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- regional history (11)
- rehabilitation (11)
- renewable energy (11)
- retrieval (11)
- ring-opening polymerization (11)
- salivary gland (11)
- simulations (11)
- social cognition (11)
- speech and language therapy (11)
- speech production (11)
- stars: winds (11)
- sulfur (11)
- transfer (11)
- vegetation (11)
- Aimé Bonpland (10)
- Apis mellifera (10)
- Atmosphäre (10)
- Big Data (10)
- Bilingualismus (10)
- Blockchain (10)
- Body waves (10)
- Briefedition und -korrespondenz (10)
- Centrosome (10)
- Christentum (10)
- Corona (10)
- Cortisol (10)
- Database (10)
- Datenschutz (10)
- Deutsche Literatur der Frühen Neuzeit (10)
- Diatoms (10)
- Doping (10)
- Drama (10)
- Electromyography (10)
- Essai politique sur l'île de Cuba (10)
- FGF21 (10)
- Finanzkrise (10)
- Franconia (10)
- Franken (10)
- GDR (10)
- Galaxy: evolution (10)
- Genetics (10)
- Great Britain (10)
- Großbritannien (10)
- Hasso-Plattner-Institut (10)
- Indien (10)
- Inflammation (10)
- Intertextualität (10)
- Intervention (10)
- Inversion (10)
- Ion mobility spectrometry (10)
- Ionic liquids (10)
- Japan (10)
- Kant (10)
- Kinetics (10)
- Kolumbien (10)
- Korruption (10)
- Künstliche Intelligenz (10)
- Manganese (10)
- Mars (10)
- MiSpEx (10)
- Militär / Geschichte (10)
- Model (10)
- Modelling (10)
- Myodes glareolus (10)
- Narcissism (10)
- Naturgefahren (10)
- Nichtlineare Dynamik (10)
- Numerical cognition (10)
- Ostracoda (10)
- Paläoklima (10)
- Pflanzengeographie (10)
- Phylogeny (10)
- Physical activity (10)
- Physik (10)
- Pleistocene (10)
- Polizeisoziologie (10)
- Privacy (10)
- Privatisierung (10)
- Quality of life (10)
- Reflexionskompetenz (10)
- Resilience (10)
- Rhetorik (10)
- Schulforschung (10)
- Sociology (10)
- South America (10)
- Southeast Asia (10)
- Stability (10)
- Stoffwechsel (10)
- Strategie (10)
- Sun: photosphere (10)
- Terrorismus (10)
- Türkei (10)
- Wilhelm von Humboldt (10)
- X-ray diffraction (10)
- Zeitreihenanalyse (10)
- Zentralasien (10)
- accountability (10)
- additive manufacturing (10)
- atomic force microscopy (10)
- back pain (10)
- biophysics (10)
- carbon nitride (10)
- chaos (10)
- child (10)
- climate change adaptation (10)
- cluster expansion (10)
- co-citation analysis (10)
- community (10)
- complex networks (10)
- correlation (10)
- crystallization (10)
- cue-based retrieval (10)
- culture (10)
- decision-making (10)
- diatoms (10)
- discourse analysis (10)
- disease (10)
- exhaustivity (10)
- exposure (10)
- expression (10)
- fitness (10)
- food (10)
- freshwater (10)
- gamma rays: ISM (10)
- gamma-ray burst: general (10)
- gene (10)
- genomics (10)
- gravitational waves (10)
- grazing (10)
- human capital (10)
- human rights (10)
- interactions (10)
- ionic liquid (10)
- justice sensitivity (10)
- language production (10)
- leadership (10)
- light pollution (10)
- literature review (10)
- living cells (10)
- luminescence (10)
- magnetosphere (10)
- manganese (10)
- masked priming (10)
- mental arithmetic (10)
- metabarcoding (10)
- metabolic syndrome (10)
- methodology (10)
- microsatellites (10)
- middle childhood (10)
- mitigation (10)
- molybdenum cofactor (10)
- movement ecology (10)
- nonlinear dynamics (10)
- numerische Modellierung (10)
- operational momentum (10)
- peptide (10)
- peptides (10)
- phenotypic plasticity (10)
- phosphorylation (10)
- postural control (10)
- potassium (10)
- privacy (10)
- productivity (10)
- protein folding (10)
- quantum dots (10)
- representation (10)
- ruthenium (10)
- scene viewing (10)
- second language (10)
- senescence (10)
- stars (10)
- stars: AGB and post-AGB (10)
- strength (10)
- surface plasmon resonance (10)
- systematic literature review (10)
- techniques: imaging spectroscopy (10)
- techniques: photometric (10)
- technology (10)
- training load (10)
- water balance (10)
- water quality (10)
- öffentliche Verwaltung (10)
- α-amylase/trypsin inhibitors (10)
- 20th century (9)
- ADHD (9)
- Albert (9)
- Algorithms (9)
- Antarctica (9)
- Anxiety (9)
- Archiv (9)
- Astronomie (9)
- BPMN (9)
- Bacteria (9)
- Bildungswissenschaften (9)
- Biogeography (9)
- Brachionus calyciflorus (9)
- Camus (9)
- Cauchy problem (9)
- Chaos (9)
- Cold War (9)
- Coordination (9)
- Coping (9)
- Deep Learning (9)
- Design Thinking (9)
- Diskussion-Unterricht (9)
- Eastern Europe (9)
- Ecuador (9)
- Entwicklungszusammenarbeit (9)
- Ernährung (9)
- Eye tracking (9)
- Fragmentation (9)
- Frauen (9)
- Geographie-Didaktik (9)
- Geographie-Studium (9)
- Geographie-Unterricht (9)
- Gold (9)
- Hasso Plattner Institute (9)
- Himalayas (9)
- Holozän (9)
- ISM: structure (9)
- Indian summer monsoon (9)
- Infancy (9)
- Information structure (9)
- Interactional Linguistics (9)
- Kartographie (9)
- Konstruktivismus (9)
- Konversationsanalyse (9)
- Kooperation (9)
- Kuba (9)
- Language (9)
- Lidar (9)
- Mass spectrometry (9)
- Metabolomics (9)
- Metzler Handbuch 2.0 (9)
- Modell (9)
- Modernisierung (9)
- Naturwissenschaft (9)
- Netzwerke (9)
- Open Access (9)
- Oxidative stress (9)
- PHREEQC (9)
- Paleoclimate (9)
- Paris Agreement (9)
- Pregnancy (9)
- Principal component analysis (9)
- Prosodie (9)
- Protein (9)
- Public Management (9)
- Quaternary (9)
- Randomized controlled trial (9)
- Rezeptionsgeschichte (9)
- Russian (9)
- SAXS (9)
- Schulentwicklung (9)
- Selen (9)
- Soil (9)
- Sprachverarbeitung (9)
- Statistical seismology (9)
- Strategies (9)
- Subduction (9)
- Sustainability (9)
- Synthetic methods (9)
- Systembiologie (9)
- Theologie (9)
- Theorie (9)
- Transkriptionsfaktoren (9)
- Translation (9)
- Ukraine (9)
- Umweltschutz (9)
- United Nations (9)
- Verhalten (9)
- Vesikel (9)
- Visualization (9)
- Vorhersage (9)
- Wave propagation (9)
- Weiterbildung (9)
- Weltbegriff (9)
- Weltbewusstsein (9)
- Wissensmanagement (9)
- World Bank (9)
- adipose tissue (9)
- administration (9)
- adolescent (9)
- allometry (9)
- antibody (9)
- authoritarianism (9)
- biofilm (9)
- biomineralization (9)
- block copolymer (9)
- business process management (9)
- cardiovascular disease (9)
- cell adhesion (9)
- charge transfer (9)
- chromatin (9)
- clefts (9)
- clustering (9)
- comparison (9)
- complexity (9)
- conservation genetics (9)
- cosmology: observations (9)
- crisis (9)
- cultural science (9)
- dark ages, reionization, first stars (9)
- decision making (9)
- deutsche Außenpolitik (9)
- diet (9)
- digital health (9)
- disturbance (9)
- dopamine (9)
- educational sciences (9)
- efficiency (9)
- elderly (9)
- elliptic operators (9)
- embodiment (9)
- ethnicity (9)
- executive function (9)
- executive functions (9)
- extreme events (9)
- fatty acids (9)
- films (9)
- flexibility (9)
- forest management (9)
- frequency (9)
- galaxies: interactions (9)
- gold nanoparticles (9)
- inclusive education (9)
- inhibition (9)
- insect (9)
- intelligence (9)
- international organizations (9)
- isometric muscle action (9)
- kitchen (9)
- kitchen culture (9)
- locality (9)
- membrane (9)
- methods (9)
- microscopy (9)
- moderne jüdische Geschichte (9)
- mtDNA (9)
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- perpetration (9)
- persistence (9)
- phylogeography (9)
- physiology (9)
- plasma (9)
- polyzwitterion (9)
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- preparedness (9)
- preview benefit (9)
- professional development (9)
- proteomics (9)
- reactive transport (9)
- reinforcement learning (9)
- relation historique (9)
- resources (9)
- responses (9)
- sea-level rise (9)
- seed dispersal (9)
- selection (9)
- self-esteem (9)
- self-regulation (9)
- sexual scripts (9)
- signal transduction (9)
- skills (9)
- slavic countries (9)
- social inclusion (9)
- soil (9)
- spatial-numerical associations (9)
- species richness (9)
- starch metabolism (9)
- stars: rotation (9)
- statistics (9)
- structure (9)
- surface chemistry (9)
- surface modification (9)
- suspended sediment (9)
- taxonomy (9)
- teaching (9)
- techniques: polarimetric (9)
- virtual reality (9)
- visualization (9)
- waves (9)
- weather (9)
- Öffentliche Verwaltung (9)
- 1814-1831 (8)
- ACT-R (8)
- AFLP (8)
- Alcohol dependence (8)
- Anatolia (8)
- Anpassung (8)
- Arbeitsgedächtnis (8)
- Arenes (8)
- Assessment (8)
- Astrophysik (8)
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- Biographie (8)
- Biomaterial (8)
- Biophysik (8)
- Bombina bombina (8)
- Brownian motion (8)
- Bürgerbeteiligung (8)
- Campylomormyrus (8)
- Carbohydrates (8)
- Childhood (8)
- Colombia (8)
- Competition (8)
- Computational modeling (8)
- Connectivity (8)
- Cosmogenic nuclides (8)
- DFT calculations (8)
- Datenintegration (8)
- Deformation (8)
- Degradation (8)
- Dezentralisierung (8)
- Direct electron transfer (8)
- Discussion (8)
- Diskursanalyse (8)
- E-Government (8)
- E. coli (8)
- East Africa (8)
- East Germany (8)
- Ecology (8)
- Ecosystem services (8)
- Emotionen (8)
- Englischunterricht (8)
- Enthusiasmus (8)
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- Erinnerungskultur (8)
- Fluoreszenz (8)
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- Forschungsdatenmanagement (8)
- Forschungskolleg (8)
- Forschungsprojekte (8)
- Friedrich Wilhelm III. (8)
- Future SOC Lab (8)
- Galaxien (8)
- Geochronology (8)
- Geography Education (8)
- Geschlecht (8)
- Geschäftsprozessmanagement (8)
- Grammatik (8)
- Gravitationswellen (8)
- Holocaust (8)
- Human Rights (8)
- In-Memory Technologie (8)
- Individual differences (8)
- Information Structure (8)
- Insulin resistance (8)
- Interaktion (8)
- Internationale Beziehungen (8)
- Inverse theory (8)
- Johann Gottfried Herder (8)
- Jugendforschung (8)
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- Klausurtagung (8)
- Klimaanpassung (8)
- Kohlenstoff (8)
- Komplexität (8)
- Korrespondenz (8)
- Krise (8)
- Kulturvergleich (8)
- Landsat (8)
- Landslide (8)
- Last Glacial Maximum (8)
- Latein (8)
- Lateinunterricht (8)
- Lepus europaeus (8)
- Ludwig Leichhardt (8)
- MOOCs (8)
- Mannheim Study of Children at Risk (8)
- Menschenrecht (8)
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- Microtus arvalis (8)
- Mikrobiologie (8)
- Mobilität (8)
- Moderne (8)
- Monitoring (8)
- Morphology (8)
- Movement (8)
- Multicore Architekturen (8)
- Namibia (8)
- Nutrition (8)
- Optimization (8)
- Overweight (8)
- PCA (8)
- Patterns (8)
- Photochemie (8)
- Photosynthese (8)
- Phytoplankton (8)
- Polyelektrolyt (8)
- Polyelektrolyte (8)
- Prediction (8)
- Prevention (8)
- Realpolitik (8)
- Security (8)
- Semantik (8)
- Sentence comprehension (8)
- Service-oriented Systems Engineering (8)
- Sphingolipids (8)
- Sport (8)
- Sprachkontakt (8)
- Subduktion (8)
- Sun: chromosphere (8)
- Sun: filaments, prominences (8)
- TAVI (8)
- Tacitus (8)
- Theoretical calculations (8)
- Through-space NMR shieldings (TSNMRS) (8)
- Validation (8)
- Vitamin A (8)
- Wahlen (8)
- X-ray refraction (8)
- X-ray structure (8)
- Younger Dryas (8)
- Zeitgenossen (8)
- Zentraleuropa (8)
- Zooplankton (8)
- acceleration (8)
- acculturation (8)
- algae (8)
- alien species (8)
- amerikanische Reisetagebücher (8)
- arithmetic (8)
- astrophysics (8)
- attitude (8)
- attitudes (8)
- auxin (8)
- bicameralism (8)
- biomaterial (8)
- brain (8)
- cAMP (8)
- carbon cycle (8)
- cardiovascular diseases (8)
- cells (8)
- chemistry (8)
- chemotaxis (8)
- chronic kidney disease (8)
- climate impacts (8)
- climate variability (8)
- cloud (8)
- coherence (8)
- competence (8)
- complex systems (8)
- consistency (8)
- control (8)
- convection (8)
- coronary artery disease (8)
- cytotoxicity (8)
- data integration (8)
- data profiling (8)
- density functional calculations (8)
- dielectrophoresis (8)
- digitale Medien (8)
- dissociative electron attachment (8)
- distribution (8)
- ecosystems (8)
- electron transfer (8)
- electrospinning (8)
- energy (8)
- energy policy (8)
- enzymes (8)
- ethics (8)
- experiments (8)
- fiscal policy (8)
- flow (8)
- food web (8)
- force (8)
- fractional Brownian motion (8)
- galaxies (8)
- gamma-rays: galaxies (8)
- gender differences (8)
- genetics (8)
- geochemistry (8)
- geophysics (8)
- grain size (8)
- home range (8)
- human physical conditioning (8)
- hybridization (8)
- hypertension (8)
- imaging (8)
- immigration (8)
- immobilization (8)
- inference (8)
- injury risk (8)
- instability (8)
- insurance (8)
- isomerization (8)
- land use change (8)
- landscape of fear (8)
- language contact (8)
- light (8)
- major depressive disorder (8)
- malnutrition (8)
- mathematical modeling (8)
- mathematische Modellierung (8)
- meaning (8)
- measurement (8)
- mechanisms (8)
- mechanobiology (8)
- media violence (8)
- membranes (8)
- metabolite profiling (8)
- methane (8)
- microfluidics (8)
- microstructure (8)
- military (8)
- mobility (8)
- modality (8)
- morphological processing (8)
- motor control (8)
- music (8)
- nanocomposite (8)
- narcissism (8)
- natural language processing (8)
- natural products (8)
- neuroplasticity (8)
- noise (8)
- nuclear envelope (8)
- nuclear lamina (8)
- numerical relativity (8)
