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Background Anxiety and depressive disorders share common features of mood dysfunctions. This has stimulated interest in transdiagnostic dimensional research as proposed by the Research Domain Criteria (RDoC) approach by the National Institute of Mental Health (NIMH) aiming to improve the understanding of underlying disease mechanisms. The purpose of this study was to investigate the processing of RDoC domains in relation to disease severity in order to identify latent disorder-specific as well as transdiagnostic indicators of disease severity in patients with anxiety and depressive disorders.
Methods Within the German research network for mental disorders, 895 participants (n = 476 female, n = 602 anxiety disorder, n = 257 depressive disorder) were recruited for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) and included in this cross-sectional study. We performed incremental regression models to investigate the association of four RDoC domains on disease severity in patients with affective disorders: Positive (PVS) and Negative Valance System (NVS), Cognitive Systems (CS) and Social Processes (SP).
Results The results confirmed a transdiagnostic relationship for all four domains, as we found significant main effects on disease severity within domain-specific models (PVS: & beta; = -0.35; NVS: & beta; = 0.39; CS: & beta; = -0.12; SP: & beta; = -0.32). We also found three significant interaction effects with main diagnosis showing a disease-specific association.
Limitations The cross-sectional study design prevents causal conclusions. Further limitations include possible outliers and heteroskedasticity in all regression models which we appropriately controlled for.
Conclusion Our key results show that symptom burden in anxiety and depressive disorders is associated with latent RDoC indicators in transdiagnostic and disease-specific ways.
This study aimed to build on the relationship of well-established self-report and behavioral assessments to the latent constructs positive (PVS) and negative valence systems (NVS), cognitive systems (CS), and social processes (SP) of the Research Domain Criteria (RDoC) framework in a large transnosological population which cuts across DSM/ICD-10 disorder criteria categories. One thousand four hundred and thirty one participants (42.1% suffering from anxiety/fear-related, 18.2% from depressive, 7.9% from schizophrenia spectrum, 7.5% from bipolar, 3.4% from autism spectrum, 2.2% from other disorders, 18.4% healthy controls, and 0.2% with no diagnosis specified) recruited in studies within the German research network for mental disorders for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) were examined with a Mini-RDoC-Assessment including behavioral and self-report measures. The respective data was analyzed with confirmatory factor analysis (CFA) to delineate the underlying latent RDoC-structure. A revised four-factor model reflecting the core domains positive and negative valence systems as well as cognitive systems and social processes showed a good fit across this sample and showed significantly better fit compared to a one factor solution. The connections between the domains PVS, NVS and SP could be substantiated, indicating a universal latent structure spanning across known nosological entities. This study is the first to give an impression on the latent structure and intercorrelations between four core Research Domain Criteria in a transnosological sample. We emphasize the possibility of using already existing and well validated self-report and behavioral measurements to capture aspects of the latent structure informed by the RDoC matrix.
Silk protein-based materials show promise for application as biomaterials for tissue engineering. The simple and rapid photochemical modification of silk protein-based materials composed of either Bombyx mori silkworm silk or engineered spider silk proteins (eADF4(C16)) is reported. Radicals formed on the silk-based materials initiate the polymerization of monomers (acrylic acid, methacrylic acid, or allylamine) which functionalize the surface of the silk materials with poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), or poly(allylamine) (PAAm). To demonstrate potential applications of this type of modification, the polymer-modified silks are mineralized. The PAA- and PMAA-functionalized silks are mineralized with calcium carbonate, whereas the PAAm-functionalized silks are mineralized with silica, both of which provide a coating on the materials that may be useful for bone tissue engineering, which will be the subject of future investigations.
Understanding the natural history of model organisms is important for the effective use of their genomic resourses. Arabidopsis lyrata has emerged as a useful plant for studying ecological and evolutionary genetics, based on its extensive natural variation, sequenced genome and close relationship to A. thaliana. We studied genetic diversity across the entire range of European Arabidopsis lyrata ssp. petraea, in order to explore how population history has influenced population structure. We sampled multiple populations from each region, using nuclear and chloroplast genome markers, and combined population genetic and phylogeographic approaches. Within-population diversity is substantial for nuclear allozyme markers (mean P = 0.610, A(e) = 1.580, H-e = 0.277) and significantly partitioned among populations (F- ST = 0.271). The Northern populations have modestly increased inbreeding (F-IS = 0.163 verses F-IS = 0.093), but retain comparable diversity to central European populations. Bottlenecks are common among central and northern Europe populations, indicating recent demographic history as a dominant factor in structuring the European diversity. Although the genetic structure was detected at all geographic scales, two clear differentiated units covering northern and central European areas (F-CT = 0.155) were identified by Bayesian analysis and supported by regional pairwise F-CT calculations. A highly similar geographic pattern was observed from the distribution of chloroplast haplotypes, with the dominant northern haplotypes absent from central Europe. We conclude A. l. petraea's cold-tolerance and preference for disturbed habitats enabled glacial survival between the alpine and Nordic glaciers in central Europe and an additional cryptic refugium. While German populations are probable peri-glacial leftovers, Eastern Austrian populations have diversity patterns possibly compatible with longer-term survival.
