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Abdalla, Hassan E. ; Adam, R. ; Aharonian, Felix A. ; Benkhali, F. Ait ; Angüner, Ekrem Oǧuzhan ; Arakawa, M. ; Arcaro, C. ; Armand, C. ; Ashkar, H. ; Backes, M. ; Martins, V. Barbosa ; Barnard, M. ; Becherini, Y. ; Berge, D. ; Bernloehr, K. ; Bissaldi, E. ; Blackwell, R. ; Boettcher, M. ; Boisson, C. ; Bolmont, J. ; Bonnefoy, S. ; Bregeon, J. ; Breuhaus, M. ; Brun, F. ; Brun, P. ; Bryan, M. ; Buechele, M. ; Bulik, T. ; Bylund, T. ; Capasso, M. ; Caroff, S. ; Carosi, A. ; Casanova, Sabrina ; Cerruti, M. ; Chand, T. ; Chandra, S. ; Chen, A. ; Colafrancesco, S. ; Curylo, M. ; Davids, I. D. ; Deil, C. ; Devin, J. ; deWilt, P. ; Dirson, L. ; Djannati-Atai, A. ; Dmytriiev, A. ; Donath, A. ; Doroshenko, V ; Dyks, J. ; Egberts, Kathrin ; Emery, G. ; Ernenwein, J-P ; Eschbach, S. ; Feijen, K. ; Fegan, S. ; Fiasson, A. ; Fontaine, G. ; Funk, S. ; Fussling, Matthias ; Gabici, S. ; Gallant, Y. A. ; Gate, F. ; Giavitto, G. ; Giunti, L. ; Glawion, D. ; Glicenstein, J. F. ; Gottschall, D. ; Grondin, M-H ; Hahn, J. ; Haupt, M. ; Heinzelmann, G. ; Henri, G. ; Hermann, G. ; Hinton, J. A. ; Hofmann, W. ; Hoischen, Clemens ; Holch, T. L. ; Holler, M. ; Horns, D. ; Huber, D. ; Iwasaki, H. ; Jamrozy, M. ; Jankowsky, D. ; Jankowsky, F. ; Jardin-Blicq, A. ; Jung-Richardt, I ; Kastendieck, M. A. ; Katarzynski, K. ; Katsuragawa, M. ; Katz, U. ; Khangulyan, D. ; Khelifi, B. ; King, J. ; Klepser, S. ; Kluzniak, W. ; Komin, Nu ; Kosack, K. ; Kostunin, D. ; Kreter, M. ; Lamanna, G. ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J-P ; Leser, Eva ; Levy, C. ; Lohse, T. ; Lypova, I ; Mackey, J. ; Majumdar, J. ; Malyshev, D. ; Marandon, V ; Marcowith, Alexandre ; Mares, A. ; Mariaud, C. ; Marti-Devesa, G. ; Marx, R. ; Maurin, G. ; Meintjes, P. J. ; Mitchell, A. M. W. ; Moderski, R. ; Mohamed, M. ; Mohrmann, L. ; Moore, C. ; Moulin, Emmanuel ; Muller, J. ; Murach, T. ; Nakashima, S. ; de Naurois, M. ; Ndiyavala, H. ; Niederwanger, F. ; Niemiec, J. ; Oakes, L. ; Odaka, H. ; Ohm, S. ; Wilhelmi, E. de Ona ; Ostrowski, M. ; Oya, I ; Panter, M. ; Parsons, R. D. ; Perennes, C. ; Petrucci, P-O ; Peyaud, B. ; Piel, Q. ; Pita, S. ; Poireau, V ; Noel, A. Priyana ; Prokhorov, D. A. ; Prokoph, H. ; Puehlhofer, G. ; Punch, M. ; Quirrenbach, A. ; Raab, S. ; Rauth, R. ; Reimer, A. ; Reimer, O. ; Remy, Q. ; Renaud, M. ; Rieger, F. ; Rinchiuso, L. ; Romoli, C. ; Rowell, G. ; Rudak, B. ; Ruiz-Velasco, E. ; Sahakian, V ; Sailer, S. ; Saito, S. ; Sanchez, D. A. ; Santangelo, Andrea ; Sasaki, M. ; Schlickeiser, R. ; Schussler, F. ; Schulz, A. ; Schutte, H. M. ; Schwanke, U. ; Schwemmer, S. ; Seglar-Arroyo, M. ; Senniappan, M. ; Seyffert, A. S. ; Shafi, N. ; Shiningayamwe, K. ; Simoni, R. ; Sinha, A. ; Sol, H. ; Specovius, A. ; Spir-Jacob, M. ; Stawarz, L. ; Steenkamp, R. ; Stegmann, Christian ; Steppa, Constantin Beverly ; Takahashi, T. ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tiziani, D. ; Tluczykont, M. ; Trichard, C. ; Tsirou, M. ; Tsuji, N. ; Tuffs, R. ; Uchiyama, Y. ; van der Walt, D. J. ; van Eldik, C. ; van Rensburg, C. ; van Soelen, B. ; Vasileiadis, G. ; Veh, J. ; Venter, C. ; Vincent, P. ; Vink, J. ; Voelk, H. J. ; Vuillaume, T. ; Wadiasingh, Z. ; Wagner, S. J. ; White, R. ; Wierzcholska, A. ; Yang, R. ; Yoneda, H. ; Zacharias, M. ; Zanin, R. ; Zdziarski, A. A. ; Zech, Alraune ; Ziegler, A. ; Zorn, J. ; Zywucka, N. ; de Palma, F. ; Axelsson, M. ; Roberts, O. J.
Gamma-ray bursts (GRBs) are brief flashes of gamma-rays and are considered to be the most energetic explosive phenomena in the Universe(1). The emission from GRBs comprises a short (typically tens of seconds) and bright prompt emission, followed by a much longer afterglow phase. During the afterglow phase, the shocked outflow-produced by the interaction between the ejected matter and the circumburst medium-slows down, and a gradual decrease in brightness is observed(2). GRBs typically emit most of their energy via.-rays with energies in the kiloelectronvolt-to-megaelectronvolt range, but a few photons with energies of tens of gigaelectronvolts have been detected by space-based instruments(3). However, the origins of such high-energy (above one gigaelectronvolt) photons and the presence of very-high-energy (more than 100 gigaelectronvolts) emission have remained elusive(4). Here we report observations of very-high-energy emission in the bright GRB 180720B deep in the GRB afterglow-ten hours after the end of the prompt emission phase, when the X-ray flux had already decayed by four orders of magnitude. Two possible explanations exist for the observed radiation: inverse Compton emission and synchrotron emission of ultrarelativistic electrons. Our observations show that the energy fluxes in the X-ray and gamma-ray range and their photon indices remain comparable to each other throughout the afterglow. This discovery places distinct constraints on the GRB environment for both emission mechanisms, with the inverse Compton explanation alleviating the particle energy requirements for the emission observed at late times. The late timing of this detection has consequences for the future observations of GRBs at the highest energies.
Abdalla, Hassan E. ; Adam, R. ; Aharonian, Felix A. ; Benkhali, F. Ait ; Angüner, Ekrem Oǧuzhan ; Arakawa, M. ; Arcaro, C. ; Armand, C. ; Ashkar, H. ; Backes, M. ; Martins, V. Barbosa ; Barnard, M. ; Becherini, Y. ; Berge, D. ; Bernloehr, K. ; Blackwell, R. ; Böttcher, M. ; Boisson, C. ; Bolmont, J. ; Bonnefoy, S. ; Bregeon, J. ; Breuhaus, M. ; Brun, F. ; Brun, P. ; Bryan, M. ; Büchele, M. ; Bulik, T. ; Bylund, T. ; Capasso, M. ; Caroff, S. ; Carosi, A. ; Casanova, Sabrina ; Cerruti, M. ; Chand, T. ; Chandra, S. ; Chen, A. ; Colafrancesco, S. ; Curylo, M. ; Davids, I. D. ; Deil, C. ; Devin, J. ; DeWilt, P. ; Dirson, L. ; Djannati-Ata, A. ; Dmytriiev, A. ; Donath, A. ; Doroshenko, V ; Dyks, J. ; Egberts, Kathrin ; Emery, G. ; Ernenwein, J-P ; Eschbach, S. ; Feijen, K. ; Fegan, S. ; Fiasson, A. ; Fontaine, G. ; Funk, S. ; Füßling, Matthias ; Gabici, S. ; Gallant, Y. A. ; Gate, F. ; Giavitto, G. ; Glawion, D. ; Glicenstein, J. F. ; Gottschall, D. ; Grondin, M-H ; Hahn, J. ; Haupt, M. ; Heinzelmann, G. ; Henri, G. ; Hermann, G. ; Hinton, James Anthony ; Hofmann, W. ; Hoischen, Clemens ; Holch, Tim Lukas ; Holler, M. ; Horns, D. ; Huber, D. ; Iwasaki, H. ; Jamrozy, M. ; Jankowsky, D. ; Jankowsky, F. ; Jardin-Blicq, A. ; Jung-Richardt, I ; Kastendieck, M. A. ; Katarzynski, K. ; Katsuragawa, M. ; Katz, U. ; Khangulyan, D. ; Khelifi, B. ; King, J. ; Klepser, S. ; Kluzniak, W. ; Komin, Nu ; Kosack, K. ; Kostunin, D. ; Kraus, M. ; Lamanna, G. ; Lau, J. ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J-P ; Leser, Eva ; Levy, C. ; Lohse, T. ; Lypova, I ; Mackey, J. ; Majumdar, J. ; Malyshev, D. ; Marandon, V ; Marcowith, Alexandre ; Mares, A. ; Mariaud, C. ; Marti-Devesa, G. ; Marx, R. ; Maurin, G. ; Meintjes, P. J. ; Mitchell, A. M. W. ; Moderski, R. ; Mohamed, M. ; Mohrmann, L. ; Moore, C. ; Moulin, Emmanuel ; Muller, J. ; Murach, T. ; Nakashima, S. ; de Naurois, M. ; Ndiyavala, H. ; Niederwanger, F. ; Niemiec, J. ; Oakes, L. ; Odaka, H. ; Ohm, S. ; Wilhelmi, E. de Ona ; Ostrowski, M. ; Oya, I ; Panter, M. ; Parsons, R. D. ; Perennes, C. ; Petrucci, P-O ; Peyaud, B. ; Piel, Q. ; Pita, S. ; Poireau, V ; Priyana Noel, A. ; Prokhorov, D. A. ; Prokoph, H. ; Pühlhofer, G. ; Punch, M. ; Quirrenbach, A. ; Raab, S. ; Rauth, R. ; Reimer, A. ; Reimer, O. ; Remy, Q. ; Renaud, M. ; Rieger, F. ; Rinchiuso, L. ; Romoli, C. ; Rowell, G. ; Rudak, B. ; Ruiz-Velasco, E. ; Sahakian, V ; Saito, S. ; Sanchez, David M. ; Santangelo, Andrea ; Sasaki, M. ; Schlickeiser, R. ; Schüssler, F. ; Schulz, A. ; Schutte, H. ; Schwanke, U. ; Schwemmer, S. ; Seglar-Arroyo, M. ; Senniappan, M. ; Seyffert, A. S. ; Shafi, N. ; Shiningayamwe, K. ; Simoni, R. ; Sinha, A. ; Sol, H. ; Specovius, A. ; Spir-Jacob, M. ; Stawarz, L. ; Steenkamp, R. ; Stegmann, Christian ; Steppa, Constantin Beverly ; Takahashi, T. ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tiziani, D. ; Tluczykont, M. ; Trichard, C. ; Tsirou, M. ; Tsuji, N. ; Tuffs, R. ; Uchiyama, Y. ; van Der Walt, D. J. ; van Eldik, C. ; van Rensburg, C. ; van Soelen, B. ; Vasileiadis, G. ; Veh, J. ; Venter, C. ; Vincent, P. ; Vink, J. ; Voisin, F. ; Voelk, H. J. ; Vuillaume, T. ; Wadiasingh, Z. ; Wagner, S. J. ; White, R. ; Wierzcholska, A. ; Yang, R. ; Yoneda, H. ; Zacharias, Michael ; Zanin, R. ; Zdziarski, A. A. ; Zech, Alraune ; Ziegler, A. ; Zorn, J. ; Zywucka, N. ; Meyer, M.
The flat spectrum radio quasar 3C 279 is known to exhibit pronounced variability in the high-energy (100MeV < E < 100 GeV) gamma-ray band, which is continuously monitored with Fermi-LAT. During two periods of high activity in April 2014 and June 2015 target-of-opportunity observations were undertaken with the High Energy Stereoscopic System (H.E.S.S.) in the very-high-energy (VHE, E > 100 GeV) gamma-ray domain. While the observation in 2014 provides an upper limit, the observation in 2015 results in a signal with 8 : 7 sigma significance above an energy threshold of 66 GeV. No VHE variability was detected during the 2015 observations. The VHE photon spectrum is soft and described by a power-law index of 4.2 +/- 0.3. The H.E.S.S. data along with a detailed and contemporaneous multiwavelength data set provide constraints on the physical parameters of the emission region. The minimum distance of the emission region from the central black hole was estimated using two plausible geometries of the broad-line region and three potential intrinsic spectra. The emission region is confidently placed at r greater than or similar to 1 : 7 X 1017 cm from the black hole, that is beyond the assumed distance of the broad-line region. Time-dependent leptonic and lepto-hadronic one-zone models were used to describe the evolution of the 2015 flare. Neither model can fully reproduce the observations, despite testing various parameter sets. Furthermore, the H.E.S.S. data were used to derive constraints on Lorentz invariance violation given the large redshift of 3C 279.
Abdalla, Hassan E. ; Aharonian, Felix A. ; Benkhali, F. Ait ; Anguener, E. O. ; Arakawa, M. ; Arcaro, C. ; Armand, C. ; Ashkar, H. ; Backes, M. ; Martins, V. Barbosa ; Barnard, M. ; Becherini, Y. ; Berge, D. ; Bernloehr, K. ; Blackwell, R. ; Boettcher, M. ; Boisson, C. ; Bolmont, J. ; Bonnefoy, S. ; Bregeon, J. ; Breuhaus, M. ; Brun, F. ; Brun, P. ; Bryan, M. ; Buechele, M. ; Bulik, T. ; Bylund, T. ; Capasso, M. ; Caroff, S. ; Carosi, A. ; Casanova, Sabrina ; Cerruti, M. ; Chakraborty, N. ; Chand, T. ; Chandra, S. ; Chaves, R. C. G. ; Chen, A. ; Colafrancesco, S. ; Curylo, M. ; Davids, I. D. ; Deil, C. ; Devin, J. ; de Wilt, P. ; Dirson, L. ; Djannati-Atai, A. ; Dmytriiev, A. ; Donath, A. ; Doroshenko, V ; Dyks, J. ; Egberts, Kathrin ; Emery, G. ; Ernenwein, J-p ; Eschbach, S. ; Feijen, K. ; Fegan, S. ; Fiasson, A. ; Fontaine, G. ; Funk, S. ; Fuessling, M. ; Gabici, S. ; Gallant, Y. A. ; Gate, F. ; Giavitto, G. ; Glawion, D. ; Glicenstein, J. F. ; Gottschall, D. ; Grondin, M-H ; Hahn, J. ; Haupt, M. ; Heinzelmann, G. ; Henri, G. ; Hermann, G. ; Hinton, James Anthony ; Hofmann, W. ; Hoischen, Clemens ; Holch, Tim Lukas ; Holler, M. ; Horns, D. ; Huber, D. ; Iwasaki, H. ; Jamrozy, M. ; Jankowsky, D. ; Jankowsky, F. ; Jung-Richardt, I ; Kastendieck, M. A. ; Katarzynski, K. ; Katsuragawa, M. ; Katz, U. ; Khangulyan, D. ; Khelifi, B. ; King, J. ; Klepser, S. ; Kluzniak, W. ; Komin, Nu ; Kosack, K. ; Kostunin, D. ; Kraus, M. ; Lamanna, G. ; Lau, J. ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J-P ; Leser, Eva ; Levy, C. ; Lohse, T. ; Lopez-Coto, R. ; Lypova, I ; Mackey, J. ; Majumdar, J. ; Malyshev, D. ; Marandon, V ; Marcowith, Alexandre ; Mares, A. ; Mariaud, C. ; Marti-Devesa, G. ; Marx, R. ; Maurin, G. ; Meintjes, P. J. ; Mitchell, A. M. W. ; Moderski, R. ; Mohamed, M. ; Mohrmann, L. ; Muller, J. ; Moore, C. ; Moulin, Emmanuel ; Murach, T. ; Nakashima, S. ; de Naurois, M. ; Ndiyavala, H. ; Niederwanger, F. ; Niemiec, J. ; Oakes, L. ; Odaka, H. ; Ohm, S. ; Wilhelmi, E. de Ona ; Ostrowski, M. ; Oya, I ; Panter, M. ; Parsons, R. D. ; Perennes, C. ; Petrucci, P-O ; Peyaud, B. ; Piel, Q. ; Pita, S. ; Poireau, V ; Noel, A. Priyana ; Prokhorov, D. A. ; Prokoph, H. ; Puehlhofer, G. ; Punch, M. ; Quirrenbach, A. ; Raab, S. ; Rauth, R. ; Reimer, A. ; Reimer, O. ; Remy, Q. ; Renaud, M. ; Rieger, F. ; Rinchiuso, L. ; Romoli, C. ; Rowell, G. ; Rudak, B. ; Ruiz-Velasco, E. ; Sahakian, V ; Saito, S. ; Sanchez, David M. ; Santangelo, Andrea ; Sasaki, M. ; Schlickeiser, R. ; Schussler, F. ; Schulz, A. ; Schutte, H. ; Schwanke, U. ; Schwemmer, S. ; Seglar-Arroyo, M. ; Senniappan, M. ; Seyffert, A. S. ; Shafi, N. ; Shiningayamwe, K. ; Simoni, R. ; Sinha, A. ; Sol, H. ; Specovius, A. ; Spir-Jacob, M. ; Stawarz, L. ; Steenkamp, R. ; Stegmann, Christian ; Steppa, Constantin Beverly ; Takahashi, T. ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tiziani, D. ; Tluczykont, M. ; Trichard, C. ; Tsirou, M. ; Tsuji, N. ; Tuffs, R. ; Uchiyama, Y. ; van der Walt, D. J. ; van Eldik, C. ; van Rensburg, C. ; van Soelen, B. ; Vasileiadis, G. ; Veh, J. ; Venter, C. ; Vincent, P. ; Vink, J. ; Voisin, F. ; Voelk, H. J. ; Vuillaume, T. ; Wadiasingh, Z. ; Wagner, S. J. ; White, R. ; Wierzcholska, A. ; Yang, R. ; Yoneda, H. ; Zacharias, M. ; Zanin, R. ; Zdziarski, A. A. ; Zech, Alraune ; Ziegler, A. ; Zorn, J. ; Zywucka, N. ; Maxted, N.
