Joints are crucial to laser cutting as they allow making three-dimensional objects; mounts are crucial because they allow embedding technical components, such as motors. Unfortunately, mounts and joints tend to fail when trying to fabricate a model on a different laser cutter or from a different material. The reason for this lies in the way mounts and joints hold objects in place, which is by forcing them into slightly smaller openings. Such "press fit" mechanisms unfortunately are susceptible to the small changes in diameter that occur when switching to a machine that removes more or less material ("kerf"), as well as to changes in stiffness, as they occur when switching to a different material. We present a software tool called springFit that resolves this problem by replacing the problematic press fit-based mounts and joints with what we call cantilever-based mounts and joints. A cantilever spring is simply a long thin piece of material that pushes against the object to be held. Unlike press fits, cantilever springs are robust against variations in kerf and material; they can even handle very high variations, simply by using longer springs. SpringFit converts models in the form of 2D cutting plans by replacing all contained mounts, notch joints, finger joints, and t-joints. In our technical evaluation, we used springFit to convert 14 models downloaded from the web.

Based on the notion that time, space, and number are part of a generalized magnitude system, we assume that the dual-systems approach to temporal cognition also applies to numerical cognition. Referring to theoretical models of the development of numerical concepts, we propose that children's early skills in processing numbers can be described analogously to temporal updating and temporal reasoning.

Evaluating the performance of self-adaptive systems (SAS) is challenging due to their complexity and interaction with the often highly dynamic environment. In the context of self-healing systems (SHS), employing simulators has been shown to be the most dominant means for performance evaluation. Simulating a SHS also requires realistic fault injection scenarios. We study the state of the practice for evaluating the performance of SHS by means of a systematic literature review. We present the current practice and point out that a more thorough and careful treatment in evaluating the performance of SHS is required.

Spherical particles are routinely monitored and described by hydrodynamic diameters determined, e.g., by light scattering techniques. Non-spherical particles such as prolate ellipsoids require alternative techniques to characterize particle size as well as particle shape. In this study, oligo(epsilon-caprolactone) (oCL) based micronetwork (MN) particles with a shape-shifting function based on their shape-memory capability were programmed from spherical to prolate ellipsoidal shape aided by incorporation and stretching in a water-soluble phantom matrix. By applying light microscopy with automated contour detection and aspect ratio analysis, differences in characteristic aspect ratio distributions of non-crosslinked microparticles (MPs) and crosslinked MNs were detected when the degrees of phantom elongation (30-290%) are increased. The thermally induced shape recovery of programmed MNs starts in the body rather than from the tips of ellipsoids, which may be explained based on local differences in micronetwork deformation. By this approach, fascinating intermediate particle shapes with round bodies and two opposite sharp tips can be obtained, which could be of interest, e.g., in valves or other technical devices, in which the tips allow to temporarily encage the switchable particle in the desired position.

Tupaia’s Map is one of the most famous and enigmatic artefacts to emerge from the early encounters between Europeans and Pacific Islanders. It was drawn by Tupaia, an arioi priest, chiefly advisor and master navigator from Ra‘iātea in the Leeward Society Islands in collaboration with various members of the crew of James Cook’s Endeavour, in two distinct moments of mapmaking and three draft stages between August 1769 and February 1770. To this day, the identity of many islands on the chart, and the logic of their arrangement have posed a riddle to researchers. Drawing in part on archival material hitherto overlooked, in this long essay we propose a new understanding of the chart’s cartographic logic, offer a detailed reconstruction of its genesis, and thus for the first time present a comprehensive reading of Tupaia’s Map. The chart not only underscores the extent and mastery of Polynesian navigation, it is also a remarkable feat of translation between two very different wayfinding systems and their respective representational models.

Based on data from the ESA Gaia Data Release 2 (DR2) and several ground-based, multi-band photometry surveys we have compiled an all-sky catalogue of 39 800 hot subluminous star candidates selected in Gaia DR2 by means of colour, absolute magnitude, and reduced proper motion cuts. We expect the majority of the candidates to be hot subdwarf stars of spectral type B and O, followed by blue horizontal branch stars of late B-type (HBB), hot post-AGB stars, and central stars of planetary nebulae. The contamination by cooler stars should be about 10%. The catalogue is magnitude limited to Gaia G < 19 mag and covers the whole sky. Except within the Galactic plane and LMC/SMC regions, we expect the catalogue to be almost complete up to about 1.5 kpc. The main purpose of this catalogue is to serve as input target list for the large-scale photometric and spectroscopic surveys which are ongoing or scheduled to start in the coming years. In the long run, securing a statistically significant sample of spectroscopically confirmed hot subluminous stars is key to advance towards a more detailed understanding of the latest stages of stellar evolution for single and binary stars.

Levy walks are continuous time random walks with spatio-temporal coupling of jump lengths and waiting times, often used to model superdiffusive spreading processes such as animals searching for food, tracer motion in weakly chaotic systems, or even the dynamics in quantum systems such as cold atoms. In the simplest version Levy walks move with a finite speed. Here, we present an extension of the Levy walk scenario for the case when external force fields influence the motion. The resulting motion is a combination of the response to the deterministic force acting on the particle, changing its velocity according to the principle of total energy conservation, and random velocity reversals governed by the distribution of waiting times. For the fact that the motion stays conservative, that is, on a constant energy surface, our scenario is fundamentally different from thermal motion in the same external potentials. In particular, we present results for the velocity and position distributions for single well potentials of different steepness. The observed dynamics with its continuous velocity changes enriches the theory of Levy walk processes and will be of use in a variety of systems, for which the particles are externally confined.

