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Institute
- Extern (329) (remove)
A degree course in IT and business administration solely for women (FIW) has been offered since 2009 at the HTW Berlin – University of Applied Sciences. This contribution discusses student motivations for enrolling in such a women only degree course and gives details of our experience over recent years. In particular, the approach to attracting new female students is described and the composition of the intake is discussed. It is shown that the women-only setting together with other factors can attract a new clientele for computer science.
Viele Studierende stoßen im Rahmen ihres Informatikstudiums auf Probleme und benötigen individuell bedarfsgerechte Unterstützung, um beispielsweise trotz gewisser Startschwierigkeiten ihr Studium erfolgreich zu Ende zu führen. In die damit verbundene Lern- bzw. Studienberatung fließen Empfehlungen zur weiteren Studienverlaufsplanung ein. Anhand einer Datenanalyse über den Prüfungsleistungsdaten der Studierenden überprüfen wir die hinter diesen Empfehlungen liegenden Hypothesen und leiten aus den dabei gewonnenen Erkenntnissen Konsequenzen für die Beratung ab.
Insgesamt zeigt sich, dass sich nach den ersten Semestern ein mittlerer Bereich von Studierenden identifizieren lässt, bei denen Studienabbruch und Studienerfolg etwa gleich wahrscheinlich sind. Für diese Personengruppe ist Beratungsbedarf dringend gegeben. Gleichzeitig stößt die Datenanalyse auch an gewisse Grenzen, denn es zeigen sich insgesamt keine echt trennscharfen Muster, die frühzeitig im Studium eindeutig Erfolg oder Misserfolg prognostizieren. Dieses Ergebnis ist jedoch insofern erfreulich, als es bedeutet, dass jede:r Studierende:r auch nach einem suboptimalen Start ins Studium noch eine Chance auf einen Abschluss hat.
Informatikstudiengänge verzeichnen hohe Abbruchquoten innerhalb der ersten beiden Semester, die häufig mit Leistungsdefiziten oder Motivationsproblemen begründet werden. Eine Ursache dafür, dass trotz intensiver Bemühungen um bessere Lehre und motivationsfördernde Maßnahmen diese Situation imWesentlichen unverändert bleibt, könnte darin liegen, dass nicht die eine Maßnahme oder der eine Ansatz das Problem im Ganzen lösen kann, sondern dass eine heterogene Studierendenschaft vielmehr nach unterschiedlichen Maßnahmen verlangt. Bisher findet sich wenig Forschung zu differenzierten Studierendentypen in der Informatik. Wir stellen in dieser Arbeit einen Ansatz dafür vor, die Heterogenität der Informatikstudierenden zu ergründen, und beschreiben die Ergebnisse erster Versuche mit diesem Ansatz. Um die große Anzahl von Studierenden auf eine überschaubare Anzahl von Typen mit jeweils ähnlichen Bedürfnissen und Erwartungen zu reduzieren, wird dazu die im Produktmanagement bewährte Personas-Methode adaptiert. Im Rahmen einer Befragung von 170 Informatikstudierenden konnten hierzu bereits einige Personas mit unterschiedlichen Merkmalshäufungen ausgearbeitet werden, die eine gute Grundlage darstellen, um auf dieser Basis differenzierte Interventionen zur Förderung und Motivation der Informatikstudierenden zu entwickeln.
Adaption von Lernwegen in adaptierten Lehrmaterialien für Studierende mit Berufsausbildungsabschluss
(2023)
Obwohl immer mehr Menschen nicht direkt ein Studium aufnehmen, sondern zuvor eine berufliche Ausbildung absolvieren, werden die in der Ausbildung erworbenen Kompetenzen von den Hochschulen inhaltlich und didaktisch meist ignoriert. Ein Ansatz, diese Kompetenzen zu würdigen, ist die formale Anrechnung von mitgebrachten Kompetenzen als (für den Studienabschluss erforderliche) Leistungspunkte. Eine andere Variante ist der Einsatz von speziell für die Zielgruppe der Studierenden mit Vorkenntnissen adaptiertem Lehr-Lernmaterial. Um darüber hinaus individuelle Unterschiede zu berücksichtigen, erlaubt eine weitere Adaption individueller Lernpfade den Lernenden, genau die jeweils fehlenden Kompetenzen zu erwerben. In diesem Beitrag stellen wir die exemplarische Entwicklung derartigen Materials anhand des Kurses „Datenbanken“ für die Zielgruppe der Studierenden mit einer abgeschlossenen Ausbildung zum Fachinformatiker bzw. zur Fachinformatikerin vor.
Viele Informatikstudierende sammeln bereits vor ihrem Studium berufliche Erfahrungen im Informatikbereich, ohne dass diese inhaltlich und didaktisch im Studium berücksichtigt werden. Dieser Beitrag geht der Frage nach, welche Kompetenzen aus beruflichen Vorqualifikationen bei Informatikstudierenden existieren und wie diese in Bezug zu Anerkennungsoptionen gesetzt werden können. Betrachtet werden: die pauschale Anerkennung, die auf erworbenen Zertifikaten beruht; die individuelle Anerkennung, bei der individuell erworbene Kompetenzen nachgewiesen werden; die Adaption von individuellen Lernwegen, die Teilkompetenzen der Studierenden berücksichtigt. Es wird eine Interviewstudie vorgestellt, in der Kompetenzen für ein Sample von Informatikstudierenden mit Vorqualifikation als Fachinformatiker/in erhoben und eine Zuordnung zu den Anerkennungsoptionen vorgenommen wurde. Für die präzisere Gestaltung von Anerkennungsprozessen und zur kritischen Reflexion der eingesetzten hochschuldidaktischen Konzepte wurde eine empirische Basis geschaffen. Die vorhandenen Konzepte richten sich traditionell an Abiturienten/ innen mit sehr geringem Informatikhintergrund und berücksichtigen die tatsächlich existierende Heterogenität der Studienanfänger/innen nicht angemessen. Die Ergebnisse zeigen, dass die Befragten aus ihrer Vorqualifikation relevante fachliche Kompetenzen mitbringen, die mit den Anerkennungsoptionen korrespondieren und deren Weiterentwicklung dienen können. Darüber hinaus werden aus überfachlichen Kompetenzen wie Selbststeuerungskompetenzen weitere Erkenntnisse zur Studiengestaltung gewonnen.
Barrierefreiheit kann durch Methoden der Informatik hergestellt und ausgebaut werden. Dieser eingeladene Beitrag stellt die Anforderungen von Menschen mit den umfangreichsten Benutzererfordernissen an Software vor, die z. B. eigene Schriftsysteme wie Braille und entsprechende taktile Ausgabegeräte verwenden. Assistive Technologien umfassen dabei auch Software verschiedenster Art. Es werden die wichtigsten Kompetenzen dafür vorgestellt. Im Curriculum der Informatik können diese Kompetenzen im Rahmen von speziellen Vorlesungen und Übungen vermittelt werden oder sie werden in die jeweiligen Fachgebiete integriert. Um den Studienbetrieb ebenfalls barrierefrei zu gestalten, sind weitere Anstrengungen notwendig, die Lehrende, Verwaltung und die Hochschulleitung einbeziehen.
Diversity is a term that is broadly used and challenging for informatics research, development and education. Diversity concerns may relate to unequal participation, knowledge and methodology, curricula, institutional planning etc. For a lot of these areas, measures, guidelines and best practices on diversity awareness exist. A systemic, sustainable impact of diversity measures on informatics is still largely missing. In this paper I explore what working with diversity and gender concepts in informatics entails, what the main challenges are and provide thoughts for improvement. The paper includes definitions of diversity and intersectionality, reflections on the disciplinary basis of informatics and practical implications of integrating diversity in informatics research and development. In the final part, two concepts from the social sciences and the humanities, the notion of “third space”/hybridity and the notion of “feminist ethics of care”, serve as a lens to foster more sustainable ways of working with diversity in informatics.
Der neurodegenerativen Erkrankung Morbus Parkinson (MP) liegt der Zerfall von Neuronen in den Basalganglien (BG) zugrunde, der mitunter zu kognitiv-sprachlichen Einschränkungen führt. Dies betrifft beispielsweise die Lautstärkeproduktion und -wahrnehmung. Betroffene sprechen signifikant leiser und weisen eine verringerte Wahrnehmungsspanne für Lautstärke auf. Dieses Wahrnehmungsdefizit und die Tatsache, dass die BG die betroffene neurologische Struktur bei MP sind, lässt eine Beteiligung dieser bei der Lautstärkeverarbeitung von Gesunden vermuten.
Um die Rolle der BG bei der Lautstärkeverarbeitung zu untersuchen, wurde eine generalisierte lineare Modellanalyse durchgeführt. Anhand von fMRT-Daten von gesunden Proband*innen, erhoben von Erb et al. (2020), wurde nach linearen Regressionen zwischen den präsentierten Lautstärkewerten und dem BOLD-Signal in acht BG-Regionen gesucht. Hierfür wurden Daten von 63 Proband*innen im Alter zwischen 18 und 78 Jahren (Durchschnitt: 43,4 Jahre) genutzt.
Im linken und rechten Putamen angrenzend zum Globus pallidus pars externa war eine positive lineare Regression beobachtbar. Eine negative lineare Regression zeigte sich im Kopf des Nucleus caudatus beider Hemisphären.
Teile der BG scheinen somit möglicherweise eine Rolle bei der Verarbeitung von Lautstärke zu spielen. In Bezug auf MP besteht die Möglichkeit, dass ihre neuronale Degeneration mitursächlich für die Wahrnehmungseinschränkungen ist. Dies sowie der Einfluss dieses rezeptiven Lautstärkedefizits auf die produktiven sprachlichen Einschränkungen sollten Gegenstand zukünftiger Untersuchungen sein. Es ist gut möglich, dass die Ursache der produktiven Lautstärkedefizite nicht motorischer, sondern rezeptiver Natur ist. Dies hätte einen großen Einfluss auf künftige sprachtherapeutische Konzepte bei der Behandlung produktiver Sprachstörungen bei MP.
Der Sachverständigenrat zur Begutachtung der Entwicklung im Gesundheitswesen forderte bereits 2007 eine verbesserte Zusammenarbeit der Gesundheitsberufe und beschreibt in seinem Gutachten „Kooperation und Verantwortung als Voraussetzung einer zielorientierten Gesundheitsversorgung“ (S. 25). Mit der vorgestellten Arbeit wird untersucht, welche Modelle der berufsübergreifenden Kooperation in der ambulanten sprachtherapeutischen Praxis Anwendung finden und wie diese Kooperationen von Sprachtherapeut*innen bewertet werden. Zu diesem Zweck wurde ein Online-Fragebogen konzipiert. Anschließend wurden die Antworten von insgesamt 30 teilnehmenden Sprachtherapeut*innen ausgewertet. Dabei wurde deutlich, dass die viel diskutierte und häufig geforderte interprofessionelle Zusammenarbeit in der Praxis nur selten zu finden ist. Vielmehr arbeiten die befragten Sprachtherapeut*innen nach multiprofessionellen Modellen. Es fehlen berufsübergreifende Besprechungen, und der fachliche Austausch ist noch viel zu oft dem Engagement einzelner Personen überlassen. Auch die Bewertung der Kooperationen zeigt Verbesserungspotenzial: Die Befragten bewerteten die Zusammenarbeit mit angrenzenden Berufsgruppen durchschnittlich als „befriedigend“.
In diesem Beitrag werden das Konzept der „Virtuellen Runden Tische“ (ViRuTi) sowie Ergebnisse ihrer Pilotierung und Perspektiven für die Implementierung vorgestellt. Dabei geht es um die ressourcenfreundliche, digitale Umsetzung und niederschwellige Durchführung der ViRuTi. Inklusive Bestrebungen sind fest mit der Notwendigkeit interdisziplinärer Fallbesprechungen verknüpft. Akteure aus Kita, Schule und Gesundheitswesen können mit Bezugspersonen des betreffenden Kindes gemeinsam am runden Tisch Perspektiven austauschen und Entscheidungen treffen, bspw. zur Einleitung und Evaluierung von Sprachförder- oder -therapiemaßnahmen. Eine durch ein Konzept vorgegebene Struktur erleichtert den Austausch und die Fokussierung der Beteiligten auf die Ressourcen und Bedürfnisse des Kindes. Außerdem ist dieser interprofessionelle bzw. transdisziplinäre Austausch auch digital möglich.
Entgegen noch immer bestehender Annahmen schränkt Gebärdensprache, wenn sie frühzeitig und uneingeschränkt zugänglich ist, den Lautspracherwerb nicht ein; sie kann diesen sogar erleichtern. Bimodale Bilingualität beschreibt ein „Sowohl-als-auch“ von Lautsprache und der visuell-gestischen Gebärdensprache in der Sprachentwicklung hörbeeinträchtigter Kinder. Für hörende Eltern von hörbeeinträchtigten Kindern in Deutschland ist der Zugang zu Informationen über bimodale Bilingualität, d. h. deutsche Lautsprache und Deutsche Gebärdensprache (DGS), erschwert. Daher wurde in dieser Arbeit auf Grundlage einer umfassenden Literaturrecherche, Hospitationen und der qualitativen Analyse semi-strukturierter Expert*innen-Interviews ein Informationsflyer konzipiert. Dieser stellt erste wichtige Informationen bereit und zeigt konkrete regionale Anlauf- und Kontaktstellen auf. Ziel ist es, betroffenen Familien die bimodale Bilingualität als alternativen Kommunikationsweg vorzustellen und somit Kindern von Geburt an die Möglichkeit der grenzenlosen Kommunikation zu ermöglichen.
