
- leaf (3)
- leaf development (3)
- leaf senescence (3)
- leaking (3)
- learning and memory (3)
- learning factories (3)
- learning factory (3)
- learning styles (3)
- lebenslanges Lernen (3)
- lesson evaluation (3)
- lexical development (3)
- lexical tones (3)
- liberalism (3)
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- limits (3)
- line: profiles (3)
- linear programming (3)
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- lipid (3)
- liquid-phase catalysis (3)
- literatures of the world (3)
- liver metabolism (3)
- load (3)
- local (3)
- logarithmic source condition (3)
- lokale Anpassung (3)
- long-distance dispersal (3)
- losses (3)
- lower (3)
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- lupin (3)
- lysosomal storage disorders (3)
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- ländliche Entwicklung (3)
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- magnitude estimation (3)
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- matching (3)
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- method (3)
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This article merges theoretical literature on non-controlling minority shareholdings (NCMS) in a coherent model to study the effects of NCMS on competition and collusion. The model encompasses both the case of a common owner holding shares of rival firms as well as the case of cross ownership among rivals. We find that by softening competition, NCMS weaken the sustainability of collusion under a greater variety of situations than was indicated by earlier literature. Such effects exist, in particular, in the presence of an effective competition authority.
Jurisdiction
(2022)
Individuelle Selbstbestimmung ist Kernelement der Menschenwürde und damit ein Höchstwert der Verfassung. Dennoch scheint sich ihr Schutz auf die Abwesenheit des Staates zu beschränken. Tatsächlich ist sie zahlreichen Gefährdungen ausgesetzt. Der Beitrag will darum ihren Schutz auf das gebotene Niveau heben. Art. 1 Abs. 1 GG verpflichtet den Staat nicht nur zur Achtung, sondern auch zum Schutz der Menschenwürde. Will er diesen Auftrag ernstnehmen, muss er sich entsprechend in den Dienst der Selbstbestimmung seiner Bürger stellen. Dazu darf und muss er ihnen bisweilen Grenzen setzen, um ihre Verantwortungsfähigkeit zu fördern.
Since the beginning of the recent global refugee crisis, researchers have been tackling many of its associated aspects, investigating how we can help to alleviate this crisis, in particular, using ICTs capabilities. In our research, we investigated the use of ICT solutions by refugees to foster the social inclusion process in the host community. To tackle this topic, we conducted thirteen interviews with Syrian refugees in Germany. Our findings reveal different ICT usages by refugees and how these contribute to feeling empowered. Moreover, we show the sources of empowerment for refugees that are gained by ICT use. Finally, we identified the two types of social inclusion benefits that were derived from empowerment sources. Our results provide practical implications to different stakeholders and decision-makers on how ICT usage can empower refugees, which can foster the social inclusion of refugees, and what should be considered to support them in their integration effort.
Since the beginning of the recent global refugee crisis, researchers have been tackling many of its associated aspects, investigating how we can help to alleviate this crisis, in particular, using ICTs capabilities. In our research, we investigated the use of ICT solutions by refugees to foster the social inclusion process in the host community. To tackle this topic, we conducted thirteen interviews with Syrian refugees in Germany. Our findings reveal different ICT usages by refugees and how these contribute to feeling empowered. Moreover, we show the sources of empowerment for refugees that are gained by ICT use. Finally, we identified the two types of social inclusion benefits that were derived from empowerment sources. Our results provide practical implications to different stakeholders and decision-makers on how ICT usage can empower refugees, which can foster the social inclusion of refugees, and what should be considered to support them in their integration effort.
Aging is associated with bone loss, which can lead to osteoporosis and high fracture risk. This coincides with the enhanced formation of bone marrow adipose tissue (BMAT), suggesting a negative effect of bone marrow adipocytes on skeletal health. Increased BMAT formation is also observed in pathologies such as obesity, type 2 diabetes and osteoporosis. However, a subset of bone marrow adipocytes forming the constitutive BMAT (cBMAT), arise early in life in the distal skeleton, contain high levels of unsaturated fatty acids and are thought to provide a physiological function. Regulated BMAT (rBMAT) forms during aging and obesity in proximal regions of the bone and contain a large proportion of saturated fatty acids. Paradoxically, BMAT accumulation is also enhanced during caloric restriction (CR), a life-span extending dietary intervention. This indicates, that different types of BMAT can form in response to opposing nutritional stimuli with potentially different functions.
To this end, two types of nutritional interventions, CR and high fat diet (HFD), that are both described to induce BMAT accumulation were carried out. CR markedly increased BMAT formation in the proximal tibia and led to a higher proportion of unsaturated fatty acids, making it similar to the physiological cBMAT. Additionally, proximal and diaphyseal tibia regions displayed higher adiponectin expression. In aged mice, CR was associated with an improved trabecular bone structure. Taken together, these findings demonstrate, that the type of BMAT that forms during CR might provide beneficial effects for local bone stem/progenitor cells and metabolic health. The HFD intervention performed in this thesis showed no effect on BMAT accumulation and bone microstructure. RNA Seq analysis revealed alterations in the composition of the collagen-containing extracellular matrix (ECM).
In order to investigate the effects of glucose homeostasis on osteogenesis, differentiation capacity of immortalized multipotent mesenchymal stromal cells (MSCs) and osteochondrogenic progenitor cells (OPCs) was analyzed. Insulin improved differentiation in both cell types, however, combination of with a high glucose concentration led to an impaired mineralization of the ECM. In the MSCs, this was accompanied by the formation of adipocytes, indicating negative effects of the adipocytes formed during hyperglycemic conditions on mineralization processes. However, the altered mineralization pattern and structure of the ECM was also observed in OPCs, which did not form any adipocytes, suggesting further negative effects of a hyperglycemic environment on osteogenic differentiation.
In summary, the work provided in this thesis demonstrated that differentiation commitment of bone-resident stem cells can be altered through nutrient availability, specifically glucose. Surprisingly, both high nutrient supply, e.g. the hyperglycemic cell culture conditions, and low nutrient supply, e.g. CR, can induce adipogenic differentiation. However, while CR-induced adipocyte formation was associated with improved trabecular bone structure, adipocyte formation in a hyperglycemic cell-culture environment hampered mineralization. This thesis provides further evidence for the existence of different types of BMAT with specific functions.
Mit dem Klima wandelt sich auch notwendig die offene Gesellschaft. Und mit ihr wandelt sich wiederum auch die Verfassung(-sinterpretation). Periodisch wiederkehrende Gesundheits- und Sicherheitskrisen fordern eine dynamische Reaktion des Grundgesetzes auf mit ihnen einhergehende Probleme. In andauernden Krisen wie der Umweltkrise muss die Verfassung gleichzeitig in vielerlei Hinsicht nachhaltig sein. Dabei muss das, was wir unter Freiheit, Klima‑, Umwelt- oder Tierschutz verstehen, immer im Wandel bleiben.
BACKGROUND: The orbitofrontal cortex (OFC) is implicated in depression. The hypothesis investigated was whether the OFC sensitivity to reward and nonreward is related to the severity of depressive symptoms.
METHODS: Activations in the monetary incentive delay task were measured in the IMAGEN cohort at ages 14 years (n = 1877) and 19 years (n = 1140) with a longitudinal design. Clinically relevant subgroups were compared at ages 19 (high-severity group: n = 116; low-severity group: n = 206) and 14.