- numerical simulation (8)
- organization (8)
- outflows (8)
- parliamentary government (8)
- perceptual span (8)
- phonological awareness (8)
- physics (8)
- plankton (8)
- polarization (8)
- policy (8)
- polyelectrolyte (8)
- polyunsaturated fatty acids (8)
- production control (8)
- programming (8)
- pronouns (8)
- propensity score matching (8)
- psychotherapy training (8)
- public health (8)
- quality assurance (8)
- quasars: general (8)
- reanalysis (8)
- recombination (8)
- reproducibility (8)
- restoration (8)
- risk perception (8)
- rotation (8)
- sedimentary ancient DNA (8)
- site effects (8)
- snow (8)
- solar cells (8)
- spatial frequencies (8)
- stars: activity (8)
- stars: emission-line, Be (8)
- sustainable development (8)
- teaching quality (8)
- thermokarst (8)
- time-series (8)
- tracking (8)
- trends (8)
- trust (8)
- ultrafast (8)
- ventral striatum (8)
- verification (8)
- vitamin A (8)
- wh-questions (8)
- work (8)
- yellow flags (8)
- Abrüstung (7)
- Algeria (7)
- Anisotropy (7)
- Antike (7)
- Antisemitismus (7)
- Apoptosis (7)
- Aromaticity (7)
- BMI (7)
- Balance (7)
- Bewegung (7)
- Blockcopolymere (7)
- Botanik (7)
- Brasilien (7)
- C. elegans (7)
- CO2 (7)
- COVID-19 pandemic (7)
- Capsella (7)
- Clusteranalyse (7)
- Complex networks (7)
- Complexity (7)
- Crustal structure (7)
- Cytotoxicity (7)
- DNA damage (7)
- DNA radiation damage (7)
- Decision-making (7)
- Dekonstruktion (7)
- Democracy (7)
- Demokratisierung (7)
- Design (7)
- Deutschdidaktik (7)
- Diabetes (7)
- Digitale Plattformen (7)
- Dirac operator (7)
- Diskriminierung (7)
- Diskurs (7)
- Disturbance (7)
- East African Rift System (7)
- Egypt (7)
- Emulsion (7)
- Erziehungswissenschaften (7)
- Eurokrise (7)
- Eutrophication (7)
- Fokus (7)
- Forschendes Lernen (7)
- Forschungsreisen (7)
- Freiheit (7)
- Föderalismus (7)
- Führung (7)
- Geochemistry (7)
- Geopolitik (7)
- Georgien (7)
- Gesundheit (7)
- Global change (7)
- Greenland (7)
- Groundwater (7)
- Herrschaft (7)
- Hertzsprung-Russell and C-M diagrams (7)
- Higher education (7)
- Humboldt Digital Library (7)
- Humboldtian Science (7)
- Indian Summer Monsoon (7)
- Inspiration (7)
- Interaction (7)
- Interest (7)
- Interoception (7)
- Italien (7)
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- K-theory (7)
- Kalman filter (7)
- Kalter Krieg (7)
- Kiezdeutsch (7)
- Klimaschutz (7)
- Klimaänderung (7)
- Kompetenzen (7)
- Krieg (7)
- LCSM (7)
- Land use change (7)
- Landnutzung (7)
- Landschaftsmalerei (7)
- Landwirtschaft (7)
- Leadership (7)
- Leguminosae (7)
- Lehrer (7)
- LiDAR (7)
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- Magnetismus (7)
- Massenspektrometrie (7)
- Mekong Delta (7)
- Memory (7)
- Microtubules (7)
- Molecular dynamics (7)
- Molecularly imprinted polymers (7)
- Molybdenum cofactor (7)
- Mongolia (7)
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- Monsun (7)
- Mortality (7)
- Muscle strength (7)
- Musik (7)
- Musikunterricht (7)
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- Nutrients (7)
- O-antigen (7)
- PBPK (7)
- PUFA (7)
- Palaeoclimate (7)
- Paläoklimatologie (7)
- Palästina (7)
- Parteien (7)
- Perception (7)
- Phosphorus (7)
- Phylogeography (7)
- Polymerchemie (7)
- Polymers (7)
- Praxissemester (7)
- Prevalence (7)
- Professionsorientierung (7)
- Prozessmodellierung (7)
- Prunus avium L. (7)
- Pseudomonas aeruginosa (7)
- RIXS (7)
- Reading motivation (7)
- Recht (7)
- Regulierung (7)
- Remote sensing (7)
- Resistance training (7)
- Resozialisierung (7)
- Return to work (7)
- Rheologie (7)
- Risiko (7)
- Seasonality (7)
- Security Policy (7)
- Smalltalk (7)
- Soil moisture (7)
- Solanaceae (7)
- Sprachwandel (7)
- Sprachwissenschaft (7)
- Starch metabolism (7)
- Steuerung (7)
- Stickstoff (7)
- Survey (7)
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- Synthesis (7)
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- Südafrika (7)
- Tagebuch (7)
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- Thermokarst (7)
- Tien Shan (7)
- Time series analysis (7)
- Tolkien (7)
- Transfer (7)
- Twitter (7)
- Uncertainty (7)
- Unsicherheit (7)
- Unsicherheiten (7)
- Vegetation (7)
- Verwaltungsmodernisierung (7)
- Verwaltungsreform (7)
- Vietnamese (7)
- Vulnerabilität (7)
- Walking (7)
- Wasser (7)
- Water (7)
- Water quality (7)
- X-rays: ISM (7)
- Youth (7)
- Zinc (7)
- Zivilgesellschaft (7)
- academic achievement (7)
- acquisition (7)
- age of acquisition (7)
- aggregation (7)
- air pollution (7)
- algorithms (7)
- alignment (7)
- allostatic load (7)
- amygdala (7)
- anthropometry (7)
- arctic (7)
- articulation (7)
- augmented reality (7)
- autonomy (7)
- bias (7)
- binaries: eclipsing (7)
- biogenic amines (7)
- birth weight (7)
- business processes (7)
- bystander (7)
- calibration (7)
- catalogs (7)
- cellulose (7)
- change (7)
- charge generation (7)
- children and adolescents (7)
- circadian clock (7)
- circulation (7)
- circumstellar matter (7)
- cities (7)
- classical reception (7)
- climate-change mitigation (7)
- coastal erosion (7)
- cognitive development (7)
- colonialism (7)
- community ecology (7)
- complexes (7)
- computer games (7)
- conversation analysis (7)
- corruption (7)
- cortisol (7)
- cyber aggression (7)
- data (7)
- defense (7)
- density (7)
- depressive symptoms (7)
- developmental dyscalculia (7)
- dietary patterns (7)
- discrepancy principle (7)
- duplicate detection (7)
- dust (7)
- ecological modelling (7)
- ecosystem functioning (7)
- effectiveness (7)
- energy storage (7)
- ensemble Kalman filter (7)
- enzyme (7)
- enzyme catalysis (7)
- eutrophication (7)
- exercise therapy (7)
- extinction (7)
- extraction (7)
- extreme rainfall (7)
- fiction (7)
- first passage time (7)
- flood (7)
- floodplain (7)
- fluorescence correlation spectroscopy (7)
- food webs (7)
- function (7)
- functional magnetic resonance imaging (7)
- galaxies: dwarf (7)
- galaxies: starburst (7)
- gene flow (7)
- global warming (7)
- graphene (7)
- gravity (7)
- habitat (7)
- heart (7)
- heterogeneous catalysis (7)
- human behaviour (7)
- human impact (7)
- hydrolysis (7)
- ideology (7)
- imaging spectroscopy (7)
- income (7)
- infrared: stars (7)
- institutions (7)
- insula (7)
- international law (7)
- interoceptive awareness (7)
- isotopes (7)
- jumping (7)
- kardiologische Rehabilitation (7)
- kinematics (7)
- knowledge (7)
- land-use change (7)
- last glacial maximum (7)
- law (7)
- life history (7)
- lipid metabolism (7)
- low-energy electrons (7)
- magnetism (7)
- manifolds with singularities (7)
- memory retrieval (7)
- mental disorders (7)
- metaanalysis (7)
- metabolic networks (7)
- metaphor (7)
- miRNA (7)
- microbial ecology (7)
- microtubules (7)
- minerals (7)
- mixed methods (7)
- modern Jewish history (7)
- moment tensor (7)
- muscle (7)
- myocardial infarction (7)
- nanostructure (7)
- neotectonics (7)
- next generation sequencing (7)
- nitrogen deposition (7)
- nonergodicity (7)
- nucleus (7)
- number (7)
- numerical simulations (7)
- openHPI (7)
- organic matter (7)
- organic photovoltaics (7)
- orthography (7)
- oscillations (7)
- oxygen (7)
- pH (7)
- pain (7)
- palaeoecology (7)
- paleoecology (7)
- pandemic (7)
- parafoveal processing (7)
- parameter estimation (7)
- parents (7)
- pathogens (7)
- phase transition (7)
- phase transitions (7)
- phenomenology (7)
- photoelectron spectroscopy (7)
- planetary nebulae: general (7)
- planets and satellites: rings (7)
- plant diversity (7)
- plasmonics (7)
- plyometric training (7)
- pollution (7)
- polyelectrolytes (7)
- porous materials (7)
- predator-prey dynamics (7)
- presidential government (7)
- production (7)
- pronoun resolution (7)
- prosodic boundary cues (7)
- proteasome (7)
- protection (7)
- pseudodifferential operators (7)
- public sector (7)
- pulsars: general (7)
- quality (7)
- quantification (7)
- race (7)
- racism (7)
- reduction (7)
- repair (7)
- residual stress (7)
- retinol (7)
- rheology (7)
- roughness (7)
- scale development (7)
- screening (7)
- secular trend (7)
- sediment transport (7)
- seismic hazard (7)
- serotonin (7)
- shape-memory effect (7)
- sharing economy (7)
- silicon (7)
- size (7)
- soccer (7)
- social rejection (7)
- social support (7)
- socioeconomic status (7)
- software engineering (7)
- soil erosion (7)
- solar wind (7)
- sorption (7)
- spelling (7)
- stabile Isotope (7)
- standardization (7)
- stars: late-type (7)
- structure elucidation (7)
- sunspots (7)
- surfactants (7)
- surveillance (7)
- tVNS (7)
- taste (7)
- techniques: image processing (7)
- thermoresponsiv (7)
- thermoresponsive polymers (7)
- time series (7)
- tomato (7)
- tomography (7)
- tools (7)
- topography (7)
- treeline (7)
- trunk (7)
- ultrasound (7)
- uncertainty analysis (7)
- unemployment (7)
- uplift (7)
- urbanization (7)
- variation (7)
- vesicles (7)
- video analysis (7)
- wh-in-situ (7)
- working memory capacity (7)
- world literature (7)
- youth sports (7)
- Ästhetik (7)
- 1800 (6)
- 3D visualization (6)
- AFM (6)
- Absorption (6)
- Acceleration (6)
- Adhäsion (6)
- Ageing (6)
- Agency (6)
- Alaska (6)
- Alps (6)
- Anisotropy effect (6)
- Antibiotikaresistenz (6)
- Antikörper (6)
- Antwortmengenprogrammierung (6)
- Aristoteles (6)
- Arsenolipids (6)
- Atomwaffen (6)
- Aufmerksamkeit (6)
- Bakterien (6)
- Bayesian data analysis (6)
- Berühren (6)
- Bewegungsökologie (6)
- Bioelectrocatalysis (6)
- Biogenic amine (6)
- Blockcopolymer (6)
- Boden (6)
- Brief (6)
- C-reactive protein (6)
- Cardiovascular diseases (6)
- Caribbean (6)
- Centrosom (6)
- Chemotaxis (6)
- Chimborazo (6)
- Chloroplast (6)
- Chytridiomycota (6)
- Click chemistry (6)
- Climate Change (6)
- Computational modelling (6)
- Computerspiele (6)
- Copper (6)
- Daniel Kehlmann (6)
- Data assimilation (6)
- Deep learning (6)
- Deutschunterricht (6)
- Dielektrophorese (6)
- Digitale Medien (6)
- Disarmament (6)
- Diversity (6)
- Dynamic NMR (6)
- Dynamik (6)
- EEG/ERP (6)
- Effizienz (6)
- Ellenberg indicator values (6)
- Eltern (6)
- Emotions (6)
- Energy (6)
- Entzündung (6)
- Erinnerung (6)
- Ethics (6)
- Europäische Integration (6)
- Fachdidaktik Latein (6)
- Fachwissen (6)
- Flood (6)
- Flood risk (6)
- Fluorescence spectroscopy (6)
- Fremdsprachenunterricht (6)
- Gammastrahlungsastronomie (6)
- Gemeinsame Außen- und Sicherheitspolitik (6)
- Gene-environment interaction (6)
- Genomics (6)
- Georg Foster (6)
- Geowissenschaften (6)
- Geschmack (6)
- H II regions (6)
- HIREC (6)
- Hebrew (6)
- Hochschullehre (6)
- Hodge theory (6)
- Humboldt als Vorbild (6)
- Humboldt, Alexander von (6)
- Hypertension (6)
- ISM: kinematics and dynamics (6)
- Immigration (6)
- Immunoassay (6)
- Information (6)
- Inhaltsanalyse (6)
- Instructional quality (6)
- Insulin (6)
- Insurance (6)
- International Relations (6)
- Kenya (6)
- Klassifikation (6)
- Klimatologie (6)
- Kohlendioxid (6)
- Kosmologie (6)
- Kreativität (6)
- Lake Van (6)
- Language acquisition (6)
- Lasers (6)
- Latin (6)
- Lehre (6)
- Levy flights (6)
- Lipide (6)
- Local Group (6)
- Longitudinal (6)
- Luftverschmutzung (6)
- Lysiphlebus fabarum (6)
- Magnetohydrodynamik (6)
- Magnetotellurics (6)
- Magnetotellurik (6)
- Mandarin Chinese (6)
- Mannheimer Risikokinderstudie (6)
- Markov processes (6)
- Maschinen- und Anlagenbau (6)
- Mathematikunterricht (6)
- Measurement (6)
- Mecklenburg-Vorpommern (6)
- Menderes Massif (6)
- Mental arithmetic (6)
- Mental disorders (6)
- Meta-analysis (6)
- Metapher (6)
- Methane (6)
- Microarray (6)
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- Mobility (6)
- Movement ecology (6)
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- NCA (6)
- NE81 (6)
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- Neumann problem (6)
- Neuroenhancement (6)
- Neurotoxicity (6)
- Ontologie (6)
- Optimierung (6)
- Oxygen heterocycles (6)
- P300 (6)
- Paleoclimatology (6)
- Paleolimnology (6)
- Palestine (6)
- Peptid (6)
- Perceptual span (6)
- Perturbation (6)
- Perú (6)
- Phenotypic plasticity (6)
- Philologie (6)
- Phonons (6)
- Physikdidaktik (6)
- Poecilia mexicana (6)
- Population genetics (6)
- Potsdamer Lateintag (6)
- Pragmatik (6)
- Predictors (6)
- Prenatal stress (6)
- Professional development (6)
- Professionswissen (6)
- Pseudo-differential operators (6)
- Psychologie (6)
- Psychotherapie (6)
- Pyrenees (6)
- Python (6)
- Qualitätsmanagement (6)
- Quasare (6)
- R&D (6)
- RAFT polymerization (6)
- Raman (6)
- Reflexivität (6)
- Reinforcement learning (6)
- Reisetagebücher (6)
- Reliability (6)
- Rezeption (6)
- Rheology (6)
- Ring current effect (6)
- Romania (6)
- Ruthenium (6)
- SDS-PAGE (6)
- SWIM (6)
- Schadensmodellierung (6)
- School (6)
- Seesedimente (6)
- Selenium (6)
- Self-efficacy (6)
- Semantic Web (6)
- Sensorimotor training (6)
- Sentinel-1 (6)
- Sexual scripts (6)
- Sexual selection (6)
- Sexualität (6)
- Sibirien (6)
- Software (6)
- Soil erosion (6)
- Solanum tuberosum (6)
- Speech perception (6)
- Sphingosine 1-phosphate (6)
- Stable isotopes (6)
- Starkregen (6)
- Sternentwicklung (6)
