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Institute
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Einleitung
(2008)
Literaturen des Bürgerkriegs
(2008)
Die Bedeutung der Ressource Wissen für die Unternehmensentwicklung ist heutzutage unumstritten. Um wettbewerbsfähig bleiben zu können, müssen Unternehmen die Erzeugung, Teilung und systematische Nutzung von Wissen fördern. Dabei stehen sowohl die individuelle Wissensbasis (und damit jeder Mitarbeiter) als auch die kollektive Wissensbasis (und damit das ganze Unternehmen) im Vordergrund. Der Faktor Kultur gewinnt in diesem Zusammenhang zunehmend an Bedeutung: Er beeinflusst alle drei Ebenen des Wissensmanagements - Mensch, Organisation und Technologie. Neben den Besonderheiten der Organisationskultur und der Kultur unterschiedlicher Mitarbeitergruppen sind in international agierenden Unternehmen auch die spezifischen Merkmale der jeweiligen Landeskultur zu berücksichtigen. Gemeinsam mit dem Lehrstuhl für Wirtschaftsinformatik und Electronic Government der Universität Potsdam hat acatech im Mai 2008 einen Workshop mit Vertretern aus Wirtschaft, Politik und Wissenschaft zum Umgang mit Wissen im interkulturellen Vergleich veranstaltet. Vor diesem Hintergrund entstand der acatech diskutiert-Band "Umgang mit Wissen im interkulturellen Vergleich - Beiträge aus Forschung und Unternehmenspraxis". Darin enthalten sind Beiträge, die u. a. danach fragen, welche wechselseitigen Beziehungen zwischen Technik und Kultur bestehen, inwieweit Experten- und Wissensnetzwerke als interkulturelles Instrument zum Umgang mit Wissen geeignet sind, wie Unternehmen ihre Mitarbeiter auf Auslandseinsätze und die Begegnung mit fremden Kulturen vorbereiten können und welche Rolle Kommunikation als Methode des Wissenstransfers spielt.
Portal alumni
(2008)
Liebe Leserin, lieber Leser, Castingshows schießen in letzter Zeit wie Pilze aus dem Boden. Ein Mangel an Bewerbern für diese Formate scheint nicht zu bestehen. Reich und berühmt sein wie Leonardo DiCaprio, der angeblich sogar mitten im brasilianischen Regenwald von einem Indianer erkannt wurde das ist das Ziel. Die erhoffte Prominenz ist bei Kandidaten dieser Shows oft Selbstzweck. Aber es gibt natürlich auch noch Menschen, die ihre Bekanntheit ihrer künstlerischen Passion, ihrem politischen Engagement oder ihren sportlichen Leistungen verdanken. Mitunter ist es diesen Menschen sogar eher lästig als angenehm, wenn sie im Rampenlicht stehen. Nach solchen Menschen aus dem Kreise unserer Ehemaligen haben wir gesucht und sind fündig geworden. Ihren Werdegang können Sie in unserem Titelthema nachlesen. Wie Prominenz und Persönlichkeit sich gegenseitig beeinflussen, warum Menschen überhaupt im Licht der Öffentlichkeit stehen wollen und wie man mit den negativen Seiten der eigenen Bekanntheit umgehen kann, erläutert Persönlichkeitspsychologe Prof. Dr. Franz Neyer in einem einführenden Artikel. Unter der Rubrik "alumni insight" lesen Sie beispielsweise, wie man in Russland eine Firma gründet oder vor welchen Herausforderungen ein Deutschlehrer in Usbekistan steht. Falls Sie sich gerade bewerben und noch Tipps zum Verfassen Ihres Lebenslaufs suchen, könnte ein Blick in die Rubrik "wegweiser" hilfreich sein.
Während über Max Webers Religionssoziologie ganze Bibliotheken geschrieben worden sind, gibt es zu seiner Rechtssoziologie – ungeachtet ihrer von Talcott Parsons herausgestellten Zentralität in Webers Werk – vergleichsweise wenige Veröffentlichungen. Insbesondere ist sein Verhältnis zur juristischen Methodenlehre nahezu unberücksichtigt geblieben, obwohl er als promovierter und habilitierter Jurist im weitesten Sinne von ihr ausgegangen ist. Max Webers Rechtssoziologie ist für die Rechtsdogmatik nicht zuletzt deshalb so interessant, weil Weber das Recht und die juristische Methode inwendig kannte und von daher deutend verstehen konnte.
Für die Neuauflage hat Jens Petersen alle Nachweise auf die Max-Weber-Gesamtausgabe umgestellt und nicht nur die in den vergangenen fünf Jahren erschienene Literatur zu seiner Rechtssoziologie berücksichtigt, sondern auch älteres Schrifttum.
Background
Epidemiological data indicate elevated psychosocial health risks for physicians, e.g., burnout, depression, marital disturbances, alcohol and substance abuse, and suicide. The purpose of this study was to identify psychosocial health resources and risk factors in profession-related behaviour and experience patterns of medical students and physicians that may serve as a basis for appropriate health promoting interventions.