Young core-collapse supernovae with dense-wind progenitors may be able to accelerate cosmic-ray hadrons beyond the knee of the cosmic-ray spectrum, and this may result in measurable gamma-ray emission. We searched for gamma-ray emission from ten super- novae observed with the High Energy Stereoscopic System (H.E.S.S.) within a year of the supernova event. Nine supernovae were observed serendipitously in the H.E.S.S. data collected between December 2003 and December 2014, with exposure times ranging from 1.4 to 53 h. In addition we observed SN 2016adj as a target of opportunity in February 2016 for 13 h. No significant gamma-ray emission has been detected for any of the objects, and upper limits on the >1 TeV gamma-ray flux of the order of similar to 10(-13) cm(-)(2)s(-1) are established, corresponding to upper limits on the luminosities in the range similar to 2 x 10(39) to similar to 1 x 10(42) erg s(-1). These values are used to place model-dependent constraints on the mass-loss rates of the progenitor stars, implying upper limits between similar to 2 x 10(-5) and similar to 2 x 10(-3) M-circle dot yr(-1) under reasonable assumptions on the particle acceleration parameters.
Abdalla, Hassan E. ; Aharonian, Felix A. ; Benkhali, F. Ait ; Angüner, Ekrem Oǧuzhan ; Arakawa, M. ; Arcaro, C. ; Armand, C. ; Arrieta, M. ; Backes, M. ; Barnard, M. ; Becherini, Y. ; Tjus, J. Becker ; Berge, D. ; Bernhard, S. ; Bernloehr, K. ; Blackwell, R. ; Bottcher, M. ; Boisson, C. ; Bolmont, J. ; Bonnefoy, S. ; Bordas, Pol ; Bregeon, J. ; Brun, F. ; Brun, P. ; Bryan, M. ; Buechele, M. ; Bulik, T. ; Bylund, T. ; Capasso, M. ; Caroff, S. ; Carosi, A. ; Cerruti, M. ; Chakraborty, N. ; Chandra, S. ; Chaves, R. C. G. ; Chen, A. ; Colafrancesco, S. ; Condon, B. ; Davids, I. D. ; Deil, C. ; Devin, J. ; deWilt, P. ; Dirson, L. ; Djannati-Atai, A. ; Dmytriiev, A. ; Donath, A. ; Doroshenko, V ; Dyks, J. ; Egberts, Kathrin ; Emery, G. ; Ernenwein, J-P ; Eschbach, S. ; Fegan, S. ; Fiasson, A. ; Fontaine, G. ; Funk, S. ; Fuessling, M. ; Gabici, S. ; Gallant, Y. A. ; Gate, F. ; Giavitto, G. ; Glawion, D. ; Glicenstein, J. F. ; Gottschall, D. ; Grondin, M-H ; Hahn, J. ; Haupt, M. ; Heinzelmann, G. ; Henri, G. ; Hermann, G. ; Hinton, James Anthony ; Hofmann, W. ; Hoischen, Clemens ; Holch, Tim Lukas ; Holler, M. ; Horns, D. ; Huber, D. ; Iwasaki, H. ; Jacholkowska, A. ; Jamrozy, M. ; Jankowsky, D. ; Jankowsky, F. ; Jouvin, L. ; Jung-Richardt, I ; Kastendieck, M. A. ; Katarzynski, K. ; Katsuragawa, M. ; Katz, U. ; Kerszberg, D. ; Khangulyan, D. ; Khelifi, B. ; King, J. ; Klepser, S. ; Kluzniak, W. ; Komin, Nu ; Kosack, K. ; Krakau, S. ; Kraus, M. ; Kruger, P. P. ; Lamanna, G. ; Lau, J. ; Lefaucheur, J. ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J-P ; Leser, Eva ; Lohse, T. ; Lorentz, M. ; Lopez-Coto, R. ; Lypova, I ; Malyshev, D. ; Marandon, V ; Marcowith, Alexandre ; Mariaud, C. ; Marti-Devesa, G. ; Marx, R. ; Maurin, G. ; Meintjes, P. J. ; Mitchell, A. M. W. ; Moderski, R. ; Mohamed, M. ; Mohrmann, L. ; Moulin, Emmanuel ; Murach, T. ; Nakashima, S. ; de Naurois, M. ; Ndiyavala, H. ; Niederwanger, F. ; Niemiec, J. ; Oakes, L. ; Odaka, H. ; Ohm, S. ; Ostrowski, M. ; Oya, I ; Padovani, M. ; Panter, M. ; Parsons, R. D. ; Perennes, C. ; Petrucci, P-O ; Peyaud, B. ; Piel, Q. ; Pita, S. ; Poireau, V ; Noel, A. Priyana ; Prokhorov, D. ; Prokoph, H. ; Puehlhofer, G. ; Punch, M. ; Quirrenbach, A. ; Raab, S. ; Rauth, R. ; Reimer, A. ; Reimer, O. ; Renaud, M. ; Rieger, F. ; Rinchiuso, L. ; Romoli, C. ; Rowell, G. ; Rudak, B. ; Ruiz-Velasco, E. ; Sahakian, V ; Saito, S. ; Sanchez, David M. ; Santangelo, Andrea ; Sasaki, M. ; Schlickeiser, R. ; Schussler, F. ; Schulz, A. ; Schwanke, U. ; Schwemmer, S. ; Seglar-Arroyo, M. ; Senniappan, M. ; Seyffert, A. S. ; Shafi, N. ; Shilon, I ; Shiningayamwe, K. ; Simoni, R. ; Sinha, A. ; Sol, H. ; Spanier, F. ; Specovius, A. ; Spir-Jacob, M. ; Stawarz, L. ; Steenkamp, R. ; Stegmann, Christian ; Steppa, Constantin Beverly ; Takahashi, T. ; Tavernet, J-P ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tibaldo, L. ; Tiziani, D. ; Tluczykont, M. ; Trichard, C. ; Tsirou, M. ; Tsuji, N. ; Tuffs, R. ; Uchiyama, Y. ; van der Walt, D. J. ; van Eldik, C. ; van Rensburg, C. ; van Soelen, B. ; Vasileiadis, G. ; Veh, J. ; Venter, C. ; Vincent, P. ; Vink, J. ; Voisin, F. ; Voelk, H. J. ; Vuillaume, T. ; Wadiasingh, Z. ; Wagner, S. J. ; Wagner, R. M. ; White, R. ; Wierzcholska, A. ; Yang, R. ; Zaborov, D. ; Zacharias, M. ; Zanin, R. ; Zdziarski, A. A. ; Zech, Alraune ; Zefi, F. ; Ziegler, A. ; Zorn, J. ; Zywucka, N.
The blazar Mrk 501 (z = 0.034) was observed at very-high-energy (VHE, E greater than or similar to 100 GeV) gamma-ray wavelengths during a bright flare on the night of 2014 June 23-24 (MJD 56832) with the H.E.S.S. phase-II array of Cherenkov telescopes. Data taken that night by H.E.S.S. at large zenith angle reveal an exceptional number of gamma-ray photons at multi-TeV energies, with rapid flux variability and an energy coverage extending significantly up to 20 TeV. This data set is used to constrain Lorentz invariance violation (LIV) using two independent channels: a temporal approach considers the possibility of an energy dependence in the arrival time of gamma-rays, whereas a spectral approach considers the possibility of modifications to the interaction of VHE gamma-rays with extragalactic background light (EBL) photons. The non-detection of energy-dependent time delays and the non-observation of deviations between the measured spectrum and that of a supposed power-law intrinsic spectrum with standard EBL attenuation are used independently to derive strong constraints on the energy scale of LIV (E-QG) in the subluminal scenario for linear and quadratic perturbations in the dispersion relation of photons. For the case of linear perturbations, the 95% confidence level limits obtained are E-QG,E-1 > 3.6 x 10(17) GeV using the temporal approach and E-QG,E-1 > 2.6 x 10(19) GeV using the spectral approach. For the case of quadratic perturbations, the limits obtained are E-QG,E-2 > 8.5 x 10(10) GeV using the temporal approach and E-QG,E-2 > 7.8 x 10(11) GeV using the spectral approach.
Abdalla, Hassan E. ; Aharonian, Felix A. ; Benkhali, F. Ait ; Angüner, Ekrem Oǧuzhan ; Arakawa, M. ; Arcaro, C. ; Armand, C. ; Arrieta, M. ; Backes, M. ; Barnard, M. ; Becherini, Y. ; Tjus, J. Becker ; Berge, D. ; Bernloehr, K. ; Blackwell, R. ; Bottcher, M. ; Boisson, C. ; Bolmont, J. ; Bonnefoy, S. ; Bordas, Pol ; Bregeon, J. ; Brun, F. ; Brun, P. ; Bryan, M. ; Buchele, M. ; Bulik, T. ; Bylund, T. ; Capasso, M. ; Caroff, S. ; Carosi, A. ; Casanova, Sabrina ; Cerruti, M. ; Chakraborty, N. ; Chand, T. ; Chandra, S. ; Chaves, R. C. G. ; Chen, A. ; Colafrancesco, S. ; Condon, B. ; Davids, I. D. ; Deil, C. ; Devin, J. ; deWilt, P. ; Dirson, L. ; Djannati-Atai, A. ; Dmytriiev, A. ; Donath, A. ; Doroshenko, V. ; Dyks, J. ; Egberts, Kathrin ; Emery, G. ; Ernenwein, J. -P. ; Eschbach, S. ; Fegan, S. ; Fiasson, A. ; Fontaine, G. ; Funk, S. ; Fuessling, M. ; Gabici, S. ; Gallant, Y. A. ; Gate, F. ; Giavitto, G. ; Glawion, D. ; Glicenstein, J. F. ; Gottschall, D. ; Grondin, M. -H. ; Hahn, J. ; Haupt, M. ; Heinzelmann, G. ; Henri, G. ; Hermann, G. ; Hinton, James Anthony ; Hofmann, W. ; Hoischen, Clemens ; Holch, Tim Lukas ; Holler, M. ; Horns, D. ; Huber, D. ; Iwasaki, H. ; Jacholkowska, A. ; Jamrozy, M. ; Jankowsky, D. ; Jankowsky, F. ; Jouvin, L. ; Jung-Richardt, I. ; Kastendieck, M. A. ; Katarzynski, K. ; Katsuragawa, M. ; Katz, U. ; Khangulyan, D. ; Khelifi, B. ; King, J. ; Klepser, S. ; Kluzniak, W. ; Komin, Nu. ; Kosack, K. ; Kraus, M. ; Lamanna, G. ; Lau, J. ; Lefaucheur, J. ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J. -P. ; Leser, Eva ; Lohse, T. ; Lopez-Coto, R. ; Lorentz, M. ; Lypova, I. ; Malyshev, D. ; Marandon, V. ; Marcowith, Alexandre ; Mariaud, C. ; Marti-Devesa, G. ; Marx, R. ; Maurin, G. ; Meintjes, P. J. ; Mitchell, A. M. W. ; Moderski, R. ; Mohamed, M. ; Mohrmann, L. ; Moore, C. ; Moulin, Emmanuel ; Murach, T. ; Nakashima, S. ; de Naurois, M. ; Ndiyavala, H. ; Niederwanger, F. ; Niemiec, J. ; Oakes, L. ; Odaka, H. ; Ohm, S. ; Ostrowski, M. ; Oya, I. ; Panter, M. ; Parsons, R. D. ; Perennes, C. ; Petrucci, P. -O. ; Peyaud, B. ; Piel, Q. ; Pita, S. ; Poireau, V. ; Noel, A. Priyana ; Prokhorov, D. A. ; Prokoph, H. ; Puehlhofer, G. ; Punch, M. ; Quirrenbach, A. ; Raab, S. ; Rauth, R. ; Reimer, A. ; Reimer, O. ; Renaud, M. ; Rieger, F. ; Rinchiuso, L. ; Romoli, C. ; Rowell, G. ; Rudak, B. ; Ruiz-Velasco, E. ; Sahakian, V. ; Saito, S. ; Sanchez, David M. ; Santangelo, Andrea ; Sasaki, M. ; Schlickeiser, R. ; Schussler, F. ; Schulz, A. ; Schutte, H. ; Schwanke, U. ; Schwemmer, S. ; Seglar-Arroyo, M. ; Senniappan, M. ; Seyffert, A. S. ; Shafi, N. ; Shilon, I. ; Shiningayamwe, K. ; Simoni, R. ; Sinha, A. ; Sol, H. ; Specovius, A. ; Spir-Jacob, M. ; Stawarz, L. ; Steenkamp, R. ; Stegmann, Christian ; Steppa, Constantin Beverly ; Takahashi, T. ; Tavernet, J. -P. ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tiziani, D. ; Tluczykont, M. ; Trichard, C. ; Tsirou, M. ; Tsuji, N. ; Tuffs, R. ; Uchiyama, Y. ; van der Walt, D. J. ; van Eldik, C. ; van Rensburg, C. ; van Soelen, B. ; Vasileiadis, G. ; Veh, J. ; Venter, C. ; Vincent, P. ; Vink, J. ; Voisin, F. ; Voelk, H. J. ; Vuillaume, T. ; Wadiasingh, Z. ; Wagner, S. J. ; Wagner, R. M. ; White, R. ; Wierzcholska, A. ; Yang, R. ; Yoneda, H. ; Zaborov, D. ; Zacharias, M. ; Zanin, R. ; Zdziarski, A. A. ; Zech, Alraune ; Ziegler, A. ; Zorn, J. ; Zywucka, N.
PKS 1830-211 is a known macrolensed quasar located at a redshift of z = 2.5. Its highenergy gamma-ray emission has been detected with the Fermi-Large Area Telescope (LAT) instrument and evidence for lensing was obtained by several authors from its high-energy data. Observations of PKS 1830-211 were taken with the High Energy Stereoscopic System (H.E.S.S.) array of Imaging Atmospheric Cherenkov Telescopes in 2014 August, following a flare alert by the Fermi-LAT Collaboration. The H.E.S.S observations were aimed at detecting a gamma-ray flare delayed by 20-27 d from the alert flare, as expected from observations at other wavelengths. More than 12 h of good-quality data were taken with an analysis threshold of similar to 67 GeV. The significance of a potential signal is computed as a function of the date and the average significance over the whole period. Data are compared to simultaneous observations by Fermi-LAT. No photon excess or significant signal is detected. An upper limit on PKS 1830-211 flux above 67 GeV is computed and compared to the extrapolation of the Fermi-LAT flare spectrum.
