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Year of publication
Language
- English (29)
Keywords
Institute
- Institut für Physik und Astronomie (8)
- Institut für Biochemie und Biologie (4)
- Institut für Chemie (4)
- Hasso-Plattner-Institut für Digital Engineering GmbH (3)
- Mathematisch-Naturwissenschaftliche Fakultät (3)
- Department Psychologie (2)
- Institut für Geowissenschaften (2)
- Institut für Umweltwissenschaften und Geographie (2)
- Institut für Ernährungswissenschaft (1)
- Institut für Informatik und Computational Science (1)
A catalog of genetic loci associated with kidney function from analyses of a million individuals
(2019)
Wuttke, Matthias ; Li, Yong ; Li, Man ; Sieber, Karsten B. ; Feitosa, Mary F. ; Gorski, Mathias ; Tin, Adrienne ; Wang, Lihua ; Chu, Audrey Y. ; Hoppmann, Anselm ; Kirsten, Holger ; Giri, Ayush ; Chai, Jin-Fang ; Sveinbjornsson, Gardar ; Tayo, Bamidele O. ; Nutile, Teresa ; Fuchsberger, Christian ; Marten, Jonathan ; Cocca, Massimiliano ; Ghasemi, Sahar ; Xu, Yizhe ; Horn, Katrin ; Noce, Damia ; Van der Most, Peter J. ; Sedaghat, Sanaz ; Yu, Zhi ; Akiyama, Masato ; Afaq, Saima ; Ahluwalia, Tarunveer Singh ; Almgren, Peter ; Amin, Najaf ; Arnlov, Johan ; Bakker, Stephan J. L. ; Bansal, Nisha ; Baptista, Daniela ; Bergmann, Sven ; Biggs, Mary L. ; Biino, Ginevra ; Boehnke, Michael ; Boerwinkle, Eric ; Boissel, Mathilde ; Böttinger, Erwin ; Boutin, Thibaud S. ; Brenner, Hermann ; Brumat, Marco ; Burkhardt, Ralph ; Butterworth, Adam S. ; Campana, Eric ; Campbell, Archie ; Campbell, Harry ; Canouil, Mickael ; Carroll, Robert J. ; Catamo, Eulalia ; Chambers, John C. ; Chee, Miao-Ling ; Chee, Miao-Li ; Chen, Xu ; Cheng, Ching-Yu ; Cheng, Yurong ; Christensen, Kaare ; Cifkova, Renata ; Ciullo, Marina ; Concas, Maria Pina ; Cook, James P. ; Coresh, Josef ; Corre, Tanguy ; Sala, Cinzia Felicita ; Cusi, Daniele ; Danesh, John ; Daw, E. Warwick ; De Borst, Martin H. ; De Grandi, Alessandro ; De Mutsert, Renee ; De Vries, Aiko P. J. ; Degenhardt, Frauke ; Delgado, Graciela ; Demirkan, Ayse ; Di Angelantonio, Emanuele ; Dittrich, Katalin ; Divers, Jasmin ; Dorajoo, Rajkumar ; Eckardt, Kai-Uwe ; Ehret, Georg ; Elliott, Paul ; Endlich, Karlhans ; Evans, Michele K. ; Felix, Janine F. ; Foo, Valencia Hui Xian ; Franco, Oscar H. ; Franke, Andre ; Freedman, Barry I. ; Freitag-Wolf, Sandra ; Friedlander, Yechiel ; Froguel, Philippe ; Gansevoort, Ron T. ; Gao, He ; Gasparini, Paolo ; Gaziano, J. Michael ; Giedraitis, Vilmantas ; Gieger, Christian ; Girotto, Giorgia ; Giulianini, Franco ; Gogele, Martin ; Gordon, Scott D. ; Gudbjartsson, Daniel F. ; Gudnason, Vilmundur ; Haller, Toomas ; Hamet, Pavel ; Harris, Tamara B. ; Hartman, Catharina A. ; Hayward, Caroline ; Hellwege, Jacklyn N. ; Heng, Chew-Kiat ; Hicks, Andrew A. ; Hofer, Edith ; Huang, Wei ; Hutri-Kahonen, Nina ; Hwang, Shih-Jen ; Ikram, M. Arfan ; Indridason, Olafur S. ; Ingelsson, Erik ; Ising, Marcus ; Jaddoe, Vincent W. V. ; Jakobsdottir, Johanna ; Jonas, Jost B. ; Joshi, Peter K. ; Josyula, Navya Shilpa ; Jung, Bettina ; Kahonen, Mika ; Kamatani, Yoichiro ; Kammerer, Candace M. ; Kanai, Masahiro ; Kastarinen, Mika ; Kerr, Shona M. ; Khor, Chiea-Chuen ; Kiess, Wieland ; Kleber, Marcus E. ; Koenig, Wolfgang ; Kooner, Jaspal S. ; Korner, Antje ; Kovacs, Peter ; Kraja, Aldi T. ; Krajcoviechova, Alena ; Kramer, Holly ; Kramer, Bernhard K. ; Kronenberg, Florian ; Kubo, Michiaki ; Kuhnel, Brigitte ; Kuokkanen, Mikko ; Kuusisto, Johanna ; La Bianca, Martina ; Laakso, Markku ; Lange, Leslie A. ; Langefeld, Carl D. ; Lee, Jeannette Jen-Mai ; Lehne, Benjamin ; Lehtimaki, Terho ; Lieb, Wolfgang ; Lim, Su-Chi ; Lind, Lars ; Lindgren, Cecilia M. ; Liu, Jun ; Liu, Jianjun ; Loeffler, Markus ; Loos, Ruth J. F. ; Lucae, Susanne ; Lukas, Mary Ann ; Lyytikainen, Leo-Pekka ; Magi, Reedik ; Magnusson, Patrik K. E. ; Mahajan, Anubha ; Martin, Nicholas G. ; Martins, Jade ; Marz, Winfried ; Mascalzoni, Deborah ; Matsuda, Koichi ; Meisinger, Christa ; Meitinger, Thomas ; Melander, Olle ; Metspalu, Andres ; Mikaelsdottir, Evgenia K. ; Milaneschi, Yuri ; Miliku, Kozeta ; Mishra, Pashupati P. ; Program, V. A. Million Veteran ; Mohlke, Karen L. ; Mononen, Nina ; Montgomery, Grant W. ; Mook-Kanamori, Dennis O. ; Mychaleckyj, Josyf C. ; Nadkarni, Girish N. ; Nalls, Mike A. ; Nauck, Matthias ; Nikus, Kjell ; Ning, Boting ; Nolte, Ilja M. ; Noordam, Raymond ; Olafsson, Isleifur ; Oldehinkel, Albertine J. ; Orho-Melander, Marju ; Ouwehand, Willem H. ; Padmanabhan, Sandosh ; Palmer, Nicholette D. ; Palsson, Runolfur ; Penninx, Brenda W. J. H. ; Perls, Thomas ; Perola, Markus ; Pirastu, Mario ; Pirastu, Nicola ; Pistis, Giorgio ; Podgornaia, Anna I. ; Polasek, Ozren ; Ponte, Belen ; Porteous, David J. ; Poulain, Tanja ; Pramstaller, Peter P. ; Preuss, Michael H. ; Prins, Bram P. ; Province, Michael A. ; Rabelink, Ton J. ; Raffield, Laura M. ; Raitakari, Olli T. ; Reilly, Dermot F. ; Rettig, Rainer ; Rheinberger, Myriam ; Rice, Kenneth M. ; Ridker, Paul M. ; Rivadeneira, Fernando ; Rizzi, Federica ; Roberts, David J. ; Robino, Antonietta ; Rossing, Peter ; Rudan, Igor ; Rueedi, Rico ; Ruggiero, Daniela ; Ryan, Kathleen A. ; Saba, Yasaman ; Sabanayagam, Charumathi ; Salomaa, Veikko ; Salvi, Erika ; Saum, Kai-Uwe ; Schmidt, Helena ; Schmidt, Reinhold ; Ben Schottker ; Schulz, Christina-Alexandra ; Schupf, Nicole ; Shaffer, Christian M. ; Shi, Yuan ; Smith, Albert V. ; Smith, Blair H. ; Soranzo, Nicole ; Spracklen, Cassandra N. ; Strauch, Konstantin ; Stringham, Heather M. ; Stumvoll, Michael ; Svensson, Per O. ; Szymczak, Silke ; Tai, E-Shyong ; Tajuddin, Salman M. ; Tan, Nicholas Y. Q. ; Taylor, Kent D. ; Teren, Andrej ; Tham, Yih-Chung ; Thiery, Joachim ; Thio, Chris H. L. ; Thomsen, Hauke ; Thorleifsson, Gudmar ; Toniolo, Daniela ; Tonjes, Anke ; Tremblay, Johanne ; Tzoulaki, Ioanna ; Uitterlinden, Andre G. ; Vaccargiu, Simona ; Van Dam, Rob M. ; Van der Harst, Pim ; Van Duijn, Cornelia M. ; Edward, Digna R. Velez ; Verweij, Niek ; Vogelezang, Suzanne ; Volker, Uwe ; Vollenweider, Peter ; Waeber, Gerard ; Waldenberger, Melanie ; Wallentin, Lars ; Wang, Ya Xing ; Wang, Chaolong ; Waterworth, Dawn M. ; Bin Wei, Wen ; White, Harvey ; Whitfield, John B. ; Wild, Sarah H. ; Wilson, James F. ; Wojczynski, Mary K. ; Wong, Charlene ; Wong, Tien-Yin ; Xu, Liang ; Yang, Qiong ; Yasuda, Masayuki ; Yerges-Armstrong, Laura M. ; Zhang, Weihua ; Zonderman, Alan B. ; Rotter, Jerome I. ; Bochud, Murielle ; Psaty, Bruce M. ; Vitart, Veronique ; Wilson, James G. ; Dehghan, Abbas ; Parsa, Afshin ; Chasman, Daniel I. ; Ho, Kevin ; Morris, Andrew P. ; Devuyst, Olivier ; Akilesh, Shreeram ; Pendergrass, Sarah A. ; Sim, Xueling ; Boger, Carsten A. ; Okada, Yukinori ; Edwards, Todd L. ; Snieder, Harold ; Stefansson, Kari ; Hung, Adriana M. ; Heid, Iris M. ; Scholz, Markus ; Teumer, Alexander ; Kottgen, Anna ; Pattaro, Cristian
