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This paper reads ‘The Detainee’s Tale as told to Ali Smith’ (2016) as an exemplary demonstration of the work of world literature. Smith’s story articulates an ethics of reading that is grounded in the recipient’s openness to the singular, unpredictable, and unverifiable text of the other. More specifically, Smith’s account enables the very event that it painstakingly stages: the encounter with alterity and newness, which is both the theme of the narrative and the effect of the text on the reader. At the same time, however, the text urges to move from an ethics of literature understood as the responsible reception of the other by an individual reader to a more explicitly convivial and political ethics of commitment beyond the scene of reading.
While W.E.B. Du Bois’s first novel, The Quest of the Silver Fleece (1911), is set squarely in the USA, his second work of fiction, Dark Princess: A Romance (1928), abandons this national framework, depicting the treatment of African Americans in the USA as embedded into an international system of economic exploitation based on racial categories. Ultimately, the political visions offered in the novels differ starkly, but both employ a Western literary canon – so-called ‘classics’ from Greek, German, English, French, and US American literature. With this, Du Bois attempts to create a new space for African Americans in the world (literature) of the 20th century. Weary of the traditions of this ‘world literature’, the novels complicate and begin to decenter the canon that they draw on. This reading traces what I interpret as subtle signs of frustration over the limits set by the literature that underlies Dark Princess, while its predecessor had been more optimistic in its appropriation of Eurocentric fiction for its propagandist aims.
Paths Are Made by Walking
(2021)
Introduction
(2021)
This edited volume examines entanglements and disentanglements between Africa and East Germany during and after the Cold War from a global history perspective. Extending the view beyond political elites, it asks for the negotiated and plural character of socialism in these encounters and sheds light on migration, media, development, and solidarity through personal and institutional agency. With its distinctive focus on moorings and unmoorings, the volume shows how the encounters, albeit often brief, significantly influenced both African and East German histories.
Hintergrund. Personen, die mit der chronischen Erkrankung HIV leben (PWH), müssen ihr Leben lang die sog. antiretrovirale Therapie (ART) einnehmen, um einen Ausbruch der Erkrankung in das Vollbild AIDS (Akquiriertes Immun-Defizienz-Syndrom) zu vermeiden. Gleichzeitig ist die ART und HIV selbst assoziiert mit dem Auftreten zusätzlicher Erkrankungen (Komorbiditäten) kardiovaskulärer oder psychologischer Natur. Die Prävalenz von Komorbiditäten und schlechter Lebensqualität ist im Vergleich zu HIV-negativen Personen deutlich höher.
Methoden. Es wurden zwei Metaanalysen zu sportlicher Betätigung, PWH und (1) kardiovaskulären und (2) psychologischen Parametern sowie eine Querschnittsstudie (HIBES-Studie, HIV-Begleiterkrankungen und Sport) durchgeführt. Für die Auswertung der metaanalytischen Daten wurde der Review Manager 5.3, für die Auswertung der Daten der HIBES-Studie das Analyseprogramm „R“ verwendet. In den Metaanalysen wurden, neben den Hauptanalysen verschiedener Parameter, erstmals spezifische Subgruppenanalysen durchgeführt. Die HIBES-Studie untersuchte Unterschiede zwischen kumulativen (2-3 verschiedenen Sportarten pro Woche) und einfachen (eine Sportart pro Woche) Freizeitsport und analysiert die Zusammenhänge von Parametern des Freizeitsports (Trainingshäufigkeit, -Minuten und –Intensität), Komorbiditäten und der Lebensqualität.
Ergebnisse. Ausdauer- und Krafttraining haben einen mittel-starken bis starken positiven Effekt auf die maximale Sauerstoffaufnahme (SMD= 0.66, p< .00001), den 6-Minuten-Walk-Test (6MWT) (SMD= 0.59, p= .02), die maximale Watt Zahl (SMD= 0.80, p= .009). Kein Effekt wurde bei der maximalen Herzfrequenz und dem systolischen sowie diastolischen Blutdruck gefunden. Subgruppenanalysen zu ≥3 Einheiten/Woche, ≥150 Min./Woche ergaben hohe Effektstärken in der maximalen Watt Zahl und 6MWT. Ausdauer- und Krafttraining zusammen mit Yoga haben einen starken Effekt auf Symptome der Depression (SMD= -0.84, p= .02) und Angststörungen (SMD= -1.23, p= .04). Die Subanalyse der Depression zu professioneller Supervision und sportlicher Betätigung wiesen einen sehr starken Effekt (SMD= -1.40, p= .03). Die HIBES-Studie wies ein sehr differenziertes Bild im Sportverhalten von PWH in Deutschland auf. 49% der Teilnehmer übten mehr als eine Sportart pro Woche aus. Es wurden keine Unterschiede zwischen kumuliertem (CTE) und einfachem Sport (STE) in der Lebensqualität gefunden. Die Freizeitsportparameter (Häufigkeiten/Woche, Minuten/Woche, Intensität/Woche) waren in der CTE-Gruppe deutlich höher als in der STE-Gruppe. Trainingsminuten und die -Intensität zeigten beim Vorhandensein einer Komorbidität einen großen Zusammenhang mit der Lebensqualität. Die Minuten und die Intensität des durchgeführten Sportes zeigten einen prädiktiven Zusammenhang mit der Lebensqualität.
Konklusion: Sportliche Betätigung verbessert die maximale Sauerstoffaufnahme und Symptome der Depression und Angststörungen. Die Aussagekraft der Subanalysen ist aufgrund der geringen Studienzahl, vorsichtig zu interpretieren. Erhöhte Trainingsparameter finden sich eher bei PWH, die mehr als eine Sportart pro Woche treiben. Daher kann kumulierter Sport als mediierender Faktor zur Steigerung der Lebensqualität interpretiert werden; zumindest bei PWH mit einer psychologischen Komorbidität.
Simultaneously speculative and inspired by everyday experiences, this volume develops an aesthetics of metabolism that offers a new perspective on the human-environment relation, one that is processual, relational, and not dependent on conscious thought. In art installations, design prototypes, and researchcreation projects that utilize air, light, or temperature to impact subjective experience the author finds aesthetic milieus that shift our awareness to the role of different sense modalities in aesthetic experience. Metabolic and atmospheric processes allow for an aesthetics besides and beyond the usually dominant visual sense.
Blutige Enthaltung
(2021)
Die Militärhistoriker Sönke Neitzel und Matteo Scianna legen die erste historische Darstellung und Analyse der deutschen Syrienpolitik seit 2011 vor. Sie legen die Probleme einer Außenpolitik offen, die für die katastrophale Lage in Syrien und die großen Flüchtlingsbewegungen von dort mit verantwortlich ist. Neitzel und Scianna konstatieren eine Diskrepanz zwischen der wirtschaftlichen Macht und der Bereitschaft, einer gewachsenen politischen Verantwortung im internationalen Krisenmanagement gerecht zu werden – zumal in Fällen, in denen ein militärisches Eingreifen gefragt wäre. Die Autoren betrachten den Syrienkrieg als ein Beispiel, um die Haltung Deutschlands in internationalen Krisen und seine Rolle bei deren Bewältigung kritisch zu beleuchten. Ihr Fazit: Es fehlt hierzulande eine strategische Kultur im Umgang mit den wachsenden internationalen Konflikten. Stattdessen versucht sich die deutsche Außenpolititk möglichst aus der Affäre zu ziehen.
This article is a discussion of Plin. Ep. 7.29 and Ep. 8.6, in which he presents his reaction to seeing the grave monument of Marcus Antonius Pallas, the freedman and minister of the Emperor Claudius, beside the Via Tiburtina. The monument records a senatorial vote of thanks to Pallas, and Pliny expresses intense indignation at the Senate’s subservience and at the power and influence wielded by a freedman. This article compares Pliny’s letters with Tacitus’ account of the senatorial vote of thanks to Pallas at Ann. 12.52–3 and explores the differences between the ways in which the two authors encourage readers to relate to past events. It is noted that the Pallas letters are unusual amongst Pliny’s let- ters for their treatment of material unconnected with the life and career of Pliny and his friends, and argued that in Ep. 7.29 Pliny uses language and attitudes drawn from satire to evoke the past. Ep. 8.6 is read as an idiosyncratic piece of historical enquiry, consider- ing Pliny’s use of citation and his anonymization of historical individuals. Both letters are considered in the context of the surrounding letters, and a hypothesis is offered regarding the identity of their addressee Montanus, considering evidence from Tacitus’ Histories and Annals. Discussion of Tac. Ann. 12.52–3 focusses on the use of irony. Pliny’s evocation of enargeia (‘vividness’) is compared with that of Tacitus. The article concludes with comparison of the historical accounts offered by Pliny and Tacitus through reflection on Juvenal, Satire 1.