RESULTS: The medial OFC exhibited graded activation increases to reward, and the lateral OFC had graded activation increases to nonreward. In this general population, the medial and lateral OFC activations were associated with concurrent depressive symptoms at both ages 14 and 19 years. In a stratified high-severity depressive symptom group versus control group comparison, the lateral OFC showed greater sensitivity for the magnitudes of activations related to nonreward in the high-severity group at age 19 (p = .027), and the medial OFC showed decreased sensitivity to the reward magnitudes in the high-severity group at both ages 14 (p = .002) and 19 (p = .002). In a longitudinal design, there was greater sensitivity to nonreward of the lateral OFC at age 14 for those who exhibited high depressive symptom severity later at age 19 (p = .003).
CONCLUSIONS: Activations in the lateral OFC relate to sensitivity to not winning, were associated with high depressive symptom scores, and at age 14 predicted the depressive symptoms at ages 16 and 19. Activations in the medial OFC were related to sensitivity to winning, and reduced reward sensitivity was associated with concurrent high depressive symptom scores.
BACKGROUND: The orbitofrontal cortex (OFC) is implicated in depression. The hypothesis investigated was whether the OFC sensitivity to reward and nonreward is related to the severity of depressive symptoms.
METHODS: Activations in the monetary incentive delay task were measured in the IMAGEN cohort at ages 14 years (n = 1877) and 19 years (n = 1140) with a longitudinal design. Clinically relevant subgroups were compared at ages 19 (high-severity group: n = 116; low-severity group: n = 206) and 14.
RESULTS: The medial OFC exhibited graded activation increases to reward, and the lateral OFC had graded activation increases to nonreward. In this general population, the medial and lateral OFC activations were associated with concurrent depressive symptoms at both ages 14 and 19 years. In a stratified high-severity depressive symptom group versus control group comparison, the lateral OFC showed greater sensitivity for the magnitudes of activations related to nonreward in the high-severity group at age 19 (p = .027), and the medial OFC showed decreased sensitivity to the reward magnitudes in the high-severity group at both ages 14 (p = .002) and 19 (p = .002). In a longitudinal design, there was greater sensitivity to nonreward of the lateral OFC at age 14 for those who exhibited high depressive symptom severity later at age 19 (p = .003).
CONCLUSIONS: Activations in the lateral OFC relate to sensitivity to not winning, were associated with high depressive symptom scores, and at age 14 predicted the depressive symptoms at ages 16 and 19. Activations in the medial OFC were related to sensitivity to winning, and reduced reward sensitivity was associated with concurrent high depressive symptom scores.
White mica and tourmaline are the dominant hydrothermal alteration minerals at the world-class Panasqueira W-Sn-Cu deposit in Portugal. Thus, understanding the controls on their chemical composition helps to constrain ore formation processes at this deposit and determine their usefulness as pathfinder minerals for mineralization in general. We combine whole-rock geochemistry of altered and unaltered metasedimentary host rocks with in situ LA-ICP-MS measurements of tourmaline and white mica from the alteration halo. Principal component analysis (PCA) is used to better identify geochemical patterns and trends of hydrothermal alteration in the datasets. The hydrothermally altered metasediments are enriched in As, Sn, Cs, Li, W, F, Cu, Rb, Zn, Tl, and Pb relative to unaltered samples. In situ mineral analyses show that most of these elements preferentially partition into white mica over tourmaline (Li, Rb, Cs, Tl, W, and Sn), whereas Zn is enriched in tourmaline. White mica has distinct compositions in different settings within the deposit (greisen, vein selvages, wall rock alteration zone, late fault zone), indicating a compositional evolution with time. In contrast, tourmaline from different settings overlaps in composition, which is ascribed to a stronger dependence on host rock composition and also to the effects of chemical zoning and microinclusions affecting the LA-ICP-MS analyses. Hence, in this deposit, white mica is the better recorder of the fluid composition. The calculated trace-element contents of the Panasqueira mineralizing fluid based on the mica data and estimates of mica-fluid partition coefficients are in good agreement with previous fluid-inclusion analyses. A compilation of mica and tourmaline trace-element compositions from Panasqueira and other W-Sn deposits shows that white mica has good potential as a pathfinder mineral, with characteristically high Li, Cs, Rb, Sn, and W contents. The trace-element contents of hydrothermal tourmaline are more variable. Nevertheless, the compiled data suggest that high Sn and Li contents are distinctive for tourmaline from W-Sn deposits.
In nature, plants are constantly exposed to many transient, but recurring, stresses. Thus, to complete their life cycles, plants require a dynamic balance between capacities to recover following cessation of stress and maintenance of stress memory. Recently, we uncovered a new functional role for macroautophagy/autophagy in regulating recovery from heat stress (HS) and resetting cellular memory of HS inArabidopsis thaliana. Here, we demonstrated that NBR1 (next to BRCA1 gene 1) plays a crucial role as a receptor for selective autophagy during recovery from HS. Immunoblot analysis and confocal microscopy revealed that levels of the NBR1 protein, NBR1-labeled puncta, and NBR1 activity are all higher during the HS recovery phase than before. Co-immunoprecipitation analysis of proteins interacting with NBR1 and comparative proteomic analysis of annbr1-null mutant and wild-type plants identified 58 proteins as potential novel targets of NBR1. Cellular, biochemical and functional genetic studies confirmed that NBR1 interacts with HSP90.1 (heat shock protein 90.1) and ROF1 (rotamase FKBP 1), a member of the FKBP family, and mediates their degradation by autophagy, which represses the response to HS by attenuating the expression ofHSPgenes regulated by the HSFA2 transcription factor. Accordingly, loss-of-function mutation ofNBR1resulted in a stronger HS memory phenotype. Together, our results provide new insights into the mechanistic principles by which autophagy regulates plant response to recurrent HS.
Copolyesterurethanes (PDLCLs) based on oligo(epsilon-caprolactone) (OCL) and oligo(omega-pentadecalactone) (OPDL) segments are biodegradable thermoplastic temperature-memory polymers. The temperature-memory capability in these polymers with crystallizable control units is implemented by a thermomechanical programming process causing alterations in the crystallite arrangement and chain organization. These morphological changes can potentially affect degradation. Initial observations on the macroscopic level inspire the hypothesis that switching of the controlling units causes an accelerated degradation of the material, resulting in programmable degradation by sequential coupling of functions. Hence, detailed degradation studies on Langmuir films of a PDLCL with 40 wt% OPDL content are carried out under enzymatic catalysis. The temperature-memory creation procedure is mimicked by compression at different temperatures. The evolution of the chain organization and mechanical properties during the degradation process is investigated by means of polarization-modulated infrared reflection absorption spectroscopy, interfacial rheology and to some extend by X-ray reflectivity. The experiments on PDLCL Langmuir films imply that degradability is not enhanced by thermal switching, as the former depends on the temperature during cold programming. Nevertheless, the thin film experiments show that the leaching of OCL segments does not induce further crystallization of the OPDL segments, which is beneficial for a controlled and predictable degradation.
