Perfect anomalous transport of subdiffusive cargos by molecular motors in viscoelastic cytosol
- Multiple experiments show that various submicron particles such as magnetosomes, RNA messengers, viruses, and even much smaller nanoparticles such as globular proteins diffuse anomalously slow in viscoelastic cytosol of living cells. Hence, their sufficiently fast directional transport by molecular motors such as kinesins is crucial for the cell operation. It has been shown recently that the traditional flashing Brownian ratchet models of molecular motors are capable to describe both normal and anomalous transport of such subdiffusing cargos by molecular motors with a very high efficiency. This work elucidates further an important role of mechanochemical coupling in such an anomalous transport. It shows a natural emergence of a perfect subdiffusive ratchet regime due to allosteric effects, where the random rotations of a "catalytic wheel" at the heart of the motor operation become perfectly synchronized with the random stepping of a heavily loaded motor, so that only one ATP molecule is consumed on average at each motor step alongMultiple experiments show that various submicron particles such as magnetosomes, RNA messengers, viruses, and even much smaller nanoparticles such as globular proteins diffuse anomalously slow in viscoelastic cytosol of living cells. Hence, their sufficiently fast directional transport by molecular motors such as kinesins is crucial for the cell operation. It has been shown recently that the traditional flashing Brownian ratchet models of molecular motors are capable to describe both normal and anomalous transport of such subdiffusing cargos by molecular motors with a very high efficiency. This work elucidates further an important role of mechanochemical coupling in such an anomalous transport. It shows a natural emergence of a perfect subdiffusive ratchet regime due to allosteric effects, where the random rotations of a "catalytic wheel" at the heart of the motor operation become perfectly synchronized with the random stepping of a heavily loaded motor, so that only one ATP molecule is consumed on average at each motor step along microtubule. However, the number of rotations made by the catalytic engine and the traveling distance both scale sublinearly in time. Nevertheless, this anomalous transport can be very fast in absolute terms.…
Author details: | Igor GoychukORCiDGND |
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DOI: | https://doi.org/10.1016/j.biosystems.2018.11.004 |
ISSN: | 0303-2647 |
ISSN: | 1872-8324 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30419266 |
Title of parent work (English): | Biosystems : journal of biological and information processing sciences |
Publisher: | Elsevier |
Place of publishing: | Oxford |
Publication type: | Article |
Language: | English |
Year of first publication: | 2019 |
Publication year: | 2019 |
Release date: | 2021/03/26 |
Tag: | Anomalous transport; Brownian motors; Flashing ratchets; Generalized Langevin equation; Memory effects; Multi-dimensional Markovian embedding of non-Markovian dynamics; Subdiffusion; Thermodynamic efficiency; Viscoelasticity |
Volume: | 177 |
Number of pages: | 10 |
First page: | 56 |
Last Page: | 65 |
Funding institution: | Deutsche Forschungsgemeinschaft (German Research Foundation)German Research Foundation (DFG) [GO 2052/3-1] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik und Astronomie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik |
Peer review: | Referiert |
Publishing method: | Open Access / Green Open-Access |