Die Rechtsfolgen einer fehlgeschlagenen Anteilsabtretung stellen ein rechtspraktisches Problem des GmbH-Rechts dar, dessen Lösungswege üblicherweise im Schuldrecht gesucht werden. Der Anwendung der schuldrechtlichen Rechtsinstitute im Rahmen des § 16 Abs. 1 GmbHG geht die Frage voran, ob das durch die Legitimationswirkung charakterisierte Auseinanderfallen von Herrschaftsrecht und Herrschaftsmöglichkeit zur Anwendung des Eigentümer-Besitzer-Verhältnisses führen kann. Der Übertragbarkeit der drei Komponenten der Vindikationslage – Sache, Eigentum, Besitz – und deren Interdependenzen auf die durch die Legitimationswirkung hervorgerufene Situation widmet sich diese Arbeit. Im Wege des systematischen Vergleichs der Rechtsbeziehungen weist der Autor eine Vergleichbarkeit nach und schlägt eine analoge Anwendung des Eigentümer-Besitzer-Verhältnisses vor. Im Mittelpunkt stehen die Rechtsgegenständlichkeit der Mitgliedschaft und die Ausdehnung des Besitzbegriffs auf unkörperliche Rechtsprodukte.
Strafrecht, Besonderer Teil
(2021)
Strafrecht, Besonderer Teil
(2021)
Das Lehrbuch behandelt die für Studium und Examen bedeutsamen Verbrechen und Vergehen aus dem Bereich der Nichtvermögensdelikte, wobei stets auch die Bezüge zum Allgemeinen Teil aufgezeigt werden. Die Darstellung erfolgt durchgehend anhand von Fällen und Beispielen und enthält eingehende Problembehandlungen. Band 1 bildet zusammen mit dem ebenfalls neu bearbeiteten Studienbuch Krey/Hellmann/Heinrich, Besonderer Teil, Band 2 (zu den Vermögensdelikten) ein gründliches und aktuelles Standardwerk zum Besonderen Teil. Das Buch richtet sich an Anfänger, denen es eine gründliche Einführung bietet, aber auch an Fortgeschrittene, Referendare und Praktiker zur Wiederholung, Ergänzung und Vertiefung.
En apenas tan pocas lenguas, como en el español, se ha publicado tantos trabajos sobre la evidencialidad en los últimos años. No obstante, en ello se pierde de vista con frecuencia la verdadera función de los marcadores de evidencialidad que hacen referencia al origen del conocimiento del hablante. Además de los marcadores léxicos, se consideran como medios de expresión de la evidencialidad incluso estructuras discursivas y expresiones proposicionales que hacen referencia a la fuente del conocimiento, alejándose demasiado de la restricción a los evidenciales gramaticales. En esta contribución, se intentará ordenar esta posición confusa y desarrollar un modelo de relación entre la evidencialidad y temporalidad, aspectualidad y modalidad que tenga en cuenta la realidad de las circunstancias en el español y sus variedades. Se partirá de un planteamiento onomasiológico hacia los medios de expresión del origen del conocimiento del hablante; al mismo tiempo se analizarán los medios de expresión en cuanto a su polifuncionalidad. La base empírica para este estudio será el análisis de un corpus (SketchEngine, CREA, CORPES XXI) sobre el condicional reportativo e inferencial y su relación con el imperfecto evidencial y futuro inferencial en las diversas variedades del español, así como las condiciones de uso de los adverbios evidenciales-epistémicos.
Die vorliegende Arbeit beschäftigt sich mit der Synthese von Disulfiden, der Thiol-Disulfid Metathesereaktion als Möglichkeit, Polymere zu funktionalisieren, und der Synthese von Polydisulfiden. Im ersten Teil der Arbeit wird die Aminolyse von RAFT-Polymeren und die Abhängigkeit der Polymer-Polymer Disulfidbildung von der Molmasse untersucht. Dabei wurde durch die Aufnahme von Reaktionskinetiken mittels Gel-Permeations-Chromatographie (GPC) festgestellt, dass je länger die Polymerketten sind, desto weniger Disulfid Polymerkopplung tritt auf. RAFT-Polymere werden oft genutzt, um die RAFT-Polymer Endgruppe nach der Polymerisation zu modifizieren oder in einer chemischen Reaktion zu funktionalisieren. Hier kann die Aminolyse in Anwesenheit von kurzkettigen Disulfiden, wie zum Beispiel Cystin, durchgeführt werden, um die Bildung von Polymer-Polymer Disulfiden vollständig zu unterdrücken und ein endgruppenfunktionalisiertes Polymer zu erhalten. Bei dieser Reaktion greift das bei der Aminolyse entstehende Polymerthiolat die kurzkettigen Disulfide an, und es kommt zur Bildung von funktionalisierten Polymeren. Es wurde ein Polyethylenglykoldisulfid eingesetzt, um ein amphiphiles Blockcopolymer zu erhalten. Als RAFT-Polymer wurde Polystyrol (PS) verwendet, und es konnte die Bildung von Polystyrol-Polyethylenglykol Copolymeren nachgewiesen werden. Das amphiphile Polymer bildet im wässrigen Medium Vesikel. Die Oberfläche der Vesikel konnte mittels der Thiol-Disulfid Metathese umfunktionalisiert werden. Die Aminolyse von PS RAFT-Polymeren mit einem Polylaktiddisulfid oder einem Polybenzylglutamatdisulfid ergab Polystyrol-block-Polyester und Polystyrol-block-Polyaminosäuren Copolymere. Im zweiten Teil der Arbeit liegt der Fokus auf der Synthese von Polydisulfiden und ihren thermischen Eigenschaften. Es wurden verschiedene Alkyldithiole synthetisiert und mittels Wasserstoffperoxid und Triethylamin polymerisiert. Dabei konnte gezeigt werden, dass die Polymere teilkristallin sind und dass der Schmelzpunkt und die Kristallinität der Polymere mit steigender Alkylkettenlänge zwischen den Disulfidbindungen zunehmen. Die Möglichkeit einer Polymerkettenerweiterung nach der Polymerisation ist mit diesem System gegeben. Die Abbaubarkeit der Polydisulfide konnte durch den Einsatz von Thiolen im basischen Milieu gezeigt werden.
Feminismus - das ist nicht nur für Männer, sondern auch für einige Frauen immer noch ein bedrohliches Wort, selbst oder gerade in Zeiten von #MeToo. Liegt das daran, dass viele gar nicht wissen, was Feminismus ist und worauf er hinarbeitet? Gibt es den einen Feminismus? Was hat Feminismus eigentlich mit Sexismus zu tun? Und was mit unseren Beziehungen? Offener Frauenhass ist in unserer Gesellschaft mittlerweile weitgehend geächtet. Aber auch nach über fünfzehn Jahren mit einer Frau an der Regierungsspitze sind wir noch längst nicht in der Gleichberechtigung angekommen. Im Gegenteil: Weiterhin strukturiert Sexismus geschlechtsspezifische Alltagserfahrungen, bis hinein in unsere Intimbeziehungen, wo die Grenzen zwischen Lust und sexueller Gewalt schnell verschwimmen. Die Philosophin und Schriftstellerin Hilkje Hänel deckt die Mechanismen sexueller Objektifizierung und männlichen Anspruchsdenkens auf. Sie zeigt, wie Frauen oft in die sexistischen Alltagsstrukturen verstrickt sind, an denen auch viele Männer leiden. Ihr zugängliches Buch ist das Plädoyer für einen Feminismus, von dem alle etwas haben - und vor dem niemand Angst haben muss.
Devotio malefica
(2021)
Antike Fluchrituale zielten darauf ab, die jeweilige Gerechtigkeitsvorstellung der Verfluchenden durchzusetzen – insbesondere wenn weder das öffentliche Justizsystem noch gesellschaftlich anerkannte Verhaltenskodize dem Anspruch gerecht werden konnten. In den Ritualen kamen sogenannte defixionis tabellae (Fluchtafeln) zur Anwendung, die hier devotiones maleficae genannt werden. Sie bestehen meistens aus eingeschriebenen Bleilamellen und wurden für die Beschädigung eines oder mehrerer Opfer angefertigt.
Sara Chiarini untersucht die dabei verwendete Fluchsprache, die durch ihre formelhaften Strukturen und Bestandteile auf eine Tradition des Fluchrituals hindeuten. Individuelle Ergänzungen bieten hingegen Hinweise auf die Bedingungen um die Entstehung des Rituals, die Gefühlslage der Verfluchenden und die Arten von Bestrafungen, die der rechtlichen Dimension des Rituals entsprechen. Chiarini ergänzt den bisherigen Forschungstand anhand der neu entdeckten und veröffentlichten Fluchtafeln und setzt sich umfassend mit diesem epigraphischen Material auseinander.
