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As part of the International Continental Drilling Program deep lake drilling project Paleo Van, we investigated sulfate reduction (SR) in deep sediment cores of the saline, alkaline (salinity 21.4%0, alkalinity 155 m mEq-1, pH 9.81) Lake Van, Turkey. The cores were retrieved in the Northern Basin (NB) and at Ahlat Ridge (AR) and reached a maximum depth of 220 m. Additionally, 65-75 cm long gravity cores were taken at both sites. SR rates (SRR) were low (<22 nmol cm-3 day-1) compared to lakes with higher salinity and alkalinity, indicating that salinity and alkalinity are not limiting SR in Lake Van. Both sites differ significantly in rates and depth distribution of SR. In NB, SRR are up to 10 times higher than at AR. SR could be detected down to 19 mblf (meters below lake floor) at NB and down to 13 mblf at AR. Although SRR were lower at AR than at NB, organic matter (OM) concentrations were higher. In contrast, dissolved OM in the pore water at AR contained more macromolecular OM and less low molecular weight OM.VVe thus suggest, that OM content alone cannot be used to infer microbial activity at Lake Van but that quality of OM has an important impact as well. These differences suggest that biogeochemical processes in lacustrine sediments are reacting very sensitively to small variations in geological, physical, or chemical parameters over relatively short distances.
Ether functionalities form an important cross-linking structure within the macromolecular organic matrix of lignites and coals. To obtain a deeper insight into the complex internal structure of such macromolecules and the maturation related changes of the ether compounds within the network structure, boron tribromide (BBr3) ether cleavage was applied to a series of lignite and coal samples of different maturity (R-0 0.27-0.80%) obtained from coal mines and natural outcrops from the North and South Island of New Zealand. Terminal ether-bound alcohols rapidly decrease during diagenesis and occur only in low amounts during the catagenetic stage. Comparison between ester- and ether-bound terminal alcohols indicates a parallel decreasing trend during the diagenetic stage, suggesting that the stability differences between both linkages are not large enough to be observed in maturation processes over geological time scales:Polyether compounds were detected with chain length up to five carbon atoms. After a small decrease during the diagenetic phase these compounds occur in relatively high concentrations, even in the main catagenetic stage. This suggests that these linkage structures represent important cross-linking substructures within the macromolecular matrix of lignites and coals being sterically protected within the macromolecular network during the maturation process. Additional cross-linking substructures were (poly)ether aromatics, esters and ketones.
Gutachten zur Entstehung und Entwicklung von Management-Buy-Out Unternehmen im Land Brandenburg
(1992)
Die Entwicklung der privaten Haushalte unter den Bedingungen der Transformation in Ostdeutschland
(1995)
Die Entwicklung der privaten Haushalte unter den Bedingungen der Transformation in Ostdeutschland
(1995)
Molecular mechanisms controlling plant totipotency are largely unknown and studies on somatic embryogenesis (SE), the process through which already differentiated cells reverse their developmental program and become embryogenic, provide a unique means for deciphering molecular mechanisms controlling developmental plasticity of somatic cells. Among various factors essential for embryogenic transition of somatic cells transcription factors (TFs), crucial regulators of genetic programs, are believed to play a central role. Herein, we used quantitative real-time polymerase chain reaction (qRT-PCR) to identify TF genes affected during SE induced by in vitro culture in Arabidopsis thaliana. Expression profiles of 1,880 TFs were evaluated in the highly embryogenic Col-0 accession and the non-embryogenic tanmei/emb2757 mutant. Our study revealed 729 TFs whose expression changes during the 10-days incubation period of SE; 141 TFs displayed distinct differences in expression patterns in embryogenic versus non-embryogenic cultures. The embryo-induction stage of SE occurring during the first 5 days of culture was associated with a robust and dramatic change of the TF transcriptome characterized by the drastic up-regulation of the expression of a great majority (over 80%) of the TFs active during embryogenic culture. In contrast to SE induction, the advanced stage of embryo formation showed attenuation and stabilization of transcript levels of many TFs. In total, 519 of the SE-modulated TFs were functionally annotated and transcripts related with plant development, phytohormones and stress responses were found to be most abundant. The involvement of selected TFs in SE was verified using T-DNA insertion lines and a significantly reduced embryogenic response was found for the majority of them. This study provides comprehensive data focused on the expression of TF genes during SE and suggests directions for further research on functional genomics of SE.
