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Association between pubertal stage at first drink and neural reward processing in early adulthood
(2017)
Puberty is a critical time period during human development. It is characterized by high levels of risk-taking behavior, such as increased alcohol consumption, and is accompanied by various neurobiological changes. Recent studies in animals and humans have revealed that the pubertal stage at first drink (PSFD) significantly impacts drinking behavior in adulthood. Moreover, neuronal alterations of the dopaminergic reward system have been associated with alcohol abuse or addiction. This study aimed to clarify the impact of PSFD on neuronal characteristics of reward processing linked to alcohol-related problems. One hundred sixty-eight healthy young adults from a prospective study covering 25 years participated in a monetary incentive delay task measured with simultaneous EEG-fMRI. PSFD was determined according to the age at menarche or Tanner stage of pubertal development, respectively. Alcohol-related problems in early adulthood were assessed with the Alcohol Use Disorder Identification Test (AUDIT). During reward anticipation, decreased fMRI activation of the frontal cortex and increased preparatory EEG activity (contingent negative variation) occurred with pubertal compared to postpubertal first alcohol intake. Moreover, alcohol-related problems during early adulthood were increased in pubertal compared to postpubertal beginners, which was mediated by neuronal activation of the right medial frontal gyrus. At reward delivery, increased fMRI activation of the left caudate and higher feedback-related EEG negativity were detected in pubertal compared to postpubertal beginners. Together with animal findings, these results implicate PSFD as a potential modulator of psychopathology, involving altered reward anticipation. Both PSFD timing and reward processing might thus be potential targets for early prevention and intervention.
Arsenolipids are lipid-soluble organoarsenic compounds, mainly occurring in marine organisms, with arsenic-containing hydrocarbons (AsHCs) and arsenic-containing fatty acids (AsFAs) representing two major subgroups. Recently, toxicity studies of several arsenolipids showed a high cytotoxic potential of those arsenolipids in human liver and bladder cells. Furthermore, feeding studies with Drosophila melanogaster indicated an accumulation of arsenolipids in the fruit fly’s brain. In this study, the neurotoxic potential of three AsHCs, two AsFAs and three metabolites (dimethylarsinic acid, thio/oxo-dimethylarsenopropanoic acid) was investigated in comparison to the toxic reference arsenite (iAsIII) in fully differentiated human brain cells (LUHMES cells). Thereby, in the case of AsHCs both the cell number and cell viability were reduced in a low micromolar concentration range comparable to iAsIII, while AsFAs and the applied metabolites were less toxic. Mechanistic studies revealed that AsHCs reduced the mitochondrial membrane potential, whereas neither iAsIII nor AsFAs had an impact. Furthermore, neurotoxic mechanisms were investigated by examining the neuronal network. Here, AsHCs massively disturbed the neuronal network and induced apoptotic effects, while iAsIII and AsFAs showed comparatively lesser effects. Taking into account the substantial in vitro neurotoxic potential of the AsHCs and the fact that they could transfer across the physiological barriers of the brain, a neurotoxic potential in vivo for the AsHCs cannot be excluded and needs to be urgently characterized.
Research suggests a positive link between critical thinking and creativity. However, this relationship has not been measured in an empirical study. This study aims to explore whether critical thinking can serve to enhance creativity and whether creativity positively mediates the relationship between critical thinking and business performance. In this study, we analyse these relationships within the entrepreneurial context of a web-based business start-up simulation. We examined data from 26 teams of three to four senior business students and found partial support for our hypotheses. Critical thinking positively influenced creativity, measured as the total number of unique product designs. Creativity (unique product designs) also positively mediated the link between critical thinking and performance. This effect, however, did not exist when creativity was assessed through advertisement designs. This research contributes to entrepreneurship and innovation management by demonstrating the importance of critical thinking as a basis for creativity and testing this relationship in a business start-up simulation context.
The biosynthesis of the molybdenum cofactor (Moco) is a highly conserved pathway in bacteria, archaea and eukaryotes. The molybdenum atom in Moco-containing enzymes is coordinated to the dithiolene group of a tricyclic pyranopterin monophosphate cofactor. The biosynthesis of Moco can be divided into three conserved steps, with a fourth present only in bacteria and archaea: (1) formation of cyclic pyranopterin monophosphate, (2) formation of molybdopterin (MPT), (3) insertion of molybdenum into MPT to form Mo-MPT, and (4) additional modification of Mo-MPT in bacteria with the attachment of a GMP or CMP nucleotide, forming the dinucleotide variants of Moco. While the proteins involved in the catalytic reaction of each step of Moco biosynthesis are highly conserved among the Phyla, a surprising link to other cellular pathways has been identified by recent discoveries. In particular, the pathways for FeS cluster assembly and thio-modifications of tRNA are connected to Moco biosynthesis by sharing the same protein components. Further, proteins involved in Moco biosynthesis are not only shared with other pathways, but additionally have moonlighting roles. This review gives an overview of Moco biosynthesis in bacteria and humans and highlights the shared function and moonlighting roles of the participating proteins.
Climate change is expected to exacerbate the current threats to freshwater ecosystems, yet multifaceted studies on the potential impacts of climate change on freshwater biodiversity at scales that inform management planning are lacking. The aim of this study was to fill this void through the development of a novel framework for assessing climate change vulnerability tailored to freshwater ecosystems. The three dimensions of climate change vulnerability are as follows: (i) exposure to climate change, (ii) sensitivity to altered environmental conditions and (iii) resilience potential. Our vulnerability framework includes 1685 freshwater species of plants, fishes, molluscs, odonates, amphibians, crayfish and turtles alongside key features within and between catchments, such as topography and connectivity. Several methodologies were used to combine these dimensions across a variety of future climate change models and scenarios. The resulting indices were overlaid to assess the vulnerability of European freshwater ecosystems at the catchment scale (18 783 catchments). The Balkan Lakes Ohrid and Prespa and Mediterranean islands emerge as most vulnerable to climate change. For the 2030s, we showed a consensus among the applied methods whereby up to 573 lake and river catchments are highly vulnerable to climate change. The anthropogenic disruption of hydrological habitat connectivity by dams is the major factor reducing climate change resilience. A gap analysis demonstrated that the current European protected area network covers <25% of the most vulnerable catchments. Practical steps need to be taken to ensure the persistence of freshwater biodiversity under climate change. Priority should be placed on enhancing stakeholder cooperation at the major basin scale towards preventing further degradation of freshwater ecosystems and maintaining connectivity among catchments. The catchments identified as most vulnerable to climate change provide preliminary targets for development of climate change conservation management and mitigation strategies.
Radiocarbon and optically stimulated luminescence dating of sediments from Lake Karakul, Tajikistan
(2017)
Lake Karakul in the eastern Pamirs is a large and closed-basin lake in a partly glaciated catchment. Two parallel sediment cores were collected from 12 m water depth. The cores were correlated using XRF analysis and dated using radiocarbon and OSL techniques. The age results of the two dating methods are generally in agreement. The correlated composite core of 12.26 m length represents continuous accumulation of sediments in the lake basin since 31 ka. The lake reservoir effect (LRE) remained relatively constant over this period. High sediment accumulation rates (SedARs) were recorded before 23 ka and after 6.5 ka. The relatively close position of the coring location near the eastern shore of the lake implies that high SedARs resulted from low lake levels. Thus, high SedARs and lower lake levels before 23 ka probably reflect cold and dry climate conditions that inhibited the arrival of moist air at high elevation in the eastern Pamirs. Low lake levels after 6.5 ka were probably caused by declining temperatures after the warmer early Holocene, which had caused a reduction in water resources stored as snow, ice and frozen ground in the catchment. Low SedARs during 23-6.5 ka suggest increased lake levels in Lake Karakul. A short-lived increase of SedARs at 15 ka probably corresponds to the rapid melting of glaciers in the Karakul catchment during the Greenland Interstadial le, shortly after glaciers in the catchment had reached their maximum extents. The sediment cores from Lake Karakul represent an important climate archive with robust chronology for the last glacial interglacial cycle from Central Asia. (C) 2017 Elsevier B.V. All rights reserved.
The oomycete Plasmopara obducens was first described on wild Impatiens noli-tangere in Germany in 1877. About 125 years later the first occurrence of P. obducens on cultivated I. walleriana in the United Kingdom was reported, and a worldwide epidemic followed. Although this pathogen is a major threat for ornamental busy lizzy, the identity of the pathogen remained unconfirmed and the high host specificity observed for the genus Plasmopara cast doubts regarding its determination as P. obducens. In this study, using multigene phylogenies and morphological investigation, it is revealed that P. obducens on I. noli-tangere is not the conspecific with the pathogen affecting I. walleriana and another ornamental balsam, I. balsamina. As a consequence, the new names P. destructor and P. velutina are introduced for the pathogens of I. walleriana and I. balsamina, respectively.
Low-relief plateaus separated by deeply incised fjords are hallmarks of glaciated, passive continental margins. Spectacular examples fringe the once ice-covered North Atlantic coasts of Greenland, Norway and Canada, but low-relief plateau landscapes also underlie present-day ice sheets in Antarctica and Greenland. Dissected plateaus have long been viewed as the outcome of selective linear erosion by ice sheets that focus incision in glacial troughs, leaving the intervening landscapes essentially unaffected. According to this hypothesis, the plateaus are remnants of preglacial low-relief topography. However, here we use computational experiments to show that, like fjords, plateaus are emergent properties of long-term ice-sheet erosion. Ice sheets can either increase or decrease subglacial relief depending on the wavelength of the underlying topography, and plateau topography arises dynamically from evolving feedbacks between topography, ice dynamics and erosion over million-year timescales. This new mechanistic explanation for plateau formation opens the possibility of plateaus contributing significantly to accelerated sediment flux at the onset of the late Cenozoic glaciations, before becoming stable later in the Quaternary.
Canonical finger postures, as used in counting, activate number knowledge, but the exact mechanism for this priming effect is unclear. Here we dissociated effects of visual versus motor priming of number concepts. In Experiment 1, participants were exposed either to pictures of canonical finger postures (visual priming) or actively produced the same finger postures (motor priming) and then used foot responses to rapidly classify auditory numbers (targets) as smaller or larger than 5. Classification times revealed that manually adopted but not visually perceived postures primed magnitude classifications. Experiment 2 obtained motor priming of number processing through finger postures also with vocal responses. Priming only occurred through canonical and not through non-canonical finger postures. Together, these results provide clear evidence for motor priming of number knowledge. Relative contributions of vision and action for embodied numerical cognition and the importance of canonicity of postures are discussed.
Low-frequency fluctuations are pervasively observed in the solar wind. The present paper theoretically calculates the steady state spectra of low-frequency electromagnetic (EM) fluctuations of the Alfvenic type for thermal equilibrium plasma. The analysis is based upon a recently formulated theory of spontaneously emitted EM fluctuations in magnetized thermal plasmas. It is found that the fluctuations in the magnetosonic mode branch is constant, while the kinetic Alfvenic mode spectrum is dependent on a form factor that is a function of perpendicular wave number. Potential applicability of the present work in the wider context of heliospheric research is also discussed.
