Refine
Year of publication
Document Type
- Article (237)
- Doctoral Thesis (140)
- Conference Proceeding (122)
- Postprint (69)
- Working Paper (36)
- Monograph/Edited Volume (16)
- Preprint (6)
- Review (6)
- Master's Thesis (5)
- Habilitation Thesis (2)
Language
- English (641) (remove)
Keywords
- climate change (8)
- USA (7)
- United States (7)
- moderne jüdische Geschichte (6)
- Arktis (5)
- COVID-19 (5)
- Fernerkundung (5)
- football (5)
- modern Jewish history (5)
- 20. Jahrhundert (4)
Institute
- Extern (641) (remove)
Contents: 1. Introduction 2. Migration and Assimilation – Theoretical Approaches 2.1 Meaning and Definition of the Terms Migration and Migrant 2.2 Milton M. Gordon – Sub Processes of Assimilation 2.3 Hartmut Esser - Acculturation, Integration, and Assimilation 2.4 The Concept of Integration and Assimilation 2.5 Straight–line Assimilation and its Implications 2.6 Segmented Assimilation and its Implications 3. Social Inequality and Welfare – Theoretical Approaches 3.1 Dimensions of Inequality 3.2 Welfare Regimes and Social Inequality 3.3 Migration, Assimilation and Inequality 4. Research Design 4.1 Research Question and General Proceeding 4.2 Sample and Data Base 4.3 Operationalisation and Indicators 5. Migration, Welfare and Inequality in Three European Countries 6. Empirical Results 6.1 Performance of Migrants Compared With Natives 6.2 Different Trajectories of Assimilation 6.3 Trajectories of Segmented Assimilation and their Determinants 6.4 Policies, Attitudes and Assimilation – An Aggregate Analysis 6.5 Summary – What Determines the Performance of Migrants? 7. Discussion of Empirical Results in Terms of Theoretical Approaches 7.1 The Situation of Migrants in Three European Countries 7.2 Assessment of the Trajectories of Assimilation 8. Conclusion – Future Prospects of Migration in Europe
This dissertation aimed to determine differential expressed miRNAs in the context of chronic pain in polyneuropathy. For this purpose, patients with chronic painful polyneuropathy were compared with age matched healthy patients. Taken together, all miRNA pre library preparation quality controls were successful and none of the samples was identified as an outlier or excluded for library preparation. Pre sequencing quality control showed that library preparation worked for all samples as well as that all samples were free of adapter dimers after BluePippin size selection and reached the minimum molarity for further processing. Thus, all samples were subjected to sequencing. The sequencing control parameters were in their optimal range and resulted in valid sequencing results with strong sample to sample correlation for all samples. The resulting FASTQ file of each miRNA library was analyzed and used to perform a differential expression analysis. The differentially expressed and filtered miRNAs were subjected to miRDB to perform a target prediction. Three of those four miRNAs were downregulated: hsa-miR-3135b, hsa-miR-584-5p and hsa-miR-12136, while one was upregulated: hsa-miR-550a-3p. miRNA target prediction showed that chronic pain in polyneuropathy might be the result of a combination of miRNA mediated high blood flow/pressure and neural activity dysregulations/disbalances. Thus, leading to the promising conclusion that these four miRNAs could serve as potential biomarkers for the diagnosis of chronic pain in polyneuropathy.
Since TRPV1 seems to be one of the major contributors of nociception and is associated with neuropathic pain, the influence of PKA phosphorylated ARMS on the sensitivity of TRPV1 as well as the part of AKAP79 during PKA phosphorylation of ARMS was characterized. Therefore, possible PKA-sites in the sequence of ARMS were identified. This revealed five canonical PKA-sites: S882, T903, S1251/52, S1439/40 and S1526/27. The single PKA-site mutants of ARMS revealed that PKA-mediated ARMS phosphorylation seems not to influence the interaction rate of TRPV1/ARMS. While phosphorylation of ARMST903 does not increase the interaction rate with TRPV1, ARMSS1526/27 is probably not phosphorylated and leads to an increased interaction rate. The calcium flux measurements indicated that the higher the interaction rate of TRPV1/ARMS, the lower the EC50 for capsaicin of TRPV1, independent of the PKA phosphorylation status of ARMS. In addition, the western blot analysis confirmed the previously observed TRPV1/ARMS interaction. More importantly, AKAP79 seems to be involved in the TRPV1/ARMS/PKA signaling complex. To overcome the problem of ARMS-mediated TRPV1 sensitization by interaction, ARMS was silenced by shRNA. ARMS silencing resulted in a restored TRPV1 desensitization without affecting the TRPV1 expression and therefore could be used as new topical therapeutic analgesic alternative to stop ARMS mediated TRPV1 sensitization.