E-Learning
(2015)
Research on corporate entrepreneurship—venturing activities by established corporations—has received increasing scholarly attention. We employ bibliometric methods to analyze the literature on corporate entrepreneurship published over the last five decades. Based on the results of citation and co-citation analyses, we reveal central works in the field and how they are interconnected. We investigate the underlying intellectual structure of the field. Our findings provide evidence of the growing maturity and interdisciplinarity of corporate entrepreneurship and provide insight into research themes. We find that resource-based view and its extensions still remain the predominant theoretical perspectives in the field. Drawing on these findings, we suggest directions for future research.
Research on corporate entrepreneurship—venturing activities by established corporations—has received increasing scholarly attention. We employ bibliometric methods to analyze the literature on corporate entrepreneurship published over the last five decades. Based on the results of citation and co-citation analyses, we reveal central works in the field and how they are interconnected. We investigate the underlying intellectual structure of the field. Our findings provide evidence of the growing maturity and interdisciplinarity of corporate entrepreneurship and provide insight into research themes. We find that resource-based view and its extensions still remain the predominant theoretical perspectives in the field. Drawing on these findings, we suggest directions for future research.
The influence of the charge density of polyelectrolytes on the growth of polyelectrolyte multilayers via layer- by-layer self-assembly from pure aqueous solutions was studied. Multilayers were built from strong polyanions, namely poly(styrenesulfonate) and an exfoliated synthetic hectorite, and cationic copolymers of diallyldimethylammonium chloride (DADMAC) with N-methyl-N-vinylformamide (NMVF) for which the composition and thus the charge density was varied systematically. The analysis of the system {cationic copolymer/poly(styrenesulfonate)} reveals that a critical linear charge density Ïc of 0.036 elementary charge/Å of contour length is necessary to obtain stable multilayer growth in pure water. Above Ïc, the increment of thickness/deposition cycle varies with the linear charge density of the cationic copolymers, in good agreement with current theories of polyelectrolyte solutions. As linear charge density increases, the system passes successively through a charge-dependent ?Debye-Hu ckel? regime and then through a chargeindependent ?strong-screening? regime where counterion condensation dominates the behavior. Analogous results were obtained for the variation of the basal spacing of internally structured hybrid multilayers {cationic copolymer/hectorite}. However, by contrast with the first system, no critical linear charge density was found for the hybrid system. This is explained by additional, nonelectrostatic interactions between the clay platelets and the formamide fragment.
We report on the growth and structure of hybrid clay-based multilayers obtained by electrostatic self-assembly (also known as layer-by-layer assembly) of poly(diallylpyrrolidinium bromide) and a synthetic hectorite (Laponite). By combining ellipsometry, atomic force microscopy, and specular and off-specular grazing angle X-ray scattering measurements, we show that platelets pack in the vertical direction according to a distribution of distances between nearest neighbors of about 3 Å standard deviation. The accumulation of such random fluctuations in the vertical direction results in the loss of layering of the platelets farther than about 75 Å from the substrate. In this respect, most of the film should be considered as a nanocomposite with preferential orientation of the platelets, rather than as a real multilayer. The model is quantitatively supported by simulations of the specular and off-specular scattering of such multilayers.
Parataxe et subordination, ces deux termes, parfois antithétiques, sont problématiques du fait même de leur extrême polysémie. C’est de cette ambiguïté que naît l’objet d’étude, les constructions asyndétiques, au statut incertain entre intégration et indépendance. Dans cette thèse, nous proposons de réinterroger ce phénomène ancien et déjà bien connu en ancien français, en le mettant en regard des remises en question et avancées des recherches actuelles sur le sujet. Pour cela, il nous faut tout d'abord poser une définition de ce qu'est la subordination. Nous montrons ensuite que les constructions asyndétiques sont bien des cas de subordination. Cette thèse établit enfin que ce phénomène constitue, en ancien français du moins, une variante libre en syntaxe. Sa répartition et sa présence dans les textes a cependant très tôt diminué, mais l’existence de phénomènes parallèles en français moderne, tout comme d’autres indices, nous permettent de faire l’hypothèse que cette évolution tient d’une alternance oral / écrit. Cette thèse montre ainsi que les problèmes, comme les enjeux, ne diffèrent finalement pas, quel que soit l’état de langue et que la parataxe constitue bien une construction dans le système de la langue.