Large-scale commercial cropping of soybeans expanded in the tropical Amazon and Cerrado biomes of Brazil after 1990. More recently, cropping intensified from single-cropping of soybeans to double-cropping of soybeans with corn or cotton. Cropland expansion and intensification, and the accompanying use of mineral fertilizers, raise concerns about whether nutrient runoff and impacts to surface waters will be similar to those experienced in commercial cropland regions at temperate latitudes. We quantified water infiltration through soils, water yield, and streamwater chemistry in watersheds draining native tropical forest and single-and double-cropped areas on the level, deep, highly weathered soils where cropland expansion and intensification typically occurs. Although water yield increased four-fold from croplands, streamwater chemistry remained largely unchanged. Soil characteristics exerted important control over the movement of nitrogen (N) and phosphorus (P) into streams. High soil infiltration rates prevented surface erosion and movement of particulate P, while P fixation in surface soils restricted P movement to deeper soil layers. Nitrogen retention in deep soils, likely by anion exchange, also appeared to limit N leaching and export in streamwater from both single-and double-cropped watersheds that received nitrogen fertilizer. These mechanisms led to lower streamwater P and N concentrations and lower watershed N and P export than would be expected, based on studies from temperate croplands with similar cropping and fertilizer application practices.
The trafficking and delivery of sulfur to cofactors and nucleosides is a highly regulated and conserved process among all organisms. All sulfur transfer pathways generally have an L-cysteine desulfurase as an initial sulfur mobilizing enzyme in common, which serves as a sulfur donor for the biosynthesis of sulfur-containing biomolecules like iron sulfur (Fe-S) clusters, thiamine, biotin, lipoic acid, the molybdenum cofactor (Moco), and thiolated nucleosides in tRNA. The human L-cysteine desulfurase NFS1 and the Escherichia coli homologue IscS share a level of amino acid sequence identity of similar to 60%. While E. coli IscS has a versatile role in the cell and was shown to have numerous interaction partners, NFS1 is mainly localized in mitochondria with a crucial role in the biosynthesis of Fe-S clusters. Additionally, NFS1 is also located in smaller amounts in the cytosol with a role in Moco biosynthesis and mcm(5)s(2)U34 thio modifications of nucleosides in tRNA. NFS1 and IscS were conclusively shown to have different interaction partners in their respective organisms. Here, we used functional complementation studies of an E. coli iscS deletion strain with human NFS1 to dissect their conserved roles in the transfer of sulfur to a specific target protein. Our results show that human NFS1 and E. coli IscS share conserved binding sites for proteins involved in Fe-S cluster assembly like IscU, but not with proteins for tRNA thio modifications or Moco biosynthesis. In addition, we show that human NFS1 was almost fully able to complement the role of IscS in Moco biosynthesis when its specific interaction partner protein MOCS3 from humans was also present.
Preceramic human skeletal remains preserved in submerged caves near Tulum in the Mexican state of Quintana Roo, Mexico, reveal conflicting results regarding C-14 dating. Here we use U-series techniques for dating a stalagmite overgrowing the pelvis of a human skeleton discovered in the submerged Chan Hol cave. The oldest closed system U/Th age comes from around 21 mm above the pelvis defining the terminus ante quem for the pelvis to 11311 +/- 370 y BP. However, the skeleton might be considerable older, probably as old as 13 ky BP as indicated by the speleothem stable isotope data. The Chan Hol individual confirms a late Pleistocene settling of Mesoamerica and represents one of the oldest human osteological remains in America.
In nature, proteins self-assemble into various structures with different dimensions. To construct these nanostructures in laboratories, normally proteins with different symmetries are selected. However, most of these approaches are engineering-intensive and highly dependent on the accuracy of the protein design. Herein, we report that a simple native protein LecA assembles into one-dimensional nanoribbons and nanowires, two-dimensional nanosheets, and three-dimensional layered structures controlled mainly by small-molecule assembly-inducing ligands RnG (n = 1, 2, 3, 4, 5) with varying numbers of ethylene oxide repeating units. To understand the formation mechanism of the different morphologies controlled by the small-molecule structure, molecular simulations were performed from microscopic and mesoscopic view, which presented a clear relationship between the molecular structure of the ligands and the assembled patterns. These results introduce an easy strategy to control the assembly structure and dimension, which could shed light on controlled protein assembly.
What are the features of partitioning of crystalline materials on the surface of a two-component icosahedral vesicle? We model the response of the rigid hardly stretchable crystalline icosahedra upon addition of a softer component on its surface. We demonstrate how the soft phase "invades" the shell regions with the highest elastic energy density around 12 5-fold topological defects. We explore the phase diagram of these inhomogeneous shells as a function of the soft material fraction, shell radius, and elastic moduli of the two phases. The findings are compared with the recent computer simulation findings, and their biological relevance, for example, for the structure of icosahedral viruses, is also discussed.
Perception of facial expressions reveals selective affect-biased attention in humans and orangutans
(2017)
It is widely accepted that modern pigs were domesticated independently at least twice, and Chinese native pigs are deemed as direct descendants of the first domesticated pigs in the corresponding domestication centers. By analyzing mitochondrial DNA sequences of an extensive sample set spanning 10,000 years, we find that the earliest pigs from the middle Yellow River region already carried the maternal lineages that are dominant in both younger archaeological populations and modern Chinese pigs. Our data set also supports early Neolithic pig utilization and a long-term in situ origin for northeastern Chinese pigs during 8,000-3,500 BP, suggesting a possibly independent domestication in northeast China. Additionally, we observe a genetic replacement in ancient northeast Chinese pigs since 3,500 BP. The results not only provide increasing evidence for pig origin in the middle Yellow River region but also depict an outline for the process of early pig domestication in northeast China.
Intrinsically Disordered Stress Protein COR15A Resides at the Membrane Surface during Dehydration
(2017)
Plants from temperate climate zones are able to increase their freezing tolerance during exposure to low, above zero temperatures in a process termed cold acclimation. During this process, several cold-regulated (COR) proteins are accumulated in the cells. One of them is COR15A, a small, intrinsically disordered protein that contributes to leaf freezing tolerance by stabilizing cellular membranes. The isolated protein folds into amphipathic a-helices in response to increased crowding conditions, such as high concentrations of glycerol. Although there is evidence for direct COR15A-membrane interactions, the orientation and depth of protein insertion were unknown. In addition, although folding due to high osmolyte concentrations had been established, the folding response of the protein under conditions of gradual dehydration had not been investigated. Here we show, using Fourier transform infrared spectroscopy, that COR15A starts to fold into a-helices already under mild dehydration conditions (97% relative humidity (RH), corresponding to freezing at -3 degrees C) and that folding gradually increases with decreasing RH. Neutron diffraction experiments at 97 and 75% RH established that the presence of COR15A had no significant influence on the structure of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membranes. However, using deuterated POPC we. could clearly establish that COR15A interacts with the membranes and penetrates below the headgroup region into the upper part of the fatty acyl chain region. This localization is in agreement with our hypothesis that COR15A-membrane interaction is at least, in part, driven by a hydrophobic interaction between the lipids and the hydrophobic face of the amphipathic protein alpha-helix.
Magnetosome Organization in Magnetotactic Bacteria Unraveled by Ferromagnetic Resonance Spectroscopy
(2017)
Magnetotactic bacteria form assemblies of magnetic nanoparticles called magnetosomes. These magnetosomes are typically arranged in chains, but other forms of assemblies such as clusters can be observed in some species and genetic mutants. As such, the bacteria have developed as a model for the understanding of how organization of particles can influence the magnetic properties. Here, we use ferromagnetic resonance spectroscopy to measure the magnetic anisotropies in different strains of Magnetosprillum gtyphiswaldense MSR-1, a bacterial species that is amendable to genetic mutations. We combine our experimental results with a model describing the spectra. The model includes chain imperfections and misalignments following a Fisher distribution function, in addition to the intrinsic magnetic properties of the magnetosomes. Therefore, by applying the model to analyze the ferromagnetic resonance data, the distribution of orientations in the bulk sample can be retrieved in addition to the average magnetosome arrangement. In this way, we quantitatively characterize the magnetosome arrangement in both wild-type cells and Delta mamJ mutants, which exhibit differing magnetosome organization.
Aldehyde oxidases (AOXs) are molybdoflavoenzymes with an important role in the metabolism and detoxification of heterocyclic compounds and aliphatic as well as aromatic aldehydes. The enzymes use oxygen as the terminal electron acceptor and produce reduced oxygen species during turnover. Four different enzymes, mAOX1, mAOX3, mAOX4, and mAOX2, which are the products of distinct genes, are present in the mouse. A direct and simultaneous comparison of the enzymatic properties and characteristics of the four enzymes has never been performed. In this report, the four catalytically active mAOX enzymes were purified after heterologous expression in Escherichia coli. The kinetic parameters of the four mouse AOX enzymes were determined and compared with the use of six predicted substrates of physiologic and toxicological interest, i.e., retinaldehyde, N1-methylnicotinamide, pyridoxal, vanillin, 4-(dimethylamino) cinnamaldehyde (p-DMAC), and salicylaldehyde. While retinaldehyde, vanillin, p-DMAC, and salycilaldehyde are efficient substrates for the four mouse AOX enzymes, N1-methylnicotinamide is not a substrate of mAOX1 or mAOX4, and pyridoxal is notmetabolized by any of the purified enzymes. Overall, mAOX1, mAOX2, mAOX3, and mAOX4 are characterized by significantly different KM and kcat values for the active substrates. The four mouse AOXs are also characterized by quantitative differences in their ability to produce superoxide radicals. With respect to this last point, mAOX2 is the enzyme generating the largest rate of superoxide radicals of around 40% in relation to moles of substrate converted, and mAOX1, the homolog to the human enzyme, produces a rate of approximately 30% of superoxide radicals with the same substrate.
Tailed bacteriophages specific for Gram‐negative bacteria encounter lipopolysaccharide (LPS) during the first infection steps. Yet, it is not well understood how biochemistry of these initial interactions relates to subsequent events that orchestrate phage adsorption and tail rearrangements to initiate cell entry. For many phages, long O‐antigen chains found on the LPS of smooth bacterial strains serve as essential receptor recognized by their tailspike proteins (TSP). Many TSP are depolymerases and O‐antigen cleavage was described as necessary step for subsequent orientation towards a secondary receptor. However, O‐antigen specific host attachment must not always come along with O‐antigen degradation. In this issue of Molecular Microbiology Prokhorov et al. report that coliphage G7C carries a TSP that deacetylates O‐antigen but does not degrade it, whereas rough strains or strains lacking O‐antigen acetylation remain unaffected. Bacteriophage G7C specifically functionalizes its tail by attaching the deacetylase TSP directly to a second TSP that is nonfunctional on the host's O‐antigen. This challenges the view that bacteriophages use their TSP only to clear their way to a secondary receptor. Rather, O‐antigen specific phages may employ enzymatically active TSP as a tool for irreversible LPS membrane binding to initiate subsequent infection steps.