Purpose The purpose of this paper is to investigate whether and how evolving ideas about management control (MC) emerge in research about public sector performance management (PSPM). Design/methodology/approach This is a literature review on PSPM research through using a set of key terms derived from a review of recent developments in MC. Findings MC research, originating in the management accounting discipline, is largely disconnected from PSPM research as part of public administration and public management disciplines. Overlaps between MC and PSPM research are visible in a cybernetic control approach, control variety and contingency-based reasoning. Both academic communities share an understanding of certain issues, although under diverging labels, especially enabling controls or, in a more general sense, usable performance controls, horizontal controls and control packaging. Specific MC concepts are valuable for future PSPM research, i.e. trust as a complement of performance-based controls in complex settings, and strategy as a variable in contingency-based studies. Research limitations/implications Breaking the boundaries between two currently remote research disciplines, on the one hand, might dismantle “would-be” innovations in one of these disciplines, and, on the other hand, may provide a fertile soil for mutual transfer of knowledge. A limitation of the authors’ review of PSPM research is that it may insufficiently cover research published in the public sector accounting journals, which could be an outlet for MC-inspired PSPM research. Originality/value The paper unravels the “apparent” and “real” differences between MC and PSPM research, and, in doing so, takes the detected “real” differences as a starting point for discussing in what ways PSPM research can benefit from MC achievements.

Narcissists are assumed to lack the motivation and ability to share and understand the mental states of others. Prior empirical research, however, has yielded inconclusive findings and has differed with respect to the specific aspects of narcissism and socioemotional cognition that have been examined. Here, we propose a differentiated facet approach that can be applied across research traditions and that distinguishes between facets of narcissism (agentic vs. antagonistic) on the one hand, and facets of socioemotional cognition ability (SECA; self-perceived vs. actual) on the other. Using five nonclinical samples in two studies (total N = 602), we investigated the effect of facets of grandiose narcissism on aspects of socioemotional cognition across measures of affective and cognitive empathy, Theory of Mind, and emotional intelligence, while also controlling for general reasoning ability. Across both studies, agentic facets of narcissism were found to be positively related to perceived SECA, whereas antagonistic facets of narcissism were found to be negatively related to perceived SECA. However, both narcissism facets were negatively related to actual SECA. Exploratory condition-based regression analyses further showed that agentic narcissists had a higher directed discrepancy between perceived and actual SECA: They self-enhanced their socio-emotional capacities. Implications of these results for the multifaceted theoretical understanding of the narcissism-SECA link are discussed.

The removal, redistribution, and transient storage of sediments in tectonically active mountain belts is thought to exert a first-order control on shallow crustal stresses, fault activity, and hence on the spatiotemporal pattern of regional deformation processes. Accordingly, sediment loading and unloading cycles in intermontane sedimentary basins may inhibit or promote intrabasinal faulting, respectively, but unambiguous evidence for this potential link has been elusive so far. Here we combine 2D numerical experiments that simulate contractional deformation in a broken-foreland setting (i.e., a foreland where shortening is diachronously absorbed by spatially disparate, reverse faults uplifting basement blocks) with field data from intermontane basins in the NW Argentine Andes. Our modeling results suggest that thicker sedimentary fills (>0.7-1.0 km) may suppress basinal faulting processes, while thinner fills (<0.7 km) tend to delay faulting. Conversely, the removal of sedimentary loads via fluvial incision and basin excavation promotes renewed intrabasinal faulting. These results help to better understand the tectono-sedimentary history of intermontane basins that straddle the eastern border of the Andean Plateau in northwestern Argentina. For example, the Santa Maria and the Humahuaca basins record intrabasinal deformation during or after sediment unloading, while the Quebrada del Toro Basin reflects the suppression of intrabasinal faulting due to loading by coarse conglomerates. We conclude that sedimentary loading and unloading cycles may exert a fundamental control on spatiotemporal deformation patterns in intermontane basins of tectonically active broken forelands. (C) 2018 Elsevier B.V. All rights reserved.

During development in human erythrocytes, the malaria parasite Plasmodium falciparum internalizes a large part of the cellular content of the host cell. The internalized cytosol, consisting largely of hemoglobin, is transported to the parasite’s food vacuole where it is degraded, providing nutrients and space for growth. This host cell cytosol uptake (HCCU) is crucial for parasite survival but the parasite proteins mediating this process remain obscure. Here, we identify P. falciparum VPS45 as an essential factor in HCCU. Conditional inactivation of PfVPS45 led to an accumulation of host cell cytosol-filled vesicles within the parasite and inhibited the delivery of hemoglobin to the parasite's digestive vacuole, resulting in arrested parasite growth. A proportion of these HCCU vesicle intermediates was positive for phosphatidylinositol 3-phosphate, suggesting endosomal characteristics. Thus PfVPS45 provides insight into the elusive machinery of the ingestion pathway in a parasite that contains an endolysosomal system heavily repurposed for protein secretion.

The blazar Mrk 501 (z = 0.034) was observed at very-high-energy (VHE, E greater than or similar to 100 GeV) gamma-ray wavelengths during a bright flare on the night of 2014 June 23-24 (MJD 56832) with the H.E.S.S. phase-II array of Cherenkov telescopes. Data taken that night by H.E.S.S. at large zenith angle reveal an exceptional number of gamma-ray photons at multi-TeV energies, with rapid flux variability and an energy coverage extending significantly up to 20 TeV. This data set is used to constrain Lorentz invariance violation (LIV) using two independent channels: a temporal approach considers the possibility of an energy dependence in the arrival time of gamma-rays, whereas a spectral approach considers the possibility of modifications to the interaction of VHE gamma-rays with extragalactic background light (EBL) photons. The non-detection of energy-dependent time delays and the non-observation of deviations between the measured spectrum and that of a supposed power-law intrinsic spectrum with standard EBL attenuation are used independently to derive strong constraints on the energy scale of LIV (E-QG) in the subluminal scenario for linear and quadratic perturbations in the dispersion relation of photons. For the case of linear perturbations, the 95% confidence level limits obtained are E-QG,E-1 > 3.6 x 10(17) GeV using the temporal approach and E-QG,E-1 > 2.6 x 10(19) GeV using the spectral approach. For the case of quadratic perturbations, the limits obtained are E-QG,E-2 > 8.5 x 10(10) GeV using the temporal approach and E-QG,E-2 > 7.8 x 10(11) GeV using the spectral approach.

