Cardiovascular inflammaging: mechanisms and translational aspects
- Aging is one of the major non-reversible risk factors for several chronic diseases, including cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause of multimorbidity, disability, and frailty (decreased physical activity, fatigue, and weight loss). The underlying cellular mechanisms are complex and consist of multifactorial processes, such as telomere shortening, chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, accumulation of senescent cells, and reduced autophagy. In this review, we focused on the molecular mechanisms and translational aspects of cardiovascular aging-related inflammation, i.e., inflammaging.
| Author details: | Maria Luisa BarcenaORCiD, Muhammad AslamORCiD, Sofya PozdniakovaORCiD, Kristina NormanORCiDGND, Yury LadilovORCiD |
|---|---|
| DOI: | https://doi.org/10.3390/cells11061010 |
| ISSN: | 2073-4409 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/35326461 |
| Title of parent work (English): | Cells |
| Publisher: | MDPI |
| Place of publishing: | Basel |
| Publication type: | Article |
| Language: | English |
| Date of first publication: | 2022/03/16 |
| Publication year: | 2022 |
| Release date: | 2024/06/28 |
| Tag: | cardiac inflammaging; microbiome; mitochondrial homeostasis; vascular senescence |
| Volume: | 11 |
| Issue: | 6 |
| Article number: | 1010 |
| Number of pages: | 15 |
| Funding institution: | German Research Foundation (DFG); Open Access Publication Fund of; Charite-Universitatsmedizin Berlin |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
| Peer review: | Referiert |
| Publishing method: | Open Access / Gold Open-Access |
| DOAJ gelistet | |
| License (German): |  CC-BY - Namensnennung 4.0 International |