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Abdo, A. A. ; Ackermann, Margit ; Ajello, M. ; Allafort, A. J. ; Baldini, L. ; Ballet, J. ; Barbiellini, G. ; Baring, M. G. ; Bastieri, D. ; Bechtol, K. C. ; Bellazzini, R. ; Berenji, B. ; Blandford, R. D. ; Bloom, E. D. ; Bonamente, E. ; Borgland, A. W. ; Bouvier, A. ; Brandt, T. J. ; Bregeon, Johan ; Brez, A. ; Brigida, M. ; Bruel, P. ; Buehler, R. ; Buson, S. ; Caliandro, G. A. ; Cameron, R. A. ; Cannon, A. ; Caraveo, P. A. ; Carrigan, Svenja ; Casandjian, J. M. ; Cavazzuti, E. ; Cecchi, C. ; Celik, O. ; Charles, E. ; Chekhtman, A. ; Cheung, C. C. ; Chiang, J. ; Ciprini, S. ; Claus, R. ; Cohen-Tanugi, J. ; Conrad, Jan ; Cutini, S. ; Dermer, C. D. ; de Palma, F. ; do Couto e Silva, E. ; Drell, P. S. ; Dubois, R. ; Dumora, D. ; Favuzzi, C. ; Fegan, S. J. ; Ferrara, E. C. ; Focke, W. B. ; Fortin, P. ; Frailis, M. ; Fuhrmann, L. ; Fukazawa, Y. ; Funk, S. ; Fusco, P. ; Gargano, F. ; Gasparrini, D. ; Gehrels, N. ; Germani, S. ; Giglietto, N. ; Giordano, F. ; Giroletti, M. ; Glanzman, T. ; Godfrey, G. ; Grenier, I. A. ; Guillemot, L. ; Guiriec, S. ; Hayashida, M. ; Hays, E. ; Horan, D. ; Hughes, R. E. ; Johannesson, G. ; Johnson, A. S. ; Johnson, W. N. ; Kadler, M. ; Kamae, T. ; Katagiri, H. ; Kataoka, J. ; Knoedlseder, J. ; Kuss, M. ; Lande, J. ; Latronico, L. ; Lee, S. -H. ; Lemoine-Goumard, M. ; Longo, F. ; Loparco, F. ; Lott, B. ; Lovellette, M. N. ; Lubrano, P. ; Madejski, G. M. ; Makeev, A. ; Max-Moerbeck, W. ; Mazziotta, Mario Nicola ; McEnery, J. E. ; Mehault, J. ; Michelson, P. F. ; Mitthumsiri, W. ; Mizuno, T. ; Moiseev, A. A. ; Monte, C. ; Monzani, M. E. ; Morselli, A. ; Moskalenko, I. V. ; Murgia, S. ; Naumann-Godo, M. ; Nishino, S. ; Nolan, P. L. ; Norris, J. P. ; Nuss, E. ; Ohsugi, T. ; Okumura, A. ; Omodei, N. ; Orlando, E. ; Ormes, J. F. ; Paneque, D. ; Panetta, J. H. ; Parent, D. ; Pavlidou, V. ; Pearson, T. J. ; Pelassa, V. ; Pepe, M. ; Pesce-Rollins, M. ; Piron, F. ; Porter, T. A. ; Raino, S. ; Rando, R. ; Razzano, M. ; Readhead, A. ; Reimer, A. ; Reimer, O. ; Richards, J. L. ; Ripken, J. ; Ritz, S. ; Roth, M. ; Sadrozinski, H. F. -W. ; Sanchez, D. ; Sander, A. ; Scargle, J. D. ; Sgro, C. ; Siskind, E. J. ; Smith, P. D. ; Spandre, G. ; Spinelli, P. ; Stawarz, L. ; Stevenson, M. ; Strickman, M. S. ; Sokolovsky, K. V. ; Suson, D. J. ; Takahashi, H. ; Takahashi, T. ; Tanaka, T. ; Thayer, J. B. ; Thayer, J. G. ; Thompson, D. J. ; Tibaldo, L. ; Torres, F. ; Tosti, G. ; Tramacere, A. ; Uchiyama, Y. ; Usher, T. L. ; Vandenbroucke, J. ; Vasileiou, V. ; Vilchez, N. ; Vitale, V. ; Waite, A. P. ; Wang, P. ; Wehrle, A. E. ; Winer, B. L. ; Wood, K. S. ; Yang, Z. ; Ylinen, T. ; Zensus, J. A. ; Ziegler, M. ; Aleksic, J. ; Antonelli, L. A. ; Antoranz, P. ; Backes, Michael ; Barrio, J. A. ; Gonzalez, J. Becerra ; Bednarek, W. ; Berdyugin, A. ; Berger, K. ; Bernardini, E. ; Biland, A. ; Blanch Bigas, O. ; Bock, R. K. ; Boller, A. ; Bonnoli, G. ; Bordas, Pol ; Tridon, D. Borla ; Bosch-Ramon, Valentin ; Bose, D. ; Braun, I. ; Bretz, T. ; Camara, M. ; Carmona, E. ; Carosi, A. ; Colin, P. ; Colombo, E. ; Contreras, J. L. ; Cortina, J. ; Covino, S. ; Dazzi, F. ; de Angelis, A. ; del Pozo, E. De Cea ; De Lotto, B. ; De Maria, M. ; De Sabata, F. ; Mendez, C. Delgado ; Ortega, A. Diago ; Doert, M. ; Dominguez, A. ; Prester, Dijana Dominis ; Dorner, D. ; Doro, M. ; Elsaesser, D. ; Ferenc, D. ; Fonseca, M. V. ; Font, L. ; Lopen, R. J. Garcia ; Garczarczyk, M. ; Gaug, M. ; Giavitto, G. ; Godinovi, N. ; Hadasch, D. ; Herrero, A. ; Hildebrand, D. ; Hoehne-Moench, D. ; Hose, J. ; Hrupec, D. ; Jogler, T. ; Klepser, S. ; Kraehenbuehl, T. ; Kranich, D. ; Krause, J. ; La Barbera, A. ; Leonardo, E. ; Lindfors, E. ; Lombardi, S. ; Lopez, M. ; Lorenz, E. ; Majumdar, P. ; Makariev, E. ; Maneva, G. ; Mankuzhiyil, N. ; Mannheim, K. ; Maraschi, L. ; Mariotti, M. ; Martinez, M. ; Mazin, D. ; Meucci, M. ; Miranda, J. M. ; Mirzoyan, R. ; Miyamoto, H. ; Moldon, J. ; Moralejo, A. ; Nieto, D. ; Nilsson, K. ; Orito, R. ; Oya, I. ; Paoletti, R. ; Paredes, J. M. ; Partini, S. ; Pasanen, M. ; Pauss, F. ; Pegna, R. G. ; Perez-Torres, M. A. ; Persic, M. ; Peruzzo, J. ; Pochon, J. ; Moroni, P. G. Prada ; Prada, F. ; Prandini, E. ; Puchades, N. ; Puljak, I. ; Reichardt, T. ; Reinthal, R. ; Rhode, W. ; Ribo, M. ; Rico, J. ; Rissi, M. ; Ruegamer, S. ; Saggion, A. ; Saito, K. ; Saito, T. Y. ; Salvati, M. ; Sanchez-Conde, M. ; Satalecka, K. ; Scalzotto, V. ; Scapin, V. ; Schultz, C. ; Schweizer, T. ; Shayduk, M. ; Shore, S. N. ; Sierpowska-Bartosik, A. ; Sillanpaa, A. ; Sitarek, J. ; Sobczynska, D. ; Spanier, F. ; Spiro, S. ; Stamerra, A. ; Steinke, B. ; Storz, J. ; Strah, N. ; Struebig, J. C. ; Suric, T. ; Takalo, L. O. ; Tavecchio, F. ; Temnikov, P. ; Terzic, T. ; Tescaro, D. ; Teshima, M. ; Vankov, H. ; Wagner, R. M. ; Weitzel, Q. ; Zabalza, V. ; Zandanel, F. ; Zanin, R. ; Acciari, V. A. ; Arlen, T. ; Aune, T. ; Benbow, W. ; Boltuch, D. ; Bradbury, S. M. ; Buckley, J. H. ; Bugaev, V. ; Cannon, A. ; Cesarini, A. ; Ciupik, L. ; Cui, W. ; Dickherber, R. ; Errando, M. ; Falcone, A. ; Finley, J. P. ; Finnegan, G. ; Fortson, L. ; Furniss, A. ; Galante, N. ; Gall, D. ; Gillanders, G. H. ; Godambe, S. ; Grube, J. ; Guenette, R. ; Gyuk, G. ; Hanna, D. ; Holder, J. ; Huang, D. ; Hui, C. M. ; Humensky, T. B. ; Kaaret, P. ; Karlsson, N. ; Kertzman, M. ; Kieda, D. ; Konopelko, A. ; Krawczynski, H. ; Krennrich, F. ; Lang, M. J. ; Maier, G. ; McArthur, S. ; McCann, A. ; McCutcheon, M. ; Moriarty, P. ; Mukherjee, R. ; Ong, R. ; Otte, N. ; Pandel, D. ; Perkins, J. S. ; Pichel, A. ; Pohl, M. ; Quinn, J. ; Ragan, K. ; Reyes, L. C. ; Reynolds, P. T. ; Roache, E. ; Rose, H. J. ; Rovero, A. C. ; Schroedter, M. ; Sembroski, G. H. ; Senturk, G. D. ; Steele, D. ; Swordy, S. P. ; Tesic, G. ; Theiling, M. ; Thibadeau, S. ; Varlotta, A. ; Vincent, S. ; Wakely, S. P. ; Ward, J. E. ; Weekes, T. C. ; Weinstein, A. ; Weisgarber, T. ; Williams, D. A. ; Wood, M. ; Zitzer, B. ; Villata, M. ; Raiteri, C. M. ; Aller, H. D. ; Aller, M. F. ; Arkharov, A. A. ; Blinov, D. A. ; Calcidese, P. ; Chen, W. P. ; Efimova, N. V. ; Kimeridze, G. ; Konstantinova, T. S. ; Kopatskaya, E. N. ; Koptelova, E. ; Kurtanidze, O. M. ; Kurtanidze, S. O. ; Lahteenmaki, A. ; Larionov, V. M. ; Larionova, E. G. ; Larionova, L. V. ; Ligustri, R. ; Morozova, D. A. ; Nikolashvili, M. G. ; Sigua, L. A. ; Troitsky, I. S. ; Angelakis, E. ; Capalbi, M. ; Carraminana, A. ; Carrasco, L. ; Cassaro, P. ; de la Fuente, E. ; Gurwell, M. A. ; Kovalev, Y. Y. ; Kovalev, Yu. A. ; Krichbaum, T. P. ; Krimm, H. A. ; Leto, Paolo ; Lister, M. L. ; Maccaferri, G. ; Moody, J. W. ; Mori, Y. ; Nestoras, I. ; Orlati, A. ; Pagani, C. ; Pace, C. ; Pearson, R. ; Perri, M. ; Piner, B. G. ; Pushkarev, A. B. ; Ros, E. ; Sadun, A. C. ; Sakamoto, T. ; Tornikoski, M. ; Yatsu, Y. ; Zook, A.