Decreasing groundwater levels in many parts of Germany and decreasing low flows in Central Europe have created a need for adaptation measures to stabilize the water balance and to increase low flows. The objective of our study was to estimate the impact of ditch water level management on stream-aquifer interactions in small lowland catchments of the mid-latitudes. The water balance of a ditch-irrigated area and fluxes between the subsurface and the adjacent stream were modeled for three runoff recession periods using the Hydrus-2D software package. The results showed that the subsurface flow to the stream was closely related to the difference between the water level in the ditch system and the stream. Evapotranspiration during the growing season additionally reduced base flow. It was crucial to stop irrigation during a recession period to decrease water withdrawal from the stream and enhance the base flow by draining the irrigated area. Mean fluxes to the stream were between 0.04 and 0.64 ls(-1) for the first 20 days of the low-flow periods. This only slightly increased the flow in the stream, whose mean was 57 ls(-1) during the period with the lowest flows. Larger areas would be necessary to effectively increase flows in mesoscale catchments.
Decreasing groundwater levels in many parts of Germany and decreasing low flows in Central Europe have created a need for adaptation measures to stabilize the water balance and to increase low flows. The objective of our study was to estimate the impact of ditch water level management on stream-aquifer interactions in small lowland catchments of the mid-latitudes. The water balance of a ditch-irrigated area and fluxes between the subsurface and the adjacent stream were modeled for three runoff recession periods using the Hydrus-2D software package. The results showed that the subsurface flow to the stream was closely related to the difference between the water level in the ditch system and the stream. Evapotranspiration during the growing season additionally reduced base flow. It was crucial to stop irrigation during a recession period to decrease water withdrawal from the stream and enhance the base flow by draining the irrigated area. Mean fluxes to the stream were between 0.04 and 0.64 ls(-1) for the first 20 days of the low-flow periods. This only slightly increased the flow in the stream, whose mean was 57 ls(-1) during the period with the lowest flows. Larger areas would be necessary to effectively increase flows in mesoscale catchments.
The Victoria microplate between the Eastern and Western Branches of the East African Rift System is one of the largest continental microplates on Earth. In striking contrast to its neighboring plates, Victoria rotates counterclockwise with respect to Nubia. The underlying cause of this distinctive rotation has remained elusive so far. Using 3D numerical models, we investigate the role of pre-existing lithospheric heterogeneities in continental microplate rotation. We find that Victoria's rotation is primarily controlled by the distribution of rheologically stronger zones that transmit the drag of the major plates to the microplate and of the mechanically weaker mobile belts surrounding Victoria that facilitate rotation. Our models reproduce Victoria's GPS-derived counterclockwise rotation as well as key complexities of the regional tectonic stress field. These results reconcile competing ideas on the opening of the rift system by highlighting differences in orientation of the far-field divergence, local extension, and the minimum horizontal stress. One of the largest continental microplates on Earth is situated in the center of the East African Rift System, and oddly, the Victoria microplate rotates counterclockwise with respect to the neighboring African tectonic plate. Here, the authors' modelling results suggest that Victoria microplate rotation is caused by edge-driven lithospheric processes related to the specific geometry of rheologically weak and strong regions.
Aim Hospitals noticeably struggle with maintaining hundreds of IT systems and applications in compliance with the latest IT standards and regulations. Thus, hospitals search for efficient opportunities to discover and integrate useful digital health innovations into their existing IT landscapes. In addition, although a multitude of digital innovations from digital health startups enter the market, numerous barriers impede their successful implementation and adoption. Against this background, the aim of this study was to explore typical digital innovation barriers in hospitals, and to assess how a hospital data management platform (HDMP) architecture might help hospitals to extract such innovative capabilities. Subject and methods Based on the concept of organizational ambidexterity (OA), we pursued a qualitative mixed-methods approach. First, we explored and consolidated innovation barriers through a systematic literature review, interviews with 20 startup representatives, and a focus group interview with a hospital IT team and the CEO of an HDMP provider. Finally, we conducted a case-study analysis of 36 digital health startups to explore and conceptualize the potential impact of DI and apply the morphological method to synthesize our findings from a multi-level perspective. Results We first provide a systematic and conceptual overview of typical barriers for digital innovation in hospitals. Hereupon, we explain how an HDMP might enable hospitals to mitigate such barriers and extract value from digital innovations at both individual and organizational level. Conclusion Our results imply that an HDMP can help hospitals to approach organizational ambidexterity through integrating and maintaining hundreds of systems and applications, which allows for a structured and controlled integration of external digital innovations.