- Storytelling (6)
- Strafrecht (6)
- Stretch-shortening cycle (6)
- Studium (6)
- Subduction zone processes (6)
- Svalbard (6)
- TMS (6)
- TRMM (6)
- Talmud (6)
- Taxonomy (6)
- Telerehabilitation (6)
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- Time reference (6)
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- Toeplitz operators (6)
- Topic (6)
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- Turbulenz (6)
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- University of Potsdam (6)
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- Variability (6)
- Variation (6)
- Vietnam (6)
- Wachstum (6)
- Wechsel (6)
- Weltbürger (6)
- West Bohemia (6)
- Westerlies (6)
- Wind erosion (6)
- Wissenschaft (6)
- Wissenschaftstheorie (6)
- Wissenstransfer (6)
- XPS (6)
- XRF (6)
- abstract concepts (6)
- acid ceramidase (6)
- admixture (6)
- alexithymia (6)
- amino acids (6)
- animal movement (6)
- antioxidants (6)
- apoptosis (6)
- architecture (6)
- assembly (6)
- behaviour (6)
- biodegradable polymers (6)
- biosensors (6)
- black holes (6)
- blockchain (6)
- body (6)
- bryophytes (6)
- capitalism (6)
- carbon sequestration (6)
- cartel (6)
- cell-free protein synthesis (6)
- change detection (6)
- chloroplast (6)
- climate mitigation (6)
- cluster analysis (6)
- co-limitation (6)
- collaboration (6)
- collective memory (6)
- collusion (6)
- community effect (6)
- constraints (6)
- contrast (6)
- coping (6)
- copolymers (6)
- corpus study (6)
- costs (6)
- crisis management (6)
- crown compounds (6)
- crystal-structure (6)
- cultural diversity (6)
- cultural studies (6)
- cyber victimization (6)
- cyber-physical systems (6)
- cytoskeleton (6)
- databases (6)
- design (6)
- development cooperation (6)
- diabetic nephropathy (6)
- dialogue (6)
- diffuse radiation (6)
- digital platforms (6)
- digitale Bildung (6)
- digitale Demokratie (6)
- domestication (6)
- droughts (6)
- dust, extinction (6)
- early warning (6)
- eclogite (6)
- ecohydrology (6)
- efficient (6)
- eicosapentaenoic acid (6)
- electrons (6)
- electrostatic interactions (6)
- elementary particles (6)
- ellipsometry (6)
- employment (6)
- engagement (6)
- english (6)
- entropy (6)
- environmental change (6)
- exoplanets (6)
- expertise (6)
- extension (6)
- eye movement (6)
- fNIRS (6)
- fabrication (6)
- facilitation (6)
- federalism (6)
- feminism (6)
- fertilization (6)
- financial markets (6)
- first passage (6)
- first-passage time (6)
- flooding (6)
- fluorescent dyes (6)
- foreland basin (6)
- formal semantics (6)
- galaxies: abundances (6)
- galaxy evolution (6)
- gamma-ray astronomy (6)
- gamma-rays: general (6)
- gas (6)
- gelatin (6)
- general relativity (6)
- genes (6)
- geodynamics (6)
- geology (6)
- givenness (6)
- giving-up density (6)
- global (6)
- glutathione peroxidase (6)
- grammar (6)
- habituation (6)
- heart rate variability (6)
- heat (6)
- heat stress (6)
- heterocycles (6)
- history and philosophy of astronomy (6)
- holocene (6)
- honey bee (6)
- honeybee (6)
- hybrid materials (6)
- hybridization capture (6)
- hydrogen (6)
- hydrologische Modellierung (6)
- impacts (6)
- implicit (6)
- indianische Kunst (6)
- infancy (6)
- infection (6)
- influenza (6)
- information (6)
- injury (6)
- interfaces (6)
- international relations (6)
- internet (6)
- intertextuality (6)
- introgression (6)
- invasive species (6)
- knowledge transfer (6)
- kosmische Strahlung (6)
- labour market (6)
- lanthanides (6)
- lifespan (6)
- ligand (6)
- light scattering (6)
- linagliptin (6)
- lithosphere (6)
- liver (6)
- logic (6)
- macrophytes (6)
- magnetic nanoparticles (6)
- mapping (6)
- maximal isometric Adaptive Force (6)
- mechanism (6)
- melt inclusions (6)
- mental simulation (6)
- metabolites (6)
- methods: analytical (6)
- micelles (6)
- microarray (6)
- microbial activity (6)
- microbial communities (6)
- microbial diversity (6)
- mind wandering (6)
- molecular modeling (6)
- molecular motors (6)
- molecular rods (6)
- multicore architectures (6)
- muscle power (6)
- nanoparticle (6)
- narration (6)
- negation (6)
- network analysis (6)
- neurodegeneration (6)
- neuromuscular control (6)
- neutron diffraction (6)
- new public management (6)
- nucleation (6)
- numerical development (6)
- optimization (6)
- organic semiconductors (6)
- p53 (6)
- palaeoclimate (6)
- parameters (6)
- pattern formation (6)
- perovskite (6)
- perpetrator (6)
- perturbation (6)
- phenology (6)
- phonetics (6)
- phosphate (6)
- phylogenetic diversity (6)
- picture naming (6)
- piezoelectricity (6)
- planning (6)
- plant (6)
- plants (6)
- political equality (6)
- polypeptide (6)
- polyphenols (6)
- polystyrene (6)
- polyzwitterions (6)
- population density (6)
- porosity (6)
- porous carbon (6)
- postural stability (6)
- pragmatics (6)
- predictability (6)
- preferential flow (6)
- pregnancy (6)
- presupposition (6)
- probiotics (6)
- process mining (6)
- professional knowledge (6)
- projections (6)
- protein adsorption (6)
- protein-protein interaction (6)
- quantum chemical calculations (6)
- questionnaire (6)
- radical polymerization (6)
- radiocarbon (6)
- rainfall (6)
- rampage (6)
- randomized controlled trial (6)
- rat (6)
- reciprocal class (6)
- reconstruction (6)
- relative index (6)
- reproduction (6)
- research projects (6)
- respiration (6)
- retinol-binding protein 4 (6)
- return to work (6)
- risk assessment (6)
- risk factor (6)
- saccades (6)
- salinity gradient (6)
- scattering (6)
- scrambling (6)
- sedaDNA (6)
- self-concept (6)
- self-healing (6)
- sensor (6)
- sensors (6)
- sex (6)
- silver nanoparticles (6)
- social comparison (6)
- sodium (6)
- software (6)
- software development (6)
- soil organic carbon (6)
- speciation (6)
- speed (6)
- star formation (6)
- stars: horizontal-branch (6)
- stars: kinematics and dynamics (6)
- stars: magnetic fields (6)
- state (6)
- stimuli-sensitive polymers (6)
- stochastic differential equations (6)
- stroke (6)
- structural equation modeling (6)
- sucrose (6)
- sulfite oxidase (6)
- support vector machine (6)
- surface relief grating (6)
- surgery (6)
- synchrotron radiation (6)
- tailspike protein (6)
- teacher (6)
- teachers (6)
- tendinopathy (6)
- thaliana (6)
- therapist competence (6)
- therapy (6)
- thermodynamics (6)
- tourism (6)
- trade-offs (6)
- training adaptation (6)
- traits (6)
- transcription (6)
- transcriptional memory (6)
- transcriptome (6)
- type 2 diabetes mellitus (6)
- typology (6)
- ultrafast dynamics (6)
- user experience (6)
- vesicle (6)
- visions of democracy (6)
- walking (6)
- water management (6)
- weight loss (6)
- young adults (6)
- zebrafish (6)
- öffentlicher Sektor (6)
- 19th century (5)
- 3D (5)
- 3D point clouds (5)
- AC electrokinetics (5)
- ALAN (5)
- Ackerschmalwand (5)
- Aesthetics (5)
- Affiliation (5)
- African Humid Period (5)
- Aftercare (5)
- Age of acquisition (5)
- Air pollution (5)
- Algorithmen (5)
- Allemagne (5)
- Alter (5)
- Alterung (5)
- Amygdala (5)
- Ancient DNA (5)
- Animal personality (5)
- Anisotropie (5)
- Antarktis (5)
- Arbeitsmarktpolitik (5)
- Arctic lakes (5)
- Arrayseismologie (5)
- Arsenic-containing hydrocarbons (5)
- Artificial Intelligence (5)
- Asian monsoon (5)
- Asteraceae (5)
- Atiyah-Patodi-Singer theory (5)
- Aufsatzsammlung (5)
- Authentizität (5)
- Autocorrelation (5)
- Baasdörper Krönk (5)
- Basketball (5)
- Bayesian inversion (5)
- Bayesian networks (5)
- Begrüßung (5)
- Behavior (5)
- Belarus (5)
- Beratung (5)
- Berufsorientierung (5)
- Bibliothek (5)
- Big Five (5)
- Bildung für nachhaltige Entwicklung (5)
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- Biodiversity exploratories (5)
- Biofilm (5)
- Bioinformatik (5)
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- Block copolymers (5)
- Blood (5)
- Bodenfeuchte (5)
- Body composition (5)
- Books (5)
- Boric acid (5)
- Boron exposure (5)
- Bose-Einstein condensation (5)
- Boundary value problems (5)
- Bourdieu (5)
- Brassicaceae (5)
- Bücher (5)
- Calcium (5)
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- Cayley Graph (5)
- Cell polarity (5)
- Cellulose (5)
- Child (5)
- Chitooligosaccharides (5)
- Classification (5)
- Cloud (5)
- Cluster (5)
- Cognition (5)
- Cognitive control (5)
- Columbus (5)
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- Community assembly (5)
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- Conservation (5)
- Cost-effectiveness (5)
- Costs (5)
- Covid-19 (5)
- Cue-based retrieval (5)
- Cultural diversity (5)
- Cyanobakterien (5)
- Cystic fibrosis (5)
- DNS (5)
- DRD4 (5)
- Data profiling (5)
- Datenassimilation (5)
- Datenqualität (5)
- Debugging (5)
- Decision making (5)
- Decomposition (5)
- Dexamethasone (5)
- Dictyostelium discoideum (5)
- Die Vermessung der Welt (5)
- Digital Humanities (5)
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- Diversität (5)
- Dopamin (5)
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- Eliten (5)
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- Embodiment (5)
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- Extremereignisse (5)
- Eye movement (5)
- Fallstudie (5)
- Feature selection (5)
- Fetal programming (5)
- Finanzmärkte (5)
- Fire-bellied toad (5)
- Flow cytometry (5)
- Flow-Erleben (5)
- Fluorescence imaging (5)
- Fluoreszenzmikroskopie (5)
- Fokker-Planck equation (5)
- Food quality (5)
- Frailty (5)
- Free Group (5)
- French (5)
- Functional ankle instability (5)
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- GABA (5)
- GPCR (5)
- Galaxy: center (5)
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- Geochemie (5)
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- German colonialism (5)
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- Gleichstellung (5)
- Glucose (5)
- Gold nanoparticles (5)
- Graph theory (5)
- Grassland (5)
- Grenzen (5)
- Ground reaction force (5)
- Grundwasser (5)
- HVSR (5)
- Habitat fragmentation (5)
- Heart rate variability (5)
- Heiner Müller (5)
- Hermeneutik (5)
- Heterocycles (5)
- Holding isometric muscle action (5)
- Humanismus (5)
- Humankapital (5)
- Humboldt und Hispanoamerika (5)
- IAT (5)
- IR-MALDI (5)
- ISM: jets and outflows (5)
- ISM: lines and bands (5)
- ISM: magnetic fields (5)
- Identitätsmanagement (5)
- Imaging (5)
- Immanuel Kant (5)
- Inclusion (5)
- Index (5)
- Individual-based models (5)
- Induced seismicity (5)
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- Insekten (5)
- Ionosphere (5)
- Janus emulsions (5)
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- Kompetenz (5)
- Korrosion (5)
- Kunst (5)
- Körper (5)
- L2 (5)
- L2 processing (5)
- LCST (5)
- LC–MS/MS (5)
- Labour market (5)
- Lactams (5)
- Lactones (5)
- Ladungstransport (5)
- Lakes (5)
- Land-use intensity (5)
- Landslides (5)
- Langmuir monolayer (5)
- Language production (5)
- Larix (5)
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- Mikroskopie (5)
- Mindfulness (5)
- Mitochondrial DNA (5)
- Moco biosynthesis (5)
- Modernization (5)
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- circular dichroism (4)
- cleft (4)
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- clone (4)
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- cod-liver (4)
- coefficient (4)
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- coevolution (4)
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- collagen (4)
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- common vole (4)
- community structure (4)
- compliance (4)
- computer science (4)
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- conceptualization (4)
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- conduct problems (4)
- conductivity (4)
- conflict (4)
- conflict management (4)
- confocal microscopy (4)
- content areas (4)
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- content-addressable memory (4)
- conversational agents (4)
- conversion (4)
- convolutional neural network (4)
- copper(II) (4)
- core (4)
- coreference (4)
- corpus linguistics (4)
- cosmic-ray neutron sensing (4)
- cosmology (4)
- coupling (4)
- covariance (4)
- creep (4)
- critical theory (4)
- crop (4)
- crop production (4)
- cross-cultural comparison (4)
- cross-curriculum (4)
- crosslinking (4)
- crust (4)
- cultural identity (4)
- cyberbullying victimization (4)
- cyberhate (4)
- cylindrospermopsin (4)
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- data mining (4)
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- debugging (4)
- decarbonization (4)
- definition (4)
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- deformation (4)
- degenerative disc disease (4)
- demography (4)
- deposition (4)
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- diachrony (4)
- diagnostic competence (4)
- diagnostics (4)
- dictator game (4)
- dictyostelium (4)
- differential operators (4)
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- digital sovereignty (4)
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- discourse production (4)
- distributed systems (4)