Kurzarbeitergeld
(2020)
Das Kurzarbeitergeld (nachfolgend: KuG) ist eines der wichtigsten Instrumente zur Überwindung der aktuellen Corona-Krise. Der Staat übernimmt einen Teil der Lohnkosten und hilft so, gleichzeitig Arbeitsplätze zu erhalten und die Unternehmen zu entlasten. Kurzarbeit ist die vorübergehende Kürzung der betriebsüblichen normalen Arbeitszeit wegen Mangels an Arbeit bei entsprechender Minderung der Entgeltansprüche. Das KuG ersetzt den Teil des Entgelts, der in Folge des Arbeitsausfalls nicht erarbeitet und ausgezahlt werden kann. Ohne KuG läge das Wirtschaftsrisiko beim Arbeitgeber. Könnte er seine Mitarbeiter wegen der Corona-Krise nicht beschäftigen, würde er nach § 615 Satz 1 BGB den vollen Annahmeverzugslohn schulden. Davon entlastet ihn das Instrument der Kurzarbeit. Das KuG deckt die sog. „Nettoentgeltdifferenz“ zwischen dem bisherigen „Soll-Entgelt“ und dem nach Reduzierung von Arbeitszeit verbleibenden „Ist- Entgelt“ in Höhe von 60 % bzw. bei Arbeitnehmern mit Kindern 67 % ab. Schon in der Finanzkrise 2008/2009 hat sich das KuG hervorragend bewährt, damit Unternehmen ihre Belegschaft behalten können, um nach Ende der Krise wieder voll „durchzustarten“.
Symmetry and its breaking crucially define the chemical properties of molecules and their functionality. Resonant inelastic X-ray scattering is a local electronic structure probe reporting on molecular symmetry and its dynamical breaking within the femtosecond scattering duration. Here, we study pyrimidine, a system from the C-2v point group, in an aqueous solution environment, using scattering though its 2a(2) resonance. Despite the absence of clean parity selection rules for decay transitions from in-plane orbitals, scattering channels including decay from the 7b(2) and 11a(1) orbitals with nitrogen lone pair character are a direct probe for molecular symmetry. Computed spectra of explicitly solvated molecules sampled from a molecular dynamics simulation are combined with the results of a quantum dynamical description of the X-ray scattering process. We observe dominant signatures of core-excited Jahn-Teller induced symmetry breaking for resonant excitation. Solvent contributions are separable by shortening of the effective scattering duration through excitation energy detuning.
Analysis of social media using digital methods is a flourishing approach. However, the relatively easy availability of data collected via platform application programming interfaces has arguably led to the predominance of single-platform research of social media. Such research has also privileged the role of text in social media analysis, as a form of data that is more readily gathered and searchable than images. In this paper, we challenge both of these prevailing forms of social media research by outlining a methodology for visual cross-platform analysis (VCPA), defined as the study of still and moving images across two or more social media platforms. Our argument contains three steps. First, we argue that cross-platform analysis addresses a gap in research methods in that it acknowledges the interplay between a social phenomenon under investigation and the medium within which it is being researched, thus illuminating the different affordances and cultures of web platforms. Second, we build on the literature on multimodal communication and platform vernacular to provide a rationale for incorporating the visual into cross-platform analysis. Third, we reflect on an experimental cross-platform analysis of images within social media posts (n = 471,033) used to communicate climate change to advance different modes of macro- and meso-levels of analysis that are natively visual: image-text networks, image plots and composite images. We conclude by assessing the research pathways opened up by VCPA, delineating potential contributions to empirical research and theory and the potential impact on practitioners of social media communication.
While previous research underscores the role of leaders in stimulating employee voice behaviour, comparatively little is known about what affects leaders' support for such constructive but potentially threatening employee behaviours. We introduce leader member exchange quality (LMX) as a central predictor of leaders' support for employees' ideas for constructive change. Apart from a general benefit of high LMX for leaders' idea support, we propose that high LMX is particularly critical to leaders' idea support if the idea voiced by an employee constitutes a power threat to the leader. We investigate leaders' attribution of prosocial and egoistic employee intentions as mediators of these effects. Hypotheses were tested in a quasi-experimental vignette study (N = 160), in which leaders evaluated a simulated employee idea, and a field study (N = 133), in which leaders evaluated an idea that had been voiced to them at work. Results show an indirect effect of LMX on leaders' idea support via attributed prosocial intentions but not via attributed egoistic intentions, and a buffering effect of high LMX on the negative effect of power threat on leaders' idea support. Results differed across studies with regard to the main effect of LMX on idea support.
Although many studies have shown that victims of child abuse have an increased vulnerability to revictimization in intimate relationships, the underlying mechanisms are not yet sufficiently well understood. Therefore, this study aimed at examining this relationship for both sexual and physical forms of violence as well as investigating the potential mediating role of attitudes toward sexual and physical intimate partner violence (IPV). Also, the potential moderating role of gender was explored. Sexual and physical child abuse and IPV victimization in adulthood as well as attitudes toward the respective form of IPV were assessed among 716 participants (448 female) in an online survey. The path analyses showed that child sexual abuse was positively linked to sexual IPV victimization among both women and men, whereas child physical abuse was positively associated with physical IPV victimization among women only. Furthermore, the relationship between both forms of child abuse and IPV victimization was mediated through more supportive attitudes toward the respective forms of IPV, but only among men. This study provides novel insights regarding the links between sexual and physical child abuse and revictimization in adulthood, suggesting that supporting attitudes toward IPV may be seen as vulnerability factor for revictimization. The moderating role of gender is especially discussed.
As research on sexual aggression has been growing, methodological issues in assessing prevalence rates have received increased attention. Building on work by Abbey and colleagues about effects of question format, participants in this study (1,253; 621 female; 632 male) were randomly assigned to one of two versions of the Sexual Aggression and Victimization Scale (SAV-S). In Version 1, the coercive tactic (use/threat of physical force, exploitation of the inability to resist, verbal pressure) was presented first, and sexual acts (sexual touch, attempted and completed sexual intercourse, other sexual acts) were presented as subsequent questions. In Version 2, sexual acts were presented first, and coercive tactics as subsequent questions. No version effects emerged for overall perpetration rates reported by men and women. The overall victimization rate across all items was significantly higher in the tactic-first than in the sexual-act-first conditions for women, but not for men. Classifying participants by their most severe experience of sexual victimization showed that fewer women were in the nonvictim category and more men were in the nonconsensual sexual contact category when the coercive tactic was presented first. Sexual experience background did not moderate the findings. The implications for the measurement of self-reported sexual aggression victimization and perpetration are discussed.
A growing body of research has demonstrated negative effects of sexualization in the media on adolescents' body image, but longitudinal studies and research including interactive and social media are scarce. The current study explored the longitudinal associations of adolescents' use of sexualized video games (SVG) and sexualized Instagram images (SII) with body image concerns. Specifically, our study examined relations between adolescents' SVG and SII use and appearance comparisons, thin- and muscular-ideal internalization, valuing appearance over competence, and body surveillance. A sample of 660 German adolescents (327 female, 333 male;M-age = 15.09 years) participated in two waves with an interval of 6 months. A structural equation model showed that SVG and SII use at Time 1 predicted body surveillance indirectly via valuing appearance over competence at Time 2. Furthermore, SVG and SII use indirectly predicted both thin- and muscular-ideal internalization through appearance comparisons at Time 1. In turn, thin-ideal internalization at Time 1 predicted body surveillance indirectly via valuing appearance over competence at Time 2. The results indicate that sexualization in video games and on Instagram can play an important role in increasing body image concerns among adolescents. We discuss the findings with respect to objectification theory and the predictive value of including appearance comparisons in models explaining the relation between sexualized media and self-objectification.