We studied the effect of three major forest management types (unmanaged beech, selection beech, and age class forests) and stand variables (SMId, soil pH, proportion of conifers, litter cover, deadwood cover, rock cover and cumulative cover of woody trees and shrubs) on bryophyte species richness in 1050 forest plots in three regions in Germany. In addition, we analysed the species richness of four ecological guilds of bryophytes according to their colonized substrates (deadwood, rock, soil, bark) and the number of woodland indicator bryophyte species. Beech selection forests turned out to be the most species rich management type, whereas unmanaged beech forests revealed even lower species numbers than age-class forests. Increasing conifer proportion increased bryophyte species richness but not the number of woodland indicator bryophyte species. The richness of the four ecological guilds mainly responded to the abundance of their respective substrate. We conclude that the permanent availability of suitable substrates is most important for bryophyte species richness in forests, which is not stringently linked to management type. Therefore, managed age-class forests and selection forests may even exceed unmanaged forests in bryophyte species richness due to higher substrate supply and therefore represent important habitats for bryophytes. Typical woodland indicator bryophytes and their species richness were negatively affected by SMId (management intensity) and therefore better indicate forest integrity than the species richness of all bryophytes. Nature conservation efforts should focus on the reduction of management intensity. Moreover, maintaining and increasing a variability of substrates and habitats, such as coarse woody debris, increasing structural heterogeneity by retaining patches with groups of old, mature to over-mature trees in managed forests, maintaining forest climate conditions by silvicultural methods that assure stand continuity, e.g. by selection cutting rather than clear cutting and shelterwood logging might promote bryophyte diversity and in particular the one of woodland indicator bryophytes.

Wolf-Rayet stars of the carbon sequence (WC stars) are an important cornerstone in the late evolution of massive stars before their core collapse. As core-helium burning, hydrogen-free objects with huge mass-loss, they are likely the last observable stage before collapse and thus promising progenitor candidates for type Ib/c supernovae. Their strong mass-loss furthermore provides challenges and constraints to the theory of radiatively driven winds. Thus, the determination of the WC star parameters is of major importance for several astrophysical fields. With Gaia DR2, for the first time parallaxes for a large sample of Galactic WC stars are available, removing major uncertainties inherent to earlier studies. In this work, we re-examine a previously studied sample of WC stars to derive key properties of the Galactic WC population. All quantities depending on the distance are updated, while the underlying spectral analyzes remain untouched. Contrasting earlier assumptions, our study yields that WC stars of the same subtype can significantly vary in absolute magnitude. With Gaia DR2, the picture of the Galactic WC population becomes more complex: We obtain luminosities ranging from log L/L-circle dot = 4.9-6.0 with one outlier (WR 119) having log L/L-circle dot = 4.7. This indicates that the WC stars are likely formed from a broader initial mass range than previously assumed. We obtain mass-loss rates ranging between log(M) over dot = -5.1 and -4.1, with (M) over dot proportional to L-0.68 and a linear scaling of the modified wind momentum with luminosity. We discuss the implications for stellar evolution, including unsolved issues regarding the need of envelope inflation to address the WR radius problem, and the open questions in regard to the connection of WR stars with Gamma-ray bursts. WC and WO stars are progenitors of massive black holes, collapsing either silently or in a supernova that most-likely has to be preceded by a WO stage.

Context. We present a detailed view of the pulsar wind nebula (PWN) HESS J1825-137. We aim to constrain the mechanisms dominating the particle transport within the nebula, accounting for its anomalously large size and spectral characteristics. Aims. The nebula was studied using a deep exposure from over 12 years of H.E.S.S. I operation, together with data from H.E.S.S. II that improve the low-energy sensitivity. Enhanced energy-dependent morphological and spatially resolved spectral analyses probe the very high energy (VHE, E > 0.1 TeV) gamma-ray properties of the nebula. Methods. The nebula emission is revealed to extend out to 1.5 degrees from the pulsar, similar to 1.5 times farther than previously seen, making HESS J1825-137, with an intrinsic diameter of similar to 100 pc, potentially the largest gamma-ray PWN currently known. Characterising the strongly energy-dependent morphology of the nebula enables us to constrain the particle transport mechanisms. A dependence of the nebula extent with energy of R proportional to E alpha with alpha = -0.29 +/- 0.04(stat) +/- 0.05(sys) disfavours a pure diffusion scenario for particle transport within the nebula. The total gamma-ray flux of the nebula above 1 TeV is found to be (1.12 +/- 0.03(stat) +/- 0.25(sys)) +/- 10(-11) cm(-2) s(-1), corresponding to similar to 64% of the flux of the Crab nebula. Results. HESS J1825-137 is a PWN with clearly energy-dependent morphology at VHE gamma-ray energies. This source is used as a laboratory to investigate particle transport within intermediate-age PWNe. Based on deep observations of this highly spatially extended PWN, we produce a spectral map of the region that provides insights into the spectral variation within the nebula.

