Sabrina Schmidt, Daniela Reil, Kathrin Jeske, Stephan Drewes, Ulrike Rosenfeld, Stefan Fischer, Nastasja G. Spierling, Anton Labutin, Gerald Heckel, Jens Jacob, Rainer G. Ulrich, Christian Imholt
- Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (Microtus arvalis), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host-pathogen complex presents an ideal system to study the complex mechanisms of pathogen transmission in a wild rodent reservoir. We investigated the dynamics of TULV prevalence and the subsequent potential effects on the molecular evolution of TULV in common voles of the Central evolutionary lineage. Rodents were trapped for three years in four regions of Germany and samples were analyzed for the presence of TULV-reactive antibodies and TULV RNA with subsequent sequence determination. The results show that individual (sex) and population-level factors (abundance) of hosts were significant predictors of local TULV dynamics. At the large geographic scale, different phylogenetic TULV clades and an overallTula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (Microtus arvalis), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host-pathogen complex presents an ideal system to study the complex mechanisms of pathogen transmission in a wild rodent reservoir. We investigated the dynamics of TULV prevalence and the subsequent potential effects on the molecular evolution of TULV in common voles of the Central evolutionary lineage. Rodents were trapped for three years in four regions of Germany and samples were analyzed for the presence of TULV-reactive antibodies and TULV RNA with subsequent sequence determination. The results show that individual (sex) and population-level factors (abundance) of hosts were significant predictors of local TULV dynamics. At the large geographic scale, different phylogenetic TULV clades and an overall isolation-by-distance pattern in virus sequences were detected, while at the small scale (<4 km) this depended on the study area. In combination with an overall delayed density dependence, our results highlight that frequent, localized bottleneck events for the common vole and TULV do occur and can be offset by local recolonization dynamics.…
MetadatenAuthor details: | Sabrina Schmidt, Daniela ReilORCiDGND, Kathrin JeskeORCiD, Stephan DrewesORCiD, Ulrike RosenfeldGND, Stefan Fischer, Nastasja G. Spierling, Anton Labutin, Gerald Heckel, Jens Jacob, Rainer G. UlrichORCiD, Christian ImholtORCiDGND |
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DOI: | https://doi.org/10.3390/v13061132 |
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ISSN: | 1999-4915 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/34208398 |
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Title of parent work (English): | Viruses / Molecular Diversity Preservation International (MDPI) |
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Publisher: | MDPI |
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Place of publishing: | Basel |
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Publication type: | Article |
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Language: | English |
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Date of first publication: | 2021/06/11 |
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Publication year: | 2021 |
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Release date: | 2024/07/05 |
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Tag: | common vole; field vole; hantavirus; molecular evolution; monitoring; phylogeny; population dynamics; rodents; water vole |
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Volume: | 13 |
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Issue: | 6 |
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Article number: | 1132 |
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Number of pages: | 17 |
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Funding institution: | Federal Environment Agency (UBA)University of Buenos Aires [3709 41 401, 3713 48 401]; Federal Ministry of Education and Research (BMBF) within the Research net Zoonotic Infectious Diseases (consortium RoBoPub)Federal Ministry of Education & Research (BMBF) [01KI1721A, 01KI2004A, 01KI2004E]; Robert Koch Institute; German Ministry of Public Health [1362/1-924, 1362/1-980]; Deutsche Forschungsgemeinschaft (SPP 1596, "Ecology and Species Barriers in Emerging Viral Diseases") [UL 405/1-1]; EMIDA ERA-NET project APHAEA [2811ERA117]; Swiss National Science FoundationSwiss National Science Foundation (SNSF)European Commission [31003A_176209]; EUEuropean Commission [FP7-261504 EDENext] |
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Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
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DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Peer review: | Referiert |
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Publishing method: | Open Access / Gold Open-Access |
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| DOAJ gelistet |
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License (German): | CC-BY - Namensnennung 4.0 International |
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