Magnitude estimation has been studied since the beginnings of scientific psychology and constitutes a fundamental aspect of human behavior. Yet, it has apparently never been noticed that estimates depend on the spatial arrangement used. We tested 167 adults in three experiments to show that the spatial layout of stimuli and responses systematically distorts number estimation, length production, and weight reproduction performance. The direction of distortion depends on the observer's counting habits, but does not seem to reflect the use of spatially associated number concepts. Our results imply that all quantitative estimates are contaminated by a "spell of space" whenever stimuli or responses are spatially distributed.
Alcohol use disorder (AUD) is the most common substance use disorder worldwide. Although dopamine-related findings were often observed in AUD, associated neurobiological mechanisms are still poorly understood. Therefore, in the present study, we investigate D2/3 receptor availability in healthy participants, participants at high risk (HR) to develop addiction (not diagnosed with AUD), and AUD patients in a detoxified stage, applying F-18-fallypride positron emission tomography (F-18-PET). Specifically, D2/3 receptor availability was investigated in (1) 19 low-risk (LR) controls, (2) 19 HR participants, and (3) 20 AUD patients after alcohol detoxification. Quality and severity of addiction were assessed with clinical questionnaires and (neuro)psychological tests. PET data were corrected for age of participants and smoking status. In the dorsal striatum, we observed significant reductions of D2/3 receptor availability in AUD patients compared with LR participants. Further, receptor availability in HR participants was observed to be intermediate between LR and AUD groups (linearly decreasing). Still, in direct comparison, no group difference was observed between LR and HR groups or between HR and AUD groups. Further, the score of the Alcohol Dependence Scale (ADS) was inversely correlated with D2/3 receptor availability in the combined sample. Thus, in line with a dimensional approach, striatal D2/3 receptor availability showed a linear decrease from LR participants to HR participants to AUD patients, which was paralleled by clinical measures. Our study shows that a core neurobiological feature in AUD seems to be detectable in an early, subclinical state, allowing more individualized alcohol prevention programs in the future.
Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis
(2021)
Adaptive plasticity in stress responses is a key element of plant survival strategies. For instance, moderate heat stress (HS) primes a plant to acquire thermotolerance, which allows subsequent survival of more severe HS conditions. Acquired thermotolerance is actively maintained over several days (HS memory) and involves the sustained induction of memory-related genes. Here we show that FORGETTER3/ HEAT SHOCK TRANSCRIPTION FACTOR A3 (FGT3/HSFA3) is specifically required for physiological HS memory and maintaining high memory-gene expression during the days following a HS exposure. HSFA3 mediates HS memory by direct transcriptional activation of memory-related genes after return to normal growth temperatures. HSFA3 binds HSFA2, and in vivo both proteins form heteromeric complexes with additional HSFs. Our results indicate that only complexes containing both HSFA2 and HSFA3 efficiently promote transcriptional memory by positively influencing histone H3 lysine 4 (H3K4) hyper-methylation. In summary, our work defines the major HSF complex controlling transcriptional memory and elucidates the in vivo dynamics of HSF complexes during somatic stress memory. Moderate heat stress primes plants to acquire tolerance to subsequent, more severe heat stress. Here the authors show that the HSFA3 transcription factor forms a heteromeric complex with HSFA2 to sustain activated transcription of genes required for acquired thermotolerance by promoting H3K4 hyper-methylation.
The transversal hypergraph problem asks to enumerate the minimal hitting sets of a hypergraph. If the solutions have bounded size, Eiter and Gottlob [SICOMP'95] gave an algorithm running in output-polynomial time, but whose space requirement also scales with the output. We improve this to polynomial delay and space. Central to our approach is the extension problem, deciding for a set X of vertices whether it is contained in any minimal hitting set. We show that this is one of the first natural problems to be W[3]-complete. We give an algorithm for the extension problem running in time O(m(vertical bar X vertical bar+1) n) and prove a SETH-lower bound showing that this is close to optimal. We apply our enumeration method to the discovery problem of minimal unique column combinations from data profiling. Our empirical evaluation suggests that the algorithm outperforms its worst-case guarantees on hypergraphs stemming from real-world databases.
The Devonian Las Chacras-Potrerillos batholith comprises six nested monzonitic to granitic intrusions with metaluminous to weakly peraluminous composition and a Sr-Nd isotopic signature indicating a dominantly juvenile mantle-derived source. The chemically most evolved units in the southern batholith contain a large number of intra-granitic, pod-shaped tourmaline-bearing pegmatites. This study uses in situ chemical and boron isotopic analyses of tourmaline from nine of these pegmatites to discuss their relationship to the respective host intrusions and the implications of their B-isotope composition for the source and evolution of the magmas. The tourmalines reveal a diversity in element composition (e.g., FeO, MgO, TiO2, CaO, MnO, F) which distinguishes individual pegmatites from one another. However, all have a narrow 5 11 B range of -13.7 to -10.5%0 (n = 100) which indicates a relatively uniform magmatic system and similar temperature conditions during tourmaline crystallization. The average delta(11) B value of -11.7%0 is typical for S-type granites and is within the range reported for peraluminous granites. pegmatites, and metamorphic units of the Ordovician basement into which the Las Chacras-Potrerillos batholith intruded. The B-isotope evidence argues for a crustal boron source like that of the Ordovician basement, in contrast to the metaluminous to weakly peraluminous composition and juvenile initial Sr and Nd isotope ratios of the Las Chacras-Potrerillos batholith magmas. We propose that the boron was not derived from the magma source region but was incorporated from dehydration melting of elastic metasedimentary rocks higher up in the crustal column.
The Altiplano-Puna Plateau holds several shallow lakes, which are very sensitive to climate changes. This work is focused on a high-altitude lake system called Lagunas de Vilama (LVS), located in a complex climatic transition area with scarcity of continuous and homogeneous instrumental records. The objective of this study is to determine the regional spatial-temporal variability of precipitation and evaluate the seasonal and interannual lake responses. We use a lake-surfaces record derived from Landsat images to investigate links with regional precipitations and different climatic forcings. The results reveal that austral summer and autumn precipitations control the variability of the annual lake-surfaces. Also, we found intra-annual and interannual lags in the lake responses to precipitations, and identified several wet and dry stages. Our results show negative trends in precipitations and lake-surfaces, whose were strengthened by a shift to a warm phase of the Atlantic Multidecadal Oscillation in the 1990s. The El Nino Southern Oscillation, Pacific Decadal Oscillation, and Southern Annular Mode also exert a strong influence in the region. This study demonstrates that the variability of LVS lakes is strongly related to the South American Monsoon System dynamics and large-scale climate fordngs from the Pacific and Atlantic Oceans. This work provides novel indices which demonstrated to be good indicators of regional hydroclimatological variability for this region of South America.