Groundwater travel time distributions (TTDs) provide a robust description of the subsurface mixing behavior and hydrological response of a subsurface system. Lagrangian particle tracking is often used to derive the groundwater TTDs. The reliability of this approach is subjected to the uncertainty of external forcings, internal hydraulic properties, and the interplay between them. Here, we evaluate the uncertainty of catchment groundwater TTDs in an agricultural catchment using a 3-D groundwater model with an overall focus on revealing the relationship between external forcing, internal hydraulic properties, and TTD predictions. Eight recharge realizations are sampled from a high-resolution dataset of land surface fluxes and states. Calibration-constrained hydraulic conductivity fields (Ks fields) are stochastically generated using the null-space Monte Carlo (NSMC) method for each recharge realization. The random walk particle tracking (RWPT) method is used to track the pathways of particles and compute travel times. Moreover, an analytical model under the random sampling (RS) assumption is fit against the numerical solutions, serving as a reference for the mixing behavior of the model domain. The StorAge Selection (SAS) function is used to interpret the results in terms of quantifying the systematic preference for discharging young/old water. The simulation results reveal the primary effect of recharge on the predicted mean travel time (MTT). The different realizations of calibration-constrained Ks fields moderately magnify or attenuate the predicted MTTs. The analytical model does not properly replicate the numerical solution, and it underestimates the mean travel time. Simulated SAS functions indicate an overall preference for young water for all realizations. The spatial pattern of recharge controls the shape and breadth of simulated TTDs and SAS functions by changing the spatial distribution of particles' pathways. In conclusion, overlooking the spatial nonuniformity and uncertainty of input (forcing) will result in biased travel time predictions. We also highlight the worth of reliable observations in reducing predictive uncertainty and the good interpretability of SAS functions in terms of understanding catchment transport processes.

We have developed a genetic circuit in Escherichia coli that can be used to select for protein-protein interactions of different strengths by changing antibiotic concentrations in the media. The genetic circuit links protein-protein interaction strength to beta-lactamase activity while simultaneously imposing tuneable positive and negative selection pressure for beta-lactamase activity. Cells only survive if they express interacting proteins with affinities that fall within set high- and low-pass thresholds; i.e. the circuit therefore acts as a bandpass filter for protein-protein interactions. We show that the circuit can be used to recover protein-protein interactions of desired affinity from a mixed population with a range of affinities. The circuit can also be used to select for inhibitors of protein-protein interactions of defined strength. (C) 2018 Elsevier Ltd. All rights reserved.

Many solar wind observations at 1 au indicate that the proton (as well as electron) temperature anisotropy is limited. The data distribution in the (A(a), beta(a),(parallel to))-plane have a rhombic-shaped form around beta(a),(parallel to) similar to 1. The boundaries of the temperature anisotropy at beta(a),(parallel to) > 1 can be well explained by the threshold conditions of the mirror (whistler) and oblique proton (electron) firehose instabilities in a bi-Maxwellian plasma, whereas the physical mechanism of the similar restriction at beta(a),(parallel to) < 1 is still under debate. One possible option is Coulomb collisions, which we revisit in the current work. We derive the relaxation rate nu(A)(aa) of the temperature anisotropy in a bi-Maxwellian plasma that we then study analytically and by observed proton data from WIND. We found that nu(A)(pp) increases toward small beta(p),(parallel to) < 1. We matched the data distribution in the (A(p), beta(p),(parallel to))-plane with the constant contour nu(A)(pp) = 2.8 . 10(-6) s(-1), corresponding to the minimum value for collisions to play a role. This contour fits rather well the left boundary of the rhombic-shaped data distribution in the (A(p), beta(p),(parallel to))-plane. Thus, Coulomb collisions are an interesting candidate for explaining the limitations of the temperature anisotropy in the solar wind with small beta(a),(parallel to) < 1 at 1 au.

In her writings on ancient myth, the British author Natalie Haynes moves women to the centre of attention. Her two latest books, A Thousand Ships and Pandora’s Jar – a fiction novel and a non-fiction one – approach this topic from two different perspectives. This interview takes stock of Haynes’ motives and methodology as well as of the challenges she faces in the process of writing.

Linking deep seismic profiles with regional-scale gravity inversion is a powerful tool to deduce the architecture of rifted margins and their structural evolution. Here we map upper and lower crustal thicknesses of the northern South China Sea (SCS) margin in order to investigate the occurrence of depth-dependent crustal extension from the proximal to the distal margin. By comparing upper and lower crustal stretching factors, we find that the northern margin of the SCS is segmented in three parts: (1) sedimentary basins where upper crust is stretched more than lower crust, (2) distal margin where lower crust is stretched more than upper crust, (3) mostly proximal margin regions where the two layers have similar stretching factors. Our results suggest that sedimentary basins and distal margin prominently feature depth-dependent extension, however accommodated by different processes. While differential thinning within sedimentary basins appears to be governed by lateral pressure variations inducing lower crustal flow, we suggest the distal margin to be affected by a combination of mantle flow-induced lower crustal shearing and sequential fault activity during crustal hyper-extension.

Empirical time series of interacting entities, e.g., species abundances, are highly useful to study ecological mechanisms. Mathematical models are valuable tools to further elucidate those mechanisms and underlying processes. However, obtaining an agreement between model predictions and experimental observations remains a demanding task. As models always abstract from reality one parameter often summarizes several properties. Parameter measurements are performed in additional experiments independent of the ones delivering the time series. Transferring these parameter values to different settings may result in incorrect parametrizations. On top of that, the properties of organisms and thus the respective parameter values may vary considerably. These issues limit the use of a priori model parametrizations. In this study, we present a method suited for a direct estimation of model parameters and their variability from experimental time series data. We combine numerical simulations of a continuous-time dynamical population model with Bayesian inference, using a hierarchical framework that allows for variability of individual parameters. The method is applied to a comprehensive set of time series from a laboratory predator-prey system that features both steady states and cyclic population dynamics. Our model predictions are able to reproduce both steady states and cyclic dynamics of the data. Additionally to the direct estimates of the parameter values, the Bayesian approach also provides their uncertainties. We found that fitting cyclic population dynamics, which contain more information on the process rates than steady states, yields more precise parameter estimates. We detected significant variability among parameters of different time series and identified the variation in the maximum growth rate of the prey as a source for the transition from steady states to cyclic dynamics. By lending more flexibility to the model, our approach facilitates parametrizations and shows more easily which patterns in time series can be explained also by simple models. Applying Bayesian inference and dynamical population models in conjunction may help to quantify the profound variability in organismal properties in nature.