The majority of cases of community-acquired pneumonia are caused by Streptococcus pneumoniae and most studies on pneumococcal host interaction are based on cell culture or animal experiments. Thus, little is known about infections in human lung tissue.
Cyclooxygenase-2 and its metabolites play an important regulatory role in lung inflammation. Therefore, we established a pneumococcal infection model on human lung tissue demonstrating mitogen-activated protein kinase (MAPK)-dependent induction of cyclooxygenase-2 and its related metabolites.
In addition to alveolar macrophages and the vascular endothelium, cyclooxygenase-2 was upregulated in alveolar type II but not type I epithelial cells, which was confirmed in lungs of patients suffering from acute pneumonia. Moreover, we demonstrated the expression profile of all four E prostanoid receptors at the mRNA level and showed functionality of the E prostanoid(4) receptor by cyclic adenosine monophosphate production. Additionally, in comparison to previous studies, cyclooxygenase-2/prostaglandin E-2 related pro- and anti-inflammatory mediator regulation was partly confirmed in human lung tissue after pneumococcal infection.
Overall, cell type-specific and MAPK-dependent cyclooxygenase-2 expression and prostaglandin E-2 formation in human lung tissue may play an important role in the early phase of pneumococcal infections.
Reflexion ist eine Schlüsselkategorie für die professionelle Entwicklung von Lehrkräften, welche als Ausbildungsziel in den Bildungsstandards für die Lehrkräftebildung verankert ist. Eine Verstetigung universitär geprägter Forschung und Modellierung in der praxisnahen Anwendung im schulischen Kontext bietet Potentiale nachhaltiger Professionalisierung. Die Stärkung reflexionsbezogener Kompetenzen durch Empirie und Anwendung scheint eine phasenübergreifende Herausforderung der Lehrkräftebildung zu sein, die es zu bewältigen gilt. Ziele des Tagungsbandes Reflexion in der Lehrkräftebildung sind eine theoretische Schärfung des Konzeptes „Reflexive Professionalisierung“ und der Austausch über Fragen der Einbettung wirksamer reflexionsbezogener Lerngelegenheiten in die Lehrkräftebildung. Forschende und Lehrende der‚ drei Phasen (Studium, Referendariat sowie Fort- und Weiterbildung) der Lehrkräftebildung stellen Lehrkonzepte und Forschungsprojekte zum Thema Reflexion in der Lehrkräftebildung vor und diskutieren diese. Gemeinsam mit Teilnehmenden aller Phasen und von verschiedenen Standorten der Lehrkräftebildung werden zukünftige Herausforderungen identifiziert und Lösungsansätze herausgearbeitet.
A silica undersaturated alkali-olivine basanitic magma intruded the late Paleocene/early Eocene Jafnayn Formation near Muscat. Geochemical analyses indicate that a significant amount of host rock (limestone) was assimilated into the magma. We dated the basanite as 42.7 +/- 1.0 Ma (2 sigma error; late Lutetian), using the whole rock Ar-40/Ar-39 step-wise heating technique. Intrusion occurred in the hanging wall of a major regional extensional shear zone (Frontal Range Fault, FRF) bounding the northern margin of two domes within the Oman Mountains (Jabal Akhdar and Saih Hatat domes). Two shear intervals along the FRF have been documented. The first interval lasted immediately after emplacement of the Semail Ophiolite (latest Cretaceous-early Eocene) while the second and poorly constrained interval was assumed to have occurred during the Oligocene.
The proximity of the basanite to the FRF suggests that magma used extensional faults for the upper part of its ascent path. Reactivated Permian rift faults of the Pangaea rift or other preexisting faults may have been used for the lower ascent part.