Abdalla, Hassan E. ; Aharonian, Felix A. ; Benkhali, F. Ait ; Angüner, Ekrem Oǧuzhan ; Arakawa, M. ; Arcaro, C. ; Armand, C. ; Arrieta, M. ; Backes, M. ; Barnard, M. ; Becherini, Y. ; Tjus, J. Becker ; Berge, D. ; Bernloehr, K. ; Blackwell, R. ; Bottcher, M. ; Boisson, C. ; Bolmont, J. ; Bonnefoy, S. ; Bordas, Pol ; Bregeon, J. ; Brun, F. ; Brun, P. ; Bryan, M. ; Buechele, M. ; Bulik, T. ; Bylund, T. ; Capasso, M. ; Caroff, S. ; Carosi, A. ; Casanova, Sabrina ; Cerruti, M. ; Chakraborty, N. ; Chand, T. ; Chandra, S. ; Chaves, R. C. G. ; Chen, A. ; Colafrancesco, S. ; Condon, B. ; Davids, I. D. ; Deil, C. ; Devin, J. ; deWilt, P. ; Dirson, L. ; Djannati-Atai, A. ; Dmytriiev, A. ; Donath, A. ; Doroshenko, V ; Dyks, J. ; Egberts, Kathrin ; Emery, G. ; Ernenwein, J-P ; Eschbach, S. ; Fegan, S. ; Fiasson, A. ; Fontaine, G. ; Funk, S. ; Fuessling, M. ; Gabici, S. ; Gallant, Y. A. ; Gate, F. ; Giavitto, G. ; Glawion, D. ; Glicenstein, J. F. ; Gottschall, D. ; Grondin, M-H ; Hahn, J. ; Haupt, M. ; Heinzelmann, G. ; Henri, G. ; Hermann, G. ; Hinton, James Anthony ; Hofmann, W. ; Hoischen, Clemens ; Holch, Tim Lukas ; Holler, M. ; Horns, D. ; Huber, D. ; Iwasaki, H. ; Jacholkowska, A. ; Jamrozy, M. ; Jankowsky, D. ; Jankowsky, F. ; Jouvin, L. ; Jung-Richardt, I ; Kastendieck, M. A. ; Katarzynski, K. ; Katsuragawa, M. ; Katz, U. ; Kerszberg, D. ; Khangulyan, D. ; Khelifi, B. ; King, J. ; Klepser, S. ; Kluzniak, W. ; Komin, Nu ; Kosack, K. ; Kraus, M. ; Lamanna, G. ; Lau, J. ; Lefaucheur, J. ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J-P ; Leser, Eva ; Lohse, T. ; Lopez-Coto, R. ; Lypova, I ; Malyshev, D. ; Marandon, V ; Marcowith, Alexandre ; Mariaud, C. ; Marti-Devesa, G. ; Marx, R. ; Maurin, G. ; Meintjes, P. J. ; Mitchell, A. M. W. ; Moderski, R. ; Mohamed, M. ; Mohrmann, L. ; Moore, C. ; Moulin, Emmanuel ; Murach, T. ; Nakashima, S. ; de Naurois, M. ; Ndiyavala, H. ; Niederwanger, F. ; Niemiec, J. ; Oakes, L. ; Odaka, H. ; Ohm, S. ; Ostrowski, M. ; Oya, I ; Panter, M. ; Parsons, R. D. ; Perennes, C. ; Petrucci, P-O ; Peyaud, B. ; Piel, Q. ; Pita, S. ; Poireau, V ; Noel, A. Priyana ; Prokhorov, D. A. ; Prokoph, H. ; Puehlhofer, G. ; Punch, M. ; Quirrenbach, A. ; Raab, S. ; Rauth, R. ; Reimer, A. ; Reimer, O. ; Renaud, M. ; Rieger, F. ; Rinchiuso, L. ; Romoli, C. ; Rowell, G. ; Rudak, B. ; Ruiz-Velasco, E. ; Sahakian, V ; Saito, S. ; Sanchez, David M. ; Santangelo, Andrea ; Sasaki, M. ; Schlickeiser, R. ; Schussler, F. ; Schulz, A. ; Schutte, H. ; Schwanke, U. ; Schwemmer, S. ; Seglar-Arroyo, M. ; Senniappan, M. ; Seyffert, A. S. ; Shafi, N. ; Shilon, I ; Shiningayamwe, K. ; Simoni, R. ; Sinha, A. ; Sol, H. ; Specovius, A. ; Spir-Jacob, M. ; Stawarz, L. ; Steenkamp, R. ; Stegmann, Christian ; Steppa, Constantin Beverly ; Takahashi, T. ; Tavernet, J-P ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tibaldo, L. ; Tiziani, D. ; Tluczykont, M. ; Trichard, C. ; Tsirou, M. ; Tsuji, N. ; Tuffs, R. ; Uchiyama, Y. ; van der Walt, D. J. ; van Eldik, C. ; van Rensburg, C. ; van Soelen, B. ; Vasileiadis, G. ; Veh, J. ; Venter, C. ; Vincent, P. ; Vink, J. ; Voisin, F. ; Voelk, H. J. ; Vuillaume, T. ; Wadiasingh, Z. ; Wagner, S. J. ; Wagner, R. M. ; White, R. ; Wierzcholska, A. ; Yang, R. ; Yoneda, H. ; Zaborov, D. ; Zacharias, M. ; Zanin, R. ; Zdziarski, A. A. ; Zech, Alraune ; Zefi, F. ; Ziegler, A. ; Zorn, J. ; Zywucka, N.
Context. We present a detailed view of the pulsar wind nebula (PWN) HESS J1825-137. We aim to constrain the mechanisms dominating the particle transport within the nebula, accounting for its anomalously large size and spectral characteristics. Aims. The nebula was studied using a deep exposure from over 12 years of H.E.S.S. I operation, together with data from H.E.S.S. II that improve the low-energy sensitivity. Enhanced energy-dependent morphological and spatially resolved spectral analyses probe the very high energy (VHE, E > 0.1 TeV) gamma-ray properties of the nebula. Methods. The nebula emission is revealed to extend out to 1.5 degrees from the pulsar, similar to 1.5 times farther than previously seen, making HESS J1825-137, with an intrinsic diameter of similar to 100 pc, potentially the largest gamma-ray PWN currently known. Characterising the strongly energy-dependent morphology of the nebula enables us to constrain the particle transport mechanisms. A dependence of the nebula extent with energy of R proportional to E alpha with alpha = -0.29 +/- 0.04(stat) +/- 0.05(sys) disfavours a pure diffusion scenario for particle transport within the nebula. The total gamma-ray flux of the nebula above 1 TeV is found to be (1.12 +/- 0.03(stat) +/- 0.25(sys)) +/- 10(-11) cm(-2) s(-1), corresponding to similar to 64% of the flux of the Crab nebula. Results. HESS J1825-137 is a PWN with clearly energy-dependent morphology at VHE gamma-ray energies. This source is used as a laboratory to investigate particle transport within intermediate-age PWNe. Based on deep observations of this highly spatially extended PWN, we produce a spectral map of the region that provides insights into the spectral variation within the nebula.
Abdalla, Hassan E. ; Aharonian, Felix A. ; Benkhali, F. Ait ; Angüner, Ekrem Oǧuzhan ; Arakawa, M. ; Arcaro, C. ; Armand, C. ; Backes, M. ; Barnard, M. ; Becherini, Y. ; Berge, D. ; Bernloehr, K. ; Blackwell, R. ; Bottcher, M. ; Boisson, C. ; Bolmont, J. ; Bonnefoy, S. ; Bregeon, J. ; Brun, F. ; Brun, P. ; Bryan, M. ; Buechele, M. ; Bulik, T. ; Bylund, T. ; Capasso, M. ; Caroff, S. ; Carosi, A. ; Casanova, Sabrina ; Cerruti, M. ; Chakraborty, N. ; Chand, T. ; Chandra, S. ; Chaves, R. C. G. ; Chen, A. ; Colafrancesco, S. ; Condon, B. ; Davids, I. D. ; Deil, C. ; Devin, J. ; deWilt, P. ; Dirson, L. ; Djannati-Atai, A. ; Dmytriiev, A. ; Donath, A. ; Doroshenko, V ; Dyks, J. ; Egberts, Kathrin ; Emery, G. ; Ernenwein, J-P ; Eschbach, S. ; Feijen, K. ; Fegan, S. ; Fiasson, A. ; Fontaine, G. ; Funk, S. ; Fuessling, M. ; Gabici, S. ; Gallant, Y. A. ; Gate, F. ; Giavitto, G. ; Glawion, D. ; Glicenstein, J. F. ; Gottschall, D. ; Grondin, M-H ; Hahn, J. ; Haupt, M. ; Heinzelmann, G. ; Henri, G. ; Hermann, G. ; Hinton, James Anthony ; Hofmann, W. ; Hoischen, Clemens ; Holch, Tim Lukas ; Holler, M. ; Horns, D. ; Huber, D. ; Iwasaki, H. ; Jacholkowska, A. ; Jamrozy, M. ; Jankowsky, D. ; Jankowsky, F. ; Jouvin, L. ; Jung-Richardt, I ; Kastendieck, M. A. ; Katarzynski, K. ; Katsuragawa, M. ; Katz, U. ; Khangulyan, D. ; Khelifi, B. ; King, J. ; Klepser, S. ; Kluzniak, W. ; Komin, Nu ; Kosack, K. ; Kostunin, D. ; Kraus, M. ; Lamanna, G. ; Lau, J. ; Lemiere, A. ; Lemoine-Goumard, M. ; Lenain, J-P ; Leser, Eva ; Lohse, T. ; Lopez-Coto, R. ; Lypova, I ; Malyshev, D. ; Marandon, V ; Marcowith, Alexandre ; Mariaud, C. ; Marti-Devesa, G. ; Marx, R. ; Maurin, G. ; Maxted, N. ; Meintjes, P. J. ; Mitchell, A. M. W. ; Moderski, R. ; Mohamed, M. ; Mohrmann, L. ; Moore, C. ; Moulin, Emmanuel ; Murach, T. ; Nakashima, S. ; de Naurois, M. ; Ndiyavala, H. ; Niederwanger, F. ; Niemiec, J. ; Oakes, L. ; Odaka, H. ; Ohm, S. ; Wilhelmi, E. de Ona ; Ostrowski, M. ; Oya, I ; Panter, M. ; Parsons, R. D. ; Perennes, C. ; Petrucci, P-O ; Peyaud, B. ; Piel, Q. ; Pita, S. ; Poireau, V ; Noel, A. Priyana ; Prokhorov, D. A. ; Prokoph, H. ; Puehlhofer, G. ; Punch, M. ; Quirrenbach, A. ; Raab, S. ; Rauth, R. ; Reimer, A. ; Reimer, O. ; Renaud, M. ; Rieger, F. ; Rinchiuso, L. ; Romoli, C. ; Rowell, G. ; Rudak, B. ; Ruiz-Velasco, E. ; Sahakian, V ; Saito, S. ; Sanchez, David M. ; Santangelo, Andrea ; Sasaki, M. ; Schlickeiser, R. ; Schussler, F. ; Schulz, A. ; Schutte, H. ; Schwanke, U. ; Schwemmer, S. ; Seglar-Arroyo, M. ; Senniappan, M. ; Seyffert, A. S. ; Shafi, N. ; Shilon, I ; Shiningayamwe, K. ; Simoni, R. ; Sinha, A. ; Sol, H. ; Specovius, A. ; Spir-Jacob, M. ; Stawarz, L. ; Steenkamp, R. ; Stegmann, Christian ; Steppa, Constantin Beverly ; Takahashi, T. ; Tavernet, J-P ; Tavernier, T. ; Taylor, A. M. ; Terrier, R. ; Tibaldo, Luigi ; Tiziani, D. ; Tluczykont, M. ; Trichard, C. ; Tsirou, M. ; Tsuji, N. ; Tuffs, R. ; Uchiyama, Y. ; van der Walt, D. J. ; van Eldik, C. ; van Rensburg, C. ; van Soelen, B. ; Vasileiadis, G. ; Veh, J. ; Venter, C. ; Vincent, P. ; Vink, J. ; Voisin, F. ; Voelk, H. J. ; Vuillaume, T. ; Wadiasingh, Z. ; Wagner, S. J. ; White, R. ; Wierzcholska, A. ; Yang, R. ; Yoneda, H. ; Zaborov, D. ; Zacharias, M. ; Zanin, R. ; Zdziarski, A. A. ; Zech, Alraune ; Ziegler, A. ; Zorn, J. ; Zywucka, N.
Context. Pulsar wind nebulae (PWNe) represent the most prominent population of Galactic very-high-energy gamma-ray sources and are thought to be an efficient source of leptonic cosmic rays. Vela X is a nearby middle-aged PWN, which shows bright X-ray and TeV gamma-ray emission towards an elongated structure called the cocoon. Aims. Since TeV emission is likely inverse-Compton emission of electrons, predominantly from interactions with the cosmic microwave background, while X-ray emission is synchrotron radiation of the same electrons, we aim to derive the properties of the relativistic particles and of magnetic fields with minimal modelling. Methods. We used data from the Suzaku XIS to derive the spectra from three compact regions in Vela X covering distances from 0.3 to 4 pc from the pulsar along the cocoon. We obtained gamma-ray spectra of the same regions from H.E.S.S. observations and fitted a radiative model to the multi-wavelength spectra. Results. The TeV electron spectra and magnetic field strengths are consistent within the uncertainties for the three regions, with energy densities of the order 10(-12) erg cm(-3). The data indicate the presence of a cutoff in the electron spectrum at energies of similar to 100 TeV and a magnetic field strength of similar to 6 mu G. Constraints on the presence of turbulent magnetic fields are weak. Conclusions. The pressure of TeV electrons and magnetic fields in the cocoon is dynamically negligible, requiring the presence of another dominant pressure component to balance the pulsar wind at the termination shock. Sub-TeV electrons cannot completely account for the missing pressure, which may be provided either by relativistic ions or from mixing of the ejecta with the pulsar wind. The electron spectra are consistent with expectations from transport scenarios dominated either by advection via the reverse shock or by diffusion, but for the latter the role of radiative losses near the termination shock needs to be further investigated in the light of the measured cutoff energies. Constraints on turbulent magnetic fields and the shape of the electron cutoff can be improved by spectral measurements in the energy range greater than or similar to 10 keV.
Background There is scant information on the breastmilk vitamin A (BMVA) concentration of lactating women in developing countries, partly due to lack of methods applicable in-field. Objective To assess BMVA concentrations of samples collected from lactating women of children aged 6-23 months, in Mecha district, Ethiopia. Subjects/methods Data on socio-demographic and anthropometric characteristics were collected from randomly selected lactating women (n = 104). Breast milk samples were collected and vitamin A concentrations were analyzed using HPLC and iCheck FLUORO then the two measurements were compared. Results The prevalence of underweight (BMI < 18.5 kg/m(2)) among lactating women was 17%. Seventy six percent of the BMVA values were < 1.05 mu mol/l and 81% were < 8 mu g/g fat. The mean BMVA concentration accounted to 41% of the estimated average value for mothers in developing countries. The BMVA values from HPLC and iCheck were correlated (r = 0.59, p = < 0.001), but it was not strong. Conclusions The result indicates the low vitamin A status of the lactating women and their children. It further indicates that intake assessments should not use average BMVA composition. The possibility of using iCheck for monitoring interventions designed to improve vitamin A status of lactating women with low BMVA requires further investigation.
Abeysekara, A. U. ; Archer, A. ; Benbow, Wystan ; Bird, Ralph ; Brill, A. ; Brose, Robert ; Buchovecky, M. ; Calderon-Madera, D. ; Christiansen, J. L. ; Cui, W. ; Daniel, M. K. ; Falcone, A. ; Feng, Q. ; Fernandez-Alonso, M. ; Finley, J. P. ; Fortson, Lucy ; Furniss, Amy ; Gent, A. ; Giuri, C. ; Gueta, O. ; Hanna, David ; Hassan, T. ; Hervet, Oliver ; Holder, J. ; Hughes, G. ; Humensky, T. B. ; Johnson, Caitlin A. ; Kaaret, P. ; Kertzman, M. ; Kieda, David ; Krause, Maria ; Krennrich, F. ; Kumar, S. ; Lang, M. J. ; Maier, Gernot ; Moriarty, P. ; Mukherjee, Reshmi ; Nievas-Rosillo, M. ; Ong, R. A. ; Pfrang, Konstantin Johannes ; Pohl, Martin ; Prado, R. R. ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Ribeiro, D. ; Richards, G. T. ; Roache, E. ; Rovero, A. C. ; Sadeh, Iftach ; Santander, M. ; Sembroski, G. H. ; Shahinyan, Karlen ; Sushch, Iurii ; Svraka, T. ; Weinstein, A. ; Wells, R. M. ; Wilcox, Patrick ; Wilhelm, Alina ; Williams, David Arnold ; Williamson, T. J. ; Zitzer, B.
The extragalactic background light (EBL), a diffuse photon field in the optical and infrared range, is a record of radiative processes over the universe?s history. Spectral measurements of blazars at very high energies (>100 GeV) enable the reconstruction of the spectral energy distribution (SED) of the EBL, as the blazar spectra are modified by redshift- and energy-dependent interactions of the gamma-ray photons with the EBL. The spectra of 14 VERITAS-detected blazars are included in a new measurement of the EBL SED that is independent of EBL SED models. The resulting SED covers an EBL wavelength range of 0.56?56 ?m, and is in good agreement with lower limits obtained by assuming that the EBL is entirely due to radiation from cataloged galaxies.