Previous hydrometric studies demonstrated the prevalence of overland flow as a hydrological pathway in the tropical rain forest catchment of South Creek, northeast Queensland. The purpose of this study was to consider this information in a mixing analysis with the aim of identifying sources of, and of estimating their contribution to, storm flow during two events in February 1993. K and acid-neutralizing capacity (ANC) were used as tracers because they provided the best separation of the potential sources, saturation overland flow, soil water from depths of 0.3, 0.6, and 1.2 m, and hillslope groundwater in a two-dimensional mixing plot. It was necessary to distinguish between saturation overland flow, generated at the soil surface and following unchanneled pathways, and overland flow in incised pathways. This latter type of overland flow was a mixture of saturation overland flow (event water) with high concentrations of K and a low ANC, soil water (preevent water) with low concentrations of K and a low ANC, and groundwater (preevent water) with low concentrations of K and a high ANC. The same sources explained the streamwater chemistry during the two events with strongly differing rainfall and antecedent moisture conditions. The contribution of saturation overland flow dominated the storm flow during the first, high-intensity, 178-mm event, while the contribution of soil water reached 50% during peak flow of the second, low-intensity, 44-mm event 5 days later. This latter result is remarkably similar to soil water contributions to storm flow in mountainous forested catchments of the southeastern United States. In terms of event and preevent water the storm flow hydrograph of the high-intensity event is dominated by event water and that of the low-intensity event by preevent water. This study highlights the problems of applying mixing analyses to overland flow-dominated catchments and soil environments with a poorly developed vertical chemical zonation and emphasizes the need for independent hydrometric information for a complete characterization of watershed hydrology and chemistry.
Background
The metabolic syndrome (MetS) is a risk cluster for a number of secondary diseases. The implementation of prevention programs requires early detection of individuals at risk. However, access to health care providers is limited in structurally weak regions. Brandenburg, a rural federal state in Germany, has an especially high MetS prevalence and disease burden. This study aims to validate and test the feasibility of a setup for mobile diagnostics of MetS and its secondary diseases, to evaluate the MetS prevalence and its association with moderating factors in Brandenburg and to identify new ways of early prevention, while establishing a “Mobile Brandenburg Cohort” to reveal new causes and risk factors for MetS.
Methods
In a pilot study, setups for mobile diagnostics of MetS and secondary diseases will be developed and validated. A van will be equipped as an examination room using point-of-care blood analyzers and by mobilizing standard methods. In study part A, these mobile diagnostic units will be placed at different locations in Brandenburg to locally recruit 5000 participants aged 40-70 years. They will be examined for MetS and advice on nutrition and physical activity will be provided. Questionnaires will be used to evaluate sociodemographics, stress perception, and physical activity. In study part B, participants with MetS, but without known secondary diseases, will receive a detailed mobile medical examination, including MetS diagnostics, medical history, clinical examinations, and instrumental diagnostics for internal, cardiovascular, musculoskeletal, and cognitive disorders. Participants will receive advice on nutrition and an exercise program will be demonstrated on site. People unable to participate in these mobile examinations will be interviewed by telephone. If necessary, participants will be referred to general practitioners for further diagnosis.
Discussion
The mobile diagnostics approach enables early detection of individuals at risk, and their targeted referral to local health care providers. Evaluation of the MetS prevalence, its relation to risk-increasing factors, and the “Mobile Brandenburg Cohort” create a unique database for further longitudinal studies on the implementation of home-based prevention programs to reduce mortality, especially in rural regions.
Trial registration
German Clinical Trials Register, DRKS00022764; registered 07 October 2020—retrospectively registered.
This article explores the multi-directional geographic trajectories and ties of Jews who came to the United States in the 19th century, working to complicate simplistic understandings of “German” Jewish immigration. It focuses on the case study of Henry Cohn, an ordinary Russian-born Jew whose journeys took him to Prussia, New York, Savannah, and California. Once in the United States he returned to Europe twice, the second time permanently, although a grandson ended up in California, where he worked to ensure the preservation of Cohn’s records. This story highlights how Jews navigated and transgressed national boundaries in the 19th century and the limitations of the historical narratives that have been constructed from their experiences.
The requirements of modern e-learning techniques change. Aspects such as community interaction, flexibility, pervasive learning and increasing mobility in communication habits become more important. To meet these challenges e-learning platforms must provide support on mobile learning. Most approaches try to adopt centralised and static e-learning mechanisms to mobile devices. However, often technically it is not possible for all kinds of devices to be connected to a central server. Therefore we introduce an application of a mobile e-learning network which operates totally decentralised with the help of an underlying ad hoc network architecture. Furthermore the concept of ad hoc messaging network (AMNET) is used as basis system architecture for our approach to implement a platform for pervasive mobile e-learning.
One type of internal diachronic change that has been extensively studied for spoken languages is grammaticalization whereby lexical elements develop into free or bound grammatical elements. Based on a wealth of spoken languages, a large amount of prototypical grammaticalization pathways has been identified. Moreover, it has been shown that desemanticization, decategorialization, and phonetic erosion are typical characteristics of grammaticalization processes. Not surprisingly, grammaticalization is also responsible for diachronic change in sign languages. Drawing data from a fair number of sign languages, we show that grammaticalization in visual-gestural languages – as far as the development from lexical to grammatical element is concerned – follows the same developmental pathways as in spoken languages. That is, the proposed pathways are modalityindependent. Besides these intriguing parallels, however, sign languages have the possibility of developing grammatical markers from manual and non-manual co-speech gestures. We will discuss various instances of grammaticalized gestures and we will also briefly address the issue of the modality-specificity of this phenomenon.