Die Maßnahmen zur Eindämmung der COVID-19-Pandemie gingen mit Schulschließungen und variablen Unterrichtsformen einher, was laut Studienlage zum Thema viele Schüler:innen vor große Herausforderungen gestellt hat und noch immer stellt. Es werden Leistungsabfälle und negative Auswirkungen auf die psychische Gesundheit diskutiert. Da besonders die Lesekompetenz eine grundlegende Ressource für schulische Leistungssituationen ist, soll sie im Fokus dieser Studie stehen.
Die Daten der längsschnittlich angelegten BLab-Studie, die den Erwerbsverlauf von Lese- und Rechtschreibleistungen über die Klassenstufen 1 bis 10 untersucht, wurden dazu genutzt, Unterschiede zwischen den Leseleistungen (operationalisiert aus den normierten und standardisierten Untertests zur Lesekompetenz aus ELFE 1 – 6 und SLRT-II) und vier Skalen des Fragebogens zur Erfassung von schulrelevanten Einstellungen und Sichtweisen von Grundschüler:innen FEESS 3 – 4 (Schuleinstellung, Anstrengungsbereitschaft, Lernfreude und Selbstkonzept) statistisch zu analysieren. Dazu wurden die Testergebnisse von N = 174 Viertklässler:innen zweier Kohorten ausgewertet, von denen eine vom variablen Unterrichtsmodus während der COVID-19-Pandemie betroffen war.
Die Ergebnisse der Gruppenvergleiche stellen sich heterogen dar und müssen differenziert betrachtet werden. Insgesamt scheinen die hier einbezogenen Schüler:innen mit den schulbezogenen Maßnahmen zur Eindämmung der COVID-19-Pandemie gut zurechtgekommen zu sein.
Nach Erkenntnissen der Sprachheilpädagogik bzw. Sprachtherapie laufen logopädische Leistungen derzeit überwiegend isoliert vom Bildungsgeschehen ab. Im sogenannten Pull-Out-Modell der Leistungserbringung gibt es keine räumliche, zeitliche und inhaltliche Verbindung mit dem Unterricht in der Grundschule (Reber, 2012). Eine Verknüpfung beider Leistungsdomänen erscheint aber in Bezug auf eine erfolgreiche Inklusion und Teilhabe von Kindern mit Sprach- und Sprechstörungen äußerst sinnvoll. Im Rahmen der vorliegenden Arbeit wird der Frage nachgegangen, in welcher Quantität und Qualität ein Austausch zwischen beiden Bereichen aus der Sicht von Grundschullehrkräften in Berlin derzeit erfolgt. Für die Untersuchung wurde ein Befragungswerkzeug entwickelt, womit die Perspektive der Lehrkräfte im Rahmen einer onlinegestützten Umfrage untersucht werden kann. Innerhalb einer Pilotierung konnten erste Daten gewonnen werden, die darauf hinweisen, dass es derzeit tatsächlich selten zu einer Zusammenarbeit kommt. Als wichtigste Hürde konnten dabei die fehlenden zeitlichen Ressourcen identifiziert werden. Anhand der Pilotierung konnten Vorschläge für eine verbesserte Anpassung des Befragungstools erarbeitet werden, so dass dieses nun die Grundlage für eine breiter angelegte Untersuchung bietet.
Die alleinige Ursache von Stottern ist weiterhin nicht abschließend geklärt. Auf neurofunktioneller und -morphologischer Ebene zeigen stotternde Personen Abweichungen in den Arealen, welche nicht nur für die Initiierung von sprechmotorischen Programmen, sondern auch für die Produktion und Perzeption von musikalischen Rhythmen zuständig sind. Unterschiede zu flüssigsprechenden Personen treten jedoch nicht nur im verbalen, sondern auch im nonverbal sensomotorischen Bereich auf, was auf eine Störung domänenübergreifender auditiv-motorischer Koordinationsprozesse hindeutet. Ausgehend davon wurde in einigen Studien postuliert, dass dem Störungsbild Stottern ein domänenübergreifendes Rhythmusdefizit zugrunde liegt. Im Gegensatz zu anderen Störungsbildern, welche auch Probleme in rhythmischen Aufgaben aufweisen, gibt es bis dato jedoch keine Intervention, welche dieses Defizit angeht. Es soll untersucht werden, ob ein nonverbales rhythmisches Training bei stotternden Kindern im Alter von zehn bis zwölf Jahren eine Verbesserung der sensomotorischen Synchronisationsfähigkeiten zur Folge hat. Zudem soll erforscht werden, ob es Transfereffekte auf die Sprechmotorik und Sprechflüssigkeit gibt. Für die vorliegende einfach verblindete Pilotstudie sollen 20 Kinder rekrutiert werden. Zehn davon werden randomisiert der Experimentalgruppe zugewiesen, welche das rhythmische Spiel Rhythm Workers über drei Wochen daheim auf einem Tablet spielen sollen. Die Kontrollgruppe spielt ein nicht-rhythmisches Bubble-Shooter-Spiel namens Frozen Bubble. Diese Studie könnte somit den Weg ebnen für technologieunterstützte Rehabilitationsmaßnahmen, welche darauf abzielen die rhythmisch-motorischen Defizite bei Stottern zu lindern.
Bei Kindern mit Sprachentwicklungsstörungen (SES) können sich Symptome auf sprachlich-funktionaler Ebene sehr variabel auf die kommunikative Partizipation im Alltag auswirken. Kommunikative Partizipation wird definiert als sprachlich-kommunikatives Teilnehmen an Lebenssituationen, in denen Wissen, Informationen, Ideen oder Gefühle ausgetauscht werden. Der deutschsprachige ‚Fokus auf den Erfolg der Kommunikation für Kinder unter sechs Jahren‘ (FOCUS©-34-G) ist ein evaluierter Fragebogen zur Fremdeinschätzung der kommunikativen Partizipation von Kindern (1;6 bis 5;11 Jahre). Ziel unserer Studie war die Untersuchung der Auswirkungen einer SES auf die kommunikative Partizipation betroffener Kinder im Alter zwischen 2;0 und 4;11 Jahren anhand des FOCUS©-34-G. Eltern von Kindern mit SES füllten den FOCUS©-34-G sowie einen Demografie-Bogen aus. Es konnten erste Daten von 22 Kindern (16 Jungen) im Alter zwischen 2;7 und 3;11 (M = 3;3 Jahre, SD = 0;4 Jahre) erhoben werden. Im FOCUS©-34-G erreichten Kinder mit SES einen Gesamtwert zwischen 54 und 197 (M = 120.55, SD = 40.91) von 238 maximal möglichen Punkten. Diese Ergebnisse zeigen eine eingeschränkte kommunikative Partizipation von Kindern mit SES, die es in einer ICF-CY-orientierten sprachtherapeutischen Intervention zu beachten gilt. Als klinisches Assessmentinstrument kann der FOCUS©-34-G als Kurzversion des FOCUS©-G als geeignet angesehen werden.
Morbus Parkinson (MP) ist in Europa die zweithäufigste neurodegenerative Erkrankung und durch das Störungsbild der Dysarthrie logopädisch relevant. Die Behandlung einer Dysarthrie erfordert ein hochfrequentes Therapieangebot für eine nachhaltige Verbesserung der kommunikativen Fähigkeiten. Trotz der hohen Prävalenz von Sprechstörungen bei MP nehmen in Deutschland nur etwa 4 % der Betroffenen eine ambulante logopädische Therapie in Anspruch. Die veränderte Selbstwahrnehmung der Patient*innen ist ein zentrales Symptom der Erkrankung, das ein wirksames Eigentraining einschränkt.
Neue Technologien mit integrierter Spracherkennung ermöglichen ein individuelles Training. Im Rahmen des Verbundprojektes HUMAINE (human centered AI network) wird der Prototyp eines auf künstlicher Intelligenz (KI) basierendem Sprechassistenzsystems in einem klinischen Versorgungssetting erprobt und evaluiert. Das Ziel ist, das digitale System in die Regelversorgung zu integrieren. Eine nutzer*innenzentrierte Implementierung ist im Rahmen einer Machbarkeitsstudie geplant, dabei wird der Prototyp ISi-Speech in die bestehende Parkinson-Komplex-Therapie integriert. Im Anschluss an die stationäre Behandlung erfolgt eine zweiwöchige Eigentrainingsphase im häuslichen Setting. Durch Interviews soll die Usability sowie die Anwender*innenakzeptanz aus der therapeutischen Sicht und Patient*innenperspektive erhoben werden. Ziel ist die Entwicklung von Implementierungsstrategien, die zur Entwicklung von nachhaltigen Kompetenzmodellen beitragen.
Durch die erhöhte Therapiefrequenz können verbesserte klinische Ergebnisgrößen wie Sprechverständlichkeit, Lebensqualität und individuell wahrgenommene Kommunikationserfolge erreicht werden. Nur durch die Evaluation digitaler Technologien kann eine dauerhafte Implementierung in die Praxis erfolgen. Neue Technologien können eine sinnvolle Ergänzung zur etablierten Therapie sein und eine Strategie gegen die Unterversorgung durch Heilmittel darstellen.
Dieser Beitrag gibt einen Einblick in die ehrenamtliche Arbeit mit Menschen mit Aphasie und deren Angehörigen. Vor sieben Jahren gründete Romy Steinberg gemeinsam mit ihrem Mann, der selbst von Aphasie betroffen ist, den Chor „AphaSingers”. Jeden Monat findet sich der Chor zu einem Workshop-Tag zusammen, der viel mehr als nur die Gesangsprobe beinhaltet. Partizipation umfasst den Austausch miteinander, schöne gemeinsame Erlebnisse und Zusammenhalt. All dies bietet dieser Chor den Mitgliedern und erntet hierfür viel Anerkennung und Dankbarkeit.
Das von E. Berne für psychotherapeutische Gespräche begründete Konzept der Vertragsarbeit lässt sich gut auf die sprachtherapeutische Arbeit übertragen. Der Kern ist die explizite Formulierung von therapeutischen Nah- und Fernzielen, die Wahl der Therapiemethode sowie die Aufgaben und Verantwortlichkeiten der Beteiligten. Voraussetzung ist die Freiwilligkeit und das Arbeiten auf Augenhöhe. Vertragsarbeit verteilt die Verantwortung für das Gelingen und macht Vorgehensweisen transparent. Sehr zeitgemäß ist die ressourcenorientierte Sichtweise auf das therapeutische Angebot.
Der vorliegende Beitrag stellt die deutsche kurze Version des kommunikativen Partizipationsassessments ‚Fokus auf den Erfolg der Kommunikation für Kinder unter 6 Jahren (FOCUS©-34-G)‘ (Thomas-Stonell et al., 2012a) vor. Es werden die Entwicklung und psychometrische Validierung, Zielsetzung, Durchführung und Auswertung für den konkreten Einsatz in der sprachtherapeutischen Praxis beschrieben.
Die Verbesserung der sozialen Teilhabe eines Kindes ohne ausreichende Lautsprache steht im Fokus der Versorgung mit Unterstützter Kommunikation. Die Schnittstelle Alltag ist für die Intervention mit Unterstützter Kommunikation besonders wichtig, da das unterstützt kommunizierende Kind in seiner alltäglichen Kommunikation extrem abhängig von seinem sozialen Umfeld ist. Die Bezugspersonen müssen die Hilfsmittel und ihre Verwendung gut kennen, Kommunikationssituationen spezifisch gestalten und individuell abgestimmte Sprachlehr- und Kommunikationsstrategien einsetzen. Dass dieser Transfer gelingt, ist Aufgabe der Sprachtherapie. Der Sprachtherapie stehen dazu verschiedene Modelle zur Verfügung: das bio-psycho-soziale Modell der Internationalen Klassifikation der Funktionsfähigkeit, Behinderung und Gesundheit der WHO (ICF) und Modelle, die aus dem Fachgebiet der Unterstützten Kommunikation selbst stammen, wie das Kooperative Partizipationsmodell, Fähigkeitskontinuum und Modell kommunikativer Kompetenz. Die Umsetzung der Modelle in die Praxis wird anhand eines Fallbeispiels veranschaulicht. Letztendlich geht es um die natürliche Nutzung von Unterstützter Kommunikation in echten Kommunikationssituationen und um die langfristige Unterstützung der Entwicklung hin zu Fähigkeiten, selbstinitiiert und unabhängig kommunizieren zu können.
Partizipation meint in diesem Kontext die erfolgreiche mündliche Verständigung im sozialen Miteinander. Unter der Bedingung einer Aphasie verändert sich die Partizipation im Alltag bis hin zur sozialen Isolation. Die Sprachtherapie bietet verschiedene Therapieformate, um dagegen verbale Freiräume zu eröffnen. Bei einer globalen Aphasie werden Interaktionshilfen zur Kompensation von sprachlichen Defiziten systematisch und gezielt eingesetzt. Mein Vorgehen beschreibe ich ausführlich. Bei Restaphasie, bei Patient*innen im erwerbsfähigen Alter ohne Arbeitschancen handelt es sich eher um individuelle Projekte zur Selbständigkeit oder Beschäftigung. Hilfreich ist ein Netzwerk an kollegialen Kontakten. Meine Überlegungen und Daten stammen alle aus meinen Erfahrungen in der eigenen Praxis für Sprachtherapie in Dresden.