Hantavirus assembly and budding are governed by the surface glycoproteins Gn and Gc. In this study, we investigated the glycoproteins of Puumala, the most abundant Hantavirus species in Europe, using fluorescently labeled wild-type constructs and cytoplasmic tail (CT) mutants. We analyzed their intracellular distribution, co-localization and oligomerization, applying comprehensive live, single-cell fluorescence techniques, including confocal microscopy, imaging flow cytometry, anisotropy imaging and Number&Brightness analysis. We demonstrate that Gc is significantly enriched in the Golgi apparatus in absence of other viral components, while Gn is mainly restricted to the endoplasmic reticulum (ER). Importantly, upon co-expression both glycoproteins were found in the Golgi apparatus. Furthermore, we show that an intact CT of Gc is necessary for efficient Golgi localization, while the CT of Gn influences protein stability. Finally, we found that Gn assembles into higher-order homo-oligomers, mainly dimers and tetramers, in the ER while Gc was present as mixture of monomers and dimers within the Golgi apparatus. Our findings suggest that PUUV Gc is the driving factor of the targeting of Gc and Gn to the Golgi region, while Gn possesses a significantly stronger self-association potential.

The first Hollywood film adaptation of Alexander the Great is Robert Rossen’s 1956 movie. Classicists have primarily been concerned with errors of historicity, Alexander’s assumed tragic traits, and rather associative conclusions concerning the movie’s political implications. This paper raises the question of Rossen’s depiction of Alexander's motives and aims. His assessment of the king is surprisingly complicated. Therefore, for the first time, Rossen's interview comments on Alexander are analysed comprehensively and systematically. Furthermore, it is shown that neglected sources are central to the plot. Finally, the film is interpreted against the backdrop of Rossen’s oeuvre. It can be demonstrated that Rossen’s issue is the problem of ideology. He seeks a redefinition of glory. Military success is only an excuse for the pursuit of mere power. For Rossen, however, the true fame is nothing but the benefit of the people. It took a long time for Alexander to realize that his rule was inane, and to reshape his policy. This interpretation is due to fundamental convictions reflected in Rossen’s oeuvre as well as to his personal experiences in politics. It is a plea for de-ideologization in times of the Cold War.

For the layered transition metal dichalcogenide 1T-TaS2, we establish through a unique experimental approach and density functional theory, how ultrafast charge transfer in 1T-TaS2 takes on isotropic three-dimensional character or anisotropic two-dimensional character, depending on the commensurability of the charge density wave phases of 1T-TaS2. The X-ray spectroscopic core-hole-clock method prepares selectively in-and out-of-plane polarized sulfur 3p orbital occupation with respect to the 1T-TaS2 planes and monitors sub-femtosecond wave packet delocalization. Despite being a prototypical two-dimensional material, isotropic three-dimensional charge transfer is found in the commensurate charge density wave phase (CCDW), indicating strong coupling between layers. In contrast, anisotropic two-dimensional charge transfer occurs for the nearly commensurate phase (NCDW). In direct comparison, theory shows that interlayer interaction in the CCDW phase - not layer stacking variations - causes isotropic three-dimensional charge transfer. This is presumably a general mechanism for phase transitions and tailored properties of dichalcogenides with charge density waves.

A rapidly increasing number of systems is identified in which the stochastic motion of tracer particles follows the Brownian law < r(2)(t)> similar or equal to Dt yet the distribution of particle displacements is strongly non-Gaussian. A central approach to describe this effect is the diffusing diffusivity (DD) model in which the diffusion coefficient itself is a stochastic quantity, mimicking heterogeneities of the environment encountered by the tracer particle on its path. We here quantify in terms of analytical and numerical approaches the first passage behaviour of the DD model. We observe significant modifications compared to Brownian-Gaussian diffusion, in particular that the DD model may have a faster first passage dynamics. Moreover we find a universal crossover point of the survival probability independent of the initial condition.

Radiation therapy is a basic part of cancer treatment. To increase the DNA damage in carcinogenic cells and preserve healthy tissue at the same time, radiosensitizing molecules such as halogenated nucleobase analogs can be incorporated into the DNA during the cell reproduction cycle. In the present study 8.44 eV photon irradiation induced single strand breaks (SSB) in DNA sequences modified with the radiosensitizer 5-bromouracil (U-5Br) and 8-bromoadenine ((8Br)A) are investigated. U-5Br was incorporated in the 13mer oligonucleotide flanked by different nucleobases. It was demonstrated that the highest SSB cross sections were reached, when cytosine and thymine were adjacent to U-5Br, whereas guanine as a neighboring nucleobase decreases the activity of U-5Br indicating that competing reaction mechanisms are active. This was further investigated with respect to the distance of guanine to U-5Br separated by an increasing number of adenine nucleotides. It was observed that the SSB cross sections were decreasing with an increasing number of adenine spacers between guanine and U-5Br until the SSB cross sections almost reached the level of a non-modified DNA sequence, which demonstrates the high sequence dependence of the sensitizing effect of U-5Br. (8Br)A was incorporated in a 13mer oligonucleotide as well and the strand breaks were quantified upon 8.44 eV photon irradiation in direct comparison to a non-modified DNA sequence of the same composition. No clear enhancement of the SSB yield of the modified in comparison to the non-modified DNA sequence could be observed. Additionally, secondary electrons with a maximum energy of 3.6 eV were generated when using Si as a substrate giving rise to further DNA damage. A clear enhancement in the SSB yield can be ascertained, but to the same degree for both the non-modified DNA sequence and the DNA sequence modified with (8Br)A.