- diversification (4)
- dog (4)
- dropout (4)
- drought stress (4)
- drylands (4)
- dual-process (4)
- dyadic coping (4)
- dye (4)
- dye removal (4)
- dynamic capabilities (4)
- dynamical models (4)
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- eating behavior (4)
- eco-evolutionary experience (4)
- edge effect (4)
- effect (4)
- electron microscopy (4)
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- electrostatics (4)
- elliptic operator (4)
- emissions (4)
- emotional expression (4)
- emotional intelligence (4)
- employment policy (4)
- empowerment (4)
- emulsion polymerization (4)
- endophytes (4)
- endurance exercise (4)
- enhancement (4)
- entanglement (4)
- entrepreneurship education (4)
- environmental economics (4)
- environmental filtering (4)
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- errata, addenda (4)
- ethnic differences (4)
- ethnic identity (4)
- evaluative study (4)
- evaporites (4)
- event-related brain potentials (4)
- everyday life (4)
- evolutionary history (4)
- exchange (4)
- exercise intensity (4)
- expansion microscopy (4)
- experimental design (4)
- exploratory-behavior (4)
- extracellular matrix (4)
- eye-movement monitoring (4)
- face perception (4)
- family (4)
- fatty acid metabolism (4)
- fatty-acids (4)
- fault (4)
- faults (4)
- feature selection (4)
- fence ecology (4)
- ferroelectrets (4)
- ferroelectric polymers (4)
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- financial crisis (4)
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- finger counting (4)
- fire (4)
- first language acquisition (4)
- first-passage (4)
- fiscal federalism (4)
- fixation durations (4)
- flavonoid (4)
- floral scent (4)
- flower development (4)
- fluctuating light (4)
- fluid inclusions (4)
- focal adhesion (4)
- food choice (4)
- food neophilia (4)
- formal verification (4)
- forschendes Lernen (4)
- fractional dynamics (4)
- framework (4)
- frequency analysis (4)
- friendship (4)
- frustration (4)
- functional response (4)
- fundamental frequency (4)
- fungi (4)
- galaxies: star formation (4)
- garden-path effect (4)
- gaze-contingent displays (4)
- gene regulatory networks (4)
- genealogy (4)
- genetic diversity (4)
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- geography (4)
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- glutathione (4)
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- good governance (4)
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- graph transformation systems (4)
- graphs (4)
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- group field theory (4)
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- handwriting (4)
- hazard (4)
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- heart failure (4)
- helical magnetic fields (4)
- hemocompatibility (4)
- heterostyly (4)
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- historiography (4)
- holding capacity (4)
- holding isometric muscle action (HIMA) (4)
- hormones (4)
- human-computer interaction (4)
- hybrid (4)
- hybrid perovskites (4)
- hydrological modeling (4)
- hydrological models (4)
- hypoxia (4)
- ill-posed problem (4)
- imitation (4)
- immune system (4)
- immunology (4)
- implementation (4)
- implicit attitude (4)
- in vitro (4)
- in-service teacher training (4)
- individual (4)
- inertial measurement unit (4)
- inflammatory bowel disease (4)
- informatics (4)
- infrastructure (4)
- institutional reform (4)
- insulin signaling (4)
- interactional linguistics (4)
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- intrusion detection (4)
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- ionic strength (4)
- joint Simon effect (4)
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- karst (4)
- kernel methods (4)
- kidney (4)
- kidney transplantation (4)
- knickpoint (4)
- knowledge sharing (4)
- komplexe Systeme (4)
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- künstliche Intelligenz (4)
- lactate (4)
- land-use intensity (4)
- large-scale structure of Universe (4)
- laser pulses (4)
- left periphery (4)
- lexical access (4)
- lexicon (4)
- lichens (4)
- life satisfaction (4)
- lifetime income (4)
- light variability (4)
- line: identification (4)
- linear hypersubstitution (4)
- linear mixed models (4)
- lipidomics (4)
- literacy acquisition (4)
- loading rate (4)
- locomotion (4)
- locus coeruleus (4)
- locus of control (4)
- long-distance dispersal (4)
- low-back-pain (4)
- lower critical solution temperature (4)
- lutein (4)
- lutherische Theologie (4)
- machine (4)
- macrocycles (4)
- magnetostriction (4)
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- mammals (4)
- manifold with singularities (4)
- manufacturing (4)
- masculinity (4)
- mass (4)
- mathematics education (4)
- mathematics instruction (4)
- meadow (4)
- measurement invariance (4)
- mechanical tendinous oscillations (4)
- media use (4)
- memory effects (4)
- mesenchymal stem cells (4)
- mesoporous materials (4)
- metabolic engineering (4)
- metabolic regulation (4)
- metabolite (4)
- metadata (4)
- meteorological drought (4)
- methyl orange (4)
- methylene blue (4)
- methylmercury (4)
- miRNAs (4)
- micro-CT (4)
- microRNA (4)
- microlensing (4)
- micronutrients (4)
- mid-temperature transition (4)
- mild cognitive impairment (4)
- mitochondrial DNA (4)
- mitosis (4)
- mixtures (4)
- mobile links (4)
- model-driven engineering (4)
- modular production (4)
- molecular evolution (4)
- molecules (4)
- monoclonal antibody (4)
- mood (4)
- morality (4)
- morphogenesis (4)
- motivational interviewing (4)
- mowing (4)
- multilevel analysis (4)
- multivariate statistics (4)
- muscle oxygen saturation (4)
- museum specimens (4)
- music information retrieval (4)
- musikpädagogische Forschung (4)
- n-alkanes (4)
- nachhaltige Chemie (4)
- nanolenses (4)
- nanotriangles (4)
- national identity (4)
- naturalism (4)
- nature conservation (4)
- neoliberalism (4)
- nested graph conditions (4)
- network reconstruction (4)
- neurodegenerative diseases (4)
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- neuronal networks (4)
- neuroscience (4)
- neurotoxicity (4)
- neutrinos (4)
- new species (4)
- new technology (4)
- next generation sequencing (NGS) (4)
- nominalization (4)
- non-alcoholic fatty liver disease (4)
- non-linear dynamics (4)
- non-native speakers (4)
- non-photorealistic rendering (4)
- nonlinear operator (4)
- noun (4)
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- part 1 (4)
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- World War II (3)
- Wortstellung (3)
- Wärmetransport (3)
- X-ray imaging (3)
- XAS (3)
- XMCD (3)
- XRD (3)
- Yemen (3)
- YouTube (3)
- Young athletes (3)
- Yucatecan Spanish (3)
- Zahlentheorie (3)
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- Zink (3)
- Zionism (3)
- Zoologie (3)
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- [4+2] cycloaddition (3)
- ab initio (3)
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- aboveground biomass (3)
- absolute (3)
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- academic (3)
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- accessibility (3)
- accommodation (3)
- achievement (3)
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- actin cytoskeleton (3)
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- active layer (3)
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- additive Fertigung (3)
- adiposity (3)
- adolescent athletes (3)
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- adulthood (3)
- aerosols (3)
- affective priming (3)
- age differences (3)
- aggressive behavior (3)
- aggressive cognitions (3)
- aggressive peers (3)
- aging brain (3)
- aid effectiveness (3)
- air-water interface (3)
- albuminuria (3)
- allocation policies (3)
- ambient noise (3)
- amitriptyline (3)
- amperometry (3)
- analytics (3)
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- anatoxin (3)
- ancient sedimentary DNA (3)
- animal behaviour (3)
- annotation (3)
- antecedent complexity (3)
- anthracene (3)
- anthropogenic environment (3)
- anthropometric measures (3)
- anti-doping (3)
- anti-fouling materials (3)
- anti-gender (3)
- anti-humanism (3)
- antisemitism (3)
- aphasia treatment (3)
- apple (3)
- application (3)
- approach (3)
- aquaporin (3)
- arable land (3)
- area (3)
- argument mining (3)
- argumentation structure (3)
- artifical intelligence (3)
- artificial muscles (3)
- artificial neural networks (3)
- aspect (3)
- aspect ratio (3)
- assemblies (3)
- associative (3)
- asteroseismology (3)
- astrobiology (3)
- astrophotonics (3)
- asylum (3)
- asymmetry (3)
- asymptotic behavior (3)
- asymptotic expansion (3)
- atherosclerosis (3)
- athlete (3)
- atmospheric deposition (3)
- atmospheric effects (3)
- atomic force microscopy (AFM) (3)
- attentional control (3)
- attentional demand (3)
- attraction (3)
- auditory perception (3)
- autism (3)
- automatic processing (3)
- auxiliary control (3)
- auxotrophy (3)
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- bandgap (3)
- basal accretion (3)
- basic psychological need frustration (3)
- bat fatalities (3)
- batch processing (3)
- bats (3)
- batteries (3)
- benchmark (3)
- benefits (3)
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- berufliche Wiedereingliederung (3)
- beta-cell (3)
- bifurcation (3)
- bilinguals (3)
- bioactive peptides (3)
- bioavailability (3)
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- biological physics (3)
- biology (3)
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- bismuth (3)
- bitter taste (3)
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- blood (3)
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- bone (3)
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- bone remodeling (3)
- border (3)
- borders (3)
- bottom-up (3)
- boundary element method (3)
- boundary layer (3)
- boundary value problem (3)
- brain potentials (3)
- brassinosteroid (3)
- business process modeling (3)
- caffeine (3)
- calcite (3)
- cancer cachexia (3)
- cancer therapy (3)
- capillary recruitment (3)
- carbohydrate interaction (3)
- carbon budget (3)
- carbon dots (3)
- carbon pricing (3)
- carbon-cycle (3)
- carbonate (3)
- cardiomyopathy (3)
- caregiver (3)
- carotenoid (3)
- cartographic design (3)
- catalase (3)
- cell (3)
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- centralization (3)
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- chronic (3)
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- chronic diseases (3)
- chronic illness (3)
- ciliates (3)
- cilium (3)
- cis-regulatory evolution (3)
- citizen participation (3)
- civil service (3)
- classical solution (3)
- classical swine fever (3)
- clay (3)
- climate change impact (3)
- climate change mitigation (3)
- climate dynamics (3)
- climate networks (3)
- climate neutrality (3)
- climate services (3)
- cluster (3)
- co-creation (3)
- coatings (3)
- cockroach (3)
- cocoa processing (3)
- cocoa proteins (3)
- code (3)
- code generation (3)
- coercive strategies (3)
- coffee processing (3)
- cognitive behavioral therapy (3)
- cognitive bias (3)
- cognitive control (3)
- cognitive decline (3)
- cognitive impairment (3)
- cognitive module (3)
- cognitive performance (3)
- cognitive psychology (3)
- cognitive skills (3)
- cognitive-postural dual task (3)
- coherency (3)
- cohomology (3)
- coiled coil (3)
- cold (3)
- collective dynamics (3)
- collective guilt (3)
- collective team identification (3)
- college students (3)
- colon cancer (3)
- colorectal cancer (3)
- combat sport (3)
- comets: individual: 67P/Churyumov-Gerasimenko (3)
- community assembly (3)
- comorbidities (3)
- companies (3)
- comparative studies (3)
- compensatory dynamics (3)
- competence development (3)
- competitive growth (3)
- complementarity (3)
- complex (3)
- compounds (3)
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- computer graphics (3)
- concentration (3)
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- conditions (3)
- conduction (3)
- conference (3)
- confidence (3)
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- configuration (3)
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- congeneric species (3)
- conical singularities (3)
- conormal symbol (3)
- conscripts (3)
- conservation laws (3)
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- constraint (3)
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- consumption (3)
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- contact (3)
- content analysis (3)
- contestation (3)
- continental lithosphere (3)
- continuous time random walk (3)
- contrastive focus (3)
- controlled radical polymerization (3)
- coping styles (3)
- copolymerization (3)
- coronal mass ejections (CMEs) (3)
- coronary bypass grafting (3)
- corporate governance (3)
- corpus analysis (3)
- correlated noise (3)
- correlations (3)
- cost-benefit analysis (3)
- counting process (3)
- coupled oscillators (3)
- coupled rotators (3)
- course design (3)
- critical avalanche dynamics (3)
