TY  - JOUR
A1  - Barcena, Maria Luisa
A1  - Aslam, Muhammad
A1  - Pozdniakova, Sofya
A1  - Norman, Kristina
A1  - Ladilov, Yury
T1  - Cardiovascular inflammaging: mechanisms and translational aspects
T2  - Cells
N2  - Aging is one of the major non-reversible risk factors for several chronic diseases, including cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause of multimorbidity, disability, and frailty (decreased physical activity, fatigue, and weight loss). The underlying cellular mechanisms are complex and consist of multifactorial processes, such as telomere shortening, chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, accumulation of senescent cells, and reduced autophagy. In this review, we focused on the molecular mechanisms and translational aspects of cardiovascular aging-related inflammation, i.e., inflammaging.
KW  - cardiac inflammaging
KW  - vascular senescence
KW  - mitochondrial homeostasis
KW  - microbiome
Y1  - 2022
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/64409
SN  - 2073-4409
VL  - 11
IS  - 6
PB  - MDPI
CY  - Basel
ER  -