We conclude that the basanite intrusion coincided with the onset of the second deformation interval along the FRF, because (1) the position of the basanite is near a dextral releasing bend, associated with the second shear interval, (2) the overlap of our Ar-40/Ar-39 age with the cooling curves for rocks from the nearby Jabal Akhdar Dome, and (3) the basanite postdates the first FRF deformation episode by > 10 Ma. Thus, the second interval along the FRF had started already during the late Lutetian and probably lasted into the Miocene.
Objectives: Severe pneumonia may evoke acute lung injury, and sphingosine-1-phosphate is involved in the regulation of vascular permeability and immune responses. However, the role of sphingosine-1-phosphate and the sphingosine-1-phosphate producing sphingosine kinase 1 in pneumonia remains elusive. We examined the role of the sphingosine-1-phosphate system in regulating pulmonary vascular barrier function in bacterial pneumonia. Design: Controlled, in vitro, ex vivo, and in vivo laboratory study. Subjects: Female wild-type and SphK1-deficient mice, 8-10 weeks old. Human postmortem lung tissue, human blood-derived macrophages, and pulmonary microvascular endothelial cells. Interventions: Wild-type and SphK1-deficient mice were infected with Streptococcus pneumoniae. Pulmonary sphingosine-1-phosphate levels, messenger RNA expression, and permeability as well as lung morphology were analyzed. Human blood-derived macrophages and human pulmonary microvascular endothelial cells were infected with S. pneumoniae. Transcellular electrical resistance of human pulmonary microvascular endothelial cell monolayers was examined. Further, permeability of murine isolated perfused lungs was determined following exposition to sphingosine-1-phosphate and pneumolysin. Measurements and Main Results: Following S. pneumoniae infection, murine pulmonary sphingosine-1-phosphate levels and sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 expression were increased. Pneumonia-induced lung hyperpermeability was reduced in SphK1(-/-) mice compared with wild-type mice. Expression of sphingosine kinase 1 in macrophages recruited to inflamed lung areas in pneumonia was observed in murine and human lungs. S. pneumoniae induced the sphingosine kinase 1/sphingosine-1-phosphate system in blood-derived macrophages and enhanced sphingosine-1-phosphate receptor 2 expression in human pulmonary microvascular endothelial cell in vitro. In isolated mouse lungs, pneumolysin-induced hyperpermeability was dose dependently and synergistically increased by sphingosine-1-phosphate. This sphingosine-1-phosphate-induced increase was reduced by inhibition of sphingosine-1-phosphate receptor 2 or its downstream effector Rho-kinase. Conclusions: Our data suggest that targeting the sphingosine kinase 1-/sphingosine-1-phosphate-/sphingosine-1-phosphate receptor 2-signaling pathway in the lung may provide a novel therapeutic perspective in pneumococcal pneumonia for prevention of acute lung injury.
Genossenschaften wirken auf manche wie ein angestaubtes Relikt aus der Vergangenheit. Das eingetrübte Image überrascht. Denn Genossenschaften haben sich immer wieder als besonders krisenfest erwiesen und längst auch als erfolgreiches Zukunftsmodell entpuppt. Der stetige Zuwachs an Neugründungen, die steigenden Mitgliederzahlen und die ständige Ausweitung der Aktionsfelder bestätigen die hohe Attraktivität. Dem entspricht eine enorme Einsatzbreite der Genossenschaftsidee. Sie reicht von Agrargenossenschaften über Produktionsgenossenschaften in Handel, Handwerk und Gewerbe bis hin zu sehr modernen Bereichen etwa der neuen Informations- und Kommunikationstechnologien. In all diesen und vielen anderen Segmenten finden sich variantenreiche genossenschaftliche Gestaltungsoptionen nach Maximen wie Selbsthilfe, Solidarität, Bürgerengagement, Partizipation, Mitglieder- und Gemeinwohlorientierung. Inzwischen lockt die hohe Anziehungskraft der Genossenschaftsidee auch die Kommunen. Angestoßen durch gesetzgeberische Impulse erleben die Genossenschaften auf der kommunalen Ebene derzeit bundesweit einen richtigen Aufschwung. Die Aufwertung erweitert die Überlegungen zur Gewährleistung und Optimierung kommunaler Leistungserbringung um eine wichtige Gestaltungsvariante, nimmt aber den Kommunen die Auswahlentscheidung nicht ab. Denn wie bei allen Organisationsentscheidungen ist vor dem Rückgriff auf genossenschaftliche Organisationsformen in jedem Einzelfall eine nüchterne aufgaben-, sach- und situationsbezogene Vergleichsanalyse geboten, die den Entscheidungsträgern spezifische Kenntnisse und detaillierte Fachkompetenz abverlangt. Die 19. Fachtagung des KWI diskutiert rechtliche Rahmenbedingungen und normative Direktiven, praktische Erfahrungen, Einsatzfelder, Erfolgsbedingungen und Fallstricke in der Praxis.
