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Feld, Christian ; Mechie, James ; Hübscher, Christian ; Hall, Jeremy ; Nicolaides, Stelios ; Gurbuz, Cemil ; Bauer, Klaus ; Louden, Keith ; Weber, Michael
In 2010, project CoCoCo (incipient COntinent-COntinent COllision) recorded a 650 km long amphibian N-S wide-angle seismic profile, extending from the Anatolian plateau across southern Turkey and Cyprus to just south of the Eratosthenes Seamount (ESM). The aim of the project is to reveal the impact of the transition from subduction to continent-continent collision of Africa with Anatolia. Arrival picking, finite-differences ray-tracing and inversion of the offshore and on-offshore data produced a tomographic model across southern Cyprus, the accretionary wedge and the ESM. The main features of this model are (1) crustal P-velocities predominantly lower than 6.5 km/s beneath the ESM, (2) crustal thickness between 28 and 37 km, (3) an upper crustal reflection at 5 km depth beneath the ESM, (4) the likely presence of oceanic crust south of the ESM and a transform margin north of it and (5) a 12 km thick ophiolite sequence on Cyprus. Land shots on Turkey, also recorded on Cyprus, gravity data and geological and previous seismic investigations allow to derive a layered velocity model beneath Anatolia and the northern part of Cyprus. The main features of this model are (1) Moho depths of 38–45 km beneath the Anatolian plateau, (2) an upper and lower crust with large lateral changes in velocity and thickness, (3) a north-dipping subducting plate below Cyprus with a steepening of the dip-angle of the plate at about 45 km depth. Thus, the wide-angle seismic and gravity data provide detailed insights into the 2-D geometry and velocity structures associated with the Cyprus Arc collision zone. Finally, integrated analysis of the geophysics and geology allows a comprehensive interpretation of the crustal structure related to the collision process.
Schmidt, Thorsten Ingo ; Ulrich, Peter ; Büchner, Christiane ; Franzke, Jochen ; Jann, Werner ; Bauer, Hartmut ; Wagner, Dieter ; Brüning, Christoph ; Bickenbach, Christian ; Kuhlmann, Sabine ; Peters, Niklas ; Reichard, Christoph ; Tessmann, Jens ; Maaß, Christian ; Kern, Kristine ; Kochskämper, Elisa ; Gailing, Ludger ; Krzymuski, Marcin
Zum dreißigjährigen Bestehen des Kommunalwissenschaftlichen Instituts an der Universität Potsdam vereint dieser Jubiläumsband kurze Aufsätze von ehemaligen und aktuellen Vorstandsmitgliedern, von Ehrenmitgliedern des Vorstands, langjährigen wissenschaftlichen Mitarbeitern des Instituts und aktuellen wissenschaftlichen Kooperationspartnern. Die insgesamt zwölf Beiträge befassen sich mit den Kommunalwissenschaften und der Geschichte des Kommunalwissenschaftlichen Instituts, mit aktuellen kommunalwissenschaftlichen Fragestellungen und wissenschaftlichen Kooperationen des KWI. Der vom KWI-Vorstand herausgegebene Band soll einen breiten Blick auf 30 Jahre Kommunalwissenschaften in Brandenburg und an der Universität Potsdam werfen und einen Ausblick auf zukünftige kommunalwissenschaftliche Forschung geben.
Stillmark, Hans-Christian ; Limberg, Jörg ; Götzmann, Jutta ; Vogt, Jochen ; Eke, Norbert Otto ; Braun, Matthias ; Clare, Jennifer ; Grimm, Christa ; Hofmann, Michael ; Bauer, Gerhard ; Starke, Frank
Der Band versammelt verschiedenen Beiträge, die sich mit dem Leben und Werk von Peter Weiss auseinandersetzen. Die Beiträge wurden auf der Konferenz "Peter Weiss - 100" anläßlich des hundertsten Geburtstages des Autors im Jahre 2016 in Potsdam gehalten. Dabei wirkten unterschiedliche Einrichtungen und Institutionen erstmals gemeinsam im Geburtsort des Künstlers.
