Intracellular oscillations and waves
- Dynamic processes in living cells are highly organized in space and time. Unraveling the underlying molecular mechanisms of spatiotemporal pattern formation remains one of the outstanding challenges at the interface between physics and biology. A fundamental recurrent pattern found in many different cell types is that of self-sustained oscillations. They are involved in a wide range of cellular functions, including second messenger signaling, gene expression, and cytoskeletal dynamics. Here, we review recent developments in the field of cellular oscillations and focus on cases where concepts from physics have been instrumental for understanding the underlying mechanisms. We consider biochemical and genetic oscillators as well as oscillations that arise from chemo-mechanical coupling. Finally, we highlight recent studies of intracellular waves that have increasingly moved into the focus of this research field.
Author details: | Carsten BetaORCiDGND, Karsten KruseORCiDGND |
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DOI: | https://doi.org/10.1146/annurev-conmatphys-031016-025210 |
ISBN: | 978-0-8243-5008-6 |
ISSN: | 1947-5454 |
Title of parent work (English): | Annual review of condensed matter physics |
Publisher: | Annual Reviews |
Place of publishing: | Palo Alto |
Publication type: | Article |
Language: | English |
Date of first publication: | 2017/01/11 |
Publication year: | 2017 |
Release date: | 2023/02/03 |
Tag: | actin waves; biochemical oscillators; chemomechanical coupling; genetic networks; self-sustained oscillations |
Volume: | 8 |
Number of pages: | 26 |
First page: | 239 |
Last Page: | 264 |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik und Astronomie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik |
Peer review: | Referiert |