Kartellrecht
(2021)
This work journal recounts the experiences of a project undertaken with students of the University of Trier over the course of two semesters. The project attempted to design and produce an innovative audio guide pertaining to the cultural heritage of the Roman city, with students gauging market opportunities, writing a business plan, researching information and producing content for the audio guide. The work created, „Talking Stones“ (https://www.talking-stones.de/), takes the listener on a tour of Roman Trier embedded in a literary narrative and is available via download on Google Play and the Apple App Store.
In her writings on ancient myth, the British author Natalie Haynes moves women to the centre of attention. Her two latest books, A Thousand Ships and Pandora’s Jar – a fiction novel and a non-fiction one – approach this topic from two different perspectives. This interview takes stock of Haynes’ motives and methodology as well as of the challenges she faces in the process of writing.
Interview with Alana Jelinek
(2021)
Alana Jelinek is an art historian and artist — “an artist making art, and also writing about art”, in her words — , a former European Research Council artist in residence at the Museum of Anthropology and Archaeology at the University of Cambridge, and currently teaching in the School of Creative Arts at the University of Hertfordshire. Her art has revolved mostly around the issues of post- and neocolonialism and their connections with neoliberalism — a more implicit topic in her works from the 1990s on the “tourist gaze” developed into an interest in museums, collecting and ethnography throughout the past two decades. In this interview, she talks to thersites about the role of classical heritage and ancient art in her own work.
This article focuses on the feminist reception of Zenobia of Palmyra in Great Britain during the long nineteenth century and the early twentieth century. A special focus lies on her reception by the British suffragettes who belonged to the Women’s Social and Political Union. Even though Zenobia’s story did not end happily, the warrior queen’s example served to inspire these early feminists. Several products of historical culture – such as books, pieces of art, newspaper articles and theatre plays – provide insight into the reception of her as an historical figure, which is dominated by the image of a strong and courageous woman. The article will shed light on how exactly Zenobia’s example was instrumentalised throughout the first feminist movement in Britain.
Application areas and drugs of Egyptian, Greek and Roman medi-cine are popular references of research in the field of recent aes-thetic dermatology. There, Cleopatra VII is referred to as “mother of chemical peeling” because she is said to have bathed in donkey’s milk. Although extremely popular, there is no ancient source sup-porting Cleopatra’s bath in milk. Nevertheless, Poppaea Sabina, the second wife of Emperor Nero, is said to has bathed in donkey’s milk to beautify her skin. The aim of the paper is to reconstruct the genesis and develop-ment of the modern myth of Cleopatra bathing in donkey’s milk. The origin of this myth can be traced back to the cinema of the 1930s. The result is that in the person of the actress Claudette Colbert her two roles as Cleopatra and Poppaea converged. This convergence was the basis for the popularization of the milk bath by the Cleopat-ra movie of 1963 with Elizabeth Taylor.
Ruhm, Ide(ologi)e, Macht
(2021)
The first Hollywood film adaptation of Alexander the Great is Robert Rossen’s 1956 movie. Classicists have primarily been concerned with errors of historicity, Alexander’s assumed tragic traits, and rather associative conclusions concerning the movie’s political implications.
This paper raises the question of Rossen’s depiction of Alexander's motives and aims. His assessment of the king is surprisingly complicated. Therefore, for the first time, Rossen's interview comments on Alexander are analysed comprehensively and systematically. Furthermore, it is shown that neglected sources are central to the plot. Finally, the film is interpreted against the backdrop of Rossen’s oeuvre.
It can be demonstrated that Rossen’s issue is the problem of ideology. He seeks a redefinition of glory. Military success is only an excuse for the pursuit of mere power. For Rossen, however, the true fame is nothing but the benefit of the people. It took a long time for Alexander to realize that his rule was inane, and to reshape his policy. This interpretation is due to fundamental convictions reflected in Rossen’s oeuvre as well as to his personal experiences in politics. It is a plea for de-ideologization in times of the Cold War.
Spring Issue
(2021)
Probleme Jüdischer Theologie
(2021)
Der Aufsatz behandelt die drei unterschiedlichen Hinrichtungsformen, die im 5. und 4. Jahrhundert v. Chr. in Athen angedroht wurden: apotympanismós , Sturz ins Barathron und Schierling. Eine solche Untersuchung verspricht reichen Aufschluss über die demokratische Ideologie, die entsprechenden Diskurse und ihre stetige Verstärkung durch Prozesse und Bestrafungen. Der Aufsatz vertritt dabei die These, dass eine chronologische Analyse dieser Hinrichtungsformen einen wichtigen und bisher unerforschten Beitrag zur Debatte über Kontinuität und Diskontinuität in der athenischen Demokratie vor und nach der Tyrannis der Dreißig leisten kann. Er zeigt, dass die Formen, in denen die Todesstrafe angedroht wurde, das Ausmaß der Änderungen in den Diskursen in der und über die athenische Demokratie nach der Niederlage im Peloponnesischen Krieg erkennen lässt. Die Unterschiede in den Exekutionsformen können einen wichtigen Beitrag zum Verständnis der Verschiebung des Begriffes der „Gleichheit“ vom 5. ins 4. Jahrhundert v. Chr. leisten.
Un changement de la fonction de la périphrase verbale espagnole estar+gérondif a été reconnu depuis longtemps. Déjà Gili Gaya (1948: 114) avait mentionné la construction suivante et il l’avait expliquée par l’influence exercée par des manuels de correspondance commerciale traduits de l’anglais : Estamos enviándole esta carta para comunicarle [...] au lieu de: Le enviamos esta carta […]. Comme en anglais, on trouve la périphrase espagnole estar+gérondif avec des significations non-actionnelles et futures dans les corpus CREA et CORPES XXI de la Real Academia Española et dans le Corpus del español (Cuando el reloj dé las dos, estaré llamando por teléfono. Ahora está hablando el presidente.). Cette périphrase est fortement grammaticalisée avec la signification aspectuelle et son apparition dans de nouveaux contextes est un phénomène intéressant qu’on pourrait expliquer partiellement par le contact avec la langue anglaise. Dans le portugais brésilien, le même phénomène apparaît, tandis qu’il est absent dans le portugais européen. Les exemples trouvés dans le Corpus do português expriment des déclarations d’intentions ou des promesses qui seront réalisées dans le futur (O qual eu acho isso totalmente errado! Pois estou fazendo novamente um plano de negócios).
Il était surprenant de constater le même phénomène de l’emploi comme expression de situations futures pour la périphrase française être en train de dans des variétés parlées en Amérique du Nord. Dans le corpus FRAN (<http://continent.uottawa.ca/fr/corpus-et-ressources-electroniques/corpus/>), cette périphrase apparaît avec une plus grande fréquence que dans des textes comparables en français européen. Dans les occurrences de la périphrase être en train de+infinitif dans le corpus FRAN, on peut constater des phénomènes remarquables: le marquage de l’imperfectivité et de la progressivité dans des cas dans lesquels l’imparfait ou le présent auraient été suffisants (Fait que tu étais en train de me parler donc des nouvelles constructions dans le quartier); l’usage sans auxiliaire et en fonction attributive (des gens en train de parler français), l’usage pour exprimer une action future (cette année euh on est en train de f/ de/ de transcrire). Beaucoup de ruptures après être en train de indiquent la fixité de la construction (là on est en train de euh [phrase non terminée]).
Dans cette contribution, nous partons de la position selon laquelle le marquage de l’aspectualité imperfective est une nécessité qui peut mener à l’usage de moyens d’expression plus suréminents que les temps marqués aspectuellement. Le contact avec une construction de progressivité grammaticalisée peut induire l’usage multiplié de moyens d’expression périphrastiques, contribuer au changement de leur signification et accélérer des processus de grammaticalisation. La base de tous ces changements est un pont cognitif entre la non-délimitation propre à l’aspectualité imperfective et la futurité des situations décrites. L’influence de l’anglais sera décrite comme un phénomène déclencheur d’un changement possible dans toutes les langues romanes qui ont une périphrase d’aspectualité imperfective, même en français où cette périphrase présente une autre structure.
Vertragsgestaltung ist ein praktisch sehr relevantes Thema, das wegen der Justizorientierung in der Wissenschaft noch weitgehend stiefmütterlich behandelt wird. In dieser Untersuchung wird, zumindest für die besonders delikate Konstellation bei komplexen Kooperationen des Staats mit Privaten (ÖPP/PPP), Abhilfe geschaffen. Dabei gründet die Analyse auf einer fundierten Typisierung und Charakterisierung der Probleme solcher Projekte. Den theoretischen Rahmen liefert eine effizienzorientierte Studie institutionenökonomischer Ansätze, namentlich der Transaktionskostentheorie und der Prinzipal-Agenten-Theorie, rückversichert über die praxisorientierten Grundregeln der vertraglichen Risikoverteilung. So gelingt es praktische Formulierungsvorschläge für Standardprobleme der Vertragsgestaltung, wie Leistungsbestimmungen, Anpassungsmechanismen, Konfliktbeilegungsregeln, Informationsmechanismen und Kündigungsregeln zu finden. Diese werden auch aus den Erfolgsbedingungen erläutert.
