A RADD approach to probing AAA plus protein function
- AAA+ proteins (ATPases associated with various cellular activities) catalyze the energy-dependent movement or rearrangement of macromolecules. A new study addresses the important question of how to design a selective chemical inhibitor for specific proteins in this diverse superfamily. The powerful chemical genetics approach adds to a growing toolbox of applications that allow dissection of the functions of distinct AAA+ proteins in vivo, facilitating the first steps toward effective drug development.
| Author details: | Saša PetrovićORCiDGND, Petra WendlerORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1038/s41594-021-00579-5 |
| ISSN: | 1545-9993 |
| ISSN: | 1545-9985 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/33782616 |
| Title of parent work (English): | Nature structural & molecular biology |
| Publisher: | Nature Publishing Group |
| Place of publishing: | Berlin |
| Publication type: | Article |
| Language: | English |
| Date of first publication: | 2021/03/29 |
| Publication year: | 2021 |
| Release date: | 2023/01/12 |
| Volume: | 28 |
| Issue: | 4 |
| Number of pages: | 2 |
| First page: | 329 |
| Last Page: | 330 |
| Funding institution: | Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [WE4628/3-1] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| Peer review: | Referiert |