Menschen mit Aphasie erleben erhebliche Einbußen in sozialer Teilhabe und Lebensqualität. Peer-to-Peer-Unterstützung durch Selbsthilfeangebote oder Peer-Befriending-Maßnahmen kann sich positiv auf Partizipation und psychisches Wohlbefinden auswirken. Mit dem Projekt shalk konnte gezeigt werden, dass von Betroffenen geleitete Selbsthilfegruppen maßgeblich zu Selbstwerterleben und verbesserter Lebensqualität der Leitungspersonen und der Gruppenteilnehmenden beitragen können. Um einen Austausch zwischen Betroffenen auch jenseits des Gruppensettings zu ermöglichen, können digitale Medien genutzt werden. Im Projekt PeerPAL wird ein für Menschen mit Aphasie angepasstes digitales soziales Netzwerk (Smartphone-App) zur virtuellen Vernetzung und persönlichen Begegnung entwickelt und evaluiert. Erste Daten weisen darauf hin, dass die Betroffenen die App nutzen können und mit Design und Funktionen zufrieden sind. Auswirkungen auf die Lebensqualität werden aktuell untersucht. Sprachtherapeut:innen nehmen in der Peer-to-Peer-Unterstützung insofern eine zentrale Rolle ein, als dass sie Betroffene in entsprechende Angebote einführen und sie mittels abgestufter Begleitung an die eigenständige Nutzung heranführen.
Für eine gelingende Kommunikation und Zusammenarbeit zwischen Therapeut:innen und Eltern sind meines Erachtens zwei Aspekte wesentlich: die therapeutische Haltung/innere Einstellung zur Beziehungsgestaltung auf Seiten der Therapeut:innen sowie ihr Wissen und die Fähigkeiten, Eltern ganz pragmatisch in den therapeutischen Prozess einzubinden.
Die Geschichte der Preußischen Seehandlung als Institut für Handels- und Gewerbeförderung ist nur partiell erforscht. Vor allem für die Jahrzehnte nach 1870, als die Seehandlung zur preußischen Staatsbank wurde, bleibt vieles unbekannt. Mit Alliiertem Kontrollratsbeschluss vom 15. Februar 1947 wurden das Land Preußen und auch die Seehandlung aufgelöst. Die Abwicklung der Geschäfte dauerte bis 1983. Mit dem Restvermögen wurde die heute existierende Stiftung gegründet, die sich der Förderung von Wissenschaft und Forschung, Kunst und Kultur widmet. Die von der Stiftung geförderten Aktivitäten reichen von Wissenschafts- und Literaturstipendien über den Ankauf von Nachlässen und Sammlungen bis hin zu Kulturpreisen, v.a. dem Theaterpreis Berlin.
Vorwort
(2023)
Die Königlich Preußische Seehandlung, nach der heute die „Stiftung Preußische Seehandlung“ benannt ist, besitzt eine lange und vielseitige Geschichte. Der anlässlich des Stiftungsjubiläums erscheinende Band wirft einen Blick auf die Gründungskonstellation 1772, als König Friedrich II. die Gewerbe in Preußen fördern wollte. Er zeichnet die Aktivitäten von Männern an der Spitze der Seehandlung nach, wie Finanzminister Carl August von Struensee und dem unter- nehmerisch denkenden Karrierebeamten Christian Rother.
Das Gebäude der Seehandlung wurde nach 1900 neu erbaut und ist heute in der Berlin-Brandenburgischen Akademie am Gendarmenmarkt lebendige Gegenwart. Die Seehand- lung erhielt von ihren Zeitgenossen im 19. Jahr- hundert ambivalente Urteile. Ein Ausblick auf die Geschichte der Stiftung Preußische Seehandlung seit 1983 zeigt das Bemühen um Kunst- und Kul- turförderung als zentrale Aufgabe.
Im 19. Jahrhundert waren Konversationslexika, wie der Name schon andeutet, dazu gedacht, die Konversation in Salon und Vereinen mit Informationen zu bereichern. In den einzelnen Artikeln wurde auf Präzision, Genauigkeit und Überprüfbarkeit gesetzt, um der Leserschaft auch ein eigenes Urteil zu ermöglichen. Die „Seehandlungs-Societät in Preußen“ oder „Seehandlung, preußische“, wie sie in deutschen Lexika vorkommt, wandelte sich im 19. Jahrhundert zur Staatsbank. In der ersten Hälfte des 19. Jahrhunderts fielen die Urteile der Lexika meist ablehnend aus: Die Seehandlung erschien als eine wirtschaftspolitisch katastrophale Fehlentwicklung. Eine besondere Rolle spielte der Präsident Christian (von) Rother, der die Seehandlung zum selbständigen Unternehmen gemacht hatte. Der Wandel der allgemeinen Lexika in der zweiten Hälfte des 19. Jahrhunderts veränderte auch die Sicht auf die Seehandlung. Die Geschäfte der Bank wurden positiv hervorgehoben, die Beurteilungen verwiesen auf Statistiken und Bilanzen. Der Fokus rückte von den leitenden Personen der Seehandlung hin zum Kampf um Handelsmonopole und den preußischen Landtag als öffentlichem Forum. Das vernichtende Urteil der ersten Hälfte des 19. Jahrhunderts war einer differenzierten Bewertung der Bankentätigkeit gewichen.
Das in Bremen gebaute Handelsschiff Princess Louise, gewissermaßen das Flaggschiff der Preußischen Seehandlung, unternahm zwischen 1825 und 1844 insgesamt sechs Weltumsegelungen. Das Schiff fungierte u. a. als Überbringer diplomatischer Geschenke zwischen Herrschern und Herrscherfamilien. Von der ersten Weltumsegelung brachte es den berühmten Federmantel mit, den der hawai’ianische Monarch Kamehameha III. dem preußischen König Friedrich Wilhelm III. zum Geschenk machte. Bei der zweiten Weltumsegelung wurden wiederum Gaben des preußischen Königs nach Hawai‘i transportiert. Die Princess Louise brachte aber darüber hinaus auch Gebrauchsgegenstände wie Kleidung, Waffen, Körbe, Tongefäße und Fächer aus der Südsee und Südamerika nach Europa. Solche ethnographischen Objekte der Vergangenheit können nicht zuletzt mit und durch zeitgenössische Kunst Fragen an die Gegenwart stellen.
Der Beitrag widmet sich der Baugeschichte des Gebäudes der Preußischen Seehandlung bis zu seinem Abriss und dem Neubau in den Jahren 1901–1903, um dann die Veränderungen dieses Bauwerkes bis in die Gegenwart zu verfolgen. In einem zweiten Schritt wird versucht, die Stellung dieser Gebäude im urbanen Kontext zu verorten. Der dritte Teil rekonstruiert an Beispielen, welch markanten Beitrag die Preußische Seehandlung für die Berliner Museen und insbesondere für die im Berliner Schloss lozierte Kunstkammer wie auch für das Museum für Naturkunde geleistet hat, indem seine Großsegler Meteor und Princess Louise von ihren Weltreisen jeweils reich beladen mit naturkundlichen und völkerkundlichen Exponaten zurückkamen, die durch Austausch oder Kauf oder auch als Geschenk erworben worden waren.
Christian (von) Rother, Chef der Preußischen Seehandlung 1820–1848, ist vermutlich die prägendste Gestalt der Institution im 19. Jahrhundert. Seine Lebensgeschichte als Sohn eines schlesischen Bauern zeugt von sozialem Aufstieg und einer eindrucksvollen Beamtenkarriere. Rother formte die Seehandlung zu einem Konglomerat von gewerblichen Unternehmen, die durch Bankengeschäfte, Chausseebauprogramme und das Engagement des Staates in der Wirtschaftsförderung leistungsstark gemacht werden sollten. Der Erfolg blieb allerdings unterschiedlich. In den 1840er Jahren stießen diese Bemühungen darüber hinaus auf Kritik von unternehmerischen Konkurrenten. Bleibende Bedeutung behauptete eine von Rother gegründete soziale Einrichtung, die in Berlin ansässige Rother-Stiftung für arme und unverheiratete Töchter von Beamten und Offizieren.
Kein anderer Akteur prägte die ersten Dezennien der Preußischen Seehandlung so sehr wie Carl August von Struensee. Als deren Direktor und dann als preußischer Finanzminister initiierte er zwischen 1782 und seinem Tod im Jahr 1804 bereits maßgeblich den langen Transformationsprozess der Seehandlung vom königlichen Wachs- und Salzmonopol hin zu einer Staatsbank, der erst im 20. Jahrhundert zum Abschluss kommen sollte. In dem Beitrag wird Struensee sowohl als Wirtschaftstheoretiker in den ökonomischen Diskursen der Aufklärung zwischen Physiokratie und Frühliberalismus situiert als auch als ein Finanzpolitiker mit konsequent europäischem Handlungshorizont vor dem Hintergrund einer beschleunigten globalen und kolonialen Mächtekonkurrenz porträtiert.
Das Jahr 1772
(2023)
Im Jahr 1772 beschäftigten drei Dinge, die lange Zeit ihre Bedeutung behalten sollten, den preußischen König Friedrich den Großen. Zunächst war dies die Adelsrepublik Polen. Polen beabsichtigte er zusammen mit der Zarin Katharina II. von Russland und Kaiserin Maria Theresia zu zerteilen. Dies geschah am 5. August des Jahres. Der geraubte Landgewinn führte bei Friedrich II. zu wirtschaftlichen Überlegungen. Mit und in den annektierten Gebieten wollte er den preußischen Handel intensivieren, zuvörderst den Salzhandel, und zwar am liebsten mit Spanien, einem Land, mit dem er schon seit geraumer Zeit versuchte, einen Handelsvertrag abzuschließen. Dazu gründete er u. a. die Preußische Seehandlungs-Gesellschaft, die, um sich zu behaupten, verschiedene weitreichende Privilegien erhielt. Ein schneller Erfolg der Bemühungen blieb jedoch aus. Trotz aller gewährten Privilegien florierten die Geschäfte der Seehandlungs-Gesellschaft in den ersten Jahren nach ihrer Gründung nicht in dem erhofften Maß. Zu Lebzeiten des Königs kam auch kein Handelsvertrag mit Spanien zustande. Bis die Seehandlung durch die Vorteile, die sie aus dem annektierten Polen ziehen konnte, profitierte, dauerte es noch einige Jahre.
No evidence of growth impairment after forced migration in Polish school children after World War II
(2023)
Background: Migration is omnipresent. It can come hand in hand with emotional stress which is known to influence the growth of children.
Objective: The aim of this study was to analyse whether type of migration (forced or voluntary) and the geographic direction had influenced the growth of Polish children after World War II.
Sample and Methods: A sub dataset of 2,208 individuals between the ages of 2-20, created from data of the 2nd Polish Anthropological Survey carried out in 1966–1969, including anthropometrical data and social and demographic information based on questionnaire, was used to analyse migration effects.
Results: No association could be found between the direction of migration and the height of the children. The confidence intervals of the means of all classified migration categories overlap significantly and the effect size of the influence of migration category on height is ds=.140, which is too low to see any effects, even if there were one.
Conclusion: Neither forced nor voluntary migration in Poland after World War II led to a change in height in children of migrating families.
Background: Assessing short-term growth in humans is still fraught with difficulties. Especially when looking for small variations and increments, such as mini growth spurts, high precision instruments or frequent measurements are necessary. Daily measurements however require a lot of effort, both for anthropologists and for the subjects. Therefore, new sophisticated approaches are needed that reduce fluctuations and reveal underlying patterns.
Objectives: Changepoints are abrupt variations in the properties of time series data. In the context of growth, such variations could be variation in mean height. By adjusting the variance and using different growth models, we assessed the ability of changepoint analysis to analyse short-term growth and detect mini growth spurts.
Sample and Methods: We performed Bayesian changepoint analysis on simulated growth data using the bcp package in R. Simulated growth patterns included stasis, linear growth, catch-up growth, and mini growth spurts. Specificity and a normalised variant of the Matthews correlation coefficient (MCC) were used to assess the algorithm’s performance. Welch’s t-test was used to compare differences of the mean.
Results: First results show that changepoint analysis can detect mini growth spurts. However, the ability to detect mini growth spurts is highly dependent on measurement error. Data preparation, such as ranking and rotating time series data, showed negligible improvements. Missing data was an issue and may affect the prediction quality of the classification metrics.
Conclusion: Changepoint analysis is a promising tool to analyse short-term growth. However, further optimisation and analysis of real growth data is needed to make broader generalisations.