The suitability of a newly developed cell-based functional assay was tested for the detection of the activity of a range of neurotoxins and neuroactive pharmaceuticals which act by stimulation or inhibition of calcium-dependent neurotransmitter release. In this functional assay, a reporter enzyme is released concomitantly with the neurotransmitter from neurosecretory vesicles. The current study showed that the release of a luciferase from a differentiated human neuroblastoma-based reporter cell line (SIMA-hPOMC1-26-GLuc cells) can be stimulated by a carbachol-mediated activation of the Gq-coupled muscarinic-acetylcholine receptor and by the Ca2+-channel forming spider toxin α-latrotoxin. Carbachol-stimulated luciferase release was completely inhibited by the muscarinic acetylcholine receptor antagonist atropine and α-latrotoxin-mediated release by the Ca2+-chelator EGTA, demonstrating the specificity of luciferase-release stimulation. SIMA-hPOMC1-26-GLuc cells express mainly L- and N-type and to a lesser extent T-type VGCC on the mRNA and protein level. In accordance with the expression profile a depolarization-stimulated luciferase release by a high K+-buffer was effectively and dose-dependently inhibited by L-type VGCC inhibitors and to a lesser extent by N-type and T-type inhibitors. P/Q- and R-type inhibitors did not affect the K+-stimulated luciferase release. In summary, the newly established cell-based assay may represent a versatile tool to analyze the biological efficiency of a range of neurotoxins and neuroactive pharmaceuticals which mediate their activity by the modulation of calcium-dependent neurotransmitter release.
Mental health problems remain among the main generators of costs within and beyond the health care system. Psychotherapy, the tool of choice in their treatment, is qualified by social interaction, and cooperation within the therapist-patient-dyad. Research into the factors influencing therapy success to date is neither exhaustive nor conclusive. Among many others, the quality of the relationship between therapist and patient stands out regardless of the followed psychotherapy school. Emerging research points to a connection between interpersonal synchronization within the sessions and therapy outcome. Consequently, it can be considered significant for the shaping of this relationship. The framework of Embodied Cognition assumes bodily and neuronal correlates of thinking. Therefore, the present paper reviews investigations on interpersonal, non-verbal synchrony in two domains: firstly, studies on interpersonal synchrony in psychotherapy are reviewed (synchronization of movement). Secondly, findings on neurological correlates of interpersonal synchrony (assessed with EEG, fMRI, fNIRS) are summarized in a narrative manner. In addition, the question is asked whether interpersonal synchrony can be achieved voluntarily on an individual level. It is concluded that there might be mechanisms which could give more insights into therapy success, but as of yet remain uninvestigated. Further, the framework of embodied cognition applies more to the current body of evidence than classical cognitivist views. Nevertheless, deeper research into interpersonal physical and neurological processes utilizing the framework of Embodied Cognition emerges as a possible route of investigation on the road to lower drop-out rates, improved and quality-controlled therapeutic interventions, thereby significantly reducing healthcare costs.
Focus on English Linguistics
(2021)
The Arctic environments constitute rich and dynamic ecosystems, dominated by microorganisms extremely well adapted to survive and function under severe conditions. A range of physiological adaptations allow the microbiota in these habitats to withstand low temperatures, low water and nutrient availability, high levels of UV radiation, etc. In addition, other adaptations of clear competitive nature are directed at not only surviving but thriving in these environments, by disrupting the metabolism of neighboring cells and affecting intermicrobial communication. Since Arctic microbes are bioindicators which amplify climate alterations in the environment, the Arctic region presents the opportunity to study local microbiota and carry out research about interesting, potentially virulent phenotypes that could be dispersed into other habitats around the globe as a consequence of accelerating climate change. In this context, exploration of Arctic habitats as well as descriptions of the microbes inhabiting them are abundant but microbial competitive strategies commonly associated with virulence and pathogens are rarely reported. In this project, environmental samples from the Arctic region were collected and microorganisms (bacteria and fungi) were isolated. The clinical relevance of these microorganisms was assessed by observing the following virulence markers: ability to grow at a range of temperatures, expression of antimicrobial resistance and production of hemolysins. The aim of this project is to determine the frequency and relevance of these characteristics in an effort to understand microbial adaptations in habitats threatened by climate change. The isolates obtained and described here were able to grow at a range of temperatures, in some cases more than 30 °C higher than their original isolation temperature. A considerable number of them consistently expressed compounds capable of lysing sheep and bovine erythrocytes on blood agar at different incubation temperatures. Ethanolic extracts of these bacteria were able to cause rapid and complete lysis of erythrocyte suspensions and might even be hemolytic when assayed on human blood. In silico analyses showed a variety of resistance elements, some of them novel, against natural and synthetic antimicrobial compounds. In vitro experiments against a number of antimicrobial compounds showed resistance phenotypes belonging to wild-type populations and some non-wild type which clearly denote human influence in the acquisition of antimicrobial resistance. The results of this project demonstrate the presence of virulence-associated factors expressed by microorganisms of natural, non-clinical environments. This study contains some of the first reports, to the best of our knowledge, of hemolytic microbes isolated from the Arctic region. In addition, it provides additional information about the presence and expression of intrinsic and acquired antimicrobial resistance in environmental isolates, contributing to the understanding of the evolution of relevant pathogenic species and opportunistic pathogens. Finally, this study highlights some of the potential risks associated with changes in the polar regions (habitat melting and destruction, ecosystem transition and re-colonization) as important indirect consequences of global warming and altered climatic conditions around the planet.
Introduction
(2021)
Food intake is driven by the need for energy but also by the demand for essential nutrients such as protein. Whereas it was well known how diets high in protein mediate satiety, it remained unclear how diets low in protein induce appetite. Therefore, this thesis aims to contribute to the research area of the detection of restricted dietary protein and adaptive responses.
This thesis provides clear evidence that the liver-derived hormone fibroblast growth factor 21 (FGF21) is an endocrine signal of a dietary protein restriction, with the cellular amino acid sensor general control nonderepressible 2 (GCN2) kinase acting as an upstream regulator of FGF21 during protein restriction. In the brain, FGF21 is mediating the protein-restricted metabolic responses, e.g. increased energy expenditure, food intake, insulin sensitivity, and improved glucose homeostasis. Furthermore, endogenous FGF21 induced by dietary protein or methionine restriction is preventing the onset of type 2 diabetes in the New Zealand Obese mouse.
Overall, FGF21 plays an important role in the detection of protein restriction and macronutrient imbalance in rodents and humans, and mediates both the behavioral and metabolic responses to dietary protein restriction. This makes FGF21 a critical physiological signal of dietary protein restriction, highlighting the important but often overlooked impact of dietary protein on metabolism and eating behavior, independent of dietary energy content.
Die Erzählungen der Energiewende: Erzählungen beherrschen die Interpretation des politischen Geschehens mehr als formal und methodisch strenge Argumentationsketten. Dies gilt insbesondere für Demokratien. In Demokratien gilt es zu überzeugen und auch zu überreden, um Macht zu erhalten, Macht zu sichern oder Akzeptanz für bestimmte politische Vorhaben zu generieren. Diese simple Feststellung lässt zwei Schlüsse für eine transformativ ausgerichtete Politikwissenschaft zu. Erstens können transformative Narrative produziert werden, die das Auftreten von ökologisch, sozial, ökonomisch und kulturell nachhaltigem wahrscheinlicher machen, Zweitens können die Narrative von nachhaltiger wie nicht-nachhaltiger Transformation analysiert werden. Beiden Aufgaben widmet sich die Dissertationsschrift. Dabei werden für den transformativen Teil ethnografisch erhobene Daten zu fünf transformativen Narrativen verdichtet, die Vorwärts- und Vorbildcharakter haben. In den fünf Aufsätzen wurde auf Diversität zwischen den beschriebenen Protagonisten geachtet, sodass eine breite Leser*innenschaft angesprochen wird. Im analytischen Part wird in einem Aufsatz über diese Vorgehen reflektiert und die Form beschrieben durch die transformative Narrative Wirksamkeit entfalten. Dabei gilt immer, dass die Wissenschaft keine Narrative selbst setzt, sondern mittels nachvollziehbarer Methoden Daten zum Sprechen bringt. Dies ist unter review-Bedingungen gelungen. Neben eines Einsatz von Narrativen in Fragen der Gestaltung der neu entstandenen und weiter entstehenden Energielandschaften behandelt diese Dissertationsschrift a, diskursstrangorientierte als auch institutionsorientierte Erzählungen über die Energiewende. Dabei wurden diskursstrangorientiert die unterschiedlichen Erzählungen der und über energieintensive Unternehmen bezüglich der EEG-Umlage untersucht und kategorisiert und die Metaphern der Energiewende im Magazin DER SPIEGEL erhoben und analysiert. Institutionsorientiert wurde die Energiewendeerzählung der Partei `Alternative für Deutschland´, die Bildsprache des Wirtschaftsministeriums an Hand eines Beispiels sowie die Nachhaltigkeitserzählungen der Zukunftsinstitut GmbH. Schließlich wird nach messbaren Folgen des Nachhaltigkeitsnarrativs in drei Regionen des Rhein-Maas-Gebiets gefragt, was die Arbeit abrunden soll.