We report on the gamma-ray activity of the blazar Mrk 501 during the first 480 days of Fermi operation. We find that the average Large Area Telescope (LAT) gamma-ray spectrum of Mrk 501 can be well described by a single power-law function with a photon index of 1.78 +/- 0.03. While we observe relatively mild flux variations with the Fermi-LAT (within less than a factor of two), we detect remarkable spectral variability where the hardest observed spectral index within the LAT energy range is 1.52 +/- 0.14, and the softest one is 2.51 +/- 0.20. These unexpected spectral changes do not correlate with the measured flux variations above 0.3 GeV. In this paper, we also present the first results from the 4.5 month long multifrequency campaign (2009 March 15-August 1) on Mrk 501, which included the Very Long Baseline Array (VLBA), Swift, RXTE, MAGIC, and VERITAS, the F-GAMMA, GASP-WEBT, and other collaborations and instruments which provided excellent temporal and energy coverage of the source throughout the entire campaign. The extensive radio to TeV data set from this campaign provides us with the most detailed spectral energy distribution yet collected for this source during its relatively low activity. The average spectral energy distribution of Mrk 501 is well described by the standard one-zone synchrotron self-Compton (SSC) model. In the framework of this model, we find that the dominant emission region is characterized by a size less than or similar to 0.1 pc (comparable within a factor of few to the size of the partially resolved VLBA core at 15-43 GHz), and that the total jet power (similar or equal to 10(44) erg s(-1)) constitutes only a small fraction (similar to 10(-3)) of the Eddington luminosity. The energy distribution of the freshly accelerated radiating electrons required to fit the time-averaged data has a broken power-law form in the energy range 0.3 GeV-10 TeV, with spectral indices 2.2 and 2.7 below and above the break energy of 20 GeV. We argue that such a form is consistent with a scenario in which the bulk of the energy dissipation within the dominant emission zone of Mrk 501 is due to relativistic, proton-mediated shocks. We find that the ultrarelativistic electrons and mildly relativistic protons within the blazar zone, if comparable in number, are in approximate energy equipartition, with their energy dominating the jet magnetic field energy by about two orders of magnitude.
Observations of the young supernova remnant RX J1713.7-3946 with the fermi large area telescope
(2011)
Abdo, A. A. ; Ackermann, Margit ; Ajello, M. ; Allafort, A. J. ; Baldini, L. ; Ballet, J. ; Barbiellini, G. ; Baring, M. G. ; Bastieri, D. ; Bellazzini, R. ; Berenji, B. ; Blandford, R. D. ; Bloom, E. D. ; Bonamente, E. ; Borgland, A. W. ; Bouvier, A. ; Brandt, T. J. ; Bregeon, Johan ; Brigida, M. ; Bruel, P. ; Buehler, R. ; Buson, S. ; Caliandro, G. A. ; Cameron, R. A. ; Caraveo, P. A. ; Casandjian, J. M. ; Cecchi, C. ; Chaty, S. ; Chekhtman, A. ; Cheung, C. C. ; Chiang, J. ; Cillis, A. N. ; Ciprini, S. ; Claus, R. ; Cohen-Tanugi, J. ; Conrad, Jan ; Corbel, S. ; Cutini, S. ; de Angelis, A. ; de Palma, F. ; Dermer, C. D. ; Digel, S. W. ; do Couto e Silva, E. ; Drell, P. S. ; Drlica-Wagner, A. ; Dubois, R. ; Dumora, D. ; Favuzzi, C. ; Ferrara, E. C. ; Fortin, P. ; Frailis, M. ; Fukazawa, Y. ; Fukui, Y. ; Funk, S. ; Fusco, P. ; Gargano, F. ; Gasparrini, D. ; Gehrels, N. ; Germani, S. ; Giglietto, N. ; Giordano, F. ; Giroletti, M. ; Glanzman, T. ; Godfrey, G. ; Grenier, I. A. ; Grondin, M. -H. ; Guiriec, S. ; Hadasch, D. ; Hanabata, Y. ; Harding, A. K. ; Hayashida, M. ; Hayashi, K. ; Hays, E. ; Horan, D. ; Jackson, M. S. ; Johannesson, G. ; Johnson, A. S. ; Kamae, T. ; Katagiri, H. ; Kataoka, J. ; Kerr, M. ; Knoedlseder, J. ; Kuss, M. ; Lande, J. ; Latronico, L. ; Lee, S. -H. ; Lemoine-Goumard, M. ; Longo, F. ; Loparco, F. ; Lovellette, M. N. ; Lubrano, P. ; Madejski, G. M. ; Makeev, A. ; Mazziotta, Mario Nicola ; McEnery, J. E. ; Michelson, P. F. ; Mignani, R. P. ; Mitthumsiri, W. ; Mizuno, T. ; Moiseev, A. A. ; Monte, C. ; Monzani, M. E. ; Morselli, A. ; Moskalenko, I. V. ; Murgia, S. ; Naumann-Godo, M. ; Nolan, P. L. ; Norris, J. P. ; Nuss, E. ; Ohsugi, T. ; Okumura, A. ; Orlando, E. ; Ormes, J. F. ; Paneque, D. ; Parent, D. ; Pelassa, V. ; Pesce-Rollins, M. ; Pierbattista, M. ; Piron, F. ; Pohl, Martin ; Porter, T. A. ; Raino, S. ; Rando, R. ; Razzano, M. ; Reimer, O. ; Reposeur, T. ; Ritz, S. ; Romani, R. W. ; Roth, M. ; Sadrozinski, H. F. -W. ; Parkinson, P. M. Saz ; Sgro, C. ; Smith, D. A. ; Smith, P. D. ; Spandre, G. ; Spinelli, P. ; Strickman, M. S. ; Tajima, H. ; Takahashi, H. ; Takahashi, T. ; Tanaka, T. ; Thayer, J. G. ; Thayer, J. B. ; Thompson, D. J. ; Tibaldo, L. ; Tibolla, O. ; Torres, D. F. ; Tosti, G. ; Tramacere, A. ; Troja, E. ; Uchiyama, Y. ; Vandenbroucke, J. ; Vasileiou, V. ; Vianello, G. ; Vilchez, N. ; Vitale, V. ; Waite, A. P. ; Wang, P. ; Winer, B. L. ; Wood, K. S. ; Yamamoto, H. ; Yamazaki, R. ; Yang, Z. ; Ziegler, M.
We present observations of the young supernova remnant (SNR) RX J1713.7-3946 with the Fermi Large Area Telescope (LAT). We clearly detect a source positionally coincident with the SNR. The source is extended with a best-fit extension of 0 degrees.55 +/- 0 degrees.04 matching the size of the non-thermal X-ray and TeV gamma-ray emission from the remnant. The positional coincidence and the matching extended emission allow us to identify the LAT source with SNR RX J1713.7-3946. The spectrum of the source can be described by a very hard power law with a photon index of Gamma = 1.5 +/- 0.1 that coincides in normalization with the steeper H. E. S. S.-detected gamma-ray spectrum at higher energies. The broadband gamma-ray emission is consistent with a leptonic origin as the dominant mechanism for the gamma-ray emission.
De Angelis, A. ; Tatischeff, V. ; Grenier, I. A. ; McEnery, J. ; Mallamaci, Manuela ; Tavani, M. ; Oberlack, U. ; Hanlon, L. ; Walter, R. ; Argan, A. ; Von Ballmoos, P. ; Bulgarelli, A. ; Bykov, A. ; Hernanz, M. ; Kanbach, G. ; Kuvvetli, I. ; Pearce, M. ; Zdziarski, A. ; Conrad, J. ; Ghisellini, G. ; Harding, A. ; Isern, J. ; Leising, M. ; Longo, F. ; Madejski, G. ; Martinez, M. ; Mazziotta, Mario Nicola ; Paredes, J. M. ; Pohl, Martin ; Rando, R. ; Razzano, M. ; Aboudan, A. ; Ackermann, M. ; Addazi, A. ; Ajello, M. ; Albertus, C. ; Alvarez, J. M. ; Ambrosi, G. ; Anton, S. ; Antonelli, L. A. ; Babic, A. ; Baibussinov, B. ; Balbom, M. ; Baldini, L. ; Balman, S. ; Bambi, C. ; Barres de Almeida, U. ; Barrio, J. A. ; Bartels, R. ; Bastieri, D. ; Bednarek, W. ; Bernard, D. ; Bernardini, E. ; Bernasconi, T. ; Bertucci, B. ; Biland, A. ; Bissaldi, E. ; Boettcher, M. ; Bonvicini, V. ; Bosch-Ramon, V. ; Bottacini, E. ; Bozhilov, V. ; Bretz, T. ; Branchesi, M. ; Brdar, V. ; Bringmann, T. ; Brogna, A. ; Jorgensen, C. Budtz ; Busetto, G. ; Buson, S. ; Busso, M. ; Caccianiga, A. ; Camera, S. ; Campana, R. ; Caraveo, P. ; Cardillo, M. ; Carlson, P. ; Celestin, S. ; Cermeno, M. ; Chen, A. ; Cheung, C. C. ; Churazov, E. ; Ciprini, S. ; Coc, A. ; Colafrancesco, S. ; Coleiro, A. ; Collmar, W. ; Coppi, P. ; Curado da Silva, R. ; Cutini, S. ; De Lotto, B. ; de Martino, D. ; De Rosa, A. ; Del Santo, M. ; Delgado, L. ; Diehl, R. ; Dietrich, S. ; Dolgov, A. D. ; Dominguez, A. ; Prester, D. Dominis ; Donnarumma, I. ; Dorner, D. ; Doro, M. ; Dutra, M. ; Elsaesser, D. ; Fabrizio, M. ; Fernandez-Barral, A. ; Fioretti, V. ; Foffano, L. ; Formato, V. ; Fornengo, N. ; Foschini, L. ; Franceschini, A. ; Franckowiak, A. ; Funk, S. ; Fuschino, F. ; Gaggero, D. ; Galanti, G. ; Gargano, F. ; Gasparrini, D. ; Gehrz, R. ; Giammaria, P. ; Giglietto, N. ; Giommi, P. ; Giordano, F. ; Giroletti, M. ; Ghirlanda, G. ; Godinovic, N. ; Gouiffes, C. ; Grove, J. E. ; Hamadache, C. ; Hartmann, D. H. ; Hayashida, M. ; Hryczuk, A. ; Jean, P. ; Johnson, T. ; Jose, J. ; Kaufmann, S. ; Khelifi, B. ; Kiener, J. ; Knodlseder, J. ; Kolem, M. ; Kopp, J. ; Kozhuharov, V. ; Labanti, C. ; Lalkovski, S. ; Laurent, P. ; Limousin, O. ; Linares, M. ; Lindfors, E. ; Lindner, M. ; Liu, J. ; Lombardi, S. ; Loparco, F. ; Lopez-Coto, R. ; Lopez Moya, M. ; Lott, B. ; Lubrano, P. ; Malyshev, D. ; Mankuzhiyil, N. ; Mannheim, K. ; Marcha, M. J. ; Marciano, A. ; Marcote, B. ; Mariotti, M. ; Marisaldi, M. ; McBreen, S. ; Mereghetti, S. ; Merle, A. ; Mignani, R. ; Minervini, G. ; Moiseev, A. ; Morselli, A. ; Moura, F. ; Nakazawa, K. ; Nava, L. ; Nieto, D. ; Orienti, M. ; Orio, M. ; Orlando, E. ; Orleanski, P. ; Paiano, S. ; Paoletti, R. ; Papitto, A. ; Pasquato, M. ; Patricelli, B. ; Perez-Garcia, M. A. ; Persic, M. ; Piano, G. ; Pichel, A. ; Pimenta, M. ; Pittori, C. ; Porter, T. ; Poutanen, J. ; Prandini, E. ; Prantzos, N. ; Produit, N. ; Profumo, S. ; Queiroz, F. S. ; Raino, S. ; Raklev, A. ; Regis, M. ; Reichardt, I. ; Rephaeli, Y. ; Rico, J. ; Rodejohann, W. ; Fernandez, G. Rodriguez ; Roncadelli, M. ; Roso, L. ; Rovero, A. ; Ruffini, R. ; Sala, G. ; Sanchez-Conde, M. A. ; Santangelo, Andrea ; Parkinson, P. Saz ; Sbarrato, T. ; Shearer, A. ; Shellard, R. ; Short, K. ; Siegert, T. ; Siqueira, C. ; Spinelli, P. ; Stamerra, A. ; Starrfield, S. ; Strong, A. ; Strumke, I. ; Tavecchio, F. ; Taverna, R. ; Terzic, T. ; Thompson, D. J. ; Tibolla, O. ; Torres, D. F. ; Turolla, R. ; Ulyanov, A. ; Ursi, A. ; Vacchi, A. ; Van den Abeele, J. ; Vankova-Kirilovai, G. ; Venter, C. ; Verrecchia, F. ; Vincent, P. ; Wang, X. ; Weniger, C. ; Wu, X. ; Zaharijas, G. ; Zampieri, L. ; Zane, S. ; Zimmer, S. ; Zoglauer, A.