Voigt, Christian ; Scholl, Julia M. ; Bauer, Juliane ; Teige, Tobias ; Yovel, Yossi ; Kramer-Schadt, Stephanie ; Gras, Pierre
Context Cities are a challenging habitat for obligate nocturnal mammals because of the ubiquitous use of artificial light at night (ALAN). How nocturnal animals move in an urban landscape, particularly in response to ALAN is largely unknown. Objectives We studied the movement responses, foraging and commuting, of common noctules (Nyctalus noctula) to urban landscape features in general and ALAN in particular. Methods We equipped 20 bats with miniaturized GPS loggers in the Berlin metropolitan area and related spatial positions of bats to anthropogenic and natural landscape features and levels of ALAN. Results Common noctules foraged close to ALAN only next to bodies of water or well vegetated areas, probably to exploit swarms of insects lured by street lights. In contrast, they avoided illuminated roads, irrespective of vegetation cover nearby. Predictive maps identified most of the metropolitan area as non-favoured by this species because of high levels of impervious surfaces and ALAN. Dark corridors were used by common noctules for commuting and thus likely improved the permeability of the city landscape. Conclusions We conclude that the spatial use of common noctules, previously considered to be more tolerant to light than other bats, is largely constrained by ALAN. Our study is the first individual-based GPS tracking study to show sensitive responses of nocturnal wildlife to light pollution. Approaches to protect urban biodiversity need to include ALAN to safeguard the larger network of dark habitats for bats and other nocturnal species in cities.
Rollnik, Jens D. ; Adolphsen, Jens ; Bauer, J. ; Bertram, Maja ; Brocke, Jan ; Dohmen, Christian ; Donauer, E. ; Hartwich, Mathias ; Heidler, Maria Dorothea ; Huge, Volker ; Klarmann, Silke ; Lorenzl, Stefan ; Lück, Michelle ; Mertl-Rötzer, Marion ; Mokrusch, Thomas ; Nowak, D. A. ; Platz, Tanja ; Riechmann, Lutz ; Schlachetzki, Felix ; von Helden, Alvin ; Wallesch, C. W. ; Zergiebel, D. ; Pohl, M.
Das prolongierte Weaning von Patienten mit neurologischen oder neurochirurgischen Erkrankungen weist Besonderheiten auf, denen die Deutsche Gesellschaft für Neurorehabilitation e. V. in einer eigenen Leitlinie Rechnung trägt.
Im Hinblick auf Definitionen (z. B. Weaningerfolg und -versagen), Weaningkategorien, Pathophysiologie des Weaningversagens und allgemeine Weaningstrategien wird ausdrücklich auf die aktuelle S2k-Leitlinie der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V. verwiesen.
In der neurologisch-neurochirurgischen Frührehabilitation werden Patienten mit zentralen Störungen der Atmungsregulation (z. B. Hirnstammläsionen), des Schluckaktes (neurogene Dysphagien), mit neuromuskulären Problemen (z. B. Critical-illness-Polyneuropathie, Guillain-Barre-Syndrom, Querschnittlähmungen, Myasthenia gravis) und/oder kognitiven Störungen (z. B. Bewusstseins- und Vigilanzstörungen, schwere Kommunikationsstörungen) versorgt, deren Betreuung bei der Entwöhnung von der Beatmung neben intensivmedizinischer Kompetenz auch neurologische bzw. neurochirurgische und neurorehabilitative Expertise erfordert. In Deutschland wird diese Kompetenz in Zentren der neurologisch-neurochirurgischen Frührehabilitation vorgehalten, und zwar als Krankenhausbehandlung.
Der Leitlinie liegt eine systematische Recherche von Leitliniendatenbanken und Medline zugrunde. Unter Moderation durch die Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) erfolgte die Konsensfindung mittels nominalen Gruppenprozesses und Delphi-Verfahren.
In der vorliegenden Leitlinie der DGNR wird auf die strukturellen und inhaltlichen Besonderheiten der neurologisch-neurochirurgischen Frührehabilitation sowie vorhandene Studien zum Weaning in Frührehabilitationseinrichtungen eingegangen.
Adressaten der Leitlinie sind Neurologen, Neurochirurgen, Anästhesisten, Palliativmediziner, Logopäden, Intensivpflegekräfte, Ergotherapeuten, Physiotherapeuten und Neuropsychologen. Ferner richtet sich diese Leitlinie zur Information an Fachärzte für Physikalische Medizin und Rehabilitation (PMR), Pneumologen, Internisten, Atmungstherapeuten, den Medizinischen Dienst der Krankenkassen (MDK) und des Spitzenverbands Bund der Krankenkassen e. V. (MDS). Das wesentliche Ziel dieser Leitlinie ist es, den aktuellen Wissensstand zum Thema „Prolongiertes Weaning in der neurologisch-neurochirurgischen Frührehabilitation“ zu vermitteln.