History of Forgetfulness
(2021)
Unser modernes Strafrechtsbild ist geprägt von dem Gedanken, dass das Strafrecht den Bürgern ein freies und friedliches Zusammenleben unter Gewährleistung aller verfassungsrechtlich garantierten Grundrechte sichert. Der Einsatz des Strafrechts bedarf der Legitimation und darf nicht aus moralischen Vorstellungen oder Gedanken abgeleitet werden. Strafbar kann es demnach nicht sein, wenn ein Rechtsgutsträger über ein ihm disponibles Rechtsgut frei verfügt. Oftmals stehen hierbei der strafrechtliche Lebensschutz und das Selbstbestimmungsrecht des Einzelnen in einem Spannungsverhältnis.
Die vorliegende Arbeit hat untersucht, wie sich dieses Spannungsverhältnis in der höchstrichterlichen Judikatur entwickelt hat und wie es nunmehr gelöst wird. Konkret stellt sich hierbei die Frage, wie es strafrechtlich bewertet wurde, wenn jemand einen Tötungserfolg mitverursacht hat, der zugleich auf einem freiverantwortlichen Willensentschluss des Opfers beruhte.
Public Character
(2021)
This open access book presents a topical, comprehensive and differentiated analysis of Germany's public administration and reforms. It provides an overview on key elements of German public administration at the federal, Länder and local levels of government as well as on current reform activities of the public sector. It examines the key institutional features of German public administration; the changing relationships between public administration, society and the private sector; the administrative reforms at different levels of the federal system and numerous sectors; and new challenges and modernization approaches like digitalization, Open Government and Better Regulation. Each chapter offers a combination of descriptive information and problem-oriented analysis, presenting key topical issues in Germany which are relevant to an international readership.
Federal Administration
(2021)
The federal administration is significantly small (around 10 percent of all public employees). This speciality of the German administrative system is based on the division of responsibilities: the central (federal) level drafts and adopts most of the laws and public programmes, and the state level (together with the municipal level) implements them. The administration of the federal level comprises the ministries, subordinated agencies for special and selected operational tasks (e.g. the authorisation of drugs, information security and registration of refugees) in distinct administrative sectors (e.g. foreign service, armed forces and federal police). The capacity for preparing and monitoring government bills and statutory instruments is well developed. Moreover, the instruments and tools of coordination are exemplary compared with other countries, although the recent digital turn has been adopted less advanced than elsewhere.
This chapter describes the most prominent public management reform trajectories in German public administration over the past decades since unification. In the 1990s, the New Steering Model emerged as a German variant of the NPM. Since the mid-2000s, local governments in Germany have been subjected to a mandatory reform of their budgeting and accounting system known as the New Municipal Financial Management reforms. Both reforms have led to a substantial change in terms of internal decentralisation, customer orientation, transparency in resource use and the financial situation of administrative bodies. But the emerging reform patterns and their impacts have not replaced the dominance of a strong legalist culture with hierarchical, centralised control. However, in the course of the reforms, a citizen-customer perspective, more participation of citizens and limited application of new management instruments have been accommodated within the persisting bureaucratic system.
Over the last decades, Better Regulation has become a major reform topic at the federal and—in some cases—also at the Länder level. Although the debate about improving regulatory quality and reducing unnecessary burdens created by bureaucracy and red tape date back to the 1960s and 1970s, the introduction by law in 2006 of a new independent institutionalised body for regulatory control at the federal level of government has brought a new quality to the discourse and practice of Better Regulation in Germany. This chapter introduces the basic features of the legislative process at the federal level in Germany, addresses the issue of Better Regulation and outlines the role of the National Regulatory Control Council (Nationaler Normenkontrollrat—NKR) as a ‘watchdog’ for compliance costs, red tape and regulatory impacts.
Although German bureaucracy is typically categorised as Weberian, a clear distinction between politics and administration has never been a defining characteristic of the German political-administrative system. Many close interrelations and interactions between elected politicians and appointed civil servants can be observed at all levels of administration. Higher-ranking civil servants in Germany are used to and generally appreciate the functional politicisation of their jobs, that is their close involvement in all stages of the policy process, from policy formation, goal definition, negotiation within and outside government to the implementation and evaluation of policies. For top positions, therefore, a class of ‘political civil servants’ is a special feature of the German system, and obtaining ‘political craft’ has become an important part of the learning and job experience of higher-ranking civil servants.
German Public Administration
(2021)
The international community of public administration and administrative sciences shows a great interest in the basic features of the German administrative system. The German public administration with its formative decentralisation (called: administrative federalism) is regarded as a prime example of multilevel governance and strong local self-government. Furthermore, over the past decades, the traditional profile of the German administrative system has significantly been reshaped and remoulded through reforms, processes of modernisation and the transformation process in East Germany. Studies on the German administrative system should focus especially on
key institutional features of public administration;
changing relationships between public administration, society and the private sector;
administrative reforms at different levels of the federal system; and
new challenges and modernisation approaches, such as digitalisation, open government and better regulation.
Human resource management (HRM) reform has not been the focus of attention in Germany despite its obvious relevance for effective policy implementation. Although there is a general trend worldwide towards convergence between public and private HRM strategies and practices, management of the workforce in German public administration still remains largely traditional and bureaucratic. This chapter describes and analyses German practices regarding the central functions and elements of HRM such as planning, recruitment, training and leadership. Furthermore, it explores the importance and contribution of public service motivation, performance-related pay and diversity management in the context of German practices. The chapter concludes by highlighting some of the major paradoxes of German public HRM in light of current challenges, such as demographic change, digital transformation and organisational development capabilities.
The chapter analyses recent reforms in the multilevel system of the Länder, specifically territorial, functional and structural reforms, which represent three of the most crucial and closely interconnected reform trajectories at the subnational level. It sheds light on the variety of reform approaches pursued in the different Länder and also highlights some factors that account for these differences. The transfer of state functions to local governments is addressed as well as the restructuring of Länder administrations (e.g. abolishment of the meso level of the Länder administration and of single-purpose state agencies) and the rescaling of territorial boundaries at county and municipal levels, including a brief review of the recently failed (territorial) reforms in Eastern Germany.
The German system of public sector employment (including civil servants and public employees) qualifies as a classical European continental civil service model moulded in traditional forms of a Weberian bureaucracy. Its features include a career-based employment system with entry based on levels of formal qualification. Coordinated by legal frames and centralised collective bargaining, the civil service is, at the same time, decentralised and flexible enough to accommodate regional differences and societal changes. In comparison, the civil service system stands out for its high degrees of professionalism and legal fairness with low levels of corruption or cronyism.
In this introductory chapter, the editors describe the main theoretical basis of analysis of this book and the methodological approach. The core of this book consists of 14 country-specific chapters, which allow a European comparison and show the increasing variance in migration policy approaches within and between European countries. The degree of local autonomy, the level of centralisation and the traditional forms of migration policy are factors that especially influence the possibilities for local authorities to formulate their own integration policies.
This chapter focuses on the relationship between public opinion on migration and its media coverage. Different explanatory models, including individual characteristics, cultural factors and the impact of media and politics, have been proposed to explain public attitudes towards migrants. Understanding the local context is important, as the shares of migrants living in each region and city vary considerably. Providing correct statistical information, stressing the diversity of current migration patterns in Europe and taking part in media and public discussions are ways in which to impact public attitudes at the local level.
The chapter begins with a brief historical overview of Germany’s transition in the twentieth and twenty-first century from a transit and emigration country to one of immigration. The next part of this chapter looks at the challenges and problems facing German immigration policy within a multi-level federal system. Finally, the chapter gives an analysis of some of the trends in German migration policy since the refugee crisis in 2015, such as changes in the party system and in the concepts underlying migration policies to better manage, control and limit immigration to Germany.
As expected, the traditions of national-state migration policies continue to play a very important role, path-dependence in this policy field remains high. The distribution of competences in migration policy and the integration of migrants in the nation states continues to be very different. When implementing integration strategies at grassroots level, the respective policies should be tailored to the profile of both the local migrant community and the native population. Besides better migration management in local administration and the interaction of top-down and bottom-up efforts to integrate migrants is of importance.