Ackermann, Margit ; Ajello, M. ; Allafort, A. J. ; Baldini, L. ; Ballet, J. ; Barbiellini, G. ; Bastieri, D. ; Belfiore, A. ; Bellazzini, R. ; Berenji, B. ; Blandford, R. D. ; Bloom, E. D. ; Bonamente, E. ; Borgland, A. W. ; Bottacini, E. ; Brigida, M. ; Bruel, P. ; Buehler, R. ; Buson, S. ; Caliandro, G. A. ; Cameron, R. A. ; Caraveo, P. A. ; Casandjian, J. M. ; Cecchi, C. ; Chekhtman, A. ; Cheung, C. C. ; Chiang, J. ; Ciprini, S. ; Claus, R. ; Cohen-Tanugi, J. ; de Angelis, A. ; de Palma, F. ; Dermer, C. D. ; do Couto e Silva, E. ; Drell, P. S. ; Dumora, D. ; Favuzzi, C. ; Fegan, S. J. ; Focke, W. B. ; Fortin, P. ; Fukazawa, Y. ; Fusco, P. ; Gargano, F. ; Germani, S. ; Giglietto, N. ; Giordano, F. ; Giroletti, M. ; Glanzman, T. ; Godfrey, G. ; Grenier, I. A. ; Guillemot, L. ; Guiriec, S. ; Hadasch, D. ; Hanabata, Y. ; Harding, A. K. ; Hayashida, M. ; Hayashi, K. ; Hays, E. ; Johannesson, G. ; Johnson, A. S. ; Kamae, T. ; Katagiri, H. ; Kataoka, J. ; Kerr, M. ; Knoedlseder, J. ; Kuss, M. ; Lande, J. ; Latronico, L. ; Lee, S. -H. ; Longo, F. ; Loparco, F. ; Lott, B. ; Lovellette, M. N. ; Lubrano, P. ; Martin, P. ; Mazziotta, Mario Nicola ; McEnery, J. E. ; Mehault, J. ; Michelson, P. F. ; Mitthumsiri, W. ; Mizuno, T. ; Monte, C. ; Monzani, M. E. ; Morselli, A. ; Moskalenko, I. V. ; Murgia, S. ; Naumann-Godo, M. ; Nolan, P. L. ; Norris, J. P. ; Nuss, E. ; Ohsugi, T. ; Okumura, A. ; Orlando, E. ; Ormes, J. F. ; Ozaki, M. ; Paneque, D. ; Parent, D. ; Pesce-Rollins, M. ; Pierbattista, M. ; Piron, F. ; Pohl, Martin ; Prokhorov, D. ; Raino, S. ; Rando, R. ; Razzano, M. ; Reposeur, T. ; Ritz, S. ; Parkinson, P. M. Saz ; Sgro, C. ; Siskind, E. J. ; Smith, P. D. ; Spinelli, P. ; Strong, A. W. ; Takahashi, H. ; Tanaka, T. ; Thayer, J. G. ; Thayer, J. B. ; Thompson, D. J. ; Tibaldo, L. ; Torres, D. F. ; Tosti, G. ; Tramacere, A. ; Troja, E. ; Uchiyama, Y. ; Vandenbroucke, J. ; Vasileiou, V. ; Vianello, G. ; Vitale, V. ; Waite, A. P. ; Wang, P. ; Winer, B. L. ; Wood, K. S. ; Yang, Z. ; Zimmer, S. ; Bontemps, S.
The origin of Galactic cosmic rays is a century-long puzzle. Indirect evidence points to their acceleration by supernova shockwaves, but we know little of their escape from the shock and their evolution through the turbulent medium surrounding massive stars. Gamma rays can probe their spreading through the ambient gas and radiation fields. The Fermi Large Area Telescope (LAT) has observed the star-forming region of Cygnus X. The 1- to 100-gigaelectronvolt images reveal a 50-parsec-wide cocoon of freshly accelerated cosmic rays that flood the cavities carved by the stellar winds and ionization fronts from young stellar clusters. It provides an example to study the youth of cosmic rays in a superbubble environment before they merge into the older Galactic population.
Wolf, T. J. A. ; Myhre, R. H. ; Cryan, J. P. ; Coriani, S. ; Squibb, R. J. ; Battistoni, A. ; Berrah, Nora ; Bostedt, Christoph ; Bucksbaum, Philip H. ; Coslovich, G. ; Feifel, R. ; Gaffney, K. J. ; Grilj, J. ; Martinez, T. J. ; Miyabe, S. ; Moeller, S. P. ; Mucke, M. ; Natan, A. ; Obaid, R. ; Osipov, T. ; Plekan, O. ; Wang, S. ; Koch, H. ; Guehr, Markus
Warrington, Nicole ; Beaumont, Robin ; Horikoshi, Momoko ; Day, Felix R. ; Helgeland, Øyvind ; Laurin, Charles ; Bacelis, Jonas ; Peng, Shouneng ; Hao, Ke ; Feenstra, Bjarke ; Wood, Andrew R. ; Mahajan, Anubha ; Tyrrell, Jessica ; Robertson, Neil R. ; Rayner, N. William ; Qiao, Zhen ; Moen, Gunn-Helen ; Vaudel, Marc ; Marsit, Carmen ; Chen, Jia ; Nodzenski, Michael ; Schnurr, Theresia M. ; Zafarmand, Mohammad Hadi ; Bradfield, Jonathan P. ; Grarup, Niels ; Kooijman, Marjolein N. ; Li-Gao, Ruifang ; Geller, Frank ; Ahluwalia, Tarunveer Singh ; Paternoster, Lavinia ; Rueedi, Rico ; Huikari, Ville ; Hottenga, Jouke-Jan ; Lyytikäinen, Leo-Pekka ; Cavadino, Alana ; Metrustry, Sarah ; Cousminer, Diana L. ; Wu, Ying ; Thiering, Elisabeth Paula ; Wang, Carol A. ; Have, Christian Theil ; Vilor-Tejedor, Natalia ; Joshi, Peter K. ; Painter, Jodie N. ; Ntalla, Ioanna ; Myhre, Ronny ; Pitkänen, Niina ; van Leeuwen, Elisabeth M. ; Joro, Raimo ; Lagou, Vasiliki ; Richmond, Rebecca C. ; Espinosa, Ana ; Barton, Sheila J. ; Inskip, Hazel M. ; Holloway, John W. ; Santa-Marina, Loreto ; Estivill, Xavier ; Ang, Wei ; Marsh, Julie A. ; Reichetzeder, Christoph ; Marullo, Letizia ; Hocher, Berthold ; Lunetta, Kathryn L. ; Murabito, Joanne M. ; Relton, Caroline L. ; Kogevinas, Manolis ; Chatzi, Leda ; Allard, Catherine ; Bouchard, Luigi ; Hivert, Marie-France ; Zhang, Ge ; Muglia, Louis J. ; Heikkinen, Jani ; Morgen, Camilla S. ; van Kampen, Antoine H. C. ; van Schaik, Barbera D. C. ; Mentch, Frank D. ; Langenberg, Claudia ; Scott, Robert A. ; Zhao, Jing Hua ; Hemani, Gibran ; Ring, Susan M. ; Bennett, Amanda J. ; Gaulton, Kyle J. ; Fernandez-Tajes, Juan ; van Zuydam, Natalie R. ; Medina-Gomez, Carolina ; de Haan, Hugoline G. ; Rosendaal, Frits R. ; Kutalik, Zoltán ; Marques-Vidal, Pedro ; Das, Shikta ; Willemsen, Gonneke ; Mbarek, Hamdi ; Müller-Nurasyid, Martina ; Standl, Marie ; Appel, Emil V. R. ; Fonvig, Cilius Esmann ; Trier, Caecilie ; van Beijsterveldt, Catharina E. M. ; Murcia, Mario ; Bustamante, Mariona ; Bonàs-Guarch, Sílvia ; Hougaard, David M. ; Mercader, Josep M. ; Linneberg, Allan ; Schraut, Katharina E. ; Lind, Penelope A. ; Medland, Sarah Elizabeth ; Shields, Beverley M. ; Knight, Bridget A. ; Chai, Jin-Fang ; Panoutsopoulou, Kalliope ; Bartels, Meike ; Sánchez, Friman ; Stokholm, Jakob ; Torrents, David ; Vinding, Rebecca K. ; Willems, Sara M. ; Atalay, Mustafa ; Chawes, Bo L. ; Kovacs, Peter ; Prokopenko, Inga ; Tuke, Marcus A. ; Yaghootkar, Hanieh ; Ruth, Katherine S. ; Jones, Samuel E. ; Loh, Po-Ru ; Murray, Anna ; Weedon, Michael N. ; Tönjes, Anke ; Stumvoll, Michael ; Michaelsen, Kim Fleischer ; Eloranta, Aino-Maija ; Lakka, Timo A. ; van Duijn, Cornelia M. ; Kiess, Wieland ; Koerner, Antje ; Niinikoski, Harri ; Pahkala, Katja ; Raitakari, Olli T. ; Jacobsson, Bo ; Zeggini, Eleftheria ; Dedoussis, George V. ; Teo, Yik-Ying ; Saw, Seang-Mei ; Montgomery, Grant W. ; Campbell, Harry ; Wilson, James F. ; Vrijkotte, Tanja G. M. ; Vrijheid, Martine ; de Geus, Eco J. C. N. ; Hayes, M. Geoffrey ; Kadarmideen, Haja N. ; Holm, Jens-Christian ; Beilin, Lawrence J. ; Pennell, Craig E. ; Heinrich, Joachim ; Adair, Linda S. ; Borja, Judith B. ; Mohlke, Karen L. ; Eriksson, Johan G. ; Widen, Elisabeth E. ; Hattersley, Andrew T. ; Spector, Tim D. ; Kaehoenen, Mika ; Viikari, Jorma S. ; Lehtimaeki, Terho ; Boomsma, Dorret I. ; Sebert, Sylvain ; Vollenweider, Peter ; Sorensen, Thorkild I. A. ; Bisgaard, Hans ; Bonnelykke, Klaus ; Murray, Jeffrey C. ; Melbye, Mads ; Nohr, Ellen A. ; Mook-Kanamori, Dennis O. ; Rivadeneira, Fernando ; Hofman, Albert ; Felix, Janine F. ; Jaddoe, Vincent W. V. ; Hansen, Torben ; Pisinger, Charlotta ; Vaag, Allan A. ; Pedersen, Oluf ; Uitterlinden, Andre G. ; Jarvelin, Marjo-Riitta ; Power, Christine ; Hypponen, Elina ; Scholtens, Denise M. ; Lowe, William L. ; Smith, George Davey ; Timpson, Nicholas J. ; Morris, Andrew P. ; Wareham, Nicholas J. ; Hakonarson, Hakon ; Grant, Struan F. A. ; Frayling, Timothy M. ; Lawlor, Debbie A. ; Njolstad, Pal R. ; Johansson, Stefan ; Ong, Ken K. ; McCarthy, Mark I. ; Perry, John R. B. ; Evans, David M. ; Freathy, Rachel M.