The concept of a Global Monsoon (GM) has been proposed based on modern precipitation observations, but its application over a wide range of temporal scales is still under debate. Here, we present a synthesis of 268 continental paleo-moisture records collected from monsoonal systems in the Eastern Hemisphere, including the East Asian Monsoon (EAsM), the Indian Monsoon (IM), the East African Monsoon (EAfM), and the Australian Monsoon (AuM) covering the last 18,000 years. The overall pattern of late Glacial to Holocene moisture change is consistent with those inferred from ice cores and marine records. With respect to the last 10,000 years (10 ka), i.e. a period that has high spatial coverage, a Fuzzy c-Means clustering analysis of the moisture index records together with "Xie-Beni" index reveals four clusters of our data set. The paleoclimatic meaning of each cluster is interpreted considering the temporal evolution and spatial distribution patterns. The major trend in the tropical AuM, EAfM, and IM regions is a gradual decrease in moisture conditions since the early Holocene. Moisture changes in the EAsM regions show maximum index values between 8 and 6 ka. However, records located in nearby subtropical areas, i.e. in regions not influenced by the intertropical convergence zone, show an opposite trend compared to the tropical monsoon regions (AuM, EAfM and IM), i.e. a gradual increase. Analyses of modern meteorological data reveal the same spatial patterns as in the paleoclimate records such that, in times of overall monsoon strengthening, lower precipitation rates are observed in the nearby subtropical areas. We explain this pattern as the effect of a strong monsoon circulation suppressing air uplift in nearby subtropical areas, and hence hindering precipitation. By analogy to the modern system, this would mean that during the early Holocene strong monsoon period, the intensified ascending airflows within the monsoon domains led to relatively weaker ascending or even descending airflows in the adjacent subtropical regions, resulting in a precipitation deficit compared to the late Holocene. Our conceptual model therefore integrates regionally contrasting moisture changes into the Global Monsoon hypothesis. (C) 2017 Elsevier Ltd. All rights reserved.
This study is intended to find more effective and robust clinical diagnostic indices to characterize muscle strength and coordination alternation following anterior cruciate ligament (ACL) rupture. To evaluate angle-specific moments and hamstring (H)/quadriceps (Q) ratios, 46 male subjects with unilateral chronic ACL-rupture performed isokinetic concentric (c), eccentric (e) quadriceps and hamstring muscle tests respectively at 60 degrees/s. Normalized moments and H/Q ratios were calculated for peak moment (PM) and 30 degrees, 40 degrees, 50 degrees, 60 degrees, 70 degrees, 80 degrees knee flexion angles. Furthermore, we introduced single-to-arithmetic-mean (SAM) and single-to-root-mean-square (SRMS) muscle co-contraction ratios, calculating them for specific angles and different contraction repetitions. Normalized PM and 40 degrees specific concentric quadriceps, concentric hamstring strength in the ACL-deficient knee were reduced significantly (P <= 0.05). Concentric angle-specific moments together with Qe/Qc ratios at 40 degrees (d = 0.766 vs. d = 0.654) identify more obvious differences than peak values in ACL ruptured limbs. Furthermore, we found SRMS-QeQc deficits at 40 degrees showed stronger effect than Qe/Qc ratios (d = 0.918 vs. d = 0.766), albeit other ratio differences remained basically the same effect size as the original H/Q ratios. All the newly defined SAM and SRMS indices could decrease variance. Overall, 40 degrees knee moments and SAM/ SRMS ratios might be new potential diagnosis indices for ACL rupture detection.
As an emerging sub-field of music information retrieval (MIR), music imagery information retrieval (MIIR) aims to retrieve information from brain activity recorded during music cognition-such as listening to or imagining music pieces. This is a highly interdisciplinary endeavor that requires expertise in MIR as well as cognitive neuroscience and psychology. The OpenMIIR initiative strives to foster collaborations between these fields to advance the state of the art in MIIR. As a first step, electroencephalography (EEG) recordings ofmusic perception and imagination have beenmade publicly available, enabling MIR researchers to easily test and adapt their existing approaches for music analysis like fingerprinting, beat tracking or tempo estimation on this new kind of data. This paper reports on first results of MIIR experiments using these OpenMIIR datasets and points out how these findings could drive new research in cognitive neuroscience.
Strand breaks and conformational changes of DNA have consequences for the physiological role of DNA. The natural protecting molecule ectoine is beneficial to entire bacterial cells and biomolecules such as proteins by mitigating detrimental effects of environmental stresses. It was postulated that ectoine-like molecules bind to negatively charged spheres that mimic DNA surfaces. We investigated the effect of ectoine on DNA and whether ectoine is able to protect DNA from damages caused by ultraviolet radiation (UV-A). In order to determine different isoforms of DNA, agarose gel electrophoresis and atomic force microscopy experiments were carried out with plasmid pUC19 DNA. Our quantitative results revealed that a prolonged incubation of DNA with ectoine leads to an increase in transitions from supercoiled (undamaged) to open circular (single-strand break) conformation at pH 6.6. The effect is pH dependent and no significant changes were observed at physiological pH of 7.5. After UV-A irradiation in ectoine solution, changes in DNA conformation were even more pronounced and this effect was pH dependent. We hypothesize that ectoine is attracted to the negatively charge surface of DNA at lower pH and therefore fails to act as a stabilizing agent for DNA in our in vitro experiments.
Testing socio-cultural valuation methods of ecosystem services to explain land use preferences
(2017)
Socio-cultural valuation still emerges as a methodological field in ecosystem service (ES) research and until now lacks consistent formalisation and balanced application in ES assessments. In this study, we examine the explanatory value of ES values for land use preferences. We use 563 responses to a survey about the Pentland Hills regional park in Scotland. Specifically, we aim to (1) identify clusters of land use preferences by using a novel visualisation tool, (2) test if socio-cultural values of ESs or (3) user characteristics are linked with land use preferences, and (4) determine whether both socio-cultural values of ESs and user characteristics can predict land use preferences. Our results suggest that there are five groups of people with different land use preferences, ranging from forest and nature enthusiasts to traditionalists, multi-functionalists and recreation seekers. Rating and weighting of ESs and user characteristics were associated with different clusters. Neither socio-cultural values nor user characteristics were suitable predictors for land use preferences. While several studies have explored land use preferences by identifying socio-cultural values in the past, our findings imply that in this case study ES values inform about general perceptions but do not replace the assessment of land use preferences. (C) 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.
Kijko et al. (2016) present various methods to estimate parameters that are relevant for probabilistic seismic-hazard assessment. One of these parameters, although not the most influential, is the maximum possible earthquake magnitude m(max). I show that the proposed estimation of m(max) is based on an erroneous equation related to a misuse of the estimator in Cooke (1979) and leads to unstable results. So far, reported finite estimations of m(max) arise from data selection, because the estimator in Kijko et al. (2016) diverges with finite probability. This finding is independent of the assumed distribution of earthquake magnitudes. For the specific choice of the doubly truncated Gutenberg-Richter distribution, I illustrate the problems by deriving explicit equations. Finally, I conclude that point estimators are generally not a suitable approach to constrain m(max).
During gravitropism, the directional signal of gravity is perceived by gravity-sensing cells called statocytes, leading to asymmetric distribution of auxin in the responding organs. To identify the genes involved in gravity signaling in statocytes, we performed transcriptome analyses of statocyte-deficient Arabidopsis thaliana mutants and found two candidates from the LAZY1 family, AtLAZY1/LAZY1-LIKE1 (LZY1) and AtDRO3/AtNGR1/LZY2. We showed that LZY1, LZY2, and a paralog AtDRO1/AtNGR2/LZY3 are redundantly involved in gravitropism of the inflorescence stem, hypocotyl, and root. Mutations of LZY genes affected early processes in gravity signal transduction without affecting amyloplast sedimentation. Statocyte-specific expression of LZY genes rescued the mutant phenotype, suggesting that LZY genes mediate gravity signaling in statocytes downstream of amyloplast displacement, leading to the generation of asymmetric auxin distribution in gravity-responding organs. We also found that lzy mutations reversed the growth angle of lateral branches and roots. Moreover, expression of the conserved C-terminal region of LZY proteins also reversed the growth direction of primary roots in the lzy mutant background. In lateral root tips of lzy multiple mutants, asymmetric distribution of PIN3 and auxin response were reversed, suggesting that LZY genes regulate the direction of polar auxin transport in response to gravity through the control of asymmetric PIN3 expression in the root cap columella.
We report the chronological construction for the top portion of a speleothem, PC1, from southern Cambodia with the aim of reconstructing a continuous high-resolution climate record covering the fluorescence and decline of the medieval Khmer kingdom and its capital at Angkor (similar to 9th-15th centuries AD). Earlier attempts to date PC1 by the standard U-Th method proved unsuccessful. We have therefore dated this speleothem using radiocarbon. Fifty carbonate samples along the growth axis of PC1 were collected for accelerator mass spectrometry (AMS) analysis. Chronological reconstruction for PC1 was achieved using two different approaches described by Hua et al. (2012a) and Lechleitner et al. (2016a). Excellent concordance between the two age-depth models indicates that the top similar to 47 mm of PC1 grew during the last millennium with a growth hiatus during similar to 1250-1650 AD, resulting from a large change in measured C-14 values at 34.4-35.2 mm depth. The timing of the growth hiatus covers the period of decades-long droughts during the 14th-16th centuries AD indicated in regional climate records.
Several scholars concerned with global policy-making have recently pointed to a reconfiguration of authority in the area of climate politics. They have shown that various new carbon governance arrangements have emerged, which operate simultaneously at different governmental levels. However, despite the numerous descriptions and mapping exercises of these governance arrangements, we have little systematic knowledge on their workings within national jurisdictions, let alone about their impact on public-administrative systems in developing countries. Therefore, this article opens the black box of the nation-state and explores how and to what extent two different arrangements, that is, Transnational City Networks and Reducing Emissions from Deforestation and Forest Degradation, generate changes in the distribution of public authority in nation-states and their administrations. Building upon conceptual assumptions that the former is likely to lead to more decentralized, and the latter to more centralized policy-making, we provide insights from case studies in Indonesia, South Africa, Brazil, and India. In a nutshell, our analysis underscores that Transnational City Networks strengthen climate-related actions taken by cities without ultimately decentralizing climate policy-making. On the other hand, Reducing Emissions from Deforestation and Forest Degradation tends to reinforce the competencies of central governments, but apparently does not generate a recentralization of the forestry sector at large.
On the basis of many years of personal experience the paper describes Buddhist meditation (Zazen, Vipassanā) as a mystical practice. After a short discussion of the role of some central concepts (longing, suffering, and love) in Buddhism, William James’ concept of religious experience is used to explain the goal of meditators as the achievement of a special kind of an experience of this kind. Systematically, its main point is to explain the difference between (on the one hand) a craving for pleasant ‘mental events’ in the sense of short-term moods, and (on the other) the long-term project of achieving a deep change in one’s attitude to life as a whole, a change that allows the acceptance of suffering and death. The last part argues that there is no reason to call the discussed practice irrational in a negative sense. Changes of attitude of the discussed kind cannot be brought about by argument alone. Therefore, a considered use of age-old practices like meditation should be seen as an addition, not as an undermining of reason.