Arctic lowlands are characterized by large numbers of small waterbodies, which are known to affect surface energy budgets and the global carbon cycle. Statistical analysis of their size distributions has been hindered by the shortage of observations at sufficiently high spatial resolutions. This situation has now changed with the high-resolution (<5 m) circum-Arctic Permafrost Region Pond and Lake (PeRL) database recently becoming available. We have used this database to make the first consistent, high-resolution estimation of Arctic waterbody size distributions, with surface areas ranging from 0.0001 km(2) (100 m(2)) to 1 km(2). We found that the size distributions varied greatly across the thirty study regions investigated and that there was no single universal size distribution function (including power-law distribution functions) appropriate across all of the study regions. We did, however, find close relationships between the statistical moments (mean, variance, and skewness) of the waterbody size distributions from different study regions. Specifically, we found that the spatial variance increased linearly with mean waterbody size (R-2 = 0.97, p < 2.2e-16) and that the skewness decreased approximately hyperbolically. We have demonstrated that these relationships (1) hold across the 30 Arctic study regions covering a variety of (bio)climatic and permafrost zones, (2) hold over time in two of these study regions for which multi-decadal satellite imagery is available, and (3) can be reproduced by simulating rising water levels in a high-resolution digital elevation model. The consistent spatial and temporal relationships between the statistical moments of the waterbody size distributions underscore the dominance of topographic controls in lowland permafrost areas. These results provide motivation for further analyses of the factors involved in waterbody development and spatial distribution and for investigations into the possibility of using statistical moments to predict future hydrologic dynamics in the Arctic.

The particle-in-cell (PIC) method was developed to investigate microscopic phenomena, and with the advances in computing power, newly developed codes have been used for several fields, such as astrophysical, magnetospheric, and solar plasmas. PIC applications have grown extensively, with large computing powers available on supercomputers such as Pleiades and Blue Waters in the US. For astrophysical plasma research, PIC methods have been utilized for several topics, such as reconnection, pulsar dynamics, non-relativistic shocks, relativistic shocks, and relativistic jets. PIC simulations of relativistic jets have been reviewed with emphasis placed on the physics involved in the simulations. This review summarizes PIC simulations, starting with the Weibel instability in slab models of jets, and then focuses on global jet evolution in helical magnetic field geometry. In particular, we address kinetic Kelvin-Helmholtz instabilities and mushroom instabilities.

A molecular dynamics study was done to reveal the adsorption properties of sodium dioctyl sulfosuccinate (AOT) bilayers on gold Au(111) surfaces. Examining the rotational mobility of AOT molecules, we track that the correlation time of AOT molecules on the adsorbed layer is much higher. The data estimating the diffusive motion of AOT molecule show a substantially lower rate of diffusion (similar to 10(-10) cm(2)/s) in the adsorbed layers in comparison to other ones. The results show that an adsorbed layer is more rigid, whereas the outer layers undergo considerable lateral and vertical fluctuations.

We study the extremal properties of a stochastic process xt defined by the Langevin equation ẋₜ =√2Dₜ ξₜ, in which ξt is a Gaussian white noise with zero mean and Dₜ is a stochastic‘diffusivity’, defined as a functional of independent Brownian motion Bₜ.We focus on threechoices for the random diffusivity Dₜ: cut-off Brownian motion, Dₜt ∼ Θ(Bₜ), where Θ(x) is the Heaviside step function; geometric Brownian motion, Dₜ ∼ exp(−Bₜ); and a superdiffusive process based on squared Brownian motion, Dₜ ∼ B²ₜ. For these cases we derive exact expressions for the probability density functions of the maximal positive displacement and of the range of the process xₜ on the time interval ₜ ∈ (0, T).We discuss the asymptotic behaviours of the associated probability density functions, compare these against the behaviour of the corresponding properties of standard Brownian motion with constant diffusivity (Dₜ = D0) and also analyse the typical behaviour of the probability density functions which is observed for a majority of realisations of the stochastic diffusivity process.

Many European municipalities rely on municipally owned corporations (MOCs) to serve the public interest. Some MOCs, e.g. utilities or hospitals, are also aimed at generating financial revenue, others provide funded services like public transportation. Our article explores local governments’ approaches to the managerial control of influential MOCs. To conceptualize control, we distinguish control mechanisms (e.g. output control), correlates (e.g. policy-profession conflict), and perceived managerial autonomy. Drawing on a sample of 243 MOC top managers in Germany, structural equation modelling reveals four complex relationships between output control, process control, supervisor trust, and policy-profession conflict as antecedents of perceived managerial autonomy.

