Bacterial Molybdoenzymes
- The biogenesis of molybdoenzymes is a cytoplasmic event requiring both the folded apoenzymes and the matured molybdenum cofactor. The structure and the complexity of the molybdenum cofactor varies in each molybdoenzyme family and consequently different accessory proteins are required for the maturation of the respective enzymes. Thus, for enzymes of both the DMSO reductase and xanthine oxidase families, specific chaperones exist which are dedicated to increase the stability and the folding of specific members of each family. In this review, we describe the role of these chaperones for molybdoenzyme maturation. We present a model which describes step by step the mechanism of the maturation of representative molybdoenzymes from each family.
| Author details: | Silke LeimkühlerORCiDGND, Olivier N. LemaireORCiD, Chantal Iobbi-NivolORCiD |
|---|---|
| DOI: | https://doi.org/10.1039/9781782623915-00117 |
| ISBN: | 978-1-78262-391-5 |
| ISBN: | 978-1-78262-089-1 |
| Title of parent work (English): | Molybdenum and tungsten enzymes : biochemistry |
| Subtitle (German): | Chaperones, Assembly and Insertion |
| Publisher: | Royal Society of Chemistry |
| Place of publishing: | Cambridge |
| Publication type: | Article |
| Language: | English |
| Date of first publication: | 2016/09/28 |
| Publication year: | 2017 |
| Release date: | 2022/09/30 |
| Volume: | 5 |
| Number of pages: | 26 |
| First page: | 117 |
| Last Page: | 142 |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| Peer review: | Referiert |