Adem, Fozia A. ; Kuete, Victor ; Mbaveng, Armelle T. ; Heydenreich, Matthias ; Koch, Andreas ; Ndakala, Albert ; Irungu, Beatrice ; Yenesew, Abiy ; Efferth, Thomas
A new isoflavone, 4′-prenyloxyvigvexin A (1) and a new pterocarpan, (6aR,11aR)-3,8-dimethoxybitucarpin B (2) were isolated from the leaves of Lonchocarpus bussei and the stem bark of Lonchocarpus eriocalyx, respectively. The extract of L. bussei also gave four known isoflavones, maximaisoflavone H, 7,2′-dimethoxy-3′,4′-methylenedioxyisoflavone, 6,7,3′-trimethoxy-4′,5′-methylenedioxyisoflavone, durmillone; a chalcone, 4-hydroxylonchocarpin; a geranylated phenylpropanol, colenemol; and two known pterocarpans, (6aR,11aR)-maackiain and (6aR,11aR)-edunol. (6aR,11aR)-Edunol was also isolated from the stem bark of L. eriocalyx. The structures of the isolated compounds were elucidated by spectroscopy. The cytotoxicity of the compounds was tested by resazurin assay using drug-sensitive and multidrug-resistant cancer cell lines. Significant antiproliferative effects with IC50 values below 10 μM were observed for the isoflavones 6,7,3′-trimethoxy-4′,5′-methylenedioxyisoflavone and durmillone against leukemia CCRF-CEM cells; for the chalcone, 4-hydroxylonchocarpin and durmillone against its resistant counterpart CEM/ADR5000 cells; as well as for durmillone against the resistant breast adenocarcinoma MDA-MB231/BCRP cells and resistant gliobastoma U87MG.ΔEGFR cells.
Adem, Fozia A. ; Mbaveng, Armelle T. ; Kuete, Victor ; Heydenreich, Matthias ; Ndakala, Albert ; Irungu, Beatrice ; Yenesew, Abiy ; Efferth, Thomas
Background: While incidences of cancer are continuously increasing, drug resistance of malignant cells is observed towards almost all pharmaceuticals. Several isoflavonoids and flavonoids are known for their cytotoxicity towards various cancer cells. Methods: The cytotoxicity of compounds was determined based on the resazurin reduction assay. Caspases activation was evaluated using the caspase-Glo assay. Flow cytometry was used to analyze the cell cycle (propodium iodide (PI) staining), apoptosis (annexin V/PI staining), mitochondrial membrane potential (MMP) (JC-1) and reactive oxygen species (ROS) (H2DCFH-DA). CCRF-CEM leukemia cells were used as model cells for mechanistic studies. Results: Compounds 1, 2 and 4 displayed IC50 values below 20 mu M towards CCRF-CEM and CEM/ADR5000 leukemia cells, and were further tested towards a panel of 7 carcinoma cells. The IC50 values of the compounds against carcinoma cells varied from 16.90 mu M (in resistant U87MG.Delta EGFR glioblastoma cells) to 48.67 mu M (against HepG2 hepatocarcinoma cells) for 1, from 7.85 mu M (in U87MG.Delta EGFR cells) to 14.44 mu M (in resistant MDA-MB231/BCRP breast adenocarcinoma cells) for 2, from 4.96 mu M (towards U87MG.Delta EGFRcells) to 7.76 mu M (against MDA-MB231/BCRP cells) for 4, and from 0.07 mu M (against MDA-MB231 cells) to 2.15 mu M (against HepG2 cells) for doxorubicin. Compounds 2 and 4 induced apoptosis in CCRF-CEM cells mediated by MMP alteration and increased ROS production. Conclusion: The present report indicates that isoflavones and biflavonoids from Ormocarpum kirkii are cytotoxic compounds with the potential of being exploited in cancer chemotherapy. Compounds 2 and 4 deserve further studies to develop new anticancer drugs to fight sensitive and resistant cancer cell lines.
Sea surface temperature (SST) patterns can – as surface climate forcing – affect weather and climate at large distances. One example is El Niño-Southern Oscillation (ENSO) that causes climate anomalies around the globe via teleconnections. Although several studies identified and characterized these teleconnections, our understanding of climate processes remains incomplete, since interactions and feedbacks are typically exhibited at unique or multiple temporal and spatial scales. This study characterizes the interactions between the cells of a global SST data set at different temporal and spatial scales using climate networks. These networks are constructed using wavelet multi-scale correlation that investigate the correlation between the SST time series at a range of scales allowing instantaneously deeper insights into the correlation patterns compared to traditional methods like empirical orthogonal functions or classical correlation analysis. This allows us to identify and visualise regions of – at a certain timescale – similarly evolving SSTs and distinguish them from those with long-range teleconnections to other ocean regions. Our findings re-confirm accepted knowledge about known highly linked SST patterns like ENSO and the Pacific Decadal Oscillation, but also suggest new insights into the characteristics and origins of long-range teleconnections like the connection between ENSO and Indian Ocean Dipole.
Aguado, Felicidad ; Cabalar, Pedro ; Fandiño, Jorge ; Pearce, David ; Perez, Gilberto ; Vidal, Concepcion
In this work we tackle the problem of checking strong equivalence of logic programs that may contain local auxiliary atoms, to be removed from their stable models and to be forbidden in any external context. We call this property projective strong equivalence (PSE). It has been recently proved that not any logic program containing auxiliary atoms can be reformulated, under PSE, as another logic program or formula without them – this is known as strongly persistent forgetting. In this paper, we introduce a conservative extension of Equilibrium Logic and its monotonic basis, the logic of Here-and-There, in which we deal with a new connective ‘|’ we call fork. We provide a semantic characterisation of PSE for forks and use it to show that, in this extension, it is always possible to forget auxiliary atoms under strong persistence. We further define when the obtained fork is representable as a regular formula.
Aguado, Felicidad ; Cabalar, Pedro ; Fandiño, Jorge ; Pearce, David ; Perez, Gilberto ; Vidal-Peracho, Concepcion
Aichner, Bernhard ; Makhmudov, Zafar ; Rajabov, Iljomjon ; Zhang, Qiong ; Pausata, Francesco Salvatore R. ; Werner, Martin ; Heinecke, Liv ; Kuessner, Marie L. ; Feakins, Sarah J. ; Sachse, Dirk ; Mischke, Steffen
The Central Asian Pamir Mountains (Pamirs) are a high-altitude region sensitive to climatic change, with only few paleoclimatic records available. To examine the glacial-interglacial hydrological changes in the region, we analyzed the geochemical parameters of a 31-kyr record from Lake Karakul and performed a set of experiments with climate models to interpret the results. delta D values of terrestrial biomarkers showed insolation-driven trends reflecting major shifts of water vapor sources. For aquatic biomarkers, positive delta D shifts driven by changes in precipitation seasonality were observed at ca. 31-30, 28-26, and 17-14 kyr BP. Multiproxy paleoecological data and modelling results suggest that increased water availability, induced by decreased summer evaporation, triggered higher lake levels during those episodes, possibly synchronous to northern hemispheric rapid climate events. We conclude that seasonal changes in precipitation-evaporation balance significantly influenced the hydrological state of a large waterbody such as Lake Karakul, while annual precipitation amount and inflows remained fairly constant.
Al Nakeeb, Noah ; Kochovski, Zdravko ; Li, Tingting ; Zhang, Youjia ; Lu, Yan ; Schmidt, Bernhard V. K. J.
Self-assembly of block copolymers is a significant area of polymer science. The self-assembly of completely water-soluble block copolymers is of particular interest, albeit a challenging task. In the present work the self-assembly of a linear-brush architecture block copolymer, namely poly(N-vinylpyrrolidone)-b-poly(oligoethylene glycol methacrylate) (PVP-b-POEGMA), in water is studied. Moreover, the assembled structures are crosslinked via alpha-CD host/guest complexation in a supramolecular way. The crosslinking shifts the equilibrium toward aggregate formation without switching off the dynamic equilibrium of double hydrophilic block copolymer (DHBC). As a consequence, the self-assembly efficiency is improved without extinguishing the unique DHBC self-assembly behavior. In addition, decrosslinking could be induced without a change in concentration by adding a competing complexation agent for alpha-CD. The self-assembly behavior was followed by DLS measurement, while the presence of the particles could be observed via cryo-TEM before and after crosslinking.
Al-Halbouni, Djamil ; Holohan, Eoghan P. ; Taheri, Abbas ; Watson, Robert A. ; Polom, Ulrich ; Schoepfer, Martin P. J. ; Emam, Sacha ; Dahm, Torsten
The 2-D distinct element method (DEM) code (PFC2D_V5) is used here to simulate the evolution of subsidence-related karst landforms, such as single and clustered sinkholes, and associated larger-scale depressions. Subsurface material in the DEM model is removed progressively to produce an array of cavities; this simulates a network of subsurface groundwater conduits growing by chemical/mechanical erosion. The growth of the cavity array is coupled mechanically to the gravitationally loaded surroundings, such that cavities can grow also in part by material failure at their margins, which in the limit can produce individual collapse sinkholes. Two end-member growth scenarios of the cavity array and their impact on surface subsidence were examined in the models: (1) cavity growth at the same depth level and growth rate; (2) cavity growth at progressively deepening levels with varying growth rates. These growth scenarios are characterised by differing stress patterns across the cavity array and its overburden, which are in turn an important factor for the formation of sinkholes and uvalalike depressions. For growth scenario (1), a stable compression arch is established around the entire cavity array, hindering sinkhole collapse into individual cavities and favouring block-wise, relatively even subsidence across the whole cavity array. In contrast, for growth scenario (2), the stress system is more heterogeneous, such that local stress concentrations exist around individual cavities, leading to stress interactions and local wall/overburden fractures. Consequently, sinkhole collapses occur in individual cavities, which results in uneven, differential subsidence within a larger-scale depression. Depending on material properties of the cavity-hosting material and the overburden, the larger-scale depression forms either by sinkhole coalescence or by widespread subsidence linked geometrically to the entire cavity array. The results from models with growth scenario (2) are in close agreement with surface morphological and subsurface geophysical observations from an evaporite karst area on the eastern shore of the Dead Sea.
The plasma membrane (PM) is at the interface of plant-pathogen interactions and, thus, many bacterial type-III effector (T3E) proteins target membrane-associated processes to interfere with immunity. The Pseudomonas syringae T3E HopZ1a is a host cell PM-localized effector protein that has several immunity-associated host targets but also activates effector-triggered immunity in resistant backgrounds. Although HopZ1a has been shown to interfere with early defense signaling at the PM, no dedicated PM-associated HopZ1a target protein has been identified until now. Here, we show that HopZ1a interacts with the PM-associated remorin protein NbREM4 from Nicotiana benthamiana in several independent assays. NbREM4 relocalizes to membrane nanodomains after treatment with the bacterial elicitor flg22 and transient overexpression of NbREM4 in N. benthamiana induces the expression of a subset of defense-related genes. We can further show that NbREM4 interacts with the immune-related receptor-like cytoplasmic kinase avrPphB-susceptible 1 (PBS1) and is phosphorylated by PBS1 on several residues in vitro. Thus, we conclude that NbREM4 is associated with early defense signaling at the PM. The possible relevance of the HopZ1a-NbREM4 interaction for HopZ1a virulence and avirulence functions is discussed.
This study is concerned with repair practices that a teacher and students employ to restore intersubjectivity when faced with interactional problems in a Content and Language Integrated Learning (CLIL) classroom. Adopting a conversation analytic (CA) approach, it examines the interactional treatment of students’ verbal and embodied trouble displays in a video-recorded, teacher-fronted geography lesson held in English at a German high school. At the same time, it explores to what extent the repair practices employed are fitted to this specific interactional context. The analysis shows that students’ verbal trouble displays often result in extensive repair sequences, whereas students’ embodied trouble displays are usually met with teacher self-repair in the transition space. In this way, the latter are resolved much earlier and more quickly. The study further reveals practices like reformulation and translation to be especially useful for repairing interactional problems in classrooms in which a foreign language is used as the medium of instruction. The findings may be of interest for prospective as well as practicing teachers in that they provide relevant insights into how interactional trouble can be successfully managed in (CLIL) classroom interaction.
Zinc is an essential trace element, making it crucial to have a reliable biomarker for evaluating an individual’s zinc status. The total serum zinc concentration, which is presently the most commonly used biomarker, is not ideal for this purpose, but a superior alternative is still missing. The free zinc concentration, which describes the fraction of zinc that is only loosely bound and easily exchangeable, has been proposed for this purpose, as it reflects the highly bioavailable part of serum zinc. This report presents a fluorescence-based method for determining the free zinc concentration in human serum samples, using the fluorescent probe Zinpyr-1. The assay has been applied on 154 commercially obtained human serum samples. Measured free zinc concentrations ranged from 0.09 to 0.42 nM with a mean of 0.22 ± 0.05 nM. It did not correlate with age or the total serum concentrations of zinc, manganese, iron or selenium. A negative correlation between the concentration of free zinc and total copper has been seen for sera from females. In addition, the free zinc concentration in sera from females (0.21 ± 0.05 nM) was significantly lower than in males (0.23 ± 0.06 nM). The assay uses a sample volume of less than 10 µL, is rapid and cost-effective and allows us to address questions regarding factors influencing the free serum zinc concentration, its connection with the body’s zinc status, and its suitability as a future biomarker for an individual’s zinc status.
Ground-penetrating radar is widely used to provide highly resolved images of subsurface sedimentary structures, with implications for processes active in the vadose zone. Frequently overlooked among these structures are tunnels excavated by fossorial animals (e.g., moles). We present two repeated ground-penetrating radar surveys performed a year apart in 2016 and 2017. Careful three-dimensional data processing reveals, in each data set, a pattern of elongated structures that are interpreted as a subsurface mole tunnel network. Our data demonstrate the ability of three-dimensional ground-penetrating radar imaging to non-invasively delineate the small animal tunnels (similar to 5 cm diameter) at a higher spatial and geolocation resolution than has previously been achieved. In turn, this makes repeated surveys and, therefore, long-term monitoring possible. Our results offer valuable insight into the understanding of the near-surface and showcase a potential new application for a geophysical method as well as a non-invasive method of ecological surveying.
Aloni, Sapir Shekef ; Perovic, Milena ; Weitman, Michal ; Cohen, Reut ; Oschatz, Martin ; Mastai, Yitzhak
The synthesis of chiral nanoporous carbons based on chiral ionic liquids (CILs) of amino acids as precursors is described. Such unique precursors for the carbonization of CILs yield chiral carbonaceous materials with high surface area (approximate to 620 m(2) g(-1)). The enantioselectivities of the porous carbons are examined by advanced techniques such as selective adsorption of enantiomers using cyclic voltammetry, isothermal titration calorimetry, and mass spectrometry. These techniques demonstrate the chiral nature and high enantioselectivity of the chiral carbon materials. Overall, we believe that the novel approach presented here can contribute significantly to the development of new chiral carbon materials that will find important applications in chiral chemistry, such as in chiral catalysis and separation and in chiral sensors. From a scientific point of view, the approach and results reported here can significantly deepen our understanding of chirality at the nanoscale and of the structure and nature of chiral nonporous materials and surfaces.
Alrefai, Anas ; Mondal, Suvendu Sekhar ; Wruck, Alexander ; Kelling, Alexandra ; Schilde, Uwe ; Brandt, Philipp ; Janiak, Christoph ; Schoenfeld, Sophie ; Weber, Birgit ; Rybakowski, Lawrence ; Herrman, Carmen ; Brennenstuhl, Katlen ; Eidner, Sascha ; Kumke, Michael Uwe ; Behrens, Karsten ; Günter, Christina ; Müller, Holger ; Holdt, Hans-Jürgen
By varying reaction parameters for the syntheses of the hydrogen-bonded metal-imidazolate frameworks (HIF) HIF-1 and HIF-2 (featuring 14 Zn and 14 Co atoms, respectively) to increase their yields and crystallinity, we found that HIF-1 is generated in two different frameworks, named as HIF-1a and HIF-1b. HIF-1b is isostructural to HIF-2. We determined the gas sorption and magnetic properties of HIF-2. In comparison to HIF-1a (Brunauer-Emmett-Teller (BET) surface area of 471m(2) g(-1)), HIF-2 possesses overall very low gas sorption uptake capacities [BET(CO2) surface area=85m(2) g(-1)]. Variable temperature magnetic susceptibility measurement of HIF-2 showed antiferromagnetic exchange interactions between the cobalt(II) high-spin centres at lower temperature. Theoretical analysis by density functional theory confirmed this finding. The UV/Vis-reflection spectra of HIF-1 (mixture of HIF-1a and b), HIF-2 and HIF-3 (with 14 Cd atoms) were measured and showed a characteristic absorption band centered at 340nm, which was indicative for differences in the imidazolate framework.
Paul Frölichs Theorie zur Vergleichbarkeit von Revolutionen-Rekonstruktion eines Modellversuchs
(2019)
Altintas, Zeynep ; Takiden, Aref ; Utesch, Tillmann ; Mroginski, Maria A. ; Schmid, Bianca ; Scheller, Frieder W. ; Süssmuth, Roderich D.
Widely used diagnostic tools make use of antibodies recognizing targeted molecules, but additional techniques are required in order to alleviate the disadvantages of antibodies. Herein, molecular dynamic calculations are performed for the design of high affinity artificial protein binding surfaces for the recognition of neuron specific enolase (NSE), a known cancer biomarker. Computational simulations are employed to identify particularly stabile secondary structure elements. These epitopes are used for the subsequent molecular imprinting, where surface imprinting approach is applied. The molecular imprints generated with the calculated epitopes of greater stability (Cys-Ep1) show better binding properties than those of lower stability (Cys-Ep5). The average binding strength of imprints created with stabile epitopes is found to be around twofold and fourfold higher for the NSE derived peptide and NSE protein, respectively. The recognition of NSE is investigated in a wide concentration range, where high sensitivity (limit of detection (LOD) = 0.5 ng mL(-1)) and affinity (dissociation constant (K-d) = 5.3 x 10(-11)m) are achieved using Cys-Ep1 imprints reflecting the stable structure of the template molecules. This integrated approach employing stability calculations for the identification of stabile epitopes is expected to have a major impact on the future development of high affinity protein capturing binders.