The Arnoldi process can be applied to inexpensively approximate matrix functions of the form f (A)v and matrix functionals of the form v*(f (A))*g(A)v, where A is a large square non-Hermitian matrix, v is a vector, and the superscript * denotes transposition and complex conjugation. Here f and g are analytic functions that are defined in suitable regions in the complex plane. This paper reviews available approximation methods and describes new ones that provide higher accuracy for essentially the same computational effort by exploiting available, but generally not used, moment information. Numerical experiments show that in some cases the modifications of the Arnoldi decompositions proposed can improve the accuracy of v*(f (A))*g(A)v about as much as performing an additional step of the Arnoldi process.
Background and aims:
The objective of the present work was to determine to what extent sleep quality may mediate the association between chronodisruption (CD) and metabolic syndrome (MS), and between CD and body composition (BC).
Methodology:
Cross-sectional study which included 300 adult health workers, 150 of whom were night shift workers and thereby exposed to CD. Diagnosis of MS was made based on Adult Treatment Panel III criteria. Sleep quality was measured using the Pittsburgh Sleep Quality Index. Body mass index (BMI), fat mass percentage, and visceral fat percentage were measured as indicators of body composition (BC). Data were analyzed using logistic, linear regression and structural equation models.
Results:
The odds of health workers exposed to CD to suffer MS was 22.13 (IC95 8.68-66.07) when the model was adjusted for age, gender, physical activity and energy consumption. CD was also significantly associated with an increase in fat mass and visceral fat percentages, but not to BMI. Surprisingly, there was not enough evidence supporting the hypothesis that sleep quality contributes to the association between CD and MS or between CD and BC.
Conclusions:
Sleep quality does not mediate the negative effects of CD on MS nor on BC.
Based on suggested interactions of potential tipping elements in the Earth's climate and in ecological systems, tipping cascades as possible dynamics are increasingly discussed and studied. The activation of such tipping cascades would impose a considerable risk for human societies and biosphere integrity. However, there are ambiguities in the description of tipping cascades within the literature so far. Here we illustrate how different patterns of multiple tipping dynamics emerge from a very simple coupling of two previously studied idealized tipping elements. In particular, we distinguish between a two phase cascade, a domino cascade and a joint cascade. A mitigation of an unfolding two phase cascade may be possible and common early warning indicators are sensitive to upcoming critical transitions to a certain degree. In contrast, a domino cascade may hardly be stopped once initiated and critical slowing down-based indicators fail to indicate tipping of the following element. These different potentials for intervention and anticipation across the distinct patterns of multiple tipping dynamics should be seen as a call to be more precise in future analyses of cascading dynamics arising from tipping element interactions in the Earth system.
The synthesis and the crystal structure of the double cluster compound [Nb6Cl14(MeCN)(4)][Nb6Cl14(pyz)(4)]middot6CH(3)CN are described. The synthesis is based on a partial ligand exchange reaction, which proceeds upon dissolving [Nb6Cl14(pyz)(4)]middot2CH(2)Cl(2) in acetonitrile. The compound is built up of two discrete neutral cluster units, which consist of octahedra of Nb-6 atoms coordinated by 12 edge-bridging chlorido and two terminal chlorido ligands, and four acetonitrile ligands on one and four pyrazine ligands on the other cluster unit. Co-crystallized acetonitrile molecules are also present. The single-crystal structure determination has revealed a cluster arrangement in which the [Nb6Cl14(pyz)(4)] units are connected by (halogen) lone-pair-(pyrazine) pi interactions. These lead to chains of [Nb6Cl14(pyz)(4)] clusters. These chains are further connected to cluster layers by (nitrile-halogen) dipole-dipole interactions, in which the [Nb6Cl14(MeCN)(4)] and co-crystallized MeCN molecules are also involved. These cluster layers are arranged parallel to the crystallographic {011} plane.
Purpose UK guidelines recommend dietary saturated fatty acids (SFAs) should not exceed 10% total energy (%TE) for cardiovascular disease prevention, with benefits observed when SFAs are replaced with unsaturated fatty acids (UFAs). This study aimed to assess the efficacy of a dietary exchange model using commercially available foods to replace SFAs with UFAs. Methods Healthy men (n = 109, age 48, SD 11 year) recruited to the Reading, Imperial, Surrey, Saturated fat Cholesterol Intervention-1 (RISSCI-1) study (ClinicalTrials.Gov n degrees NCT03270527) followed two sequential 4-week isoenergetic moderate-fat (34%TE) diets: high-SFA (18%TE SFAs, 16%TE UFAs) and low-SFA (10%TE SFAs, 24%TE UFAs). Dietary intakes were assessed using 4-day weighed diet diaries. Nutrient intakes were analysed using paired t-tests, fasting plasma phospholipid fatty acid (PL-FA) profiles and dietary patterns were analysed using orthogonal partial least square discriminant analyses. Results Participants exchanged 10.2%TE (SD 4.1) SFAs for 9.7%TE (SD 3.9) UFAs between the high and low-SFA diets, reaching target intakes with minimal effect on other nutrients or energy intakes. Analyses of dietary patterns confirmed successful incorporation of recommended foods from commercially available sources (e.g. dairy products, snacks, oils, and fats), without affecting participants' overall dietary intakes. Analyses of plasma PL-FAs indicated good compliance to the dietary intervention and foods of varying SFA content. Conclusions RISSCI-1 dietary exchange model successfully replaced dietary SFAs with UFAs in free-living healthy men using commercially available foods, and without altering their dietary patterns. Further intervention studies are required to confirm utility and feasibility of such food-based dietary fat replacement models at a population level.
This paper studies cosmic-ray (CR) transport in magnetohydrodynamic (MHD) turbulence. CR transport is strongly dependent on the properties of the magnetic turbulence.
We perform test particle simulations to study the interactions of CR with both total MHD turbulence and decomposed MHD modes.
The spatial diffusion coefficients and the pitch angle scattering diffusion coefficients are calculated from the test particle trajectories in turbulence.
Our results confirm that the fast modes dominate the CR propagation, whereas Alfven and slow modes are much less efficient and have shown similar pitch-angle scattering rates.
We investigate the cross field transport on large and small scales. On large/global scales, normal diffusion is observed and the diffusion coefficient is suppressed by M-A(zeta) compared to the parallel diffusion coefficients, with zeta closer to 4 in Alfven modes than that in total turbulence, as theoretically expected.
For the CR transport on scales smaller than the turbulence injection scale, both the local and global magnetic reference frames are adopted. Superdiffusion is observed on such small scales in all the cases. Particularly, CR transport in Alfven modes show clear Richardson diffusion in the local reference frame. The diffusion transitions smoothly from the Richardson's one with index 1.5 to normal diffusion as the particle mean free path decreases from lambda(parallel to) >> L to lambda(parallel to) << L, where L is the injection/coherence length of turbulence.
Our results have broad applications to CRs in various astrophysical environments.
Active matter broadly covers the dynamics of self-propelled particles.
While the onset of collective behavior in homogenous active systems is relatively well understood, the effect of inhomogeneities such as obstacles and traps lacks overall clarity.
Here, we study how interacting, self-propelled particles become trapped and released from a trap.
We have found that captured particles aggregate into an orbiting condensate with a crystalline structure. As more particles are added, the trapped condensates escape as a whole.
Our results shed light on the effects of confinement and quenched disorder in active matter.