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.
Ijiri, Akira ; Inagaki, Fumio ; Kubo, Yusuke ; Adhikari, Rishi Ram ; Hattori, Shohei ; Hoshino, Tatsuhiko ; Imachi, Hiroyuki ; Kawagucci, Shinsuke ; Morono, Yuki ; Ohtomo, Yoko ; Ono, Shuhei ; Sakai, Sanae ; Takai, Ken ; Toki, Tomohiro ; Wang, David T. ; Yoshinaga, Marcos Y. ; Arnold, Gail L. ; Ashi, Juichiro ; Case, David H. ; Feseker, Tomas ; Hinrichs, Kai-Uwe ; Ikegawa, Yojiro ; Ikehara, Minoru ; Kallmeyer, Jens ; Kumagai, Hidenori ; Lever, Mark Alexander ; Morita, Sumito ; Nakamura, Ko-ichi ; Nakamura, Yuki ; Nishizawa, Manabu ; Orphan, Victoria J. ; Roy, Hans ; Schmidt, Frauke ; Tani, Atsushi ; Tanikawa, Wataru ; Terada, Takeshi ; Tomaru, Hitoshi ; Tsuji, Takeshi ; Tsunogai, Urumu ; Yamaguchi, Yasuhiko T. ; Yoshida, Naohiro
Dengler, Jürgen ; Wagner, Viktoria ; Dembicz, Iwona ; Garcia-Mijangos, Itziar ; Naqinezhad, Alireza ; Boch, Steffen ; Chiarucci, Alessandro ; Conradi, Timo ; Filibeck, Goffredo ; Guarino, Riccardo ; Janisova, Monika ; Steinbauer, Manuel J. ; Acic, Svetlana ; Acosta, Alicia T. R. ; Akasaka, Munemitsu ; Allers, Marc-Andre ; Apostolova, Iva ; Axmanova, Irena ; Bakan, Branko ; Baranova, Alina ; Bardy-Durchhalter, Manfred ; Bartha, Sandor ; Baumann, Esther ; Becker, Thomas ; Becker, Ute ; Belonovskaya, Elena ; Bengtsson, Karin ; Benito Alonso, Jose Luis ; Berastegi, Asun ; Bergamini, Ariel ; Bonini, Ilaria ; Bruun, Hans Henrik ; Budzhak, Vasyl ; Bueno, Alvaro ; Antonio Campos, Juan ; Cancellieri, Laura ; Carboni, Marta ; Chocarro, Cristina ; Conti, Luisa ; Czarniecka-Wiera, Marta ; De Frenne, Pieter ; Deak, Balazs ; Didukh, Yakiv P. ; Diekmann, Martin ; Dolnik, Christian ; Dupre, Cecilia ; Ecker, Klaus ; Ermakov, Nikolai ; Erschbamer, Brigitta ; Escudero, Adrian ; Etayo, Javier ; Fajmonova, Zuzana ; Felde, Vivian A. ; Fernandez Calzado, Maria Rosa ; Finckh, Manfred ; Fotiadis, Georgios ; Fracchiolla, Mariano ; Ganeva, Anna ; Garcia-Magro, Daniel ; Gavilan, Rosario G. ; Germany, Markus ; Giladi, Itamar ; Gillet, Francois ; Giusso del Galdo, Gian Pietro ; Gonzalez, Jose M. ; Grytnes, John-Arvid ; Hajek, Michal ; Hajkova, Petra ; Helm, Aveliina ; Herrera, Mercedes ; Hettenbergerova, Eva ; Hobohm, Carsten ; Huellbusch, Elisabeth M. ; Ingerpuu, Nele ; Jandt, Ute ; Jeltsch, Florian ; Jensen, Kai ; Jentsch, Anke ; Jeschke, Michael ; Jimenez-Alfaro, Borja ; Kacki, Zygmunt ; Kakinuma, Kaoru ; Kapfer, Jutta ; Kavgaci, Ali ; Kelemen, Andras ; Kiehl, Kathrin ; Koyama, Asuka ; Koyanagi, Tomoyo F. ; Kozub, Lukasz ; Kuzemko, Anna ; Kyrkjeeide, Magni Olsen ; Landi, Sara ; Langer, Nancy ; Lastrucci, Lorenzo ; Lazzaro, Lorenzo ; Lelli, Chiara ; Leps, Jan ; Loebel, Swantje ; Luzuriaga, Arantzazu L. ; Maccherini, Simona ; Magnes, Martin ; Malicki, Marek ; Marceno, Corrado ; Mardari, Constantin ; Mauchamp, Leslie ; May, Felix ; Michelsen, Ottar ; Mesa, Joaquin Molero ; Molnar, Zsolt ; Moysiyenko, Ivan Y. ; Nakaga, Yuko K. ; Natcheva, Rayna ; Noroozi, Jalil ; Pakeman, Robin J. ; Palpurina, Salza ; Partel, Meelis ; Paetsch, Ricarda ; Pauli, Harald ; Pedashenko, Hristo ; Peet, Robert K. ; Pielech, Remigiusz ; Pipenbaher, Natasa ; Pirini, Chrisoula ; Pleskova, Zuzana ; Polyakova, Mariya A. ; Prentice, Honor C. ; Reinecke, Jennifer ; Reitalu, Triin ; Pilar Rodriguez-Rojo, Maria ; Rolecek, Jan ; Ronkin, Vladimir ; Rosati, Leonardo ; Rosen, Ejvind ; Ruprecht, Eszter ; Rusina, Solvita ; Sabovljevic, Marko ; Maria Sanchez, Ana ; Savchenko, Galina ; Schuhmacher, Oliver ; Skornik, Sonja ; Sperandii, Marta Gaia ; Staniaszek-Kik, Monika ; Stevanovic-Dajic, Zora ; Stock, Marin ; Suchrow, Sigrid ; Sutcliffe, Laura M. E. ; Swacha, Grzegorz ; Sykes, Martin ; Szabo, Anna ; Talebi, Amir ; Tanase, Catalin ; Terzi, Massimo ; Tolgyesi, Csaba ; Torca, Marta ; Torok, Peter ; Tothmeresz, Bela ; Tsarevskaya, Nadezda ; Tsiripidis, Ioannis ; Tzonev, Rossen ; Ushimaru, Atushi ; Valko, Orsolya ; van der Maarel, Eddy ; Vanneste, Thomas ; Vashenyak, Iuliia ; Vassilev, Kiril ; Viciani, Daniele ; Villar, Luis ; Virtanen, Risto ; Kosic, Ivana Vitasovic ; Wang, Yun ; Weiser, Frank ; Went, Julia ; Wesche, Karsten ; White, Hannah ; Winkler, Manuela ; Zaniewski, Piotr T. ; Zhang, Hui ; Ziv, Yaron ; Znamenskiy, Sergey ; Biurrun, Idoia
GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). GrassPlot collects plot records (releves) from grasslands and other open habitats of the Palaearctic biogeographic realm. It focuses on precisely delimited plots of eight standard grain sizes (0.0001; 0.001;... 1,000 m(2)) and on nested-plot series with at least four different grain sizes. The usage of GrassPlot is regulated through Bylaws that intend to balance the interests of data contributors and data users. The current version (v. 1.00) contains data for approximately 170,000 plots of different sizes and 2,800 nested-plot series. The key components are richness data and metadata. However, most included datasets also encompass compositional data. About 14,000 plots have near-complete records of terricolous bryophytes and lichens in addition to vascular plants. At present, GrassPlot contains data from 36 countries throughout the Palaearctic, spread across elevational gradients and major grassland types. GrassPlot with its multi-scale and multi-taxon focus complements the larger international vegetationplot databases, such as the European Vegetation Archive (EVA) and the global database " sPlot". Its main aim is to facilitate studies on the scale-and taxon-dependency of biodiversity patterns and drivers along macroecological gradients. GrassPlot is a dynamic database and will expand through new data collection coordinated by the elected Governing Board. We invite researchers with suitable data to join GrassPlot. Researchers with project ideas addressable with GrassPlot data are welcome to submit proposals to the Governing Board.