Human growth data analysis and statistics – the 5th Gülpe International Student Summer School
(2023)
The Summer School in Gülpe (Ecological Station of the University of Potsdam) offers an exceptional learning opportunity for students to apply their knowledge and skills to real-world problems. With the guidance of experienced human biologists, statisticians, and programmers, students have the unique chance to analyze their own data and gain valuable insights. This interdisciplinary setting not only bridges different research areas but also leads to highly valuable outputs. The progress of students within just a few days is truly remarkable, especially when they are motivated and receive immediate feedback on their questions, problems, and results. The Summer School covers a wide range of topics, with this year’s focus mainly on two areas: understanding the impact of socioeconomic and physiological factors on human development and mastering statistical techniques for analyzing data such as changepoint analysis and the St. Nicolas House Analysis (SNHA) to visualize interacting variables. The latter technique, born out of the Summer School’s emphasis on gaining comprehensive data insights and understanding major relationships, has proven to be a valuable tool for researchers in the field. The articles in this special issue demonstrate that the Summer School in Gülpe stands as a testament to the power of practical learning and collaboration. Students who attend not only gain hands-on experience but also benefit from the expertise of professionals and the opportunity to engage with peers from diverse disciplines.
Twenty-four scientists met for the annual Auxological conference held at Krobielowice castle, Poland, to discuss the diverse influences of the environment and of social behavior on growth following last year’s focus on growth and public health concerns (Hermanussen et al., 2022b). Growth and final body size exhibit marked plastic responses to ecological conditions. Among the shortest are the pygmoid people of Rampasasa, Flores, Indonesia, who still live under most secluded insular conditions. Genetics and nutrition are usually considered responsible for the poor growth in many parts of this world, but evidence is accumulating on the prominent impact of social embedding on child growth. Secular trends not only in the growth of height, but also in body proportions, accompany the secular changes in the social, economic and political conditions, with major influences on the emotional and educational circumstances under which the children grow up (Bogin, 2021). Aspects of developmental tempo and aspects of sports were discussed, and the impact of migration by the example of women from Bangladesh who grew up in the UK. Child growth was considered in particular from the point of view of strategic adjustments of individual size within the network of its social group. Theoretical considerations on network characteristics were presented and related to the evolutionary conservation of growth regulating hypothalamic neuropeptides that have been shown to link behavior and physical growth in the vertebrate species. New statistical approaches were presented for the evaluation of short term growth measurements that permit monitoring child growth at intervals of a few days and weeks.
In this paper, we investigate the continuous version of modified iterative Runge–Kutta-type methods for nonlinear inverse ill-posed problems proposed in a previous work. The convergence analysis is proved under the tangential cone condition, a modified discrepancy principle, i.e., the stopping time T is a solution of ∥𝐹(𝑥𝛿(𝑇))−𝑦𝛿∥=𝜏𝛿+ for some 𝛿+>𝛿, and an appropriate source condition. We yield the optimal rate of convergence.
In this study, we analyze interactions in lake and lake catchment systems of a continuous permafrost area. We assessed colored dissolved organic matter (CDOM) absorption at 440 nm (a(440)(CDOM)) and absorption slope (S300-500) in lakes using field sampling and optical remote sensing data for an area of 350 km(2) in Central Yamal, Siberia. Applying a CDOM algorithm (ratio of green and red band reflectance) for two high spatial resolution multispectral GeoEye-1 and Worldview-2 satellite images, we were able to extrapolate the a()(CDOM) data from 18 lakes sampled in the field to 356 lakes in the study area (model R-2 = 0.79). Values of a(440)(CDOM) in 356 lakes varied from 0.48 to 8.35 m(-1) with a median of 1.43 m(-1). This a()(CDOM) dataset was used to relate lake CDOM to 17 lake and lake catchment parameters derived from optical and radar remote sensing data and from digital elevation model analysis in order to establish the parameters controlling CDOM in lakes on the Yamal Peninsula. Regression tree model and boosted regression tree analysis showed that the activity of cryogenic processes (thermocirques) in the lake shores and lake water level were the two most important controls, explaining 48.4% and 28.4% of lake CDOM, respectively (R-2 = 0.61). Activation of thermocirques led to a large input of terrestrial organic matter and sediments from catchments and thawed permafrost to lakes (n = 15, mean a(440)(CDOM) = 5.3 m(-1)). Large lakes on the floodplain with a connection to Mordy-Yakha River received more CDOM (n = 7, mean a(440)(CDOM) = 3.8 m(-1)) compared to lakes located on higher terraces.
Many widely used observational data sets are comprised of several overlapping instrument records. While data inter-calibration techniques often yield continuous and reliable data for trend analysis, less attention is generally paid to maintaining higher-order statistics such as variance and autocorrelation. A growing body of work uses these metrics to quantify the stability or resilience of a system under study and potentially to anticipate an approaching critical transition in the system. Exploring the degree to which changes in resilience indicators such as the variance or autocorrelation can be attributed to non-stationary characteristics of the measurement process – rather than actual changes in the dynamical properties of the system – is important in this context. In this work we use both synthetic and empirical data to explore how changes in the noise structure of a data set are propagated into the commonly used resilience metrics lag-one autocorrelation and variance. We focus on examples from remotely sensed vegetation indicators such as vegetation optical depth and the normalized difference vegetation index from different satellite sources. We find that time series resulting from mixing signals from sensors with varied uncertainties and covering overlapping time spans can lead to biases in inferred resilience changes. These biases are typically more pronounced when resilience metrics are aggregated (for example, by land-cover type or region), whereas estimates for individual time series remain reliable at reasonable sensor signal-to-noise ratios. Our work provides guidelines for the treatment and aggregation of multi-instrument data in studies of critical transitions and resilience.
Dieser Beitrag beschäftigt sich mit einer problematischen Seite der Samen- und Eizellenspende. Konkret konzentriert er sich auf die Anonymität im Rahmen dieses Verfahrens, die in manchen europäischen Staaten als eine gesetzliche Bedingung festgelegt ist. Es geht um eine Konsequenz der unklaren Regulierung auf EU-Ebene, die es ermöglicht, nationale Vorschriften nach individuellen Präferenzen des Gesetzgebers zu konzipieren. Trotzdem muss auch der menschenrechtliche Kontext berücksichtigt werden, weil die Anonymität des:der Spender:in dazu führt, dass das Kind de facto keine Chancen hat, seine (genetischen oder biologischen) Eltern zu kennen. Im Prinzip verletzt ein solcher Ansatz das Recht des Kindes auf Kenntnis der eigenen Abstammung, das in entsprechenden Menschenrechtskonventionen verankert und in der Judikatur des EGMR interpretiert wurde.
Das Vorsorgeprinzip ist ein mittlerweile weit verbreiteter und etablierter Grundsatz des internationalen und europäischen Umweltrechts. Demnach sollen auch in Situationen wissenschaftlicher Unsicherheit präventive Maßnahmen ergriffen werden, um schwerwiegende Umweltschäden zu vermeiden. Dieser Beitrag untersucht die Rolle des Vorsorgeprinzips im Zusammenhang mit menschenrechtlichen Klimaklagen, die aufgrund langsamer politischer Fortschritte und erfolgreicher Gerichtsentscheidungen zunehmend an Popularität gewinnen.
Zunächst wird ein Überblick über die Entwicklung und den materiellen Gehalt des Vorsorgeprinzips im internationalen und europäischen Recht gegeben. Obwohl das Vorsorgeprinzip seit den 1980er Jahren ein fixer Bestandteil des internationalen Umweltrechts ist, bestehen über dessen genauen Inhalt und Rechtsnatur nach wie vor Kontroversen. Im Unionsrecht wurde das Vorsorgeprinzip insbesondere durch die Rechtsprechung des EuGH konkretisiert.
Im nächsten Teil des Beitrags wird beleuchtet, welche Bedeutung der EGMR dem Vorsorgeprinzip in umweltrechtlichen Fällen bisher zugemessen hat. Hierbei steht die Entscheidung Tǎtar gegen Rumänien im Mittelpunkt. Gegenstand dieser Entscheidung war der Goldabbau in der rumänischen Stadt Baia Mare, der unter anderem unter dem Einsatz von Natriumzyanid erfolgte und zu wesentlichen Schadstoffbelastungen führte. Der EGMR bejahte unter Verweis auf das Vorsorgeprinzip eine Verletzung von Art. 8 EMRK, obwohl der Beschwerdeführer die Kausalität zwischen der Schadstoffbelastung und der behaupteten Schädigung nicht nachweisen konnte. Eine Analyse der nachfolgenden Entscheidungen veranschaulicht jedoch, dass sich das Vorsorgeprinzip noch nicht als fixer Bestandteil in der Rechtsprechung des EGMR etablieren konnte.
Abschließend wird gezeigt, welchen Beitrag das Vorsorgeprinzip zu der bisher wohl erfolgreichsten Klimaklage „Urgenda“ leistete. Das Vorsorgeprinzip wurde vom niederländischen Höchstgericht in diesem Fall insbesondere herangezogen, um Schutzpflichten aus Art. 2 und Art. 8 EMRK abzuleiten und den staatlichen Ermessenspielraum einzuschränken.
Spätestens seit dem Brand einer Textilfabrik in Karatschi, Pakistan, deren Hauptabnehmer das deutsche Textilunternehmen KiK war, ist die Frage nach der zivilrechtlichen Justiziabilität von Menschenrechtsverletzungen im Ausland auch in der Bundesrepublik angekommen. Parallel hierzu hatte bereits der Einsturz des Rana Plaza, einem Fabrikgebäude in Dhaka, Bangladesch, das zahlreiche Zulieferfirmen der europäischen sowie u.s.-amerikanischen Bekleidungsindustrie beherbergte, traurige Berühmtheit erlangt. Beide Vorfälle hatten in den Industriestaaten des globalen Nordens eine nachhaltige Debatte darüber ausgelöst, welche Verantwortung inländischen Abnehmerunternehmen für die Einhaltung internationaler Menschenrechtsstandards entlang der global angelegten Lieferkette zukommt. An deren vorläufigem Ende steht eine Reihe von Spezialgesetzen, die heimischen Betrieben ausdifferenzierte Sorgfalts- und Überwachungspflichten bezüglich der Arbeitsbedingungen in den – häufig im globalen Süden gelegenen – Produktionsstätten auferlegen.
Als Folge dieses geostrategischen Nord-Süd-Konfliktes wohnt in Deutschland erhobenen Menschenrechtsklagen im Regelfall ein grenzüberscheitendes Moment inne, weshalb sich die Rechtsverfolgung individuell Betroffener mit den Fragen des Internationalen Privatrechts nach der gerichtlichen Zuständigkeit sowie des anwendbaren Sachrechts konfrontiert sieht. Dass ein Verfahren bereits auf dieser Ebene scheitern kann, verdeutlicht auf paradigmatische Weise das eingangs erwähnte Verfahren gegen KiK vor dem LG Dortmund, in welchem das ungünstige pakistanische Verjährungsrecht zur Anwendung gelangte.
Rechtspolitisch wird die Funktion des Rechtsgebietes indes unterschiedlich beurteilt. Während ein Ansatz gleichsam auf materieller Ebene die Entwicklung spezieller Sorgfaltsnormen für Unternehmen in Abnehmerstaaten verfolgt („Verantwortungslösung“), führt eine andere Auffassung den Kern der Problematik nicht auf das – oftmals durchaus funktionale – Produktionslandrecht, sondern vielmehr auf dessen strukturelle Durchsetzungsdefizite zurück („Kognitionslösung“).
Der Beitrag vollzieht die Implikationen beider Ansätze für Zivilprozesse in Deutschland nach. Hierfür wird die Menschenrechtsklage zunächst in das deutsche Verfahrensrecht eingeordnet (I.) bevor die Rolle des Internationalen Privatrechtes erörtert werden kann (II.). Anschließend werden sowohl die Sorgfaltsregime in den Abnehmerstaaten (III.) als auch Rechtsbehelfe in den Produktionsländern am Beispiel Bangladeschs (IV.) in den Blick genommen.
Background
The association between bivariate variables may not necessarily be homogeneous throughout the whole range of the variables. We present a new technique to describe inhomogeneity in the association of bivariate variables.
Methods
We consider the correlation of two normally distributed random variables. The 45° diagonal through the origin of coordinates represents the line on which all points would lie if the two variables completely agreed. If the two variables do not completely agree, the points will scatter on both sides of the diagonal and form a cloud. In case of a high association between the variables, the band width of this cloud will be narrow, in case of a low association, the band width will be wide. The band width directly relates to the magnitude of the correlation coefficient. We then determine the Euclidean distances between the diagonal and each point of the bivariate correlation, and rotate the coordinate system clockwise by 45°. The standard deviation of all Euclidean distances, named “global standard deviation”, reflects the band width of all points along the former diagonal. Calculating moving averages of the standard deviation along the former diagonal results in “locally structured standard deviations” and reflect patterns of “locally structured correlations (LSC)”. LSC highlight inhomogeneity of bivariate correlations. We exemplify this technique by analyzing the association between body mass index (BMI) and hip circumference (HC) in 6313 healthy East German adults aged 18 to 70 years.
Results
The correlation between BMI and HC in healthy adults is not homogeneous. LSC is able to identify regions where the predictive power of the bivariate correlation between BMI and HC increases or decreases, and highlights in our example that slim people have a higher association between BMI and HC than obese people.
Conclusion
Locally structured correlations (LSC) identify regions of higher or lower than average correlation between two normally distributed variables.