Scarce research about small European rivers from non-human impacted areas to determine their natural background state has been undertaken. During the annual hydrological cycle of 2008-9 the patterns of particulate supply (SPM, POC, PON, Al, Cd, Co, Cr, Cu, Fe, Ni, Pb, V, Zn) from the rivers Sor, Mera Landro, Lourido and Landoi to the Northern Galician Rias (SW Bay of Biscay) were tackled. No differences in the composition of the SPM were detected for the studied rivers regarding Al, Fe and POC but the relative percentage of particulate trace elements (PTE) discriminate the rivers. So, Cr, Co and Ni in the Lourido, and Landoi rivers, and Cu in the Mera River, are controlled by watershed minerals of Ortegal Geological Complex while for the rest rivers PTE are by granitic and Ollo de Sapo bedrock watershed. Therefore, the imprint of PTE in the parental rocks of the river basins is reflected on the coastal sediments of the Rias. The main process controlling the dynamics and variations of chemical elements in the particulate form is the river discharge. This fact exemplifies that these rivers presents a natural behavior not being highly influenced by anthropogenic activities.
Reaching the Sustainable Development Goals requires a fundamental socio-economic transformation accompanied by substantial investment in low-carbon infrastructure. Such a sustainability transition represents a non-marginal change, driven by behavioral factors and systemic interactions. However, typical economic models used to assess a sustainability transition focus on marginal changes around a local optimum, whichby constructionlead to negative effects. Thus, these models do not allow evaluating a sustainability transition that might have substantial positive effects. This paper examines which mechanisms need to be included in a standard computable general equilibrium model to overcome these limitations and to give a more comprehensive view of the effects of climate change mitigation. Simulation results show that, given an ambitious greenhouse gas emission constraint and a price of carbon, positive economic effects are possible if (1) technical progress results (partly) endogenously from the model and (2) a policy intervention triggering an increase of investment is introduced. Additionally, if (3) the investment behavior of firms is influenced by their sales expectations, the effects are amplified. The results provide suggestions for policy-makers, because the outcome indicates that investment-oriented climate policies can lead to more desirable outcomes in economic, social and environmental terms.
This review analyzes the potential role and long-term effects of field perennial polycultures (mixtures) in agricultural systems, with the aim of reducing the trade-offs between provisioning and regulating ecosystem services. First, crop rotations are identified as a suitable tool for the assessment of the long-term effects of perennial polycultures on ecosystem services, which are not visible at the single-crop level. Second, the ability of perennial polycultures to support ecosystem services when used in crop rotations is quantified through eight agricultural ecosystem services. Legume-grass mixtures and wildflower mixtures are used as examples of perennial polycultures, and compared with silage maize as a typical crop for biomass production. Perennial polycultures enhance soil fertility, soil protection, climate regulation, pollination, pest and weed control, and landscape aesthetics compared with maize. They also score lower for biomass production compared with maize, which confirms the trade-off between provisioning and regulating ecosystem services. However, the additional positive factors provided by perennial polycultures, such as reduced costs for mineral fertilizer, pesticides, and soil tillage, and a significant preceding crop effect that increases the yields of subsequent crops, should be taken into account. However, a full assessment of agricultural ecosystem services requires a more holistic analysis that is beyond the capabilities of current frameworks.
From blind shorthand
(2017)
This essay explores the poetics of obscurity that informs Luis Chitarroni’s « unfinished novel » The No Variations. Focusing on the « reticent » erudition that distinguishes this text, my analysis examines its dialogue with the paradigm of Borges’ erudition and narrative poetics, as well as with certain « counter-Borgesian » constellations in recent Argentine literature. My reading aims to show how Chitarroni’s anti-novel reactivates a specific Argentinean tradition of productive illegibility while considering how it relates to the practices of « impediment » and « aesthetic reduction » that pervade modern art and literature.
Janus emulsions, containing olive oil (OO) and silicone oil (SiO), were formed in presence of polyelectrolyte complex particles, i.e., gelatin-sodium polyacrylate (NaPAA) complexes. The diameter of completely engulfed Janus droplets can be tuned between 50 and 200 mu m by varying the gelatin/NaPAA complex particle size between 200 and 400 nm. The gelatin/NaPAA complex particles adsorbed at the olive oil interface decrease the interfacial tension and stabilize the resulting completely engulfed Pickering Janus emulsions. Long-term stable Janus gels can be synthesized in presence of gelatin/sodium carboxymethylcellulose (NaCMC) mixtures. In that case Coulombic forces are of relevance with regard to the stabilization of the Janus droplets embedded in a gelatin/NaCMC gel matrix. Janus gels show elastic reological behavior and thixotropic properties.
The amplified spontaneous emission from a superluminescent diode was frequency doubled in a periodically poled lithium niobate waveguide crystal. The temporally incoherent radiation of such a superluminescent diode is characterized by a relatively broad spectral bandwidth and thermal-like photon statistics, as the measured degree of second order coherence, g((2))(0)= 1.9 +/- 0.1, indicates. Despite the non-optimized scenario in the spectral domain, we achieve six orders of magnitude higher conversion efficiency than previously reported with truly incoherent light. This is possible by using single spatial mode radiation and quasi phase matched material with a waveguide architecture. This work is a principle step towards efficient frequency conversion of temporally incoherent radiation in one spatial mode to access wavelengths where no radiation from superluminescent diodes is available, especially with tailored quasi phase matched crystals. The frequency doubled light might find application in imaging, metrology and quantum optics experiments.
This is the first of a series of papers presenting the results from our survey of 25 Galactic globular clusters with the MUSE integral-field spectrograph. In combination with our dedicated algorithm for source deblending, MUSE provides unique multiplex capabilities in crowded stellar fields and allows us to acquire samples of up to 20 000 stars within the half-light radius of each cluster. The present paper focuses on the analysis of the internal dynamics of 22 out of the 25 clusters, using about 500 000 spectra of 200 000 individual stars. Thanks to the large stellar samples per cluster, we are able to perform a detailed analysis of the central rotation and dispersion fields using both radial profiles and two-dimensional maps. The velocity dispersion profiles we derive show a good general agreement with existing radial velocity studies but typically reach closer to the cluster centres. By comparison with proper motion data, we derive or update the dynamical distance estimates to 14 clusters. Compared to previous dynamical distance estimates for 47 Tuc, our value is in much better agreement with other methods. We further find significant (>3 sigma) rotation in the majority (13/22) of our clusters. Our analysis seems to confirm earlier findings of a link between rotation and the ellipticities of globular clusters. In addition, we find a correlation between the strengths of internal rotation and the relaxation times of the clusters, suggesting that the central rotation fields are relics of the cluster formation that are gradually dissipated via two-body relaxation.
Sequelae of prematurity triggered by oxidative stress and free radical-mediated tissue damage have coined the term “oxygen radical disease of prematurity”. Caffeine, a potent free radical scavenger and adenosine receptor antagonist, reduces rates of brain damage in preterm infants. In the present study, we investigated the effects of caffeine on oxidative stress markers, anti-oxidative response, inflammation, redox-sensitive transcription factors, apoptosis, and extracellular matrix following the induction of hyperoxia in neonatal rats. The brain of a rat pups at postnatal Day 6 (P6) corresponds to that of a human fetal brain at 28–32 weeks gestation and the neonatal rat is an ideal model in which to investigate effects of oxidative stress and neuroprotection of caffeine on the developing brain. Six-day-old Wistar rats were pre-treated with caffeine and exposed to 80% oxygen for 24 and 48 h. Caffeine reduced oxidative stress marker (heme oxygenase-1, lipid peroxidation, hydrogen peroxide, and glutamate-cysteine ligase catalytic subunit (GCLC)), promoted anti-oxidative response (superoxide dismutase, peroxiredoxin 1, and sulfiredoxin 1), down-regulated pro-inflammatory cytokines, modulated redox-sensitive transcription factor expression (Nrf2/Keap1, and NFκB), reduced pro-apoptotic effectors (poly (ADP-ribose) polymerase-1 (PARP-1), apoptosis inducing factor (AIF), and caspase-3), and diminished extracellular matrix degeneration (matrix metalloproteinases (MMP) 2, and inhibitor of metalloproteinase (TIMP) 1/2). Our study affirms that caffeine is a pleiotropic neuroprotective drug in the developing brain due to its anti-oxidant, anti-inflammatory, and anti-apoptotic properties.
Entre los mundos
(2017)
The paper deals with the increasing growth of embedded systems and their role within structures similar to the Internet (Internet of Things) as those that provide calculating power and are more or less appropriate for analytical tasks. Faced with the example of a cyber-physical manufacturing system, a common objective function is developed with the intention to measure efficient task processing within analytical infrastructures. A first validation is realized on base of an expert panel.
Bürgerpartizipation
(2017)
Despite high institutional hurdles for constitutional change, one observes surprisingly many EU treaty revisions. This article takes up the questions of what determines whether a treaty provision is successfully changed and why provisions are renegotiated at subsequent Intergovernmental Conferences. The article presents an institutionalist theory explaining success and renegotiation and tests the theory using all core institutional provisions by means of Qualitative Comparative Analysis. The causal analysis shows that low conflict potential of an issue is sufficient for successfully changing the treaties. Furthermore, high conflict potential of an issue and its fundamental change are sufficient for it to be renegotiated.
Winter precipitation forecast in the European and mediterranean regions using cluster analysis
(2017)
The European climate is changing under global warming, and especially the Mediterranean region has been identified as a hot spot for climate change with climate models projecting a reduction in winter rainfall and a very pronounced increase in summertime heat waves. These trends are already detectable over the historic period. Hence, it is beneficial to forecast seasonal droughts well in advance so that water managers and stakeholders can prepare to mitigate deleterious impacts. We developed a new cluster-based empirical forecast method to predict precipitation anomalies in winter. This algorithm considers not only the strength but also the pattern of the precursors. We compare our algorithm with dynamic forecast models and a canonical correlation analysis-based prediction method demonstrating that our prediction method performs better in terms of time and pattern correlation in the Mediterranean and European regions.
The past few years have witnessed the emergence of a plethora of transnational climate governance experiments. They have been developed by a broad range of actors, such as cities, non-profit organizations, and private corporations. Several scholars have lately devoted particular attention to voluntary global business initiatives in the policy domain of climate change. Their studies have provided considerable insights into the role and function of such new modes of climate governance. However, the precise nature of the relationship between the various climate governance experiments and the international climate negotiations has not been analyzed in enough detail. Against this backdrop, the present article explores the interplay of a business sector climate governance experiment, i.e. the Greenhouse Gas Protocol (GHG Protocol) with the international climate regime. On the one hand, the article underscores that the GHG Protocol has filled a regulatory gap in global climate policy-making by providing the means for the corporate sector to comprehensively account and report their GHGs. On the other hand, it reveals that the application of the GHG Protocol guidelines depends to a large extent on the existence of an overarching policy framework set up by nation-states at the intergovernmental level. Only if private companies receive a clear political signal that stringent mandatory GHG emission controls and a global market-based instrument are at least likely to be adopted will they put substantial efforts into the accurate measurement and management of their GHGs. Thus, this article points to the limits of climate governance experimentation and suggests that business sector climate governance experiments need to be embedded in a coherent international regulatory setting which generates a clear stimulus for corporate action.