Methods
The questionnaire -Related Behaviour and Experience "Work administered in cross-sectional surveys to students in the first (n = 475) and in the fifth year of studies (n = 355) in required courses at three German universities and to physicians in early professional life in the vicinity of these universities (n = 381).
Results
Scores reflecting a healthy behaviour pattern were less likely in physicians (16.7%) compared to 5th year (26.0%) and 1st year students (35.1%) while scores representing unambitious and resigned patterns were more common among physicians (43.4% vs. 24.4% vs. 41.0% and 27.3% vs. 17.2% vs. 23.3 respectively). Female and male responders differed in the domains professional commitment, resistance to stress and emotional well-being. Female physicians on average scored higher in the dimensions resignation tendencies, satisfaction with life and experience of social support, and lower in career ambition.
Conclusion
The results show distinct psychosocial stress patterns among medical students and physicians. Health promotion and prevention of psychosocial symptoms and impairments should be integrated as a required part of the medical curriculum and be considered an important issue during the further training of physicians.
Inositol phosphates (IPs) and their turnover products have been implicated to play important roles in stress signaling in eukaryotic cells. In higher plants genes encoding inositol polyphosphate kinases have been identified previously, but their physiological functions have not been fully resolved. Here we expressed Arabidopsis inositol polyphosphate 6-/3-kinase (AtIpk2 beta) in two heterologous systems, i.e. the yeast Saccharomyces cerevisiae and in tobacco (Nicotiana tabacum), and tested the effect on abiotic stress tolerance. Expression of AtIpk2 beta rescued the salt-, osmotic- and temperature-sensitive growth defects of a yeast mutant strain (arg82 Delta) that lacks inositol polyphosphate multikinase activity encoded by the ARG82/IPK2 gene. Transgenic tobacco plants constitutively expressing AtIpk2 beta under the control of the Cauliflower Mosaic Virus 35S promoter were generated and found to exhibit improved tolerance to diverse abiotic stresses when compared to wild type plants. Expression patterns of various stress responsive genes were enhanced, and the activities of anti-oxidative enzymes were elevated in transgenic plants, suggesting a possible involvement of AtIpk2 beta in plant stress responses.
We propose a network structure-based model for heterosis, and investigate it relying on metabolite profiles from Arabidopsis. A simple feed-forward two-layer network model (the Steinbuch matrix) is used in our conceptual approach. It allows for directly relating structural network properties with biological function. Interpreting heterosis as increased adaptability, our model predicts that the biological networks involved show increasing connectivity of regulatory interactions. A detailed analysis of metabolite profile data reveals that the increasing-connectivity prediction is true for graphical Gaussian models in our data from early development. This mirrors properties of observed heterotic Arabidopsis phenotypes. Furthermore, the model predicts a limit for increasing hybrid vigor with increasing heterozygosity—a known phenomenon in the literature.
QuantPrime
(2008)
Background
Medium- to large-scale expression profiling using quantitative polymerase chain reaction (qPCR) assays are becoming increasingly important in genomics research. A major bottleneck in experiment preparation is the design of specific primer pairs, where researchers have to make several informed choices, often outside their area of expertise. Using currently available primer design tools, several interactive decisions have to be made, resulting in lengthy design processes with varying qualities of the assays.
Results
Here we present QuantPrime, an intuitive and user-friendly, fully automated tool for primer pair design in small- to large-scale qPCR analyses. QuantPrime can be used online through the internet http://www.quantprime.de/ or on a local computer after download; it offers design and specificity checking with highly customizable parameters and is ready to use with many publicly available transcriptomes of important higher eukaryotic model organisms and plant crops (currently 295 species in total), while benefiting from exon-intron border and alternative splice variant information in available genome annotations. Experimental results with the model plant Arabidopsis thaliana, the crop Hordeum vulgare and the model green alga Chlamydomonas reinhardtii show success rates of designed primer pairs exceeding 96%.
Conclusion
QuantPrime constitutes a flexible, fully automated web application for reliable primer design for use in larger qPCR experiments, as proven by experimental data. The flexible framework is also open for simple use in other quantification applications, such as hydrolyzation probe design for qPCR and oligonucleotide probe design for quantitative in situ hybridization. Future suggestions made by users can be easily implemented, thus allowing QuantPrime to be developed into a broad-range platform for the design of RNA expression assays.
Thermal radiation processes
(2008)
We discuss the different physical processes that are important to understand the thermal X-ray emission and absorption spectra of the diffuse gas in clusters of galaxies and the warm-hot intergalactic medium. The ionisation balance, line and continuum emission and absorption properties are reviewed and several practical examples are given that illustrate the most important diagnostic features in the X-ray spectra.