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
(2019)
Middeldorp, Christel M. ; Mahajan, Anubha ; Horikoshi, Momoko ; Robertson, Neil R. ; Beaumont, Robin N. ; Bradfield, Jonathan P. ; Bustamante, Mariona ; Cousminer, Diana L. ; Day, Felix R. ; De Silva, N. Maneka ; Guxens, Monica ; Mook-Kanamori, Dennis O. ; St Pourcain, Beate ; Warrington, Nicole M. ; Adair, Linda S. ; Ahlqvist, Emma ; Ahluwalia, Tarunveer Singh ; Almgren, Peter ; Ang, Wei ; Atalay, Mustafa ; Auvinen, Juha ; Bartels, Meike ; Beckmann, Jacques S. ; Bilbao, Jose Ramon ; Bond, Tom ; Borja, Judith B. ; Cavadino, Alana ; Charoen, Pimphen ; Chen, Zhanghua ; Coin, Lachlan ; Cooper, Cyrus ; Curtin, John A. ; Custovic, Adnan ; Das, Shikta ; Davies, Gareth E. ; Dedoussis, George V. ; Duijts, Liesbeth ; Eastwood, Peter R. ; Eliasen, Anders U. ; Elliott, Paul ; Eriksson, Johan G. ; Estivill, Xavier ; Fadista, Joao ; Fedko, Iryna O. ; Frayling, Timothy M. ; Gaillard, Romy ; Gauderman, W. James ; Geller, Frank ; Gilliland, Frank ; Gilsanz, Vincente ; Granell, Raquel ; Grarup, Niels ; Groop, Leif ; Hadley, Dexter ; Hakonarson, Hakon ; Hansen, Torben ; Hartman, Catharina A. ; Hattersley, Andrew T. ; Hayes, M. Geoffrey ; Hebebrand, Johannes ; Heinrich, Joachim ; Helgeland, Oyvind ; Henders, Anjali K. ; Henderson, John ; Henriksen, Tine B. ; Hirschhorn, Joel N. ; Hivert, Marie-France ; Hocher, Berthold ; Holloway, John W. ; Holt, Patrick ; Hottenga, Jouke-Jan ; Hypponen, Elina ; Iniguez, Carmen ; Johansson, Stefan ; Jugessur, Astanand ; Kahonen, Mika ; Kalkwarf, Heidi J. ; Kaprio, Jaakko ; Karhunen, Ville ; Kemp, John P. ; Kerkhof, Marjan ; Koppelman, Gerard H. ; Korner, Antje ; Kotecha, Sailesh ; Kreiner-Moller, Eskil ; Kulohoma, Benard ; Kumar, Ashish ; Kutalik, Zoltan ; Lahti, Jari ; Lappe, Joan M. ; Larsson, Henrik ; Lehtimaki, Terho ; Lewin, Alexandra M. ; Li, Jin ; Lichtenstein, Paul ; Lindgren, Cecilia M. ; Lindi, Virpi ; Linneberg, Allan ; Liu, Xueping ; Liu, Jun ; Lowe, William L. ; Lundstrom, Sebastian ; Lyytikainen, Leo-Pekka ; Ma, Ronald C. W. ; Mace, Aurelien ; Magi, Reedik ; Magnus, Per ; Mamun, Abdullah A. ; Mannikko, Minna ; Martin, Nicholas G. ; Mbarek, Hamdi ; McCarthy, Nina S. ; Medland, Sarah E. ; Melbye, Mads ; Melen, Erik ; Mohlke, Karen L. ; Monnereau, Claire ; Morgen, Camilla S. ; Morris, Andrew P. ; Murray, Jeffrey C. ; Myhre, Ronny ; Najman, Jackob M. ; Nivard, Michel G. ; Nohr, Ellen A. ; Nolte, Ilja M. ; Ntalla, Ioanna ; Oberfield, Sharon E. ; Oken, Emily ; Oldehinkel, Albertine J. ; Pahkala, Katja ; Palviainen, Teemu ; Panoutsopoulou, Kalliope ; Pedersen, Oluf ; Pennell, Craig E. ; Pershagen, Goran ; Pitkanen, Niina ; Plomin, Robert ; Power, Christine ; Prasad, Rashmi B. ; Prokopenko, Inga ; Pulkkinen, Lea ; Raikkonen, Katri ; Raitakari, Olli T. ; Reynolds, Rebecca M. ; Richmond, Rebecca C. ; Rivadeneira, Fernando ; Rodriguez, Alina ; Rose, Richard J. ; Salem, Rany ; Santa-Marina, Loreto ; Saw, Seang-Mei ; Schnurr, Theresia M. ; Scott, James G. ; Selzam, Saskia ; Shepherd, John A. ; Simpson, Angela ; Skotte, Line ; Sleiman, Patrick M. A. ; Snieder, Harold ; Sorensen, Thorkild I. A. ; Standl, Marie ; Steegers, Eric A. P. ; Strachan, David P. ; Straker, Leon ; Strandberg, Timo ; Taylor, Michelle ; Teo, Yik-Ying ; Thiering, Elisabeth ; Torrent, Maties ; Tyrrell, Jessica ; Uitterlinden, Andre G. ; van Beijsterveldt, Toos ; van der Most, Peter J. ; van Duijn, Cornelia M. ; Viikari, Jorma ; Vilor-Tejedor, Natalia ; Vogelezang, Suzanne ; Vonk, Judith M. ; Vrijkotte, Tanja G. M. ; Vuoksimaa, Eero ; Wang, Carol A. ; Watkins, William J. ; Wichmann, H-Erich ; Willemsen, Gonneke ; Williams, Gail M. ; Wilson, James F. ; Wray, Naomi R. ; Xu, Shujing ; Xu, Cheng-Jian ; Yaghootkar, Hanieh ; Yi, Lu ; Zafarmand, Mohammad Hadi ; Zeggini, Eleftheria ; Zemel, Babette S. ; Hinney, Anke ; Lakka, Timo A. ; Whitehouse, Andrew J. O. ; Sunyer, Jordi ; Widen, Elisabeth E. ; Feenstra, Bjarke ; Sebert, Sylvain ; Jacobsson, Bo ; Njolstad, Pal R. ; Stoltenberg, Camilla ; Smith, George Davey ; Lawlor, Debbie A. ; Paternoster, Lavinia ; Timpson, Nicholas J. ; Ong, Ken K. ; Bisgaard, Hans ; Bonnelykke, Klaus ; Jaddoe, Vincent W. V. ; Tiemeier, Henning ; Jarvelin, Marjo-Riitta ; Evans, David M. ; Perry, John R. B. ; Grant, Struan F. A. ; Boomsma, Dorret I. ; Freathy, Rachel M. ; McCarthy, Mark I. ; Felix, Janine F.
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
Ijiri, Akira ; Inagaki, Fumio ; Kubo, Yusuke ; Adhikari, Rishi Ram ; Hattori, Shohei ; Hoshino, Tatsuhiko ; Imachi, Hiroyuki ; Kawagucci, Shinsuke ; Morono, Yuki ; Ohtomo, Yoko ; Ono, Shuhei ; Sakai, Sanae ; Takai, Ken ; Toki, Tomohiro ; Wang, David T. ; Yoshinaga, Marcos Y. ; Arnold, Gail L. ; Ashi, Juichiro ; Case, David H. ; Feseker, Tomas ; Hinrichs, Kai-Uwe ; Ikegawa, Yojiro ; Ikehara, Minoru ; Kallmeyer, Jens ; Kumagai, Hidenori ; Lever, Mark Alexander ; Morita, Sumito ; Nakamura, Ko-ichi ; Nakamura, Yuki ; Nishizawa, Manabu ; Orphan, Victoria J. ; Røy, Hans ; Schmidt, Frauke ; Tani, Atsushi ; Tanikawa, Wataru ; Terada, Takeshi ; Tomaru, Hitoshi ; Tsuji, Takeshi ; Tsunogai, Urumu ; Yamaguchi, Yasuhiko T. ; Yoshida, Naohiro
Microbial life inhabiting subseafloor sediments plays an important role in Earth’s carbon cycle. However, the impact of geodynamic processes on the distributions and carbon-cycling activities of subseafloor life remains poorly constrained. We explore a submarine mud volcano of the Nankai accretionary complex by drilling down to 200 m below the summit. Stable isotopic compositions of water and carbon compounds, including clumped methane isotopologues, suggest that ~90% of methane is microbially produced at 16° to 30°C and 300 to 900 m below seafloor, corresponding to the basin bottom, where fluids in the accretionary prism are supplied via megasplay faults. Radiotracer experiments showed that relatively small microbial populations in deep mud volcano sediments (10 2 to 10 3 cells cm −3 ) include highly active hydrogenotrophic methanogens and acetogens. Our findings indicate that subduction-associated fluid migration has stimulated microbial activity in the mud reservoir and that mud volcanoes may contribute more substantially to the methane budget than previously estimated.
Le Friant, A. ; Ishizuka, O. ; Boudon, G. ; Palmer, M. R. ; Talling, P. J. ; Villemant, B. ; Adachi, T. ; Aljahdali, M. ; Breitkreuz, C. ; Brunet, M. ; Caron, B. ; Coussens, M. ; Deplus, C. ; Endo, D. ; Feuillet, N. ; Fraas, A. J. ; Fujinawa, A. ; Hart, M. B. ; Hatfield, R. G. ; Hornbach, M. ; Jutzeler, M. ; Kataoka, K. S. ; Komorowski, J. -C. ; Lebas, E. ; Lafuerza, S. ; Maeno, F. ; Manga, M. ; Martinez-Colon, M. ; McCanta, M. ; Morgan, S. ; Saito, T. ; Slagle, A. ; Sparks, S. ; Stinton, A. ; Stroncik, Nicole ; Subramanyam, K. S. V. ; Tamura, Yui ; Trofimovs, J. ; Voight, B. ; Wall-Palmer, D. ; Wang, F. ; Watt, S. F. L.