The shape of trait distributions may inform about the selective forces that structure ecological communities. Here, we present a new moment-based approach to classify the shape of observed biomass-weighted trait distributions into normal, peaked, skewed, or bimodal that facilitates spatio-temporal and cross-system comparisons. Our observed phytoplankton trait distributions exhibited substantial variance and were mostly skewed or bimodal rather than normal. Additionally, mean, variance, skewness und kurtosis were strongly correlated. This is in conflict with trait-based aggregate models that often assume normally distributed trait values and small variances. Given these discrepancies between our data and general model assumptions we used the observed trait distributions to test how well different aggregate models with first- or second-order approximations and different types of moment closure predict the biomass, mean trait, and trait variance dynamics using weakly or moderately nonlinear fitness functions. For weakly non-linear fitness functions aggregate models with a second-order approximation and a data-based moment closure that relied on the observed correlations between skewness and mean, and kurtosis and variance predicted biomass and often also mean trait changes fairly well and better than models with first-order approximations or a normal-based moment closure. In contrast, none of the models reflected the changes of the trait variances reliably. Aggregate model performance was often also poor for moderately nonlinear fitness functions. This questions a general applicability of the normal-based approach, in particular for predicting variance dynamics determining the speed of trait changes and maintenance of biodiversity. We evaluate in detail how and why better approximations can be obtained.
Analytic Kantianism
(2017)
Wilfrid Sellars and John McDowell can both be read as proponents of Analytic Kantianism. However, their accounts differ in important detail. In particular, McDowell has criticized Sellars’s account of sensory consciousness in a number of papers (most notably in LFI and SC), both as a reading of Kant and on its systematic merits. The present paper offers a detailed analysis of this criticism and a defense of Sellars’s position against the background of a methodology of transcendental philosophy.
The review describes how morphological priming can be utilised to study the processing of morphologically complex words in bilinguals. The article starts with an overview of established experimental paradigms based on morphological priming, discusses a number of basic methodological pitfalls with regard to experimental design and materials, then reviews previous L2 morphological priming studies, and concludes with a brief discussion of recent developments in the field as well as possible future directions.
BackgroundDisruptions of reading processes due to text substitutions can measure how readers use lexical information. MethodsWith eye-movement recording, children and adults viewed sentences with either identical, orthographically similar, homophonic or unrelated substitutions of the first characters in target words. To the extent that readers rely on orthographic or phonological cues, substitutions that contain such cues should cause less disruption reading than do unrelated substitutions. ResultsOn pretarget words, there was a reliable reduction in gaze duration due to homophonic substitution only for children. On target words, we observed reliable recovery effects due to orthographic similarity for adults. On post-target words, adults had better orthographic-based and phonological-based recovery abilities than children. ConclusionsThe combination of eye movement recording and the error detection paradigm offers a novel implicit paradigm for studying reading development: during sentence reading, beginning readers of Chinese may rely on phonological mediation, while skilled readers have more direct access to semantics from orthography.
Cognitive or executive control is a critical mental ability, an important marker of mental illness, and among the most heritable of neurocognitive traits. Two candidate genes, catechol-O-methyltransferase (COMT) and DRD4, which both have a roles in the regulation of cortical dopamine, have been consistently associated with cognitive control. Here, we predicted that individuals with the COMT Met/Met allele would show improved response execution and inhibition as indexed by event-related potentials in a Go/NoGo task, while individuals with the DRD4 7-repeat allele would show impaired brain activity. We used independent component analysis (ICA) to separate brain source processes contributing to high-density EEG scalp signals recorded during the task. As expected, individuals with the DRD4 7-repeat polymorphism had reduced parietal P3 source and scalp responses to response (Go) compared to those without the 7-repeat. Contrary to our expectation, the COMT homozygous Met allele was associated with a smaller frontal P3 source and scalp response to response-inhibition (NoGo) stimuli, suggesting that while more dopamine in frontal cortical areas has advantages in some tasks, it may also compromise response inhibition function. An interaction effect emerged for P3 source responses to Go stimuli. These were reduced in those with both the 7-repeat DRD4 allele and either the COMT Val/Val or the Met/Met homozygous polymorphisms but not in those with the heterozygous Val/Met polymorphism. This epistatic interaction between DRD4 and COMT replicates findings that too little or too much dopamine impairs cognitive control. The anatomic and functional separated maximally independent cortical EEG sources proved more informative than scalp channel measures for genetic studies of brain function and thus better elucidate the complex mechanisms in psychiatric illness.
5-Jahres-Verlauf der LRS
(2017)
Fragestellung: Untersucht wird der Verlauf von Kindern mit Lese-Rechtschreibstörungen (LRS) über gut 5 Jahre unter Berücksichtigung des Einflusses des Geschlechts der Betroffenen. Außerdem werden Auswirkungen der LRS auf das spätere Schriftsprachniveau und den Schulerfolg überprüft. Methodik: Eingangs wurden 995 Schüler zwischen 6 und 16 Jahren untersucht. Ein Teil dieser Kinder ist nach 43 sowie 63 Monaten nachuntersucht worden. Eine LRS wurde diagnostiziert, wenn für das Lesen bzw. Rechtschreiben das doppelte Diskrepanzkriterium von 1.5 Standardabweichungen zur nonverbalen Intelligenz und dem Mittelwert der Klassenstufe erfüllt war und gleichzeitig keine Minderbegabung vorlag. Ergebnisse: Die LRS weist über einen Zeitraum von 63 Monaten eine hohe Störungspersistenz von knapp 70 % auf. Der 5-Jahres-Verlauf der mittleren Lese- und Rechtschreibleistungen wurde nicht vom Geschlecht beeinflusst. Trotz durchschnittlicher Intelligenz blieben die LRS-Schüler in der Schriftsprache mindestens eine Standardabweichung hinter durchschnittlich und etwa 0.5 Standardabweichungseinheiten hinter unterdurchschnittlich intelligenten Kindern zurück. Der Schulerfolg der LRS-Schüler glich dem unterdurchschnittlich intelligenter Kinder und fiel deutlich schlechter aus als bei durchschnittlich intelligenten Kontrollkindern. Schlussfolgerungen: Eine LRS stellt ein erhebliches Entwicklungsrisiko dar, was frühzeitige Diagnostik- und Therapiemaßnahmen erfordert. Dafür sind reliable und im Hinblick auf die resultierenden Prävalenzraten sinnvolle, allgemein anerkannte Diagnosekriterien essenziell.
The Chelyabinsk meteorite
(2017)
We present results of petrographic, mineralogical, and chemical investigations of three Chelyabinsk meteorite fragments. Three distinct lithologies were identified: light S3LL5, dark S4-S5LL5 material, and opaque fine-grained former impact melt. Olivine-spinel thermometry revealed an equilibration temperature of 703 +/- 23 degrees C for the light lithology. All plagioclase seems to be secondary, showing neither shock-induced fractures nor sulfide-metal veinlets. Feldspathic glass can be observed showing features of extensive melting and, in the dark lithology, as maskelynite, lacking melt features and retaining grain boundaries of former plagioclase. Olivine of the dark lithology shows planar deformation features. Impact melt is dominated by Mg-rich olivine and resembles whole-rock melt. Melt veins (<2mm) are connected to narrower veinlets. Melt vein textures are similar to pegmatite textures showing chilled margins, a zone of inward-grown elongated crystals and central vugs, suggesting crystallization from supercooled melt. Sulfide-metal droplets indicate liquid immiscibility of both silicate and sulfide as well as sulfide and metal melts. Impact melting may have been an important factor for differentiation of primitive planetary bodies. Graphite associated with micrometer-sized melt inclusions in primary olivine was detected by Raman mapping. Carbon isotopic studies of graphite could be applied to test a possible presolar origin.
The uplift of the Shillong Plateau, in northeast India between the Bengal floodplain and the Himalaya Mountains, has had a significant impact on regional precipitation patterns, strain partitioning, and the path of the Brahmaputra River. Today, the plateau receives the highest measured yearly rainfall in the world and is tectonically active, having hosted one of the strongest intra-plate earthquakes ever recorded. Despite the unique tectonic and climatic setting of this prominent landscape feature, its exhumation and surface uplift history are poorly constrained. We collected 14 detrital river sand and 3 bedrock samples from the southern margin of the Shillong Plateau to measure erosion rates using the terrestrial cosmogenic nuclide 10Be. The calculated bedrock erosion rates range from 2.0 to 5.6 m My−1, whereas catchment average erosion rates from detrital river sands range from 48 to 214 m My−1. These rates are surprisingly low in the context of steep, tectonically active slopes and extreme rainfall. Moreover, the highest among these rates, which occur on the low-relief plateau surface, appear to have been affected by anthropogenic land-use change. To determine the onset of surface uplift, we coupled the catchment averaged erosion rates with topographic analyses of the plateau's southern margin. We interpolated an inclined, pre-incision surface from minimally eroded remnants along the valley interfluves and calculated the eroded volume of the valleys carved beneath the surface. The missing volume was then divided by the volume flux derived from the erosion rates to obtain the onset of uplift. The results of this calculation, ranging from 3.0 to 5.0 Ma for individual valleys, are in agreement with several lines of stratigraphic evidence from the Brahmaputra and Bengal basin that constrain the onset of topographic uplift, specifically the onset of flexural loading and the transgression from deltaic to marine deposition. Ultimately, our data corroborate the hypothesis that surface uplift was decoupled from the onset of rapid exhumation, which occurred several millions of years earlier.
To better assess ecosystem C budgets of croplands and understand their potential response to climate and management changes, detailed information on the mechanisms and environmental controls driving the individual C flux components are needed. This accounts in particular for the ecosystem respiration (R-eco) and its components, the autotrophic (R-a) and heterotrophic respiration (R-h) which vary tremendously in time and space. This study presents a method to separate R-eco into R-a [as the sum of R-a (shoot) and R-a (root)] and R-h in order to detect temporal and small-scale spatial dynamics within their relative contribution to overall R-eco. Thus, predominant environmental drivers and underlying mechanisms can be revealed. R-eco was derived during nighttime by automatic chamber CO2 flux measurements on plant covered plots. R-h was derived from CO2 efflux measurements, which were performed in parallel to R-eco measurements on a fallow plot using CO2 sampling tubes in 10 cm soil depth. R-a (root) was calculated as the difference between sampling tube CO2 efflux measurements on a plant covered plot and R-h. R-a (shoot) was calculated as R-eco - R-a (root) - R-h. Measurements were carried out for winter wheat (Triticum aestivum L.) during the crop season 2015 at an experimental plot located in the hummocky ground moraine landscape of NE Germany. R-eco varied seasonally from < 1 to 9.5 g C m(-2) d(-1), and was higher in adult (a) and reproductive (r) than juvenile (j) stands (gC m(-2) d(-1): j = 1.2, a = 4.6, r = 5.3). Observed R-a and R-h were in general smaller compared to the independently measured R-eco, contributing in average 58% and 42% to R-eco. However, both varied strongly regarding their environmental drivers and particular contribution throughout the study period, following the seasonal development of soil temperature and moisture (R-h) as well as crop development (R-a). Thus, our results consistently revealed temporal dynamics regarding the relative contribution of R-a (root) and R-a (shoot) to R-a, as well as of R-a and R-h to R-eco. Based on the observed results, implications for partitioning of R-eco in croplands are given.