- critical phenomena (3)
- cross-domain priming (3)
- cross-lagged panel analysis (3)
- cross-methodological approach (3)
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- crowding (3)
- cryolithology (3)
- cryptic species (3)
- crystalline (3)
- cue validity (3)
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- curvature (3)
- cybervictimization (3)
- cyclic AMP (3)
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- damage modeling (3)
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- dark triad (3)
- data fusion (3)
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- decentralisation (3)
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- decline (3)
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- defense against predation (3)
- degraded DNA (3)
- dehydration (3)
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- democratisation (3)
- democratization (3)
- dendroclimatology (3)
- denitrification (3)
- density functional theory (3)
- denudation (3)
- dependence (3)
- dependency (3)
- depressive disorder (3)
- desensitization (3)
- design parameters (3)
- deutsche Geschichte (3)
- developmental dyslexia (3)
- diagnosis (3)
- dialectics (3)
- diamond anvil cell (3)
- dielectric relaxation spectroscopy (3)
- dietary quality (3)
- differential gene expression (3)
- diffraction (3)
- diffusing diffusivity (3)
- digital elevation model (3)
- digital interventions (3)
- digital media (3)
- digitale Souveränität (3)
- digitale Transformation (3)
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- disorders (3)
- dispersion (3)
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- early literacy (3)
- earthquake modeling (3)
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- elite athlete (3)
- embedded systems (3)
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- emerging adults (3)
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- emotional valence (3)
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- encoding (3)
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- fMRT (3)
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- facial feedback (3)
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- faking (3)
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- forecast (3)
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- frameworks (3)
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- functional (3)
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- fungal diversity (3)
- gait analysis (3)
- galaxies: fundamental parameters (3)
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- garnet (3)
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- gender gap (3)
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- gender wage gap (3)
- gene duplication (3)
- gene family (3)
- gene regulatory network (3)
- general (3)
- generalizability (3)
- generalization (3)
- genetic programming (3)
- genome assembly (3)
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- genotype (3)
- geodynamic modeling (3)
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- geostatistics (3)
- gesture (3)
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- glucocorticoid receptor (3)
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- information technology (3)
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- kana (3)
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- kollektives Gedächtnis (3)
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- labeling (3)
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- matching (3)
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- net ecosystem exchange (3)
- neural (3)
- neurofeedback (3)
- neuromuscular adaptation (3)
- neuromuscular functionality (3)
- neutral endopeptidase (3)
- neutron (3)
- neutron reflectometry (3)
- niche and fitness differences (3)
- niche width (3)
- nichtlineare Optik (3)
- nineteenth century (3)
- nitrogen limitation (3)
- noisy systems (3)
- non-Langevin recombination (3)
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- non-athletes (3)
- non-categoricity (3)
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- nonstationarity (3)
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- octopamine (3)
- offspring (3)
- oil palm (3)
- older patients (3)
- olivine (3)
- omega-3 fatty acids (3)
- on-water performance (3)
- one-carbon metabolism (3)
- online course (3)
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- open (3)
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- origin (3)
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- oxygen isotopes (3)
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- palaeolimnology (3)
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- paper (3)
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- planets and satellites: individual (Saturn) (3)
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- poly(A) polymerase (3)
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- rearrangement (3)
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- reception (3)
- reciprocal processes (3)
- recommendations (3)
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- reductase (3)
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- refinement (3)
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- resolution (3)
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- stars: (3)
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- ) (2)
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- 1 (2)
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Umweltbildung im Cyberspace
(1999)
Naturliebe per Knopfdruck
(1999)
100 Jahre NABU
(1999)
Zur Nahrungswahl der Schleiereule (Tyto alba guttata) im Landkreis Potsdam-Mittelmark (Brandenburg)
(1998)
Due to its relevance for global climate, the realistic representation of the Atlantic meridional overturning circulation (AMOC) in ocean models is a key task. In recent years, two paradigms have evolved around what are its driving mechanisms: diapycnal mixing and Southern Ocean winds. This work aims at clarifying what sets the strength of the Atlantic overturning components in an ocean general circulation model and discusses the role of spatially inhomogeneous mixing, numerical diffusion and winds. Furthermore, the relation of the AMOC with a key quantity, the meridional pressure difference is analyzed. Due to the application of a very low diffusive tracer advection scheme, a realistic Atlantic overturning circulation can be obtained that is purely wind driven. On top of the winddriven circulation, changes of density gradients are caused by increasing the parameterized eddy diffusion in the North Atlantic and Southern Ocean. The linear relation between the maximum of the Atlantic overturning and the meridional pressure difference found in previous studies is confirmed and it is shown to be due to one significant pressure gradient between the average pressure over high latitude deep water formation regions and a relatively uniform pressure between 30°N and 30°S, which can directly be related to a zonal flow through geostrophy. Under constant Southern Ocean windstress forcing, a South Atlantic outflow in the range of 6-16 Sv is obtained for a large variety of experiments. Overall, the circulation is winddriven but its strength not uniquely determined by the Southern Ocean windstress. The scaling of the Atlantic overturning components is linear with the background vertical diffusivity, not confirming the 2/3 power law for one-hemisphere models without wind forcing. The pycnocline depth is constant in the coarse resolution model with large vertical grid extends. It suggests the ocean model operates like the Stommel box model with a linear relation of the pressure difference and fixed vertical scale for the volume transport. However, this seems only valid for vertical diffusivities smaller 0.4 cm²/s, when the dominant upwelling within the Atlantic occurs along the boundaries. For larger vertical diffusivities, a significant amount of interior upwelling occurs. It is further shown that any localized vertical mixing in the deep to bottom ocean cannot drive an Atlantic overturning. However, enhanced boundary mixing at thermocline depths is potentially important. The numerical diffusion is shown to have a large impact on the representation of the Atlantic overturning in the model. While the horizontal numerical diffusion tends to destabilize the Atlantic overturning the verital numerical diffusion denotes an amplifying mechanism.
Vor- und nacheiszeitliche Großtierformen in Mitteleuropa und ihre Einpassung in das Ökosystem
(1997)
Durch die anthropogene Nutzung sind viele Auen in Mitteleuropa verändert worden, wobei insbesondere die Retentionsflächen stark verringert wurden. Während Auen seit längerem im Fokus der wissenschaftlichen Bearbeitung stehen, gibt es bisher große Wissensdefizite in der Frage der Auenreaktivierungen. Zum einen sind derartige Projekte bisher kaum verwirklicht und zum anderen ist ein langfristiges Monitoring notwendig, um die Anpassung von Biozönosen an die veränderten Standortbedingungen beobachten zu können. Um die Folgen derartiger Eingriffe zu analysieren, bieten sich computergestützte Modellierungen der Landschaftsentwicklung an, wie sie in der vorliegenden Arbeit verwirklicht wurden. Ziel der Arbeit war, mit Hilfe eines Geografischen Informationssystems (GIS) das Entwicklungspotenzial der Landschaft bei verschiedenen Rückdeichungsvarianten auf der Ebene der Biotoptypen darzustellen. Dabei ging es nicht um die Erstellung eines allgemein gültigen Auenmodells sondern um die Erarbeitung eines Modells für einen konkreten Anwendungsfall. Der erarbeitete Ansatz sollte zudem für die landschaftsplanerische Praxis geeignet sein. Als Beispielgebiete wurden Flächen an der Mittleren Elbe bei Rogätz und Sandau, beide im nördlichen Teil von Sachsen-Anhalt, ausgewählt. Die vorliegende Arbeit gliedert sich in zwei Teile. Im ersten Teil werden Erhebungen und Auswertungen als Grundlage der Modellentwicklung dargestellt. Dazu wurden die Biotoptypen der Beispielgebiete flächendeckend erhoben und mit punktuellen Vegetationserhebungen ergänzt. Aus dem Forschungsprojekt "Rückgewinnung von Retentionsflächen und Altauenreaktivierung an der Mittleren Elbe in Sachsen-Anhalt" des Bundesministeriums für Bildung und Forschung (BMBF) standen standortökologische Daten der Hydrologie und Bodenkunde zur Verfügung. Ziel der Auswertung war, Schlüsselfaktoren für Hydrologie und Bodenbedingungen innerhalb der rezenten Aue zu identifizieren, die zur Ausprägung bestimmter Biotoptypen führen. Im zweiten Teil der Arbeit wurde ein Modell für Biotoptypenpotenziale auf den geplanten Rück–deichungsflächen entwickelt. Das Modell bearbeitet die Datenbank der verwendeten GIS-Dateien, die auf Daten zum Bestand beruht und um solche der Prognose der Standortökologie (Hydrologie und Boden) im Rückdeichungsfalle aus dem BMBF-Projekt erweitert wurde. Weitere Voraussetzung für die Modellierung war die Erarbeitung von Leitbildern, in denen unterschiedliche Nutzungsszenarios für die Landschaft nach Deichrückverlegung hypothetisch festgelegt wurden. Insbesondere die Nutzungsintensität wurde variiert, von einer Variante intensiver land- und forstwirtschaftlicher Nutzung über sogenannte integrierte Entwicklungsziele aus dem BMBF-Projekt bis hin zu einer Variante der Naturschutznutzung. Zusätzlich wurde eine zukünftige Potentielle Natürliche Vegetation modelliert. Eine Überprüfung des Modell fand für den Raum der rezenten Aue in der intensiven Nutzungsvariante statt, die der gegenwärtigen Nutzung am nächsten kommt. Werden Informationen des Bestandsbiotoptyps als Korrekturgröße in das Modell einbezogen, konnte für viele Biotoptypen eine Trefferquote von über 90 % erreicht werden. Bei flächenmäßig weniger bedeutenden Bio–toptypen lag dieser Wert aufgrund der schmaleren Datenbasis zwischen 20 und 40 %. Als Ergebnis liegt für unterschiedliche Deichvarianten und Leitbilder in den Beispielgebieten die Landschaftsentwicklung als Biotoppotenzial vor. Als eine vereinfachte Regionalisierung der punktuellen Vegetationsdaten wurde im Modell geprüft, inwieweit die modellierten Biotopflächen der Charakteristik der pflanzensoziologischen Aufnahmen aus der rezenten Aue entsprechen. In dem Falle wurde die Pflanzengesellschaft der jeweiligen ökologisch im Rahmen der Untersuchung einheitlichen Flächeneinheit zugeordnet. Anteilig lässt sich damit die Biotopprognosefläche pflanzensoziologisch konkretisieren. Die vorliegende Arbeit gehört zu den bisher wenigen Arbeiten, die sich mit den Folgen von Auenreaktivierung auf die Entwicklung der Landschaft auseinandersetzen. Sie zeigt eine Möglichkeit auf, Prognosemodelle für Biotoptypen und Vegetation anhand begrenzter Felduntersuchungen zu entwerfen. Derartige Modelle können zum Verständnis von Eingriffen in den Naturhaushalt, wie sie die Deichrückverlegungen darstellen, beitragen und eine Folgenabschätzung unterstützen.
