Transient superdiffusion of polydisperse vacuoles in highly motile amoeboid cells
- We perform a detailed statistical analysis of diffusive trajectories of membrane-enclosed vesicles (vacuoles) in the supercrowded cytoplasm of living Acanthamoeba castellanii cells. From the vacuole traces recorded in the center-of-area frame of moving amoebae, we examine the statistics of the time-averaged mean-squared displacements of vacuoles, their generalized diffusion coefficients and anomalous scaling exponents, the ergodicity breaking parameter, the non-Gaussian features of displacement distributions of vacuoles, the displacement autocorrelation function, as well as the distributions of speeds and positions of vacuoles inside the amoeba cells. Our findings deliver novel insights into the internal dynamics of cellular structures in these infectious pathogens. Published under license by AIP Publishing.
| Author details: | Samudrajit ThapaORCiDGND, Nils LukatORCiD, Christine Selhuber-UnkelORCiDGND, Andrey G. CherstvyORCiD, Ralf MetzlerORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1063/1.5086269 |
| ISSN: | 0021-9606 |
| ISSN: | 1089-7690 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30981236 |
| Title of parent work (English): | The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr |
| Publisher: | American Institute of Physics |
| Place of publishing: | Melville |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2019 |
| Publication year: | 2019 |
| Release date: | 2021/06/21 |
| Volume: | 150 |
| Issue: | 14 |
| Number of pages: | 18 |
| Funding institution: | Deutsche Forschungsgemeinschaft (DFG)German Research Foundation (DFG) [ME 1535/6-1, ME 1535/7-1]; Foundation for Polish Science within an Alexander von Humboldt Polish Honorary Research Fellowship; Deutscher Akademischer Austauschdienst (DAAD)Deutscher Akademischer Austausch Dienst (DAAD) [57214224]; DFG through the Collaborative Research Center [CRC 1261] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik und Astronomie |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik |
| Peer review: | Referiert |
| Publishing method: | Open Access / Green Open-Access |
