The mechanobiology of zebrafish cardiac valve leaflet formation
- Over a lifetime, rhythmic contractions of the heart provide a continuous flow of blood throughout the body. An essential morphogenetic process during cardiac development which ensures unidirectional blood flow is the formation of cardiac valves. These structures are largely composed of extracellular matrix and of endocardial cells, a specialized population of endothelial cells that line the interior of the heart and that are subjected to changing hemodynamic forces. Recent studies have significantly expanded our understanding of this morphogenetic process. They highlight the importance of the mechanobiology of cardiac valve formation and show how biophysical forces due to blood flow drive biochemical and electrical signaling required for the differentiation of cells to produce cardiac valves.
| Author details: | Alessio PaoliniORCiDGND, Salim Abdelilah-SeyfriedORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1016/j.ceb.2018.05.007 |
| ISSN: | 0955-0674 |
| ISSN: | 1879-0410 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30007126 |
| Title of parent work (English): | Current opinion in cell biology : review articles, recommended reading, bibliography of the world literature |
| Publisher: | Elsevier |
| Place of publishing: | London |
| Publication type: | Review |
| Language: | English |
| Date of first publication: | 2018/07/11 |
| Publication year: | 2018 |
| Release date: | 2021/06/17 |
| Volume: | 55 |
| Number of pages: | 7 |
| First page: | 52 |
| Last Page: | 58 |
| Funding institution: | excellence cluster REBIRTH, SFB958; Deutsche Forschungsgemeinschaft (DFG)German Research Foundation (DFG) [SE2016/7-2, SE2016/10-1] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| Peer review: | Referiert |