The educational sector currently faces a massive digital transformation with various digital offerings entering the market. To provide some orientation in this transforming space, a national digital education platform (NDEP) is under development in Germany as part of a nationwide flagship project. On the one hand, in efficiently connecting the relevant stakeholders to each other and to value-adding education-related offerings, various benefits emerge. On the other hand, monopolising the educational sector and influencing the respective market through a state-controlled platform bears potential regulatory risks from misuse of power by the platform to malpractice by the users. Against this background, we aim to identify and systematise these potential drawbacks prior to the platform’s actual development and implementation. We pursue a qualitative, interpretivist approach for policy analysis, based on ten elite interviews and two workshops. Our results are threefold: (1) We capture the consolidated NDEP architecture; (2) We categorise the range of relevant functions and value propositions of the NDEP; (3) We derive 23 regulatory areas of conflict across the three building blocks that result from the potential ecosystem and function scope configurations of the NDEP. As a contribution to research, we shed new interdisciplinary light on the governance and infrastructure of public-private platforms that enable innovation and collaboration while integrating respective market segments. As a contribution to practice, we provide clear guidance for policy-makers in strategizing the development and governance of and through national digital platforms in education.
Digital transformation (DT) has not only been a major challenge in recent years, it is also supposed to continue to enormously impact our society and economy in the forthcoming decade. On the one hand, digital technologies have emerged, diffusing and determining our private and professional lives. On the other hand, digital platforms have leveraged the potentials of digital technologies to provide new business models. These dynamics have a massive effect on individuals, companies, and entire ecosystems. Digital technologies and platforms have changed the way persons consume or interact with each other. Moreover, they offer companies new opportunities to conduct their business in terms of value creation (e.g., business processes), value proposition (e.g., business models), or customer interaction (e.g., communication channels), i.e., the three dimensions of DT. However, they also can become a threat for a company's competitiveness or even survival. Eventually, the emergence, diffusion, and employment of digital technologies and platforms bear the potential to transform entire markets and ecosystems.
Against this background, IS research has explored and theorized the phenomena in the context of DT in the past decade, but not to its full extent. This is not surprising, given the complexity and pervasiveness of DT, which still requires far more research to further understand DT with its interdependencies in its entirety and in greater detail, particularly through the IS perspective at the confluence of technology, economy, and society. Consequently, the IS research discipline has determined and emphasized several relevant research gaps for exploring and understanding DT, including empirical data, theories as well as knowledge of the dynamic and transformative capabilities of digital technologies and platforms for both organizations and entire industries.
Hence, this thesis aims to address these research gaps on the IS research agenda and consists of two streams. The first stream of this thesis includes four papers that investigate the impact of digital technologies on organizations. In particular, these papers study the effects of new technologies on firms (paper II.1) and their innovative capabilities (II.2), the nature and characteristics of data-driven business models (II.3), and current developments in research and practice regarding on-demand healthcare (II.4). Consequently, the papers provide novel insights on the dynamic capabilities of digital technologies along the three dimensions of DT. Furthermore, they offer companies some opportunities to systematically explore, employ, and evaluate digital technologies to modify or redesign their organizations or business models.
The second stream comprises three papers that explore and theorize the impact of digital platforms on traditional companies, markets, and the economy and society at large. At this, paper III.1 examines the implications for the business of traditional insurance companies through the emergence and diffusion of multi-sided platforms, particularly in terms of value creation, value proposition, and customer interaction. Paper III.2 approaches the platform impact more holistically and investigates how the ongoing digital transformation and "platformization" in healthcare lastingly transform value creation in the healthcare market. Paper III.3 moves on from the level of single businesses or markets to the regulatory problems that result from the platform economy for economy and society, and proposes appropriate regulatory approaches for addressing these problems. Hence, these papers bring new insights on the table about the transformative capabilities of digital platforms for incumbent companies in particular and entire ecosystems in general.
Altogether, this thesis contributes to the understanding of the impact of DT on organizations and markets through the conduction of multiple-case study analyses that are systematically reflected with the current state of the art in research. On this empirical basis, the thesis also provides conceptual models, taxonomies, and frameworks that help describing, explaining, or predicting the impact of digital technologies and digital platforms on companies, markets and the economy or society at large from an interdisciplinary viewpoint.