Fortsetzung aus Ernährungs Umschau Heft 9/2017
Fettsäurenverteilung
Die Gehalte an den wichtigsten Fettsäuren (FS) sind in • Tabelle 4 und 5 aufgeführt, in g/100 g sowie in Prozent des Fettanteils (Etherextrakt bzw. g FS-Methylester pro 100 g der Summe der FS-Methylester). Erbsen und Ackerbohnen spielen als Fett- und FS-Quelle praktisch keine Rolle. Sojabohnen sind eine wesentliche Quelle für Linolsäure, die häufigste n-6-FS. An zweiter Stelle steht die Ölsäure. Aber auch der Gehalt an der n-3-FS α-Linolensäure (ALA) ist hoch, womit sich Sojaöl in die Reihe der Fette mit mittlerem ALA-Gehalt, wie Raps- und Walnussöl einreiht. Im Gegensatz zu Rapsöl entspricht jedoch das Linolsäure/α-Linolensäure- Verhältnis nicht dem empfohlenen Verhältnis von 5:1 in der Gesamt- Diät [13]. Zum Ausgleich für die Fette aus der übrigen Nahrung (Getreide, Lebensmittel tierischer Herkunft) sollten Pflanzenöle besser noch ein engeres Verhältnis als 5:1 aufweisen. Das trifft für Lupinen-Öl schon eher zu, wenngleich der absolute Beitrag an ALA hier eher gering ist.
Potato (Solanum tuberosum L.) is one of the most important food crops worldwide. Current potato varieties are highly susceptible to drought stress. In view of global climate change, selection of cultivars with improved drought tolerance and high yield potential is of paramount importance. Drought tolerance breeding of potato is currently based on direct selection according to yield and phenotypic traits and requires multiple trials under drought conditions. Marker-assisted selection (MAS) is cheaper, faster and reduces classification errors caused by noncontrolled environmental effects. We analysed 31 potato cultivars grown under optimal and reduced water supply in six independent field trials. Drought tolerance was determined as tuber starch yield. Leaf samples from young plants were screened for preselected transcript and nontargeted metabolite abundance using qRT-PCR and GC-MS profiling, respectively. Transcript marker candidates were selected from a published RNA-Seq data set. A Random Forest machine learning approach extracted metabolite and transcript markers for drought tolerance prediction with low error rates of 6% and 9%, respectively. Moreover, by combining transcript and metabolite markers, the prediction error was reduced to 4.3%. Feature selection from Random Forest models allowed model minimization, yielding a minimal combination of only 20 metabolite and transcript markers that were successfully tested for their reproducibility in 16 independent agronomic field trials. We demonstrate that a minimum combination of transcript and metabolite markers sampled at early cultivation stages predicts potato yield stability under drought largely independent of seasonal and regional agronomic conditions.
Postpartale Depressionen sind häufige und schwerwiegende psychische Erkrankungen mit ungünstigem Einfluss auf die kindliche Entwicklung. Als Haupttransmissionsweg gilt die frühe Mutter-Kind-Interaktion. Über die langfristigen Auswirkungen auf die Kinder im Erwachsenenalter und die Rolle der Interaktion liegen kaum Ergebnisse vor. Im Rahmen der Mannheimer Risikokinderstudie wurden postpartale Depressionen bis zwei Jahre nach der Geburt erfasst. Die kindliche Entwicklung wurde fortlaufend und die Mutter-Kind-Interaktion im Alter von 3 Monaten standardisiert erhoben. 28 Kinder postpartal depressiver und 107 Kinder gesunder Mütter konnten mit 25 Jahren untersucht werden. Beeinträchtigungen der kognitiven und psychischen Entwicklung bei Kindern postpartal depressiver Mütter waren bis ins Erwachsenenalter nachweisbar. Responsives bzw. sensitives mütterliches Verhalten wirkte der negativen Entwicklung entgegen. Dies betont die Bedeutung einer hohen Qualität der Mutter-Kind-Interaktion für die Entwicklung von Risikokindern.
Die langfristigen Auswirkungen von Frühgeburtlichkeit auf kognitive Entwicklung und Schulerfolg
(2017)
In einer prospektiven Längsschnittstudie wurde der Zusammenhang zwischen früher Responsivität der Mutter und kognitiver Entwicklung ihrer früh- bzw. reifgeborenen Kinder untersucht. Im Alter von drei Monaten wurde dafür die Mutter-Kind-Interaktion mittels Verhaltensbeobachtung erfasst. Bei n=351 der teilnehmenden Kinder (101 frühgeboren) wurde die allgemeine Intelligenz (IQ) im Alter von 11 Jahren und bei n=313 (85 frühgeboren) zusätzlich der höchste erreichte Schulabschluss bis 25 Jahren erhoben. Frühgeborene wiesen mit 11 Jahren einen signifikant niedrigeren IQ als Reifgeborene auf, nachdem für mögliche konfundierende Faktoren kontrolliert worden war. Nur bei Früh-, nicht aber bei Reifgeborenen zeigte sich ein signifikanter positiver Zusammenhang zwischen mütterlicher Responsivität und IQ. Für die Wahrscheinlichkeit einen höheren Schulabschluss (mind. Fachabitur) zu erreichen, fand sich weder ein signifikanter Effekt von Frühgeburtlichkeit noch von mütterlicher Responsivität.
We describe the Multilanguage Written Picture Naming Dataset. This gives trial-level data and time and agreement norms for written naming of the 260 pictures of everyday objects that compose the colorized Snodgrass and Vanderwart picture set (Rossion & Pourtois in Perception, 33, 217-236, 2004). Adult participants gave keyboarded responses in their first language under controlled experimental conditions (N = 1,274, with subsamples responding in Bulgarian, Dutch, English, Finnish, French, German, Greek, Icelandic, Italian, Norwegian, Portuguese, Russian, Spanish, and Swedish). We measured the time to initiate a response (RT) and interkeypress intervals, and calculated measures of name and spelling agreement. There was a tendency across all languages for quicker RTs to pictures with higher familiarity, image agreement, and name frequency, and with higher name agreement. Effects of spelling agreement and effects on output rates after writing onset were present in some, but not all, languages. Written naming therefore shows name retrieval effects that are similar to those found in speech, but our findings suggest the need for cross-language comparisons as we seek to understand the orthographic retrieval and/or assembly processes that are specific to written output.
The Cotentin Peninsula (Normandy, France) displays sequences of marine terraces and rasas, the latter being wide Late Cenozoic coastal erosion surfaces, that are typical of Western European coasts in Portugal, Spain, France and southern England. Remote sensing imagery and field mapping enabled reappraisal of the Cotentin coastal sequences. From bottom to top, the N Cotentin sequence includes four previously recognized Pleistocene marine terraces (T1 to T4) at elevations <40 m as well as four higher and older rasas (R1 to R4) reaching 200 +/- 5 m in elevation. Low-standing marine terraces are not observed in the central part of the Peninsula and a limited number of terraces are described to the south. The high-standing rasas are widespread all over the peninsula. Such strandline distributions reveal major changes during the Late Cenozoic. Progressive uplift of an irregular sea-floor led to subaerial exposure of bathymetric highs that were carved into rocky platforms, rasas and marine terraces. Eventually, five main islands coalesced and connected to the mainland to the south to form the Cotentin Peninsula. On the basis of previous dating of the last interglacial maximum terrace (i.e. Marine Isotopic Stage, MIS 5e), sequential morphostratigraphy and modelling, we have reappraised uplift rates and derived: (i) mean Upper Pleistocene (i.e. since MIS 5e similar to 122 +/- 6 ka, i.e. kilo annum) apparent uplift rates of 0.04 +/- 0.01 mm/yr, (ii) mean Middle Pleistocene eustasy-corrected uplift rates of 0.09 +/- 0.03 mm/yr, and (iii) low mean Pleistocene uplift rates of 0.01 mm/yr. Extrapolations of these slow rates combined with geological evidence implies that the formation of the sequences from the Cotentin Peninsula occurred between 3 Ma (Pliocene) and 15 Ma (Miocene), which cannot be narrowed down further without additional research. Along the coasts of Western Europe, sequences of marine terraces and rasas are widespread (169 preserve the MIS Se benchmark). In Spain, Portugal, S England and other parts of western France, the sequences morphostratigraphy is very similar to that of Cotentin. The onset of such Western European sequences occurred during the Miocene (e.g. Spain) or Pliocene (e.g. Portugal). We interpret this Neogene-Quaternary coastal uplift as a symptom of the increasing lithospheric compression that accompanies Cenozoic orogenies. (C) 2017 Elsevier B.V. All rights reserved.
How AAA(+) chaperones conformationally remodel specific target proteins in an ATP-dependent manner is not well understood. Here, we investigated the mechanism of the AAA(+) protein Rubisco activase (Rca) in metabolic repair of the photosynthetic enzyme Rubisco, a complex of eight large (RbcL) and eight small (RbcS) subunits containing eight catalytic sites. Rubisco is prone to inhibition by tight-binding sugar phosphates, whose removal is catalyzed by Rca. We engineered a stable Rca hexamer ring and analyzed its functional interaction with Rubisco. Hydrogen/deuterium exchange and chemical crosslinking showed that Rca structurally destabilizes elements of the Rubisco active site with remarkable selectivity. Cryo-electron microscopy revealed that Rca docks onto Rubisco over one active site at a time, positioning the C-terminal strand of RbcL, which stabilizes the catalytic center, for access to the Rca hexamer pore. The pulling force of Rca is fine-tuned to avoid global destabilization and allow for precise enzyme repair.
This article introduces a new theory, the Affective-Reflective Theory (ART) of physical inactivity and exercise. ART aims to explain and predict behavior in situations in which people either remain in a state of physical inactivity or initiate action (exercise). It is a dual-process model and assumes that exercise-related stimuli trigger automatic associations and a resulting automatic affective valuation of exercise (type-1 process). The automatic affective valuation forms the basis for the reflective evaluation (type-2 process), which can follow if self-control resources are available. The automatic affective valuation is connected with an action impulse, whereas the reflective evaluation can result in action plans. The two processes, in constant interaction, direct the individual towards or away from changing behavior. The ART of physical inactivity and exercise predicts that, when there is an affective-reflective discrepancy and self-control resources are low, behavior is more likely to be governed by the affective type-1 process. This introductory article explains the underlying concepts and main theoretical roots from which the ART of physical inactivity and exercise was developed (field theory, affective responses to exercise, automatic evaluation, evaluation-behavior link, dual-process theorizing). We also summarize the empirical tests that have been conducted to refine the theory in its present form.