Work has become more precarious in recent years. Although this claim is more or less uncontested among social scientists, there are a still many questions that have not yet been conclusively answered. What exactly constitutes precariousness? How should it be operationalized and measured? How does the character of precarious employment vary across organizations, occupations, demographic groups, and countries? The edited volume by Arne Kalleberg and Steven Vallas seeks to provide answers to these and related questions. Sociologists from around the world employed different methodologies in a broad range of economic sectors and countries to identify the origins, manifestations, and consequences of precarious work. The different contributions not only illustrate the great heterogeneity that exists within precarious employment but also point to some central features of precarious work independent of the geographical context in which it occurs. Moreover, they highlight some challenges for the study of precarious work. First, drawing on their earlier work, Kalleberg and Vallas conceptualize precarious employment as work that is characterized by uncertainty and insecurity with regard to pay and the stability of the work arrangement; workers in precarious jobs only have limited access to social benefits and statutory protections and bear the entrepreneurial risk of the employment relationship. This broad definition not only captures various forms of nonstandard employment, such as temporary employment, part-time work, or one-person businesses, but also covers informal workers or workers who are at risk of losing their jobs. Nonetheless, this definition does not seem to be broad enough or specific enough to fit the needs of all types of research and to appropriately capture the multifaceted nature of precarious work. Kiersztyn, for example, shows the necessity to distinguish between objective and subjective insecurities when measuring precarious work. Likewise, Rogan et al. point out that the concept of “precarious employment” has little resonance in the developing world, where most of the workforce is at or near poverty and informal work is the default employment type. Second, the book repeatedly illustrates that the increase in precarious work can be attributed to the rise of neoliberal doctrines and practices, the deinstitutionalization of organized workers, and the dismantling of the welfare state. This applies not only to the United States, where market logics have often been equated with economic freedom, but also to countries like Germany with its corporatist tradition and a strong welfare state (Brady and Biegert) as well as to emerging economies like India (Sapkal and Sundar). In the opening chapter, Pulignano, moreover, convincingly argues that the institutional determinants of precariousness should not only be sought at the national level but that the supranational context plays a major role when it comes to explain precarity. Third, by focusing on different aspects of precariousness and employment, the book shows the need for differentiation when studying precarious work. This is nicely illustrated by the following three chapters, which draw different conclusions on the gendered nature of precarious employment. Wallace and Kwak study the rise of “bad jobs” in U.S. metropolitan areas and show that men’s work became more precarious during the Great Financial Crisis. By contrast, Banch and Hanley, who have investigated the prevalence of different forms of nonstandard work since the 1980s in the United States, show that the risk of working in precarious jobs has declined over time for men. Likewise, Witteveen shows that the employment trajectories of young men are less precarious than those of young women in the United States. These seemingly contradictory claims stem from the fact that the authors focused on different aspects of precariousness, used different methodologies and datasets, and took on slightly different populations and time frames. The work on precarious work is hence not yet done. Fourth, precarious work is certainly no longer a characteristic of those with low levels of education but has increasingly become common among professional and technical workers as well. It might come in disguise and is oftentimes perceived as an opportunity, a means for career advancement, and a personal choice. These disguises and perceptions are evident in chapters by Zukin and Papadantonakis on the unpaid work performed by programmers in hackathons, the chapter by Rao on young professionals in international organizations, and to some degree also the chapter by Williams on professional female workers in the oil and gas industry. These insights (and more that are not mentioned here) make the book relevant and interesting to read. A summary chapter to synthesize the diverse findings and potentially also outline some of the methodological challenges in the study of precarious work would have had been a nice close of the book. Furthermore, such a summation would have been the place to speculate about the consequences of recent changes in the world of work, such as the rise of the gig economy and cloud or crowd work, which add new forms of precarity to the ones that we have known thus far. Although it has primarily been written for an academic audience, the book is a highly commendable and enjoyable read for both social scientists and practitioners such as labor activists, human resources managers, and policy makers. Moreover, the book is certainly a valuable teaching resource suitable for graduate and master’s seminars in sociology due to its broad coverage of various aspects of precariousness, geographical regions, and methodological approaches.

Melanoma represents a prime example demonstrating the success of targeted therapy in cancer. Nevertheless, it remained a deadly disease until now, and the identification of new, independent strategies as well as the understanding of their molecular mechanisms may help to finally overcome the high mortality. Both indirubins and TNF-related apoptosis-inducing ligand (TRAIL) represent promising candidates. Here, the indirubin derivative DKP-073 is shown to trigger apoptosis in melanoma cells, which is enhanced by the combination with TRAIL and is accompanied by complete loss of cell viability. Addressing the signaling cascade, characteristic molecular steps were identified as caspase-3 activation, downregulation of XIAP, upregulation of p53 and TRAIL receptor 2, loss of mitochondrial membrane potential, and STAT-3 dephosphorylation. The decisive step, however, turned out to be the early production of ROS already at 1 h. This was proven by antioxidant pretreatment, which completely abolished apoptosis induction and loss of cell viability as well as abrogated all signaling effects listed above. Thus, ROS appeared as upstream of all proapoptotic signaling. The data indicate a dominant role of ROS in apoptosis regulation, and the new pathway may expose a possible Achilles heel of melanoma.

The Test of Masticating and Swallowing Solids (TOMASS) is a validated assessment tool measuring the efficiency of solid bolus intake by four quantitative parameters: discrete bites, masticatory cycles, swallows and time to ingest a single cracker. A normative database for adults (20-80+ years) has previously been established. The objective of this study was to investigate the applicability and reliability of the TOMASS in children and adolescents (TOMASS-C) and to establish the normative database for this younger population. We collected data from 638 participants (male: 311, female: 327) in five age groups (4-18 years) with five different but very similar test crackers in four countries. Significant effects of bolus type (cracker), age group and gender on the TOMASS parameters were identified, requiring stratification of the TOMASS-C database by these variables. Intra-rater reliability was excellent (ICC > 0.94) for all parameters; inter-rater reliability was moderate for "number of swallows" (ICC = 0.54), good for "bites" (ICC = 0.78) and "time" (ICC = 0.82), and excellent for "masticatory cycles" (ICC = 0.96). The "Test of Masticating and Swallowing Solids in Children (TOMASS-C)" was identified to be a reliable diagnostic tool for the comprehensive measurement of discrete oral stage components of solid bolus ingestion, standardised by a large normative database that covers age groups from preschoolers to young adults. While differences between gender groups were less pronounced than in the adult population, previous results relating to changes in masticatory and swallowing as a function of age are confirmed by our data.

We report on Cosmic Origin Spectrograph observations of the gamma-ray bright blazar B2 1215+30, collected in 2015 November. These observations allow for the confirmation of the source redshift from the detection of a Lyα emission feature at λ ~ 1374 Å. The emission feature places the source at a redshift of z = 0.1305 ± 0.003, confirming the source's ground-based spectral measurement. The gamma-ray emission of the source is discussed in the context of the source distance, required for the accurate reconstruction of the intrinsic gamma-ray emission taking the absorption by the extragalactic background light into account. The source distance is found to be low enough that the previously reported detection of an exceptional flaring event from B2 1215+30 in 2014 cannot be used to investigate opacity-specific spectral and variability characteristics introduced by possible ultra-high-energy cosmic-ray propagation.

