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Sphingosine-1-Phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo
- Dendritic cells (DCs) are the cutting edge in innate and adaptive immunity. The major functions of these antigen presenting cells are the capture, endosomal processing and presentation of antigens, providing them an exclusive ability to provoke adaptive immune responses and to induce and control tolerance. Immature DCs capture and process antigens, migrate towards secondary lymphoid organs where they present antigens to naive T cells in a well synchronized sequence of procedures referred to as maturation. Indeed, recent research indicated that sphingolipids are modulators of essential steps in DC homeostasis. It has been recognized that sphingolipids not only modulate the development of DC subtypes from precursor cells but also influence functional activities of DCs such as antigen capture, and cytokine profiling. Thus, it is not astonishing that sphingolipids and sphingolipid metabolism play a substantial role in inflammatory diseases that are modulated by DCs. Here we highlight the function of sphingosine 1-phosphate (S1P) on DCDendritic cells (DCs) are the cutting edge in innate and adaptive immunity. The major functions of these antigen presenting cells are the capture, endosomal processing and presentation of antigens, providing them an exclusive ability to provoke adaptive immune responses and to induce and control tolerance. Immature DCs capture and process antigens, migrate towards secondary lymphoid organs where they present antigens to naive T cells in a well synchronized sequence of procedures referred to as maturation. Indeed, recent research indicated that sphingolipids are modulators of essential steps in DC homeostasis. It has been recognized that sphingolipids not only modulate the development of DC subtypes from precursor cells but also influence functional activities of DCs such as antigen capture, and cytokine profiling. Thus, it is not astonishing that sphingolipids and sphingolipid metabolism play a substantial role in inflammatory diseases that are modulated by DCs. Here we highlight the function of sphingosine 1-phosphate (S1P) on DC homeostasis and the role of SIP and SW metabolism in inflammatory diseases.…
Author details: | Olga Arlt, Anja Schwiebs, Lukasz JaptokGND, Katja Rueger, Elisabeth Katzy, Burkhard KleuserORCiDGND, Heinfried H. Radeke |
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DOI: | https://doi.org/10.1159/000362982 |
ISSN: | 1015-8987 |
ISSN: | 1421-9778 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/24977479 |
Title of parent work (English): | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology |
Publisher: | Karger |
Place of publishing: | Basel |
Publication type: | Review |
Language: | English |
Year of first publication: | 2014 |
Publication year: | 2014 |
Release date: | 2017/03/27 |
Tag: | Dendritic cells; Fingolimod; IL-12; Inflammation; Sphingosine-1-phosphate |
Volume: | 34 |
Issue: | 1 |
Number of pages: | 18 |
First page: | 27 |
Last Page: | 44 |
Funding institution: | German Research Foundation (DFG) [RA 525/10-1, SFB1039] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
Peer review: | Referiert |
Publishing method: | Open Access |