IODP Expedition 340 successfully drilled a series of sites offshore Montserrat, Martinique and Dominica in the Lesser Antilles from March to April 2012. These are among the few drill sites gathered around volcanic islands, and the first scientific drilling of large and likely tsunamigenic volcanic island-arc landslide deposits. These cores provide evidence and tests of previous hypotheses for the composition and origin of those deposits. Sites U1394, U1399, and U1400 that penetrated landslide deposits recovered exclusively seafloor sediment, comprising mainly turbidites and hemipelagic deposits, and lacked debris avalanche deposits. This supports the concepts that i/ volcanic debris avalanches tend to stop at the slope break, and ii/ widespread and voluminous failures of preexisting low-gradient seafloor sediment can be triggered by initial emplacement of material from the volcano. Offshore Martinique (U1399 and 1400), the landslide deposits comprised blocks of parallel strata that were tilted or microfaulted, sometimes separated by intervals of homogenized sediment (intense shearing), while Site U1394 offshore Montserrat penetrated a flat-lying block of intact strata. The most likely mechanism for generating these large-scale seafloor sediment failures appears to be propagation of a decollement from proximal areas loaded and incised by a volcanic debris avalanche. These results have implications for the magnitude of tsunami generation. Under some conditions, volcanic island landslide deposits composed of mainly seafloor sediment will tend to form smaller magnitude tsunamis than equivalent volumes of subaerial block-rich mass flows rapidly entering water. Expedition 340 also successfully drilled sites to access the undisturbed record of eruption fallout layers intercalated with marine sediment which provide an outstanding high-resolution data set to analyze eruption and landslides cycles, improve understanding of magmatic evolution as well as offshore sedimentation processes.
Russell, C. M. P. ; Corcoran, M. F. ; Cuadra, J. ; Owocki, S. P. ; Wang, Q. D. ; Hamaguchi, K. ; Sugawara, Y. ; Pollock, A. M. T. ; Kallman, T. R.
Colliding Wolf-Rayet (WR) winds produce thermal X-ray emission widely observed by X-ray telescopes. In wide WR+O binaries, such as WR 140, the X-ray flux is tied to the orbital phase, and is a direct probe of the winds’ properties. In the Galactic center, ~30 WRs orbit the super massive black hole (SMBH) within ~10”, leading to a smorgasbord of wind-wind collisions. To model the X-ray emission of WR 140 and the Galactic center, we perform 3D hydrodynamic simulations to trace the complex gaseous flows, and then carry out 3D radiative transfer calculations to compute the variable X-ray spectra. The model WR 140 RXTE light curve matches the data well for all phases except the X-ray minimum associated with periastron, while the model spectra agree with the RXTE hardness ratio and the shape of the Suzaku observations throughout the orbit. The Galactic center model of the Chandra flux and spectral shape match well in the region r ≤ 3”, but the model flux falls off too rapidly beyond this radius.
Gorski, Mathias ; Jung, Bettina ; Li, Yong ; Matias-Garcia, Pamela R. ; Wuttke, Matthias ; Coassin, Stefan ; Thio, Chris H. L. ; Kleber, Marcus E. ; Winkler, Thomas W. ; Wanner, Veronika ; Chai, Jin-Fang ; Chu, Audrey Y. ; Cocca, Massimiliano ; Feitosa, Mary F. ; Ghasemi, Sahar ; Hoppmann, Anselm ; Horn, Katrin ; Li, Man ; Nutile, Teresa ; Scholz, Markus ; Sieber, Karsten B. ; Teumer, Alexander ; Tin, Adrienne ; Wang, Judy ; Tayo, Bamidele O. ; Ahluwalia, Tarunveer S. ; Almgren, Peter ; Bakker, Stephan J. L. ; Banas, Bernhard ; Bansal, Nisha ; Biggs, Mary L. ; Boerwinkle, Eric ; Böttinger, Erwin ; Brenner, Hermann ; Carroll, Robert J. ; Chalmers, John ; Chee, Miao-Li ; Chee, Miao-Ling ; Cheng, Ching-Yu ; Coresh, Josef ; de Borst, Martin H. ; Degenhardt, Frauke ; Eckardt, Kai-Uwe ; Endlich, Karlhans ; Franke, Andre ; Freitag-Wolf, Sandra ; Gampawar, Piyush ; Gansevoort, Ron T. ; Ghanbari, Mohsen ; Gieger, Christian ; Hamet, Pavel ; Ho, Kevin ; Hofer, Edith ; Holleczek, Bernd ; Foo, Valencia Hui Xian ; Hutri-Kahonen, Nina ; Hwang, Shih-Jen ; Ikram, M. Arfan ; Josyula, Navya Shilpa ; Kahonen, Mika ; Khor, Chiea-Chuen ; Koenig, Wolfgang ; Kramer, Holly ; Kraemer, Bernhard K. ; Kuehnel, Brigitte ; Lange, Leslie A. ; Lehtimaki, Terho ; Lieb, Wolfgang ; Loos, Ruth J. F. ; Lukas, Mary Ann ; Lyytikainen, Leo-Pekka ; Meisinger, Christa ; Meitinger, Thomas ; Melander, Olle ; Milaneschi, Yuri ; Mishra, Pashupati P. ; Mononen, Nina ; Mychaleckyj, Josyf C. ; Nadkarni, Girish N. ; Nauck, Matthias ; Nikus, Kjell ; Ning, Boting ; Nolte, Ilja M. ; O'Donoghue, Michelle L. ; Orho-Melander, Marju ; Pendergrass, Sarah A. ; Penninx, Brenda W. J. H. ; Preuss, Michael H. ; Psaty, Bruce M. ; Raffield, Laura M. ; Raitakari, Olli T. ; Rettig, Rainer ; Rheinberger, Myriam ; Rice, Kenneth M. ; Rosenkranz, Alexander R. ; Rossing, Peter ; Rotter, Jerome ; Sabanayagam, Charumathi ; Schmidt, Helena ; Schmidt, Reinhold ; Schoettker, Ben ; Schulz, Christina-Alexandra ; Sedaghat, Sanaz ; Shaffer, Christian M. ; Strauch, Konstantin ; Szymczak, Silke ; Taylor, Kent D. ; Tremblay, Johanne ; Chaker, Layal ; van der Harst, Pim ; van der Most, Peter J. ; Verweij, Niek ; Voelker, Uwe ; Waldenberger, Melanie ; Wallentin, Lars ; Waterworth, Dawn M. ; White, Harvey D. ; Wilson, James G. ; Wong, Tien-Yin ; Woodward, Mark ; Yang, Qiong ; Yasuda, Masayuki ; Yerges-Armstrong, Laura M. ; Zhang, Yan ; Snieder, Harold ; Wanner, Christoph ; Boger, Carsten A. ; Kottgen, Anna ; Kronenberg, Florian ; Pattaro, Cristian ; Heid, Iris M.
Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
Gorski, Mathias ; Jung, Bettina ; Li, Yong ; Matias-Garcia, Pamela R. ; Wuttke, Matthias ; Coassin, Stefan ; Thio, Chris H. L. ; Kleber, Marcus E. ; Winkler, Thomas W. ; Wanner, Veronika ; Chai, Jin-Fang ; Chu, Audrey Y. ; Cocca, Massimiliano ; Feitosa, Mary F. ; Ghasemi, Sahar ; Hoppmann, Anselm ; Horn, Katrin ; Li, Man ; Nutile, Teresa ; Scholz, Markus ; Sieber, Karsten B. ; Teumer, Alexander ; Tin, Adrienne ; Wang, Judy ; Tayo, Bamidele O. ; Ahluwalia, Tarunveer S. ; Almgren, Peter ; Bakker, Stephan J. L. ; Banas, Bernhard ; Bansal, Nisha ; Biggs, Mary L. ; Boerwinkle, Eric ; Böttinger, Erwin ; Brenner, Hermann ; Carroll, Robert J. ; Chalmers, John ; Chee, Miao-Li ; Chee, Miao-Ling ; Cheng, Ching-Yu ; Coresh, Josef ; de Borst, Martin H. ; Degenhardt, Frauke ; Eckardt, Kai-Uwe ; Endlich, Karlhans ; Franke, Andre ; Freitag-Wolf, Sandra ; Gampawar, Piyush ; Gansevoort, Ron T. ; Ghanbari, Mohsen ; Gieger, Christian ; Hamet, Pavel ; Ho, Kevin ; Hofer, Edith ; Holleczek, Bernd ; Foo, Valencia Hui Xian ; Hutri-Kahonen, Nina ; Hwang, Shih-Jen ; Ikram, M. Arfan ; Josyula, Navya Shilpa ; Kahonen, Mika ; Khor, Chiea-Chuen ; Koenig, Wolfgang ; Kramer, Holly ; Kraemer, Bernhard K. ; Kuehnel, Brigitte ; Lange, Leslie A. ; Lehtimaki, Terho ; Lieb, Wolfgang ; Loos, Ruth J. F. ; Lukas, Mary Ann ; Lyytikainen, Leo-Pekka ; Meisinger, Christa ; Meitinger, Thomas ; Melander, Olle ; Milaneschi, Yuri ; Mishra, Pashupati P. ; Mononen, Nina ; Mychaleckyj, Josyf C. ; Nadkarni, Girish N. ; Nauck, Matthias ; Nikus, Kjell ; Ning, Boting ; Nolte, Ilja M. ; O'Donoghue, Michelle L. ; Orho-Melander, Marju ; Pendergrass, Sarah A. ; Penninx, Brenda W. J. H. ; Preuss, Michael H. ; Psaty, Bruce M. ; Raffield, Laura M. ; Raitakari, Olli T. ; Rettig, Rainer ; Rheinberger, Myriam ; Rice, Kenneth M. ; Rosenkranz, Alexander R. ; Rossing, Peter ; Rotter, Jerome ; Sabanayagam, Charumathi ; Schmidt, Helena ; Schmidt, Reinhold ; Schoettker, Ben ; Schulz, Christina-Alexandra ; Sedaghat, Sanaz ; Shaffer, Christian M. ; Strauch, Konstantin ; Szymczak, Silke ; Taylor, Kent D. ; Tremblay, Johanne ; Chaker, Layal ; van der Harst, Pim ; van der Most, Peter J. ; Verweij, Niek ; Voelker, Uwe ; Waldenberger, Melanie ; Wallentin, Lars ; Waterworth, Dawn M. ; White, Harvey D. ; Wilson, James G. ; Wong, Tien-Yin ; Woodward, Mark ; Yang, Qiong ; Yasuda, Masayuki ; Yerges-Armstrong, Laura M. ; Zhang, Yan ; Snieder, Harold ; Wanner, Christoph ; Boger, Carsten A. ; Kottgen, Anna ; Kronenberg, Florian ; Pattaro, Cristian ; Heid, Iris M.
Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
Tiegs, Scott D. ; Costello, David M. ; Isken, Mark W. ; Woodward, Guy ; McIntyre, Peter B. ; Gessner, Mark O. ; Chauvet, Eric ; Griffiths, Natalie A. ; Flecker, Alex S. ; Acuna, Vicenc ; Albarino, Ricardo ; Allen, Daniel C. ; Alonso, Cecilia ; Andino, Patricio ; Arango, Clay ; Aroviita, Jukka ; Barbosa, Marcus V. M. ; Barmuta, Leon A. ; Baxter, Colden V. ; Bell, Thomas D. C. ; Bellinger, Brent ; Boyero, Luz ; Brown, Lee E. ; Bruder, Andreas ; Bruesewitz, Denise A. ; Burdon, Francis J. ; Callisto, Marcos ; Canhoto, Cristina ; Capps, Krista A. ; Castillo, Maria M. ; Clapcott, Joanne ; Colas, Fanny ; Colon-Gaud, Checo ; Cornut, Julien ; Crespo-Perez, Veronica ; Cross, Wyatt F. ; Culp, Joseph M. ; Danger, Michael ; Dangles, Olivier ; de Eyto, Elvira ; Derry, Alison M. ; Diaz Villanueva, Veronica ; Douglas, Michael M. ; Elosegi, Arturo ; Encalada, Andrea C. ; Entrekin, Sally ; Espinosa, Rodrigo ; Ethaiya, Diana ; Ferreira, Veronica ; Ferriol, Carmen ; Flanagan, Kyla M. ; Fleituch, Tadeusz ; Shah, Jennifer J. Follstad ; Frainer, Andre ; Friberg, Nikolai ; Frost, Paul C. ; Garcia, Erica A. ; Lago, Liliana Garcia ; Garcia Soto, Pavel Ernesto ; Ghate, Sudeep ; Giling, Darren P. ; Gilmer, Alan ; Goncalves, Jose Francisco ; Gonzales, Rosario Karina ; Graca, Manuel A. S. ; Grace, Mike ; Grossart, Hans-Peter ; Guerold, Francois ; Gulis, Vlad ; Hepp, Luiz U. ; Higgins, Scott ; Hishi, Takuo ; Huddart, Joseph ; Hudson, John ; Imberger, Samantha ; Iniguez-Armijos, Carlos ; Iwata, Tomoya ; Janetski, David J. ; Jennings, Eleanor ; Kirkwood, Andrea E. ; Koning, Aaron A. ; Kosten, Sarian ; Kuehn, Kevin A. ; Laudon, Hjalmar ; Leavitt, Peter R. ; Lemes da Silva, Aurea L. ; Leroux, Shawn J. ; Leroy, Carri J. ; Lisi, Peter J. ; MacKenzie, Richard ; Marcarelli, Amy M. ; Masese, Frank O. ; Mckie, Brendan G. ; Oliveira Medeiros, Adriana ; Meissner, Kristian ; Milisa, Marko ; Mishra, Shailendra ; Miyake, Yo ; Moerke, Ashley ; Mombrikotb, Shorok ; Mooney, Rob ; Moulton, Tim ; Muotka, Timo ; Negishi, Junjiro N. ; Neres-Lima, Vinicius ; Nieminen, Mika L. ; Nimptsch, Jorge ; Ondruch, Jakub ; Paavola, Riku ; Pardo, Isabel ; Patrick, Christopher J. ; Peeters, Edwin T. H. M. ; Pozo, Jesus ; Pringle, Catherine ; Prussian, Aaron ; Quenta, Estefania ; Quesada, Antonio ; Reid, Brian ; Richardson, John S. ; Rigosi, Anna ; Rincon, Jose ; Risnoveanu, Geta ; Robinson, Christopher T. ; Rodriguez-Gallego, Lorena ; Royer, Todd V. ; Rusak, James A. ; Santamans, Anna C. ; Selmeczy, Geza B. ; Simiyu, Gelas ; Skuja, Agnija ; Smykla, Jerzy ; Sridhar, Kandikere R. ; Sponseller, Ryan ; Stoler, Aaron ; Swan, Christopher M. ; Szlag, David ; Teixeira-de Mello, Franco ; Tonkin, Jonathan D. ; Uusheimo, Sari ; Veach, Allison M. ; Vilbaste, Sirje ; Vought, Lena B. M. ; Wang, Chiao-Ping ; Webster, Jackson R. ; Wilson, Paul B. ; Woelfl, Stefan ; Xenopoulos, Marguerite A. ; Yates, Adam G. ; Yoshimura, Chihiro ; Yule, Catherine M. ; Zhang, Yixin X. ; Zwart, Jacob A.
River ecosystems receive and process vast quantities of terrestrial organic carbon, the fate of which depends strongly on microbial activity. Variation in and controls of processing rates, however, are poorly characterized at the global scale. In response, we used a peer-sourced research network and a highly standardized carbon processing assay to conduct a global-scale field experiment in greater than 1000 river and riparian sites. We found that Earth’s biomes have distinct carbon processing signatures. Slow processing is evident across latitudes, whereas rapid rates are restricted to lower latitudes. Both the mean rate and variability decline with latitude, suggesting temperature constraints toward the poles and greater roles for other environmental drivers (e.g., nutrient loading) toward the equator. These results and data set the stage for unprecedented “next-generation biomonitoring” by establishing baselines to help quantify environmental impacts to the functioning of ecosystems at a global scale.
Preferred well-founded semantics for logic programming by alternating fixpoints : preliminary report
(2002)
Hodgkins, Suzanne B. ; Richardson, Curtis J. ; Dommain, René ; Wang, Hongjun ; Glaser, Paul H. ; Verbeke, Brittany ; Winkler, B. Rose ; Cobb, Alexander R. ; Rich, Virginia I. ; Missilmani, Malak ; Flanagan, Neal ; Ho, Mengchi ; Hoyt, Alison M. ; Harvey, Charles F. ; Vining, S. Rose ; Hough, Moira A. ; Moore, Tim R. ; Richard, Pierre J. H. ; De La Cruz, Florentino B. ; Toufaily, Joumana ; Hamdan, Rasha ; Cooper, William T. ; Chanton, Jeffrey P.
Peatlands represent large terrestrial carbon banks. Given that most peat accumulates in boreal regions, where low temperatures and water saturation preserve organic matter, the existence of peat in (sub)tropical regions remains enigmatic. Here we examined peat and plant chemistry across a latitudinal transect from the Arctic to the tropics. Near-surface low-latitude peat has lower carbohydrate and greater aromatic content than near-surface high-latitude peat, creating a reduced oxidation state and resulting recalcitrance. This recalcitrance allows peat to persist in the (sub)tropics despite warm temperatures. Because we observed similar declines in carbohydrate content with depth in high-latitude peat, our data explain recent field-scale deep peat warming experiments in which catotelm (deeper) peat remained stable despite temperature increases up to 9 degrees C. We suggest that high-latitude deep peat reservoirs may be stabilized in the face of climate change by their ultimately lower carbohydrate and higher aromatic composition, similar to tropical peats.
Hodgkins, Suzanne B. ; Richardson, Curtis J. ; Dommain, Rene ; Wang, Hongjun ; Glaser, Paul H. ; Verbeke, Brittany ; Winkler, B. Rose ; Cobb, Alexander R. ; Rich, Virginia I. ; Missilmani, Malak ; Flanagan, Neal ; Ho, Mengchi ; Hoyt, Alison M. ; Harvey, Charles F. ; Vining, S. Rose ; Hough, Moira A. ; Moore, Tim R. ; Richard, Pierre J. H. ; De la Cruz, Florentino B. ; Toufaily, Joumana ; Hamdan, Rasha ; Cooper, William T. ; Chanton, Jeffrey P.
Peatlands represent large terrestrial carbon banks. Given that most peat accumulates in boreal regions, where low temperatures and water saturation preserve organic matter, the existence of peat in (sub)tropical regions remains enigmatic. Here we examined peat and plant chemistry across a latitudinal transect from the Arctic to the tropics. Near-surface low-latitude peat has lower carbohydrate and greater aromatic content than near-surface high-latitude peat, creating a reduced oxidation state and resulting recalcitrance. This recalcitrance allows peat to persist in the (sub)tropics despite warm temperatures. Because we observed similar declines in carbohydrate content with depth in high-latitude peat, our data explain recent field-scale deep peat warming experiments in which catotelm (deeper) peat remained stable despite temperature increases up to 9 degrees C. We suggest that high-latitude deep peat reservoirs may be stabilized in the face of climate change by their ultimately lower carbohydrate and higher aromatic composition, similar to tropical peats.
The photochemical ring-opening of 1,3-cyclohexadiene imaged by ultrafast electron diffraction
(2019)
Wolf, Thomas J. A. ; Sanchez, David M. ; Yang, J. ; Parrish, R. M. ; Nunes, J. P. F. ; Centurion, M. ; Coffee, R. ; Cryan, J. P. ; Gühr, Markus ; Hegazy, Kareem ; Kirrander, Adam ; Li, R. K. ; Ruddock, J. ; Shen, Xiaozhe ; Vecchione, T. ; Weathersby, S. P. ; Weber, Peter M. ; Wilkin, K. ; Yong, Haiwang ; Zheng, Q. ; Wang, X. J. ; Minitti, Michael P. ; Martinez, Todd J.
The ultrafast photoinduced ring-opening of 1,3-cyclohexadiene constitutes a textbook example of electrocyclic reactions in organic chemistry and a model for photobiological reactions in vitamin D synthesis. Although the relaxation from the photoexcited electronic state during the ring-opening has been investigated in numerous studies, the accompanying changes in atomic distance have not been resolved. Here we present a direct and unambiguous observation of the ring-opening reaction path on the femtosecond timescale and subangstrom length scale using megaelectronvolt ultrafast electron diffraction. We followed the carbon-carbon bond dissociation and the structural opening of the 1,3-cyclohexadiene ring by the direct measurement of time-dependent changes in the distribution of interatomic distances. We observed a substantial acceleration of the ring-opening motion after internal conversion to the ground state due to a steepening of the electronic potential gradient towards the product minima. The ring-opening motion transforms into rotation of the terminal ethylene groups in the photoproduct 1,3,5-hexatriene on the subpicosecond timescale.