Background:
The overall goal of the project ‘StiEL’ is to contribute to the professional development of teachers and other educational staff working at German secondary schools. The aim is to develop an evidence-based training concept for the inclusion of students with diverse abilities. The project is organized as a collaborative research effort of three partnering institutions and funded by the German Federal Ministry of Education and Research from 2018-2021.
Methods:
To support the on-going transition towards inclusive school practices, a multi-stage approach is envisaged. The first phase aims at a scoping review of existing literature and programmes on inclusion. The overview is supplemented by interviews with school staff members. Training modules are developed in the second project phase. The third phase of StiEL puts the newly developed training program into practice. The knowledge and skills acquired by the participants through the training as well as the teaching and management of inclusive classrooms after the training are evaluated through longitudinal and ethnographic approaches. The final project phase creates a best practice manual and makes the modules available via open access databases.
Results:
The presentation will focus on the first phase and try to explore the health-related consequences of the transition towards an inclusive school system in Germany for different participants. We will present preliminary results of expert interviews as well as some results from the literature screening. Due to our findings the current practice on German schools towards the road to inclusion is very stressful for all participants. We will explore recommendations for health promoting schools under conditions of inclusion.
Conclusions:
In terms of health-related consequences for all participants, the road to inclusion is very ambitious but also very stressful. Regarding the development of an inclusive school system, we need to focus much more on health and health promotion.
Investigation of transient soil moisture profiles yields valuable information of near- surface processes. A recently developed reconstruction algorithm based on the telegraph equation allows the inverse estimation of soil moisture profiles along coated, three rod TDR probes. Laboratory experiments were carried out to prove the results of the inversion and to understand the influence of probe rod deformation and solid objects close to the probe in heterogonous media. Differences in rod geometry can lead to serious misinterpretations in the soil moisture profile but have small influence on the average soil moisture along the probe. Solids in the integration volume have almost no effect on average soil moisture but result in locally slightly decreased moisture values. Inverted profiles obtained in a loamy soil with a clay content of about 16% were in good agreement with independent measurements.
Investigation of transient soil moisture profiles yields valuable information of near- surface processes. A recently developed reconstruction algorithm based on the telegraph equation allows the inverse estimation of soil moisture profiles along coated, three rod TDR probes. Laboratory experiments were carried out to prove the results of the inversion and to understand the influence of probe rod deformation and solid objects close to the probe in heterogeneous media. Differences in rod geometry can lead to serious misinterpretations in the soil moisture profile, but have small influence on the average soil moisture along the probe. Solids in the integration volume have almost no effect on average soil moisture, but result in locally slightly decreased moisture values. Inverted profiles obtained in a loamy soil with a clay content of about 16% were in good agreement with independent measurements.
This study presents an application of an innovative sampling strategy to assess soil moisture dynamics in a headwater of the Weisseritz in the German eastern Ore Mountains. A grassland site and a forested site were instrumented with two Spatial TDR clusters (STDR) that consist of 39 and 32 coated TDR probes of 60 cm length. Distributed time series of vertically averaged soil moisture data from both sites/ensembles were analyzed by statistical and geostatistical methods. Spatial variability and the spatial mean at the forested site were larger than at the grassland site. Furthermore, clustering of TDR probes in combination with long-term monitoring allowed identification of average spatial covariance structures at the small field scale for different wetness states. The correlation length of soil water content as well as the sill to nugget ratio at the grassland site increased with increasing average wetness and but, in contrast, were constant at the forested site. As soil properties at both the forested and grassland sites are extremely variable, this suggests that the correlation structure at the forested site is dominated by the pattern of throughfall and interception. We also found a very strong correlation between antecedent soil moisture at the forested site and runoff coefficients of rainfall-runoff events observed at gauge Rehefeld. Antecedent soil moisture at the forest site explains 92% of the variability in the runoff coefficients. By combining these results with a recession analysis we derived a first conceptual model of the dominant runoff mechanisms operating in this catchment. Finally, we employed a physically based hydrological model to shed light on the controls of soil- and plant morphological parameters on soil average soil moisture at the forested site and the grassland site, respectively. A homogeneous soil setup allowed, after fine tuning of plant morphological parameters, most of the time unbiased predictions of the observed average soil conditions observed at both field sites. We conclude that the proposed sampling strategy of clustering TDR probes is suitable to assess unbiased average soil moisture dynamics in critical functional units, in this case the forested site, which is a much better predictor for event scale runoff formation than pre-event discharge. Long term monitoring of such critical landscape elements could maybe yield valuable information for flood warning in headwaters. We thus think that STDR provides a good intersect of the advantages of permanent sampling and spatially highly resolved soil moisture sampling using mobile rods.
