Minimal intervention strategies in logical signaling networks with ASP
- Proposing relevant perturbations to biological signaling networks is central to many problems in biology and medicine because it allows for enabling or disabling certain biological outcomes. In contrast to quantitative methods that permit fine-grained (kinetic) analysis, qualitative approaches allow for addressing large-scale networks. This is accomplished by more abstract representations such as logical networks. We elaborate upon such a qualitative approach aiming at the computation of minimal interventions in logical signaling networks relying on Kleene's three-valued logic and fixpoint semantics. We address this problem within answer set programming and show that it greatly outperforms previous work using dedicated algorithms.
Author details: | Roland KaminskiORCiD, Torsten SchaubORCiDGND, Anne SiegelORCiDGND, Santiago Videla |
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URN: | urn:nbn:de:kobv:517-opus4-415704 |
DOI: | https://doi.org/10.25932/publishup-41570 |
ISSN: | 1866-8372 |
Title of parent work (English): | Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe |
Publication series (Volume number): | Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (596) |
Publication type: | Postprint |
Language: | English |
Date of first publication: | 2019/02/13 |
Publication year: | 2013 |
Publishing institution: | Universität Potsdam |
Release date: | 2019/02/13 |
Tag: | circuits; models; sets; systems biology; transduction |
Issue: | 4-5 |
Number of pages: | 16 |
First page: | 675 |
Last Page: | 690 |
Source: | Theory and Practice of Logic Programming 13 (2013) 4-5, pp.675–690 DOI 10.1017/S1471068413000422 |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät |
DDC classification: | 0 Informatik, Informationswissenschaft, allgemeine Werke / 00 Informatik, Wissen, Systeme / 004 Datenverarbeitung; Informatik |
Peer review: | Referiert |
Publishing method: | Open Access |
Grantor: | Cambridge University Press (CUP) |
License (German): | Keine öffentliche Lizenz: Unter Urheberrechtsschutz |
External remark: | Bibliographieeintrag der Originalveröffentlichung/Quelle |