Karin Wuertz-Kozak, Martin Roszkowski, Elena Cambria, Andrea Block, Gisela A. Kuhn, Thea Abele, Wolfgang Hitzl, David Drießlein, Ralph Müller, Michael A. Rapp, Isabelle M. Mansuy, Eva M. J. Peters, Pia-Maria Wippert
- Bone pathology is frequent in stressed individuals. A comprehensive examination of mechanisms linking life stress, depression and disturbed bone homeostasis is missing. In this translational study, mice exposed to early life stress (MSUS) were examined for bone microarchitecture (μCT), metabolism (qPCR/ELISA), and neuronal stress mediator expression (qPCR) and compared with a sample of depressive patients with or without early life stress by analyzing bone mineral density (BMD) (DXA) and metabolic changes in serum (osteocalcin, PINP, CTX-I). MSUS mice showed a significant decrease in NGF, NPYR1, VIPR1 and TACR1 expression, higher innervation density in bone, and increased serum levels of CTX-I, suggesting a milieu in favor of catabolic bone turnover. MSUS mice had a significantly lower body weight compared to control mice, and this caused minor effects on bone microarchitecture. Depressive patients with experiences of childhood neglect also showed a catabolic pattern. A significant reduction in BMD was observed in depressive patientsBone pathology is frequent in stressed individuals. A comprehensive examination of mechanisms linking life stress, depression and disturbed bone homeostasis is missing. In this translational study, mice exposed to early life stress (MSUS) were examined for bone microarchitecture (μCT), metabolism (qPCR/ELISA), and neuronal stress mediator expression (qPCR) and compared with a sample of depressive patients with or without early life stress by analyzing bone mineral density (BMD) (DXA) and metabolic changes in serum (osteocalcin, PINP, CTX-I). MSUS mice showed a significant decrease in NGF, NPYR1, VIPR1 and TACR1 expression, higher innervation density in bone, and increased serum levels of CTX-I, suggesting a milieu in favor of catabolic bone turnover. MSUS mice had a significantly lower body weight compared to control mice, and this caused minor effects on bone microarchitecture. Depressive patients with experiences of childhood neglect also showed a catabolic pattern. A significant reduction in BMD was observed in depressive patients with childhood abuse and stressful life events during childhood. Therefore, future studies on prevention and treatment strategies for both mental and bone disease should consider early life stress as a risk factor for bone pathologies.…
MetadatenAuthor details: | Karin Wuertz-KozakORCiDGND, Martin RoszkowskiORCiD, Elena CambriaORCiD, Andrea BlockORCiDGND, Gisela A. Kuhn, Thea Abele, Wolfgang HitzlORCiD, David DrießleinORCiD, Ralph MüllerORCiD, Michael A. RappORCiDGND, Isabelle M. MansuyORCiDGND, Eva M. J. PetersORCiD, Pia-Maria WippertORCiDGND |
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DOI: | https://doi.org/10.3390/ijms21186634 |
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ISSN: | 1422-0067 |
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Title of parent work (English): | International Journal of Molecular Sciences |
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Publisher: | Molecular Diversity Preservation International |
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Place of publishing: | Basel |
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Publication type: | Article |
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Language: | English |
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Date of first publication: | 2020/09/10 |
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Publication year: | 2020 |
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Release date: | 2020/12/09 |
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Tag: | bone mineral density; bone pathologies; childhood; neuroendocrine; osteoporosis; psychosocial stress |
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Volume: | 21 |
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Issue: | 18 |
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Number of pages: | 24 |
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Funding institution: | Universität Potsdam |
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Funding number: | PA 2020_101 |
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Organizational units: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften |
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DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
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| 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
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Peer review: | Referiert |
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Grantor: | Publikationsfonds der Universität Potsdam |
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Publishing method: | Open Access / Gold Open-Access |
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License (German): | CC-BY - Namensnennung 4.0 International |
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External remark: | Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Humanwissenschaftliche Reihe ; 670 |
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