During social interactions, we rapidly judge others’ trustworthiness on basis of their facial characteristics. Face-based trustworthiness judgments may not only affect our current but also our future interactions because we seem to be more inclined to remember untrustworthy than trustworthy faces. Memory formation of salient stimuli like untrustworthy faces may be modulated by the interplay between the autonomic and central nervous system, which can be indexed by changes in vagally mediated heart rate variability (HRV). To test this assumption, we investigated whether differences in HRV would be associated with differences in memory formation of untrustworthy faces in a sample of healthy participants (n = 34, all female). Untrustworthy faces were remembered more accurately than trustworthy faces, albeit only by participants with high and not low HRV. Across participants, increased memory accuracy for untrustworthy faces was associated with increased HRV. We discuss these findings in the context of neurobiological theories regarding the interplay between the autonomic and central nervous system during the regulation of autonomic, emotional and cognitive processes. (PsycInfo Database Record

We summarize the current state of observations of circumplanetary dust populations, including both dilute and dense rings and tori around the giant planets, ejecta clouds engulfing airless moons, and rings around smaller planetary bodies throughout the Solar System. We also discuss the theoretical models that enable these observations to be understood in terms of the sources, sinks and transport of various dust populations. The dynamics and resulting transport of the particles can be quite complex, due to the fact that their motion is influenced by neutral and plasma drag, radiation pressure, and electromagnetic forcesall in addition to gravity. The relative importance of these forces depends on the environment, as well as the makeup and size of the particles. Possible dust sources include the generation of ejecta particles by impacts, active volcanoes and geysers, and the capture of exogenous particles. Possible dust sinks include collisions with moons, rings, or the central planet, erosion due to sublimation and sputtering, even ejection and escape from the circumplanetary environment.

The extent of continental rifts and subduction zones through deep geological time provides insights into the mechanisms behind supercontinent cycles and the long term evolution of the mantle. However, previous compilations have stopped short of mapping the locations of rifts and subduction zones continuously since the Neoproterozoic and within a self-consistent plate kinematic framework. Using recently published plate models with continuously closing boundaries for the Neoproterozoic and Phanerozoic, we estimate how rift and peri-continental subduction length vary from 1 Ga to present and test hypotheses pertaining to the supercontinent cycle and supercontinent breakup. We extract measures of continental perimeter-to-area ratio as a proxy for the existence of a supercontinent, where during times of supercontinent existence the perimeter-to-area ratio should be low, and during assembly and dispersal it should be high. The amalgamation of Gondwana is clearly represented by changes in the length of peri-continental subduction and the breakup of Rodinia and Pangea by changes in rift lengths. The assembly of Pangea is not clearly defined using plate boundary lengths, likely because its formation resulted from the collision of only two large continents. Instead the assembly of Gondwana (ca. 520 Ma) marks the most prominent change in arc length and perimeter-to-area ratio during the last billion years suggesting that Gondwana during the Early Palaeozoic could explicitly be considered part of a Phanerozoic supercontinent. Consequently, the traditional understanding of the supercontinent cycle, in terms of supercontinent existence for short periods of time before dispersal and re-accretion, may be inadequate to fully describe the cycle. Instead, either a two-stage supercontinent cycle could be a more appropriate concept, or alternatively the time period of 1 to 0 Ga has to be considered as being dominated by supercontinent existence, with brief periods of dispersal and amalgamation.

Quantifying erosion rates, and how they compare to rock uplift rates, is fundamental for understanding landscape response to tectonics and associated sediment fluxes from upland areas. The erosional response to uplift is well-represented by river incision and the associated landslide activity. However, characterising the relationship between these processes remains a major challenge in tectonically active areas, in some cases because landslides can preclude obtaining reliable erosion rates from cosmogenic radionuclide (CRN) concentrations. Here, we quantify the control of tectonics and its coupled geomorphic response on the erosion rates of catchments in southern Italy that are experiencing a transient response to normal faulting. We analyse in-situ Be-10 concentrations for detrital sediment samples, collected along the strike of faults with excellent tectonic constraints and landslide inventories. We demonstrate that Be-10-derived erosion rates are controlled by fault throw rates and the extent of transient incision and associated landsliding in the catchments. We show that the low-relief sub-catchments above knickpoints erode at uniform background rates of similar to 0.10 mm/yr, while downstream of knickpoints, erosion removes similar to 50% of the rock uplifted by the faults, at rates of 0.10-0.64 mm/yr. Despite widespread landsliding, CRN samples provide relatively consistent and accurate erosion rates, most likely because landslides are frequent, small, and shallow, and represent the integrated record of landsliding over several seismic cycles. Consequently, we combine these validated Be-10 erosion rates and data from a geomorphological landslide inventory in a published numerical model, to gain further insight into the long-term landslide rates and sediment mixing, highlighting the potential of CRN data to study landslide dynamics. (C) 2018 Elsevier B.V. All rights reserved.

Objective Plant carnivory is distributed across the tree of life and has evolved at least six times independently, but sequenced and annotated nuclear genomes of carnivorous plants are currently lacking. We have sequenced and structurally annotated the nuclear genome of the carnivorous Roridula gorgonias and that of a non-carnivorous relative, Madeira’s lily-of-the-valley-tree, Clethra arborea, both within the Ericales. This data adds an important resource to study the evolutionary genetics of plant carnivory across angiosperm lineages and also for functional and systematic aspects of plants within the Ericales. Results Our assemblies have total lengths of 284 Mbp (R. gorgonias) and 511 Mbp (C. arborea) and show high BUSCO scores of 84.2% and 89.5%, respectively. We used their predicted genes together with publicly available data from other Ericales’ genomes and transcriptomes to assemble a phylogenomic data set for the inference of a species tree. However, groups of orthologs showed a marked absence of species represented by a transcriptome. We discuss possible reasons and caution against combining predicted genes from genome- and transriptome-based assemblies.