Density dependence is of fundamental importance for population and range dynamics. Density-dependent reproduction of plants arises from competitive and facilitative plant-plant interactions that can be pollination independent or pollination mediated. In small and sparse populations, conspecific density dependence often turns from negative to positive and causes Allee effects. Reproduction may also increase with heterospecific density (community-level Allee effect), but the underlying mechanisms are poorly understood and the consequences for community dynamics can be complex. Allee effects have crucial consequences for the conservation of declining species, but also the dynamics of range edge populations. In invasive species, Allee effects may slow or stop range expansion. Observational studies in natural plant communities cannot distinguish whether reproduction is limited by pollination-mediated interactions among plants or by other neighbourhood effects (e.g. competition for abiotic resources). Even experimental pollen supply cannot distinguish whether variation in reproduction is caused by direct density effects or by plant traits correlated with density. Finally, it is unknown over which spatial scales pollination-mediated interactions occur. To circumvent these problems, we introduce a comprehensive experimental and analytical framework which simultaneously (1) manipulates pollen availability and quality by hand pollination and pollinator exclusion, (2) manipulates neighbourhoods by transplanting target plants, and (3) analyses the effects of con- and heterospecific neighbourhoods on reproduction with spatially explicit trait-based neighbourhood models. Synthesis. By manipulating both pollen availability and target plant locations within neighbourhoods, we can comprehensively analyse spatially explicit density dependence of plant reproduction. This experimental approach enhances our ability to understand the dynamics of sparse populations and of species geographical ranges.
From monthly mean observatory data spanning 1957-2014, geomagnetic field secular variation values were calculated by annual differences. Estimates of the spherical harmonic Gauss coefficients of the core field secular variation were then derived by applying a correlation based modelling. Finally, a Fourier transform was applied to the time series of the Gauss coefficients. This process led to reliable temporal spectra of the Gauss coefficients up to spherical harmonic degree 5 or 6, and down to periods as short as 1 or 2 years depending on the coefficient. We observed that a k(-2) slope, where k is the frequency, is an acceptable approximation for these spectra, with possibly an exception for the dipole field. The monthly estimates of the core field secular variation at the observatory sites also show that large and rapid variations of the latter happen. This is an indication that geomagnetic jerks are frequent phenomena and that significant secular variation signals at short time scales - i.e. less than 2 years, could still be extracted from data to reveal an unexplored part of the core dynamics.
Aim: Across the planet, grass-dominated biomes are experiencing shrub encroachment driven by atmospheric CO2 enrichment and land-use change. By altering resource structure and availability, shrub encroachment may have important impacts on vertebrate communities. We sought to determine the magnitude and variability of these effects across climatic gradients, continents, and taxa, and to learn whether shrub thinning restores the structure of vertebrate communities. Location: Worldwide. Time period: Contemporary. Major taxa studied: Terrestrial vertebrates. Methods: We estimated relationships between percentage shrub cover and the structure of terrestrial vertebrate communities (species richness, Shannon diversity and community abundance) in experimentally thinned and unmanipulated shrub-encroached grass-dominated biomes using systematic review and meta-analyses of 43 studies published from 1978 to 2016. We modelled the effects of continent, biome, mean annual precipitation, net primary productivity and the normalized difference vegetation index (NDVI) on the relationship between shrub cover and vertebrate community structure. Results: Species richness, Shannon diversity and total abundance had no consistent relationship with shrub encroachment and experimental thinning did not reverse encroachment effects on vertebrate communities. However, some effects of shrub encroachment on vertebrate communities differed with net primary productivity, amongst vertebrate groups, and across continents. Encroachment had negative effects on vertebrate diversity at low net primary productivity. Mammalian and herpetofaunal diversity decreased with shrub encroachment. Shrub encroachment also had negative effects on species richness and total abundance in Africa but positive effects in North America. Main conclusions: Biodiversity conservation and mitigation efforts responding to shrub encroachment should focus on low-productivity locations, on mammals and herpetofauna, and in Africa. However, targeted research in neglected regions such as central Asia and India will be needed to fill important gaps in our knowledge of shrub encroachment effects on vertebrates. Additionally, our findings provide an impetus for determining the mechanisms associated with changes in vertebrate diversity and abundance in shrub-encroached grass-dominated biomes.
Inside the EU Commission
(2017)
This article studies the perception of the EU Commission's Secretariat General in policy-making. Recently, research on EU institutions devotes increasing attention to analyzing structures and procedures of decision-making in EU institutions, most notably the EU Commission. Conventionally, the EU Commission is portrayed as a fragmented organization, divided along the lines of staff nationality, sectoral responsibilities and cabinets and General Directorates (DGs). The Secretariat General has long been viewed a weak actor that is hardly able or motivated to steer internal decision-making. However, recent research indicates a changing role of the Secretariat General as a pro-active broker and last arbiter. This article studies how the Secretariat General is perceived by the DGs in policy coordination and argues that this perception depends on the pattern of political authority, bureaucratic roles and the relevance and the alternatives prevailing in the policy field. The article is based on data from a survey among Commission officials.
Recent advances in gene function prediction rely on ensemble approaches that integrate results from multiple inference methods to produce superior predictions. Yet, these developments remain largely unexplored in plants. We have explored and compared two methods to integrate 10 gene co-function networks for Arabidopsis thaliana and demonstrate how the integration of these networks produces more accurate gene function predictions for a larger fraction of genes with unknown function. These predictions were used to identify genes involved in mitochondrial complex I formation, and for five of them, we confirmed the predictions experimentally. The ensemble predictions are provided as a user-friendly online database, EnsembleNet. The methods presented here demonstrate that ensemble gene function prediction is a powerful method to boost prediction performance, whereas the EnsembleNet database provides a cutting-edge community tool to guide experimentalists.
Dem Text liegt ein Vortrag zugrunde, der auf dem 31. Motivationspsychologischen Kolloquium (MPK) in Heidelberg 2015 gehalten wurde. Im ersten Teil bietet er einen Überblick über die Motivationsforschung am Bochumer Heckhausen-Lehrstuhl in den 70er-Jahren („Bochumer Schule“). Dabei werden neben Heinz Heckhausen einzelne Mitarbeiter und ihre Schwerpunkte vorgestellt sowie das stimulierende Arbeitsklima an diesem Lehrstuhl beschrieben. Entsprechend der Vortragseinladung wird im Anschluss die Entwicklung der eigenen Forschungsschwerpunkte skizziert. Noch unter Heckhausens Leitung waren dies zunächst die Forschung zur Bezugsnormorientierung und die Einzelfallanalysen zur Lernmotivation mit dem Erweiterten Kognitiven Motivationsmodell. Danach geht der Vortrag auf Forschungsthemen ein, die dann in Heidelberg und Potsdam dazukamen. Hier geht es um die Erforschung von Tätigkeitsanreizen und um das Flow-Erleben. Abschließend wird der Potsdamer Versuch skizziert, herauszufinden, auf welche Weise unterschiedliche Motivationsqualitäten den Lernprozess und seine Resultate beeinflussen.
The invasion success of the cyanobacterium Cylindrospermopsis raciborskii in experimental mesocosms
(2017)
The potentially toxic, invasive cyanobacterium Cylindrospermopsis raciborskii, originating from sub-tropical regions, has spread into temperate climate zones in almost all continents. Potential factors in its success are temperature, light and nutrient levels. Grazing losses through zooplankton have been measured in the laboratory but are typically not regarded as a factor in (failed) invasion success. In some potentially suitable lakes, C. raciborskii has never been found, although it is present in water bodies close by. Therefore, we tested the invasive potential of three different isolates introduced into natural plankton communities using laboratory mesocosm experiments under three grazing levels: ambient zooplankton densities, removal of large species using 100 mu m mesh and a ca. doubling of large species. Three C. raciborskii isolates originating from the same geographic region (North-East Germany) were added separately to the four replicates of each treatment and kept in semi-continuous cultures for 21 days. Two isolates disappeared from the mesocosms and were also not viable in filtered lake water indicating that the lake water itself or the switch from culture medium to lake water led to the decay of the inoculated C. raciborskii. Only one out of the three isolates persisted in the plankton communities at a rather low level and only in the treatment without larger zooplankton. This result demonstrates that under potentially suitable environmental conditions, top-down control from zooplankton might hamper the establishment of C. raciborskii. Non-metric multidimensional scaling showed distinct variation in resident phytoplankton communities between the different grazing levels, thus differential grazing impact shaped the resident community in different ways allowing C. raciborskii only to invade under competitive (= low grazing pressure) conditions. Furthermore, even after invasion failure, the temporary presence of C. raciborskii influenced the phytoplankton community.
We give a new and very short proof of a theorem of Greiner asserting that a positive and contractive -semigroup on an -space is strongly convergent in case it has a strictly positive fixed point and contains an integral operator. Our proof is a streamlined version of a much more general approach to the asymptotic theory of positive semigroups developed recently by the authors. Under the assumptions of Greiner's theorem, this approach becomes particularly elegant and simple. We also give an outlook on several generalisations of this result.
Due to increasing pressure on estuarine marshes from sea level rise and river training, there is a growing need to understand how species-environment relationships influence the zonation and growth of tidal marsh vegetation. In the present study, we investigated the distribution and stand characteristics of the two key brackish marsh species Bolboschoenus maritimus and Phragmites australis in the Elbe estuary together with several abiotic habitat factors. We then tested the effect of these habitat factors on plant growth and zonation with generalised linear models (GLMs). Our study provides detailed information on the importance of single habitat factors and their interactions for controlling the distribution patterns and stand characteristics of two key marsh species. Our results suggest that flow velocity is the main factor influencing species distribution and stand characteristics and together with soil-water salinity even affects the inundation tolerance of the two specie investigated here. Additionally, inundation height and duration as well as interspecific competition helped explain the distribution patterns and stand characteristics. By identifying the drivers of marsh zonation and stand characteristics and quantifying their effects, this study provides useful information for evaluating a future contribution of tidal marsh vegetation to ecosystem-based shore protection.