This book presents an overview of European migration policy and the various institutional arrangements within and between various actors, such as local councils, local media, local economies, and local civil society initiatives. Both the role of local authorities in this policy field and their cooperation with civil society initiatives or networks are under-explored topics for research. In response, this book provides a range of detailed case studies focusing on the six main groups of national and administrative traditions in Europe: Germanic, Scandinavian, Napoleonic, Southeastern European, Central-Eastern European and Anglo-Saxon.
Digitalisierung ist das Schlagwort unserer Zeit und kaum ein Lebensbereich bleibt davon unberührt. Für den Einzelnen, die Gesellschaft, die Unternehmen und den Staat bietet sie immense Chancen. Die weiterhin nicht überstandene COVID-19-Pandemie führt dazu, dass dem digitalen Wandel in bisher ungeahnter Geschwindigkeit eine enorme praktische Bedeutung zukommt. Vor diesem Hintergrund erfolgt mit der Untersuchung ein Rechtsvergleich der Besteuerungsverfahren Österreichs und Deutschlands. Ziel ist es, über das Verfahren im Nachbarland zu informieren und die Unterschiede zum deutschen Recht pointiert herauszuarbeiten. Für Deutschland resultiert daraus die Chance, Konzepte und Lösungen der österreichischen Finanzverwaltung bei der Fortentwicklung von E-Government auszuwerten und sowohl von den positiven wie auch negativen Erfahrungen zu profitieren. So können konkrete Reformvorschläge für das deutsche Besteuerungsverfahren erarbeitet und die daraus resultierenden Chancen dargestellt werden.
Die Gestaltungsfreiheit des Steuerpflichtigen steht in einem Spannungsverhältnis zu einer effektiven Missbrauchsbekämpfung durch den Gesetzgeber. Besonders ausgeprägt ist dieses im Bereich der steuerlichen Verlustnutzung. Dabei gerät die verfassungsrechtliche Verankerung der Verlustnutzung zunehmend aus dem Blick. Am Beispiel des § 2 Abs. 4 UmwStG untersucht die Arbeit die verfassungsrechtlichen Grenzen von Verlustverrechnungsbeschränkungen. Es wird die enge Verknüpfung zu § 8c KStG herausgearbeitet und die Vorschrift vor dem Hintergrund der europäischen Missbrauchskonzeption beleuchtet. Die gewonnenen Ergebnisse münden in einen Vorschlag für eine Neufassung des § 2 Abs. 4 UmwStG, der nationalen und europäischen Vorgaben Rechnung trägt.
Bundeswehrapotheken
(2021)
„Bundeswehrapotheken" schildert die Entstehung und Entwicklung der Sanitätsmaterialversorgungseinrichtungen der Bundeswehr von ihrer Aufstellung Ende der 1950er Jahre bis in die 2000er Jahre. Anfangs im rechtlichen Sinne noch keine Apotheken, waren diese Einrichtungen damals in erster Linie auf den Kriegsfall ausgerichtet und von sehr begrenzter pharmazeutischer Leistungsfähigkeit.
Heute sind nur noch wenige große Bundeswehrapotheken verblieben, die jedoch hinsichtlich ihrer personellen, materiellen und infrastrukturellen Ausstattung und Möglichkeiten uneingeschränkt zivilen Einrichtungen vergleichbar leistungsfähig sind. Überwiegend mit militärischen Fachleuten besetzt und entsprechend ausgerüstet, können die heutigen Bundeswehrapotheken diese Leistung prinzipiell weltweit erbringen.
Gegliedert nach markanten Zeitabschnitten hat der Autor vor dem Hintergrund der jeweils geltenden politischen und militärischen Rahmenbedingungen sowie der Einsatzgrundsätze der Bundeswehr den Einfluss der jeweiligen rechtlichen, militärischen, gesellschaftlichen und fachlichen Vorgaben sowie prägender Ereignisse herausgearbeitet, eingeordnet und bewertet.
Reciprocal space slicing
(2021)
An experimental technique that allows faster assessment of out-of-plane strain dynamics of thin film heterostructures via x-ray diffraction is presented. In contrast to conventional high-speed reciprocal space-mapping setups, our approach reduces the measurement time drastically due to a fixed measurement geometry with a position-sensitive detector. This means that neither the incident (ω) nor the exit (2θ) diffraction angle is scanned during the strain assessment via x-ray diffraction. Shifts of diffraction peaks on the fixed x-ray area detector originate from an out-of-plane strain within the sample. Quantitative strain assessment requires the determination of a factor relating the observed shift to the change in the reciprocal lattice vector. The factor depends only on the widths of the peak along certain directions in reciprocal space, the diffraction angle of the studied reflection, and the resolution of the instrumental setup. We provide a full theoretical explanation and exemplify the concept with picosecond strain dynamics of a thin layer of NbO2.
Investigation of Sirtuin 3 overexpression as a genetic model of fasting in hypothalamic neurons
(2021)
Sephardim and Ashkenazim
(2021)
Sephardic and Ashkenazic Judaism have long been studied separately. Yet, scholars are becoming ever more aware of the need to merge them into a single field of Jewish Studies. This volume opens new perspectives and bridges traditional gaps. The authors are not simply contributing to their respective fields of Sephardic or Ashkenazic Studies. Rather, they all include both Sephardic and Ashkenazic perspectives as they reflect on different aspects of encounters and reconsider traditional narratives. Subjects range from medieval and early modern Sephardic and Ashkenazic constructions of identities, influences, and entanglements in the fields of religious art, halakhah, kabbalah, messianism, and charity to modern Ashkenazic Sephardism and Sephardic admiration for Ashkenazic culture. For reasons of coherency, the contributions all focus on European contexts between the fourteenth and the nineteenth centuries.
Sephardim and Ashkenazim
(2021)
Premessa
(2021)
Dante e Botticelli
(2021)
Hacker und Haecksen zählen zur Avantgarde der Computerisierung. Seit den späten 1970er-Jahren bildeten sie sich in der Bundesrepublik und in der DDR zu eigensinnigen ComputernutzerInnen mit einschlägigem Wissen heraus. Sie eigneten sich das Medium spielerisch an, schufen Kontakträume und brachten sich so aktiv in den Prozess der Computerisierung ein. Durch ihre Grenzüberschreitungen zeigten sie dabei Chancen und Risiken der Digitalisierung auf.
Julia Gül Erdogan geht der Entstehung der Hackerkulturen in Ost- und Westdeutschland nach. Sie analysiert, wie deren teils subversive Praktiken Machtgefüge in Politik, Wirtschaft und Gesellschaft herausforderten. Zugleich verdeutlicht die Arbeit Gemeinsamkeiten und Unterschiede der frühen sub- und gegenkulturellen Computernutzung in den beiden deutschen Teilstaaten.
"Terrae motus factus est magnus". In diesen und ähnlichen Worten erinnern mittelalterliche Geschichtsschreiber stets an das verspürte Eintreten von Erdbeben. Für die ereignisgeschichtliche Rekonstruktion der historischen Seismizität besitzt das Verständnis, dieser seit dem Frühmittelalter zunehmend standardisiert gebrauchten Narrativen, einen hohen Wert. Daher ist es wichtig, mit den bislang nahezu unerkannt geblieben Intentionen, Vorstellungsstrukturen und Argumentationsstrategien früh- und hochmittelalterlicher Geschichtsschreiber bekannt zu werden. Ausgehend von den antiken Ursprüngen ermittelt diese Arbeit die Bandbreite einer auf "terrae motus" aufbauenden, spezifisch mittelalterlichen Traditionsbildung und setzt sie in den Kontext zum Wissens- und Erfahrungshorizont früh- und hochmittelalterlicher Gelehrter. Erdbeben besaßen ein außerordentliches hermeneutisches Potential für das mittelalterliche Weltverständnis. Somit sind mittelalterliche Erdbebenbeschreibungen hinsichtlich ihrer deskriptiven Qualität und argumentativen Wertigkeit verschieden. Die Historiographie- und Ideengeschichte sowie die seismologische Parametrisierung von mittelalterlichen Erdbeben wird von diesem Wissen gleichermaßen profitieren.