This study presents an application of an innovative sampling strategy to assess soil moisture dynamics in a headwater of the Weißeritz in the German eastern Ore Mountains. A grassland site and a forested site were instrumented with two Spatial TDR clusters (STDR) that consist of 39 and 32 coated TDR probes of 60 cm length. Distributed time series of vertically averaged soil moisture data from both sites/ensembles were analyzed by statistical and geostatistical methods. Spatial variability and the spatial mean at the forested site were larger than at the grassland site. Furthermore, clustering of TDR probes in combination with long-term monitoring allowed identification of average spatial covariance structures at the small field scale for different wetness states. The correlation length of soil water content as well as the sill to nugget ratio at the grassland site increased with increasing average wetness and but, in contrast, were constant at the forested site. As soil properties at both the forested and grassland sites are extremely variable, this suggests that the correlation structure at the forested site is dominated by the pattern of throughfall and interception. We also found a strong correlation between average soil moisture dynamics and runoff coefficients of rainfall-runoff events observed at gauge Rehefeld, which explains almost as much variability in the runoff coefficients as pre-event discharge. By combining these results with a recession analysis we derived a first conceptual model of the dominant runoff mechanisms operating in this catchment. Finally, long term simulations with a physically based hydrological model were in good/acceptable accordance with the time series of spatial average soil water content observed at the forested site and the grassland site, respectively. Both simulations used a homogeneous soil setup that closely reproduces observed average soil conditions observed at the field sites. This corroborates the proposed sampling strategy of clustering TDR probes in typical functional units is a promising technique to explore the soil moisture control on runoff generation. Long term monitoring of such sites could maybe yield valuable information for flood warning. The sampling strategy helps furthermore to unravel different types of soil moisture variability.
Purpose: The present work aimed to delineate (i) a revised protocol according to recent methodological developments in evidence generation, to (ii) describe its interpretation, the assessment of the overall certainty of evidence and to (iii) outline an Evidence to Decision framework for deriving an evidence-based guideline on quantitative and qualitative aspects of dietary protein intake. Methods A methodological protocol to systematically investigate the association between dietary protein intake and several health outcomes and for deriving dietary protein intake recommendations for the primary prevention of various non-communicable diseases in the general adult population was developed. Results The developed methodological protocol relies on umbrella reviews including systematic reviews with or without meta-analyses. Systematic literature searches in three databases will be performed for each health-related outcome. The methodological quality of all selected systematic reviews will be evaluated using a modified version of AMSTAR 2, and the outcome-specific certainty of evidence for systematic reviews with or without meta-analysis will be assessed with NutriGrade. The general outline of the Evidence to Decision framework foresees that recommendations in the derived guideline will be given based on the overall certainty of evidence as well as on additional criteria such as sustainability. Conclusion The methodological protocol permits a systematic evaluation of published systematic reviews on dietary protein intake and its association with selected health-related outcomes. An Evidence to Decision framework will be the basis for the overall conclusions and the resulting recommendations for dietary protein intake.
Diese eher ungewöhnliche, aber sehr persönlich gehaltene Festschrift ist dem langjährigen Wirken von Dr. Christiane Büchner als „Geschäftsführerin“ am Kommunalwissenschaftlichen Institut (KWI) der Universität Potsdam gewidmet. Die von Prof. Jochen Franzke zusammengestellte und herausgegebene Publikation enthält im ersten Teil neben dem Grußwort des Geschäftsführenden Direktors des KWI Herrn Prof. Thorsten Ingo Schmidt eine Reihe persönlicher Würdigungen von Kolleginnen und Kollegen, Gastwissenschaftlern und Mitarbeitenden, die seit 1994 in verschiedenen Phasen der Entwicklung des KWIs mit Dr. Christiane Büchner eng zusammengearbeitet haben. Der abschließende Dokumentationsteil der Publikation enthält neben Auszügen aus dem Schriftenverzeichnis von Dr. Christiane Büchner auch zwei Nachdrucke aus deren Feder zum Thema der Kreisgebietsreform in Brandenburg (von 2001) sowie über den Landkreis Barnim (von 2019).