We analyze anaphoric phenomena in the context of building an input understanding component for a conversational system for tutoring mathematics. In this paper, we report the results of data analysis of two sets of corpora of dialogs on mathematical theorem proving. We exemplify anaphoric phenomena, identify factors relevant to anaphora resolution in our domain and extensions to the input interpretation component to support it.
We apply the 3-dimensional radiative transport codeWind3D to 3D hydrodynamic models of Corotating Interaction Regions to fit the detailed variability of Discrete Absorption Components observed in Si iv UV resonance lines of HD 64760 (B0.5 Ib). We discuss important effects of the hydrodynamic input parameters on these large-scale equatorial wind structures that determine the detailed morphology of the DACs computed with 3D transfer. The best fit model reveals that the CIR in HD 64760 is produced by a source at the base of the wind that lags behind the stellar surface rotation. The non-corotating coherent wind structure is an extended density wave produced by a local increase of only 0.6% in the smooth symmetric wind mass-loss rate.
Extreme flooding displaces an average of 12 million people every year. Marginalized populations in low-income countries are in particular at high risk, but also industrialized countries are susceptible to displacement and its inherent societal impacts. The risk of being displaced results from a complex interaction of flood hazard, population exposed in the floodplains, and socio-economic vulnerability. Ongoing global warming changes the intensity, frequency, and duration of flood hazards, undermining existing protection measures. Meanwhile, settlements in attractive yet hazardous flood-prone areas have led to a higher degree of population exposure. Finally, the vulnerability to displacement is altered by demographic and social change, shifting economic power, urbanization, and technological development. These risk components have been investigated intensively in the context of loss of life and economic damage, however, only little is known about the risk of displacement under global change.
This thesis aims to improve our understanding of flood-induced displacement risk under global climate change and socio-economic change. This objective is tackled by addressing the following three research questions. First, by focusing on the choice of input data, how well can a global flood modeling chain reproduce flood hazards of historic events that lead to displacement? Second, what are the socio-economic characteristics that shape the vulnerability to displacement? Finally, to what degree has climate change potentially contributed to recent flood-induced displacement events?
To answer the first question, a global flood modeling chain is evaluated by comparing simulated flood extent with satellite-derived inundation information for eight major flood events. A focus is set on the sensitivity to different combinations of the underlying climate reanalysis datasets and global hydrological models which serve as an input for the global hydraulic model. An evaluation scheme of performance scores shows that simulated flood extent is mostly overestimated without the consideration of flood protection and only for a few events dependent on the choice of global hydrological models. Results are more sensitive to the underlying climate forcing, with two datasets differing substantially from a third one. In contrast, the incorporation of flood protection standards results in an underestimation of flood extent, pointing to potential deficiencies in the protection level estimates or the flood frequency distribution within the modeling chain.
Following the analysis of a physical flood hazard model, the socio-economic drivers of vulnerability to displacement are investigated in the next step. For this purpose, a satellite- based, global collection of flood footprints is linked with two disaster inventories to match societal impacts with the corresponding flood hazard. For each event the number of affected population, assets, and critical infrastructure, as well as socio-economic indicators are computed. The resulting datasets are made publicly available and contain 335 displacement events and 695 mortality/damage events. Based on this new data product, event-specific displacement vulnerabilities are determined and multiple (national) dependencies with the socio-economic predictors are derived. The results suggest that economic prosperity only partially shapes vulnerability to displacement; urbanization, infant mortality rate, the share of elderly, population density and critical infrastructure exhibit a stronger functional relationship, suggesting that higher levels of development are generally associated with lower vulnerability.
Besides examining the contextual drivers of vulnerability, the role of climate change in the context of human displacement is also being explored. An impact attribution approach is applied on the example of Cyclone Idai and associated extreme coastal flooding in Mozambique. A combination of coastal flood modeling and satellite imagery is used to construct factual and counterfactual flood events. This storyline-type attribution method allows investigating the isolated or combined effects of sea level rise and the intensification of cyclone wind speeds on coastal flooding. The results suggest that displacement risk has increased by 3.1 to 3.5% due to the total effects of climate change on coastal flooding, with the effects of increasing wind speed being the dominant factor.
In conclusion, this thesis highlights the potentials and challenges of modeling flood- induced displacement risk. While this work explores the sensitivity of global flood modeling to the choice of input data, new questions arise on how to effectively improve the reproduction of flood return periods and the representation of protection levels. It is also demonstrated that disentangling displacement vulnerabilities is feasible, with the results providing useful information for risk assessments, effective humanitarian aid, and disaster relief. The impact attribution study is a first step in assessing the effects of global warming on displacement risk, leading to new research challenges, e.g., coupling fluvial and coastal flood models or the attribution of other hazard types and displacement events. This thesis is one of the first to address flood-induced displacement risk from a global perspective. The findings motivate for further development of the global flood modeling chain to improve our understanding of displacement vulnerability and the effects of global warming.