Diabetes is a major public health problem with increasing global prevalence. Type 2 diabetes (T2D), which accounts for 90% of all diagnosed cases, is a complex polygenic disease also modulated by epigenetics and lifestyle factors. For the identification of T2D-associated genes, linkage analyses combined with mouse breeding strategies and bioinformatic tools were useful in the past. In a previous study in which a backcross population of the lean and diabetes-prone dilute brown non-agouti (DBA) mouse and the obese and diabetes-susceptible New Zealand obese (NZO) mouse was characterized, a major diabetes quantitative trait locus (QTL) was identified on chromosome 4. The locus was designated non-insulin dependent diabetes from DBA (Nidd/DBA). The aim of this thesis was (i) to perform a detailed phenotypic characterization of the Nidd/DBA mice, (ii) to further narrow the critical region and (iii) to identify the responsible genetic variant(s) of the Nidd/DBA locus. The phenotypic characterization of recombinant congenic mice carrying a 13.6 Mbp Nidd/DBA fragment with 284 genes presented a gradually worsening metabolic phenotype. Nidd/DBA allele carriers exhibited severe hyperglycemia (~19.9 mM) and impaired glucose clearance at 12 weeks of age. Ex vivo perifusion experiments with islets of 13-week-old congenic mice revealed a tendency towards reduced insulin secretion in homozygous DBA mice. In addition, 16-week-old mice showed a severe loss of β-cells and reduced pancreatic insulin content. Pathway analysis of transcriptome data from islets of congenic mice pointed towards a downregulation of cell survival genes. Morphological analysis of pancreatic sections displayed a reduced number of bi-hormonal cells co-expressing glucagon and insulin in homozygous DBA mice, which could indicate a reduced plasticity of endocrine cells in response to hyperglycemic stress. Further generation and phenotyping of recombinant congenic mice enabled the isolation of a 3.3 Mbp fragment that was still able to induce hyperglycemia and contained 61 genes. Bioinformatic analyses including haplotype mapping, sequence and transcriptome analysis were integrated in order to further reduce the number of candidate genes and to identify the presumable causative gene variant. Four putative candidate genes (Ttc39a, Kti12, Osbpl9, Calr4) were defined, which were either differentially expressed or carried a sequence variant. In addition, in silico ChIP-Seq analyses of the 3.3 Mbp region indicated a high number of SNPs located in active regions of binding sites of β-cell transcription factors. This points towards potentially altered cis-regulatory elements that could be responsible for the phenotype conferred by the Nidd/DBA locus. In summary, the Nidd/DBA locus mediates impaired glucose homeostasis and reduced insulin secretion capacity which finally leads to β-cell death. The downregulation of cell survival genes and reduced plasticity of endocrine cells could further contribute to the β-cell loss. The critical region was narrowed down to a 3.3 Mbp fragment containing 61 genes, of which four might be involved in the development of the diabetogenic Nidd/DBA phenotype.
‘Smart’ Janus emulsions
(2021)
Emulsions constitute one of the most prominent and continuously evolving research areas in Colloid Chemistry, which involves the preparation of mixtures or dispersions of immiscible components in a continuous medium. Besides conventional oil-in-water or water-in-oil emulsions, other emulsions of complex droplet morphologies have recently attracted significant research interests. Especially Janus emulsions, in which each droplet is comprised of two distinct sub-regions, have shown versatile potential applications. One of their advantages is the possibility of compartmentalization, which enables to play with two different chemistries in a single droplet. Though microfluidic methods are conventionally used to prepare Janus emulsions, their industrial applications are largely hindered by low throughput and extensive instrumentations. Recently, it has been discovered that simply one-pot moderate/high energy emulsification is also capable of developing Janus morphology, although their preparation and stabilization remain rather substantially challenging. This cumulative doctoral thesis focuses on the preparation and characterization of ‘smart’ Janus emulsions, i.e. Janus emulsions with special stimuli-responsive features. One-step moderate/high energy emulsification of olive and silicone oil in an aqueous medium was carried out. Special consideration was devoted to the interfacial tensions among the components to maintain the criteria of forming characteristic droplet architectures, in addition to avoiding multiple emulsion destabilization phenomena like imminent phase separation or even separated droplet formation. A series of investigations were conducted related to the formation of complexes of charged macromolecules and role of them as stabilizers to achieve stable Janus emulsions for a realistic timeframe (more than 3 months). The correlation between the size of the stabilizer particles and the droplet size of emulsion was established. Furthermore, it was observed that Janus emulsion gels with interesting rheological properties can be fabricated in the presence of suitable polyelectrolyte complexes. Janus emulsions that could be influenced by pH, temperature or magnetic field were successfully produced in presence of characteristic stimuli-responsive stabilizers. Afterwards, the effect of these changes was studied by different characterization techniques. The size and morphology could be tuned easily by changing the pH. The incorporation of iron oxide magnetic nanoparticles (synthesized separately by a co-precipitation method) to one component of the Janus emulsion was carried out so that the movement and orientation of the complex droplets in aqueous media could be controlled by an external magnetic field. Additionally, temperature-triggered instantaneous reversible breakdown of Janus droplets was also accomplished. The responses of the Janus droplets by the stimuli were well-documented and explained. Another goal of the present contribution was to exploit this special morphological feature of emulsions as a template for producing porous materials. This was demonstrated by the preparation of ultralight magnetic responsive aerogels, utilizing Janus emulsion gels. The produced aerogels also showed the capacity to separate toxic dye from water. To the best of our knowledge, this is the first example of investigation towards batch scale production of Janus emulsion with such special stimuli-responsive properties by a simple bulk emulsification method.
The co-occurrence of warm spells and droughts can lead to detrimental socio-economic and ecological impacts, largely surpassing the impacts of either warm spells or droughts alone. We quantify changes in the number of compound warm spells and droughts from 1979 to 2018 in the Mediterranean Basin using the ERA5 data set. We analyse two types of compound events: 1) warm season compound events, which are extreme in absolute terms in the warm season from May to October and 2) year-round deseasonalised compound events, which are extreme in relative terms respective to the time of the year. The number of compound events increases significantly and especially warm spells are increasing strongly – with an annual growth rates of 3.9 (3.5) % for warm season (deseasonalised) compound events and 4.6 (4.4) % for warm spells –, whereas for droughts the change is more ambiguous depending on the applied definition. Therefore, the rise in the number of compound events is primarily driven by temperature changes and not the lack of precipitation. The months July and August show the highest increases in warm season compound events, whereas the highest increases of deseasonalised compound events occur in spring and early summer. This increase in deseasonalised compound events can potentially have a significant impact on the functioning of Mediterranean ecosystems as this is the peak phase of ecosystem productivity and a vital phenophase.
Compound weather events may lead to extreme impacts that can affect many aspects of society including agriculture. Identifying the underlying mechanisms that cause extreme impacts, such as crop failure, is of crucial importance to improve their understanding and forecasting. In this study, we investigate whether key meteorological drivers of extreme impacts can be identified using the least absolute shrinkage and selection operator (LASSO) in a model environment, a method that allows for automated variable selection and is able to handle collinearity between variables. As an example of an extreme impact, we investigate crop failure using annual wheat yield as simulated by the Agricultural Production Systems sIMulator (APSIM) crop model driven by 1600 years of daily weather data from a global climate model (EC-Earth) under present-day conditions for the Northern Hemisphere. We then apply LASSO logistic regression to determine which weather conditions during the growing season lead to crop failure. We obtain good model performance in central Europe and the eastern half of the United States, while crop failure years in regions in Asia and the western half of the United States are less accurately predicted. Model performance correlates strongly with annual mean and variability of crop yields; that is, model performance is highest in regions with relatively large annual crop yield mean and variability. Overall, for nearly all grid points, the inclusion of temperature, precipitation and vapour pressure deficit is key to predict crop failure. In addition, meteorological predictors during all seasons are required for a good prediction. These results illustrate the omnipresence of compounding effects of both meteorological drivers and different periods of the growing season for creating crop failure events. Especially vapour pressure deficit and climate extreme indicators such as diurnal temperature range and the number of frost days are selected by the statistical model as relevant predictors for crop failure at most grid points, underlining their overarching relevance. We conclude that the LASSO regression model is a useful tool to automatically detect compound drivers of extreme impacts and could be applied to other weather impacts such as wildfires or floods. As the detected relationships are of purely correlative nature, more detailed analyses are required to establish the causal structure between drivers and impacts.
Future Outlook and Scenarios
(2021)
Where is local self-government heading in the future? Among trends identified is firstly an intensification of multilevel, intermunicipal, and cross-border governance. In the future even more of cooperation and coordination among different political and administrative levels will be required. Territorial boundaries have become increasingly incongruent with functional public activities. Secondly, the innovative potential of introducing markets as templates for organisational reform has reached its end. Future reforms will most likely try to adapt market reforms to local public contexts, or even reverse the development. Finally, a tightening of state steering and an increased dependence on state funding to uphold local services is expected. Waves of amalgamations might slow down this process but they will not make financial problems disappear completely.
The digital transformation of the local public sector is an important step towards making local service delivery more citizen-centred and user-oriented. The state of digitalisation in public administration in Germany is, however, well behind the far-reaching hopes associated with this modernisation theme. This chapter will explore the question as to what extent digital tools have been introduced in German local governments, more specifically in local one-stop shops (Bürgerämter), which hurdles local actors face when coping with the digital transformation, and which tools impact on citizens and local employees as well as have unintended effects and dysfunctionalities so far. A comprehensive and standardised survey amongst mayors and heads of staff councils in German municipalities as well as citizens and employees’ surveys and case studies will form the empirical basis of this chapter.
