The future of ancient DNA: Technical advances and conceptual shifts
- Technological innovations such as next generation sequencing and DNA hybridisation enrichment have resulted in multi-fold increases in both the quantity of ancient DNA sequence data and the time depth for DNA retrieval. To date, over 30 ancient genomes have been sequenced, moving from 0.7x coverage (mammoth) in 2008 to more than 50x coverage (Neanderthal) in 2014. Studies of rapid evolutionary changes, such as the evolution and spread of pathogens and the genetic responses of hosts, or the genetics of domestication and climatic adaptation, are developing swiftly and the importance of palaeogenomics for investigating evolutionary processes during the last million years is likely to increase considerably. However, these new datasets require new methods of data processing and analysis, as well as conceptual changes in interpreting the results. In this review we highlight important areas of future technical and conceptual progress and discuss research topics in the rapidly growing field of palaeogenomics.
Author details: | Michael HofreiterORCiDGND, Johanna L. A. PaijmansORCiDGND, Helen Goodchild, Camilla F. Speller, Axel BarlowORCiDGND, Gloria M. González-FortesORCiD, Jessica A. Thomas, Arne Ludwig, Matthew J. CollinsORCiD |
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DOI: | https://doi.org/10.1002/bies.201400160 |
ISSN: | 0265-9247 |
ISSN: | 1521-1878 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/25413709 |
Title of parent work (English): | Bioessays : ideas that push the boundaries |
Publisher: | Wiley-Blackwell |
Place of publishing: | Hoboken |
Publication type: | Article |
Language: | English |
Year of first publication: | 2015 |
Publication year: | 2015 |
Release date: | 2017/03/27 |
Tag: | ancient DNA; hybridisation capture; multi-locus data; next generation sequencing (NGS); palaeogenomics; population genomics |
Volume: | 37 |
Issue: | 3 |
Number of pages: | 10 |
First page: | 284 |
Last Page: | 293 |
Funding institution: | DFG [DFG 852/7-4]; Marie-Curie grant ORCA [FP7-PEOPLE-2011-IIF 299075]; ERC [310763 GeneFlow] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
Peer review: | Referiert |
External remark: | Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe ; 908 |