Red blood cell templated polyelectrolyte capsules : a novel vehicle for the stable encapsulation of DNA and proteins
- A novel method for the encapsulation of biomacromolecules, such as nucleic acids and proteins, into polyelectrolyte microcapsules is described. Fluorescence-labelled double-stranded DNA and human serum albumin (HSA) are used as model substances for encapsulation in hollow microcapsules templated on human erythrocytes. The encapsulation procedure involves an intermediate drying C, step. The accumulation of DNA and HSA in the capsules is observed by confocal laser scanning microscopy, UV spectroscopy, and flourimetry. The mechanism of encapsulation is discussed
| Author details: | Oliver Kreft, Radostina Georgieva, Hans Bäumler, Martin SteupORCiDGND, Bernd Müller-RöberORCiDGND, Gleb B. Sukhorukov, Helmuth MöhwaldGND |
|---|---|
| URL: | http://www3.interscience.wiley.com/cgi-bin/jhome/10003270 |
| DOI: | https://doi.org/10.1002/marc.200500777 |
| ISSN: | 1022-1336 |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2006 |
| Publication year: | 2006 |
| Release date: | 2017/03/25 |
| Source: | Macromolecular rapid communications. - ISSN 1022-1336. - 27 (2006), 6, S. 435 - 440 |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| Peer review: | Referiert |
| Publishing method: | Open Access |