„Zur rechten Zeit“ ist ein flüssig geschriebenes, gut lesbares und an ein breites Publikum gerichtetes Sachbuch. Es will die Geschichte der Bundesrepublik „unter dem Eindruck der gegenwärtigen rechten Konjunktur anders denn als gängige Erfolgsgeschichte“ (S. 10) erzählen. Die Autorinnen und Autoren sind nicht bestrebt, das Erfolgsnarrativ radikal zu dekonstruieren und damit den Forschungsertrag der Zeitgeschichtsschreibung zu ignorieren, wohl aber rekonstruieren sie Abschattungen und Brüche, die zeigen, dass der Prozess weniger geradlinig war als häufig angenommen – und dass seine Ergebnisse nicht irreversibel sind.
Quantification of reaction fluxes of metabolic networks can help us understand how the integration of different metabolic pathways determines cellular functions. Yet, intracellular fluxes cannot be measured directly but are estimated with metabolic flux analysis (MFA), which relies on the patterns of isotope labeling of metabolites in the network. The application of MFA also requires a stoichiometric model with atom mappings that are currently not available for the majority of large-scale metabolic network models, particularly of plants. While automated approaches such as the Reaction Decoder Toolkit (RDT) can produce atom mappings for individual reactions, tracing the flow of individual atoms of the entire reactions across a metabolic model remains challenging. Here we establish an automated workflow to obtain reliable atom mappings for large-scale metabolic models by refining the outcome of RDT, and apply the workflow to metabolic models of Arabidopsis thaliana. We demonstrate the accuracy of RDT through a comparative analysis with atom mappings from a large database of biochemical reactions, MetaCyc. We further show the utility of our automated workflow by simulating N-15 isotope enrichment and identifying nitrogen (N)-containing metabolites which show enrichment patterns that are informative for flux estimation in future N-15-MFA studies of A. thaliana. The automated workflow established in this study can be readily expanded to other species for which metabolic models have been established and the resulting atom mappings will facilitate MFA and graph-theoretic structural analyses with large-scale metabolic networks.
Tacitus' Wonders
(2022)
This volume approaches the broad topic of wonder in the works of Tacitus, encompassing paradox, the marvellous and the admirable. Recent scholarship on these themes in Roman literature has tended to focus on poetic genres, with comparatively little attention paid to historiography: Tacitus, whose own judgments on what is worthy of note have often differed in interesting ways from the preoccupations of his readers, is a fascinating focal point for this complementary perspective.
Scholarship on Tacitus has to date remained largely marked by a divide between the search for veracity – as validated by modern historiographical standards – and literary approaches, and as a result wonders have either been ignored as unfit for an account of history or have been deprived of their force by being interpreted as valid only within the text. While the modern ideal of historiographical objectivity tends to result in striving for consistent heuristic and methodological frameworks, works as varied as Tacitus' Histories, Annals and opera minora can hardly be prefaced with a statement of methodology broad enough to escape misrepresenting their diversity. In our age of specialization a streamlined methodological framework is a virtue, but it should not be assumed that Tacitus had similar priorities, and indeed the Histories and Annals deserve to be approached with openness towards the variety of perspectives that a tradition as rich as Latin historiographical prose can include within its scope. This collection proposes ways to reconcile the divide between history and historiography by exploring contestable moments in the text that challenge readers to judge and interpret for themselves, with individual chapters drawing on a range of interpretive approaches that mirror the wealth of authorial and reader-specific responses in play.
Long- and short-term monitoring of a dam in response to seasonal changes and ground motion loading
(2021)
An experimental multi-parameter structural monitoring system has been installed on the Kurpsai dam, western Kyrgyz Republic. This system consists of equipment for seismic and strain measurements for making longer- (days, weeks, months) and shorter- (minutes, hours) term observations, dealing with, for example seasonal (longer) effects or the response of the dam to ground motion from noise or seismic events. Fibre-optic strain sensors allow the seasonal and daily opening and closing of the spaces between the dam's segments to be tracked. For the seismic data, both amplitude (in terms of using differences in amplitudes in the Fourier spectra for mapping the modes of vibration of the dam) and their time-frequency distribution for a set of small to moderate seismic events are investigated and the corresponding phase variabilities (in terms of lagged coherency) are evaluated. Even for moderate levels of seismic-induced ground motion, some influence on the structural response can be detected, which then sees the dam quickly return to its original state. A seasonal component was identified in the strain measurements, while levels of noise arising from the operation of the dam's generators and associated water flow have been provisionally identified.
Lost in Germania
(2021)
Tacitus’ Germania is notable for its absences: lacking a preface and programmatic statements, and being the only ethnographic monograph to have survived from Greco-Roman antiquity, readers have often leapt to fill in its perceived blanks. This chapter aims at redressing the effects of overdetermined readings by interpreting the text’s absences as significant in their own right.
Centroid moment tensor (CMT) parameters can be estimated from seismic waveforms. Since these data indirectly observe the deformation process, CMTs are inferred as solutions to inverse problems which are generally underdetermined and require significant assumptions, including assumptions about data noise. Broadly speaking, we consider noise to include both theory and measurement errors, where theory errors are due to assumptions in the inverse problem and measurement errors are caused by the measurement process. While data errors are routinely included in parameter estimation for full CMTs, less attention has been paid to theory errors related to velocity-model uncertainties and how these affect the resulting moment-tensor (MT) uncertainties. Therefore, rigorous uncertainty quantification for CMTs may require theory-error estimation which becomes a problem of specifying noise models. Various noise models have been proposed, and these rely on several assumptions. All approaches quantify theory errors by estimating the covariance matrix of data residuals. However, this estimation can be based on explicit modelling, empirical estimation and/or ignore or include covariances. We quantitatively compare several approaches by presenting parameter and uncertainty estimates in nonlinear full CMT estimation for several simulated data sets and regional field data of the M-1 4.4, 2015 June 13 Fox Creek, Canada, event. While our main focus is at regional distances, the tested approaches are general and implemented for arbitrary source model choice. These include known or unknown centroid locations, full MTs, deviatoric MTs and double-couple MTs. We demonstrate that velocity-model uncertainties can profoundly affect parameter estimation and that their inclusion leads to more realistic parameter uncertainty quantification. However, not all approaches perform equally well. Including theory errors by estimating non-stationary (non-Toeplitz) error covariance matrices via iterative schemes during Monte Carlo sampling performs best and is computationally most efficient. In general, including velocity-model uncertainties is most important in cases where velocity structure is poorly known.
Successful conservation efforts have led to recent increases of large mammals such as European bison Bison bonasus, moose Alces alces and grey wolf Canis lupus and their return to former habitats in central Europe.
While embraced by some, the recovery of these species is a controversial topic and holds potential for human-wildlife conflicts.
Involving the public has been suggested to be an effective method for monitoring wildlife and mitigating associated conflicts.
To assess two interrelated prerequisites for engaging people in Citizen Science (CS)-knowledge of returning species and respondents' readiness to participate in CS activities for monitoring and managing these species-we conducted a survey (questionnaire) in two wildlife parks located in different states of Germany.
Based on 472 complete questionnaires, we developed generalized linear models to understand how sociodemographic variables and exposure to the species affected visitors' knowledge of each species, and to investigate if sociodemographic variables and knowledge influenced the likelihood of visitors to participate in CS activities.
