Lili Chan, Kumardeep Chaudhary, Aparna Saha, Kinsuk Chauhan, Akhil Vaid, Shan Zhao, Ishan Paranjpe, Sulaiman Somani, Felix Richter, Riccardo Miotto, Anuradha Lala, Arash Kia, Prem Timsina, Li Li, Robert Freeman, Rong Chen, Jagat Narula, Allan C. Just, Carol Horowitz, Zahi Fayad, Carlos Cordon-Cardo, Eric Schadt, Matthew A. Levin, David L. Reich, Valentin Fuster, Barbara Murphy, John C. He, Alexander W. Charney, Erwin Böttinger, Benjamin Glicksberg, Steven G. Coca, Girish N. Nadkarni
- Background:
Early reports indicate that AKI is common among patients with coronavirus disease 2019 (COVID-19) and associatedwith worse outcomes. However, AKI among hospitalized patients with COVID19 in the United States is not well described.
Methods:
This retrospective, observational study involved a review of data from electronic health records of patients aged >= 18 years with laboratory-confirmed COVID-19 admitted to the Mount Sinai Health System from February 27 to May 30, 2020. We describe the frequency of AKI and dialysis requirement, AKI recovery, and adjusted odds ratios (aORs) with mortality.
Results:
Of 3993 hospitalized patients with COVID-19, AKI occurred in 1835 (46%) patients; 347 (19%) of the patientswith AKI required dialysis. The proportionswith stages 1, 2, or 3 AKIwere 39%, 19%, and 42%, respectively. A total of 976 (24%) patients were admitted to intensive care, and 745 (76%) experienced AKI. Of the 435 patients with AKI and urine studies, 84% had proteinuria, 81% had hematuria, and 60% hadBackground:
Early reports indicate that AKI is common among patients with coronavirus disease 2019 (COVID-19) and associatedwith worse outcomes. However, AKI among hospitalized patients with COVID19 in the United States is not well described.
Methods:
This retrospective, observational study involved a review of data from electronic health records of patients aged >= 18 years with laboratory-confirmed COVID-19 admitted to the Mount Sinai Health System from February 27 to May 30, 2020. We describe the frequency of AKI and dialysis requirement, AKI recovery, and adjusted odds ratios (aORs) with mortality.
Results:
Of 3993 hospitalized patients with COVID-19, AKI occurred in 1835 (46%) patients; 347 (19%) of the patientswith AKI required dialysis. The proportionswith stages 1, 2, or 3 AKIwere 39%, 19%, and 42%, respectively. A total of 976 (24%) patients were admitted to intensive care, and 745 (76%) experienced AKI. Of the 435 patients with AKI and urine studies, 84% had proteinuria, 81% had hematuria, and 60% had leukocyturia. Independent predictors of severe AKI were CKD, men, and higher serum potassium at admission. In-hospital mortality was 50% among patients with AKI versus 8% among those without AKI (aOR, 9.2; 95% confidence interval, 7.5 to 11.3). Of survivors with AKI who were discharged, 35% had not recovered to baseline kidney function by the time of discharge. An additional 28 of 77 (36%) patients who had not recovered kidney function at discharge did so on posthospital follow-up.
Conclusions:
AKI is common among patients hospitalized with COVID-19 and is associated with high mortality. Of all patients with AKI, only 30% survived with recovery of kidney function by the time of discharge.…
MetadatenAuthor details: | Lili Chan, Kumardeep ChaudharyORCiD, Aparna Saha, Kinsuk ChauhanORCiD, Akhil Vaid, Shan Zhao, Ishan Paranjpe, Sulaiman SomaniORCiD, Felix RichterORCiD, Riccardo Miotto, Anuradha Lala, Arash KiaORCiD, Prem Timsina, Li LiORCiD, Robert FreemanORCiD, Rong Chen, Jagat Narula, Allan C. Just, Carol Horowitz, Zahi Fayad, Carlos Cordon-Cardo, Eric Schadt, Matthew A. Levin, David L. Reich, Valentin FusterORCiD, Barbara Murphy, John C. He, Alexander W. Charney, Erwin BöttingerORCiDGND, Benjamin GlicksbergORCiD, Steven G. CocaORCiD, Girish N. NadkarniORCiD |
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DOI: | https://doi.org/10.1681/ASN.2020050615 |
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ISSN: | 1046-6673 |
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ISSN: | 1533-3450 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/32883700 |
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Title of parent work (English): | Journal of the American Society of Nephrology : JASN |
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Publisher: | American Society of Nephrology |
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Place of publishing: | Washington |
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Publication type: | Article |
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Language: | English |
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Date of first publication: | 2021/12/29 |
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Publication year: | 2021 |
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Creating corporation: | Mt Sinai COVID Informatics Ct |
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Release date: | 2024/01/10 |
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Tag: | COVID-19; acute renal failure; clinical nephrology; dialysis |
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Volume: | 32 |
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Issue: | 1 |
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Number of pages: | 10 |
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First page: | 151 |
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Last Page: | 160 |
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Organizational units: | An-Institute / Hasso-Plattner-Institut für Digital Engineering gGmbH |
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DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Peer review: | Referiert |
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Publishing method: | Open Access / Bronze Open-Access |
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