Beyond Charter and Index
(2021)
The Chapter examines the concept of local autonomy in modern European states by analysing theoretical approaches. The classical, deductive approach defines local autonomy mostly through legal, economic and financial conditions, especially by formal structures. This proves to be too weak to define the internal strength of local authorities and their real political-administrative power. A more multidimensional definition of autonomy, including indicators as importance, capacity, as well as discretion and democracy at local level is needed. The authors utilise the indicators, used by the Local Autonomy Index (LAI) developed by Ladner et al. and the European Charter of Local Self-Government to find out what is still missing. The contribution redounds to stimulate the scientific debate on local autonomy in Europe. Until the concept of local autonomy will fit for all European states with extremely differentiated local authorities, the research in this field remains a conceptual and heuristic endeavour. Especially, because local government and democracy are until now territory-based, whereas the reality is one of multilevel and cross-border governance.
All over Europe, cities and municipalities face new and numerous challenges to uphold their unique self-governing role in society. This intriguing reality underscores this volume’s ambition of brightening the future of local self-government. After further elaborating on this relevant background and the approach taken, the first chapter introduces three main dimensions of analysis. They are key to the volume’s subsequent parts on the essence of local government’s autonomy, its transformations in the light of digitalisation, marketisation and amalgamation and, finally, its changing intergovernmental relations concerning supervision and subnational policy-making. This volume covers eight countries, spread over Europe. And so, this introductory chapter ends with highlighting main features of the different local government systems involved.
This book presents new research results on the challenges of local politics in different European countries, including Germany, the Netherlands, the Nordic countries and Switzerland, together with theoretical considerations on the further development and strengthening of local self-government. It focuses on analyses of the most recent developments in local democracy and administration. “Most ‘local government’ books are written by believers. This book is different for its realistic visions of futures of local government. It shows how autonomy, digitalization, marketization, and amalgamation could be functional or dysfunctional, and also how this is affected by links to politics, and impacted by intergovernmental relations. This is a must read for all believers in local government.” —Geert Bouckaert, KU Leuven Public Governance Institute, Belguim “The twenty chapters of this book provide a timely and thought-provoking addition to our understanding of local self-governance in eight countries in Northern and Central Europe. This book was completed shortly before the Corona-crisis crashed in. But the lessons to be learned from this volume will doubtlessly prove important in fully exploiting local government’s potential in facing the challenges of the difficult times ahead.” —Bas Denters, Professor of Public Administration, University of Twente, Netherlands “Very inspiring book that covers the most important aspects of local self-government within a comparative framework. As we might have expected, there is no general trend, no single best model but a variety of functionally equivalent settings and patterns. The book gives insight into the diversity and richness of local government, its very essence, actual challenges and transformations, and puts subnational policy making in a multi-level perspective of governance.” —Andreas Ladner, Professor for Political Institutions and Public Administration at the IDHEAP, University of Lausanne, Switzerland “Covering eight countries, this ambitious volume compares developments in local governments across Europe. Local governments are on the front-line when it comes to responding to wicked issues like climate change and migration, yet face major challenges in terms of financial and human resources. Using rich empirical evidence, the volume presents a nuanced analysis of trends. No one direction emerges for Europe’s local governments, but a rich seam of innovation is revealed covering political participation and public administration alike. Local governments have the potential to engage citizens in meaningful ways and deliver effective and responsive services, but this requires clear local leadership and support rather direction from the centre.”
Grenzland und Sarmatien
(2021)
Leveraging large-deviation statistics to decipher the stochastic properties of measured trajectories
(2021)
Extensive time-series encoding the position of particles such as viruses, vesicles, or individualproteins are routinely garnered insingle-particle tracking experiments or supercomputing studies.They contain vital clues on how viruses spread or drugs may be delivered in biological cells.Similar time-series are being recorded of stock values in financial markets and of climate data.Such time-series are most typically evaluated in terms of time-averaged mean-squareddisplacements (TAMSDs), which remain random variables for finite measurement times. Theirstatistical properties are different for differentphysical stochastic processes, thus allowing us toextract valuable information on the stochastic process itself. To exploit the full potential of thestatistical information encoded in measured time-series we here propose an easy-to-implementand computationally inexpensive new methodology, based on deviations of the TAMSD from itsensemble average counterpart. Specifically, we use the upper bound of these deviations forBrownian motion (BM) to check the applicability of this approach to simulated and real data sets.By comparing the probability of deviations fordifferent data sets, we demonstrate how thetheoretical bound for BM reveals additional information about observed stochastic processes. Weapply the large-deviation method to data sets of tracer beads tracked in aqueous solution, tracerbeads measured in mucin hydrogels, and of geographic surface temperature anomalies. Ouranalysis shows how the large-deviation properties can be efficiently used as a simple yet effectiveroutine test to reject the BM hypothesis and unveil relevant information on statistical propertiessuch as ergodicity breaking and short-time correlations.
Stereoselective [4+2] Cycloaddition of Singlet Oxygen to Naphthalenes Controlled by Carbohydrates
(2021)
Stereoselective reactions of singlet oxygen are of current interest. Since enantioselective photooxygenations have not been realized efficiently, auxiliary control is an attractive alternative. However, the obtained peroxides are often too labile for isolation or further transformations into enantiomerically pure products. Herein, we describe the oxidation of naphthalenes by singlet oxygen, where the face selectivity is controlled by carbohydrates for the first time. The synthesis of the precursors is easily achieved starting from naphthoquinone and a protected glucose derivative in only two steps. Photooxygenations proceed smoothly at low temperature, and we detected the corresponding endoperoxides as sole products by NMR. They are labile and can thermally react back to the parent naphthalenes and singlet oxygen. However, we could isolate and characterize two enantiomerically pure peroxides, which are sufficiently stable at room temperature. An interesting influence of substituents on the stereoselectivities of the photooxygenations has been found, ranging from 51:49 to up to 91:9 dr (diastereomeric ratio). We explain this by a hindered rotation of the carbohydrate substituents, substantiated by a combination of NOESY measurements and theoretical calculations. Finally, we could transfer the chiral information from a pure endoperoxide to an epoxide, which was isolated after cleavage of the sugar chiral auxiliary in enantiomerically pure form.
Nicht im Trüben fischen
(2021)
The present study aims to identify the optimal body-size/shape and maturity characteristics associated with superior fitness test performances having controlled for body-size, sex, and chronological-age differences. The sample consisted of 597 Tunisian children (396 boys and 201 girls) aged 8 to 15 years. Three sprint speeds recorded at 10, 20 and 30 m; two vertical and two horizontal jump tests; a change-of-direction and a handgrip-strength tests, were assessed during physical-education classes. Allometric modelling was used to identify the benefit of being an early or late maturer. Findings showed that being tall and light is the ideal shape to be successful at most physical fitness tests, but the height-to-weight “shape” ratio seems to be test-dependent. Having controlled for body-size/shape, sex, and chronological age, the model identified maturity-offset as an additional predictor. Boys who go earlier/younger through peak-height-velocity (PHV) outperform those who go at a later/older age. However, most of the girls’ physical-fitness tests peaked at the age at PHV and decline thereafter. Girls whose age at PHV was near the middle of the age range would appear to have an advantage compared to early or late maturers. These findings have important implications for talent scouts and coaches wishing to recruit children into their sports/athletic clubs.
This study aimed to compare the training load of a professional under-19 soccer team (U-19) to that of an elite adult team (EAT), from the same club, during the in-season period. Thirty-nine healthy soccer players were involved (EAT [n = 20]; U-19 [n = 19]) in the study which spanned four weeks. Training load (TL) was monitored as external TL, using a global positioning system (GPS), and internal TL, using a rating of perceived exertion (RPE). TL data were recorded after each training session. During soccer matches, players’ RPEs were recorded. The internal TL was quantified daily by means of the session rating of perceived exertion (session-RPE) using Borg’s 0–10 scale. For GPS data, the selected running speed intensities (over 0.5 s time intervals) were 12–15.9 km/h; 16–19.9 km/h; 20–24.9 km/h; >25 km/h (sprint). Distances covered between 16 and 19.9 km/h, > 20 km/h and >25 km/h were significantly higher in U-19 compared to EAT over the course of the study (p = 0.023, d = 0.243, small; p = 0.016, d = 0.298, small; and p = 0.001, d = 0.564, small, respectively). EAT players performed significantly fewer sprints per week compared to U-19 players (p = 0.002, d = 0.526, small). RPE was significantly higher in U-19 compared to EAT (p = 0.001, d = 0.188, trivial). The external and internal measures of TL were significantly higher in the U-19 group compared to the EAT soccer players. In conclusion, the results obtained show that the training load is greater in U19 compared to EAT.