Vagueness
(2019)
Though vague phenomena have been studied extensively for many decades, it is only in recent years that researchers sought the support of quantitative data. This chapter highlights and discusses the insights that experimental methods brought to the study of vagueness. One area focused on are ‘borderline contradictions’, that is, sentences like ‘She is neither tall nor not tall’ that are contradictory when analysed in classical logic, but are actually acceptable as descriptions of borderline cases. The flourishing of theories and experimental studies that borderline contradictions have led to are examined closely. Beyond this illustrative case, an overview of recent studies that concern the classification of types of vagueness, the use of numbers, rounding, number modification, and the general pragmatic status of vagueness is provided.
In this paper we present new data on a subject/non-subject extraction asymmetry in Igbo constituent questions. We provide evidence that the superficially morphological phenomenon reflects a deeper syntactic asymmetry: Unlike wh-non-subjects, wh-subjects cannot undergo local (A) over bar -movement to the left periphery (SpecFoc); rather, they have to stay in their canonical position SpecT. The same constraint also leads to the that-trace effect (absence of the complementizer) in the embedded clause of long subject wh-movement. We argue that what is responsible for the special status of wh-subjects is their high structural position. We provide an optimality-theoretic analysis of the asymmetry that is based on anti-locality: Local subject (A) over bar -movement is excluded because it is too short. Moreover, we address the nature of apparent wh-in-situ in Igbo.
In a previously published article in HIN under the title of “Eduard Dorsch and his unpublished poem on the occasion of Humboldt’s 100th birthday,” I elaborated on Dorsch’s poem that was read in Detroit in front of a German-American audience on Sept. 14, 1869, a day widely celebrated in the US in honor of Humboldt. Although it was not surprising that Dorsch wrote the occasional poem in the first place given his affinities with Humboldt’s world of thought, a discovery of a second occasional poem upon further research in Dorsch’s voluminous papers was indeed unexpected, in this case read on the same date in Monroe, Michigan. Although there are a number of similarities between the Detroit and Monroe versions, there are enough differences that warrant this addendum to my original article.
Andrés-Delgado, Laura ; Ernst, Alexander ; Galardi-Castilla, María ; Bazaga, David ; Peralta, Marina ; Münch, Juliane ; Gonzalez-Rosa, Juan M. ; Marques, Inês ; Tessadori, Federico ; de la Pompa, José Luis ; Vermot, Julien ; Mercader, Nadia
The epicardium, the outer mesothelial layer enclosing the myocardium, plays key roles in heart development and regeneration. During embryogenesis, the epicardium arises from the proepicardium (PE), a cell cluster that appears in the dorsal pericardium (DP) close to the venous pole of the heart. Little is known about how the PE emerges from the pericardial mesothelium. Using a zebrafish model and a combination of genetic tools, pharmacological agents and quantitative in vivo imaging, we reveal that a coordinated collective movement of DP cells drives PE formation. We found that Bmp signaling and the actomyosin cytoskeleton promote constriction of the DP, which enables PE cells to extrude apically. We provide evidence that cell extrusion, which has been described in the elimination of unfit cells from epithelia and the emergence of hematopoietic stem cells, is also a mechanism for PE cells to exit an organized mesothelium and fulfil their developmental fate to form a new tissue layer, the epicardium.
Coherent network partitions
(2019)
Graph clustering is widely applied in the analysis of cellular networks reconstructed from large-scale data or obtained from experimental evidence. Here we introduce a new type of graph clustering based on the concept of coherent partition. A coherent partition of a graph G is a partition of the vertices of G that yields only disconnected subgraphs in the complement of G. The coherence number of G is then the size of the smallest edge cut inducing a coherent partition. A coherent partition of G is optimal if the size of the inducing edge cut is the coherence number of G. Given a graph G, we study coherent partitions and the coherence number in connection to (bi)clique partitions and the (bi)clique cover number. We show that the problem of finding the coherence number is NP-hard, but is of polynomial time complexity for trees. We also discuss the relation between coherent partitions and prominent graph clustering quality measures.
Angelopoulos, Michael ; Westermann, Sebastian ; Overduin, Pier Paul ; Faguet, Alexey ; Olenchenko, Vladimir ; Grosse, Guido ; Grigoriev, Mikhail N.
Thawing of subsea permafrost can impact offshore infrastructure, affect coastal erosion, and release permafrost organic matter. Thawing is usually modeled as the result of heat transfer, although salt diffusion may play an important role in marine settings. To better quantify nearshore subsea permafrost thawing, we applied the CryoGRID2 heat diffusion model and coupled it to a salt diffusion model. We simulated coastline retreat and subsea permafrost evolution as it develops through successive stages of a thawing sequence at the Bykovsky Peninsula, Siberia. Sensitivity analyses for seawater salinity were performed to compare the results for the Bykovsky Peninsula with those of typical Arctic seawater. For the Bykovsky Peninsula, the modeled ice-bearing permafrost table (IBPT) for ice-rich sand and an erosion rate of 0.25m/year was 16.7 m below the seabed 350m offshore. The model outputs were compared to the IBPT depth estimated from coastline retreat and electrical resistivity surveys perpendicular to and crossing the shoreline of the Bykovsky Peninsula. The interpreted geoelectric data suggest that the IBPT dipped to 15-20m below the seabed at 350m offshore. Both results suggest that cold saline water forms beneath grounded ice and floating sea ice in shallow water, causing cryotic benthic temperatures. The freezing point depression produced by salt diffusion can delay or prevent ice formation in the sediment and enhance the IBPT degradation rate. Therefore, salt diffusion may facilitate the release of greenhouse gasses to the atmosphere and considerably affect the design of offshore and coastal infrastructure in subsea permafrost areas.
Das Praxissemester als praxisbezogenes Studienelement zur Förderung von Professions- und Reflexionskompetenzen ist in immer mehr Bundesländern integraler Bestandteil der Lehramtsausbildung. Eine zentrale Herausforderung ist hierbei die gelingende Integration von universitärer Theorie und schulischer Praxis. Das Forschende Lernen kann hierzu einen wichtigen Beitrag leisten, indem Herausforderungen aus der unterrichtlichen Praxis einem forschenden Blick unterzogen und mit wissenschaftlichen Methoden bearbeitet werden. Dies soll nicht zuletzt die Reflexionskompetenz der angehenden Lehrerinnen und Lehrer fördern.
An association between static and dynamic postural control exists in adults with back pain. We aimed to determine whether this association also exists in adolescent athletes with the same condition. In all, 128 athletes with and without back pain performed three measurements of 15s of static (one-legged stance) and dynamic (star excursion balance test) postural control tests. All subjects and amatched subgroup of athletes with and without back pain were analyzed. The smallest center of pressure mediolateral and anterior-posterior displacements (mm) and normalized highest reach distance were the outcome measures. No association was found between variables of the static and dynamic tests for all subjects and the matched group with and without back pain. The control of static and dynamic posture in adolescent athletes with and without back pain might not be related.
Araya Vargas, Jaime Andrés ; Meqbel, Naser M. ; Ritter, Oliver ; Brasse, H. ; Weckmann, Ute ; Yanez, Gonzalo ; Godoy, B.
We present a model of the electrical resistivity structure of the lithosphere in the Central Andes between 20 degrees and 24 degrees S from 3-D inversion of 56 long-period magnetotelluric sites. Our model shows a complex resistivity structure with significant variability parallel and perpendicular to the trench direction. The continental forearc is characterized mainly by high electrical resistivity (>1,000m), suggesting overall low volumes of fluids. However, low resistivity zones (LRZs, <5m) were found in the continental forearc below areas where major trench-parallel faults systems intersect NW-SE transverse faults. Forearc LRZs indicate circulation and accumulation of fluids in highly permeable fault zones. The continental crust along the arc shows three distinctive resistivity domains, which coincide with segmentation in the distribution of volcanoes. The northern domain (20 degrees-20.5 degrees S) is characterized by resistivities >1,000m and the absence of active volcanism, suggesting the presence of a low-permeability block in the continental crust. The central domain (20.5 degrees-23 degrees S) exhibits a number of LRZs at varying depths, indicating different levels of a magmatic plumbing system. The southern domain (23 degrees-24 degrees S) is characterized by resistivities >1,000m, suggesting the absence of large magma reservoirs below the volcanic chain at crustal depths. Magma reservoirs located below the base of the crust or in the backarc may fed active volcanism in the southern domain. In the subcontinental mantle, the model exhibits LRZs in the forearc mantle wedge and above clusters of intermediate-depth seismicity, likely related to fluids produced by serpentinization of the mantle and eclogitization of the slab, respectively.
A Search for Pulsed Very High-energy Gamma-Rays from 13 Young Pulsars in Archival VERITAS Data
(2019)
Archer, A. ; Benbow, Wystan ; Bird, Ralph ; Brose, Robert ; Buchovecky, M. ; Buckley, J. H. ; Chromey, A. J. ; Cui, Wei ; Falcone, A. ; Feng, Qi ; Finley, J. P. ; Fortson, Lucy ; Furniss, Amy ; Gent, A. ; Gueta, O. ; Hanna, David ; Hassan, T. ; Hervet, Olivier ; Holder, J. ; Hughes, G. ; Humensky, T. B. ; Johnson, Caitlin A. ; Kaaret, Philip ; Kar, P. ; Kelley-Hoskins, N. ; Kertzman, M. ; Kieda, David ; Krennrich, F. ; Kumar, S. ; Lang, M. J. ; Lin, T. T. Y. ; McCann, A. ; Moriarty, P. ; Mukherjee, Reshmi ; Ong, R. A. ; Otte, Adam Nepomuk ; Pandel, D. ; Park, N. ; Petrashyk, A. ; Pohl, Martin ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Richards, Gregory T. ; Roache, E. ; Sadeh, I ; Santander, Marcos ; Scott, S. S. ; Sembroski, G. H. ; Shahinyan, Karlen ; Sushch, Iurii ; Tyler, J. ; Wakely, S. P. ; Weinstein, A. ; Wells, R. M. ; Wilcox, P. ; Wilhelm, Alina ; Williams, D. A. ; Williamson, T. J. ; Zitzer, B.
We conduct a search for periodic emission in the very high-energy (VHE) gamma-ray band (E > 100 GeV) from a total of 13 pulsars in an archival VERITAS data set with a total exposure of over 450 hr. The set of pulsars includes many of the brightest young gamma-ray pulsars visible in the Northern Hemisphere. The data analysis resulted in nondetections of pulsed VHE gamma-rays from each pulsar. Upper limits on a potential VHE gamma-ray flux are derived at the 95% confidence level above three energy thresholds using two methods. These are the first such searches for pulsed VHE emission from each of the pulsars, and the obtained limits constrain a possible flux component manifesting at VHEs as is seen for the Crab pulsar.
This paper presents a combination of R packages-user contributed toolkits written in a common core programming language-to facilitate the humanistic investigation of digitised, text-based corpora.Our survey of text analysis packages includes those of our own creation (cleanNLP and fasttextM) as well as packages built by other research groups (stringi, readtext, hyphenatr, quanteda, and hunspell). By operating on generic object types, these packages unite research innovations in corpus linguistics, natural language processing, machine learning, statistics, and digital humanities. We begin by extrapolating on the theoretical benefits of R as an elaborate gluing language for bringing together several areas of expertise and compare it to linguistic concordancers and other tool-based approaches to text analysis in the digital humanities. We then showcase the practical benefits of an ecosystem by illustrating how R packages have been integrated into a digital humanities project. Throughout, the focus is on moving beyond the bag-of-words, lexical frequency model by incorporating linguistically-driven analyses in research.
Models of ring current electron dynamics unavoidably contain uncertainties in boundary conditions, electric and magnetic fields, electron scattering rates, and plasmapause location. Model errors can accumulate with time and result in significant deviations of model predictions from observations. Data assimilation offers useful tools which can combine physics-based models and measurements to improve model predictions. In this study, we systematically analyze performance of the Kalman filter applied to a log-transformed convection model of ring current electrons and Van Allen Probe data. We consider long-term dynamics of mu = 2.3 MeV/G and K = 0.3 G(1/2) R-E electrons from 1 February 2013 to 16 June 2013. By using synthetic data, we show that the Kalman filter is capable of correcting errors in model predictions associated with uncertainties in electron lifetimes, boundary conditions, and convection electric fields. We demonstrate that reanalysis retains features which cannot be fully reproduced by the convection model such as storm-time earthward propagation of the electrons down to 2.5 R-E. The Kalman filter can adjust model predictions to satellite measurements even in regions where data are not available. We show that the Kalman filter can adjust model predictions in accordance with observations for mu = 0.1, 2.3, and 9.9 MeV/G and constant K = 0.3 G(1/2) R-E electrons. The results of this study demonstrate that data assimilation can improve performance of ring current models, better quantify model uncertainties, and help deeper understand the physics of the ring current particles.
Aseev, Nikita ; Shprits, Yuri ; Wang, Dedong ; Wygant, John ; Drozdov, Alexander ; Kellerman, Adam C. ; Reeves, Geoffrey D.
Ring current electrons (1–100 keV) have received significant attention in recent decades, but many questions regarding their major transport and loss mechanisms remain open. In this study, we use the four‐dimensional Versatile Electron Radiation Belt code to model the enhancement of phase space density that occurred during the 17 March 2013 storm. Our model includes global convection, radial diffusion, and scattering into the Earth's atmosphere driven by whistler‐mode hiss and chorus waves. We study the sensitivity of the model to the boundary conditions, global electric field, the electric field associated with subauroral polarization streams, electron loss rates, and radial diffusion coefficients. The results of the code are almost insensitive to the model parameters above 4.5 RERE, which indicates that the general dynamics of the electrons between 4.5 RE and the geostationary orbit can be explained by global convection. We found that the major discrepancies between the model and data can stem from the inaccurate electric field model and uncertainties in lifetimes. We show that additional mechanisms that are responsible for radial transport are required to explain the dynamics of ≥40‐keV electrons, and the inclusion of the radial diffusion rates that are typically assumed in radiation belt studies leads to a better agreement with the data. The overall effect of subauroral polarization streams on the electron phase space density profiles seems to be smaller than the uncertainties in other input parameters. This study is an initial step toward understanding the dynamics of these particles inside the geostationary orbit.
The novel space-borne Global Navigation Satellite System Reflectometry (GNSS-R) technique has recently shown promise in monitoring the ocean state and surface wind speed with high spatial coverage and unprecedented sampling rate. The L-band signals of GNSS are structurally able to provide a higher quality of observations from areas covered by dense clouds and under intense precipitation, compared to those signals at higher frequencies from conventional ocean scatterometers. As a result, studying the inner core of cyclones and improvement of severe weather forecasting and cyclone tracking have turned into the main objectives of GNSS-R satellite missions such as Cyclone Global Navigation Satellite System (CYGNSS). Nevertheless, the rain attenuation impact on GNSS-R wind speed products is not yet well documented. Evaluating the rain attenuation effects on this technique is significant since a small change in the GNSS-R can potentially cause a considerable bias in the resultant wind products at intense wind speeds. Based on both empirical evidence and theory, wind speed is inversely proportional to derived bistatic radar cross section with a natural logarithmic relation, which introduces high condition numbers (similar to ill-posed conditions) at the inversions to high wind speeds. This paper presents an evaluation of the rain signal attenuation impact on the bistatic radar cross section and the derived wind speed. This study is conducted simulating GNSS-R delay-Doppler maps at different rain rates and reflection geometries, considering that an empirical data analysis at extreme wind intensities and rain rates is impossible due to the insufficient number of observations from these severe conditions. Finally, the study demonstrates that at a wind speed of 30 m/s and incidence angle of 30 degrees, rain at rates of 10, 15, and 20 mm/h might cause overestimation as large as approximate to 0.65 m/s (2%), 1.00 m/s (3%), and 1.3 m/s (4%), respectively, which are still smaller than the CYGNSS required uncertainty threshold. The simulations are conducted in a pessimistic condition (severe continuous rainfall below the freezing height and over the entire glistening zone) and the bias is expected to be smaller in size in real environments.
