Giulia Zancolli, Timothy G. Baker, Axel Barlow, Rebecca K. Bradley, Juan J. Calvete, Kimberley C. Carter, Kaylah de Jager, John Benjamin Owens, Jenny Forrester Price, Libia Sanz, Amy Scholes-Higham, Liam Shier, Liam Wood, Catharine E. Wüster, Wolfgang Wüster
- Venomous snakes often display extensive variation in venom composition both between and within species. However, the mechanisms underlying the distribution of different toxins and venom types among populations and taxa remain insufficiently known. Rattlesnakes (Crotalus, Sistrurus) display extreme inter-and intraspecific variation in venom composition, centered particularly on the presence or absence of presynaptically neurotoxic phospholipases A2 such as Mojave toxin (MTX). Interspecific hybridization has been invoked as a mechanism to explain the distribution of these toxins across rattlesnakes, with the implicit assumption that they are adaptively advantageous. Here, we test the potential of adaptive hybridization as a mechanism for venom evolution by assessing the distribution of genes encoding the acidic and basic subunits of Mojave toxin across a hybrid zone between MTX-positive Crotalus scutulatus and MTX-negative C. viridis in southwestern New Mexico, USA. Analyses of morphology, mitochondrial and single copy-nuclear genesVenomous snakes often display extensive variation in venom composition both between and within species. However, the mechanisms underlying the distribution of different toxins and venom types among populations and taxa remain insufficiently known. Rattlesnakes (Crotalus, Sistrurus) display extreme inter-and intraspecific variation in venom composition, centered particularly on the presence or absence of presynaptically neurotoxic phospholipases A2 such as Mojave toxin (MTX). Interspecific hybridization has been invoked as a mechanism to explain the distribution of these toxins across rattlesnakes, with the implicit assumption that they are adaptively advantageous. Here, we test the potential of adaptive hybridization as a mechanism for venom evolution by assessing the distribution of genes encoding the acidic and basic subunits of Mojave toxin across a hybrid zone between MTX-positive Crotalus scutulatus and MTX-negative C. viridis in southwestern New Mexico, USA. Analyses of morphology, mitochondrial and single copy-nuclear genes document extensive admixture within a narrow hybrid zone. The genes encoding the two MTX subunits are strictly linked, and found in most hybrids and backcrossed individuals, but not in C. viridis away from the hybrid zone. Presence of the genes is invariably associated with presence of the corresponding toxin in the venom. We conclude that introgression of highly lethal neurotoxins through hybridization is not necessarily favored by natural selection in rattlesnakes, and that even extensive hybridization may not lead to introgression of these genes into another species.…
MetadatenAuthor details: | Giulia Zancolli, Timothy G. Baker, Axel BarlowORCiDGND, Rebecca K. Bradley, Juan J. Calvete, Kimberley C. Carter, Kaylah de Jager, John Benjamin Owens, Jenny Forrester Price, Libia Sanz, Amy Scholes-Higham, Liam Shier, Liam Wood, Catharine E. Wüster, Wolfgang Wüster |
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URN: | urn:nbn:de:kobv:517-opus4-407595 |
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Title of parent work (English): | Toxins |
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Subtitle (English): | a test, using a crotalus scutulatus × viridis hybrid zone in southwestern New Mexico |
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Publication series (Volume number): | Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (443) |
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Publication type: | Postprint |
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Language: | English |
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Date of first publication: | 2018/06/19 |
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Publication year: | 2016 |
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Publishing institution: | Universität Potsdam |
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Release date: | 2018/06/19 |
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Tag: | Crotalus; Mojave toxin; adaptation; evolution; hybridization; introgression; molecular evolution; venom |
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Number of pages: | 16 |
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Source: | MDPI Toxins 8 (2016); DOI: 10.3390/toxins8060188 |
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Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät |
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| Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
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DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Peer review: | Referiert |
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Publishing method: | Open Access |
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Grantor: | Multidisciplinary Digital Publishing Institute (MDPI) |
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License (German): | CC-BY - Namensnennung 4.0 International |
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