The increasing prevalence and ubiquity of digital technologies is changing the needs and expectations of patients towards healthcare services. As a result, a plethora of patient-centered services edges into the healthcare market. Since digital technologies bear the potential to surmount barriers in time and space, patients increasingly demand real-time or near-time healthcare services. Amongst a cloud of related concepts in the context of digital health, one term increasingly typifies this impulse: on-demand healthcare. While this term can be noticeably found in practice, there is hardly some theoretical foundation so far. Against this background, the aim of this paper is to address this research gap and to explore the phenomenon of on-demand healthcare. Based on a design-science approach including a literature review and analysis of in-depth interviews and empirical cases, the outcome of this paper is twofold: (1) a conceptual framework and (2) a proposal for a definition of on-demand healthcare.
An apple a day
(2021)
The healthcare industry has been slow to adopt new technologies and practices. However, digital and data-enabled innovations diffuse the market, and the COVID-19 pandemic has recently emphasized the necessity of a fundamental digital transformation. Available research indicates the relevance of digital platforms in this process but has not studied their economic impact to date. In view of this research gap and the social and economic relevance of healthcare, we explore how digital platforms might affect value creation in this market with a particular focus on Google, Apple, Facebook, Amazon, and Microsoft (GAFAM). We rely on value network analyses to examine how GAFAM platforms introduce new value-creating roles and mechanisms in healthcare through their manifold products and services. Hereupon, we examine the GAFAM-impact on healthcare by scrutinizing the facilitators, activities, and effects. Our analyses show how GAFAM platforms multifacetedly untie conventional relationships and transform value creation structures in the healthcare market.
Alcohol use disorder (AUD) is the most common substance use disorder worldwide. Although dopamine-related findings were often observed in AUD, associated neurobiological mechanisms are still poorly understood. Therefore, in the present study, we investigate D2/3 receptor availability in healthy participants, participants at high risk (HR) to develop addiction (not diagnosed with AUD), and AUD patients in a detoxified stage, applying F-18-fallypride positron emission tomography (F-18-PET). Specifically, D2/3 receptor availability was investigated in (1) 19 low-risk (LR) controls, (2) 19 HR participants, and (3) 20 AUD patients after alcohol detoxification. Quality and severity of addiction were assessed with clinical questionnaires and (neuro)psychological tests. PET data were corrected for age of participants and smoking status. In the dorsal striatum, we observed significant reductions of D2/3 receptor availability in AUD patients compared with LR participants. Further, receptor availability in HR participants was observed to be intermediate between LR and AUD groups (linearly decreasing). Still, in direct comparison, no group difference was observed between LR and HR groups or between HR and AUD groups. Further, the score of the Alcohol Dependence Scale (ADS) was inversely correlated with D2/3 receptor availability in the combined sample. Thus, in line with a dimensional approach, striatal D2/3 receptor availability showed a linear decrease from LR participants to HR participants to AUD patients, which was paralleled by clinical measures. Our study shows that a core neurobiological feature in AUD seems to be detectable in an early, subclinical state, allowing more individualized alcohol prevention programs in the future.
We study the autoresonant solution of Duffing's equation in the presence of dissipation. This solution is proved to be an attracting set. We evaluate the maximal amplitude of the autoresonant solution and the time of transition from autoresonant growth of the amplitude to the mode of fast oscillations. Analytical results are illustrated by numerical simulations.
We consider a solution of the nonlinear Klein-Gordon equation perturbed by a parametric driver. The frequency of parametric perturbation varies slowly and passes through a resonant value, which leads to a solution change. We obtain a new connection formula for the asymptotic solution before and after the resonance.
We consider a resonantly perturbed system of coupled nonlinear oscillators with small dissipation and outer periodic perturbation. We show that for the large time t similar to s(-2) one component of the system is described for the most part by the inhomogeneous Mathieu equation while the other component represents pulsation of large amplitude. A Hamiltonian system is obtained which describes for the most part the behavior of the envelope in a special case. The analytic results agree with numerical simulations.
We construct a special asymptotic solution for the forced KdV equation. In the frame of the shallow water model this kind of the external driving force is related to the atmospheric disturbance. The perturbation slowly passes through a resonance and it leads to the solution exchange. The detailed asymptotic description of the process is presented.