Ashton, Michelle P. ; Eugster, Anne ; Dietz, Sevina ; Loebel, Doreen ; Lindner, Annett ; Kuehn, Denise ; Taranko, Anna E. ; Heschel, Babett ; Gavrisan, Anita ; Ziegler, Anette-Gabriele ; Aringer, Martin ; Bonifacio, Ezio
Awan, Asad Bashir ; Schiebel, Juliane ; Boehm, Alexander ; Nitschke, Joerg ; Sarwar, Yasra ; Schierack, Peter ; Ali, Aamir
Multidrug resistant (MDR) Pseudomonas aeruginosa having strong biofilm potential and virulence factors are a serious threat for hospitalized patients having compromised immunity In this study, 34 P. aeruginosa isolates of human origin (17 MDR and 17 non-MDR clinical isolates) were checked for biofilm formation potential in enriched and minimal media. The biofilms were detected using crystal violet method and a modified software package of the automated VideoScan screening method. Cytotoxic potential of the isolates was also investigated on HepG2, LoVo and T24 cell lines using automated VideoScan technology. Pulse field gel electrophoresis revealed 10 PFGE types in MDR and 8 in non-MDR isolates. Although all isolates showed biofilm formation potential, strong biofilm formation was found more in enriched media than in minimal media. Eight MDR isolates showed strong biofilm potential in both enriched and minimal media by both detection methods. Strong direct correlation between crystal violet and VideoScan methods was observed in identifying strong biofilm forming isolates. High cytotoxic effect was observed by 4 isolates in all cell lines used while 6 other isolates showed high cytotoxic effect on T24 cell line only. Strong association of multidrug resistance was found with biofilm formation as strong biofilms were observed significantly higher in MDR isolates (p-value < 0.05) than non-MDR isolates. No significant association of cytotoxic potential with multidrug resistance or biofilm formation was found (p-value > 0.05). The MDR isolates showing significant cytotoxic effects and strong biofilm formation impose a serious threat for hospitalized patients with weak immune system.
Wealth and income distributions are known to feature country-specific Pareto exponents for their long power-law tails. To propose a rationale for this, we introduce an agent-based dynamic model and use Monte Carlo simulations to unveil the wealth distributions in closed and open economical systems. The standard money-exchange scenario is supplemented with the position-exchange agent dynamics that vitally affects the Pareto law. Specifically, in closed systems with position-exchange dynamics the power law changes to an exponential shape, while for open systems with traps the Pareto law remains valid.
Optical flow models as an open benchmark for radar-based precipitation nowcasting (rainymotion v0.1)
(2019)
Quantitative precipitation nowcasting (QPN) has become an essential technique in various application contexts, such as early warning or urban sewage control. A common heuristic prediction approach is to track the motion of precipitation features from a sequence of weather radar images and then to displace the precipitation field to the imminent future (minutes to hours) based on that motion, assuming that the intensity of the features remains constant (“Lagrangian persistence”). In that context, “optical flow” has become one of the most popular tracking techniques. Yet the present landscape of computational QPN models still struggles with producing open software implementations. Focusing on this gap, we have developed and extensively benchmarked a stack of models based on different optical flow algorithms for the tracking step and a set of parsimonious extrapolation procedures based on image warping and advection. We demonstrate that these models provide skillful predictions comparable with or even superior to state-of-the-art operational software. Our software library (“rainymotion”) for precipitation nowcasting is written in the Python programming language and openly available at GitHub (https://github.com/hydrogo/rainymotion, Ayzel et al., 2019). That way, the library may serve as a tool for providing fast, free, and transparent solutions that could serve as a benchmark for further model development and hypothesis testing – a benchmark that is far more advanced than the conventional benchmark of Eulerian persistence commonly used in QPN verification experiments.
During the last few decades, the rapid separation of the Small Aral Sea from the isolated basin has changed its hydrological and ecological conditions tremendously. In the present study, we developed and validated the hybrid model for the Syr Darya River basin based on a combination of state-of-the-art hydrological and machine learning models. Climate change impact on freshwater inflow into the Small Aral Sea for the projection period 2007-2099 has been quantified based on the developed hybrid model and bias corrected and downscaled meteorological projections simulated by four General Circulation Models (GCM) for each of three Representative Concentration Pathway scenarios (RCP). The developed hybrid model reliably simulates freshwater inflow for the historical period with a Nash-Sutcliffe efficiency of 0.72 and a Kling-Gupta efficiency of 0.77. Results of the climate change impact assessment showed that the freshwater inflow projections produced by different GCMs are misleading by providing contradictory results for the projection period. However, we identified that the relative runoff changes are expected to be more pronounced in the case of more aggressive RCP scenarios. The simulated projections of freshwater inflow provide a basis for further assessment of climate change impacts on hydrological and ecological conditions of the Small Aral Sea in the 21st Century.
OpenForecast
(2019)
Ayzel, Georgy ; Varentsova, Natalia ; Erina, Oxana ; Sokolov, Dmitriy ; Kurochkina, Liubov ; Moreydo, Vsevolod
The development and deployment of new operational runoff forecasting systems are a strong focus of the scientific community due to the crucial importance of reliable and timely runoff predictions for early warnings of floods and flashfloods for local businesses and communities. OpenForecast, the first operational runoff forecasting system in Russia, open for public use, is presented in this study. We developed OpenForecast based only on open-source software and data-GR4J hydrological model, ERA-Interim meteorological reanalysis, and ICON deterministic short-range meteorological forecasts. Daily forecasts were generated for two basins in the European part of Russia. Simulation results showed a limited efficiency in reproducing the spring flood of 2019. Although the simulations managed to capture the timing of flood peaks, they failed in estimating flood volume. However, further implementation of the parsimonious data assimilation technique significantly alleviates simulation errors. The revealed limitations of the proposed operational runoff forecasting system provided a foundation to outline its further development and improvement.
We construct eta- and rho-invariants for Dirac operators, on the universal covering of a closed manifold, that are invariant under the projective action associated to a 2-cocycle of the fundamental group. We prove an Atiyah-Patodi-Singer index theorem in this setting, as well as its higher generalisation. Applications concern the classification of positive scalar curvature metrics on closed spin manifolds. We also investigate the properties of these twisted invariants for the signature operator and the relation to the higher invariants.
We analyse the top tail of the wealth distribution in France, Germany, and Spain using the first and second waves of the Household Finance and Consumption Survey (HFCS). Since top wealth is likely to be under-represented in household surveys, we integrate big fortunes from rich lists, estimate a Pareto distribution, and impute the missing rich. In addition to the Forbes list, we rely on national rich lists since they represent a broader base of the big fortunes in those countries. As a result, the top 1% wealth share increases notably for the three selected countries after imputing the top wealth. We find that national rich lists can improve the estimation of the Pareto coefficient in particular when the list of national USD billionaires is short.
Double Jeopardy
(2019)
The present study investigates whether secondary traumatization (i.e., family history of Holocaust survival and secondary exposure to captivity) is implicated in subjective age. Women exposed to different levels of secondary traumatization (N = 177) were assessed. Analyses of variance (ANOVAs) revealed that a Holocaust background and husband's captivity had a marginally significant positive effect on age appearance. Women with a Holocaust background whose husbands were held captive reported older interest age, indicating double jeopardy for older subjective age when two sources of secondary traumatization are present. A similar trend existed for behavior age. Possible explanations for these complex findings of risk and resilience are discussed.
Baesler, Jessica ; Kopp, Johannes F. ; Pohl, Gabriele ; Aschner, Michael ; Haase, Hajo ; Schwerdtle, Tanja ; Bornhorst, Julia
Baesler, Jessica ; Kopp, Johannes Florian ; Pohl, Gabriele ; Aschner, Michael ; Haase, Hajo ; Schwerdtle, Tanja ; Bornhorst, Julia
While the underlying mechanisms of Parkinson’s disease (PD) are still insufficiently studied, a complex interaction between genetic and environmental factors is emphasized. Nevertheless, the role of the essential trace element zinc (Zn) in this regard remains controversial. In this study we altered Zn balance within PD models of the versatile model organism Caenorhabditis elegans (C. elegans) in order to examine whether a genetic predisposition in selected genes with relevance for PD affects Zn homeostasis. Protein-bound and labile Zn species act in various areas, such as enzymatic catalysis, protein stabilization pathways and cell signaling. Therefore, total Zn and labile Zn were quantitatively determined in living nematodes as individual biomarkers of Zn uptake and bioavailability with inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) or a multi-well method using the fluorescent probe ZinPyr-1. Young and middle-aged deletion mutants of catp-6 and pdr-1, which are orthologues of mammalian ATP13A2 (PARK9) and parkin (PARK2), showed altered Zn homeostasis following Zn exposure compared to wildtype worms. Furthermore, age-specific differences in Zn uptake were observed in wildtype worms for total as well as labile Zn species. These data emphasize the importance of differentiation between Zn species as meaningful biomarkers of Zn uptake as well as the need for further studies investigating the role of dysregulated Zn homeostasis in the etiology of PD.
Bald, Ilko ; Schürmann, Robin Mathis ; Ebel, Kenny ; Nicolas, Christophe ; Milosavljevic, Aleksandar R.
Hot-electron-induced reactions are more and more recognized as a critical and ubiquitous reaction in heterogeneous catalysis. However, the kinetics of these reactions is still poorly understood, which is also due to the complexity of plasmonic nanostructures. We determined the reaction rates of the hot-electron-mediated reaction of 4-nitrothiophenol (NTP) on gold nanoparticles (AuNPs) using fractal kinetics as a function of the laser wavelength and compared them with the plasmonic enhancement of the system. The reaction rates can be only partially explained by the plasmonic response of the NPs. Hence, synchrotron X-ray photoelectron spectroscopy (XPS) measurements of isolated NTP-capped AuNP clusters have been performed for the first time. In this way, it was possible to determine the work function and the accessible valence band states of the NP systems. The results show that besides the plasmonic enhancement, the reaction rates are strongly influenced by the local density of the available electronic states of the system.
Sensors composed of a porous silicon monolayer covered with a film of nanostructured gold layer, which provide two optical signal transduction methods, are fabricated and thoroughly characterized concerning their sensing performance. For this purpose, silicon substrates were electrochemically etched in order to obtain porous silicon monolayers, which were subsequently immersed in gold salt solution facilitating the formation of a porous gold nanoparticle layer on top of the porous silicon. The deposition process was monitored by reflectance spectroscopy, and the appearance of a dip in the interference pattern of the porous silicon layer was observed. This dip can be assigned to the absorption of light by the deposited gold nanostructures leading to localized surface plasmon resonance. The bulk sensitivity of these sensors was determined by recording reflectance spectra in media having different refractive indices and compared to sensors exclusively based on porous silicon or gold nanostructures. A thorough analysis of resulting shifts of the different optical signals in the reflectance spectra on the wavelength scale indicated that the optical response of the porous silicon sensor is not influenced by the presence of a gold nanostructure on top. Moreover, the adsorption of thiol-terminated polystyrene to the sensor surface was solely detected by changes in the position of the dip in the reflectance spectrum, which is assigned to localized surface plasmon resonance in the gold nanostructures. The interference pattern resulting from the porous silicon layer is not shifted to longer wavelengths by the adsorption indicating the independence of the optical response of the two nanostructures, namely porous silicon and nanostructured gold layer, to refractive index changes and pointing to the successful realization of two sensors in one spot.
This study investigates the effect of different anticonsumption constructs on consumer wellbeing. The study assumes that people will only lower their level of consumption if doing so does not also lower personal wellbeing. More precisely, this research investigates how specific subtypes of sustainable anticonsumption (e.g., voluntary simplicity, collaborative consumption, and debt-free living) relate to different states of consumer's wellbeing (e.g., financial, psychosocial, and subjective wellbeing). This work also examines whether consumer empowerment can improve personal wellbeing and strengthen the anticonsumption wellbeing relationship. The results show that voluntarily foregoing consumption does not reduce wellbeing and consumer empowerment plays a significant role in supporting sustainable pathways to consumer wellbeing. This study reasons that empowerment improves consumer sovereignty, but may be detrimental for consumers heavily concerned about debt-free living. The present investigation concludes by proposing implications for public and consumer policymakers wishing to promote appropriate sustainable (anticonsumption) pathways to consumer wellbeing.
Quadruple-shape hydrogels
(2019)
The capability of directed movements by two subsequent shape changes could be implemented in shape-memory hydrogels by incorporation of two types of crystallizable side chains While in non-swollen polymer networks even more directed movements could be realized, the creation of multi-shape hydrogels is still a challenge. We hypothesize that a quadruple-shape effect in hydrogels can be realized, when a swelling capacity almost independent of temperature is generated, whereby directed movements could be enabled, which are not related to swelling. In this case, entropy elastic recovery could be realized by hydrophilic segments and the fixation of different macroscopic shapes by means of three semi-crystalline side chains generating temporary crosslinks. Monomethacrylated semi-crystalline oligomers were connected as side chains in a hydrophilic polymer network via radical copolymerization. Computer assisted modelling was utilized to design a demonstrator capable of complex shape shifts by creating a casting mold via 3D printing from polyvinyl alcohol. The demonstrator was obtained after copolymerization of polymer network forming components within the mold, which was subsequently dissolved in water. A thermally-induced quadruple-shape effect was realized after equilibrium swelling of the polymer network in water. Three directed movements were successfully obtained when the temperature was continuously increased from 5 degrees C to 90 degrees C with a recovery ratio of the original shape above 90%. Hence, a thermally-induced quadruple-shape effect as new record for hydrogels was realized. Here, the temperature range for the multi-shape effect was limited by water as swelling media (0 degrees C-100 degrees C), simultaneously distinctly separated thermal transitions were required, and the overall elasticity indispensable for successive deformations was reduced as result of partially chain segment orientation induced by swelling in water. Conclusively the challenges for penta- or hexa-shape gels are the design of systems enabling higher elastic deformability and covering a larger temperature range by switching to a different solvent.
Shape-memory polymer actuators often contain crystallizable polyester segments. Here, the influence of accelerated hydrolytic degradation on the actuation performance in copolymer networks based on oligo(epsilon-caprolactone) dimethacrylate (OCL) and n-butyl acrylate is studied The semi-crystalline OCL was utilized as crosslinker with molecular weights of 2.3 and 15.2 kg.mol(-1) (ratio: 1:1 wt%) and n-butyl acrylate (25 wt% relative to OCL content) acted as softening agent creating the polymer main chain segments within the network architecture. The copolymer networks were programmed by 50% elongation and were degraded by means of alkaline hydrolysis utilizing sodium hydroxide solution (pH = 13). Experiments were performed in the range of the broad melting range of the actuators at 40 degrees C. The degradation of test specimen was monitored by the sample mass, which was reduced by 25 wt% within 105 d .45 degradation products, fragments of OCL with molecular masses ranging from 400 to 50.000 g.mol(-1) could be detected by NMR spectroscopy and GPC measurements. The cleavage of ester groups included in OCL segments resulted in a decrease of the melting temperature (T-m) related to the actuator domains (amorphous at the temperature of degradation) and simultaneously, the T-m associated to the skeleton domain was increased (semi-crystalline at the temperature of degradation). The alkaline hydrolysis decreased the polymer chain orientation of OCL domains until a random alignment of crystalline domains was obtained. This result was confirmed by cyclic thermomechanical actuation tests. The performance of directed movements decreased almost linearly as function of degradation time resulting in the loss of functionality when the orientation of polymer chains disappeared. Here, actuators were able to provide reversible movements until 91 d when the accelerated bulk degradation procedure using alkaline hydrolysis (pH = 13) was applied. Accordingly, a lifetime of more than one year can be guaranteed under physiological conditions (pH = 7.4) when, e.g., artificial muscles for biomimetic robots as potential application for these kind of shape-memory polymer actuators will be addressed.
The removal, redistribution, and transient storage of sediments in tectonically active mountain belts is thought to exert a first-order control on shallow crustal stresses, fault activity, and hence on the spatiotemporal pattern of regional deformation processes. Accordingly, sediment loading and unloading cycles in intermontane sedimentary basins may inhibit or promote intrabasinal faulting, respectively, but unambiguous evidence for this potential link has been elusive so far. Here we combine 2D numerical experiments that simulate contractional deformation in a broken-foreland setting (i.e., a foreland where shortening is diachronously absorbed by spatially disparate, reverse faults uplifting basement blocks) with field data from intermontane basins in the NW Argentine Andes. Our modeling results suggest that thicker sedimentary fills (>0.7-1.0 km) may suppress basinal faulting processes, while thinner fills (<0.7 km) tend to delay faulting. Conversely, the removal of sedimentary loads via fluvial incision and basin excavation promotes renewed intrabasinal faulting. These results help to better understand the tectono-sedimentary history of intermontane basins that straddle the eastern border of the Andean Plateau in northwestern Argentina. For example, the Santa Maria and the Humahuaca basins record intrabasinal deformation during or after sediment unloading, while the Quebrada del Toro Basin reflects the suppression of intrabasinal faulting due to loading by coarse conglomerates. We conclude that sedimentary loading and unloading cycles may exert a fundamental control on spatiotemporal deformation patterns in intermontane basins of tectonically active broken forelands. (C) 2018 Elsevier B.V. All rights reserved.
On a smooth complete Riemannian spin manifold with smooth compact boundary, we demonstrate that Atiyah-Singer Dirac operator in depends Riesz continuously on perturbations of local boundary conditions The Lipschitz bound for the map depends on Lipschitz smoothness and ellipticity of and bounds on Ricci curvature and its first derivatives as well as a lower bound on injectivity radius away from a compact neighbourhood of the boundary. More generally, we prove perturbation estimates for functional calculi of elliptic operators on manifolds with local boundary conditions.