Much of the literature in the field of international relations is currently concerned with the changing patterns of authority in world politics. This is particularly evident in the policy domain of climate change, where a number of authors have observed a relocation of authority in global climate governance. These scholars claim that multilateral treaty making has lost much of its spark, and they emphasize the emergence of transnational governance arrangements, such as city networks, private certification schemes, and business self-regulation. However, the different types of interactions between the various transnational climate initiatives and the intergovernmental level have not been studied in much detail and only recently attracted growing scholarly interest. Therefore, the present article addresses this issue and focuses on the interplay between three different transnational climate governance arrangements and the international climate regime. The analysis in this article underscores that substate and nonstate actors have attained several authoritative functions in global climate policy making. Nevertheless, the three case studies also demonstrate that this development does not imply that we are witnessing a general shift of authority away from the intergovernmental level toward transnational actors. Instead, what can be observed in global climate governance is an ongoing reconfiguration of authority, which apparently reaffirms the centrality of the international climate regime. Thus, this article points to the need for a more nuanced perspective on the changing patterns of authority in global climate governance. In a nutshell, this study shows that the international climate regime is not the only location where the problem of climate change is addressed, while it highlights the persistent authority of state-based forms of regulation.
Narratives of Belonging
(2017)
Die Darstellungen genealogischer Netzwerke waren in der Antike Ausdruck der Weltsicht ihrer Erzähler, mit deren Hilfe Nähe und Distanz zwischen verschiedenen Gruppen und Völkern ausgedrückt und hergestellt werden konnte. Auch Paulus bedient sich genealogischer Argumente, um die Beziehung nicht-jüdischer Christus-Gläubiger zu Israel und ihrem Gott zu verdeutlichen. Es handelt sich um eine ethnozentrische Argumentation, deren Fokus aber gleichzeitig eindeutig theozentrisch ist.
Using a standard repeated measures model with arbitrary true score distribution and normal error variables, we present some fundamental closed-form results which explicitly indicate the conditions under which regression effects towards (RTM) and away from the mean are expected. Specifically, we show that for skewed and bimodal distributions many or even most cases will show a regression effect that is in expectation away from the mean, or that is not just towards but actually beyond the mean. We illustrate our results in quantitative detail with typical examples from experimental and biometric applications, which exhibit a clear regression away from the mean (‘egression from the mean’) signature. We aim not to repeal cautionary advice against potential RTM effects, but to present a balanced view of regression effects, based on a clear identification of the conditions governing the form that regression effects take in repeated measures designs.
High resolution reconstructions of the India Summer Monsoon (ISM) are essential to identify regionally different patterns of climate change and refine predictive models. We find opposing trends of hydrological proxies between northern (Sahiya cave stalagmite) and central India (Lonar Lake) between 100 and 1300 CE with the strongest anti-correlation between 810 and 1300 CE. The apparently contradictory data raise the question if these are related to widely different regional precipitation patterns or reflect human influence in/around the Lonar Lake. By comparing multiproxy data with historical records, we demonstrate that only the organic proxies in the Lonar Lake show evidence of anthropogenic impact. However, evaporite data (mineralogy and delta O-18) are indicative of precipitation/evaporation (P/E) into the Lonar Lake. Back-trajectories of air-mass circulation over northern and central India show that the relative contribution of the Bay of Bengal (BoB) branch of the ISM is crucial for determining the delta O-18 of carbonate proxies only in north India, whereas central India is affected significantly by the Arabian Sea (AS) branch of the ISM. We conclude that the delta O-18 of evaporative carbonates in the Lonar Lake reflects P/E and, in the interval under consideration, is not influenced by source water changes. The opposing trend between central and northern India can be explained by (i) persistent multidecadal droughts over central India between 810 and 1300 CE that provided an effective mechanism for strengthening sub-tropical westerly winds resulting in enhancement of wintertime (non-monsoonal) rainfall over northern parts of the Indian subcontinent, and/or (ii) increased moisture influx to northern India from the depleted BoB source waters.
Sucrose nonfermenting related kinase1 (SnRK1) is a conserved energy sensor kinase that regulates cellular adaptation to energy deficit in plants. Activation of SnRK1 leads to the down-regulation of ATP-consuming biosynthetic processes and the stimulation of energy-generating catabolic reactions by transcriptional reprogramming and posttranslational modifications. Although considerable progress has been made during the last years in understanding the SnRK1 signaling pathway, many of its components remain unidentified. Here, we show that the catalytic alpha-subunits KIN10 and KIN11 of the Arabidopsis (Arabidopsis thaliana) SnRK1 complex interact with the STOREKEEPER RELATED1/G-Element Binding Protein (STKR1) inside the plant cell nucleus. Overexpression of STKR1 in transgenic Arabidopsis plants led to reduced growth, a delay in flowering, and strongly attenuated senescence. Metabolite profiling revealed that the transgenic lines exhausted their carbohydrates during the dark period to a greater extent than the wild type and accumulated a range of amino acids. At the global transcriptome level, genes affected by STKR1 overexpression were broadly associated with systemic acquired resistance, and transgenic plants showed enhanced resistance toward a virulent strain of the biotrophic oomycete pathogen Hyaloperonospora arabidopsidis Noco2. We discuss a possible connection of STKR1 function, SnRK1 signaling, and plant immunity.
The past two decades have witnessed widespread scholarly interest in the role of cities in climate policy-making. This research has considerably improved our understanding of the local level in the global response to climate change. The present article synthesizes the literature on local climate policies with respect to the 1.5 degrees C target. While most studies have focused on pioneering cities and networks, we contend that the broader impacts of local climate actions and their relationship to regional, national, and international policy frameworks have not been studied in enough detail. Against this backdrop, we introduce the concept of upscaling and contend that local climate initiatives must go hand in hand with higher-level policies and be better integrated into the multi-level governance system.
Scientific Objectives of Electron Losses and Fields INvestigation Onboard Lomonosov Satellite
(2017)
The objective of the Electron Losses and Fields INvestigation on board the Lomonosov satellite ( ELFIN-L) project is to determine the energy spectrum of precipitating energetic electrons and ions and, together with other polar-orbiting and equatorial missions, to better understand the mechanisms responsible for scattering these particles into the atmosphere. This mission will provide detailed measurements of the radiation environment at low altitudes. The 400-500 km sun-synchronous orbit of Lomonosov is ideal for observing electrons and ions precipitating into the atmosphere. This mission provides a unique opportunity to test the instruments. Similar suite of instruments will be flown in the future NSF-and NASA-supported spinning CubeSat ELFIN satellites which will augment current measurements by providing detailed information on pitch-angle distributions of precipitating and trapped particles.
Circumstantial evidence suggests that magnetism and enhanced X-ray emission are likely correlated in early B-type stars: similar fractions of them (similar to 10%) are strong and hard X-ray sources and possess strong magnetic fields. It is also known that some B-type stars have spots on their surface. Yet up to now no X-ray activity associated with spots on early-type stars was detected. In this Letter we report the detection of a magnetic field on the B2V star rho Oph A. Previously, we assessed that the X-ray activity of this star is associated with a surface spot, herewith we establish its magnetic origin. We analyze spectra of rho Oph A obtained with the FORS2 spectrograph at ESO Very Large Telescope (VLT) at two epochs, and detect a longitudinal component of the magnetic field of the order of similar to 500 G in one of the datasets. The detection of the magnetic field only at one epoch can be explained by stellar rotation which is also invoked to explain observed periodic X-ray activity. From archival HARPS ESO VLT high resolution spectra we derived the fundamental stellar parameters of rho Oph A and further constrained its age. We conclude that rho Oph A provides strong evidence for the presence of active X-ray emitting regions on young magnetized early type stars.
To purchase or not?
(2017)
Although ecologically and socially responsible consumption helps to reduce the harmful effects of resource use for both nature and society, all types of consumption (whether green or fair) deplete valuable resources. At the same time, to maintain household financial sustainability, spending should not exceed a household's financial resources. Thus, economically sustainable consumption is related to the consumer's decision to not buy products and the disposition to forgo specific purchases. Based on a means-end chain approach, this study investigates consumer cognitive decision-making structures related to six distinct options for economically (non-)sustainable consumption. Whereas saving motives, waste concerns, and avoidance motivations support economically sustainable decisions, economically non-sustainable decision-making is directly linked to attaining overall life goals. By clustering respondents based on the elicited means-end chains, the study discloses four consumer groups with distinctive motivational structures. The study also reveals several obstacles to promoting economic sustainability, indicates methods to overcome such obstacles, and suggests avenues for future research.
Battle of plates
(2017)
Objective: Approach-avoidance training (AAT) is a promising approach in obesity treatment. The present study examines whether an AAT is feasible and able to influence approach tendencies in children and adolescents, comparing implicit and explicit training approaches. Design/Setting/Subjects: Fifty-nine overweight children and adolescents (aged 8-16 years; twenty-six boys) participated in an AAT for food cues, learning to reject snack items and approach vegetable items. Reaction times in the AAT and an implicit association rest (IAT) were assessed pre- and post-intervention. Results: A significant increase in the AAT compatibility scores with a large effect (eta(2) = 0.18) was found. No differences between the implicit and explicit training approaches and no change in the IAT scores were observed. Conclusions: Automatic tendencies in children can be trained, too. The implementation of AAT in the treatment of obesity might support the modification of an unhealthy nutrition behaviour pattern. Further data from randomized controlled clinical trials are needed.
Anhand von Daten der Mannheimer Risikokinderstudie, die sich mit der langfristigen Entwicklung von Kindern mit unterschiedlichen Risikobelastungen beschäftigt, wird gezeigt, wie Schutzfaktoren aufseiten des Kindes und seines familiären Umfelds im Verlauf der Entwicklung wirksam werden und zur Entstehung von Resilienz beitragen können. Eine besondere Rolle kommt dabei positiven frühen Eltern-Kind-Beziehungen zu (sowohl Mutter- als auch Vater-Kind-Interaktionen). Daneben spielen auch Interaktionserfahrungen im Alter von zwei Jahren des Kindes eine bedeutsame Rolle; diese schützen Risikokinder davor, eine ungünstige Entwicklung zu nehmen und tragen dazu bei, dass sich Kinder, die in psychosozialen Hochrisikofamilien aufwachsen, trotz ungünstiger „Startbedingungen“ positiv entwickeln. Neben Merkmalen der sozialen Umwelt nehmen auch sprachliche, sozial-emotionale und internale Kompetenzen des Kindes im Entwicklungsverlauf eine wichtige Rolle ein. Diese Kompetenzen ermöglichen es Risikokindern auch unter widrigen Lebensumständen (psychosoziale Hochrisikofamilien, Aufwachsen in Armutsverhältnissen) erfolgreich zu bestehen. Darüber hinaus zeigt die Arbeit, dass Resilienz ein Persönlichkeitsmerkmal ist, das ab dem frühen Erwachsenenalter eine hohe Stabilität besitzt. Mit diesen Befunden verweist die Arbeit auf die große Bedeutung der Resilienz bei der Vorhersage der langfristigen Entwicklung von Risikokindern.
For an arbitrary euclidean field F we introduce a central extension (G(F), Phi) of SL(2, F) admitting a left-ordering and study its algebraic properties. The elements of G(F) are order preserving bijections of the convex hull of Q in F. If F = R then G(F) is isomorphic to the classical universal covering group of the Lie group SL(2, R). Among other results we show that G(F) is a perfect group which possesses a rank 1 cone of exceptional type. We also prove that its centre is an infinite cyclic group and investigate its normal subgroups.
DPP4 inhibition prevents AKI
(2017)