Using ESTs for phylogenomics
(2008)
Background
While full genome sequences are still only available for a handful of taxa, large collections of partial gene sequences are available for many more. The alignment of partial gene sequences results in a multiple sequence alignment containing large gaps that are arranged in a staggered pattern. The consequences of this pattern of missing data on the accuracy of phylogenetic analysis are not well understood. We conducted a simulation study to determine the accuracy of phylogenetic trees obtained from gappy alignments using three commonly used phylogenetic reconstruction methods (Neighbor Joining, Maximum Parsimony, and Maximum Likelihood) and studied ways to improve the accuracy of trees obtained from such datasets.
Results
We found that the pattern of gappiness in multiple sequence alignments derived from partial gene sequences substantially compromised phylogenetic accuracy even in the absence of alignment error. The decline in accuracy was beyond what would be expected based on the amount of missing data. The decline was particularly dramatic for Neighbor Joining and Maximum Parsimony, where the majority of gappy alignments contained 25% to 40% incorrect quartets. To improve the accuracy of the trees obtained from a gappy multiple sequence alignment, we examined two approaches. In the first approach, alignment masking, potentially problematic columns and input sequences are excluded from from the dataset. Even in the absence of alignment error, masking improved phylogenetic accuracy up to 100-fold. However, masking retained, on average, only 83% of the input sequences. In the second approach, alignment subdivision, the missing data is statistically modelled in order to retain as many sequences as possible in the phylogenetic analysis. Subdivision resulted in more modest improvements to alignment accuracy, but succeeded in including almost all of the input sequences.
Conclusion
These results demonstrate that partial gene sequences and gappy multiple sequence alignments can pose a major problem for phylogenetic analysis. The concern will be greatest for high-throughput phylogenomic analyses, in which Neighbor Joining is often the preferred method due to its computational efficiency. Both approaches can be used to increase the accuracy of phylogenetic inference from a gappy alignment. The choice between the two approaches will depend upon how robust the application is to the loss of sequences from the input set, with alignment masking generally giving a much greater improvement in accuracy but at the cost of discarding a larger number of the input sequences.
Background: Haplotype inference based on unphased SNP markers is an important task in population genetics. Although there are different approaches to the inference of haplotypes in diploid species, the existing software is not suitable for inferring haplotypes from unphased SNP data in polyploid species, such as the cultivated potato (Solanum tuberosum). Potato species are tetraploid and highly heterozygous.
Results: Here we present the software SATlotyper which is able to handle polyploid and polyallelic data. SATlo-typer uses the Boolean satisfiability problem to formulate Haplotype Inference by Pure Parsimony. The software excludes existing haplotype inferences, thus allowing for calculation of alternative inferences. As it is not known which of the multiple haplotype inferences are best supported by the given unphased data set, we use a bootstrapping procedure that allows for scoring of alternative inferences. Finally, by means of the bootstrapping scores, it is possible to optimise the phased genotypes belonging to a given haplotype inference. The program is evaluated with simulated and experimental SNP data generated for heterozygous tetraploid populations of potato. We show that, instead of taking the first haplotype inference reported by the program, we can significantly improve the quality of the final result by applying additional methods that include scoring of the alternative haplotype inferences and genotype optimisation. For a sub-population of nineteen individuals, the predicted results computed by SATlotyper were directly compared with results obtained by experimental haplotype inference via sequencing of cloned amplicons. Prediction and experiment gave similar results regarding the inferred haplotypes and phased genotypes.
Conclusion: Our results suggest that Haplotype Inference by Pure Parsimony can be solved efficiently by the SAT approach, even for data sets of unphased SNP from heterozygous polyploids. SATlotyper is freeware and is distributed as a Java JAR file. The software can be downloaded from the webpage of the GABI Primary Database at http://www.gabipd.org/projects/satlotyper/. The application of SATlotyper will provide haplotype information, which can be used in haplotype association mapping studies of polyploid plants.
GeneFisher-P
(2008)
Background: PCR primer design is an everyday, but not trivial task requiring state-of-the-art software. We describe the popular tool GeneFisher and explain its recent restructuring using workflow techniques. We apply a service-oriented approach to model and implement GeneFisher-P, a process-based version of the GeneFisher web application, as a part of the Bio-jETI platform for service modeling and execution. We show how to introduce a flexible process layer to meet the growing demand for improved user-friendliness and flexibility.
Results: Within Bio-jETI, we model the process using the jABC framework, a mature model-driven, service-oriented process definition platform. We encapsulate remote legacy tools and integrate web services using jETI, an extension of the jABC for seamless integration of remote resources as basic services, ready to be used in the process. Some of the basic services used by GeneFisher are in fact already provided as individual web services at BiBiServ and can be directly accessed. Others are legacy programs, and are made available to Bio-jETI via the jETI technology.
The full power of service-based process orientation is required when more bioinformatics tools, available as web services or via jETI, lead to easy extensions or variations of the basic process. This concerns for instance variations of data retrieval or alignment tools as provided by the European Bioinformatics Institute (EBI).
Conclusions: The resulting service-and process-oriented GeneFisher-P demonstrates how basic services from heterogeneous sources can be easily orchestrated in the Bio-jETI platform and lead to a flexible family of specialized processes tailored to specific tasks.