Recent years have seen a considerable broadening of the ambitions in urban sustainability policy-making. With its Sustainable Development Goal (SDG) 11 Making cities and human settlements inclusive, safe, resilient and sustainable, the 2030 Agenda stresses the critical role of cities in achieving sustainable development. In the context of SDG17 on partnerships, emphasis is also placed on the role of researchers and other scientific actors as change agents in the sustainability transformation. Against this backdrop, this article sheds light on different pathways through which science can contribute to urban sustainability. In particular, we discern four forms of science-policy-society interactions as key vectors: 1. sharing knowledge and providing scientific input to urban sustainability policy-making; 2. implementing transformative research projects; 3. contributing to local capacity building; and 4. self-governing towards sustainability. The pathways of influence are illustrated with empirical examples, and their interlinkages and limitations are discussed. We contend that there are numerous opportunities for actors from the field of sustainability science to engage with political and societal actors to enhance sustainable development at the local level.
Baran, Andrzej S. ; Telting, J. H. ; Jeffery, C. Simon ; Ostensen, R. H. ; Vos, Joris ; Reed, M. D. ; Vŭcković, Maja
We present an analysis of two pulsating subdwarf B stars PHL 457 and EQ Psc observed during the K2 mission. The K2 light curves of both stars show variation consistent with irradiation of a cooler companion by the hot subdwarf. They also show higher frequency oscillations consistent with pulsation. Using new spectroscopic data, we measured the radial velocity, effective temperature, surface gravity, and helium abundance of both hot subdwarfs as a function of orbital phase. We confirm the previously published spectroscopic orbit of PHL 457, and present the first spectroscopic orbit of EQ Psc. The orbital periods are 0.313 and 0.801 d, respectively. For EQPsc, we find a strong correlation between T-eff and orbital phase, due to contribution of light from the irradiated companion. We calculated amplitude spectra, identified significant pulsation frequencies, and searched for multiplets and asymptotic period spacings. By means of multiplets and period spacing, we identified the degrees of several pulsation modes in each star. The g-mode multiplets indicate subsynchronous core rotation with periods of 4.6 d (PHL 457) and 9.4 d (EQ Psc). We made spectral energy disctribution (SED) fits of PHL 457 and EQ Psc using available broad-band photometry and Gaia data. While the SED of PHL 457 shows no evidence of a cool companion, the SED for EQPsc clearly shows an infrared (IR) access consistent with a secondary with a temperature of about 6800K and a radius of 0.23 R-circle dot. This is the first detection of an IR access in any sdB + dM binary.
Barbosa, Luis Romero ; de Lira, Nicholas Borges ; Rabelo Coelho, Victor Hugo ; Bernard Passerat de Silans, Alain Marie ; Gadelha, Andre Nobrega ; Almeida, Cristiano das Neves
Above and underground hydrological processes depend on soil moisture (SM) variability, driven by different environmental factors that seldom are well-monitored, leading to a misunderstanding of soil water temporal patterns. This study investigated the stability of the SM temporal dynamics to different monitoring temporal resolutions around the border between two soil types in a tropical watershed. Four locations were instrumented in a small-scale watershed (5.84 km(2)) within the tropical coast of Northeast Brazil, encompassing different soil types (Espodossolo Humiluvico or Carbic Podzol, and Argissolo Vermelho-Amarelo or Haplic Acrisol), land covers (Atlantic Forest, bush vegetation, and grassland) and topographies (flat and moderate slope). The SM was monitored at a temporal resolution of one hour along the 2013-2014 hydrological year and then resampled a resolutions of 6 h, 12 h, 1 day, 2 days, 4 days, 7 days, and 15 days. Descriptive statistics, temporal variability, time-stability ranking, and hierarchical clustering revealed uneven associations among SM time components. The results show that the time-invariant component ruled SM temporal variability over the time-varying parcel, either at high or low temporal resolutions. Time-steps longer than 2 days affected the mean statistical metrics of the SM time-variant parcel. Additionally, SM at downstream and upstream sites behaved differently, suggesting that the temporal mean was regulated by steady soil properties (slope, restrictive layer, and soil texture), whereas their temporal anomalies were driven by climate (rainfall) and hydrogeological (groundwater level) factors. Therefore, it is concluded that around the border between tropical soil types, the distinct behaviour of time-variant and time-invariant components of SM time series reflects different combinations of their soil properties.
Barchewitz, Tino ; Guljamow, Arthur ; Meißner, Sven ; Timm, Stefan ; Henneberg, Manja ; Baumann, Otto ; Hagemann, Martin ; Dittmann, Elke
The frequent production of the hepatotoxin microcystin (MC) and its impact on the lifestyle of bloom-forming cyanobacteria are poorly understood. Here, we report that MC interferes with the assembly and the subcellular localization of RubisCO, in Microcystis aeruginosa PCC7806. Immunofluorescence, electron microscopic and cellular fractionation studies revealed a pronounced heterogeneity in the subcellular localization of RubisCO. At high cell density, RubisCO particles are largely separate from carboxysomes in M. aeruginosa and relocate to the cytoplasmic membrane under high-light conditions. We hypothesize that the binding of MC to RubisCO promotes its membrane association and enables an extreme versatility of the enzyme. Steady-state levels of the RubisCO CO2 fixation product 3-phosphoglycerate are significantly higher in the MC-producing wild type. We also detected noticeable amounts of the RubisCO oxygenase reaction product secreted into the medium that may support the mutual interaction of M. aeruginosa with its heterotrophic microbial community.
The Value of Empirical Data for Estimating the Parameters of a Sociohydrological Flood Risk Model
(2019)
Barendrecht, Marlies H. ; Viglione, Alberto ; Kreibich, Heidi ; Merz, Bruno ; Vorogushyn, Sergiy ; Blöschl, G.
In this paper, empirical data are used to estimate the parameters of a sociohydrological flood risk model. The proposed model, which describes the interactions between floods, settlement density, awareness, preparedness, and flood loss, is based on the literature. Data for the case study of Dresden, Germany, over a period of 200years, are used to estimate the model parameters through Bayesian inference. The credibility bounds of their estimates are small, even though the data are rather uncertain. A sensitivity analysis is performed to examine the value of the different data sources in estimating the model parameters. In general, the estimated parameters are less biased when using data at the end of the modeled period. Data about flood awareness are the most important to correctly estimate the parameters of this model and to correctly model the system dynamics. Using more data for other variables cannot compensate for the absence of awareness data. More generally, the absence of data mostly affects the estimation of the parameters that are directly related to the variable for which data are missing. This paper demonstrates that combining sociohydrological modeling and empirical data gives additional insights into the sociohydrological system, such as quantifying the forgetfulness of the society, which would otherwise not be easily achieved by sociohydrological models without data or by standard statistical analysis of empirical data.
In Germany, the irrigation sector accounts for only 1% of water use. In recent years, however, this sector has attracted more attention due to the occurrence of severe drought periods. Irrigation scheduling systems could support adaptation strategies but little is known about current providers, performance and users. In this study we aimed to depict the current situation of the existence and functioning of irrigation scheduling systems available in Germany. Six methods were identified and assessed based on direct interviews with end-users and a comparative analysis. The results showed a positive feedback from the users. However, the recommendations were rarely implemented, while only the seasonal irrigation requirement was considered to support actual water abstraction. These results were corroborated by the comparative analysis. Five of the six irrigation scheduling systems estimated the seasonal irrigation amount consistently, while wider differences were found by looking at the irrigation season and at the number of irrigations. Overall, it is found that irrigation support systems are valuable tools for supporting adaptation strategies to fast changes in agro-environmental conditions. However, specific assessments based on real measurements should be considered in order to improve the performance of the systems and provide more consistent support to end-users. (c) 2019 John Wiley & Sons, Ltd.
Baroni, Gabriele ; Schalge, Bernd ; Rakovec, Oldrich ; Kumar, Rohini ; Schüler, Lennart ; Samaniego, Luis ; Simmer, Clemens ; Attinger, Sabine
The improvement of process representations in hydrological models is often only driven by the modelers' knowledge and data availability. We present a comprehensive comparison between two hydrological models of different complexity that is developed to support (1) the understanding of the differences between model structures and (2) the identification of the observations needed for model assessment and improvement. The comparison is conducted on both space and time and by aggregating the outputs at different spatiotemporal scales. In the present study, mHM, a process‐based hydrological model, and ParFlow‐CLM, an integrated subsurface‐surface hydrological model, are used. The models are applied in a mesoscale catchment in Germany. Both models agree in the simulated river discharge at the outlet and the surface soil moisture dynamics, lending their supports for some model applications (drought monitoring). Different model sensitivities are, however, found when comparing evapotranspiration and soil moisture at different soil depths. The analysis supports the need of observations within the catchment for model assessment, but it indicates that different strategies should be considered for the different variables. Evapotranspiration measurements are needed at daily resolution across several locations, while highly resolved spatially distributed observations with lower temporal frequency are required for soil moisture. Finally, the results show the impact of the shallow groundwater system simulated by ParFlow‐CLM and the need to account for the related soil moisture redistribution. Our comparison strategy can be applied to other models types and environmental conditions to strengthen the dialog between modelers and experimentalists for improving process representations in Earth system models.
Barth, Sophia ; Geertsema, Marten ; Bevington, Alexandre R. ; Bird, Alison L. ; Clague, John J. ; Millard, Tom ; Bobrowsky, Peter T. ; Hasler, Andreas ; Liu, Hongjiang
In this paper, we examine the influence of the 27 October 2012, M-w 7.8 earthquake on landslide occurrence in the southern half of Haida Gwaii (formerly Queen Charlotte Islands), British Columbia, Canada. Our 1350 km(2) study area is undisturbed, primarily forested terrain that has not experienced road building or timber harvesting. Our inventory of landslide polygons is based on optical airborne and spaceborne images acquired between 2007 and 2018, from which we extracted and mapped 446 individual landslides (an average of 33 landslides per 100 km(2)). The landslide rate in years without major earthquakes averages 19.4 per year, or 1.4/100 km(2)/year, and the annual average area covered by non-seismically triggered landslides is 35 ha/year. The number of landslides identified in imagery closely following the 2012 earthquake, and probably triggered by it, is 244 or an average of about 18 landslides per 100 km(2). These landslides cover a total area of 461 ha. In the following years-2013-2016 and 2016-2018-the number of landslides fell, respectively, to 26 and 13.5 landslides per year. In non-earthquake years, most landslides happen on south-facing slopes, facing the prevailing winds. In contrast, during or immediately after the earthquake, up to 32% of the landslides occurred on north and northwest-facing slopes. Although we could not find imagery from the day after the earthquake, overview reconnaissance flights 10 and 16 days later showed that most of the landslides were recent, suggesting they were co-seismic.
Bartha-Doering, Lisa ; Alexopoulos, Johanna ; Giordano, Vito ; Stelzer, Lisa ; Kainz, Theresa ; Benavides-Varela, Silvia ; Wartenburger, Isabell ; Klebermass-Schrehof, Katrin ; Olischar, Monika ; Seidl, Rainer Otis ; Berger, Angelika
Children born preterm are at higher risk to develop language deficits. Auditory speech discrimination deficits may be early signs for language developmental problems. The present study used functional near-infrared spectroscopy to investigate neural speech discrimination in 15 preterm infants at term-equivalent age compared to 15 full term neonates. The full term group revealed a significantly greater hemodynamic response to forward compared to backward speech within the left hemisphere extending from superior temporal to inferior parietal and middle and inferior frontal areas. In contrast, the preterm group did not show differences in their hemodynamic responses during forward versus backward speech, thus, they did not discriminate speech from nonspeech. Groups differed significantly in their responses to forward speech, whereas they did not differ in their responses to backward speech. The significant differences between groups point to an altered development of the functional network underlying language acquisition in preterm infants as early as in term-equivalent age.
Verbraucherbildung ist bundesweit vielfältig in curricularen Vorgaben verankert. Fachfremde Lehrpersonen benötigen Professionalisierungsangebote, um die Verbraucherbildung
als Querschnittsaufgabe in ihren Fächern implementieren zu können. Erkenntnisse aus der Professionalisierungsforschung werden daher im Beitrag in Bezug auf das cLEVER-Projekt
zusammengetragen, um sie für Fortbildungsangebote nutzbar zu machen.
Basaran, Nursen ; Duydu, Yalcin ; Ustundag, Aylin ; Taner, Gokce ; Aydin, Sevtap ; Anlar, Hatice Gul ; Yalcin, Can Özgür ; Bacanli, Merve ; Aydos, Kaan ; Atabekoglu, Cem Somer ; Golka, Klaus ; Ickstadt, Katja ; Schwerdtle, Tanja ; Werner, Matthias ; Meyer, Sören ; Bolt, Hermann M.
Industrial production and use of boron compounds have increased during the last decades, especially for the manufacture of borosilicate glass, fiberglass, metal alloys and flame retardants. This study was conducted in two districts of Balikesir; Bandirma and Bigadic, which geographically belong to the Marmara Region of Turkey. Bandirma is the production and exportation zone for the produced boric acid and some borates and Bigadic has the largest B deposits in Turkey. 102 male workers who were occupationally exposed to boron from Bandirma and 110 workers who were occupationally and environmentally exposed to boron from Bigadic participated to our study. In this study the DNA damage in the sperm, blood and buccal cells of 212 males was evaluated by comet and micronucleus assays. No significant increase in the DNA damage in blood, sperm and buccal cells was observed in the residents exposed to boron both occupationally and environmentally (p = 0.861) for Comet test in the sperm samples, p = 0.116 for Comet test in the lymphocyte samples, p = 0.042 for micronucleus (MN) test, p = 0.955 for binucleated cells (BN), p = 1.486 for condensed chromatin (CC), p = 0.455 for karyorrhectic cells (KHC), p = 0.541 for karyolitic cells (KLY), p = 1.057 for pyknotic cells (PHC), p = 0.331 for nuclear bud (NBUD)). No correlations were seen between blood boron levels and tail intensity values of the sperm samples, lymphocyte samples, frequencies of MN, BN, KHC, KYL, PHC and NBUD. The results of this study came to the same conclusions of the previous studies that boron does not induce DNA damage even under extreme exposure conditions.
The endosperm is an ephemeral tissue that nourishes the developing embryo, similar to the placenta in mammals. In most angiosperms, endosperm development starts as a syncytium, in which nuclear divisions are not followed by cytokinesis. The timing of endosperm cellularization largely varies between species, and the event triggering this transition remains unknown. Here we show that increased auxin biosynthesis in the endosperm prevents its cellularization, leading to seed arrest. Auxin-overproducing seeds phenocopy paternal-excess triploid seeds derived from hybridizations of diploid maternal plants with tetraploid fathers. Concurrently, auxin-related genes are strongly overexpressed in triploid seeds, correlating with increased auxin activity. Reducing auxin biosynthesis and signaling reestablishes endosperm cellularization in triploid seeds and restores their viability, highlighting a causal role of increased auxin in preventing endosperm cellularization. We propose that auxin determines the time of endosperm cellularization, and thereby uncovered a central role of auxin in establishing hybridization barriers in plants.
Batista, Rita A. ; Moreno-Romero, Jordi ; Qiu, Yichun ; van Boven, Joram ; Santos-Gonzalez, Juan ; Figueiredo, Duarte Dionisio ; Köhler, Claudia
MADS-box transcription factors (TFs) are ubiquitous in eukaryotic organisms and play major roles during plant development. Nevertheless, their function in seed development remains largely unknown. Here, we show that the imprinted Arabidopsis thaliana MADS-box TF PHERES1 (PHE1) is a master regulator of paternally expressed imprinted genes, as well as of non-imprinted key regulators of endosperm development. PHE1 binding sites show distinct epigenetic modifications on maternal and paternal alleles, correlating with parental-specific transcriptional activity. Importantly, we show that the CArG-box-like DNA-binding motifs that are bound by PHE1 have been distributed by RC/Helitron transposable elements. Our data provide an example of the molecular domestication of these elements which, by distributing PHE1 binding sites throughout the genome, have facilitated the recruitment of crucial endosperm regulators into a single transcriptional network.
The nuclear envelope consists of the outer and the inner nuclear membrane, the nuclear lamina and the nuclear pore complexes, which regulate nuclear import and export.The major constituent of the nuclear lamina of Dictyostelium is the lamin NE81. It can form filaments like B-type lamins and it interacts with Sun 1, as well as with the LEM/HeH-family protein Src1. Sun 1 and Src1 are nuclear envelope transmembrane proteins involved in the centrosome-nucleus connection and nuclear envelope stability at the nucleolar regions, respectively. In conjunction with a KASH-domain protein, Sun 1 usually forms a so-called LINC complex.Two proteins with functions reminiscent of KASH-domain proteins at the outer nuclear membrane of Dictyostelium are known; interaptin which serves as an actin connector and the kinesin Kif9 which plays a role in the microtubule-centrosome connector. However, both of these lack the conserved KASH-domain. The link of the centrosome to the nuclear envelope is essential for the insertion of the centrosome into the nuclear envelope and the appropriate spindle formation. Moreover, centrosome insertion is involved in perm eabilization of the mitotic nucleus, which ensures access of tubulin dimers and spindle assembly factors. Our recent progress in identifying key molecular players at the nuclear envelope of Dictyostelium promises further insights into the mechanisms of nuclear envelope dynamics.