Physical activity and exercise are effective approaches in prevention and therapy of multiple diseases. Although the specific characteristics of lengthening contractions have the potential to be beneficial in many clinical conditions, eccentric training is not commonly used in clinical populations with metabolic, orthopaedic, or neurologic conditions. The purpose of this pilot study is to investigate the feasibility, functional benefits, and systemic responses of an eccentric exercise program focused on the trunk and lower extremities in people with low back pain (LBP) and multiple sclerosis (MS). A six-week eccentric training program with three weekly sessions is performed by people with LBP and MS. The program consists of ten exercises addressing strength of the trunk and lower extremities. The study follows a four-group design (N = 12 per group) in two study centers (Israel and Germany): three groups perform the eccentric training program: A) control group (healthy, asymptomatic); B) people with LBP; C) people with MS; group D (people with MS) receives standard care physiotherapy. Baseline measurements are conducted before first training, post-measurement takes place after the last session both comprise blood sampling, self-reported questionnaires, mobility, balance, and strength testing. The feasibility of the eccentric training program will be evaluated using quantitative and qualitative measures related to the study process, compliance and adherence, safety, and overall program assessment. For preliminary assessment of potential intervention effects, surrogate parameters related to mobility, postural control, muscle strength and systemic effects are assessed. The presented study will add knowledge regarding safety, feasibility, and initial effects of eccentric training in people with orthopaedic and neurological conditions. The simple exercises, that are easily modifiable in complexity and intensity, are likely beneficial to other populations. Thus, multiple applications and implementation pathways for the herein presented training program are conceivable.
Recent research suggests that design thinking practices may foster the development of needed capabilities in new digitalised landscapes. However, existing publications represent individual contributions, and we lack a holistic understanding of the value of design thinking in a digital world. No review, to date, has offered a holistic retrospection of this research. In response, in this bibliometric review, we aim to shed light on the intellectual structure of multidisciplinary design thinking literature related to capabilities relevant to the digital world in higher education and business settings, highlight current trends and suggest further studies to advance theoretical and empirical underpinnings. Our study addresses this aim using bibliometric methods—bibliographic coupling and co-word analysis as they are particularly suitable for identifying current trends and future research priorities at the forefront of the research. Overall, bibliometric analyses of the publications dealing with the related topics published in the last 10 years (extracted from the Web of Science database) expose six trends and two possible future research developments highlighting the expanding scope of the design thinking scientific field related to capabilities required for the (more sustainable and human-centric) digital world. Relatedly, design thinking becomes a relevant approach to be included in higher education curricula and human resources training to prepare students and workers for the changing work demands. This paper is well-suited for education and business practitioners seeking to embed design thinking capabilities in their curricula and for design thinking and other scholars wanting to understand the field and possible directions for future research.
Inverted perovskite solar cells still suffer from significant non-radiative recombination losses at the perovskite surface and across the perovskite/C₆₀ interface, limiting the future development of perovskite-based single- and multi-junction photovoltaics. Therefore, more effective inter- or transport layers are urgently required. To tackle these recombination losses, we introduce ortho-carborane as an interlayer material that has a spherical molecular structure and a three-dimensional aromaticity. Based on a variety of experimental techniques, we show that ortho-carborane decorated with phenylamino groups effectively passivates the perovskite surface and essentially eliminates the non-radiative recombination loss across the perovskite/C₆₀ interface with high thermal stability. We further demonstrate the potential of carborane as an electron transport material, facilitating electron extraction while blocking holes from the interface. The resulting inverted perovskite solar cells deliver a power conversion efficiency of over 23% with a low non-radiative voltage loss of 110 mV, and retain >97% of the initial efficiency after 400 h of maximum power point tracking. Overall, the designed carborane based interlayer simultaneously enables passivation, electron-transport and hole-blocking and paves the way toward more efficient and stable perovskite solar cells.
Achilles tendinopathy (AT) is a debilitating injury in athletes, especially for those engaged in repetitive stretch-shortening cycle activities. Clinical risk factors are numerous, but it has been suggested that altered biomechanics might be associated with AT. No systematic review has been conducted investigating these biomechanical alterations in specifically athletic populations. Therefore, the aim of this systematic review was to compare the lower-limb biomechanics of athletes with AT to athletically matched asymptomatic controls. Databases were searched for relevant studies investigating biomechanics during gait activities and other motor tasks such as hopping, isolated strength tasks, and reflex responses. Inclusion criteria for studies were an AT diagnosis in at least one group, cross-sectional or prospective data, at least one outcome comparing biomechanical data between an AT and healthy group, and athletic populations. Studies were excluded if patients had Achilles tendon rupture/surgery, participants reported injuries other than AT, and when only within-subject data was available.. Effect sizes (Cohen's d) with 95% confidence intervals were calculated for relevant outcomes. The initial search yielded 4,442 studies. After screening, twenty studies (775 total participants) were synthesised, reporting on a wide range of biomechanical outcomes. Females were under-represented and patients in the AT group were three years older on average. Biomechanical alterations were identified in some studies during running, hopping, jumping, strength tasks and reflex activity. Equally, several biomechanical variables studied were not associated with AT in included studies, indicating a conflicting picture. Kinematics in AT patients appeared to be altered in the lower limb, potentially indicating a pattern of “medial collapse”. Muscular activity of the calf and hips was different between groups, whereby AT patients exhibited greater calf electromyographic amplitudes despite lower plantar flexor strength. Overall, dynamic maximal strength of the plantar flexors, and isometric strength of the hips might be reduced in the AT group. This systematic review reports on several biomechanical alterations in athletes with AT. With further research, these factors could potentially form treatment targets for clinicians, although clinical approaches should take other contributing health factors into account. The studies included were of low quality, and currently no solid conclusions can be drawn.
Intuitively, strongly constraining contexts should lead to stronger probabilistic representations of sentences in memory. Encountering unexpected words could therefore be expected to trigger costlier shifts in these representations than expected words. However, psycholinguistic measures commonly used to study probabilistic processing, such as the N400 event-related potential (ERP) component, are sensitive to word predictability but not to contextual constraint. Some research suggests that constraint-related processing cost may be measurable via an ERP positivity following the N400, known as the anterior post-N400 positivity (PNP). The PNP is argued to reflect update of a sentence representation and to be distinct from the posterior P600, which reflects conflict detection and reanalysis. However, constraint-related PNP findings are inconsistent. We sought to conceptually replicate Federmeier et al. (2007) and Kuperberg et al. (2020), who observed that the PNP, but not the N400 or the P600, was affected by constraint at unexpected but plausible words. Using a pre-registered design and statistical approach maximising power, we demonstrated a dissociated effect of predictability and constraint: strong evidence for predictability but not constraint in the N400 window, and strong evidence for constraint but not predictability in the later window. However, the constraint effect was consistent with a P600 and not a PNP, suggesting increased conflict between a strong representation and unexpected input rather than greater update of the representation. We conclude that either a simple strong/weak constraint design is not always sufficient to elicit the PNP, or that previous PNP constraint findings could be an artifact of smaller sample size.
Background
Eating in absence of hunger is quite common and often associated with an increased energy intake co-existent with a poorer food choice. Intuitive eating (IE), i.e., eating in accordance with internal hunger and satiety cues, may protect from overeating. IE, however, requires accurate perception and processing of one’s own bodily signals, also referred to as interoceptive sensitivity. Training interoceptive sensitivity might therefore be an effective method to promote IE and prevent overeating. As most studies on eating behavior are conducted in younger adults and close social relationships influence health-related behavior, this study focuses on middle-aged and older couples.
Methods
The present pilot randomized intervention study aims at investigating the feasibility and effectiveness of a 21-day mindfulness-based training program designed to increase interoceptive sensitivity. A total of N = 60 couples participating in the NutriAct Family Study, aged 50–80 years, will be recruited. This randomized-controlled intervention study comprises three measurement points (pre-intervention, post-intervention, 4-week follow-up) and a 21-day training that consists of daily mindfulness-based guided audio exercises (e.g., body scan). A three-arm intervention study design is applied to compare two intervention groups (training together as a couple vs. training alone) with a control group (no training). Each measurement point includes the assessment of self-reported and objective indicators of interoceptive sensitivity (primary outcome), self-reported indicators of intuitive and maladaptive eating (secondary outcomes), and additional variables. A training evaluation applying focus group discussions will be conducted to assess participants’ overall acceptance of the training and its feasibility.
Discussion
By investigating the feasibility and effectiveness of a mindfulness-based training program to increase interoceptive sensitivity, the present study will contribute to a deeper understanding of how to promote healthy eating in older age.
Anomalous-diffusion, the departure of the spreading dynamics of diffusing particles from the traditional law of Brownian-motion, is a signature feature of a large number of complex soft-matter and biological systems. Anomalous-diffusion emerges due to a variety of physical mechanisms, e.g., trapping interactions or the viscoelasticity of the environment. However, sometimes systems dynamics are erroneously claimed to be anomalous, despite the fact that the true motion is Brownian—or vice versa. This ambiguity in establishing whether the dynamics as normal or anomalous can have far-reaching consequences, e.g., in predictions for reaction- or relaxation-laws. Demonstrating that a system exhibits normal- or anomalous-diffusion is highly desirable for a vast host of applications. Here, we present a criterion for anomalous-diffusion based on the method of power-spectral analysis of single trajectories. The robustness of this criterion is studied for trajectories of fractional-Brownian-motion, a ubiquitous stochastic process for the description of anomalous-diffusion, in the presence of two types of measurement errors. In particular, we find that our criterion is very robust for subdiffusion. Various tests on surrogate data in absence or presence of additional positional noise demonstrate the efficacy of this method in practical contexts. Finally, we provide a proof-of-concept based on diverse experiments exhibiting both normal and anomalous-diffusion.
Creative thinking is an indispensable cognitive skill that is becoming increasingly important. In the present research, we tested the impact of games on creativity and emotions in a between-subject online experiment with four conditions (N = 658). (1) participants played a simple puzzle game that allowed many solutions (priming divergent thinking); (2) participants played a short game that required one fitting solution (priming convergent thinking); (3) participants performed mental arithmetic; (4) passive control condition. Results show that divergent and convergent creativity were higher after playing games and lower after mental arithmetic. Positive emotions did not function as a mediator, even though they were also heightened after playing the games and lower after mental arithmetic. However, contrary to previous research, we found no direct effect of emotions, creative self-efficacy, and growth- vs. fixed on creative performance. We discuss practical implications for digital learning and application settings.
Desperados at Sea
(2023)
Pirates are fortune-seeking fighters at sea. Their exploits fire the imaginations of their victims and admirers, drawing a veil over individuals who rarely bear a real name and pursue their adventurous occupations as buccaneers, filibusters, freebooters, privateers, pirates, or corsairs. Piracy, corsairing, and contraband trade were epidemic among the Egyptians and the Phoenicians, the Greeks and the Vikings, the Spaniards and the Ottomans, the Muslims, and the Christians. And the Jews.
Jacob Brandon Maduro’s Memoirs and Related Observations (Havana, 1953) speak to the lasting yet malleable legacy of Jewish Caribbean/Atlantic mercantile communities that defined early modern settlement in the Americas. A close reading of the Memoirs, alongside relevant archival records and community narratives, lends new perspectives to scholarship on Port Jewries and the Atlantic Diaspora. Specifically concerned with Jacob’s adoption of such leading intellectual and political tropes as the Monroe doctrine, José Martí’s Nuestra America, and a Zionism that evolved from an ideology to a reality, the Memoirs reveal a narrative at once defined by the tremendous upheavals of the first half of the 20th century, and an enduring sense of Jewish diasporic peoplehood defined through a Port Jew paradigm whereby the preservation of Jewish ethnicity is understood as synonymous with the championing of modernity.
“Creating a Maritime Future”
(2023)
This article explores the importance of the port city of Hamburg in the evolving discourses on the creation of a maritime future, a vision which became influential in the 1930s, 1940s and 1950s. While some Jewish representatives in the city aimed at preserving and intertwining Hanseatic and Jewish traditions in order to secure a Jewish presence in the port city under the pressure of the Nazi regime and thereafter, others wanted to create new emigration opportunities, especially to Mandatory Palestine, and create a Jewish maritime future in Eretz Israel. Different Zionist organizations supported the newly evolving maritime ideas, such as the “conquest of the sea”, and promoted the image of a Jewish seafaring nation. Despite the difficulties in the 1940s, these concepts gained influence post-1945 and led to the foundation of the fishery kibbutz “Zerubavel” in Blankenese/Hamburg. However, the idea of a Hanseatic Jewish future also remained influential and illustrates how differently a “Jewish maritime future” was imagined and used to link past, present and future.
Mothers of Seafaring
(2023)
The article aims to trace the contribution of Jewish women in the Yishuv’s maritime history. Taking the example of Henrietta Diamond, a founding member and chairperson of the Zebulun Seafaring Society, the article seeks to explore the representation and role of women in a growing Jewish maritime domain from the 1930s to the 1950s. It examines Zionist narratives on the ‘New Jew’ and the Jewish body and studies their relevance for the emerging field of maritime activities in the Yishuv. By contextualizing the work and depiction of Henrietta Diamond, the article sheds new light on the gendered notions that underlay the emergence of the Jewish maritime domain and illustrates the patterns of inclusion and exclusion in it.
