Extracellular vesicles
- Osteoporosis is characterized by low bone mass and damage to the bone tissue’s microarchitecture, leading to increased fracture risk. Several studies have provided evidence for associations between psychosocial stress and osteoporosis through various pathways, including the hypothalamic-pituitary-adrenocortical axis, the sympathetic nervous system, and other endocrine factors. As psychosocial stress provokes oxidative cellular stress with consequences for mitochondrial function and cell signaling (e.g., gene expression, inflammation), it is of interest whether extracellular vesicles (EVs) may be a relevant biomarker in this context or act by transporting substances. EVs are intercellular communicators, transfer substances encapsulated in them, modify the phenotype and function of target cells, mediate cell-cell communication, and, therefore, have critical applications in disease progression and clinical diagnosis and therapy. This review summarizes the characteristics of EVs, their role in stress and osteoporosis, and their benefit asOsteoporosis is characterized by low bone mass and damage to the bone tissue’s microarchitecture, leading to increased fracture risk. Several studies have provided evidence for associations between psychosocial stress and osteoporosis through various pathways, including the hypothalamic-pituitary-adrenocortical axis, the sympathetic nervous system, and other endocrine factors. As psychosocial stress provokes oxidative cellular stress with consequences for mitochondrial function and cell signaling (e.g., gene expression, inflammation), it is of interest whether extracellular vesicles (EVs) may be a relevant biomarker in this context or act by transporting substances. EVs are intercellular communicators, transfer substances encapsulated in them, modify the phenotype and function of target cells, mediate cell-cell communication, and, therefore, have critical applications in disease progression and clinical diagnosis and therapy. This review summarizes the characteristics of EVs, their role in stress and osteoporosis, and their benefit as biological markers. We demonstrate that EVs are potential mediators of psychosocial stress and osteoporosis and may be beneficial in innovative research settings.…
Author details: | Yangyang HeORCiDGND, Karin Würtz-KozakORCiDGND, Linn Kristina KühlORCiDGND, Pia-Maria WippertORCiDGND |
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DOI: | https://doi.org/10.3390/ijms22115846 |
ISSN: | 1422-0067 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/34072559 |
Title of parent work (English): | International journal of molecular sciences |
Subtitle (English): | Potential mediators of psychosocial stress contribution to osteoporosis? |
Publisher: | Molecular Diversity Preservation International |
Place of publishing: | Basel |
Publication type: | Article |
Language: | English |
Date of first publication: | 2021/04/23 |
Publication year: | 2021 |
Release date: | 2021/10/19 |
Tag: | allostatic load; bone remodeling; microRNA; osteoblast; osteoclast |
Volume: | 22 |
Issue: | 11 |
Article number: | 5846 |
Number of pages: | 15 |
Funding institution: | Universität Potsdam |
Funding institution: | CHINASCHOLARSHIP COUNCIL China Scholarship Council |
Funding institution: | Deutsche Forschungsgemeinschaft the Open Access Publishing Fund of University of Potsdam |
Funding number: | PA 2021_045 |
Funding number: | 202008430179 |
Organizational units: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Sport- und Gesundheitswissenschaften |
Fakultät für Gesundheitswissenschaften | |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie | |
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
Peer review: | Referiert |
Grantor: | Publikationsfonds der Universität Potsdam |
Publishing method: | Open Access / Gold Open-Access |
License (German): | CC-BY - Namensnennung 4.0 International |
External remark: | Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe ; 1166 |