Almost all visitors were aware of the returning wolf population, while knowledge and awareness about bison and moose were significantly lower.
Knowledge of the two herbivores differed geographically (higher knowledge of moose in the north-eastern state), possibly indicating a positive association between exposure to the species and knowledge.
However, models generally performed poorly in predicting knowledge about wildlife, suggesting that such specific knowledge is insufficiently explained by sociodemographic variables. Our model, which explained stated willingness in CS indicated that younger participants and those with higher knowledge scores in the survey were more willing to engage in CS activities.
Overall, our analyses highlight how exposure to large mammals, knowledge about wildlife and human demographics are interrelated-insights that are helpful for effectively recruiting citizen scientists for wildlife conservation.
Read the free Plain Language Summary for this article on the Journal blog.
This study investigates the use of pulse stretching (skew-sized) inverters for monitoring the variation of count rate and linear energy transfer (LET) of energetic particles. The basic particle detector is a cascade of two pulse stretching inverters, and the required sensing area is obtained by connecting up to 12 two-inverter cells in parallel and employing the required number of parallel arrays. The incident particles are detected as single-event transients (SETs), whereby the SET count rate denotes the particle count rate, while the SET pulsewidth distribution depicts the LET variations. The advantage of the proposed solution is the possibility to sense the LET variations using fully digital processing logic. SPICE simulations conducted on IHP's 130-nm CMOS technology have shown that the SET pulsewidth varies by approximately 550 ps over the LET range from 1 to 100 MeV center dot cm(2) center dot mg(-1). The proposed detector is intended for triggering the fault-tolerant mechanisms within a self-adaptive multiprocessing system employed in space. It can be implemented as a standalone detector or integrated in the same chip with the target system.
Fatty acids are widely used to study trophic interactions in food web assemblages. Generally, it is assumed that there is a very small modification of fatty acids from one trophic step to another, making them suitable as trophic biomarkers. However, recent literature provides evidence that many fishes possess genes encoding enzymes with a role in bioconversion, thus the capability for bioconversion might be more widespread than previously assumed. Nonetheless, empirical evidence for biosynthesis occurring in natural populations remains scarce. In this study, we investigated different feeding types of perch (Perca fluviatilis) that are specialized on specific resources with different levels of highly unsaturated fatty acids (HUFAs), and analyzed the change between HUFA proportions in perch muscle tissue compared to their resources. Perch showed matching levels to their resources for EPA, but ARA and especially DHA were accumulated. Compound-specific stable isotope analyses helped us to identify the origin of HUFA carbon. Our results suggest that perch obtain a substantial amount of DHA via bioconversion when feeding on DHA-poor benthic resources. Thus, our data indicate the capability of bioconversion of HUFAs in a natural freshwater fish population.
Circular economy
(2021)
In a circular economy, the use of recycled resources in production is a key performance indicator for management. Yet, academic studies are still unable to inform managers on appropriate recycling and pricing policies. We develop an optimal control model integrating a firm's recycling rate, which can use both virgin and recycled resources in the production process. Our model accounts for recycling influence both at the supply- and demandsides. The positive effect of a firm's use of recycled resources diminishes over time but may increase through investments. Using general formulations for demand and cost, we analytically examine joint dynamic pricing and recycling investment policies in order to determine their optimal interplay over time. We provide numerical experiments to assess the existence of a steady-state and to calculate sensitivity analyses with respect to various model parameters. The analysis shows how to dynamically adapt jointly optimized controls to reach sustainability in the production process. Our results pave the way to sounder sustainable practices for firms operating within a circular economy.
Cirrus is the only cloud type capable of inducing daytime cooling or heating at the top of the atmosphere (TOA) and the sign of its radiative effect highly depends on its optical depth. However, the investigation of its geometrical and optical properties over the Arctic is limited. In this work the long-term properties of cirrus clouds are explored for the first time over an Arctic site (Ny-Alesund, Svalbard) using lidar and radiosonde measurements from 2011 to 2020. The optical properties were quality assured, taking into account the effects of specular reflections and multiple-scattering. Cirrus clouds were generally associated with colder and calmer wind conditions compared to the 2011-2020 climatology. However, the dependence of cirrus properties on temperature and wind speed was not strong. Even though the seasonal cycle was not pronounced, the winter-time cirrus appeared under lower temperatures and stronger wind conditions. Moreover, in winter, geometrically- and optically-thicker cirrus were found and their ice particles tended to be more spherical. The majority of cirrus was associated with westerly flow and westerly cirrus tended to be geometrically-thicker. Overall, optically-thinner layers tended to comprise smaller and less spherical ice crystals, most likely due to reduced water vapor deposition on the particle surface. Compared to lower latitudes, the cirrus layers over Ny-Alesund were more absorbing in the visible spectral region and they consisted of more spherical ice particles.
MALDI-TOF-MS-based identification of monoclonal murine Anti-SARS-CoV-2 antibodies within one hour
(2022)
During the SARS-CoV-2 pandemic, many virus-binding monoclonal antibodies have been developed for clinical and diagnostic purposes. This underlines the importance of antibodies as universal bioanalytical reagents. However, little attention is given to the reproducibility crisis that scientific studies are still facing to date. In a recent study, not even half of all research antibodies mentioned in publications could be identified at all. This should spark more efforts in the search for practical solutions for the traceability of antibodies. For this purpose, we used 35 monoclonal antibodies against SARS-CoV-2 to demonstrate how sequence-independent antibody identification can be achieved by simple means applied to the protein. First, we examined the intact and light chain masses of the antibodies relative to the reference material NIST-mAb 8671. Already half of the antibodies could be identified based solely on these two parameters. In addition, we developed two complementary peptide mass fingerprinting methods with MALDI-TOF-MS that can be performed in 60 min and had a combined sequence coverage of over 80%. One method is based on the partial acidic hydrolysis of the protein by 5 mM of sulfuric acid at 99 degrees C. Furthermore, we established a fast way for a tryptic digest without an alkylation step. We were able to show that the distinction of clones is possible simply by a brief visual comparison of the mass spectra. In this work, two clones originating from the same immunization gave the same fingerprints. Later, a hybridoma sequencing confirmed the sequence identity of these sister clones. In order to automate the spectral comparison for larger libraries of antibodies, we developed the online software ABID 2.0. This open-source software determines the number of matching peptides in the fingerprint spectra. We propose that publications and other documents critically relying on monoclonal antibodies with unknown amino acid sequences should include at least one antibody fingerprint. By fingerprinting an antibody in question, its identity can be confirmed by comparison with a library spectrum at any time and context.