The birth of the Yishuv’s national shipping company, ZIM was preceded by private enterprise; the sea had not traditionally been a focus of the Zionist movement. In the 1930s, a five-year span of private commercial shipping saw three companies in the Jewish community in Palestine – Palestine Shipping Company, Palestine Maritime Lloyd, and Atid – before shipping was cut short by the outbreak of the Second World War. Despite their brief lifespans and their negligible contribution to general shipping, these companies constituted an important milestone. Their existence helped shift the Yishuv leadership’s attitudes about shipping’s importance for the community and the need for it to be supported by national institutions.
“Israel am Meere”
(2023)
For Jews in Germany, the period following the Nazis’ rise to power in January 1933 was a period of decision-making on many levels: How should they respond to the persecution? If they decided to emigrate, many more decisions had to be made: How does one leave a country, and where should one go? A key moment in the process and in the cultural practice of emigration is the beginning of the sea voyage – when the need for departure and the hope for a new arrival jointly create a period of liminality. Looking at reports from sea voyages of exploration and emigration from the 1930s, this contribution discusses the question whether, and in what ways, such reflections can be read in the context of religious experiences and in the search for Jewish identities in times of turmoil.
‚Maise Jeschurun‘
(2023)
Abgelegte Musik
(2023)
Schutz und Schaden
(2023)
Einleitung
(2023)
Nutrition, size, and tempo
(2023)
Nutrition is a prerequisite, but not a regulator of growth. Growth is defined as increase in size over time. The understanding of growth includes an understanding of the binary concept of physical time and individual tempo. Excess food causes tempo acceleration. Food restriction delays tempo. Tempo reflects the pace of life. It is a dynamic physical response to a broad spectrum of social, economic, political, and emotional (SEPE) factors and can affect life expectancy. Variations in tempo create distortions of the z-score patterns of height and weight. Illness or intermediate food shortage lead to intermediate halts in development and create short dips in the z-score patterns. Children who develop throughout life at delayed pace usually run at lower z-scores for height and weight, and show a characteristic adolescent trough; children who develop throughout life at faster than average pace usually run at higher z-scores and show a characteristic adolescent peak in their z-score patterns. During adolescence, almost half of the height variance is due to tempo variation. There is not one tempo for the whole body. Different organ systems grow and mature at different pace.
What does stunting tell us?
(2023)
Stunting is commonly linked with undernutrition. Yet, already after World War I, German pediatricians questioned this link and stated that no association exists between nutrition and height. Recent analyses within different populations of Low- and middle-income countries with high rates of stunted children failed to support the assumption that stunted children have a low BMI and skinfold sickness as signs of severe caloric deficiency. So, stunting is not a synonym of malnutrition. Parental education level has a positive influence on body height in stunted populations, e.g., in India and in Indonesia. Socially disadvantaged children tend to be shorter and lighter than children from affluent families.
Humans are social mammals; they regulate growth similar to other social mammals. Also in humans, body height is strongly associated with the position within the social hierarchy, reflecting the personal and group-specific social, economic, political, and emotional environment. These non-nutritional impact factors on growth are summarized by the concept of SEPE (Social-Economic-Political-Emotional) factors. SEPE reflects on prestige, dominance-subordination, social identity, and ego motivation of individuals and social groups.
Background
Maximal isokinetic strength ratios of joint flexors and extensors are important parameters to indicate the level of muscular balance at the joint. Further, in combat sports athletes, upper and lower limb muscle strength is affected by the type of sport. Thus, this study aimed to examine the differences in maximal isokinetic strength of the flexors and extensors and the corresponding flexor–extensor strength ratios of the elbows and knees in combat sports athletes.
Method
Forty male participants (age = 22.3 ± 2.5 years) from four different combat sports (amateur boxing, taekwondo, karate, and judo; n = 10 per sport) were tested for eccentric peak torque of the elbow/knee flexors (EF/KF) and concentric peak torque of the elbow/knee extensors (EE/KE) at three different angular velocities (60, 120, and 180°/s) on the dominant and non-dominant side using an isokinetic device.
Results
Analyses revealed significant, large-sized group × velocity × limb interactions for EF, EE, and EF–EE ratio, KF, KE, and KF–KE ratio (p ≤ 0.03; 0.91 ≤ d ≤ 1.75). Post-hoc analyses indicated that amateur boxers displayed the largest EE strength values on the non-dominant side at ≤ 120°/s and the dominant side at ≥ 120°/s (p < 0.03; 1.21 ≤ d ≤ 1.59). The largest EF–EE strength ratios were observed on amateur boxers’ and judokas’ non-dominant side at ≥ 120°/s (p < 0.04; 1.36 ≤ d ≤ 2.44). Further, we found lower KF–KE strength measures in karate (p < 0.04; 1.12 ≤ d ≤ 6.22) and judo athletes (p ≤ 0.03; 1.60 ≤ d ≤ 5.31) particularly on the non-dominant side.
Conclusions
The present findings indicated combat sport-specific differences in maximal isokinetic strength measures of EF, EE, KF, and KE particularly in favor of amateur boxers on the non-dominant side.
This study examined the spoken narrative skills of a group of bilingual Mandarin–English speaking 3–6-year-olds (N = 25) in Australia, using a remote online story-retell task. Bilingual preschoolers are an understudied population, especially those who are speaking typologically distinct languages such as Mandarin and English which have fewer structural overlaps compared to language pairs that are typologically closer, reducing cross-linguistic positive transfer. We examined these preschoolers’ spoken narrative skills as measured by macrostructures (the global organization of a story) and microstructures (linguistic structures, e.g., total number of utterances, nouns, verbs, phrases, and modifiers) across and within each language, and how various factors such as age and language experiences contribute to individual variability. The results indicate that our bilingual preschoolers acquired spoken narrative skills similarly across their two languages, i.e., showing similar patterns of productivity for macrostructure and microstructure elements in both of their two languages. While chronological age was positively correlated with macrostructures in both languages (showing developmental effects), there were no significant correlations between measures of language experiences and the measures of spoken narrative skills (no effects for language input/output). The findings suggest that although these preschoolers acquire two typologically diverse languages in different learning environments, Mandarin at home with highly educated parents, and English at preschool, they displayed similar levels of oral narrative skills as far as these macro−/micro-structure measures are concerned. This study provides further evidence for the feasibility of remote online assessment of preschoolers’ narrative skills.
Objective: There is a lack of brief rating scales for the reliable assessment of psychotherapeutic skills, which do not require intensive rater training and/or a high level of expertise. Thus, the objective is to validate a 14-item version of the Clinical Communication Skills Scale (CCSS-S).
Methods: Using a sample of N = 690 video-based ratings of role-plays with simulated patients, we calculated a confirmatory factor analysis and an exploratory structural equation modeling (ESEM), assessed convergent validities, determined inter-rater reliabilities and compared these with those who were either psychology students, advanced psychotherapy trainees, or experts.
Results: Correlations with other competence rating scales were high (rs > 0.86–0.89). The intraclass correlations ranged between moderate and good [ICC(2,2) = 0.65–0.80], with student raters yielding the lowest scores. The one-factor model only marginally replicated the data, but the internal consistencies were excellent (α = 0.91–95). The ESEM yielded a two-factor solution (Collaboration and Structuring and Exploration Skills).
Conclusion: The CCSS-S is a brief and valid rating scale that reliably assesses basic communication skills, which is particularly useful for psychotherapy training using standardized role-plays. To ensure good inter-rater reliabilities, it is still advisable to employ raters with at least some clinical experience. Future studies should further investigate the one- or two-factor structure of the instrument.
For life-long learning, an effective learning strategy repertoire is particularly important during acquisition of knowledge in lower secondary school—an educational level characterized with transition into more autonomous learning environments with increased complex academic demands. Using latent profile analysis, we explored the occurrence of different secondary school learner profiles depending on their various combinations of cognitive and metacognitive learning strategy use, as well as their differences in perceived autonomy support, intrinsic motivation, and gender. Data were collected from 576 ninth grade students in Uganda using self-report questionnaires. Four learner profiles were identified: competent strategy user, struggling user, surface-level learner, and deep-level learner profiles. Gender differences were noted in students’ use of elaboration and organization strategies to learn Physics, in favor of girls. In terms of profile memberships, significant differences in gender, intrinsic motivation and perceived autonomy support were also noted. Girls were 2.4–2.7 times more likely than boys to be members of the competent strategy user and surface-level learner profiles. Additionally, higher levels of intrinsic motivation predicted an increased likelihood membership into the deep-level learner profile, while higher levels of perceived teacher autonomy predicted an increased likelihood membership into the competent strategy user profile as compared to other profiles. Further, implications of the findings were discussed.
There is an ongoing debate about how to test and operationalize self-control. This limited understanding is in large part due to a variety of different tests and measures used to assess self-control, as well as the lack of empirical studies examining the temporal dynamics during the exertion of self-control. In order to track changes that occur over the course of exposure to a self-control task, we investigate and compare behavioral, subjective, and physiological indicators during the exertion of self-control. Participants completed both a task requiring inhibitory control (Go/No-Go task) and a control task (two-choice task). Behavioral performance and pupil size were measured during the tasks. Subjective vitality was measured before and after the tasks. While pupil size and subjective vitality showed similar trajectories in the two tasks, behavioral performance decreased in the inhibitory control-demanding task, but not in the control task. However, behavioral, subjective, and physiological measures were not significantly correlated. These results suggest that there is a disconnect between different measures of self-control with high intra- and interindividual variability. Theoretical and methodological implications for self-control theory and future empirical work are discussed.
Background
Communicating a diagnosis is highly important, yet complex, especially in the context of cancer and mental disorders. The aim was to explore the communication style of an oncologist vs. psychotherapist in an online study.
Methods
Patients (N = 136: 65 cancer, 71 depression) were randomly assigned to watch a standardized video vignette with one of two communication styles (empathic vs. unempathic). Outcome measures of affectivity, information recall, communication skills, empathy and trust were applied.
Results
Regardless of diagnosis, empathic communication was associated with the perception of a significantly more empathic (p < 0.001, η2partial = 0.08) and trustworthy practitioner (p = 0.014, η2partial = 0.04) with better communication skills (p = 0.013, η2partial = 0.05). Cancer patients reported a larger decrease in positive affect (p < 0.001, η2partial = 0.15) and a larger increase in negative affect (p < 0.001, η2partial = 0.14) from pre- to post-video than depressive patients. Highly relevant information was recalled better in both groups (p < 0.001, d = 0.61–1.06).
Conclusions
The results highlight the importance of empathy while communicating both a diagnosis of cancer and a mental disorder. Further research should focus on the communication of a mental disorder in association with cancer.
Basic psychological needs theory postulates that a social environment that satisfies individuals’ three basic psychological needs of autonomy, competence, and relatedness leads to optimal growth and well-being. On the other hand, the frustration of these needs is associated with ill-being and depressive symptoms foremost investigated in non-clinical samples; yet, there is a paucity of research on need frustration in clinical samples. Survey data were compared between adult individuals with major depressive disorder (MDD; n = 115; 48.69% female; 38.46 years, SD = 10.46) with those of a non-depressed comparison sample (n = 201; 53.23% female; 30.16 years, SD = 12.81). Need profiles were examined with a linear mixed model (LMM). Individuals with depression reported higher levels of frustration and lower levels of satisfaction in relation to the three basic psychological needs when compared to non-depressed adults. The difference between depressed and non-depressed groups was significantly larger for frustration than satisfaction regarding the needs for relatedness and competence. LMM correlation parameters confirmed the expected positive correlation between the three needs. This is the first study showing substantial differences in need-based experiences between depressed and non-depressed adults. The results confirm basic assumptions of the self-determination theory and have preliminary implications in tailoring therapy for depression.
Dementia as one of the most prevalent diseases urges for a better understanding of the central mechanisms responsible for clinical symptoms, and necessitates improvement of actual diagnostic capabilities. The brainstem nucleus locus coeruleus (LC) is a promising target for early diagnosis because of its early structural alterations and its relationship to the functional disturbances in the patients. In this study, we applied our improved method of localisation-based LC resting-state fMRI to investigate the differences in central sensory signal processing when comparing functional connectivity (fc) of a patient group with mild cognitive impairment (MCI, n = 28) and an age-matched healthy control group (n = 29). MCI and control participants could be differentiated in their Mini-Mental-State-Examination (MMSE) scores (p < .001) and LC intensity ratio (p = .010). In the fMRI, LC fc to anterior cingulate cortex (FDR p < .001) and left anterior insula (FDR p = .012) was elevated, and LC fc to right temporoparietal junction (rTPJ, FDR p = .012) and posterior cingulate cortex (PCC, FDR p = .021) was decreased in the patient group. Importantly, LC to rTPJ connectivity was also positively correlated to MMSE scores in MCI patients (p = .017). Furthermore, we found a hyperactivation of the left-insula salience network in the MCI patients. Our results and our proposed disease model shed new light on the functional pathogenesis of MCI by directing to attentional network disturbances, which could aid new therapeutic strategies and provide a marker for diagnosis and prediction of disease progression.