Batsios, Petros ; Ishikawa-Ankerhold, Hellen Christina ; Roth, Heike ; Schleicher, Michael ; Wong, Catherine C. L. ; Müller-Taubenberger, Annette
The highly conserved enzyme arginyl-tRNA-protein transferase (Ate1) mediates arginylation, a posttranslational modification that is only incompletely understood at its molecular level. To investigate whether arginylation affects actin-dependent processes in a simple model organism, Dictyostelium discoideum, we knocked out the gene encoding Ate1 and characterized the phenotype of ate1-null cells. Visualization of actin cytoskeleton dynamics by live-cell microscopy indicated significant changes in comparison to wild-type cells. Ate1-null cells were almost completely lacking focal actin adhesion sites at the substrate-attached surface and were only weakly adhesive. In two-dimensional chemotaxis assays toward folate or cAMP, the motility of ate1-null cells was increased. However, in three-dimensional chemotaxis involving more confined conditions, the motility of ate1-null cells was significantly reduced. Live-cell imaging showed that GFP-tagged Ate1 rapidly relocates to sites of newly formed actin-rich protrusions. By mass spectrometric analysis, we identified four arginylation sites in the most abundant actin isoform of Dictyostelium, in addition to arginylation sites in other actin isoforms and several actin-binding proteins. In vitro polymerization assays with actin purified from ate1-null cells revealed a diminished polymerization capacity in comparison to wild-type actin. Our data indicate that arginylation plays a crucial role in the regulation of cytoskeletal activities.
Kyub
(2019)
Baudisch, Patrick Markus ; Silber, Arthur ; Kommana, Yannis ; Gruner, Milan ; Wall, Ludwig ; Reuss, Kevin ; Heilman, Lukas ; Kovacs, Robert ; Rechlitz, Daniel ; Roumen, Thijs
We present an interactive editing system for laser cutting called kyub. Kyub allows users to create models efficiently in 3D, which it then unfolds into the 2D plates laser cutters expect. Unlike earlier systems, such as FlatFitFab, kyub affords construction based on closed box structures, which allows users to turn very thin material, such as 4mm plywood, into objects capable of withstanding large forces, such as chairs users can actually sit on. To afford such sturdy construction, every kyub project begins with a simple finger-joint "boxel"-a structure we found to be capable of withstanding over 500kg of load. Users then extend their model by attaching additional boxels. Boxels merge automatically, resulting in larger, yet equally strong structures. While the concept of stacking boxels allows kyub to offer the strong affordance and ease of use of a voxel-based editor, boxels are not confined to a grid and readily combine with kuyb's various geometry deformation tools. In our technical evaluation, objects built with kyub withstood hundreds of kilograms of loads. In our user study, non-engineers rated the learnability of kyub 6.1/7.
While public–private partnerships (PPPs) have surged worldwide since the 1990s, they have been met with growing skepticism during the last years. A recent revision of Germany’s constitutional rules on motorway construction and observations on the use of PPPs published by both the German and the European Courts of Auditors illustrate this new caution. These two examples fit into a general trend towards a revival of the public sector, which can be summarized under the cross-level umbrella term “publicization.” It would, however, be remiss to replace the uncritical euphoria that once surrounded privatization with a similarly undifferentiated euphoria regarding publicization. Rather, it is crucial to identify the most appropriate solution for the fulfilment of each public task from the “toolbox” of publicization on the one hand and privatization on the other hand in order to ensure the most effective completion of public functions.
Bayona Viveros, Jose Antonio ; von Specht, Sebastian ; Strader, Anne ; Hainzl, Sebastian ; Cotton, Fabrice ; Schorlemmer, Danijel
The Seismic Hazard Inferred from Tectonics based on the Global Strain Rate Map (SHIFT_GSRM) earthquake forecast was designed to provide high-resolution estimates of global shallow seismicity to be used in seismic hazard assessment. This model combines geodetic strain rates with global earthquake parameters to characterize long-term rates of seismic moment and earthquake activity. Although SHIFT_GSRM properly computes seismicity rates in seismically active continental regions, it underestimates earthquake rates in subduction zones by an average factor of approximately 3. We present a complementary method to SHIFT_GSRM to more accurately forecast earthquake rates in 37 subduction segments, based on the conservation of moment principle and the use of regional interface seismicity parameters, such as subduction dip angles, corner magnitudes, and coupled seismogenic thicknesses. In seven progressive steps, we find that SHIFT_GSRM earthquake-rate underpredictions are mainly due to the utilization of a global probability function of seismic moment release that poorly captures the great variability among subduction megathrust interfaces. Retrospective test results show that the forecast is consistent with the observations during the 1 January 1977 to 31 December 2014 period. Moreover, successful pseudoprospective evaluations for the 1 January 2015 to 31 December 2018 period demonstrate the power of the regionalized earthquake model to properly estimate subduction-zone seismicity.
The interplay between process and decision models plays a crucial role in business process management, as decisions may be based on running processes and affect process outcomes. Often process models include decisions that are encoded through process control flow structures and data flow elements, thus reducing process model maintainability. The Decision Model and Notation (DMN) was proposed to achieve separation of concerns and to possibly complement the Business Process Model and Notation (BPMN) for designing decisions related to process models. Nevertheless, deriving decision models from process models remains challenging, especially when the same data underlie both process and decision models. In this paper, we explore how and to which extent the data modeled in BPMN processes and used for decision-making may be represented in the corresponding DMN decision models. To this end, we identify a set of patterns that capture possible representations of data in BPMN processes and that can be used to guide the derivation of decision models related to existing process models. Throughout the paper we refer to real-world healthcare processes to show the applicability of the proposed approach. (C) 2019 Elsevier Ltd. All rights reserved.
Başaran, Nurşen ; Duydu, Yalçın ; Üstündağ, Aylin ; Taner, Gökçe ; Aydin Dilsiz, Sevtap ; Anlar, Hatice Gül ; Yalçin, Can Özgür ; Bacanli, Merve ; Golka, Klaus ; Schwerdtle, Tanja ; Bolt, Hermann M.
Boron (B) compounds are essential for plants and animals and beneficial for humans in nutritional amounts. I animals and humans increasing evidence have shown beneficial effects on B compounds on nutrition and on antioxidant status. The genotoxic effects of environmental B exposure in women living in boron-rich and boronpoor areas was examined in this study. For this purpose, the DNA damage in the lymphocytes and buccal cells of females were assessed by Comet and micronucleus (MN) assays respectively. No significant difference was observed in the DNA damage of the lymphocytes of B exposed groups of female volunteers in Comet assay. Even buccal micronucleus (MN) frequency observed in the high exposure group was significantly lower than the low exposure group (p < 0.05). The results of this study came to the same conclusions of the previous studies that boron does not induce DNA damage even under extreme exposure conditions.
By adapting the Cheeger-Simons approach to differential cohomology, we establish a notion of differential cohomology with compact support. We show that it is functorial with respect to open embeddings and that it fits into a natural diagram of exact sequences which compare it to compactly supported singular cohomology and differential forms with compact support, in full analogy to ordinary differential cohomology. We prove an excision theorem for differential cohomology using a suitable relative version. Furthermore, we use our model to give an independent proof of Pontryagin duality for differential cohomology recovering a result of [Harvey, Lawson, Zweck - Amer. J. Math. 125 (2003), 791]: On any oriented manifold, ordinary differential cohomology is isomorphic to the smooth Pontryagin dual of compactly supported differential cohomology. For manifolds of finite-type, a similar result is obtained interchanging ordinary with compactly supported differential cohomology.
Becker, George D. ; Pettini, Max ; Rafelski, Marc ; Boera, Elisa ; Christensen, Lise ; Cupani, Guido ; Ellison, Sara L. ; Farina, Emanuele Paolo ; Fumagalli, Michele ; Lopez, Sebastian ; Neeleman, Marcel ; Ryan-Weber, Emma ; Worseck, Gabor
We present a survey for metal absorption systems traced by neutral oxygen over 3.2 < z < 6.5. Our survey uses Keck/ESI and VLT/X-Shooter spectra of 199 QSOs with redshifts up to 6.6. In total, we detect 74 OI absorbers, of which 57 are separated from the background QSO by more than 5000 km s(-1). We use a maximum likelihood approach to fit the distribution of OI lambda 1302 equivalent widths in bins of redshift and from this determine the evolution in number density of absorbers with W-1302 > 0.05 angstrom, of which there are 49 nonproximate systems in our sample. We find that the number density does not monotonically increase with decreasing redshift, as would naively be expected from the buildup of metal-enriched circumgalactic gas with time. The number density over 4.9 < z < 5.7 is a factor of 1.7-4.1 lower (68% confidence) than that over 5.7 < z < 6.5, with a lower value at z < 5.7 favored with 99% confidence. This decrease suggests that the fraction of metals in a low-ionization phase is larger at z similar to 6 than at lower redshifts. Absorption from highly ionized metals traced by CIV is also weaker in higher-redshift OI systems, supporting this picture. The evolution of OI absorbers implies that metal-enriched circumgalactic gas at z similar to 6 is undergoing an ionization transition driven by a strengthening ultraviolet background. This in turn suggests that the reionization of the diffuse intergalactic medium may still be ongoing at or only recently ended by this epoch.
Beckmann, Nadine ; Becker, Katrin Anne ; Kadow, Stephanie ; Schumacher, Fabian ; Kramer, Melanie ; Kuehn, Claudine ; Schulz-Schaeffer, Walter J. ; Edwards, Michael J. ; Kleuser, Burkhard ; Gulbins, Erich ; Carpinteiro, Alexander
Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan. We have recently reported a novel acid ceramidase deficiency model that mirrors the human disease closely. Acid sphingomyelinase is the enzyme that generates ceramide upstream of acid ceramidase in the lysosomes. Using our acid ceramidase deficiency model, we tested if acid sphingomyelinase could be a potential novel therapeutic target for the treatment of Farber disease. A number of functional acid sphingomyelinase inhibitors are clinically available and have been used for decades to treat major depression. Using these as a therapeutic for Farber disease, thus, has the potential to improve central nervous symptoms of the disease as well, something all other treatment options for Farber disease can’t achieve so far. As a proof-of-concept study, we first cross-bred acid ceramidase deficient mice with acid sphingomyelinase deficient mice in order to prevent ceramide accumulation. Double-deficient mice had reduced ceramide accumulation, fewer disease manifestations, and prolonged survival. We next targeted acid sphingomyelinase pharmacologically, to test if these findings would translate to a setting with clinical applicability. Surprisingly, the treatment of acid ceramidase deficient mice with the acid sphingomyelinase inhibitor amitriptyline was toxic to acid ceramidase deficient mice and killed them within a few days of treatment. In conclusion, our study provides the first proof-of-concept that acid sphingomyelinase could be a potential new therapeutic target for Farber disease to reduce disease manifestations and prolong survival. However, we also identified previously unknown toxicity of the functional acid sphingomyelinase inhibitor amitriptyline in the context of Farber disease, strongly cautioning against the use of this substance class for Farber disease patients.
We study the spectral location of a strongly pattern equivariant Hamiltonians arising through configurations on a colored lattice. Roughly speaking, two configurations are "close to each other" if, up to a translation, they "almost coincide" on a large fixed ball. The larger this ball, the more similar they are, and this induces a metric on the space of the corresponding dynamical systems. Our main result states that the map which sends a given configuration into the spectrum of its associated Hamiltonian, is Holder (even Lipschitz) continuous in the usual Hausdorff metric. Specifically, the spectral distance of two Hamiltonians is estimated by the distance of the corresponding dynamical systems.
High Harmonic Generation (HHG) is a nonlinear optical process that provides a tunable source for high-energy photons and ultrashort laser pulses. Recent experiments demonstrated that HHG spectroscopy may also be used as an analytical tool to discriminate between randomly oriented configurational isomers of polyatomic organic molecules, namely, between the cis- and trans-forms of 1,2-dichloroethene (DCE) [M. C. H. Wong et al., Phys. Rev. A 84, 051403 (2011)]. Here, we suggest as an economic and at the same time a reasonably accurate method to compute HHG spectra for polyatomic species, Time-Dependent Configuration Interaction Singles (TD-CIS) theory in combination with extended atomic orbital bases and different models to account for ionization losses. The HHG spectra are computed for aligned and unaligned cis- and trans-DCE. For the unaligned case, a coherent averaging over possible rotational orientations is introduced. Furthermore, using TD-CIS, possible differences between the HHG spectra of cis- and trans-DCE are studied. For aligned molecules, spectral differences between cis and trans emerge, which can be related to their different point group symmetries. For unaligned, randomly oriented molecules, we also find distinct HHG spectra in partial agreement with experiment. In addition to HHG response in the frequency space, we compute time-frequency HHG spectra to gain insight into which harmonics are emitted at which time. Further differences between the two isomers emerge, suggesting time-frequency HHG as another tool to discriminate configurational isomers.
Cystine was used as a platform chemical to prepare cyclic and acyclic monomers for entropy-driven ringopening polymerization (ED-ROMP) via olefin or disulfide metathesis and for step-growth polymerization. The olefin ED-ROMP of an olefin/disulfide containing 16-atom macrocycle using the 3rd generation Grubbs catalyst was examined in greater detail. Kinetic studies revealed that the catalyst turned inactive during the polymerization, which limited the achievable (apparent) polymer molar mass to similar to 70 kg mol(-1). Such limitation could be overcome with the disulfide ED-ROMP of the same macrocycle to yield polymers with molar masses of up to 180 kg mol(-1). The step-growth polymerizations of acyclic diene and dithiol monomers via olefin metathesis or oxidation were far less effective and yielded just low molar mass polymers or oligomers; photopolymerization of a thiol-ene monomer produced a polyester with a molar mass of 35 kg mol(-1).
Ben Dor, Yoav ; Neugebauer, Ina ; Enzel, Yehouda ; Schwab, Markus Julius ; Tjallingii, Rik ; Erel, Yigal ; Brauer, Achim
The sedimentary record of the Dead Sea provides an exceptional high-resolution archive of past climate changes in the drought-sensitive eastern Mediterranean-Levant, a key region for the development of humankind at the boundary of global climate belts. Moreover, it is the only deep hypersaline lake known to have deposited long sequences of finely laminated, annually deposited sediments (i.e. varves) of varied compositions, including aragonite, gypsum, halite and clastic sediments. Vast efforts have been made over the years to decipher the environmental information stored in these evaporitic-clastic sequences spanning from the Pleistocene Lake Amora to the Holocene Dead Sea. A general characterisation of sediment facies has been derived from exposed sediment sections, as well as from shallow- and deep-water sediment cores. During high lake stands and episodes of positive water budget, mostly during glacial times, alternating aragonite and detritus laminae (‘aad’ facies) were accumulated, whereas during low lake stands and droughts, prevailing during interglacials, laminated detritus (‘ld’ facies) and laminated halite (‘lh’ facies) dominate the sequence. In this paper, we (i) review the three types of laminated sediments of the Dead Sea sedimentary record (‘aad’, ‘ld’ and ‘lh’ facies), (ii) discuss their modes of formation, deposition and accumulation, and their interpretation as varves, and (iii) illustrate how Dead Sea varves are utilized for palaeoclimate reconstructions and for establishing floating chronologies.
Ben Othman, Aymen ; Chaouachi, Anis ; Chaouachi, Mehdi ; Makhlouf, Issam ; Farthing, Jonathan P. ; Granacher, Urs ; Behm, David G.
Cross-education has been extensively investigated with adults. Adult studies report asymmetrical cross-education adaptations predominately after dominant limb training. The objective of the study was to examine unilateral leg press (LP) training of the dominant or nondominant leg on contralateral and ipsilateral strength and balance measures. Forty-two youth (10-13 years) were placed (random allocation) into a dominant (n = 15) or nondominant (n = 14) leg press training group or nontraining control (n = 13). Experimental groups trained 3 times per week for 8 weeks and were tested pre-/post-training for ipsilateral and contralateral 1-repetition maximum (RM) horizontal LP, maximum voluntary isometric contraction (MVIC) of knee extensors (KE) and flexors (KF), countermovement jump (CMJ), triple hop test (THT), MVIC strength of elbow flexors (EF) and handgrip, as well as the stork and Y balance tests. Both dominant and nondominant LP training significantly (p < 0.05) increased both ipsilateral and contralateral lower body strength (LP 1RM (dominant: 59.6%-81.8%; nondominant: 59.5%-96.3%), KE MVIC (dominant: 12.4%-18.3%; nondominant: 8.6%-18.6%), KF MVIC (dominant: 7.9%-22.3%; nondominant: nonsignificant-3.8%), and power (CMJ: dominant: 11.1%-18.1%; nondominant: 7.7%-16.6%)). The exception was that nondominant LP training demonstrated a nonsignificant change with the contralateral KF MVIC. Other significant improvements were with nondominant LP training on ipsilateral EF 1RM (6.2%) and THT (9.6%). There were no significant changes with EF and handgrip MVIC. The contralateral leg stork balance test was impaired following dominant LP training. KF MVIC exhibited the only significant relative post-training to pretraining (post-test/pre-test) ratio differences between dominant versus nondominant LP cross-education training effects. In conclusion, children exhibit symmetrical cross-education or global training adaptations with unilateral training of dominant or nondominant upper leg.