Im Mittelpunkt dieser Arbeit standen Signaltransduktionsprozesse in den Strukturen der Kraftübertragung quergestreifter Muskelzellen, d. h. in den Costameren (Zell-Matrix-Kontakten) und den Glanzstreifen (Zell-Zell-Kontakten der Kardiomyozyten).Es ließ sich zeigen, dass sich die Morphologie der Zell-Matrix-Kontakte während der Differenzierung von Skelettmuskelzellen dramatisch ändert, was mit einer veränderten Proteinzusammensetzung einhergeht. Immunfluoreszenz-Analysen von Skelettmuskelzellen verschiedener Differenzierungsstadien implizieren, dass die Signalwege, welche die Dynamik der Fokalkontakte in Nichtmuskelzellen bestimmen, nur für frühe Stadien der Muskeldifferenzierung Relevanz haben können. Ausgehend von diesem Befund wurde begonnen, noch unbekannte Signalwege zu identifizieren, welche die Ausbildung von Costameren kontrollieren: In den Vorläuferstrukturen der Costamere gelang es, eine transiente Interaktion der Proteine Paxillin und Ponsin zu identifizieren. Biochemische Untersuchungen legen nahe, dass Ponsin über eine Skelettmuskel-spezifische Insertion im Carboxyterminus das Adapterprotein Nck2 in diesen Komplex rekrutiert. Es wird vorgeschlagen, dass die drei Proteine einen ternären Signalkomplex bilden, der die Umbauvorgänge der Zell-Matrix-Kontakte kontrolliert und dessen Aktivität von mitogen activated protein kinases (MAPK) reguliert wird.Die Anpassungsvorgänge der Strukturen der Kraftübertragung an pathologische Situtation (Kardiomyopathien) in der adulten quergestreiften Muskulatur wurden ausgehend von einem zweiten Protein, dem muscle LIM protein (MLP), untersucht. Es konnte gezeigt werden, dass ein mutiertes MLP-Protein, das im Menschen eine hypertrophe Kardiomyopathie (HCM) auslöst, strukturelle Defekte aufweist und weniger stabil ist. Weiterhin zeigte dieses mutierte Protein eine verringerte Bindungsfähigkeit an die beiden Liganden N-RAP und alpha-Actinin. Die molekulare Grundlage der HCM-verursachenden Mutationen im MLP-Gen könnte folglich eine Veränderung der Homöostase im ternären Komplex MLP – N-RAP – alpha-Actinin sein. Die Expressionsdaten eines neu generierten monoklonalen MLP-Antikörpers deuten darauf hin, dass die Funktionen des MLP nicht nur für die Integrität des Myokards, sondern auch für die der Skelettmuskulatur notwendig sind.
Für das Verständnis der Strukturbildung bei Proteinen ist es wichtig, allgemein geltende Prinzipien der Stabilität und Faltung zu verstehen. Bisher wurde viel Arbeit in die Erörterung von Gesetzmäßigkeiten zu den Faltungseigenschaften von globulären Proteinen investiert. Die große Proteinklasse der solenoiden Proteine, zu denen z. B. Leucine-Rich Repeat- (LRR-) oder Ankyrin-Proteine gehören, wurde dahingegen noch wenig untersucht. Die Proteine dieser Klasse sind durch einen stapelförmigen Aufbau von sich wiederholenden typischen Sequenzeinheiten gekennzeichnet, was in der Ausbildung einer elongierten Tertiärstruktur resultiert. In der vorliegenden Arbeit sollte versucht werden, die Stabilität und Faltung eines LRR-Proteins mittels verschiedener biophysikalischer Methoden zu charakterisieren. Als Untersuchungsobjekt diente die für die Infektion ausreichende zentrale LRR-Domäne des Invasionsproteins Internalin B (InlB241) des Bakteriums Listeria monocytogenes. Des weiteren sollten die Integrität und die Stabilitäts- und Faltungseigenschaften der sogenannten Internalin-Domäne (InlB321) untersucht werden. Hierbei handelt es sich um die bei allen Mitgliedern der Internalinfamilie vorkommende Domäne, welche aus einer direkten Fusion des C-terminalen Endes der LRR-Domäne mit einer Immunglobulin (Ig)-ähnlichen Domäne besteht. Von beiden Konstrukten konnte eine vollständige thermodynamische Charakterisierung, mit Hilfe von chemisch- bzw. thermisch-induzierten Faltungs- und Entfaltungsübergängen durchgeführt werden. Sowohl InlB241 als auch InlB321 zeigen einen reversiblen und kooperativen Verlauf der chemisch-induzierten Gleichgewichtsübergänge, was die Anwendung eines Zweizustandsmodells zur Beschreibung der Daten erlaubte. Die zusätzliche Ig-ähnliche Domäne im InlB321 resultierte im Vergleich zum InlB241 in einer Erhöhung der freien Enthalpie der Entfaltung (8.8 kcal/mol im Vergleich zu 4.7 kcal/mol). Diese Stabilitätszunahme äußerte sich sowohl in einer Verschiebung des Übergangsmittelpunktes zu höheren Guanidiniumchlorid-Konzentrationen als auch in einer Erhöhung der Kooperativität des Gleichgewichtsübergangs (9.7 kcal/mol/M im Vergleich zu 7.1 kcal/mol/M). Diese Beobachtungen zeigen dass die einzelnen Sequenzeinheiten der LRR-Domäne nicht unabhängig voneinander falten und dass die Ig-ähnliche Domäne, obwohl sie nicht direkt mit dem Wirtszellrezeptor während der Invasion interagiert, eine kritische Rolle für die <i style='mso-bidi-font-style:normal'>in vivo Stabilität des Internalin B spielt. Des weiteren spiegelt die Kooperativität des Übergangs die Integrität der Internalin-Domäne wieder und deutet darauf hin, dass bei beiden Proteinen keine Intermediate vorliegen. Kinetische Messungen über Tryptophanfluoreszenz und Fern-UV<span style='color:red'> </span>Circulardichroismus deuteten auf die Existenz eines relativ stabilen Intermediates auf dem Faltungsweg der LRR-Domäne hin. Faltungskinetiken aus einem in pH 2 denaturierten Zustand zeigten ein reversibles Verhalten und verliefen über ein Intermediat. Eine Erhöhung der Salzkonzentration des sauer-denaturierten Proteins führte zu einer Kompaktierung der entfalteten Struktur und resultierte im Übergang zu einem alternativ gefalteten Zustand. Bei der Internalin-Domäne deuteten kinetische Messungen des Fluoreszenz- und Fern-UV Circulardichroismus-Signals während der Entfaltung möglicherweise auf die Präsenz von zwei Prozessen hin. Der erste langsame Entfaltungsprozess kurz nach dem Übergangsmittelpunkt zeigte eine starke Abhängigkeit von der Temperatur, während der zweite schnellere Prozess der Entfaltung stärker von der Guanidiniumchlorid-Konzentration abhing. Renaturierungskinetiken zeigten das Auftreten von mindestens einem Faltungsintermediat. Kinetische Daten aus Doppelsprungexperimenten lieferten für die Erklärung der langsamen Faltungsphase zunächst keinen Hinweis auf dass Vorliegen einer Prolinisomerisierungsreaktion. Die vollständige Amplitude während der Renaturierung konnte nicht detektiert werden, weswegen von einer zweiten schnellen Phase im Submillisekundenbereich ausgegangen werden kann. Die Ergebnisse der Faltungskinetiken zeigen, dass die InlB-Konstrukte als Modelle für die Untersuchung der Faltung von Solenoidproteinen verwendet werden können.<span lang=EN-GB style='mso-ansi-language: EN-GB'><o:p></o:p></span>
Charakterisierung von ausgewählten Protein-Phosphatasen und MATE-Proteinen aus Arabidopsis thaliana
(2004)
Im ersten Teil der vorliegenden Arbeit wurde die Genexpression der Protein Phosphatase-gene TOPP1, TOPP2, TOPP5, STH1 und STH2 analysiert. Alle fünf ausgewählten Gene kodieren für PP des PP1/PP2A-Typs. Es wurde untersucht, ob homologen PP-Isoformen individuelle Expressionsmuster zugewiesen werden konnten. Besonderes Augenmerk richtete sich dabei auf die Expression von PP-Genen in den Schließzellen von A. thaliana. In mehreren Inhibitorstudien wurde beschrieben, dass PP1/PP2A-Proteine eine wichtige Rolle in der Signaltransduktion pflanzlicher Schließzellen spielen. Bisher konnte allerdings noch keine der entsprechenden katalytischen Untereinheiten auf molekularer Ebene identifiziert werden. Im Rahmen dieser Arbeit wurde zum ersten Mal nachgewiesen, dass mit TOPP1 ein Protein des PP1-Typs präferenziell in den Schließzellen von A. thaliana exprimiert wird. Ein Vergleich der Genexpression von TOPP1, TOPP2 und TOPP5 zeigte für die drei homologen Gene sehr Isoform-spezifische Expressionsmuster. Dies war ein deutlicher Hinweis, dass diese eng verwandten PP trotz großer Übereinstimmung auf Aminosäureebene vermutlich unterschiedliche Funktionen in planta haben. Die Untersuchung der Genexpression von STH1 und STH2 zeigte, dass die fast identischen Proteine zum Teil in unterschiedlichen Geweben vorkommen. Die Transkripte der beiden Gene, welche eine eigene Untergruppe von PP2A-verwandten Sequenzen bilden, konnten aus EF isoliert werden. Der in dieser Arbeit entwickelte Screeningansatz ermöglichte es, die sehr ähnlichen cDNA-Fragmente eindeutig voneinander zu unterscheiden. Die gefundenen Isoform-spezifischen Expressionsmuster waren ein deutlicher Hinweis auf unterschiedliche Funktionen in planta. Zur weiteren Untersuchung der PP-Funktionen in planta wurden Pflanzen mit veränderter Genaktivität von TOPP2 oder STH1 untersucht. In Pflanzen mit RNAi-vermittelter Reduktion des TOPP2-Transkriptgehalts ließ sich ein deutlich verändertes Blattwachstum beobachten. Die eingerollten oder asymmetrisch entwickelten Blätter waren vermutlich ein Hinweis, dass diese PP1-Isoform auch in A. thaliana eine Rolle bei der Zellteilung spielt. Für TOPP2-Expression in Hefen wurde diese Funktion schon nachgewiesen. Die Analyse von Insertions-mutanten mit T-DNA Insertionen in beiden STH1-Allelen waren neben den Expressions-studien ein weiterer Hinweis, dass sich STH1 nicht funktionell durch STH2 ersetzen lässt. Die Experimente in dieser Arbeit zeigten, dass das Fehlen der STH1-Genaktivität zu einem deutlichen Blattphänotyp mit gezahnten Blatträndern führte. Für STH2-Insertionsmutanten wurde dieses veränderte Wachstum nicht beschrieben. Im zweiten Teil dieser Arbeit wurde das Gen NIC1, welches für ein MATE-Membranprotein kodiert, identifiziert und charakterisiert. Die Sequenzierung des Genoms von A. thaliana hatte gezeigt, dass mindestens 56 MATE-Gene in dieser Pflanze vorhanden sind. Zum Zeitpunkt der Identifikation von NIC1 war keines dieser Gene charakterisiert. Außer für das MATE-Protein ERC1 aus S. cerevisiae gab es keine Studien zu eukaryotischen Mitgliedern dieser großen Familie von Membranproteinen. Anhand NIC1 wurden heterologe Expressionssysteme zur funktionellen Charakterisierung von MATE-Proteinen aus Pflanzen etabliert. Die cDNA von NIC1 wurde nach ihrer Klonierung in X. laevis Oozyten und S. cerevisiae exprimiert. In S. cerevisiae erhöhte die NIC1-Expression die Lithumtoleranz der Hefen und führte zu einer Verminderung der Natriumtoleranz. Parallele Versuche mit NIC2 und NIC4 (in den Diplomarbeiten von Blazej Dolniak und Mandy Kursawe) zeigten, dass auch diese beiden Proteine die Salztoleranz von S. cerevisiae beeinflussten. Während NIC2 die Lithium- und Natriumtoleranz erhöhte, führte NIC4-Expresion zu einer höheren Sensibilität gegenüber diesen beiden Kationen. Die unterschiedlichen Eigenschaften der drei homologen Proteine zeigten sich auch bei ihrer Expression in X. laevis Oozyten. NIC1 induzierte in den Oozyten auswärts gerichtete Chloridströme, die spannungsabhängig waren und durch mikromolare Konzentrationen der trivalenten Kationen Lanthan oder Gadolinium inhibiert werden konnten. NIC4 induzierte Barium-inhibierbare Kaliumströme, die spannungsunabhängig waren. Für NIC2 ließ sich in diesem Expressionssystem keine Aktivität detektieren. Zur Untersuchung der NIC1-Funktion in planta wurde die Genaktivität in transgenen Pflanzen lokalisiert und reduziert. Die NIC1-Genexpression war hauptsächlich in den vaskulären Geweben der Pflanze detektierbar und einer Verminderung des NIC1-Transkriptgehalts beeinflusste die Entwicklungsgeschwindigkeit der Pflanzen. Sie entwickelten sich deutlich langsamer als der parallel kultivierte Wildtyp. Der deutliche Phänotyp bei Veränderung der Genaktivität von nur einem der mindestens 56 vorhandenen MATE-Gene in A. thaliana zeigte, dass vermutlich keine weitere MATE-Isoform in der Lage ist, die Funktion von NIC1 zu übernehmen.
