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The Epileptic Thalamocortical Network is a Macroscopic Self-Sustained Oscillator: Evidence from Frequency-Locking Experiments in Rat Brains
- The rhythmic activity observed in nervous systems, in particular in epilepsies and Parkinson's disease, has often been hypothesized to originate from a macroscopic self-sustained neural oscillator. However, this assumption has not been tested experimentally. Here we support this viewpoint with in vivo experiments in a rodent model of absence seizures, by demonstrating frequency locking to external periodic stimuli and finding the characteristic Arnold tongue. This result has important consequences for developing methods for the control of brain activity, such as seizure cancellation.
| Author details: | Jose Luis Perez-Velazquez, Ramon Guevara Erra, Michael RosenblumORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1038/srep08423 |
| ISSN: | 2045-2322 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/25672543 |
| Title of parent work (English): | Scientific reports |
| Publisher: | Nature Publ. Group |
| Place of publishing: | London |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2015 |
| Publication year: | 2015 |
| Release date: | 2017/03/27 |
| Volume: | 5 |
| Number of pages: | 7 |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik und Astronomie |
| Peer review: | Referiert |
| Publishing method: | Open Access |