Privacy regulations and the physical distribution of heterogeneous data are often primary concerns for the development of deep learning models in a medical context. This paper evaluates the feasibility of differentially private federated learning for chest X-ray classification as a defense against data privacy attacks. To the best of our knowledge, we are the first to directly compare the impact of differentially private training on two different neural network architectures, DenseNet121 and ResNet50. Extending the federated learning environments previously analyzed in terms of privacy, we simulated a heterogeneous and imbalanced federated setting by distributing images from the public CheXpert and Mendeley chest X-ray datasets unevenly among 36 clients. Both non-private baseline models achieved an area under the receiver operating characteristic curve (AUC) of 0.940.94 on the binary classification task of detecting the presence of a medical finding. We demonstrate that both model architectures are vulnerable to privacy violation by applying image reconstruction attacks to local model updates from individual clients. The attack was particularly successful during later training stages. To mitigate the risk of a privacy breach, we integrated Rényi differential privacy with a Gaussian noise mechanism into local model training. We evaluate model performance and attack vulnerability for privacy budgets ε∈{1,3,6,10}�∈{1,3,6,10}. The DenseNet121 achieved the best utility-privacy trade-off with an AUC of 0.940.94 for ε=6�=6. Model performance deteriorated slightly for individual clients compared to the non-private baseline. The ResNet50 only reached an AUC of 0.760.76 in the same privacy setting. Its performance was inferior to that of the DenseNet121 for all considered privacy constraints, suggesting that the DenseNet121 architecture is more robust to differentially private training.
In recent years digital technologies have become a major means for providing health-related services and this trend was strongly reinforced by the current Coronavirus disease 2019 (COVID-19) pandemic. As it is well-known that regular physical activity has positive effects on individual physical and mental health and thus is an important prerequisite for healthy aging, digital technologies are also increasingly used to promote unstructured and structured forms of physical activity. However, in the course of this development, several terms (e.g., Digital Health, Electronic Health, Mobile Health, Telehealth, Telemedicine, and Telerehabilitation) have been introduced to refer to the application of digital technologies to provide health-related services such as physical interventions. Unfortunately, the above-mentioned terms are often used in several different ways, but also relatively interchangeably. Given that ambiguous terminology is a major source of difficulty in scientific communication which can impede the progress of theoretical and empirical research, this article aims to make the reader aware of the subtle differences between the relevant terms which are applied at the intersection of physical activity and Digital Health and to provide state-of-art definitions for them.
Numerical magnitude information is assumed to be spatially represented in the form of a mental number line defined with respect to a body-centred, egocentric frame of reference. In this context, spatial language skills such as mastery of verbal descriptions of spatial position (e.g., in front of, behind, to the right/left) have been proposed to be relevant for grasping spatial relations between numerical magnitudes on the mental number line. We examined 4- to 5-year-old’s spatial language skills in tasks that allow responses in egocentric and allocentric frames of reference, as well as their relative understanding of numerical magnitude (assessed by a number word comparison task). In addition, we evaluated influences of children’s absolute understanding of numerical magnitude assessed by their number word comprehension (montring different numbers using their fingers) and of their knowledge on numerical sequences (determining predecessors and successors as well as identifying missing dice patterns of a series). Results indicated that when considering responses that corresponded to the egocentric perspective, children’s spatial language was associated significantly with their relative numerical magnitude understanding, even after controlling for covariates, such as children’s SES, mental rotation skills, and also absolute magnitude understanding or knowledge on numerical sequences. This suggests that the use of egocentric reference frames in spatial language may facilitate spatial representation of numbers along a mental number line and thus seem important for preschoolers’ relative understanding of numerical magnitude.
In intervention research, single-case experimental designs are an important way to gain insights into the causes of individual changes that yield high internal validity. They are commonly applied to examine the effectiveness of classroom-based interventions to reduce problem behavior in schools. At the same time, there is no consensus on good design characteristics of single-case experimental designs when dealing with behavioral problems in schools. Moreover, specific challenges arise concerning appropriate approaches to analyzing behavioral data. Our study addresses the interplay between the test power of piecewise regression analysis and important design specifications of single-case research designs. Here, we focus on the influence of the following specifications of single-case research designs: number of measurement times, the initial frequency of the behavior, intervention effect, and data trend. We conducted a Monte-Carlo study. First, simulated datasets were created with specific design conditions based on reviews of published single-case intervention studies. Following, data were analyzed using piecewise Poisson-regression models, and the influence of specific design specifications on the test power was investigated. Our results indicate that piecewise regressions have a high potential of adequately identifying the effects of interventions for single-case studies. At the same time, test power is strongly related to the specific design specifications of the single-case study: Few measurement times, especially in phase A, and low initial frequencies of the behavior make it impossible to detect even large intervention effects. Research designs with a high number of measurement times show robust power. The insights gained are highly relevant for researchers in the field, as decisions during the early stage of conceptualizing and planning single-case experimental design studies may impact the chance to identify an existing intervention effect during the research process correctly.
The aim of this review was to describe and summarize the scientific literature on programming parameters related to jump or plyometric training in male and female soccer players of different ages and fitness levels. A literature search was conducted in the electronic databases PubMed, Web of Science and Scopus using keywords related to the main topic of this study (e.g., “ballistic” and “plyometric”). According to the PICOS framework, the population for the review was restricted to soccer players, involved in jump or plyometric training. Among 7556 identified studies, 90 were eligible for inclusion. Only 12 studies were found for females. Most studies (n = 52) were conducted with youth male players. Moreover, only 35 studies determined the effectiveness of a given jump training programming factor. Based on the limited available research, it seems that a dose of 7 weeks (1–2 sessions per week), with ~80 jumps (specific of combined types) per session, using near-maximal or maximal intensity, with adequate recovery between repetitions (<15 s), sets (≥30 s) and sessions (≥24–48 h), using progressive overload and taper strategies, using appropriate surfaces (e.g., grass), and applied in a well-rested state, when combined with other training methods, would increase the outcome of effective and safe plyometric-jump training interventions aimed at improving soccer players physical fitness. In conclusion, jump training is an effective and easy-to-administer training approach for youth, adult, male and female soccer players. However, optimal programming for plyometric-jump training in soccer is yet to be determined in future research.
Quantifying neurological disorders from voice is a rapidly growing field of research and holds promise for unobtrusive and large-scale disorder monitoring. The data recording setup and data analysis pipelines are both crucial aspects to effectively obtain relevant information from participants. Therefore, we performed a systematic review to provide a high-level overview of practices across various neurological disorders and highlight emerging trends. PRISMA-based literature searches were conducted through PubMed, Web of Science, and IEEE Xplore to identify publications in which original (i.e., newly recorded) datasets were collected. Disorders of interest were psychiatric as well as neurodegenerative disorders, such as bipolar disorder, depression, and stress, as well as amyotrophic lateral sclerosis amyotrophic lateral sclerosis, Alzheimer's, and Parkinson's disease, and speech impairments (aphasia, dysarthria, and dysphonia). Of the 43 retrieved studies, Parkinson's disease is represented most prominently with 19 discovered datasets. Free speech and read speech tasks are most commonly used across disorders. Besides popular feature extraction toolkits, many studies utilise custom-built feature sets. Correlations of acoustic features with psychiatric and neurodegenerative disorders are presented. In terms of analysis, statistical analysis for significance of individual features is commonly used, as well as predictive modeling approaches, especially with support vector machines and a small number of artificial neural networks. An emerging trend and recommendation for future studies is to collect data in everyday life to facilitate longitudinal data collection and to capture the behavior of participants more naturally. Another emerging trend is to record additional modalities to voice, which can potentially increase analytical performance.
Sulfur is an important element that is incorporated into many biomolecules in humans. The incorporation and transfer of sulfur into biomolecules is, however, facilitated by a series of different sulfurtransferases. Among these sulfurtransferases is the human mercaptopyruvate sulfurtransferase (MPST) also designated as tRNA thiouridine modification protein (TUM1). The role of the human TUM1 protein has been suggested in a wide range of physiological processes in the cell among which are but not limited to involvement in Molybdenum cofactor (Moco) biosynthesis, cytosolic tRNA thiolation and generation of H2S as signaling molecule both in mitochondria and the cytosol. Previous interaction studies showed that TUM1 interacts with the L-cysteine desulfurase NFS1 and the Molybdenum cofactor biosynthesis protein 3 (MOCS3). Here, we show the roles of TUM1 in human cells using CRISPR/Cas9 genetically modified Human Embryonic Kidney cells. Here, we show that TUM1 is involved in the sulfur transfer for Molybdenum cofactor synthesis and tRNA thiomodification by spectrophotometric measurement of the activity of sulfite oxidase and liquid chromatography quantification of the level of sulfur-modified tRNA. Further, we show that TUM1 has a role in hydrogen sulfide production and cellular bioenergetics.
In late summer, migratory bats of the temperate zone face the challenge of accomplishing two energy-demanding tasks almost at the same time: migration and mating. Both require information and involve search efforts, such as localizing prey or finding potential mates. In non-migrating bat species, playback studies showed that listening to vocalizations of other bats, both con-and heterospecifics, may help a recipient bat to find foraging patches and mating sites. However, we are still unaware of the degree to which migrating bats depend on con-or heterospecific vocalizations for identifying potential feeding or mating opportunities during nightly transit flights. Here, we investigated the vocal responses of Nathusius’ pipistrelle bats, Pipistrellus nathusii, to simulated feeding and courtship aggregations at a coastal migration corridor. We presented migrating bats either feeding buzzes or courtship calls of their own or a heterospecific migratory species, the common noctule, Nyctalus noctula. We expected that during migratory transit flights, simulated feeding opportunities would be particularly attractive to bats, as well as simulated mating opportunities which may indicate suitable roosts for a stopover. However, we found that when compared to the natural silence of both pre-and post-playback phases, bats called indifferently during the playback of conspecific feeding sounds, whereas P. nathusii echolocation call activity increased during simulated feeding of N. noctula. In contrast, the call activity of P. nathusii decreased during the playback of conspecific courtship calls, while no response could be detected when heterospecific call types were broadcasted. Our results suggest that while on migratory transits, P. nathusii circumnavigate conspecific mating aggregations, possibly to save time or to reduce the risks associated with social interactions where aggression due to territoriality might be expected. This avoidance behavior could be a result of optimization strategies by P. nathusii when performing long-distance migratory flights, and it could also explain the lack of a response to simulated conspecific feeding. However, the observed increase of activity in response to simulated feeding of N. noctula, suggests that P. nathusii individuals may be eavesdropping on other aerial hawking insectivorous species during migration, especially if these occupy a slightly different foraging niche.
Genetic divergence and the frequency of hybridization are central for defining species delimitations, especially among cryptic species where morphological differences are merely absent. Rotifers are known for their high cryptic diversity and therefore are ideal model organisms to investigate such patterns. Here, we used the recently resolved Brachionus calyciflorus species complex to investigate whether previously observed between species differences in thermotolerance and gene expression are also reflected in their genomic footprint. We identified a Heat Shock Protein gene (HSP 40 kDa) which exhibits cross species pronounced sequence variation. This gene exhibits species-specific fixed sites, alleles, and sites putatively under positive selection. These sites are located in protein binding regions involved in chaperoning and may therefore reflect adaptive diversification. By comparing three genetic markers (ITS, COI, HSP 40 kDa), we revealed hybridization events between the cryptic species. The low frequency of introgressive haplotypes/alleles suggest a tight, but not fully impermeable boundary between the cryptic species.
This study examines the access to healthcare for children and adolescents with three common chronic diseases (type-1 diabetes (T1D), obesity, or juvenile idiopathic arthritis (JIA)) within the 4th (Delta), 5th (Omicron), and beginning of the 6th (Omicron) wave (June 2021 until July 2022) of the COVID-19 pandemic in Germany in a cross-sectional study using three national patient registries. A paper-and-pencil questionnaire was given to parents of pediatric patients (<21 years) during the routine check-ups. The questionnaire contains self-constructed items assessing the frequency of healthcare appointments and cancellations, remote healthcare, and satisfaction with healthcare. In total, 905 parents participated in the T1D-sample, 175 in the obesity-sample, and 786 in the JIA-sample. In general, satisfaction with healthcare (scale: 0–10; 10 reflecting the highest satisfaction) was quite high (median values: T1D 10, JIA 10, obesity 8.5). The proportion of children and adolescents with canceled appointments was relatively small (T1D 14.1%, JIA 11.1%, obesity 20%), with a median of 1 missed appointment, respectively. Only a few parents (T1D 8.6%; obesity 13.1%; JIA 5%) reported obstacles regarding health services during the pandemic. To conclude, it seems that access to healthcare was largely preserved for children and adolescents with chronic health conditions during the COVID-19 pandemic in Germany.
Research within the framework of Basic Psychological Need Theory (BPNT) finds strong associations between basic need frustration and depressive symptoms. This study examined the role of rumination as an underlying mechanism in the association between basic psychological need frustration and depressive symptoms. A cross-sectional sample of N = 221 adults (55.2% female, mean age = 27.95, range = 18–62, SD = 10.51) completed measures assessing their level of basic psychological need frustration, rumination, and depressive symptoms. Correlational analyses and multiple mediation models were conducted. Brooding partially mediated the relation between need frustration and depressive symptoms. BPNT and Response Styles Theory are compatible and can further advance knowledge about depression vulnerabilities.
