Fabian Eichelmann, Matthias Bernd Schulze, Clemens Wittenbecher, Juliane Menzel, Cornelia Weikert, Romina di Giuseppe, Ronald Biemann, Berend Isermann, Andreas Fritsche, Heiner Boeing, Krasimira Aleksandrova
- IMPORTANCE Inflammatory processes have been suggested to have an important role in colorectal cancer (CRC) etiology. Chemerin is a recently discovered inflammatory biomarker thought to exert chemotactic, adipogenic, and angiogenic functions. However, its potential link with CRC has not been sufficiently explored. OBJECTIVE To evaluate the prospective association of circulating plasma chemerin concentrations with incident CRC. DESIGN, SETTING, AND PARTICIPANTS Prospective case-cohort study based on 27 548 initially healthy participants from the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam cohort who were followed for up to 16 years. Baseline study information and samples were collected between August 23, 1994, and September 25, 1998. Recruitment was according to random registry sampling from the geographical area of Potsdam, Germany, and surrounding municipalities. The last date of study follow-up was May 10, 2010. Statistical analysis was conducted in 2018. MAIN OUTCOMES AND MEASURES Incident CRC, colonIMPORTANCE Inflammatory processes have been suggested to have an important role in colorectal cancer (CRC) etiology. Chemerin is a recently discovered inflammatory biomarker thought to exert chemotactic, adipogenic, and angiogenic functions. However, its potential link with CRC has not been sufficiently explored. OBJECTIVE To evaluate the prospective association of circulating plasma chemerin concentrations with incident CRC. DESIGN, SETTING, AND PARTICIPANTS Prospective case-cohort study based on 27 548 initially healthy participants from the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam cohort who were followed for up to 16 years. Baseline study information and samples were collected between August 23, 1994, and September 25, 1998. Recruitment was according to random registry sampling from the geographical area of Potsdam, Germany, and surrounding municipalities. The last date of study follow-up was May 10, 2010. Statistical analysis was conducted in 2018. MAIN OUTCOMES AND MEASURES Incident CRC, colon cancer, and rectal cancer. Baseline chemerin plasma concentrations were measured by enzyme-linked immunosorbent assay. CONCLUSIONS AND RELEVANCE This study found that the association between chemerin concentration and the risk of incident CRC was linear and independent of established CRC risk factors. Further studies are warranted to evaluate chemerin as a novel immune-inflammatory agent in colorectal carcinogenesis.…
MetadatenAuthor details: | Fabian EichelmannORCiDGND, Matthias Bernd SchulzeORCiDGND, Clemens WittenbecherORCiDGND, Juliane MenzelORCiD, Cornelia WeikertORCiDGND, Romina di Giuseppe, Ronald Biemann, Berend Isermann, Andreas Fritsche, Heiner BoeingORCiDGND, Krasimira AleksandrovaORCiDGND |
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DOI: | https://doi.org/10.1001/jamanetworkopen.2019.0896 |
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ISSN: | 2574-3805 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30901045 |
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Title of parent work (English): | JAMA network open |
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Publisher: | American Veterinary Medical Association |
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Place of publishing: | Chicago |
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Publication type: | Article |
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Language: | English |
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Date of first publication: | 2019/03/22 |
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Publication year: | 2019 |
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Release date: | 2021/03/22 |
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Volume: | 2 |
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Issue: | 3 |
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Number of pages: | 14 |
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Funding institution: | Federal Ministry of Science (Germany) [01 EA 9401]; European UnionEuropean Union (EU) [SOC 95201408 05 F02]; German Cancer AidDeutsche Krebshilfe [70-2488-Ha I]; European CommunityEuropean Community (EC) [SOC 98200769 05 F02]; German Ministry of Education and Research (BMBF)Federal Ministry of Education & Research (BMBF) [82DZD00302]; State of Brandenburg (DZD); German Research Foundation (DFG)German Research Foundation (DFG) [AL 1784/3-1] |
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Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
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DDC classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
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Peer review: | Referiert |
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Publishing method: | Open Access / Gold Open-Access |
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| DOAJ gelistet |
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License (German): | CC-BY - Namensnennung 4.0 International |
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