Scheller, Frieder W. ; Bauer, Christian G. ; Makower, Alexander ; Wollenberger, Ursula ; Warsinke, Axel ; Bier, Frank Fabian
Scheller, Frieder W. ; Bauer, Christian G. ; Markower, Alexander ; Wollenberger, Ursula ; Warsinke, Axel ; Bier, Frank Fabian
Bauer, Christian G. ; Eremenko, A. V. ; Ehrentreich-Förster, Eva ; Bier, Frank Fabian ; Makower, Alexander ; Halsall, H. B. ; Heineman, W. R. ; Scheller, Frieder W.
Ultrasensitive biosensors
(1996)
Bier, Frank Fabian ; Ehrentreich-Förster, Eva ; Scheller, Frieder W. ; Makower, Alexander ; Eremenko, A. V. ; Wollenberger, Ursula ; Bauer, Christian G. ; Pfeiffer, Dorothea ; Micheel, Burkhard
Ghindilis, A. L. ; Makower, Alexander ; Bauer, Christian G. ; Bier, Frank Fabian ; Scheller, Frieder W.
Scheller, Frieder W. ; Makower, Alexander ; Ghindilis, A. L. ; Bier, Frank Fabian ; Ehrentreich-Förster, Eva ; Wollenberger, Ursula ; Bauer, Christian G. ; Micheel, Burkhard ; Pfeiffer, Dorothea ; Szeponik, Jan ; Michael, N. ; Kaden, H.
Hanack, Katja ; Schloer, Anja ; Holzloehner, Pamela ; Listek, Martin ; Bauer, Cindy ; Butze, Monique ; Micheel, Burkhard ; Hentschel, Christian ; Sowa, Mandy ; Roggenbuck, Dirk ; Schierack, Peter ; Fuener, Jonas ; Schliebs, Erik ; Goihl, Alexander ; Reinhold, Dirk
Pancreatic secretory zymogen-granule membrane glycoprotein 2 (GP2) has been identified to be a major autoantigenic target in Crohn’s disease patients. It was discussed recently that a long and a short isoform of GP2 exists whereas the short isoform is often detected by GP2-specific autoantibodies. In the outcome of inflammatory bowel diseases, these GP2-specific autoantibodies are discussed as new serological markers for diagnosis and therapeutic monitoring. To investigate this further, camelid nanobodies were generated by phage display and selected against the short isoform of GP2 in order to isolate specific tools for the discrimination of both isoforms. Nanobodies are single domain antibodies derived from camelid heavy chain only antibodies and characterized by a high stability and solubility. The selected candidates were expressed, purified and validated regarding their binding properties in different enzyme-linked immunosorbent assays formats, immunofluorescence, immunohistochemistry and surface plasmon resonance spectroscopy. Four different nanobodies could be selected whereof three recognize the short isoform of GP2 very specifically and one nanobody showed a high binding capacity for both isoforms. The KD values measured for all nanobodies were between 1.3 nM and 2.3 pM indicating highly specific binders suitable for the application as diagnostic tool in inflammatory bowel disease.
Eremenko, A. V. ; Makower, Alexander ; Bauer, Christian G. ; Kurochkin, I. N. ; Scheller, Frieder W.
The geothermal potential in Tarutung is controlled by both the Sumatra Fault system and young arc volcanism. In this study we use the spatial distribution of seismic attenuation, calculated from local earthquake recordings, to image the 3-D seismic attenuation of the area and relate it with the temperature anomalies and the fluid distribution of the subsurface. A temporary seismic network of 42 stations was deployed around Tarutung and Sarulla (south of Tarutung) for a period of 10 months starting in 2011 May. Within this period, the network recorded 2586 local events. A high-quality subset of 229 events recorded by at least 10 stations was used for the attenuation inversion (tomography). Path-average attenuation (t(p)*) was calculated by using a spectral inversion method. The spread function, the contour lines of the model resolution matrix and the recovery test results show that our 3-D attenuation model (Q(p)) has good resolution around the Tarutung Basin and along the Sarulla graben. High attenuation (low Q(p)) related to the geothermal system is found in the northeast of the Tarutung Basin suggesting fluid pathways from below the Sumatra Fault. The upper part of the studied geothermal system in the Tarutung district seems to be mainly controlled by the fault structure rather than by magmatic activities. In the southwest of the Tarutung Basin, the high attenuation zone is associated with the Martimbang volcano. In the Sarulla region, a low-Q(p) anomaly is found along the graben within the vicinity of the Hopong caldera.
Eremenko, Arkadi V. ; Bauer, Christian G. ; Makower, Alexander ; Kanne, Beate ; Baumgarten, Horst ; Scheller, Frieder W.