Both climate change and land use regimes affect the viability of populations, but they are often studied separately. Moreover, population viability analyses (PVAs) often ignore the effects of large environmental gradients and use temporal resolutions that are too coarse to take into account that different stages of a population's life cycle may be affected differently by climate change. Here, we present the High-resolution Large Environmental Gradient (HiLEG) model and apply it in a PVA with daily resolution based on daily climate projections for Northwest Germany. We used the large marsh grasshopper (LMG) as the target species and investigated (1) the effects of climate change on the viability and spatial distribution of the species, (2) the influence of the timing of grassland mowing on the species and (3) the interaction between the effects of climate change and grassland mowing. The stageand cohort-based model was run for the spatially differentiated environmental conditions temperature and soil moisture across the whole study region. We implemented three climate change scenarios and analyzed the population dynamics for four consecutive 20-year periods. Climate change alone would lead to an expansion of the regions suitable for the LMG, as warming accelerates development and due to reduced drought stress. However, in combination with land use, the timing of mowing was crucial, as this disturbance causes a high mortality rate in the aboveground life stages. Assuming the same date of mowing throughout the region, the impact on viability varied greatly between regions due to the different climate conditions. The regional negative effects of the mowing date can be divided into five phases: (1) In early spring, the populations were largely unaffected in all the regions; (2) between late spring and early summer, they were severely affected only in warm regions; (3) in summer, all the populations were severely affected so that they could hardly survive; (4) between late summer and early autumn, they were severely affected in cold regions; and (5) in autumn, the populations were equally affected across all regions. The duration and start of each phase differed slightly depending on the climate change scenario and simulation period, but overall, they showed the same pattern. Our model can be used to identify regions of concern and devise management recommendations. The model can be adapted to the life cycle of different target species, climate projections and disturbance regimes. We show with our adaption of the HiLEG model that high-resolution PVAs and applications on large environmental gradients can be reconciled to develop conservation strategies capable of dealing with multiple stressors.
Supergenes are nonrecombining genomic regions ensuring the coinheritance of multiple, coadapted genes. Despite the importance of supergenes in adaptation, little is known on how they originate. A classic example of supergene is the S locus controlling heterostyly, a floral heteromorphism occurring in 28 angiosperm families. In Primula, heterostyly is characterized by the cooccurrence of two complementary, self-incompatible floral morphs and is controlled by five genes clustered in the hemizygous, ca. 300-kb S locus. Here, we present the first chromosome-scale genome assembly of any heterostylous species, that of Primula veris (cowslip). By leveraging the high contiguity of the P. veris assembly and comparative genomic analyses, we demonstrated that the S-locus evolved via multiple, asynchronous gene duplications and independent gene translocations. Furthermore, we discovered a new whole-genome duplication in Ericales that is specific to the Primula lineage. We also propose a mechanism for the origin of S-locus hemizygosity via nonhomologous recombination involving the newly discovered two pairs of CFB genes flanking the S locus. Finally, we detected only weak signatures of degeneration in the S locus, as predicted for hemizygous supergenes. The present study provides a useful resource for future research addressing key questions on the evolution of supergenes in general and the S locus in particular: How do supergenes arise? What is the role of genome architecture in the evolution of complex adaptations? Is the molecular architecture of heterostyly supergenes across angiosperms similar to that of Primula?
N-of-1 trials are the gold standard study design to evaluate individual treatment effects and derive personalized treatment strategies. Digital tools have the potential to initiate a new era of N-of-1 trials in terms of scale and scope, but fully functional platforms are not yet available.
Here, we present the open source StudyU platform, which includes the StudyU Designer and StudyU app.
With the StudyU Designer, scientists are given a collaborative web application to digitally specify, publish, and conduct N-of-1 trials.
The StudyU app is a smartphone app with innovative user-centric elements for participants to partake in trials published through the StudyU Designer to assess the effects of different interventions on their health.
Thereby, the StudyU platform allows clinicians and researchers worldwide to easily design and conduct digital N-of-1 trials in a safe manner.
We envision that StudyU can change the landscape of personalized treatments both for patients and healthy individuals, democratize and personalize evidence generation for self-optimization and medicine, and can be integrated in clinical practice.
Ancient genome provides insights into the history of Eurasian lynx in Iberia and Western Europe
(2022)
The Eurasian lynx (Lynx lynx) is one of the most widely distributed felids in the world. However, most of its populations started to decline a few millennia ago. Historical declines have been especially severe in Europe, and particularly in Western Europe, from where the species disappeared in the last few centuries. Here, we analyze the genome of an Eurasian lynx inhabiting the Iberian Peninsula 2500 ya, to gain insights into the phylogeographic position and genetic status of this extinct population. Also, we contextualize previous ancient data in the light of new phylogeographic studies of the species. Our results suggest that the Iberian population is part of an extinct European lineage closely related to the current Carpathian-Baltic lineages. Also, this sample holds the lowest diversity reported for the species so far, and similar to that of the highly endangered Iberian lynx. A combination of historical factors, such as a founder effect while colonizing the peninsula, together with intensified human impacts during the Holocene in the Cantabrian strip, could have led to a genetic impoverishment of the population and precipitated its extinction. Mitogenomic lineages distribution in space and time support the long-term coexistence of several lineages of Eurasian lynx in Western Europe with fluctuating ranges. While mitochondrial sequences related to the lineages currently found in Balkans and Caucasus were predominant during the Pleistocene, those more closely related to the lineage currently distributed in Central Europe prevailed during the Holocene. The use of ancient genomics has proven to be a useful tool to understand the biogeographic pattern of the Eurasian lynx in the past.
The water vapor-induced swelling, as well as subsequent phase-transition kinetics, of thin films of a diblock copolymer (DBC) loaded with different amounts of the salt NaBr, is investigated in situ. In dilute aqueous solution, the DBC features an orthogonally thermoresponsive behavior. It consists of a zwitterionic poly(sulfobetaine) block, namely, poly(4-(N-(3'-methacrylamidopropyl)-N, N-dimethylammonio) butane-1-sulfonate) (PSBP), showing an upper critical solution temperature, and a nonionic block, namely, poly(N-isopropylmethacrylamide) (PNIPMAM), exhibiting a lower critical solution temperature. The swelling kinetics in D2O vapor at 15 degrees C and the phase transition kinetics upon heating the swollen film to 60 degrees C and cooling back to 15 degrees C are followed with simultaneous time-of-flight neutron reflectometry and spectral reflectance measurements. These are complemented by Fourier transform infrared spectroscopy. The collapse temperature of PNIPMAM and the swelling temperature of PSBP are found at lower temperatures than in aqueous solution, which is attributed to the high polymer concentration in the thin-film geometry. Upon inclusion of sub-stoichiometric amounts (relative to the monomer units) of NaBr in the films, the water incorporation is significantly increased. This increase is mainly attributed to a salting-in effect on the zwitterionic PSBP block. Whereas the addition of NaBr notably shifts the swelling temperature of PSBP to lower temperatures, the collapse temperature of PNIPMAM remains unaffected by the presence of salt in the films.
Complex networks are abundant in nature and many share an important structural property: they contain a few nodes that are abnormally highly connected (hubs). Some of these hubs are called influencers because they couple strongly to the network and play fundamental dynamical and structural roles. Strikingly, despite the abundance of networks with influencers, little is known about their response to stochastic forcing. Here, for oscillatory dynamics on influencer networks, we show that subjecting influencers to an optimal intensity of noise can result in enhanced network synchronization. This new network dynamical effect, which we call coherence resonance in influencer networks, emerges from a synergy between network structure and stochasticity and is highly nonlinear, vanishing when the noise is too weak or too strong. Our results reveal that the influencer backbone can sharply increase the dynamical response in complex systems of coupled oscillators. Influencer networks include a small set of highly-connected nodes and can reach synchrony only via strong node interaction. Tonjes et al. show that introducing an optimal amount of noise enhances synchronization of such networks, which may be relevant for neuroscience or opinion dynamics applications.