In numerical processing, the functional role of Spatial-Numerical Associations (SNAs, such as the association of smaller numbers with left space and larger numbers with right space, the Mental Number Line hypothesis) is debated. Most studies demonstrate SNAs with lateralized responses, and there is little evidence that SNAs appear when no response is required. We recorded passive holding grip forces in no-go trials during number processing. In Experiment 1, participants performed a surface numerical decision task (“Is it a number or a letter?”). In Experiment 2, we used a deeper semantic task (“Is this number larger or smaller than five?”). Despite instruction to keep their grip force constant, participants' spontaneous grip force changed in both experiments: Smaller numbers led to larger force increase in the left than in the right hand in the numerical decision task (500–700 ms after stimulus onset). In the semantic task, smaller numbers again led to larger force increase in the left hand, and larger numbers increased the right-hand holding force. This effect appeared earlier (180 ms) and lasted longer (until 580 ms after stimulus onset). This is the first demonstration of SNAs with passive holding force. Our result suggests that (1) explicit motor response is not a prerequisite for SNAs to appear, and (2) the timing and strength of SNAs are task-dependent. (216 words).
Background
Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) has received tremendous attention as a potential neuromodulator of cognitive and affective functions, which likely exerts its effects via activation of the locus coeruleus-noradrenaline (LC-NA) system. Reliable effects of taVNS on markers of LC-NA system activity, however, have not been demonstrated yet.
Methods
The aim of the present study was to overcome previous limitations by pooling raw data from a large sample of ten taVNS studies (371 healthy participants) that collected salivary alpha-amylase (sAA) as a potential marker of central NA release.
Results
While a meta-analytic approach using summary statistics did not yield any significant effects, linear mixed model analyses showed that afferent stimulation of the vagus nerve via taVNS increased sAA levels compared to sham stimulation (b = 0.16, SE = 0.05, p = 0.001). When considering potential confounders of sAA, we further replicated previous findings on the diurnal trajectory of sAA activity.
Conclusion(s)
Vagal activation via taVNS increases sAA release compared to sham stimulation, which likely substantiates the assumption that taVNS triggers NA release. Moreover, our results highlight the benefits of data pooling and data sharing in order to allow stronger conclusions in research.
Flood risk management in Germany follows an integrative approach in which both private households and businesses can make an important contribution to reducing flood damage by implementing property-level adaptation measures. While the flood adaptation behavior of private households has already been widely researched, comparatively less attention has been paid to the adaptation strategies of businesses. However, their ability to cope with flood risk plays an important role in the social and economic development of a flood-prone region. Therefore, using quantitative survey data, this study aims to identify different strategies and adaptation drivers of 557 businesses damaged by a riverine flood in 2013 and 104 businesses damaged by pluvial or flash floods between 2014 and 2017. Our results indicate that a low perceived self-efficacy may be an important factor that can reduce the motivation of businesses to adapt to flood risk. Furthermore, property-owners tended to act more proactively than tenants. In addition, high experience with previous flood events and low perceived response costs could strengthen proactive adaptation behavior. These findings should be considered in business-tailored risk communication.
Large-scale databases that report the inhibitory capacities of many combinations of candidate drug compounds and cultivated cancer cell lines have driven the development of preclinical drug-sensitivity models based on machine learning. However, cultivated cell lines have devolved from human cancer cells over years or even decades under selective pressure in culture conditions. Moreover, models that have been trained on in vitro data cannot account for interactions with other types of cells. Drug-response data that are based on patient-derived cell cultures, xenografts, and organoids, on the other hand, are not available in the quantities that are needed to train high-capacity machine-learning models. We found that pre-training deep neural network models of drug sensitivity on in vitro drug-sensitivity databases before fine-tuning the model parameters on patient-derived data improves the models’ accuracy and improves the biological plausibility of the features, compared to training only on patient-derived data. From our experiments, we can conclude that pre-trained models outperform models that have been trained on the target domains in the vast majority of cases.
Background
Animal personality has emerged as a key concept in behavioral ecology. While many studies have demonstrated the influence of personality traits on behavioral patterns, its quantification, especially in wild animal populations, remains a challenge. Only a few studies have established a link between personality and recurring movements within home ranges, although these small-scale movements are of key importance for identifying ecological interactions and forming individual niches. In this regard, differences in space use among individuals might reflect different exploration styles between behavioral types along the shy-bold continuum.
Methods
We assessed among-individual differences in behavior in the European hare (Lepus europaeus), a characteristic mammalian herbivore in agricultural landscapes using a standardized box emergence test for captive and wild hares. We determined an individuals’ degree of boldness by measuring the latencies of behavioral responses in repeated emergence tests in captivity. During capture events of wild hares, we conducted a single emergence test and recorded behavioral responses proven to be stable over time in captive hares. Applying repeated novel environment tests in a near-natural enclosure, we further quantified aspects of exploration and activity in captive hares. Finally, we investigated whether and how this among-individual behavioral variation is related to general activity and space use in a wild hare population. Wild and captive hares were treated similarly and GPS-collared with internal accelerometers prior to release to the wild or the outdoor enclosure, respectively. General activity was quantified as overall dynamic body acceleration (ODBA) obtained from accelerometers. Finally, we tested whether boldness explained variation in (i) ODBA in both settings and (ii) variation in home ranges and core areas across different time scales of GPS-collared hares in a wild population.
Results
We found three behavioral responses to be consistent over time in captive hares. ODBA was positively related to boldness (i.e., short latencies to make first contact with the new environment) in both captive and wild hares. Space use in wild hares also varied with boldness, with shy individuals having smaller core areas and larger home ranges than bold conspecifics (yet in some of the parameter space, this association was just marginally significant).
Conclusions
Against our prediction, shy individuals occupied relatively large home ranges but with small core areas. We suggest that this space use pattern is due to them avoiding risky, and energy-demanding competition for valuable resources. Carefully validated, activity measurements (ODBA) from accelerometers provide a valuable tool to quantify aspects of animal personality along the shy-bold continuum remotely. Without directly observing—and possibly disturbing—focal individuals, this approach allows measuring variability in animal personality, especially in species that are difficult to assess with experiments. Considering that accelerometers are often already built into GPS units, we recommend activating them at least during the initial days of tracking to estimate individual variation in general activity and, if possible, match them with a simple novelty experiment. Furthermore, information on individual behavioral types will help to facilitate mechanistic understanding of processes that drive spatial and ecological dynamics in heterogeneous landscapes.
Glaciated high-alpine areas are fundamentally altered by climate change, with well-known implications for hydrology, e.g., due to glacier retreat, longer snow-free periods, and more frequent and intense summer rainstorms. While knowledge on how these hydrological changes will propagate to suspended sediment dynamics is still scarce, it is needed to inform mitigation and adaptation strategies. To understand the processes and source areas most relevant to sediment dynamics, we analyzed discharge and sediment dynamics in high temporal resolution as well as their patterns on several spatial scales, which to date few studies have done.
We used a nested catchment setup in the Upper Ötztal in Tyrol, Austria, where high-resolution (15 min) time series of discharge and suspended sediment concentrations are available for up to 15 years (2006–2020). The catchments of the gauges in Vent, Sölden and Tumpen range from 100 to almost 800 km2 with 10 % to 30 % glacier cover and span an elevation range of 930 to 3772 m a.s.l. We analyzed discharge and suspended sediment yields (SSY), their distribution in space, their seasonality and spatial differences therein, and the relative importance of short-term events. We complemented our analysis by linking the observations to satellite-based snow cover maps, glacier inventories, mass balances and precipitation data.
Our results indicate that the areas above 2500 m a.s.l., characterized by glacier tongues and the most recently deglaciated areas, are crucial for sediment generation in all sub-catchments. This notion is supported by the synchronous spring onset of sediment export at the three gauges, which coincides with snowmelt above 2500 m but lags behind spring discharge onsets. This points at a limitation of suspended sediment supply as long as the areas above 2500 m are snow-covered. The positive correlation of annual SSY with glacier cover (among catchments) and glacier mass balances (within a catchment) further supports the importance of the glacier-dominated areas. The analysis of short-term events showed that summer precipitation events were associated with peak sediment concentrations and yields but on average accounted for only 21 % of the annual SSY in the headwaters. These results indicate that under current conditions, thermally induced sediment export (through snow and glacier melt) is dominant in the study area.
Our results extend the scientific knowledge on current hydro-sedimentological conditions in glaciated high-alpine areas and provide a baseline for studies on projected future changes in hydro-sedimentological system dynamics.
Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in cell differentiation and in the pathogenesis of inflammation. The mouse genome involves seven functional Alox genes and the encoded enzymes share a high degree of amino acid conservation with their human orthologs. There are, however, functional differences between mouse and human ALOX orthologs. Human ALOX15B oxygenates arachidonic acid exclusively to its 15-hydroperoxy derivative (15S-HpETE), whereas 8S-HpETE is dominantly formed by mouse Alox15b. The structural basis for this functional difference has been explored and in vitro mutagenesis humanized the reaction specificity of the mouse enzyme. To explore whether this mutagenesis strategy may also humanize the reaction specificity of mouse Alox15b in vivo, we created Alox15b knock-in mice expressing the arachidonic acid 15-lipoxygenating Tyr603Asp+His604Val double mutant instead of the 8-lipoxygenating wildtype enzyme. These mice are fertile, display slightly modified plasma oxylipidomes and develop normally up to an age of 24 weeks. At later developmental stages, male Alox15b-KI mice gain significantly less body weight than outbred wildtype controls, but this effect was not observed for female individuals. To explore the possible reasons for the observed gender-specific growth arrest, we determined the basic hematological parameters and found that aged male Alox15b-KI mice exhibited significantly attenuated red blood cell parameters (erythrocyte counts, hematocrit, hemoglobin). Here again, these differences were not observed in female individuals. These data suggest that humanization of the reaction specificity of mouse Alox15b impairs the functionality of the hematopoietic system in males, which is paralleled by a premature growth arrest.
The first step towards assessing hazards in seismically active regions involves mapping capable faults and estimating their recurrence times. While the mapping of active faults is commonly based on distinct geologic and geomorphic features evident at the surface, mapping blind seismogenic faults is complicated by the absence of on-fault diagnostic features. Here we investigated the Pichilemu Fault in coastal Chile, unknown until it generated a Mw 7.0 earthquake in 2010. The lack of evident surface faulting suggests activity along a partly-hidden blind fault. We used off-fault deformed marine terraces to estimate a fault-slip rate of 0.52 ± 0.04 m/ka, which, when integrated with satellite geodesy suggests a 2.12 ± 0.2 ka recurrence time for Mw~7.0 normal-faulting earthquakes. We propose that extension in the Pichilemu region is associated with stress changes during megathrust earthquakes and accommodated by sporadic slip during upper-plate earthquakes, which has implications for assessing the seismic potential of cryptic faults along convergent margins and elsewhere.
Simultaneous Barcode Sequencing of Diverse Museum Collection Specimens Using a Mixed RNA Bait Set
(2022)
A growing number of publications presenting results from sequencing natural history collection specimens reflect the importance of DNA sequence information from such samples. Ancient DNA extraction and library preparation methods in combination with target gene capture are a way of unlocking archival DNA, including from formalin-fixed wet-collection material. Here we report on an experiment, in which we used an RNA bait set containing baits from a wide taxonomic range of species for DNA hybridisation capture of nuclear and mitochondrial targets for analysing natural history collection specimens. The bait set used consists of 2,492 mitochondrial and 530 nuclear RNA baits and comprises specific barcode loci of diverse animal groups including both invertebrates and vertebrates. The baits allowed to capture DNA sequence information of target barcode loci from 84% of the 37 samples tested, with nuclear markers being captured more frequently and consensus sequences of these being more complete compared to mitochondrial markers. Samples from dry material had a higher rate of success than wet-collection specimens, although target sequence information could be captured from 50% of formalin-fixed samples. Our study illustrates how efforts to obtain barcode sequence information from natural history collection specimens may be combined and are a way of implementing barcoding inventories of scientific collection material.
Isoflux tension propagation (IFTP) theory and Langevin dynamics (LD) simulations are employed to study the dynamics of channel-driven polymer translocation in which a polymer translocates into a narrow channel and the monomers in the channel experience a driving force fc. In the high driving force limit, regardless of the channel width, IFTP theory predicts τ ∝ f βc for the translocation time, where β = −1 is the force scaling exponent. Moreover, LD data show that for a very narrow channel fitting only a single file of monomers, the entropic force due to the subchain inside the channel does not play a significant role in the translocation dynamics and the force exponent β = −1 regardless of the force magnitude. As the channel width increases the number of possible spatial configurations of the subchain inside the channel becomes significant and the resulting entropic force causes the force exponent to drop below unity.
We consider a one-dimensional oscillatory medium with a coupling through a diffusive linear field. In the limit of fast diffusion this setup reduces to the classical Kuramoto–Battogtokh model. We demonstrate that for a finite diffusion stable chimera solitons, namely localized synchronous domain in an infinite asynchronous environment, are possible. The solitons are stable also for finite density of oscillators, but in this case they sway with a nearly constant speed. This finite-density-induced motility disappears in the continuum limit, as the velocity of the solitons is inverse proportional to the density. A long-wave instability of the homogeneous asynchronous state causes soliton turbulence, which appears as a sequence of soliton mergings and creations. As the instability of the asynchronous state becomes stronger, this turbulence develops into a spatio-temporal intermittency.