In dieser Arbeit wird ein chemisches Abgussverfahren für selbstorganisierte Strukturen in Lösung verwendet, das es ermöglicht definierte poröse Materialien mit Strukturierung auf der Nanometerskala herzustellen. Ähnlich wie beim Gussverfahren von Werkstücken wird die Vorlage durch ein geeignetes Material abgebildet. Durch Entfernen dieser Vorlage erhält man ein poröses (mit Hohlräumen durchsetztes) Negativ derselben. Die auf diese Weise erhaltenen Materialien sind in mehrerer Hinsicht interessant: So lassen sich aus ihrer Morphologie Rückschlüsse über die Natur der selbstorganisierten Strukturen erhalten, da der hier verwendete Abbildungsprozess selbst kleinste strukturelle Details erfasst. Die Hohlräume der synthetisierten porösen Stoffe hingegen können als winzige Reaktionsgefäße, sogenannte "Nano-Reaktoren" verwendet werden. Dies ermöglicht sowohl die Synthese von Nano-Partikeln, die auf anderem Wege nicht zugänglich sind, als auch die Möglichkeit Einflüsse der räumlichen Restriktion auf die Reaktion zu untersuchen. Besonders räumlich ausgedehnte Strukturen sollten hierbei Auffälligkeiten zeigen. Somit ist die Gliederung der Arbeit vorgegeben: - Die Herstellung und Charakterisierung von porösen Stoffen und selbstorganisierten Strukturen - Ihre Verwendung als "Nano-Reaktor"
Neue Einflüsse und Anwendungen von Mikrowellenstrahlung auf Miniemulsionen und ihre Kompositpolymere
(2004)
Miniemulsionen bestehen aus zwei miteinander nicht mischbaren Flüssigkeiten, von der die eine in Form kleiner Tröpfchen fein in der anderen verteilt (dispergiert) ist. Miniemulsionströpfchen sind mit Durchmessern von ungefähr 0,1 Mikrometer kleiner als herkömmliche Emulsionen und können u. a. als voneinander unabhängige Nanoreaktoren für chemische Reaktionen verwendet werden. Man unterteilt sie in direkte Miniemulsionen, in denen ein Öl in Wasser dispergiert ist, und inverse Miniemulsionen, in denen Wasser in Öl dispergiert wird. In dieser Arbeit wird das besondere chemische und physikalische Verhalten solcher Miniemulsionen unter dem Einfluß von Mikrowellenstrahlung untersucht. Dabei werden sowohl für Öl-in-Wasser als auch für Wasser-in-Öl-Miniemulsionen grundlagenwissenschaftliche Entdeckungen beschrieben und durch neue Modelle erklärt. Der praktische Nutzen dieser bislang unbeschriebenen Effekte wird durch ingenieurwissenschaftliche Anwendungsbeispiele im Bereich der Polymerchemie verdeutlicht. 1. Polymerisation mit "überlebenden Radikalen" (Surviving Radical Polymerization) Für die Herstellung von sog. Polymerlatizes (Kunststoffdispersionen, wie sie u. a. für Farben verwendet werden) aus direkten Styrol-in-Wasser Miniemulsionen werden die Styroltröpfchen als Nanoreaktoren verwendet: Sie werden mit Hilfe von Radikalen durch eine Kettenreaktion zu winzigen Polymerpartikeln umgesetzt, die im Wasser dispergiert sind. Ihre Materialeigenschaften hängen stark von der Kettenlänge der Polymermoleküle ab. In dieser Arbeit konnten durch den Einsatz von Mikrowellenstrahlung erstmals große Mengen an Radikalen erzeugt werden, die jeweils einzeln in Tröpfchen (Nanoreaktoren) auch noch lange Zeit nach dem Verlassen der Mikrowelle überleben und eine Polymerisationskettenreaktion ausführen können. Diese Methode ermöglicht nicht nur die Herstellung von Polymeren in technisch zuvor unerreichbaren Kettenlängen, mit ihr sind auch enorm hohe Umsätze nach sehr kurzen Verweilzeiten in der Mikrowelle möglich – denn die eigentliche Reaktion findet außerhalb statt. Es konnte gezeigt werden, dass durch Einsatz von Zusatzstoffen bei unvermindert hohem Umsatz die Polymerkettenlänge variiert werden kann. Die technischen Vorzüge dieses Verfahrens konnten in einer kontinuierlich betriebenen Pilotanlage nachgewiesen werden. 2. Aufheizverhalten inverser Miniemulsionen in Mikrowellenöfen Das Aufheizverhalen von Wasser-in-Öl Miniemulsionen mit kleinen Durchmessern durch Mikrowellen ist überaus träge, da sich nur das wenige Wasser in den Tröpfchen mit Mikrowellen aufheizen lässt, das Öl jedoch kaum. Solche Systeme verhalten sich gemäß der "Theorie des effektiven Mediums". Werden aber etwas größere Tröpfchen im Mikrometerbereich Mikrowellen ausgesetzt, so konnte eine wesentlich schnellere Aufheizung beobachtet werden, die auf eine Maxwell-Wagner-Grenzflächenpolarisation zurückgeführt werden kann. Die Größenabhängigkeit dieses Effekts wurde mit Hilfe der dielektrischen Spektroskopie quantifiziert und ist bislang in der Literatur nie beschrieben worden. Zur genauen Messung dieses Effekts und zu seiner technischen Nutzung wurde ein neuartiges Membranverfahren für die Herstellung von großen Miniemulsionströpfchen im Mikrometerbereich entwickelt. 3. Herstellung von Kompositpolymeren für Mikrowellenanwendungen Um die untersuchte Maxwell-Wagner-Grenzflächenpolarisation technisch nutzen zu können, wurden als dafür geeignete Materialien Kompositpolymere hergestellt. Das sind Kunststoffe, in denen winzige Wassertropfen oder Keramikpartikel eingeschlossen sind. Dazu wurden neuartige Synthesewege auf der Grundlage der Miniemulsionstechnik entwickelt. Ihr gemeinsames Ziel ist die Einschränkung der üblicherweise bei Polymerisation auftretenden Entmischung: In einem Verfahren wurde durch Gelierung die Beweglichkeit der emulgierten Wassertröpfchen eingeschränkt, in einem anderen wurde durch das Einschließen von Keramikpartikeln in Miniemulsionströpfchen die Entmischung auf deren Größe beschränkt. Anwendungen solcher Kompositpolymere könnten künstliche Muskeln, die Absorption von Radarstrahlung, z. B. für Tarnkappenflugzeuge, oder kratzfeste Lacke sein.Bei diesen Experimenten wurde beobachtet, daß sich u. U. in der Miniemulsion große Tröpfchen bilden. Ihr Ursprung wird mit einer neuen Modellvorstellung erklärt, die die Einflüsse auf die Stabilität von Miniemulsionen beschreibt.
The past decades are characterized by various efforts to provide complete sequence information of genomes regarding various organisms. The availability of full genome data triggered the development of multiplex high-throughput assays allowing simultaneous measurement of transcripts, proteins and metabolites. With genome information and profiling technologies now in hand a highly parallel experimental biology is offering opportunities to explore and discover novel principles governing biological systems. Understanding biological complexity through modelling cellular systems represents the driving force which today allows shifting from a component-centric focus to integrative and systems level investigations. The emerging field of systems biology integrates discovery and hypothesis-driven science to provide comprehensive knowledge via computational models of biological systems. Within the context of evolving systems biology, investigations were made in large-scale computational analyses on transcript co-response data through selected prokaryotic and plant model organisms. CSB.DB - a comprehensive systems-biology database - (http://csbdb.mpimp-golm.mpg.de/) was initiated to provide public and open access to the results of biostatistical analyses in conjunction with additional biological knowledge. The database tool CSB.DB enables potential users to infer hypothesis about functional interrelation of genes of interest and may serve as future basis for more sophisticated means of elucidating gene function. The co-response concept and the CSB.DB database tool were successfully applied to predict operons in Escherichia coli by using the chromosomal distance and transcriptional co-responses. Moreover, examples were shown which indicate that transcriptional co-response analysis allows identification of differential promoter activities under different experimental conditions. The co-response concept was successfully transferred to complex organisms with the focus on the eukaryotic plant model organism Arabidopsis thaliana. The investigations made enabled the discovery of novel genes regarding particular physiological processes and beyond, allowed annotation of gene functions which cannot be accessed by sequence homology. GMD - the Golm Metabolome Database - was initiated and implemented in CSB.DB to integrated metabolite information and metabolite profiles. This novel module will allow addressing complex biological questions towards transcriptional interrelation and extent the recent systems level quest towards phenotyping.
Die Fusion von Membranen ist ein entscheidender Prozeß bei der Entwicklung von Zellen im Körper. Beispielsweise ist sie eine der Voraussetzungen bei der Befruchtung einer Eizelle durch ein Spermium oder für das Eindringen von Viren in eine Zelle. Membranfusion ist auch notwendig für den Stofftransport in die Zelle hinein oder aus ihr heraus. Die Membranfusion ist daher auch von praktischen Interesse auf den Gebieten der Pharmazeutik und des 'Bioengineering'. Oft muss eine Membran mit der infiziertin Zelle fusionieren, um ein Medikament an sein Zeil zu bringen. Deshalb ist ein Verständnis der Membranfusion von großem Interesse für die Entwicklung von gezielten und effizienten Methoden des 'drug delivery'. Dasselbe gilt für die gezielte Zufuhr von Genen bei der Gentherapie. Obwohl die Membranfusion schon vor nahezu 200 Jahren von dem deutschen Biologen und Mediziner Johannes Müller beobachtet wurde, liegt ein vollständiges Verständnis des Fusionsprozesses von Zellen und (Modell-) Membranen auch heute noch in weiter Ferne. Allerdings hat im letzten Jahrzehnt das Interesse für dieses Forschungsgebiet stark zugenommen. Wissenschaftler der unterschiedlichsten Disziplinen arbeiten daran, die Mechanismen der Membranfusion aufzudecken. Biologen untersuchen Proteine, die die Fusion auslösen, Chemiker entwickeln Moleküle, die die Fusion erleichtern, und Physiker versuchen die Antriebsmechanismen der Membranfusion zu verstehen. Neue Mikroskopietechniken und die hohe Rechenleistung moderner Computer helfen die molekulare und die makroskopische Welt der Membranfusion in einem Bild zusammenzufügen. Für unsere Untersuchungen haben wir Modellmembranen, die aus Lipiddoppelschichten bestehen, benutzt. Diese Membranen formen sogenannte Vesikel oder Liposomen, abgeschlossene Membrane, in denen eine bestimmte Menge an Flüssigkeit enthalten ist. Indem wir Rezeptoren in die Membran einbringen, schaffen wir funkionalisierte Vesikel, die sich differenzieren, kooperieren und selektiv reagieren können. Wir benutzen positiv geladene wasserlösliche Ionen, um Wechselwirkungen zwischen den Vesikeln zu vermitteln, und lassen die Rezeptoren und die Ionen den Fusionsprozess auslösen. Die Wechselwirkungen werden unter dem Mikroskop durch spezielle Mikromechanischn Gerätz Mikromechinerien kontrolliert. Mit Hilfe einer sehr schnellen digitale Bildaufnahmetechnik ist es uns gelungen, die Fusion unserer Modellmembranen aufzunehmen und in Echtzeit zu dokumentieren mit einer Auflösung von 50 µs. Unsere Messungen können vergleichen werden mit Computersimulationen des Fusionsprozesses. Diese Simulationen untersuchen Prozesse, die zwischen 0.1 und 1 Mikrosekunde dauern. Eine Herausforderung für die Zukunft wird es sein, die Lücke zwischen den in Experimenten (50µs) und den in Simulationen zugänglichen Zeitskalen von beiden Seiten her zu schließen.
Adverb positioning is guided by syntactic, semantic, and pragmatic considerations and is subject to cross-linguistic as well as language-specific variation. The goal of the thesis is to identify the factors that determine adverb placement in general (Part I) as well as in constructions in which the adverb's sister constituent is deprived of its phonetic material by movement or ellipsis (gap constructions, Part II) and to provide an Optimality Theoretic approach to the contrasts in the effects of these factors on the distribution of adverbs in English, French, and German. In Optimality Theory (Prince & Smolensky 1993), grammaticality is defined as optimal satisfaction of a hierarchy of violable constraints: for a given input, a set of output candidates are produced out of which that candidate is selected as grammatical output which optimally satisfies the constraint hierarchy. Since grammaticality crucially relies on the hierarchic relations of the constraints, cross-linguistic variation can be traced back to differences in the language-specific constraint rankings. Part I shows how diverse phenomena of adverb placement can be captured by corresponding constraints and their relative rankings: - contrasts in the linearization of adverbs and verbs/auxiliaries in English and French - verb placement in German and the filling of the prefield position - placement of focus-sensitive adverbs - fronting of topical arguments and adverbs Part II extends the analysis to a particular phenomenon of adverb positioning: the avoidance of adverb attachment to a phonetically empty constituent (gap). English and French are similar in that the acceptability of pre-gap adverb placement depends on the type of adverb, its scope, and the syntactic construction (English: wh-movement vs. topicalization / VP Fronting / VP Ellipsis, inverted vs. non-inverted clauses; French: CLLD vs. Cleft, simple vs. periphrastic tense). Yet, the two languages differ in which strategies a specific type of adverb may pursue to escape placement in front of a certain type of gap. In contrast to English and French, placement of an adverb in front of a gap never gives rise to ungrammaticality in German. Rather, word ordering has to obey the syntactic, semantic, and pragmatic principles discussed in Part I; whether or not it results in adverb attachment to a phonetically empty constituent seems to be irrelevant: though constraints are active in every language, the emergence of a visible effect of their requirements in a given language depends on their relative ranking. The complex interaction of the diverse factors as well as their divergent effects on adverb placement in the various languages are accounted for by the universal constraints and their language-specific hierarchic relations in the OT framework.
Fault planes of large earthquakes incorporate inhomogeneous structures. This can be observed in teleseismic studies through the spatial distribution of slip and seismic moment release caused by the mainshock. Both parameters are often concentrated on patches on the fault plane with much higher values for slip and moment release than their adjacent areas. These patches are called asperities which obviously have a strong influence on the mainshock rupture propagation. Condition and properties of structures in the fault plane area, which are responsible for the evolution of such asperities or their significance on damage distributions of future earthquakes, are still not well understood and subject to recent geo-scientific studies. In the presented thesis asperity structures are identified on the fault plane of the Mw=8.0 Antofagasta earthquake in northern Chile which occurred on 30th of July, 1995. It was a thrust-type event in the seismogenic zone between the subducting pacific Nazca plate and the overriding South American plate. In cooperation of the German Task Force for Earthquakes and the CINCA'95 project a network of up to 44 seismic stations was set up to record the aftershock sequence. The seaward extension of the network with 9 OBH stations increased significantly the precision of hypocenter determinations. They were distributed mainly on the fault plane itself around the city of Antofagasta and Mejillones Peninsula. The asperity structures were recognized here by the spatial variations of local seismological parameters; at first by the spatial distribution of the seismic b-value on the fault plane, derived from the magnitude-frequency relation of Gutenberg-Richter. The correlation of this b-value map with other parameters like the mainshock source time function, the gravity isostatic residual anomalies, the aftershock radiated seismic energy distribution and the vp/vs ratios from a local earthquake tomograhpy study revealed some ideas about the composition and asperity generating processes. The investigation of 295 aftershock focal mechanism solutions supported the resulting fault plane structure and proposed a 3D similar stress state in the area of the Antofagasta fault plane.
Environmental stresses such as drought, high salt and low temperature affect plant growth and decrease crop productivity extremely. It is important to improve stress tolerance of the crop plant to increase crop yield under stress conditions. The Arabidopsis thaliana salt tolerance 1 gene (AtSTO1) was originally identified by Lippuner et al., (1996). In this study around 27 members of STO-like proteins were identified in Arabidopsis thaliana, rice and other plant species. The STO proteins have two consensus motifs (CCADEAAL and FCV(L)EDRA). The STO family members can be regarded as a distinct class of C2C2 proteins considering their low sequence similarity to other GATA like proteins and poor conservation in the C-terminus. AtSTO1 was found to be induced by salt, cold and drought in leaves and roots of 4-week-old Arabidopsis thaliana wild-type plants. The expression of AtSTO1 under salt and cold stress was more pronounced in roots than in leaves. The data provided here revealed that the AtSTO1 protein is localized in the nucleus. The observation that AtSTO1 localizes in the nucleus is consistent with its proposed function as a transcription factor. AtSTO1-dependent phenotypes were observed when plant were grown at 50 mM NaCl on agar plates. Leaves of AtSTO1 overexpression lines were bigger with dark green coloration, whereas stunted growth and yellowish leaves were observed in wild-type and RNAi plants. Also, the AtSTO1 overexpression plants when exposed to long-term cold stress had a red leaf coloration which was much stronger than in wild-type and RNAi lines. Growth of AtSTO1 overexpression lines in long term under salt and cold stress was always associated with long roots which was more pronounced than in wild-type and RNAi lines. Proline accumulation increased more strongly in leaves and roots of AtSTO1 overexpression lines than in tissues of wild-type and RNAi lines when treated with 200 mM NaCl, exposed to cold stress or when watering was prevented for one day or two weeks. Also, soluble sugar content increased to higher levels under salt, cold and drought stress in AtSTO1 overexpression lines when compared to wild-type and RNAi lines. The increase in soluble sugar content was detected in AtSTO1 overexpression lines after long-term (2 weeks) growth of plants under these stresses. Anthocyanins accumulated in leaves of AtSTO1 overexpression lines when exposed to long term salt stress (200 mM NaCl for 2 weeks) or to 4°C for 6 and 8 weeks. Also, anthocyanin content was increased in flowers of AtSTO1 overexpression plants kept at 4°C for 8 weeks. Taken together these data indicate that overexpression of AtSTO1 enhances abiotic stress toleranc via a more pronounced accumulation of compatible solutes under stress.
Statistik Lernen im Rahmen des Psychologiestudiums wurde als Untersuchungsgegenstand zur empirischen Überprüfung der angenommenen Wirkung volitionaler Handlungsregulation herangezogen. Neben fähigkeitsbezogenen und motivationalen Faktoren sollten bei dieser von vielen Studierenden aversiv erlebten Tätigkeit die Aspekte der volitionalen Handlungsregulation entscheidend sein. Nur Personen, die sich trotz des aversiven Tätigkeitserlebens zum Statistik Lernen "zwingen" können, sollten erfolgreich sein. Auf dem Hintergrund des Prozessmodells der Lernmotivation wurden die angenommenen Wirkungen der volitionalen Faktoren denen der motivationalen Einflussgrößen zugeordnet und in einem längsschnittlichen Design an zwei aufeinander folgenden Wintersemestern an der Universität Potsdam und an der TU Berlin empirisch überprüft (N = 273). Die Annahmen zu den fähigkeits- und motivationsrelevanten Faktoren des analyseleitenden Prozessmodells der Lernmotivation konnten weitgehend bestätigt werden. Die Personenmerkmale (fähigkeitsbezogene Merkmale, Leistungsmotiv und Commitment für das Psychologiestudium) bedingen zu einem wesentlichen Teil die Aspekte der aktuellen Motivation für das Statistik Lernen. Letztere wurde durch die Komponenten des Erweiterten Kognitiven Motivationsmodells (EKM) und anhand der Lernintentionen erfasst. Dabei zeigt sich, dass die aktuelle Motivation für das Statistik Lernen insgesamt günstig ausgeprägt ist. Die Aspekte der aktuellen Motivation beeinflussen wiederum Prozessvariablen wie den Lernaufwand, das emotionale Erleben und den Funktionszustand während des Lernens. Der Lernaufwand und das Flow-Erleben (als Indikator für den Funktionszustand) sowie deren Interaktion sagen die Klausurleistung am Ende des Semesters vorher (dies auch, wenn fähigkeitsbezogene Merkmale mit berücksichtigt werden). Vor dem Hintergrund des insgesamt theoriekonsistenten Gesamtbildes ergeben sich dennoch einige Abweichungen von den theoretischen Annahmen. Diese werden eingehend diskutiert. Entgegen der zentralen Annahme, tragen die dem Prozessmodell der Lernmotivation zugeordneten volitionalen Faktoren insgesamt betrachtet kaum zu einem weitergehenden Verständnis des Lernprozesses bei. Die theoretischen Annahmen können weitgehend nicht bestätigt werden. So sagen die volitionalen Faktoren nicht, wie angenommen, bei hoher instrumenteller Handlungsveranlassung und gleichzeitig aversivem Tätigkeitserleben Prozessmerkmale des Lernens vorher. Ausführlich diskutiert wird, inwieweit dies auf falsche theoretische Annahmen oder auf eine mangelnde Operationalisierung und Auswertung zurück geht. Zusätzlich zum Prozessmodell der Lernmotivation wurden weitergehende Annahmen zur Wirkung des impliziten und expliziten Leistungsmotivs überprüft. Dabei zeigt sich erwartungsgemäß, dass sich das implizite Leistungsmotiv beim Statistik Lernen bei einer individuellen Bezugsnorm förderlich auswirkt. Die moderierende Wirkung der sozialen Bezugsnorm für das explizite Leistungsmotiv kann anhand der vorliegenden Daten nicht bestätigt werden. Für das implizite Leistungsmotiv zeigt sich über die Annahmen hinaus eine förderliche Wirkung auf die Klausurteilnahme. Für Personen mit einem hohen impliziten Leistungsmotiv findet sich eine höhere Wahrscheinlichkeit, die Klausur mitzuschreiben. Dieser Befund macht den in der Leistungsmotivationsforschung gefundenen Zusammenhang zwischen Leistungsmotiv und Karriereerfolg "im Kleinen" verständlich. Theoretische Arbeiten legen nahe, dass die volitionale Handlungssteuerung nicht eine unabhängige, sondern eine zum Teil von dem Zusammenwirken der impliziten und expliziten Motivsysteme abhängige Größe darstellt. Für das Leistungsmotiv konnte dies bestätigt werden. So wirkt sich eine hohe Ausprägung des expliziten Leistungsmotivs dann positiv auf die volitionale Handlungssteuerung aus, wenn das implizite Leistungsmotiv hoch ausgeprägt ist. Die Ergebnisse bei den Machtmotivsystemen zeigen, dass nicht immer eine Übereinstimmung der Motive förderlich ist. Eine funktionale Perspektive scheint hier angemessen und weiterführend. Die Arbeit schließt mit der Frage, welche Motivkonstellationen im Sinne einer volitionalen Handlungssteuerung ideal sind. Dabei wird postuliert, dass das Wissen über implizite Vorlieben einer Person helfen sollte, für sie passende Situationen aktiv aufzusuchen oder herzustellen und dadurch eine volitionale Handlungssteuerung besser gelingt sowie diese Art der Steuerung weniger nötig macht.
New chain transfer agents based on dithiobenzoate and trithiocarbonate for free radical polymerization via Reversible Addition-Fragmentation chain Transfer (RAFT) were synthesized. The new compounds bear permanently hydrophilic sulfonate moieties which provide solubility in water independent of the pH. One of them bears a fluorophore, enabling unsymmetrical double end group labelling as well as the preparation of fluorescent labeled polymers. Their stability against hydrolysis in water was studied, and compared with the most frequently employed water-soluble RAFT agent 4-cyano-4-thiobenzoylsulfanylpentanoic acid dithiobenzoate, using UV-Vis and 1H-NMR spectroscopy. An improved resistance to hydrolysis was found for the new RAFT agents, providing good stabilities in the pH range between 1 and 8, and up to temperatures of 70°C. Subsequently, a series of non-ionic, anionic and cationic water-soluble monomers were polymerized via RAFT in water. In these experiments, polymerizations were conducted either at 48°C or 55°C, that are lower than the conventionally employed temperatures (>60°C) for RAFT in organic solvents, in order to minimize hydrolysis of the active chain ends (e.g. dithioester and trithiocarbonate), and thus to obtain good control over the polymerization. Under these conditions, controlled polymerization in aqueous solution was possible with styrenic, acrylic and methacrylic monomers: molar masses increase with conversion, polydispersities are low, and the degree of end group functionalization is high. But polymerizations of methacrylamides were slow at temperatures below 60°C, and showed only moderate control. The RAFT process in water was also proved to be a powerful method to synthesize di- and triblock copolymers including the preparation of functional polymers with complex structure, such as amphiphilic and stimuli-sensitive block copolymers. These include polymers containing one or even two stimuli-sensitive hydrophilic blocks. The hydrophilic character of a single or of several blocks was switched by changing the pH, the temperature or the salt content, to demonstrate the variability of the molecular designs suited for stimuli-sensitive polymeric amphiphiles, and to exemplify the concept of multiple-sensitive systems. Furthermore, stable colloidal block ionomer complexes were prepared by mixing anionic surfactants in aqueous media with a double hydrophilic block copolymer synthesized via RAFT in water. The block copolymer is composed of a noncharged hydrophilic block based on polyethyleneglycol and a cationic block. The complexes prepared with perfluoro decanoate were found so stable that they even withstand dialysis; notably they do not denaturate proteins. So, they are potentially useful for biomedical applications in vivo.
Taking inspiration from nature, where composite materials made of a polymer matrix and inorganic fillers are often found, e.g. bone, shell of crustaceans, shell of eggs, etc., the feasibility on making composite materials containing chitosan and nanosized hydroxyapatite were investigated. A new preparation approach based on a co-precipitation method has been developed. In its earlier stage of formation, the composite occurs as hydrogel as suspended in aqueous alkaline solution. In order to get solid composites various drying procedures including freeze-drying technique, air-drying at room temperature and at moderate temperatures, between 50oC and 100oC were used. Physicochemical studies showed that the composites exhibit different properties with respect to their structure and composition. IR and Raman spectroscopy probed the presence of both chitosan and hydroxyapatite in the composites. Hydroxyapatite as dispersed in the chitosan matrix was found to be in the nanosize range (15-50 nm) and occurs in a bimodal distribution with respect to its crystallite length. Two types of distribution domains of hydroxyapatite crystallites in the composite matrix such as cluster-like (200-400 nm) and scattered-like domains were identified by the transmission electron microscopy (TEM), X-ray diffraction (XRD) and by confocal scanning laser microscopy (CSLM) measurements. Relaxation NMR experiments on composite hydrogels showed the presence of two types of water sites in their gel networks, such as free and bound water. Mechanical tests showed that the mechanical properties of composites are one order of magnitude less than those of compact bone but comparable to those of porous bone. The enzymatic degradation rates of composites showed slow degradation processes. The yields of degradation were estimated to be less than 10% by loss of mass, after incubation with lysozyme, for a period of 50 days. Since the composite materials were found biocompatible by the in vivo tests, the simple mode of their fabrication and their properties recommend them as potential candidates for the non-load bearing bone substitute materials.
Zur Beherrschung großer Systeme, insbesondere zur Weitergabe und Nutzung von Erfahrungswissen in der frühen Entwurfs- und Planungsphase, benötigt man Abstraktionen für deren Strukturen. Trennt man Software- von Systemstrukturen, kann man mit letzteren Systeme auf ausreichend hohem Abstraktionsgrad beschreiben.Software-Patterns dienen dazu, Erfahrungswissen bezüglich programmierter Systeme strukturiert weiterzugeben. Dabei wird unterschieden zwischen Idiomen, die sich auf Lösungen mit einer bestimmten Programmiersprache beziehen, Design-Patterns, die nur einen kleinen Teil des Programms betreffen und Architektur-Patterns, deren Einfluss über einen größeren Teil oder gar das komplette Programm reicht. Eine Untersuchung von existierenden Patterns zeigt, dass deren Konzepte nützlich zum Finden von Systemstrukturen sind. Die grafische Darstellung dieser Patterns ist dagegen oft auf Software-Strukturen eingeschränkt und ist für die Vermittlung von Erfahrungen zum Finden von Systemstrukturen meist nicht geeignet. Daher wird die Kategorie der konzeptionellen Patterns mit einer darauf abgestimmten grafischen Darstellungsform vorgeschlagen, bei denen Problem und Lösungsvorschlag im Bereich der Systemstrukturen liegen. Sie betreffen informationelle Systeme, sind aber nicht auf Lösungen mit Software beschränkt. Die Systemstrukturen werden grafisch dargestellt, wobei dafür die Fundamental Modeling Concepts (FMC) verwendet werden, die zur Darstellung von Systemstrukturen entwickelt wurden.